You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The conjugation of bilirubin to glucuronic acid in the liver; and explain in detail?
Ans. is 'b' i.e. converts a hydrophobic compound to a hydrophilic one.Ref: Harrison 16th/e p 239 (15th/e p 255)Bilirubin is produced in the reticuloendothelial cells of spleen and liver. This unconjugated bilirubin is not soluble in water so is bound to albumin for its transfer in plasma.Liver uptakes this unconjugated bilirubin and conjugates it with glucuronic acid generating bilirubin glucuronide which is water soluble.For more on this topic see Question no. 12 Nov. 1999