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What is Rifampin induces metabolism of which drug? and explain in detail?
Ans. is 'c' i.e., Nevirapine Rifampin Interactions Microsomal enzyme inducer - increases CYP 450 isoenzymes. It thus induces its own metabolism as well as metabolism of other drugs like warfarin, oral contraceptives, coicosteroids, sulfonylureas, HIV protease inhibitors, non nucleoside reverse transcriptase inhibitors (NNI), theophylline, metoprolol, fluconazole, ketoconazole, clarithromycin and phenytoin. Nevirapine is an NNI and thus its metabolism is induced by rifampin.