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What is All are proved to delay or prevent diabetes in those with impaired glucose tolerance, except and explain in detail?
Intensive changes in lifestyle (diet and exercise for 30 min/d five times/week) in individuals with IGT prevented or delayed the development of type 2 DM by 58% compared to placebo. In the same study, metformin prevented or delayed diabetes by 31% compared to placebo.A number of agents, including a-glucosidase inhibitors, metformin, thiazolidinediones, GLP-1 receptor pathway modifiers, and orlistat, prevent or delay type 2 DM but are not approved for this purpose. Pharmacologic therapy for individuals with prediabetes is currently controversial because its cost-effectiveness and safety profile are not known. Ref: Harrison 19e pg: 2406