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What is All of the following statements regarding the mechanism of action of combined oral contraceptive drugs are TRUE, EXCEPT: and explain in detail?
It is the progesterone content and not the estrogen content of OCP which modifies tubal and uterine contractions and prevent feilization. Mechanism of action of OCPs: Inhibition of ovulation: Oestrogen decreases FSH release and progesterone decreases LH release. Progestins cause thickening of cervical mucus and prevent sperm passage Progesterone modifies the tubal and uterine contractions and prevent feilization Failure of implantation: Estrogen makes the endometrium hyperproliferative and hypersecretory, whereas progesterone makes it atrophied and hyposecretory. Ref: Basic Undergraduate Pharmacology By Sudeb Mondal page 247.