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What is All of the following drugs can be given to a mother with lupus after 35th week of gestation, except: and explain in detail?
Methotrexate is a folic acid antagonist and it is contraindicated in pregnancy. It is highly teratogenic. The metabolites are active in the cells and tissues even after several weeks to months following discontinuation. So it is usually recommended to stop 3-6 months prior to the planned conception. Ref: Prescribing in Pregnancy edited by Peter C. Rubin, Margaret Ramsey, Pages 105, 103; Oxford textbook of medicine, Volume 1 By D. A. Warrell, Timothy M. Cox, John D. Fih, Page 752; Drugs During Pregnancy and Lactation By Christof Schaefer, Pages 166; Harrison textbook of medicine 17th edition, Pages 1291, 1272, 2082.