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What is Embryonic hemoglobin is: and explain in detail?
Normal mammalian hemoglobins contain two pairs of unlike polypeptide chains: one chain of each pair is or -like and the other is non- (, , or ). The -chains of all human hemoglobins encountered after early embryogenesis are the same. The non- chains include the -chain of normal adult hemoglobin (Hb A ), the -chain of fetal hemoglobin (Hb F ), and the -chain of Hb A2 (Hb A2 ), the minor component, which accounts for 2.5 percent of the hemoglobin of normal adults.The -chain of fetal hemoglobin (Hb F) differs from the -chain by 39 residues. Ref: Natarajan K., Townes T.M., Kutlar A. (2010). Chapter 48. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities. In J.T. Prchal, K. Kaushansky, M.A. Lichtman, T.J. Kipps, U. Seligsohn (Eds), Williams Hematology, 8e.