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What is Muscle relaxant safe in renal failure patient is:- and explain in detail?
Atracurium and cis-atracurium undergo Hoffmann's elimination (spontaneous non-enzymatic molecular rearrangement) and are the agents of choice for patients with hepatic or renal insufficiency. Atracurium is metabolized to laudanosine that is responsible for seizures. Cis-atracurium is relatively safe in this regard. Cis-atracurium release much less histamine as compared to atracurium.