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What is Serum alkaline phosphate is normal in: September 2009 and explain in detail?
Ans. C: Multiple Myeloma I. Increased alkaline phosphatase levels: Increased calcium deposition in bone Hyperparathryroidism Pagets disease Osteomalacia / rickets: in both cases there is failure of mineralization; Caffey's syndrome (infantile coical hyperostosis) Osteoblastic bone tumors (metastatic or osteogenic sarcoma) alkaline phosphatase level is high in about 1/2 of patients with osteosarcoma & in smaller fraction of those with another type of primary malignant bone tumor; Pregnancy Childhood Liver disease such as biliary obstruction Total Parenteral Nutrition (TPN) II. Decreased alkaline phosphatase levels: Malnutrition Excess Vit D ingestion; Hypophosphatasia