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What is Which of the following viral markers signifies the ongoing viral replication in the case of Hepatitis-B infection? and explain in detail?
HBeAg appearance- high levels of virus replication and reflects the presence of circulating intact virions and detectable HBV DNA. Patients with precore mutations cannot synthesize HBeAg In self-limited HBV infections, HBeAg becomes undetectable sholy after peak elevations in aminotransferase activity, before the disappearance of HBsAg, and anti-HBe then becomes detectable, coinciding with a period of relatively lower infectivity.