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What is During intrauterine life, hepatic stage of erythropoiesis starts at? and explain in detail?
Ans. C 12th weekRef: Diagnostic Pediatric Hematopathology By Maria A. Proytcheva 2011 ed. pg. 6Fetal liver is the major site for erythropoeisis between 11 and 24 weeks of gestation. Primitive hematopoiesisDefinitive hematopoiesisHematopoietic siteYolk sac and vascular endotheliumFetal liver and fetal bone narrow Hematopoietic nichesType of HematopoiesisMostly erythroidMultileneage HematopoiesisRBCCharacteristicsRemain Nucleated during their entire lifespanEnucleated RBCsCell SizeMacrocyticMCV decreases with gestational age Primitive hematopoiesisDefinitive hematopoiesisSensitivity to EPOIncreasedLower sensitivityLifespanShortIncreases with gestationHemoglobin typeEmbryonic: Gower 1, Gower 2 and PortlandFetal Hb (a2 y2 ) and adult Hb (a2 b2 )