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What is Plasminogen domain structurally resembles which of the following? and explain in detail?
Apo(a) of Lp(a) is structurally related to plasminogen and appears to be atherogenic by interfering with fibrinolysis of thrombi on the surfaces of plaques. Improant - Apo(a) shares a remarkable degree of homology with plasminogen in 3 main respects: a) multiple tandem repeats of domains similar to kringle four b) a single region resembling kringle five c) pseudoprotease segment. Plasminogen and apo(a) are genetically linked on chromosome 6 and may have arisen from a common ancestral gene. Ref: Hajjar K.A., Marcus A.J., Muller W.A. (2010). Chapter 117. Vascular Function in Hemostasis. In J.T. Prchal, K. Kaushansky, M.A. Lichtman, T.J. Kipps, U. Seligsohn (Eds), Williams Hematology, 8e.