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What is Which of the following is beneficial in NSAID induced gastric ulcer? and explain in detail?
Prostaglandin analogues exe a cyto-protective effect on the gastric mucosa which prefers them to be employed in the treatment of NSAID induced gastric ulcer. Though both PGE1 analogues (Misoprostol and Risoprostol) and PGE2 analogues (Enoprostol) have shown proven effects on gastric ulcer, only misoprostol is a FDA approved orally active and stable analogue of PGE1 to be used in the treatment of NSAID induced gastric ulcer. Ref: K D Tripathi Textbook of Pharmacology, 5th Edition, Pages 88, 163-64, 593-94; Prostanoids: Pharmacological, Physiological, and Clinical Relevance By Philip Keith Moore, Pages 68, 220