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What is Mechanism of action of levosimenden is ? and explain in detail?
Ans. is b i.e., Potassium channel opener Levosimendon A new ionodilator is Levosimendon It has inodilator effect by: i) Inotropic effect : Levosimendon is calcium sensitiser, i.e. it increases the sensitivity of the hea to calcium that results in increased cardiac contractility without a rise in intracellular calcium. ii) Vasodilatory effect : by opening ATP-sensitive potassium channels in vascular smooth muscles it causes smooth muscle relaxation.