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What is Creatine is synthesized from which of the following? and explain in detail?
Creatine is synthesized from glycine, arginine, and methionine. clinical impoance: 1. Creatine kinase has 3 isoenzymes, which are elevated in the following diseases: CK-MM: Muscular dystrophy, acute kidney injury, autoimmune myositis, hypothyroidism, malignant hypehermia, and drug-induced myopathy CK-BB: Stroke, brain injury, and meningitis CK-MB: Myocardial infarction, and myocarditis 2. Normally, creatinine is rapidly removed from the blood and excreted in the urine. Hence, creatinine clearance is a sensitive indicator of kidney function. Reference: Harpers illustrated biochemistry 30th edition