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What is With help of pyridoxine, serotonin is synthesized from which of the following precursor amino acid? and explain in detail?
Serotonin is synthesized from the essential amino acid tryptophan. The rate-limiting step is the conversion of the amino acid to 5-hydroxytrptophan by tryptophan hydroxylase. This is then conveed to serotonin by the aromatic L-amino acid decarboxylase. 5-hydroxyindoleacetic acid (5-HIAA). This substance is the principal urinary metabolite of serotonin. There are seven classes of 5-HT receptors (from 5-HT1 through 5-HT7 receptors). Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 7. Neurotransmitters & Neuromodulators. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.