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What is Calcium channel blocker causing cerebral vasodilatation is:- and explain in detail?
Nimodipine (DHPs)- Blocks Ca2+ channel only in cerebral blood vessels-Cerebral vasodilation Used in subarachnoid hemorrhage (SAH). Felodipine is approved for Tx of Raynaud's disease. Amlodipine has higher oral bioavailability- used in hypeension Nitrendipine - it has been shown to release NO from endothelium & inhibit cAMP phosphodiesterase - vasodilation - indicated in hypeension & angina pectoris.