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What is A 34 year old man with a long history of asthma is referred to pulmonologist. The physician decides to prescribe zileuton. The mechanism of action of this drug is to: and explain in detail?
Ans. (b) Inhibits 5 -lipoxygenase* Leukotrienes are biochemical mediators that contribute to asthma symptoms# Contracting airway smooth muscle# Increasing vascular permeability and mucus secretion# Attracting and activating airway inflammatory cells* Zileuton is a 5-lipoxygenase inhibitor that decreases leukotriene production, and zafirlukast and montelukast are cysteinyl leukotriene receptor antagonists.* They are useful to prevent asthma attacks and cause modest improvements in lung function. They lessen the need for b2 - agonist rescue therapy.