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What is A 44-year old male having a long history of cigarette smoking presented with gangrene of left foot. An amputation of the left foot was done. Representative sections from the specimen revealed presence of aerial thrombus with neutrophilic infiltrate in the aerial wall. The inflammation also extended into the neighboring veins and nerves. The most probable diagnosis is: and explain in detail?
BUERGER'S DISEASE (Thromboangiitis obliterans) - Segmental inflammatory disease, affecting small and medium sized aeries in upper and lower extremities - Inflammatory process involves neighboring veins and nerves - Typically seen in young, male smokers (not females and non-smokers) - Thrombus contain micro abscess . - Characterized by triad of intermittent claudication, Raynaud's phenomenon , migrated superficial vein thrombophlebitis