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What is Select the drug which is a potassium channel opener as well as nitric oxide donor and explain in detail?
POTASSIUM CHANNEL OPENERS Nicorandil:- It activates ATP sensitive K+ channels (KATP) thereby hyperpolarizing vascular smooth muscle. Like nitrates it also acts as a NO donor--relaxes blood vessels by increasing cGMP. Thus, aerial dilatation is coupled with venodilatation. Coronary flow is increased; dilatation of both epicardial conducting vessels and deeper resistance vessels has been demonstrated. Nicorandil is believed to exe cardioprotective action by simulating 'ischaemic preconditioning' as a result of activation of mitochondrial KATP channels. Ischaemic preconditioning in a phenomenon in which brief periods of ischaemia and reperfusion exe a cardioprotective effect on subsequent total vascular occlusion, and involves opening of mito.KATP channels. Ref:- kd tripathi; pg num:-552