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What is After a solid organ transplantation, which of the following is responsible for acute graft rejection.? and explain in detail?
Ans. (d) C4d(Ref: Robbins 9th/234)Acute antibody-mediated rejection is manifested mainly by damage to glomeruli and small blood vessels. Typically, the lesions consist of inflammation of glomeruli and peritubular capillaries, associated with deposition of the complement breakdown product C4d, which is produced during activation of the complement system by the antibody dependent classical pathway