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What is Features of multiple myeloma are and explain in detail?
Multiple myeloma is a malignant proliferation of plasma cells. Normal plasma cells are derived from B cells & prodece immunoglobulins which contain heavy & light chains. Normal immunoglobulins are polyclonal,which means that a variety of heavy chains are produced . In myelona,plasma cells produce immunoglobulin of a single hwavy & light chain , a monoclonal protein commonly referred to as a paraprotein.Reference :Davidson's principles &practice of medicine 22nd edition pg no 1046.