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What is Vigabatrin acts by: and explain in detail?
(Ref: Katzung, 14th ed. pg. 431-32)* VIGABATRIN is GABAergic drug acts by inhibiting enzyme GABA transaminase.* This enzyme inhibition causes increased level of GABA in the neuron.* Use:# DOC in infantile spasm + Tuberous sclerosis# Simple and complex partial seizure* Contraindicated in absence seizure, Myoclonic seizure, Pre-existing visual field defect.* Side effect: Visual field defect due to peripheral retinal atrophy, weight gain, amnesia* GABA uptake transport inhibitor: TIAGABINE