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What is The most common cardiovascular lesion in Down&;s syndrome is: and explain in detail?
The most common cardiovascular lesion in Down&;s syndrome is endocardial cushion defect. Other associated defects are atrial septum defects(ASD), ventricular septum defect(VSD), and patent ductus aeriosus(PDA), aberrant subclan aery, and pulmonary hypeension. Clinical Features: Intellectual disability/Incurved or sho fifth finger with clinodactyly Congenital hea disease Acute megakaryoblastic leukemia/Alzheimer&;s disease/Atlantoaxial instability/Atresia of the duodenum Protruding tongue Round face Occiput flat/Open wide fontanelle/Open mouth Brachycephalic/Brushfiel&;s spots Low (depressed) nasal bridge Epicanthal fold/Ears low set and dysplastic Mongoloid slant (Oblique palpebral fissure) Simian palmar crease and wider gap between first and second toes. Ref: Nelson textbook of pediatrics 21st edition Pgno: 660