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What is False about signal recognition paicle ? and explain in detail?
Binding of a signal sequence to SRP temporarily blocks the translation SIGNAL RECOGNITION: Signal recognition sequence originates from ribosomes & bind to SRP. This causes temporary arrest in elongation of translation. SRP guides the protein to SRP-R. SRP-ribosome -nascent protein binds to SRP-R then SRP guides the protein to SRP-R. The SRP is released from SRP-R. The ribosome binds to sec 61 complex ( translocon ), then the signal peptide gets inseed into the channel in translocon and translation resumes. Interaction of SRP - SRP-R occurs GTP hydrolysis Reference: Harper; 30th edition