You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is True about proton-pump inhibitor omeprazole is and explain in detail?
CYP 2C19 is the principal enzyme that metabolizes omeprazole to an inactive metabolite. The efficacy of drug-influenced by the CYP 2C19 genotype. 


 Reduced CYP2C19 enzyme activity (poor metabolizers) may lead to higher exposure to the drug and improve outcome at standard doses.
 In contrast, increased CYP2C19 activity (ultrarapid metabolizers) may have an insufficient response to treatment as the drug is inactivated faster.


 Omeprazole is highly plasma protein bound drug,
 It has oral bioavailability around 50%