You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Atracurium is metabolized by - and explain in detail?
Ans. B. Hoffman degradationThe unique feature of atracurium is inactivation in plasma by spontaneous non enzymatic degradation (Hofmann elimination).Consequently its duration of action is not altered in patients with hepatic/renal insufficiency or hyperdynamic circulation ---> Hence, preferred muscle relaxant for such patients as well as for neonates and the elderly.Atracuum is metabolised to laudanosine that is responsible for seizures.Cause histamine release > Hypotension, bronchoconstriction & flushing.