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What is Which of the following drug causes QT prolongation? and explain in detail?
ANSWER: (C) FexofenadineREF: KDT 6th edition page 510, Harrison 18th edition page 1884 Table 233-5Drugs causing QT prolongation: (Potential to precipitate Torsades de pointes) Antiarrthymic: Amidarone, Disopyamide, Dofetilde, Dronedarone, Ibutilite, Sotalol, Quinidine, procainamide, Propafenone Antibiotics: Quinine, Gatifloxacin, sparfloxacin, Halofantrin, Voriconazole, artemisin Prokinetic drugs: Cisapride Antidepressants: Tricyclic antidepressants Antihistaminics: Terfenadine, astemiazole, ebastine, Fexofenadine Anesthetics: Bupivacine SSRIs (especially xvith Citalopram) Antipsychotics: Thioridazone, risperidone