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What is Submicroscopic deletions of any size can be detected by: and explain in detail?
a. Multiplex ligation-Dependent probe amplification(Ref: Nelson's 20/e p 605, Ghai 8/e p 6045)Multiplex Ligation-Dependent Probe Amplification (MLPA): It is a technique which mixes DNA hybridization, ligation, & PCR amplification to detect deletions & duplications of any size, including anomalies that are too large to be detected by PCR and too small to be identified by FISH.