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What is Bilateral Renal cell carcimoma is seen in and explain in detail?
VHL syndrome: Autosomal dominant cancer syndrome, characterized by: Cerebellar hemangioblastomas Retinal angiomas Clear cell RCC Pheochromocytoma Cysts in various organs. Patients of VHL disease have germline mutations of tumor suppressor VHL gene located on chromosome 3p, commonly as homozygous loss of the VHL gene. About 35% of cases of VHL develop RCC. Ref: Ram Das Nayak 2nd edition page no: 633