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What is Gluten-sensitive enteropathy is most strongly associated with – and explain in detail?
Almost all individuals with celiac disease share the major histocompatibility complex II HLA-DQ2 or HLA-DQ8.
Gliadin is deamidated by the enzyme transglutaminase and deamidated gliadin peptides bind to DQ2 and DQ8.
Recognition of these peptides by CD4+ T cells leads to secretion of IFN-γ, which damages the intestinal wall.