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What is Phosphorylation of phosphofructokinase and fructose-1,6-bisphosphate by fructose-2,6-bisphosphate regulation is seen in and explain in detail?
Fructose-2,6-bisphosphate (F-2,6-BP) increases the activity of phosphofructokinaseF-2,6-BP is formed from fructose-6-phosphate by the action of an enzyme called PFK-2. (It is different from the PFK1)Fructose-2,6bisphosphate is hydrolysed to fructose-6phosphate by fructose-2,6-BisphosphataseThe activities of both the enzymes (PFK2 and fructose-2,6-bisphosphatase) are reciprocally regulated.When glucose supply is in plenty, PFK-2 is dephosphorylated and activated; so F2,6-BP concentration increases; this, in turn, activates PFK. Thus glycolysis is ored Ref: DM Vasudevan, 6th edition, page no: 98-99