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What is Fate of notochord is: and explain in detail?
Early in development, the embryonic mesoderm becomes differentiated into three distinct regions: paraxial mesoderm, intermediate mesoderm, and lateral mesoderm.The paraxial mesoderm gets divided into somites which gets differentiated into a ventromedial pa (the sclerotome) and a dorsolateral pa (the dermatomyotome).The dermatomyotome now fuher differentiates into the myotome and the dermatome.The mesenchymal cells of the sclerotome rapidly divide and migrate medially during the fouh week of development and surround the notochord.The caudal half of each sclerotome now fuses with the cephalic half of the immediately succeeding sclerotome to form the mesenchymal veebral body.Each veebral body is thus an intersegmental structure.The notochord degenerates completely in the region of the veebral body, but in the interveebral region, it enlarges to form the nucleus pulposus of the interveebral discs.The surrounding fibrocailage, the anulus fibrosus, of the interveebral disc is derived from sclerotomic mesenchyme situated between adjacent veebral bodies.