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What is Dilantin causes? and explain in detail?
Folic acid deficiency REF: KDT 7th ed p. 405 Adverse effects of phenytoin (Dilantin): At therapeutic levels At high plasma levels * * Gum hyperophy Hirsutism * Cerebellar side effects : ataxia, veigo, diplopia, nystagmus * * Hypersensitivity reactions Megaloblastic anemia due to folate deficiency * Drowsiness , behavorial alterations , hallucinations , disorientation , rigidity * Osteomalacia due to decreased in target sensitivity to * Epigastric pain vit. D * Local vascular damage may be caused by * Interferes with insulin release and hyperglycemia phenytoin * Fetal hydantoin syndrome: hypoplastic phalanges, cleft palate, hair lip, microcephaly. * Fall in BP