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What is Which of the following drugs produce significant nephrotoxicity? and explain in detail?
Carboplatin It is a less reactive second generation platinum compound that is better tolerated and has a toxicity profile different from cisplatin. Nephrotoxicity, ototoxicity and neurotoxicity are low. Nausea and vomiting is milder and is delayed: only infrequently limits the dose. The dose-limiting toxicity is thrombocytopenia and less often leucopenia. Because of less plasma protein binding, it is rapidly eliminated by the kidney (half life 4-6 hr). It is primarily indicated in ovarian carcinoma of epithelial origin, and has shown promise in squamous carcinoma of head and neck, small cell lung cancer and seminoma. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:828