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What is High plasma protein binding of a drug results in and explain in detail?
* Most drugs bind to plasma proteins in a reversible fashion without translating into a pharmacological response. (Plasma proteins are hence called Silent Receptors) * Acidic drugs bind to Albumin, Basic drugs to alpha1 acid- glycoprotein. * Binding of the drug to plasma protein affects the pharmacokinetic handling of drug by the body. Ref:- HL & KK Sharma's Principles of Pharmacology 3rd Ed; Pg Num:- 48