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What is All are TRUE about glutathione, EXCEPT: and explain in detail?
Glutathione is a tripeptide. It is synthesized from -glutamic acid, cysteine, and glycine. Glutathione exists in the cell as oxidized (GSSG) or reduced (GSH) forms, and the ratio of GSH:GSSG is critical in maintaining a cellular environment in the reduced state. In addition to affecting xenobiotic conjugation with GSH, a severe reduction in GSH content can predispose cells to oxidative damage, a state that has been linked to a number of human health issues. Glutathione prevents oxidation of hemoglobin to methemoglobin. Ref: Gonzalez F.J., Coughtrie M., Tukey R.H. (2011). Chapter 6. Drug Metabolism. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.