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What is Waldenstrom's macroglobulinemia is seen in and explain in detail?
Waldenstrom Macroglobulinemia B cell neoplasm in 6th or 7th decade of life similar to CLL/SLE and multiple myelomaGenetics - Deletion of chromosome 6qNeoplastic infiltrates into organs like spleen, lymph node & bone marrowBalanced production of light and heavy chains thereby decreasing the development of renal failure or amyloidosisBlood - anemia, atypical plasmacytoid lymphocytes, | ESR, rouleaux formation Immunoelectrophoresis - Presence of "M" or monoclonal spikeBone marrow - plasmacytoid infiltrates, PAS + inclusions, Russell bodies ( cytoplasmic Ig), Dutcher bodies ( nuclear Ig )Immunophenotyping - CD 20 +, CD 5- and CD 10-(Refer: Robbins & Cotran's - Pathologic Basis of Disease, SAE, 1st edition, Vol I-pg no: 598-599)