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What is The most likely complication of prolonged use of nasal decongestant drops is and explain in detail?
NASAL DECONGESTANTS These are a agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction. The imidazoline compounds-- naphazoline, xylometazoline and oxymetazoline are relatively selective a2 agonist (like clonidine). They have a longer duration of action (12 hours) than ephedrine. side effects:- They may cause initial stinging sensation (Especially naphazoline). Regular use of these agents for long periods should be avoided because mucosal ciliary function is impaired: atrophic rhinitis and anosmia can occur due to persistent vasoconstriction. They can be absorbed from the nose and produce systemic effects, mainly CNS depression and rise in BP. cautious use:- These drugs should be used cautiously in hypeensives and in those receiving MAO inhibitors. Ref:- kd tripathi; pg num:-136