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What is A 70 kg young athlete was planned for surgery. During anaesthesia, vecuronium was not available, so repeated doses of succinylcholine was given intermittently up to 640 mg. During recovery, patient was not able to spontaneously respire and move limbs. What is the cause? and explain in detail?
Continued presence of the drug causes persistent depolarization resulting in flaccid paralysis-phase blockade 1. Phase 2 blockade is slow in onset and results from desensitization of of the receptor to A-ch. Psuedocholinestrase enzyme deficiency usual dose results in prolonged apnea and paralysis which lasts for hours. From padmaja 4th edition Page no 86 And from KD Tripati 7th edition Page no 349