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What is Most common mitochondrial enzyme for metabolism detoxification reaction is ? and explain in detail?
Ans. is 'a' i.e., CYP 3A4 Subtypes of cytochrome P-450 Depending upon the extent of amino acid sequence homology, the cytochrome P-450 (CYP) isoenzymes are grouped into families designated by capital letters (A, B, C ....). Individual isoenzymes are again alloted numerals (1, 2, 3 ....). Examples are CYP1A2, 2A6, 2B6, 2C8, 3A4/3A5. In human beings, only a few members of three isoenzyme families carry out metabolism of most of the drugs. Cyp 3 A 4/5 carryout biotransformation of largest number (nearly 50%) of drugs. Impoant inducers of CYP 3A4/3A5 Barbiturates Glucocoicoids Rifampin Macrolide antibiotics Carbamazepine Phenytoin Pioglitazone