You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Graft vs Host reaction can be reduced by? and explain in detail?
Ans. (a) Irradiation(Ref: Wintrobes 13th/704-705)Irradiation with a dose of 2,500 cGy at the center of the irradiation field, with a minimum dose of 1,500 cGy at any point in the field inhibits proliferation of donor lymphocytes but has no significant adverse effect on red cell, platelet, or granulocyte function.It should be noted that though the other options are also effectice in reducing the leukocytes but they do not completely deplete the lymphocytes and so can cause GVHD.