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What is A 45-year-old man presents with a 9-month history of a reddish nodule on his foot. Biopsy of the nodule discloses a poorly demarcated lesion composed of fibroblasts and endothelial-like cells lining vascular spaces. Further work-up identifies similar lesions in the lymph nodes and liver. The tumor cells contain sequences of human herpesvirus-8 (HHV-8). This patient most likely has which of the following diseases? and explain in detail?
Kaposi sarcoma is the most common neoplasm associated with acquired immunodeficiency syndrome (AIDS). The neoplastic cells contain sequences of a novel virus, HHV-8, which is also known as Kaposi sarcoma-associated herpesvirus. In addition to infecting the spindle cells of Kaposi sarcoma, HHV-8 is lymphotropic and has been implicated in two uncommon B-cell lymphoid malignancies, namely, primary effusion lymphoma and multicentric Castleman disease. Like other DNA viruses, the HHV-8 genome encodes proteins that interfere with the p53 and pRb tumor suppressor pathways. The other choices are hereditary conditions associated with cancer; however, these patients do not typically acquire Kaposi sarcoma. The predominant malignancy seen in patients with ataxia telangiectasia (choice B) is lymphoma/leukemia.Diagnosis: Kaposi sarcoma, AIDS