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What is Investigation of choice to diagnosis Hirschsprug's disease is: and explain in detail?
Ans. is 'c' i.e. Rectal biopsy RepeatYou already know about the features of Hirschsprung's disease seen on contrast enema from the question asked earlierMore about the diagnosis of Hirschsprung's disease -Definitive diagnosis of Hirschsprung's disease is made by Rectal biopsy :It demonstrates following features-Absence of ganglion cells in Meissner's plexus, and myenteric plexusHypertrophy of nerve trunksManometric study - Manometric studies will show a failure of relaxation of internal sphincter following rectal distension.