You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following serum value is not in or of a diagnosis of PCOS? and explain in detail?
The polycystic ovarian disease is a heterogeneous, multisystem endocrinopathy in women of reproductive age.Endocrinological changes are as follows:1. Oestrone/E2 level rises.2. LH level is raised over 10 IU/mL. FSH level remains normal, but FSH/LH ratio falls.3. SHBG level falls due to hyperandrogenism.4. Testosterone and epi-androstenedione levels rise.5. Fasting blood glucose/fasting insulin, 4.5 suggests insulin resistance.6. Triglyceride level >150 mg/dL-hyperlipidaemia HDL < 50 mg/dL. Testosterone > 2 ng/mL, free T > 2.2 pg/mL (Normal level 0.2-0.8 ng/mL). Normal androstenedione level is 1.3-1.5 ng/mL. DHEA > 700 ng/mL suggests an adrenal tumor.7. Prolactin is mildly raised in 15% cases.8. Fasting insulin is more than 10 mIU/L in PCOS in 50-70/cases.9. Thyroid function tests may be abnormal (hypothyroidism).10. 17-a-hydroxyprogesterone in the follicular phase > 300 ng/dL suggests adrenal hyperplasia due to 21-hydroxylase deficiency.11. Urinary coisol < 50 mg/24 h.Ref: Shaw&;s textbook of gynecology; 16th edition; Page no: 432