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What is The enzyme involved in the activation for fatty acids beta oxidation is? and explain in detail?
Fatty acids must first be conveed to an active intermediate before oxidation. This is the only step in the oxidation of a fatty acid that requires energy from ATP. In the presence of ATP and coenzyme A, the enzyme acyl-CoA synthetase (thiokinase) catalyzes the conversion of fatty acid (or FFA) to an "active fatty acid" or acyl-CoA, using one high-energy phosphate and forming AMP and PPi. The PPi is hydrolyzed by inorganic pyrophosphatase with the loss of a fuher high-energy phosphate, ensuring that the overall reaction goes to completion. Acyl-CoA synthetases are found in the endoplasmic reticulum, peroxisomes, and on the outer membrane of mitochondria.