You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is True about anticonvulsants: (PGI Nov 2009) and explain in detail?
Ans: C (Monotherapy is recommended) Phenytoin, Carbamazepine. Valproate and Phenoharhital all have been associated with teratogenic effects^Very recent reports suggest a higher than expected incidence of cleft lip with the use of lamotrigine- during pregnancy.Preganant women shoul be maintained on effective drug therapy preferably on monotherapy" at the lowest effective dose, especially during the first trimester.Patients should also take folateQ (1-4 mg/d) to prevent neural tube defects.The risk of teratogenicity increases with the number of medications'9 used (e.g. 10% risk of malformations with three drugs).Vit. K is given during last month of pregnancy: to prevent coagulopathy & intracerebral haemorrhage in newborn (common with antiseizure drugs that induce CYPs)