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What is In Alzheimer’s disease, plaque is made up of: and explain in detail?
(Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 1313-1317)
Morphology of Alzheimer's disease

Cortical atrophy especially in frontal, temporal and parietallobes.
Compensatory ventricular enlargement due to loss ofparenchyma and reduced brain volume - (hydrocephalus exvacuo).
Structures involved early - medial temporal lobe, including hippocampus entorhinal cortex and amygdala.
Progressive severe neuronal loss and reactive gliosis