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What is DOC for smoking cessation? and explain in detail?
Ans. B. Varenicline (If Bupropion is not an option)Anti-smoking drugs:Bupropion (along with Varenicline & Nicotine replacement therapy) is a USFDA approved first-line agent for pharmacotherapy in smoking cessation.Varenicline:Effective agent for smoking cessation.Synthetic drug with paial agonist action at a4ss2 nicotinic receptors.Has antagonist propeies persisting due to long half-life & high receptor affinity.Hence, prevents stimulant effect of nicotine at presynaptic a4ss2 receptors a results in dopamine release.