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What is Veical transmission of toxoplasmosis most commonly occurs during which stage of pregnancy? and explain in detail?
Veical transmission of toxoplasmosis is maximum in the third trimester (60%). Risk of fetal transmission of infection during first trimester is 15% and 30% during second trimester. Fetus is at risk of infection only when the mother is seronegative. Affected babies develop hydrocephalus, choroidoretinitis, cerebral calcification, microcephaly and mental retardation. Presence of IgM antinody in neonates indicates congenital infection.