You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The following anti-HIV drug should not be combined with zidovudine because of mutual antagonism and explain in detail?
Stavudine (d4T) It is also a thymidine analogue which acts by utilizing the thymidine kinase for activation, AZT(zidovudine) antagonises the effect of stavudine and the two should not be used together. It should also not be combined with didanosine, because both cause peripheral neuropathy. side effects:- Frequent peripheral neuropathy, lipodystrophy, lactic acidosis, and rarely pancreatitis are noted. Ref:- kd tripathi; pg num:-807