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What is 80 year old, asymptomatic man present with a Total Leucocyte Count of 1 lakh, with 80% lymphocytes and 20% PMC's. What is the most probable diagnosis? and explain in detail?
Answer is C (CLL) : Incidental finding of Lymphocytosis (80,000/mcL) in an elderly and' asymptomatic patient suggests the diagnosis of CLL. Why is CLL the single best answer of choice here ? 'CLL is a disease of older patients wth 90% of cases occurring after the age of 50 years and median age of presentation is 65 years'. - CMDT The patient in question is aged 80 years and hence falls in the bracket of CLL. 'Typical B cell CLL is often, lbund incidentally when a complete blood count is done for another reason'. The patient in question is asymptomatic and the findings represent incidental observation on a full blood count done for an obscure reason. 'The hallmark of CLL is absolute lymphocytosis. White cell count is usually greater than 20,000/mcL may be markedly elevated to several 100,000/ma,. Usually 75-80% of circulating cells are lymphocytes'. - CMDT The patient in question is presenting with a white cell count of 100,000/mcL and 80% of circulating cells are lymphocytes. This finding is consistent