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What is Human leukocyte antigen (HLA) which plays an impoant role in graft rejection is present on chromosome: and explain in detail?
The genes for the HLA antigens are clustered in the major histocompatibility complex (MHC), located on the sho arm of chromosome 6. Three of these genes (HLA-A, HLA-B, and HLA-C) code for the class I MHC proteins. Several HLA-D loci determine the class II MHC proteins (i.e., DP, DQ, and DR). Ref: Levinson W. (2012). Chapter 62. Major Histocompatibility Complex & Transplantation. In W. Levinson (Ed), Review of Medical Microbiology & Immunology, 12e.