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What is Mechanism of action of sildenafil is: March 2012 and explain in detail?
Ans: C i.e. Phosphodiesterase-5 inhibitor Drugs and mechanism of action Finsateride is a competitive inhibitor of the enzyme 5 alpha reductase (which conves testosterone into more active dihydrotestosterone) Flutamide is a non-steroidal drug having specific anti-androgenic, but no other hormonal activity Sildenafil acts by selectively inhibiting PDE-5 and enhancing nitric oxide action in corpus cavernosum Danazol is an orally active ethisterone derivative having weak androgenic, anabolic and progestational activities.