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What is The granuloma is characterized by and explain in detail?
Granulomatous inflammation is a distinctive pattern of chronic inflammation characterized by aggregates of activated macrophages with scattered lymphocytes granuloma:-is an aggregation of macrophages surrounded by a collar of mononuclear cells principally lymphocytes Macrophages may get activated to form epithelioid cells Some of the cells may fuse together to form a bigger cell called a giant cell Older granulomas may have a rim of fibroblasts and connective tissue Common conditions resulting in granuloma formation with impoant features Tuberculosis Sarcoidosis (Non-caseating granuloma) Brucellosis Cat scratch disease (Stellate shaped or round granuloma) Syphilis (Gumma) Leprosy Inflammatory bowel disease ref pathology robbins 9th ed page 56