You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is All of the following are advantages of transdermal drug delivery systems EXCEPT: and explain in detail?
Transdermal route is employed for highly lipid soluble drugs that can traverse intact skin. The size of the pores in transdermal patch is adjusted to produce a uniform and smooth absorption of the drug. This will thus, produce a delayed and smaller peak in the plasma concentration. As the drug is going directly in the bloodstream, first pass metabolism is avoided. Eg : Transdermal patch- Rotigotine is used in Parkinson disease