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What is Biconcave shape of RBC is due to binding of spectrin to- and explain in detail?
Ans. is 'a' i.e., Ankyrin * RBCs biconcave shape is due to membrane cytoskeleton.* RBC membrane cytoskeleton contains a filamentous meshwork of proteins that form a membrane cytoskeleton along the entire cytoplasmic surface of membrane. The most abundant and most important protein in this membrane cytoskeleton is Spectrin, a long flexible heterodimers. At ends it binds with junctional complex composed of F-actin tropomyocin, adducin and protein-4.1.* This cytoskeletal network is tethered to cell membrane at two sites-i) Mediated by ankyrin that links spectrin to Band-3.ii) Mediated by protein-4.1 that links junctional complex to Glycophorin C.