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What is Resistance to drugs in Tuberculosis develops by - and explain in detail?
Ans. is 'd' i.e., Mutation o The most common mechanism of antitubercular drugs resistance is by mutation - INH --> Catalase - peroxidase gene (Kat G) or inh A gene. Rifampin --> rpo B gene PZA --> pnc A gene ETB --> emb B gene Streptomycin --> 16 S rRNA gene (rrs) or ribosomal protein S-12 gene (rpst).