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What is Dapsone is used for treatment of bacterial and fungal infections as well as for immunomodulatory actions. What is mechanism of dapsone for these indication? and explain in detail?
Sulfonamides (including Dapsone and PAS) : Competitively inhibit folic acid synthase enzyme as these are PABA analogues. Trimethoprim, Pyrimethamine : Inhibit Dihydro folate reductase enzyme (DHFRase). Inhibition of ergosterol in cell membrane (in fungus and leishmania): Amphotericin B.