You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following types of hepatitis is associated with an immune-mediated vasculitis characterized by p-ANCA antibodies? and explain in detail?
Hepatitis B is associated with polyaeritis nodosa (PAN), a necrotizing vasculitis of small- and medium-sized muscular aeries involving all organ systems. A significant percentage of patients with PAN have hepatitis B antigenemia. They also have circulating immune complexes containing hepatitis B antigen. Hepatitis B antigen, IgM, and complement can be demonstrated in blood vessel walls. P-ANCA (perinuclear-anti nuclear cytoplasmic antibody) is a marker for polyaeritis nodosa. Hepatitis A is not associated with a vasculitis. Hepatitis C accounts for 50-70% of chronic hepatitis. Chronic hepatitis C can be associated with immune-complex mediated extrahepatic complications, but is less common than hepatitis B. Hepatitis C does have a significant association with essential mixed cryoglobulinemia, which presents with glomerulonephritis, ahralgias, hepatosplenomegaly, and lymphadenopathy, in addition to a vasculitis. However, there is no association with p-ANCA. Hepatitis D requires that the patient be co-infected with hepatitis B. As such, it does not independently cause disease, but it can produce a worsening of the liver disease.