You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Alkaline diuresis is done for treatment of poisoning due to: and explain in detail?
* Phenobarbitone- is a derivative of barbituric acid (weakly acidic drug) and its excretion can be enhanced by making the urine alkaline. * Tubular reabsorption depends on the lipid solubility. If a drug is lipid soluble, more of it will be reabsorbed and less will be excreted. Opposite is true for lipid insoluble drugs. * As lipid solubility depends on ionization, the ionized drug will be excreted by the kidney. Thus, in acidic drug poisoning (salicylate, barbiturates etc.) urine should be alkalinized with sodium bicarbonate because weak acids are in ionized form in alkaline urine and thus are easily excreted. * Similarly, for basic drug poisoning (e.g. morphine, amphetamine etc.), urine should be acidified using ammonium chloride.