You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Primary hyperaldosteronism (Conn's syndrome) is characterized by- and explain in detail?
high aldosterone and low renin because as there is hypo secretion of renin that fails to increase appropriately during volume depletion and hyper secretion of aldosterone that does not suppress in response to volume expansion (Harrison 17 pg 2260)