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What is Which of the following drug is implicated in the causation of osteomalacia of the bone? and explain in detail?
Phenytoin inhibit the hepatic production of 25 hydroxy vitamin D and also directly inhibit bone mineralization and thus may result in osteomalacia. Steroids and heparin result in osteoporosis not osteomalacia. Impoant drugs causing osteomalacia are: Phenytoi Carbamazepine Valproate Phenobarbitone Bisphosphonates