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What is The drug which reduces the size of myoma include- and explain in detail?
GnRH analogues used for 6months reduces the tumour size by 50-80%. This treatment in premenopausal women, young women and infeility caused by cornual fibroid eliminates the need for surgery. RU 486(Mifepristone) 10-25mg daily for 3months causes amenorrhoea and shrinkage of tumour by 50%. Danazol 400-800mg daily for 3-6months reduces the size of the tumour. However side effects includes hirsutism as well as costly. Reference: Textbook of shaw,15th edition,page 359