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What is Drug of choice for CML and explain in detail?
Ans. (a) Imitanib mesylate (Doc for CML & GIST - Imatinib Mesylate)Ref. KD Tripathi 6th Ed. / 828 & 832IMATINIB* It inhibits the tyrosine protein kinases in chronic myeloid leukaemia (CML) cells and and c-kit receptor found in gastrointestinal stromal tumour (GIST).* Adverse effects are fluid retention, edema, vomiting, abdominal pain, myalgia and liver damageDrugs of choice for some commonly asked malignanciesMalignancyFirst line drugsChronic Lymphatic leukaemiaFludarabineChronic Myeloid leukaemiaImatinibHairy cell leukemiaCLADRIBINEMultiple myelomaMelphalanChoriocarcinomaMethotrexateProstate carcinomaBicalutamide/Flutamide