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What is Sustained Response to antiviral therapy (IFN + Ribavarin) in hepatitis C is indicated by and explain in detail?
Answer is D (Female sex): Female sex is a ourable feature, associated with sustained responsiveness to antiviral therapy Male sex is associated with reduced responsiveness. Reduced Responsiveness Genotype 1 High levels of HCV RNA Adranced fibrosis (ciorrhosis, bridging fibrosis) Long duration disease Age > 40 years I mmunosupression African American Obesity Hepatic steatosis Reduced adherence Male sex (Handbook of Gastroenterology) Sustained Responsiveness Genotype 2 and 3 Low levels of HCV RNA Minimal fibrosis Sho duration disease Age < 40 years Immunocompetance Others Absence of obesity Absence of Hepatic steatosis Increased Adherence Female sex (Handbook of Gastroenterology)