You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Rationale of not using ACE inhibitor with spironolactone is? and explain in detail?
ANSWER.: (A) HyperkalemiaREF: KDT 6th edition page 484, Katzung 12 th edition page 185ACE inhibitors are contraindicated with potassium supplements and potassium sparing diuretics (spironolactone) because they can cause dangerous hyperkalemia.ACE inhibitors are also contraindicated with NSAIDs because they attenuate the hypotensive action.ACE inhibitors increases the lithium toxicity by reducing the lithium clearanceACE inhibitors + Diuretics+ NSAIDs combination contraindicated as they can cause renal failure.