You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 24-year-old male presented with a swelling on anterior aspect of neck. On examination the swelling was firm and moved with deglutination. Biopsy from the lesion has been shown. What is the typical finding and diagnosis? and explain in detail?
Ans. (b) Orphan Annie eye nuclei; papillary Ca thyroid*High power shows nuclei of papillary carcinoma cells contain finely dispersed chromatin, which imparts an optically clear or empty appearance, giving rise to the ground glass or Orphan Annie eye nuclei. In addition, invaginations of the cytoplasm may give the appearance of intranuclear inclusions ("pseudoinclusions") or intranuclear grooves. The diagnosis of papillary carcinoma can be made based on these nuclear features, even in the absence of papillary architecture.