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What is Which of the following is an example of Type IV hypersensitivity- and explain in detail?
Granulomatous reaction is a type of type 4. Example of Type IV hypersensitivity: Granuloma formation seen in: Tuberculosis, sarcoidosis, schistosomiasis and other trematode infections and Lepra reaction type I. Skin tests: Tuberculin test (Mantoux test / PPD test), Lepromin test, Montenegro test (leishmaniasis), Frie test (LGV). Contact dermatitis Chronic transplant rejection and Graft-versus-host disease. Common expamples of Type III HSN reaction: Ahus reaction Serum sickness Glomerulonephtiritis Rheumatoid ahritis TNFa is primarily responsible for Shwazman reaction, in which repeated injection of LPS (obtained from gram negative cell wall) into a solid tissue leads to hemorrhagic infarction.