You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The commonest mode of inheritance of Von Willebrand's disease : and explain in detail?
Answer is C (Autosomal dominant) There are 3 major forms of Von WilleBrand's disease and with one exception i.e. type III all forms are inherited as autosomal dominant trait- Harrison 16th/676 Von WilleBrand's disease is the most common hereditary coagulation disorder characterized by a quantitative or qualitative defect in Von Willebrand's factor Factor VIII circulates in blood as a complex with vWF Propey VWF Factor VIII Gene Located on ()chromosome XII Located on (-2 X chromosome Inheritance Autosomal dominant Q Sex linked () Synthesis Endothelial cells. megakaryocytes platelets (not in liver cells) (2 In liver cells (-) Function Facilitate the adhesion of platelets to subendothelial collagen V. W. disease Activation of factor X in coagulation cascade. Hemophillia Disease