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What is The following monoclonal antibody is directed against alpha 4 integrin? and explain in detail?
NatalizumabNatalizumab is a humanized IgG4 monoclonal antibody that binds to the a4-subunit of a4b1 and a4b7 integrins expressed on the surfaces of all leukocytes except neutrophils and inhibits the a4-mediated adhesion of leukocytes to their cognate receptor. It is indicated for patients with multiple sclerosis and Crohn's disease who have not tolerated or had inadequate responses to conventional treatments.Ref: Katzung 13th ed.pg 993.