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What is Which one of the following laboratory tests differentiates leukemoid reaction from chronic myeloid leukemia? and explain in detail?
<p>Leucocyte alkaline phosphate score in the cytoplasm of mature neutrophils in leukamoid reaction is characteristically high & ia very useful to distinguish it from CML. Leukaemoid reaction is defined as reactive excessive leucocytosis in response to infections,intoxication ,malignant disease ,& in severe hemmorhage & hemolysis.So mature neutrophils will be more resulting in elevated LAP.But in CML,mature neutrophils will be reduced resulting in low LAP score. </p><p>Reference :Harsh mohan textbook of pathology sixth edition pg no 353.</p>