You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which drug can cause thyroid dysfunction is? and explain in detail?
ANSWER: (A) AmiodaroneREF: Goodman and Gillman s 11TH edition, page 1000, CURRENT Medical Diagnosis and treatment Chapter 26. Endocrine DisordersIndirect repeat in June 2010Amiodarone, because of its high iodine content, causes clinically significant Hypothyroidism inabout 8% of patients.ANTITHYROID COMPOUNDSProcess AffectedExamples of InhibitorsActive transport of iodide Complex anionsPerchlorate, Fluoborate, Pertechnetate, ThiocyanateIodination of thyroglobulin ThionamidesPropylthiouracil. Methimazole, Carbimazole Thiocyanate; iodide. Aniline derivatives; sulfonamidesCoupling reactionThionamides; sulfonamidesHormone releaseLithium salts, iodide, lodotyrosineIodothyronine deiodinationNitrotyrosinesPeripheral deiodinationThiouracil derivatives; Amiodarone Oral cholecystographic agentsHormone actionThyroxine analogs; AmiodaroneHormone excretion inactivationInducers of hepatic drug-metabolizing enzymes: phenobarbital, rifampin, carbamazepine, phenytoinBinding in gutCholestyramine