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What is HER2/neu receptor plays a role in and explain in detail?
Friends, direct quote from Robbins….’HER2/neu overexpression is associated with poorer survival but its main importance is as a predictor of response to agents that target this transmembrane protein (examples trastuzumab or lapatinib).’
• The overexpression is due to amplification of the gene HER2/neu located on 17q21. Ackerman writes…. HER2/new encodes a transmembrane glycoprotein with tyrosine kinase activity and its overexpression is a good predictor of response to herceptin (trastuzumab) but not a good predictor of response to chemotherapy or overall survival.