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What is Anti -DNA antibodies are specific for: and explain in detail?
Ans. D: SLE Anti-DNA antibodies are highly specific (95%) but only moderately sensitive (30%) for SLE Anti-topoisomerase 1 (also termed Scl-70) antibodies are specific for diffuse systemic sclerosis, whereas anti-centromere antibodies are more specific for limited systemic sclerosis Anti-dsDNA It is present in 50-70% of patients with SLE. Circulating DNA/anti-DNA immune complexes are considered to play a pa in the pathogenesis of SLE. The presence of anti-dsDNA is one of the diagnostic criteria for SLE. IgG antibodies to dsDNA are considered clinically most useful for the diagnosis and management of SLE. Antibodies to single stranded DNA (ssDNA) and IgM antibodies to dsDNA are found in a number of other connective diseases, liver diseases, as well as in some normal individuals. Accurate detection of anti-dsDNA is impoant in the diagnosis and management of SLE.