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What is Mechanism of action of theophylline in Bronchial asthma include all of the following Except ? and explain in detail?
Ans. is 'd' i.e., Beta-2 receptor stimulation Proposed mechanisms of action of theophylline Phosphodiesterase inhibition (Non selective) Adenosine receptor antagonism (A1, A2) Increased histone Deacetylase activity (|red efficacy of coicosteroids) Inhibition of intracellular calcium release Stimulation of catecholamine release Inhibition of NF - alpha Beta translocation into the nucleus (nuclear translocation) Mediator inhibition (Prostaglandins, TNF alpha)