You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 50-year-old male with a positive family history of prostate cancer has come to you for a screening test. The most sensitive screening test to pickup prostate cancer is and explain in detail?
At the present time the data suggest that if screening is done, the combination of DRE & Serum PSA is best." The diagnosis of Ca Prostate is established by TRUS-guided transrectal biopsy. Ref : Smith's Urology 17/e p363