You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is BCR ABL gene mutation is seen in? and explain in detail?
CML is distinguished from other myeloproliferative disorders by the presence of a chimeric BCR-ABL gene derived from the poions of BCR gene on chromosome 22 and ABL gene on chromosome 9.It directs the synthesis of a constitutively active BCR-ABL tyrosine kinase. Reference; Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 616