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What is Which among the following drug is used in benign prostatic hyperplasia? and explain in detail?
Ans: b (Tamsulosin) Ref: KDT, 6 ed, p. 135Tamsulosin:Uroselective alpha 1A blocker (alpha 1A: alpha 1B = 1:7-38 fold) for BPH.No significant change in HR & BP: postural hypotension.A/E: Retrograde ejaculation, dizziness.Flutamide:Competitive blocker of androgen receptor.Use: Palliative role in prostate cancer along with GnRH agonism.A/E: Gynaecomastia. breast tenderness.Finasteride:5 alpha reductase (Type 2) inhibitor in male urogenital tract.Results in decreased prostatic size & increased peak urinary flow rate in about 50% patients with symptomatic benign hypertrophy of prostate.6 months treatment needed for maximum relief.A/E: Decreased libido, impotence, decreased ejaculate volume.