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What is In patients with Chronic Myeloid Leukemia and explain in detail?
Ans. (b) The fusion gene bcr-abl forms a protein with tyrosine kinase activity(Ref: Robbins 9th/pg 616-618)a. FALSE, as ABL gene is on chr9q while BCR is on chr22qb. The fusion gene bcr-abl forms a protein with tyrosine kinase activity: TRUEc. FALSE; Massive splenomegaly is a feature of CMLd. FALSE; as response to Imatinib is good in patients with Philadelphia chromosome +ve