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What is Major aim of phase 1 clinical trials is:- and explain in detail?
Phase 1 clinical trial : It is first phase in humans. It is conducted mainly on healthy volunteers. In drugs with serious adverse effects and where alternative treatment is not available, phase 1 can be conducted on patients also. Major aim is to know the maximum tolerable dose (MTD). The aim of phase 1 trials should be marked as MTD > Dose > Pharmacokinetics > Safety