You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Therapeutic drug monitoring of Theophylline, when used clinically in Asthma, is because? and explain in detail?
ANSWER: (A) Narrow therapeutic marginREF: KDT 6th edition page 35, 221, Katzung 12" edition page 339Theophylline should be used only when therapeutic drug monitoring available because it has narrow therapeutic window.Therapeutic drug monitoring (TDM) is particularly useful in the following situations:Drugs with low safety margin-digoxin, anticonvulsants, antiarrhythmics, theophylline,aminoglycoside antibiotics, lithium, tricyclic antidepressants.If individual variations are large; antidepressants; lithium.Potentially toxic drugs used in the presence of renal failure; aminoglycoside antibiotics, vancomycm.In case of poisoning.In case of failure of response without any apparent reason; antimicrobials.To check patient compliance; psychopharmacological agents.