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What is An infant presents with the condition as shown below after a pharyngeal infection. The shown condition is: and explain in detail?
SSSS/ Pemphigus Neonatorum / Ritter's disease: - Caused by: Staph. aureus - Seen in neonates and infants - Usually follows pharyngeal infection. - Staph. aureus releases Exfoliative toxins A & B that destroys Desmoglein 1 - Mucosal involvement absent - Epidermal separation occurs superficially. - Nikolsky sign positive - when pressure applied tangentially to skin, overlying epidermis will separate. Treatment of SSSS - Usually requires hospitalisation i/v antibiotics are given. A penicillinase-resistant, anti-staphylococcal antibiotic such as flucloxacillin is used. Other antibiotics include nafcillin, oxacillin, cephalosporin and clindamycin.