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What is Which of the following is true about alpha 1 antitrypsin and explain in detail?
* alpha 1 antitrypsin deficiency is an Autosomal recessive disorder * It is synthesised in the liver * Deficiecy of alpha 1 antitrypsin can cause panacinar emphysema and can affect the liver. * Normal (wild) genotype of PiMM * alpha 1 antitrypsin deficiency can cause globular cytoplasmic inclusions in hepatocytes * These inclusions are PAS positive and diastase resistant Ref:- Robbins Basic Pathology 10th Edition; Pg num:- 658,659