You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is E cadherin gene deficiency is seen in: and explain in detail?
Cadherin is derived from the “calcium-dependent adherence protein.” It participates in interactions between cells of the same type. The linkage of cadherins with the cytoskeleton occurs through the catenins. 
The cell-to-cell interactions mediated by cadherin and catenins play a major role in regulating cell motility, proliferation, and diﬀerentiation and account for the inhibition of cell proliferation that occurs when cultured normal cells contact each other (“contact inhibition”).
Reduced function of E-cadherin is associated with certain types of breast and gastric cancer. Mutation and altered expression of the Wnt/β-catenin pathway are implicated in gastrointestinal and liver cancer development.