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What is A 6-year-old boy presented with recurrent pyogenic abscess, runny nose, oral thrush & rash on perineal areas. Pus culture showed growth of Staphylococcus aureus. A test was performed whose finding is shown below. What is most common mode of inheritance of this disorder? and explain in detail?
Image represents Nitroblue tetrazolium test which points to the diagnosis of CGD. Chronic granulomatous disease Immunodeficiency disorder Due to mutation in PHOX gene Also known as bridges good syndrome Has both autosomal recessive & X-linked recessive inheritance but X-linked recessive is most common. Characterised by recurrent infections by catalase positive organisms like s. Aureus, candida etc. The simplest and most rapid test for CGD is the NBT (Nitroblue tetrazolium) test. Neutrophils from a small sample of peripheral blood are activated to produce superoxide which is detected by the NBT, which is conveed from a yellow water-soluble compound to a dark-blue insoluble formazan that can be clearly detected microscopically.