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What is Enzyme involved in cleavage of glycine in liver mitochondria is and explain in detail?
Starvation. All the three amino acids undergo similar sequence of reactions. These are summarized in Table 16.2. In this pathway, the second enzyme is a branched chain alpha-keto acid dehydrogenase. It is a complex of decarboxylase, transacylase and dihydrolipoyl dehydrogenase. So, this resembles pyruvate dehydrogenase Only liver mitochondria contain glutamate dehydrogenase (GDH) which deaminates glutamate to alpha-ketoglutarate plus ammonia. So, all amino acids are first transaminated to glutamate, which is then finally deaminated (transamination)Ref: DM Vasudevan, Page no: 200