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What is Which of the following antiretroviral therapy is contraindicated in pregnancy and explain in detail?
(Efavirenz) (1172- CMDT- 08) (300 - 301- Dutta 6th)EFAVIRENZ - Advantage - once daily in single doseSide effects - Neurologic, lack of concentration, delusion and mania* Efavirenz should be avoided in women who wish to concieve or already pregnant due to teratogenicity* Vertical transmission to the neonates is about 14-25%** and majority (40- 80%) occurs during the labours* The median time from infection to AIDS is about 10 years* Triple chemotherapy is preferred as a first line defence and to be started any time between 14 and 34 weeks and then continued throughout pregnancy, labour and postpartum period* Minor risk associated with breast feeding* **Barrier methods of contraceptions (Condome or female condome) is effective in preventing transmission of the virus* Most Ascian countries the infection rate is less than 0.5%