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What is The mechanism of action of haloperidol is the blockage of and explain in detail?
(C) Dopamine receptor # Haloperidol, Trifluperidol, Droperidol, Penfluridol are Butyrophenones and act as antipsychotic drugs.> All antipsychotic (except clozapine like) have potent dopamine D2 receptor blocking action.> So, it is clear that Haloperidol act by blocking dopamine receptor.> Uses of haloperidol are in acute schizophrenia, Huntington's disease.> Clozapine has significant 5-HT2 and at blocking action.> Dopaminergic blockade in basal ganglia cause extrapyramidal sign while that in CTZ is responsible for antiemel action.