You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 7-year old boy with left renal mass had bone pain and was detected to have bone metastatic deposits. The most likely renal tumor is - and explain in detail?
Ans. is 'c' i.e., Clear cell sarcoma Clear cell carcinoma is a histological subtype of Wilm's tumour which frequently metastasize to bone (hi conventional wilms's tumour bone metastasis is rare). Histology of wilms tumor o Wilms tumor is a complex mixed embryonal neoplasm, comprises three elements : ? i) Blastema ii) Mesenchyme iii) Epithelium o On the basis of outcome Wilms tumor has been classified into two histological subtypes : ? 1. Favourable histology o It is the conventional form and carries good prognosis. o Comprises blastoma, epithelial and stromal elements. o Devoid of anaplasia or ectopia. o Brain and bone metastasis is rare. o Metastasis may occur to lung. 2. Unorable histology o Characterized by marked enlargement of nuclei, hyperchromatism, and multipolar mitotic figures. o Anaplasia is present. o Clear cell sarcoma is a subtype of the unorable form and usually metastasizes to bone. Note : o Rhabdoid tumor, which may metastatize to the brain, is no longer classified as a subtype of wilms tumor.