You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Streptococcal toxic shock syndrome is due to liberation of and explain in detail?
Pyrogenic exotoxin ( erythrogenic, Dick, scarlatinal toxin): the toxin was named erythrogenic because it's intradermal injection into susceptible individuals produced an erythematous reaction. The primary effect of the toxin is induction of fever and so it was renamed streptococcal pyrogenic exotoxin. 3 types of SPE have been identified: A, B, and C, types A and C are coded by bacteriophage genes while type B gene is chromosomal. SPE are superantigens, T cell mitogens that induce a massive release of inflammatory cytokines, causing fever, shock and tissue damage. Soft tissue infections with some eM types 0f S.pyogenes (1, 3, 12, 28) may sometimes cause a toxic shock syndrome resembling staphylococcal TSS. Reference: Textbook of Microbiology; Anathanarayan and paniker's; 10th edition; Page no: 214, 215