You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is In apoptosis, permeabilization of the membrane occurs in and explain in detail?
Mitochondria contain several proteins that are capable of inducing apoptosis; these proteins include cytochrome c and other proteins that neutralize endogenous inhibitors ofapoptosis. When cells are deprived of growth factors and other survival signals, or are exposed to agents that damage DNA, or accumulate unacceptable amounts of misfolded proteins, a number of sensors are activated. These sensors are members of the Bcl-2 family called "BH3 proteins" (because they contain only the third of multiple conserved domains of the Bcl-2 family). They, in turn, activate two pro-apoptotic members of the family called Bax and Bak, which dimerize, inse into the mitochondrial membrane, and form channels through which cytochrome c and other mitochondrial proteins escape into the cytosol.( Robbins Basic Pathology, 9th edition, page 18 )