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What is Which among the following selective serotonin reuptake inhibitors is longest acting? and explain in detail?
Special points Fluoxetine: It is a prototype SSRI and is longest acting drug in this group. It is metabolized to nor-fluoxetine that retains the anti-depressant activity. Thus it has minimum risk of causing drug-discontinuation symptoms which is characterized by symptoms like paresthesias, body ache & bowel disturbances. Fluvoxamine is the shoest acting SSRI. Paroxetine, seraline and citalopram are other SSRIs. Escitalopram is most specific SSRI. Paroxetine is most teratogenic among SSRIs.