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What is Medication used in treatment of idiopathic central precocious puberty is: and explain in detail?
Ans. is c, i.e. GnRH analoguesRef: Novaks 15th/ed, p1017,1020; Textbook of Gynae shielabalakrishnan 1st/ed, p67-8If a female has developed both breast and axillary hair and she has cyclical vaginal bleeding, these findings favour central precocious puberty which is most commonly idiopathic.DOC for managing central precocious puberty is GnRH analogue -(Leuprolide)Principle - Continuous administration of GnRH agonist, downregulates and desensitizes GnRH receptor of pituitary, decreasing gonadotropin release leading to decreased estrogen production.Note: In these females GnRH should be withdrawn at the age of normal puberty.