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What is Hereditary spherocytosis is caused by mutations in: and explain in detail?
Hereditary spherocytosis is caused by diverse mutations that lead to an insufficiency of membrane skeletal components. The pathogenic mutations most commonly affect ankyrin, band 3, spectrin, or band 4.2, the proteins involved in the first of the two tethering interactions, presumably because this complex is paicularly impoant in stabilizing the lipid bilayer. Ref: Robbins 8th edition Chapter 14.