You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Testotoxicosis is due to and explain in detail?
Testotoxicosis is an interesting disease that combines gain and loss of function. In this condition, an activating mutation of Gs a causes excess testosterone secretion and prepubeal sexual maturation. However, this mutation is temperature-sensitive and is active only at the relatively low temperature of the testes (33 degC). At 37 degC, the normal temperature of the rest of the body, it is replaced by loss of function, with the production of hypoparathyroidism and decreased responsiveness to TSH.