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What is Hemophia A due to deficiency of - and explain in detail?
Ans. is 'a' i.e., Factor VIII HemophilaA;-o Hemophilia A is due to deficiency of factor VIILo Hemophilia A is inherited as an X-linkedrecessive trait.o Factor VIII is an intrinsic pathway component required for activation of factor X.Clinical manifestations are due to defect in coagulation system : -Large post traumatic ecchymoses or hematoma.Prolonged bleeding after a laceration or any form of surgical procedure.Bleeding into weight bearing joints.o Petechiae are characteristically absent (in contrast to platelet dysfunction where bleeding occur from small vessels of skin and mucous membrane, e,g.t petechiae).Laboratory findings :-# | PTT# Normal BT# Normal PT# Normal platelet countsRemembero Hemophilia B (christmas disease> is due to deficiency of factor IX.o Hemophilia B has clinical features and laboratory findings similar to hemophilia A.