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What is Enzyme deficiency responsible for gout are all except: and explain in detail?
Ref: Harpers Illustrated Biochemistry,28th editionExplanation:Hyperuricemia - Uric acid level:Males > 7 mg / dLFemales > 6 mg / dLAccumulation of insoluble monosodium urate crystals in the synovial fluid causes inflammationAcute arthritis.Deposition in cooler areas - TophiRenal lithiasis.PRIMARY GOUT- CausesAbnormality in 5 - phosphoribosyl amido transferase.Abnormality in PRPP synthetase.Deficiency of enzymes of salvage pathway.Glucose-6-phosphatase deficiency.Increased activity of Glutathione reductaseSECONDARY GOUT- CausesIncreased turnover rate of nucleic acids.Leukemias, polycythemia.Treatment of Malignant tumors.Psoriasis.Reduced excretion rate.Renal failure.Thiazide diuretics.Lactic acidosis and Ketoacidosis.