You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Select the false statement among the following? and explain in detail?
* Lipid soluble drugs (nonpolar) have high volumes of distribution than drugs which are more polar* Volume of distribution may be increased in renal failure & hepatic failure due to fluid retention, altered body fluid. However high plasma protein binding reduces the Vd. Loading dose = volume of distribution x target plasma concentration Maintenance dose = clearance x target plasma concentration T 1/2 is constant in first order kinetics T 1/2 is directly propoional to plasma concentration in zero order kinetics Clearance is indirectly propoional to plasma concentration