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What is Birbeck granules in the cytoplasm is seen in: and explain in detail?
(Langerhans cells): Ref: 701-702-R, 463-HM (467-Basicpathology tfh)* The presence of Birbeck granules in the cytoplasm is characteristic of Langerhans cell histiocytosis (Tennis- rachet appearance)* As Birbeck granules are not seen in all tumours cells by electron microscopy the detection of 5-100 and CDla expression by immuno histochemical techniques aids in the diagnosis