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What is Central chemoreceptors are most sensitive to following changes in blood and explain in detail?
A rise in aerial PCO2 stimulates the RVLM Neurons located near the pial surface of the medulla in the rostral ventrolateral medulla (RVLM) are the central chemoreceptors Carbon dioxide can cross the blood-brain barrier easily and rapidly and causes changes Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No: 562 CO2diffuses readily into CSFand is immediately hydrated to form H2CO3.H2CO3 dissociates to form H+ and HCO3-. So blood pCO2 influences the pH of CSF