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What is Allergic bronchopulmonary aspergillosis is (ABPA) usually diagnosed by A/E: and explain in detail?
Ans: A (Peripheral blood eosinophilia >0.5x1010) Ref: Harrison, 16th, ed. p. 1257; 17th, ed, p. 1259Definitive major and minor criterias are defined for allergic bronchopulmonary aspergillosis. Ig A is not present in these criteria.Major diagnostic criteria1. Clinical history of asthma2. Pulmonary infiltrates (transient or fixed)3. Peripheral eosinophilia (> 1000/uL)4. Immediate skin reactivity to aspergillus antigen.5. Serum precipitates to A. fiimigatus6. Elevated serum IgE levels.7. Central / proximal bronchiectasisSecondary diagnostic criteria1. History of brownish plugs in sputum2. Culture of A. fumigatus from sputum3. Late skin reactivity to aspergillus antigen4. Elevated IgE (and IgG) class antibodies specific for A. fumigatus.