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What is Hb is a good buffer because of: and explain in detail?
Harper mentions …‘Hemoglobin also functions in CO2 and proton transport from tissues to lungs. Release of O2 from oxy-Hb at the tissues is accompanied by uptake of protons, due to lowering of the pKa of histidine residues.’

Decarboxylation of histidine to histamine is catalyzed by a broad-specificity of aromatic L-amino acid decarboxylase.
Histidine compounds present in the human body include ergothioneine, carnosine, and dietary anserine.