You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is In wof Wickham&;s striae are seen and explain in detail?
Lichen Planus * Pruritic papular disease of skin and mucous membranes * Due to cell-mediated autoimmune reaction toward basal layer keratino-cytes; may be idiopathic, drug-related or infection-related (HCV) * 4P's: papular, pruritic, polygonal, purple * Often lasts 1-2 years (except oral and hyperophic forms, which typically have protracted courses) * Presents with intense pruritus and violaceous, smooth flat-topped papules and plaques with fine scale (Wickham's striae) over flexor wrists, forearms, legs, presacrum and other areas, + Koebner phenomenon * No conclusive evidence to suppo association with autoimmune disease (per Bolognia); difficult to determine if true HLA association Histology:- * Hyperkeratosis (without parakeratosis) * | Granular layer * Paially effaced rete ridges with widened papillae ('sawtooth' appearance) * Vacuolar change of basal layer with colloid bodies * Band-like lymphocytic infiltrate at dermoepidemal junction * Dermal melanophages Treatment:- superpotent topical coicosteroids, topical calcineurin inhibi tors, intralesional or systemic coicosteroid, phototherapy, methotrexate, acitretin, metronidazole (latter for erosive oral form). Ref:- Sima Jain; pg num:- 106,108