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What is Which of the following is the cause of break of glomerular basement membrane sometimes and sub epithelial deposits in electron microscopy?- and explain in detail?
Disease Pathogenesis Light Microscopy Fluorescence microscopy Electron microscopy Minimal-change disease podocyte injury Normal Negative Effacement of foot processes; no deposits Focal segmental glomerulosclerosis Unknown: reaction to the loss of renal mass. Focal and segmental sclerosis and hyalinosis Usually negative; IgM and C3 may be present in areas of scarring Effacement of foot processes; epithelial denudation Membranous glomerulonephritis Insitu immune complex formation; PLA2R antigen in most cases of primary disease Diffuse capillary wall thickening and subepithelial "spike" formation Granular IgG and C3 along GBM Subepithelial deposits Membranoproliferative GN immune complex Membranoproliferative pattern; GBM splitting Granular IgG, C3, C1q, and C4 along GBM and mesangium subendothelial deposits Ref: ROBBINS BASIC PATHOLOGY 10th ed Pg no: 556