You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Familial amyloidotic polyneuropathy is due to amyloidosis of nerves caused by deposition of ? and explain in detail?
Ans. is 'c' i.e., Mutant transthyretinTransthyretin (ATTR) amyloid Transthyretin (TTR) is normal serum protein that binds and transpo thyroxine and retinol.o TTR can cause following types of amyloidosis : ?1. Mutant TTR : - Mutation in TTR can cause syndrome of familial amyloidotic polyneuropathy or familial amylodotic cardiotnyopathy.2. Wild (non-mutant) TTR : - There is no mutation of TTR and wild type TTR forms fibrils which results in senile systemic amyloidosis (senile cardiac amyloidosis).