You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Most common cause of abortion in first trimester is- and explain in detail?
Ans. is 'a' i.e., GeneticCauses of first trimester abortiono Genetic: Majority (50%) of the early miscarriages are due to the chromosomal abnormality of the conceptus.Autosomal trisomy is the commonest cytogenetic abnonnality. Trisomy 16 is the most common.o Endocrine and metabolic (10 - 15%)Luteal phase defect, deficient progesterone, thyroid abnormalities, diabetes mellitus. o Anatomical abnormalities (10 - 15%)Cervico - uterine factors (mostly related to second trimester abortion) - cervical incompetence and congenital malformation of the uterus.o Infections: (5%)Can cause early as well as late abortions.o Immunological disorders (5- 10 %)o Blood group incompatibilityo Premature rupture of membraneso Environmental: Cigarette smoking, alcoholo Unexplained.