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What is The HLA class III region genes are important elements in and explain in detail?
*HLA class III region contains genes for early complement components C2 and C4 of classical pathway.
*Deficiency of these early components of the classical pathway viz C1, C2 and C4 is associated with autoimmune diseases like SLE and other collagen vascular diseases.
• These genes are thus, important in regulating susceptibility to autoimmune disease
• Class III genes do not participate in MHC restriction or graft rejection components.