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What is Which one of the following is not a feature of multiple myeloma - and explain in detail?
In multiple myeloma , hypercalcaemia is due to destruction of bone. Anaemia is due to marrow replacement by tumor cells & inhibition of hematopoiesis. Hyperviscosity is due to hyperglobulinaemia & produce headache,fatigue,visual disturbance & hemorrhage.In the absence of fractures , plasma alkaline phosphatase & isotope bone scan will be normal despite lytic lesions.Reference : Harsh mohan textbook of pathology 6th edition pg no 383 & Davidson's principle & practice of medicine 22nd edition pg no1046.