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What is The treatment of Hodgkin's disease of stomach is - and explain in detail?
• Primary gastric Hodgkin’s disease is extremely rare (<1% of all gastric lymphomas)
• Stomach is the MC site of primary extranodal lymphoma in adults
Etiology:
• Association of classic Hodgkin’s disease with EBV
• LMP1 (Latent Membrane Protein 1) an essential EBV protein, commonly expressed and associated with the pathogenesis of Hodgkin’s disease
Diagnosis:
• Endoscopy: Non-specific gastritis or peptic ulcers with mass lesions
• A full panel of immunohistochemical markers is essential to make an accurate diagnosis of gastric Hodgkin’s disease.
Treatment:
• Hodgkin’s disease of the stomach has been treated by surgery while post operative chemotherapy has been employed for systemic disease.
Prognosis:
• Prognosis is poor with 45–60% of patients dying within the first year of diagnosis