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What is The drug NOT used in prostatic carcinoma : and explain in detail?
Ans. is 'c' Testosterone Medical management of Testicular CaThe aim is to reduce the testosterone level or its effect producing chemical castrationThe drugs areGnRH analogue* (leuprolide acetate*)Initially it produces a rise in LH and FSH which increases testosterone level initially but after sometimes due to down regulation of receptors on pituitary LH & FSH decrease there by decreasing TestosteroneAntiandrogen (Flutamide)*Estrogen (Diethylstilbestrol)*Finasteride*prevents the conversion of testosterone to its active component. It is a 5 alpha reductase inhibitor*Second line t/tKetoconazole*Aminoglutethimide*