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What is Negri bodies, which are pathognomonic of Rabies, are commonly found in which of the following cells? and explain in detail?
Rabies Severe encephalitis transmitted to humans by the bite of a rabid animal, usually a dog or various wild mammals. Microscopically, there is widespread neuronal degeneration and an inflammatory reaction that is most severe in the brainstem. Negri bodies, the pathognomonic microscopic finding, are cytoplasmic, round to oval, eosinophilic inclusions found in pyramidal neurons of the hippocampus and Purkinje cells of the cerebellum, sites usually devoid of inflammation. Rabies virus can be detected within Negri bodies by ultrastructural and immunohistochemical methods.