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What is Mallory Hyaline is characteristically seen with and explain in detail?
ALCOHOLIC HEPATITIS. Alcoholic hepatitis develops acutely, usually following a bout of heavy drinking. Repeated episodes of alcoholic hepatitis superimposed on pre-existing fatty liver are almost ceainly a forerunner of alcoholic cirrhosis. Histologically, the features of alcoholic hepatitis are as follows : i)Hepatocellular necrosis: Single or small clusters of hepatocytes, especially in the centrilobular area (zone 3), undergo ballooning degeneration and necrosis. ii)Mallory bodies or alcoholic hyalin: These are eosinophilic, intracytoplasmic inclusions seen in perinuclear location within swollen and ballooned hepatocytes. Mallory bodies are also found in ceain other conditions such as: primary biliary cirrhosis, Indian childhood cirrhosis, cholestatic syndromes, Wilson's disease, intestinal bypass surgery, focal nodular hyperplasia and hepatocellular carcinoma. TEXTBOOK OF PATHOLOGY 6TH EDITION HARSH MOHAN PAGE NO:621,622