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What is Synucleinopathy and explain in detail?
Synucleinopathies (also called α-Synucleinopathies) are neurodegenerative diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells.  There are three main types of synucleinopathy: Parkinsons disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Other rare disorders, such as various neuroaxonal dystrophies, also have α-synuclein pathologies. Additionally, autopsy studies have shown that around 6% of sporadic Alzheimers Disease exhibit α-synuclein positive Lewy pathology, and are sub-classed as Alzheimers Disease with Amygdalar Restricted Lewy Bodies (AD/ALB).

Presentation
The synucleinopathies have shared features of parkinsonism, impaired cognition, sleep disorders, and visual hallucinations.Synucleinopathies can sometimes overlap with tauopathies, possibly because of interaction between the synuclein and tau proteins.REM sleep behavior disorder (RBD) is a parasomnia in which individuals with RBD lose the paralysis of muscles (atonia) that is normal during rapid eye movement (REM) sleep, and act out their dreams or have other abnormal movements or vocalizations.   Abnormal sleep behaviors may appear decades before any other symptoms, often as an early sign of a synucleinopathy