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What is Regarding aprepitant all are true execpt: and explain in detail?
Aprepitant is a highly selective NK1 receptor antagonist orally active and enter the brain. It is used in treating and preventing chemotherapy induced emesis. It is metabolized by CYP3A4 enzymes and can also inhibit the metabolism of drugs metabolized by this enzyme e.g.warfarin.(Katzung 11/e p 1086,Goodman and Gilman 11/ep650)