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What is Metoclopromide - and explain in detail?
Ans. is 'b' i.e., Increases lower esophageal sphinctor pressure Effects of metoclopramide on GIT Metoclopramide has 5-HT4 agonistic and D2 antagonistic activity in GIT. o These two actions result in enhanced cholinergic smooth muscle stimulation. o Metoclopramide has prominent effect on upper GIT i) Increases gastric peristalsis ii) Relaxes pylorus and first pa of duodenum iii) Tone of lower esophageal sphinctor is increased o Metoclopramide has no or minimal effect on lower GIT --> increases intestinal motility to some extent, but has no action on colonic motility.