You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is All are seen in Thalassemia major EXCEPT and explain in detail?
Ans.(a) Macrocytic anemiaRef: Harrison 19th ed. / 637* Thalassemia major is a hemolytic anemia where defective RBC s are produced resulting in transfusion dependency since the defective RBC s are destroyed by the spleen. These defective RBC in blood circulation are referred to as target cells on a peripheral smear.* The type of anemia seen is referred to as Microcytic Hypochromic anemia.* The Hematopoiesis that occurs in liver and spleen in these patients is referred to as extramedullary hematopoiesis and is responsible for spleno-hepatomegaly in these patients.* IOC for thalassemia is hemoglobin electrophoresis and definitive treatment is bone marrow transplantation.* For survival however Packed RBC are required on regular basis and thus these patients are called transfusion dependant.