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What is A 40 years old male from Himachal Pradesh has presented with verrucous lesions in the skin with following microscopic findings from the tissue biopsy. What is the diagnosis? and explain in detail?
Ans. (a) ChromoblastomycosisRef: Ananthanarayan and Paniker T.B of microbiology - 10th ed- page 605* Chromoblastomycosis is a fungal infection caused by pigmented fungi (also called as dematiaceous fungi)* It most commonly affects the agricultural workers and woodcutters, and usually follows a trauma.* It produces verrucous, warty, cutaneous nodules. Hence also called as verrucous dermatitis.* Agents:# Fonsecae spp.,# Exophiala spp.,# Cladophialophora* Lab diagnosis: KOH mount or tissue biopsy and staining of the lesions shows - irregular, dark brown bodies with septae (yeast like bodies) - called as Sclerotic bodies (seen in image as brown coloured)* Treatment: Amphotericin B, Itraconazole