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What is Which of the following enzymes are responsible for generating 'oxygen burst' within neutrophils for killing intracellular bacteria? and explain in detail?
The final step in the microbial killing is due to reactive oxygen species called respiratory burst The generation of the oxygen metabolites is due to rapid activation of a leukocyte NADPH oxidase, called the phagocyte oxidase, which oxidizes NADPH and, in the process, conves oxygen to superoxide ion (O2 * ) The reactive oxygen species thus produced are toxic to bacteria and help the phagocyte kill them once they are ingested. ref robbins basic pathology 9th ed page 38