You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Starry sky appearance is seen in - and explain in detail?
Ans. is 'a' i.e., Burkitts Lymphoma Burkitts lymphomao It includes (1) African (endemic) Burkitt lymphoma, (2) sporadic (nonendemic) Burkitt lymphoma, and (3 ) a subset of aggressive lymphomas occurring in individuals infected with HIV.o The involved tissues are effaced by a diffuse infiltrate of intermediate-sized lymphoid cells containing round or oval nuclei with coarse chromatin, several nucleoli, and a moderate amount of faintly basophilic or amphophilic cytoplasm .o The nuclear size approximates that of benign macrophages within the tumor.o A high mitotic index is typical, as is apoptotfc tumor cell death, accounting for the presence of numerous tissue macrophages with ingested nuclear debris.o These benign macrophages are diffusely distributed among the tumor cells and have abundant clear cytoplasm, creating a characteristic "starry sky" pattern.o All forms of Burkitt lymphoma are associated with translocations of the c-MYC gene on chromosome 8. The partner in the translocation is usually the IgH locus (t(8;14)) but may also be the k' (t(2;8)) or g (t(8;22)) light chain locus.o Essentially all endemic tumors are latently infected with EBV.