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What is Endogenous pyrogens act by - and explain in detail?
Ans. is 'b' i.e., Raising thermostat point of hypothalamus o Bacterial toxins (exogenous pyrogens) stimulate inflammatory cells to secrete pyrogenic cytokines (endogenous pyrogens), e.g. IL-1, TNF-a , and IL-6.o These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever.Endotoxin inflammationOther pyrogenic stimuli|MonocytesMacrophagesKupffer cells| CytokinasePreoptic area of hypothalamus| ProstaglandinsRaise temperature set point|FeverPathogenesis of fever