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What is Wire loop thickening of glomerular basement membrane is seen in - and explain in detail?
Ans. is 'a' i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis.