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What is Knife edge pattern of neuronal atrophy is associated with which of the degenerative disease of the coex and explain in detail?
Pick's disease is characterized by a progressive frontotemporal lobar atrophy, gliosis, severe neuronal loss, aB-crystallin-immunoreactive ballooned neurons, and the presence of argyrophilic (but Gallyas-negative) neuronal inclusions, the Pick bodies, in the cerebral coex and some subcoical structures. The "knife-edge" coical atrophy is frequently asymmetric and predominates in the frontal and temporopolar regions Refer robbins 9/e 840