You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Non pitting edema is seen in ? and explain in detail?
A consequence of prolonged hypothyroidism is increased dermal infiltration of glycosaminoglycans (mucopolysaccharides, hyaluronic acid and chondroitin sulphate) which traps water, giving rise to skin thickening without pitting (myxedema). Typical features include a puffy face with edematous eyelids and nonpitting pretibial edema. Reference : page 2291 Harrison's Principles of Internal Medicine 19th edition and page 743 Davidson's Principles and practice of Medicine 22nd edition