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What is A 20-year-old woman was diagnosed 8 years earlier with precocious pseudo-pubey secondary to ovarian tumour.Physical examination reveals oral and lingual dark pigmentation. Patient also has multiple polyps throughout gastro intestinal.Histopathological finding: polyps show arborization and pseudo invasion. The most common site of these polyps is and explain in detail?
A- COLON B- JEJUNUM C- ILEUM Intestinal polyposis with arborization and pseudoinvasion are characteristic feature of Peutz-jeghers syndrome. The syndrome is characterised by: Multiple hamaomatous polyps throughout gastrointestinal tract (most commonly the jejunum Associated with tumours of ovary, breast, pancreas and endometrium. Hypermelanotic macules on the lips and palate. The syndrome is caused by loss of function mutations in STK11 gene.