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What is Netupitant/palonosetron and explain in detail?
Netupitant/palonosetron, sold under the brand name Akynzeo, is a fixed-dose combination medication used for the prevention of acute and delayed chemotherapy-induced nausea and vomiting. It is marketed and distributed by Helsinn Therapeutics. Netupitant is an NK1 receptor antagonist and palonosetron is a 5-HT3 receptor antagonist.The capsules contain netupitant and palonosetron hydrochloride. The intravenous version is a combination of fosnetupitant chloride hydrochloride and palonosetron hydrochloride.

Contraindications
Netupitant/palonosetron may be contraindicated during pregnancy.

Adverse effects
The most common side effects include headache, weakness, fatigue, upset stomach, constipation, and skin redness