You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Major contribution to cachexia with advanced cancer- and explain in detail?
Cachexia is not caused bu nutritional demands of the tumor. It is suspected that TNF produced by macrophages in response to tumor cells or by the tumor cells them self mediate cachexia. TNF mobilize fat from tissue stores and suppress appetite. ROBBINS