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What is Phosphodiesterase inhibitor used for erectile dysfunction and explain in detail?
Ref: KD Tripathi, 7th ed. pg. 303* Sildenafil is an orally active drug for treatment of ED. Sildenafil acts by selectively inhibiting PDE-5, causing increase in cGMP and enhancing Nitric Oxide action on corpus cavernosum.* Amrinone and Milrinone are PDE-3 inhibitor and are also called inodilators. They are used in CHF.* Tamoxifen is a selective estrogen receptor modulator, used in breast cancer.