You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following Immunoglobulin is inactive when the temperature is raised? and explain in detail?
IgE is medically impoant for two reasons: It mediates immediate (anaphylactic) hypersensitivity, and It paicipates in host defenses against ceain parasites (e.g., helminths ). The Fc region of IgE binds to the surface of mast cells and basophils. IgE does not fix complement and does not cross the placenta. In contrast to other immunoglobulins, IgE is heat labile and gets inactivated by heating at 56degC Ref: Levinson W. (2012). Chapter 59. Antibodies. In W. Levinson (Ed), Review of Medical Microbiology & Immunology, 12e.