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What is Venlo-occlusive disease in hepatic vein is characterized by and explain in detail?
Venooccluisve disease It is a group of disorders in which hepatic venous outflow obstruction is due to sub endothelial sclerosis of sub lobular hepatic veins and terminal venules within the liver Clinical features Hall mark of VOD: Hyperbilirubinemia, tender hepatomegaly and fluid retention Onset of VOD usually occurs within 3 weeks after bine marrow transplantation, with a peak 12 days post transplantation Major cause of death is bleeding esophageal varices Modified seattle criteria : Two or more of the following must be present prior to 20 days after stem cell transplantation for diagnosis of VOD. Bilirubin >2mg/dl Tender hepatomegaly Ascites and/or unexplained weight gain of >2% above reference range Ref: Blumga 5th edition Pgno : 1189-1198