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What is Rivastigmine and Donepezil are drugs used predominantly in the management of which of the following conditions? and explain in detail?
In Alzheimer's disease the most common cause of dementia, there is a reduction in the activity of acetylcholine within the brain due to loss of cholinergic activity within the brain due to loss of cholinergic neurons in the nucleus basalis of Meyne . Both Rivastigmine and Donepezil are cholinesterase inhibitors used in the management of dementia. These drugs reduce the degeneration of acetylcholine by inhibiting the enzyme Acetyl cholinesterase.Ref: Alzheimer's Disease And Dementia in Down Syndrome And Intellectual Disabilities By Vee P. Prasher page 85.