You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The following statements regarding methylxanthines are true except: and explain in detail?
Methyl xanthines inhibit cyclic nucleotide phosphodiesterases and can antagonize receptor-mediated actions of adenosine.
Long-term ingestion of methyl xanthines can produce tolerance and physical dependence.
It can relax various smooth muscles including the bronchial muscles.
It increases glomerular ﬁltration rate and increases the excretion of electrolytes and water.