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What is A 24 year old male patient with h/o primary syphilis in the form of genital ulcer & mucocutaneous lesions, presents with features suggestive of neurosyphilis in the form of meningitis for which appropriate treatment was staed. What will you do for monitoring of treatment and explain in detail?
The nontreponemal cerebrospinal fluid (CSF) Venereal Disease Research Laboratory (VDRL) test is a mainstay for diagnosis of neurosyphilis. Although the estimated specificity of the test is high, the sensitivity is lower, which is a major limitation of the test Ref Harrison20th edition pg 2345