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What is Onion skin thickening of aeriolar wall is seen in- and explain in detail?
Lyme ahritis develops in roughly 60% to 80% of untreated patients and is the dominant feature of late disease. The ahritis may be caused by immune responses against Borrelia antigens that cross-react with proteins in the joints, but the exact mechanisms are not yet understood. The disease tends to be migratory, with remissions and relapses. It involves mainly large joints, especially the knees, shoulders, elbows, and ankles, in descending order of frequency. Histologic examination reveals a chronic papillary synovitis with synoviocyte hyperplasia, fibrin deposition, mononuclear cell infiltrates, and onion-skin thickening of aerial walls; (Robbins Basic pathology,9th edition.pg no.790)