You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Insulin dependent glucose uptake occurs in: and explain in detail?
Insulin causes inseion of GLUT-4 transpoers into the membranes of muscle cells and adipocytes. Glucose entry into these cells occurs GLUT-4 transpoers; it is an insulin-dependent transpo. Epithelial cells of the small intestine have SGLT-1 (sodium-glucose transpoer) which causes co-transpo of glucose with sodium, from intestinal lumen into the epithelial cell. Then, GLUT-2 causes facilitated transpo of glucose from the cell into blood. GLUT-2 mediated glucose transpo is not insulin-dependent. GLUT-2 is also present in pancreatic b-cell, liver. GLUT-2 is an impoant glucose transpoer during fasting-to-fed state. Glucose transpo in renal tubular cells occurs SGLT-2 and SGLT-3; a co-transpo along with sodium. Neuronal tissue has GLUT-3 for the glucose transpo. Brain is an obligate glucose user. Its functioning is critically dependent on circulating blood glucose level. Glucose entry into nerve cells is not insulin-dependent.