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What is Which of the following is a topical vit. D analogue- and explain in detail?
Ans. is 'c' i.e., Calcipotriol VitDo It occurs mainly in two forms Vit D3 - Cholecalciferol - synthesized in skin under the influence of UV rays from 7-dehydrocholesterol.Vit D2 - Calciferol - present in irradiatiate food-yeast, fungi, bread,o Activation of Vit D takes place in following manner.o The final hydroxylation in the kidney by enzyme 1-a hydroxylase is the rate limiting step - enhanced by parathormone.o 1, 25 dihydroxy Vit D3 (calcitriol) is the active form of lit D3