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What is b-blockers with intrinsic sympathomimetic propeies are - and explain in detail?
Ans. is 'b' i.e., Oxprenolol Beta-blockers with intrinsic sympatheomimetic (paial agonist) activity :? 1.Acebutolol 3. Pindolol 5. Penbutolol 7. Alprenolol 9. Celiprolol 2. Caeolol 4. Bipindolol 6. Oxprenolol 8. Labetalol o These drugs are paial agonists at b1 receptors (apa from having [b-blocking propey). These are preferred in patients prone to develop severe bradycardia with b-blockers therapy as they are b1 agonists (Hea receptor) --> stimulating action on hea --> No bradycardia. However, In angina patient, they might precipitate MI due to stimulation of hea should be avoided in angina patients. o Pindolol has maximum intrinsic symathomimetic activity (most potent paial agonist).