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What is A person was given a muscle relaxant that competitively blocks nicotinic receptors. Which of the following drugs is used for reversal of muscle relaxation after surgery? and explain in detail?
Reversal agent Anticholinesterase Agent: Neostigmine- it is reversible acetylcholinesterase inhibitor . This inhibition is present at all cholinergic synapses so has potent parasympathetic activity. Thus given, accompanied with Atropine/ glycoprolate. MOA- It inactivates the enzyme acetylcholinesterase which is responsible for break down of acetylcholine thus increasing the amount of acetylcholine available for competition with non depolarizing agent thereby reestablishing neuromuscular transmission. Dose-0.035- 0.05 mg/kg Peak effect- 1 to 2 min