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What is The rate-limiting step for nor-epinephrine synthesis is: and explain in detail?
Ref: KD Tripathi Pharmacology 7th edition(page no;125) Catecholamines like epinephrine, norepinephrine, dopamine are synthesized from the amino acid phenylalanine. Tyrosine hydroxylase is the rate-limiting enzyme and its inhibition by alpha-methyl-p-tyrosine results in depletion of norepinephrine Tyrosine hydroxylase helps in Conversion of tyrosine to DOPA