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What is Which of the following best describes a pharmacologic propey of amiodarone? and explain in detail?
Amiodarone Mech of action:- It is iodine containing highly lipophilic long-acting antiarrhythmic drug exes multiple actions: * Prolongs APD and Q-T interval attributable to block of myocardial delayed rectifier K+ channels. This also appears to reduce non-uniformity of refractoriness among different fibres. * Preferentially blocks inactivated Na+ channels (like lidocaine) with relatively rapid rate of channel recovery: more effective in depressing conduction in cells that are paially depolarized or have longer APD. * Paially inhibits myocardial Ca2+ channels, has noncompetitive b adrenergic blocking propey and alters thyroid function. Ref:- kd tripathi; pg num:-533