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What is Lower esophageal sphincter pressure is increased by all of the following substances, EXCEPT: and explain in detail?
The lower esophageal sphincter, a physiologic entity but not an anatomic structure, plays an impoant pa in preventing gastroesophageal reflux. Neural, hormonal, myogenic, and mechanical factors influence the tone of the sphincter. Gastrin, vasopressin, glucagon, adrenergic agonists, and cholinergic agents increase the pressure. Secretin has the opposite effect REF: GUYTON 12TH ED