You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Aspirin in very low doses inhibits the formation of:- and explain in detail?
Aspirin inhibits COX enzyme irreversibly and thus results in decreased synthesis of TXA2 as well as PGI2. TXA2 is produced by platelets and as platelets do not contain nuclei, TXA2 is not synthesized till there is production of fresh platelets, whereas vessel wall contains nucleus and thus can resume the synthesis of enzymes required for the formation of prostacyclins. The net effect is inhibition of TXA2 synthesis leading to anti-aggregatory effects.