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What is In Leprosy most common renal lesion seen is: and explain in detail?
Ans:A.)MGN The most common renal manifestation in leprosy patients is glomerulonephritis.. Glomerulonephritis is a renal disease in which immune-mediated glomerular damage is the initiating factor. Proliferative glomerulonephritis is characterized by proliferation of the mesangial cells with an influx of inflammatory cells. Membranous glomerulonephritis is characterized by accumulation of matrix and thickening of the glomerular basement membrane (GBM) and capillary wall. A study , with 72 leprosy patients undergoing renal biopsy found the following histopathological patterns: membranous nephropathy (31.5%) and mesangioproliferative glomerulonephritis (11.1%). Other renal lesions that have been described include amyloidosis, tubulointerstitial disease, acute renal failure, and functional defects in the absence of identifiable histologic abnormalities.