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What is Which of the following antibodies is most frequently seen in Antiphospholipid Syndrome ? - and explain in detail?
Antiphospholipid antibody syndrome has clinical manifestations including recurrent thrombosis, repeated miscarriages, cardiac valve vegetations and thrombocytopenia. Suspected Ab target include Beta 2 Glycoprotein 1, a plasma protein that associates with the surfaces of endothelial cells and trophoblasts. Anti nuclear antibody and beta 2microglobulin Ab seen in SLE. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition -9;volume 1.page no. 124