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What is In antibiotic associated colitis, organism involved is - and explain in detail?
Ans. is 'a' i.e., Clostridium difficile Antibiotic - associated (or clostridium difficile associated) colitis o It is an example of superinfection. o It is caused by alteration of normal bowel flora, which allows multiplication of clostridium difficle which releases several toxins that damage the mucosa of the bowel and promote excretion of fluid. o It takes the form of an acute, nonspecific colitis, i.e. pseudomembranous colitis. o Almost any antimicrobial may initiate this condition, but the drugs most commonly repoed today are injectable cephalosporins and amoxi/ampicillin -- Laurence 9th/e 212 o Clindamycin, not commonly used in routine practice today, had an even greater propensity. o Metronidazole is the DOC for pseudomembranous colitis and vancomycin is an alternative.