You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Increased alkaline phosphatase is seen in - and explain in detail?
Ans. is 'c' i.e., Paget's disease o Whenever the activity of osteoblasts increase, serum alkaline phosphatase is raised. Therefore, serum alkaline phosphatase acts as an index of osteoblastic activity.o The conditions in which osteoblastic activity is increased and hence the alkaline phosphatase in increased are : -i) Rickets/osteomalaciav) Paget's disease (osteitis deformans)ii) Primary hyperparathyroidismvi) Osteoblastic secondariesiii) Renal osteodystrophy (secondary hyperparathyroidism) iv) Chronic renal failure and secondary hyperparathyroidism