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What is Achalasia cardia due to: and explain in detail?
Ans. (b) Degeneration and absence of ganglion cells in auerbach plexusRef: Bailey and Love 26th edition, Page 1014* Achalasia cardia is due to loss of ganglion cells in myenteric plexus.* Histology shows loss of inhibitory neurons with a variable degree of chronic inflammation.Important point of difference from Hirschsprung disease:* Dilated segment of Achalasia shows such loss of ganglion cells, whereas dilated Colon in Hirschsprung disease shows normal ganglion cells in dilated part.