You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Gold standard diagnostic method for guiding antibiotic therapy in a case of osteomyelitis is ____: and explain in detail?
Ans. B. Bone biopsyBone biopsy is the gold standard method for guiding antibiotic therapy in case of osteomyelitis.Wound swab is not a definitive method to confirm the origin of bacterial infection because the organism need not necessarily contaminate the wound. Similarly, a negative sinus tract culture also does not rule out the possibility of an infection on the inside as it is not essential for the organism to travel up to the surface.A blood culture may be used to guide antibiotic therapy for hematologically acquired osteomyelitis but the gold standard investigation always remains a bone biopsy.