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What is 5 g mannitol was injected intravenously. 40% of mannitol is excreted. After equilibrium, plasma concentration of mannitol is 30 mg%. Calculate extracellular fluid volume. and explain in detail?
The volume of water in different compament can be measured by volume of distribution principle (indicator dilution principle). Where v = Volume of fluid Q = Quantity of indicator given C = Concentration of the indicator e = The amount of indicator which has either been lost or metabolized 30 mg% = 30 mg/ 100 mL = 300 mg/ L = 0.3g/L Quantity of mannitol excreted = 5 * 40/100 = 2 g ECF volume = 5 - 2 / 0.3 = 3 / 0.3 = 10 L