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What is Major fibril protein in Primary Amyloidosis is? and explain in detail?
Ans. (a) AL(Ref: Robbins 9th/pg 257-260)AL protein is made of complete Ig light chains, amino- terminal fragments of light chains, or both.Most of the AL proteins are composed of l light chains or their fragments, but in some cases k chainsThe amyloid fibril protein of the AL type is produced from free Ig light chains secreted by a monoclonal population of plasma cells, like multiple myeloma.