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What is Bronchospasm is initiated by? and explain in detail?
Ans. (c) Leukotrienes(Ref: Robbins 9th/pg 89)LTE4 cause intense vasoconstriction, bronchospasm (importantin asthma), and increased permeability of venules.C3a, C5a, and, to a lesser extent, C4a stimulate histamine release from mast cells and thereby increase vascular permeability and cause vasodilation. They are called anaphylatoxins