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What is Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase? and explain in detail?
Ans: B. Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm(Ref Harper 30/e p178)Glucose-6-phosphate:Formed in cytoplasm of hepatocytes.Glucose-6-phosphatase:Present in lumen of smooth endoplasmic reticulum of cell.Reaction does not take place until gluconeogenesis is ored.Glucose-6-phosphatase catalyzes hydrolysis of glucose-6-phosphate in liver - Expos glucose a increases blood glucose concentration