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What is All of the following are seen in MEN-1 syndrome except: and explain in detail?
Ans: A. Posterior pituitary tumors(Ref Bailey 27/e p856-858, 26/e p795-797; Sabiston 20/e p993, 1003,- Harrison 19/e p2335)MEN type I (MEN 1):Also referred "Wermer's syndrome".Characterized by triad of tumors involving parathyroids, pancreatic islets & anterior pituitary (not the posterior pituitary tumors).Additionally adrenal coical tumors, carcinoid tumors usually of foregut, meningiomnas, facial angiofibromas, collagenomas, and lipomas also occur.Affects all age groups (age range 5 to 81 years).Clinical & biochemical manifestations developing mainly in 5th decade.In absence of treatment, endocrine tumors are associated with an earlier moality.Cause of death - Malignant tumor (pancreatic neuroendocrine tumor (NET) or foregut carcinoid).