You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which apolipoprotein is responsible for Alzeihmers disease and explain in detail?
* Familial AD and Apo-E4 gene: There is an association between patients possessing the apo E4 allele and the incidence of Alzheimer disease. Apparently, apo E4 binds more avidly to beta-amyloid found in neuritic plaques. * Genes identified with AD are that coding for APP, presenilin-1 (chromosome 14), presenilin-2 (chromosome 1) or AD3 (chromosome 14) or AD4 (chromosome 1), and Apo-E4 gene (chromosome 19). * The presence of Apo-E4 gene is the major risk factor for AD. Apo-E2 gene reduces the risk of AD. Ref:- Harper 30/e; pg num:- 275