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What is Post translational modification in the form of sulfation of tyrosine residue happen in which GIT hormone: and explain in detail?
Post translational modification is responsible for ceain changes in the peptide structure of GIT hormones, eg: 1. Peptide cleavage to smaller forms occurs in case of somatostatin 2. Amidation of the carboxyterminus occurs in the case of Gastrin 3. Sulfation of the tyrosine residue in the case of CCK (Cholecystokinin). Sulfated CCK is 100 times more potent than normal CCK. Ref: Sleisenger and Fordtrans, Edition-9, Page -6.