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What is Which enzyme is active when Insulin: Glucagon ratio is low? and explain in detail?
In the fasting state, as the concentration of glucose in the poal blood coming from the small intestine falls, insulin secretion decreases, and skeletal muscle and adipose tissue take up less glucose. The increase in secretion of glucagon by a cells of the pancreas inhibits glycogen synthetase and activates glycogen phosphorylase in the liver. The resulting glucose-6-phosphate is hydrolyzed by glucose 6-phosphatase, and glucose is released into the bloodstream for use by the brain and erythrocytes. The above scenario indicates glucagon is more hence glucose-6-phosphatase becomes active.Ref: Harper&;s Biochemistry; 30th edition; Page no: 148