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What is Myotonic dystrophy is inherited in chromosomes and explain in detail?
Ans. is 'c' i.e., 19 o Myotonic dystrophy is associated with a trinucleotide CTG repeat expansion on chromosome 9. o This expansion affects the mRNA for the dystrophila myotonia protein kinase (DMPK). Myotonic dystrophy' o The characteristic feature of myotonic dystrophy is myotonia, i.e., the sustained involuntary contraction of group of muscles. o Of all the dysdrophies, only myotonic dystrophy shows pathological changes in the intrafusal fibres of the muscle spindles. o Extra-muscular abnormalities are : - Cataract Frontal baldness Gonadal atrophy o DM Dementia Decreased IgG