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What is Following statement is true for hemophilia patients? and explain in detail?
Ans. is 'c' i.e., Females are mostly carriers and all males are affected Hemophilia is an X-linked recessive hemorrhagic disease due to mutations in the F8 gene (hemophilia A or classic hemophilia) or F9 gene (hemophilia B). The disease affects I in 10,000 males worldwide, in all ethnic groups; hemophilia A represents 80% of all cases. Male subjects are clinically affected; women, who carry a single mutated gene, are generally asymptomatic. Family history of the disease is absent in 30% of cases and in these cases, 80% of the mothers are carriers of the de novo mutated allele.