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What is Which of the following sulphonamides is available as an oral preparation? and explain in detail?
Sulfadiazine is a sulfonamide which can used orally, as it is rapidly absorbed & rapidly excreted. It is 50% plasma protein bound & 20-40% acetylated. It has good penetration in CSF & brain, therefore used in the treatment of meningitis. Ref: Essentials of Medical Pharmacology, 5th Edition, Pages 641-3