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What is Drugs used for ovulation induction are: and explain in detail?
Ovulation induction is done with clomiphene citrate with a dose of 50mg/day to maximum 250mg daily,if the ovulation is not induced by the lower dose. The actual staing day of its administaion in the follicular phase varies between day 2 and day5. Therapy is given for 5days. Mechanism of action: Clomiphene citrate is anti-estrogenic as well as weakly estrogenic. It blocks the estrogen receptors in the hypothalamus. This results in increased GnRH pulse amplitude causing increased gonadotropin secretion from the pituitary. Reference: DC Dutta's textbook of Gynaecology-7th edition-page no 199.