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What is A 30 year old lady presents to the outpatient depament with an Erythematous butterfly rash on her checks. Which of the following antibodies should be assayed initially for her suspected condition - and explain in detail?
Anti-dsDNA antibodies are a group of anti-nuclear antibodies (ANA) and their target antigen is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories. They are highly diagnostic of systemic lupus erythematosus (SLE) and are implicated in the pathogenesis of lupus nephritis.