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What is The most appropriate drug used for chelation therapy in beta thalassemia major is - and explain in detail?
Ans. is 'b' i.e., Oral deferiprone Desferrioxamine is poorly absorbed from GIT and hence not recommended for oral administration, although it continues to be the chelating agent of choice for parentral administration. o Deferiprone is a recently introduced orally active iron chelating agent meant to be used as an alternative to injected desferrioxamine. o Oral Deferiprone is prefered over oral desferrioxamine. Remember o For acute iron poisoning desferioxamine is the DOC. o For chronic iron overload, e.g. thalassemia, oral deferipone is the DOC.