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What is Investigation of choice for retinoblastoma is and explain in detail?
Retinoblastoma is malignant congenital intraocular tumour arising from primitive photoreceptor cells of the retina (included in primitive neuroectodermal tumour group)Two types -Heritable and non-heritableTrilateral retinoblastoma (rare variant)= bilateral retinoblastomas + neuroectodermal pineal tumor (pineoblastoma)Quadrilateral retinoblastoma= trilateral retinoblastoma + 4th focus in suprasellar cisternMRI is the modality of choice for pre-treatment staging on retinoblastomaPrognosis: Spontaneous regression in 1%Calcification is a ourable prognostic signContrast enhancement is a poor prognostic sign(Ref: Radiology Review ManualBy Wolfgang Dahne 6thEtd, 351)