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What is Most common cause of umblicus does not separate at age of 2 years. and explain in detail?
(Leukocyte adhesion deficiency) (1289- B & L 24th) (61-62-Basis pathology 7th) (985-Baily & Love 25th)* Leukocyte adhesion deficiency (LAD-1)- Defects in b chain of CD 11 /CD 18 integrins- Characterised by recurrent bacterial infections and impaired wound healing* Leukocyte adhesion deficiency (LAD-2)- Defect in fucosyl transferase required for synthesis of sialylated oligosaccharide- Characterised by recurrent bacterial infections* Raspberry tumour - (Umbilical adenoma) - due to a partially (occasionally completely) unobliterated vitellointestinal duct. Mucosa prolapsing through the umbilicus gives rise to a raspberry like tumour, which is moist and tends to bleed - Treatment umbilectomy