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What is Most common cause of cervical neoplasia is and explain in detail?
Human papilloma virus *Oncogenic DNA virus which are grouped into high and oncogenic risk HPVs*High oncogenic risk HPVs(HPV16 and 18) -main cause of cervical cancers and also vaginal, vulvar, penile, anal, tonsillar and oropharyngeal carcinomas.*Low oncogenic risk HPVs (HPV 6 and 11) - causes vulvar, perineal and perianal condyloma accuminatum.*HPV produce two envelope proteins-E6 and E7. *E6 proteins inhibits p53, induce centrosome duplication, induce genomic instability and upregulates telomerase.*E7 promotes cell cycle by binding to RB and upregulates cyclin E, induce centrosome duplication and induce genomic instability (Ref: Robbins 8/e p1018)