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What is Focal or confluent periportal necrosis along with ballooning degeneration of hepatocytes with or without Mallory bodies and megamitochondriais suggestive of? and explain in detail?
Ans. (c) Alcoholic liver injury(Ref: Rosai and Ackerman's Surgical Pathology, Volume 1, chapter 13, Box 13.2)Megamitochondria appear as eosinophilic, PAS- diastase-negative, round, oval, or cigar-shaped inclusionsBetter visualized with chromotrope-aniline blue (CAB) stain & immunohistochemistry.They are not specific for alcohol-induced liver disease, but found more frequently in alcohol-related fibrosisOxyphilic granular hepatocytes or oncocytes are a common, though not pathognomonic, cellular component in acute and chronic alcoholic liver disease.On Electron microscopy, Oncocytes are characterized by a large number of mitochondria (mitochondriosis).