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What is Patient was given chloroquine and doxycycline for 7 days. Patient's fever decreased in 4 days, but, peripheral smear showed occasional gametocytes of Plasmodium falciparum. This type of drug resistance is ? and explain in detail?
Ans. is 'b' i.e., R2 type WHO classification of antimalarial drug resistance 1. S-sensitive --> If a sexual parasites have cleared by day 6 from the begining of treatment wihout subsequent recrudescence until day 28. 2. R1-Low grade resistance --> Recrudescence of infection between 7-28 days of completing treatment. 3. R2 High grade resistance --> Reduction of parasitemia by more than 75% at 48 hours of completing treatment but failure to clear the organism within 7 days. 4. R3-> Parasitemia does not fall by more than 75% within 48 hours of completing treatment and there is no subsequant clearance of asexual parasites.