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What is Which of the following markers is specific for Gastro intestinal stromal tumors (GIST)? and explain in detail?
CD 117 is most specific marker for Gastrolintestinal stromal tumor, than CD 34. GIST has a universal expression of CD117. It can also be present in fibroblastic and endothelail tumors. Ref: M. Wasif Saif (2010), Chapter "Gastrointestinal Stromal Tumors", In the book, "Gastrointestinal Malignancies", Volume 1, Issue 1, USA, Page 152; Robbin's Basic Pathology, 7th Edition, Page 826; Oncology: An Evidence Based Approach, (2006), Pages 413-14; Sternberg's-Diagnostic Surgical Pathology, 4th Edition, Page 1590