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What is An anti-arrhythmic drug that is not proarrhythmic? and explain in detail?
Ans. a (Lignocaine). (Ref. KD Tripathi, Pharmacology, 6th /513)# Most anti-arrhythmic can themselves precipitate serious arrhythmias i.e., they have arrhythmogenic potential, hence called proarrhythmic.- Encainide, flecainide, moricizine have higher incidence of sudden death.# Terfenadine, astemizole, cisapride and halofantrine prolong QT interval; co-admin of class la drugs (Quinidine, procainamide, disopyramide, moricizine) or sotalol carries high risk of Torsade de Pointes.Lignocaine has minimal effect on normal ECG and it has no significant autonomic action.