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What is Which of the following are the adverse effects of pioglitazone? and explain in detail?
Glitazones - They act by stimulating PPAR- g receptor - Reverse insulin resistance - e.g. Pioglitazone Pioglitazone: -Adverse effects: Hepatotoxic Sodium and water retention weight gain Increases risk of urinary bladder carcinoma Avoid in liver disease or hea failure -Rosiglitazone increases the risk of myocardial infarction -Troglitazone banned because it cause liver damage