You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following connective tissue disorder is associated with gastroesophageal reflux? and explain in detail?
Scleroderma is systemic disease accompanied by esophageal abnormalities in approximately 80% of patients. The esophageal lesion consists of atrophy of the smooth muscles, manifested by weakness in the lower two-third of the esophageal body and incompetence of the LES. Gastroesophageal reflux is due to incompetent LES combined with poor esophageal clearance which inturn leads to severe reflux esophagitis and stricture formation. Ref: Schwaz 9/e, Page 846; Harrison 17/e, Page 1850.