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What is Singer&;s Alkali denatuaion test is performed for: and explain in detail?
Singer&;s alkali denaturation test is performed for Vasa Pre. Detection of nucleated RBCs using apt test or Singer&;s alkali denaturation test is diagnostic of vasa pre. It is based on the fact that fetal hemoglobin is resistant to alkali denaturation. Both Apt and Kleihauer-Betke Test can be used to detect the presence of fetal blood within a sample. Apt Test Kleihauer Betke Test Reagent NaOH Citric acid Phosphate buffer Assessment Qualitative Quantitative Ref: DC Dutta&;s textbook of Obstetrics 8th edition Pgno: 301