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What is Blindness seen in methanol poisoning is due to? and explain in detail?
Ans. is 'a' i.e., Formic acid o Formic acid is the primary agent responsible for the toxic effects and occular complications.o Methanol is metabolized to formaldehyde (by alcohol dehydrogenase) and formic acid (by acetaldehyde dehydrogenase).o It is the accumulation of formic acid which causes toxic effects in methanol poisoning. Accumulation of formic acid results in lactic acidosis/high anion gap metabolic acidosis with low plasma bicarbonates, blindness due to retinal damage, papilledema and optic atrophy.