You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is inappropriate indication for concomitant chemotherapy in case of head and neck cancer? and explain in detail?
(d) Metastatic advanced head and neck cancer(Ref. Cummings, 6th ed., 1620)Concomitant chemotherapy or Concurrent chemoradiotherapy/chemoradiation maximizes tumour control while maintaining function and quality of life by organ-conservation (e.g. ca larynx), because of which this treatment modality has overtaken surgery as the primary local treatment option for most head and neck cancers.It is also the primary mode of treatment for tumours which cannot be treated surgically because of lack of free margins, e.g. nasopharyngeal carcinoma, etc.In addition, for those patients whose head and neck cancers are managed with primary surgical resection, patients at high risk of loco regional recurrence (positive margins or extracapsular nodal extension) are often treated with concurrent chemoradiotherapy, for enhancement of loco regional control.In metastasis the treatment is palliative radiotherapy.