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What is Glander&;s disease is caused by and explain in detail?
Glanders disease # Gram(-) bacillus, Burkholderia mallei # Caused by contact w/ infected horses or donkeys . Four forms: - * Localized--hemorrhagic, ulcerative papulopustule at inoculation site * Chronic--multiple soft tissue nodules ("farcy buds") on skin overlying lymphatics * Septicemic form--moality rate >95% without treatment and 50% w/ treatment * Pulmonary form--moality similar to septicemic form Treatment: - * Localized disease: 60- to 150-day course of amoxicillin/clavulanate, doxycycline, or TMP/SMX. * Septicemic: IV carbapenems + ciprofloxacin or doxycycline. Ref:- Review of Dermatology by Alikhan; pg num:-298