You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Mesna is used in - and explain in detail?
Ans. is 'a' i.e,, Hemorrhagic cystitiso Cyclophosphamide, an anticancer drug is the drug of choice for Wegener's granulomatosis.o Cyclophosphamide is a prodrug and is activated by hepatic biotransformation to aldophosphamide. One of its degradation products is acrolein that is responsible for hemorrhagic cystitis (its characteristic adverse effect). This adverse effect can be decreased by vigorous hydration and by the use of mercapto ethane sulfonic acid (mesna).o Cyclophosphamide may also result in cardiac dysfunction, pulmonary toxicity' and syndrome of inappropriate ADH secretion. Related drug ifosfamide is also implicated in causing hemorrhagic cystitis. Cyclophosphamide is a powerful vesicant.