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What is Which of the following drugs can cause lipodystrophy? and explain in detail?
Ans. (C) Saquinavir(Ref: Goodman & Gilman 11th/e p1301)All protease inhibitors are associated with HIV-lipodystrophy. Saquinavir is a protease inhibitor.All NRTIs are associated with lactic acidosis. Stavudine can also cause lipoatrophy (maximum among NRTIs).Insulin can also result in lipodystrophy.