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What is Crook's hyaline change occurs in - and explain in detail?
The pituitary in Cushing syndrome shows changes regardless of the cause.The most common change is Crooke hyaline change -the normal granular, basophilic cytoplasm of ACTH producing cells is replaced by homogenous, lightly basophilic material. This alteration is the result of the accumulation of intermediated keratin filament in the cytoplasm.