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What is Which of the following is not true regarding super-antigens - and explain in detail?
Superantigens Superantigens are potent activators of T-lymphocytes. Superantigens stimulate very large numbers of T cells, without relation to their epitope specificity. This leads to an excessive and dysregulated immune response with release of cytokines IL - 1, IL - 2, TNF - a and IF - y. Superantigens are capable of activating up to 20% of the peripheral T-cell pool, where as conventional antigens activate < 1 in 10, 000. For superantigens, antigen specificity of TCR is not required.