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What is ADAMTS-13 is a metalloproteinase. It is produced by the: and explain in detail?
Ans. C. Stellate cells in the liverADAMTS-13 is a metalloproteinase which is produced by the stellate cells of the liver. It cleaves von Willebrand factor. Therefore, when ADAMTS-13 deficiency occurs, large multimer of VWF attach to platelets and cause microcirculatory failure.