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What is Which of he following enzyme is involved in the catabolism of fructose to pyruvate in the liver? and explain in detail?
Fructose is a ketohexose presents in fruits, honey, and sucrose. Fructose is promptly metabolized by the liver. Fructose is phosphorylated by fructokinase, an enzyme present in the liver with a high affinity for fructose to Fructose-1-phosphate. Then Fructose-1-phosphate is then cleaved to Glyceraldehyde by aldolase-B. The Glyceraldehyde is phosphorylated to Glyceraldehyde-3-phosphate by triose kinase and ATP. Glyceraldehyde-3-phosphate + dihydroxyacetone gives 1,3 bisphosphoglycerate catalysed by Glyceraldehyde-3-phosphate Dehydrogenase. This 1,3 bisphosphoglycerate is finally metabolized into pyruvate. Ref: Vasudevan Biochemistry, 4th Edition, Pages 88, 119-120