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What is Sezary syndrome is included in category of- and explain in detail?
Sezary disease is a type of cutaneous lymphoma that was first described by Albe Sezary. The affected cells are T-cells (so it is a T-cell lymphoma) that have pathological quantities of mucopolysaccharides. Sezary disease is sometimes considered a late stage of mycosis fungoides with lymphadenopathy. There are currently no known causes of Sezary disease.Sezary syndrome and mycosis fungoides are T-cell lymphomas whose primary manifestation is in the skin. The disease's origin is a peripheral CD4+ T-lymphocyte,] although rarer CD8+/CD4- cases have been observed. Epidermotropism by neoplastic CD4+ lymphocytes with the formation of Pautrier's microabscesses is the hallmark sign of the disease.[ The dominant symptoms of the disease are: Generalized Lymphadenopathy Atypical T-cells ("Sezary cells") in the peripheral blood Hepatosplenomegaly