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What is Retinoblastomas arising in the context of germ-line mutations not only may be bilateral, but also may be associated with______ (so called "trilateral" retinoblastoma) and explain in detail?
Ans. (b) Pinealoblastoma(Ref: Robbins 9th/pg 1339)*"Trilateral" retinoblastoma refers to bilateral Retinoblastomas pluspinealoblastoma, occurring in individuals inheriting a germline mutation of one RB allele; it is associated with a dismal outcome*Retinoblastoma is the most common primary intraocular malignancy of children.