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What is DPP-4 inhibitor that can be used in renal failure is: and explain in detail?
DPP-4 inhibitors: Competitive and selective inhibition of DPP-4 which potentiates the action of GLP- 1 and GIP, boosts postprandial insulin release, decreases glucagon secretion and lowers meal-time as well as fasting blood glucose in type 2 diabetics. Eg.: Sitagliptin, Vildagliptin, Saxagliptin, Alogliptin, Linagliptin. Only Linagliptin is safe in renal failure. MC S/E of Gliptins: Nasopharyngitis.