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What is True about atherosclerosis ? and explain in detail?
Ans. is 'a' i.e., Chronic inflammatory disorder of vessel wall Facts about atherosclerosis Is a chronic inflammatory and healing response of the aerial wall to endothelial injury.Atherosclerosis progresses in the following sequence:Endothelial injury and dysfunction - Accumulation of lipoproteins (mainly LDL) Monocyte adhesion to the endothelium, followed by migration into the intima and transformation into macrophages and foam cells - Platelet adhesion factor release from activated platelets, macrophages, and vascular wall cells - Smooth muscle cell proliferation, extracellular matrix production, and recruitment of T cells - Lipid accumulation both extracellularly and within cells (macrophages and smooth muscle cell).In descending order, the most extensively involved vessels are the lower abdominal aoa, the coronary aeries, the popliteal aeries, the internal carotid aeries, and the vessels of the circle of Willis. In humans, the abdominal aoa is typically involved to a much greater degree than the thoracic aoa.