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What is Which of the following is TRUE about rheumatoid factor? and explain in detail?
Rheumatoid factors (RFs) are autoantibodies, predominantly IgM isotype (19s IgM), that are directed against multispecies antigenic determinants on the heavy chain of IgG. RFs can arise as an epiphenomenon during acute illness or chronic antigenic stimulation of almost any cause. They are present, in significant titer, in bacterial endocarditis, granulomatous diseases, and most rheumatic diseases. Ref: Textbook of Microbiology By Ananthanarayan And Paniker, 2005, Page 174.