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What is Mechanism of action of sodium nitrite in cyanide poisoning: and explain in detail?
Ans. (A) Produces methemoglobinemia(Ref: KDT 8th/e p591)*Sodium nitroprusside contains one iron molecule coordinated to five cyanide molecules and one molecule of nitric oxide. Prolonged use of sodium nitroprusside may result in cyanide poisoning.*Detoxification occurs when cyanide and methemoglobin combine to form cyanomethemoglobin. Amyl nitrite or sodium nitrite enhance the oxidation of hemoglobin to methemoglobin, ensuring a reliable mechanism of detoxification.