You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is involved in tumor metastasis cascade:- and explain in detail?
Ans. is 'b' i.e. E. cadherin For the tumor cells to metastasize they must-1st - detach from each other.Next - traverse the extracellular matrix (i. e. the basement membrane and interstitial connective tissue).Normally the cells are neatly glued to each other and their surrounding by a variety of adhesion molecules.Of these the E-Cadherin is most important. Any abnormality of E-cadherin molecule or down-regulation of its expression would lead to detachment of the cells from the primary tumor and move out for metastasis.