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What is A factor that is likely to increase the duration of action of a drug D that is partially metabolized by CYP3A4 in the liver is: and explain in detail?
- Microsomal enzyme inducers- Rifampicin, Phenobarbital- will increase the activity of enzymes, leading to decreased duration of action of a drug.
- Microsomal enzyme inhibitor- Cimetidine- will decrease the activity of enzyme resulting in increased duration of action of the drug.
- A drug displaced from the binding site gets easily metabolized.