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What is Peripheral vasospasm is adverse effect of which drug? and explain in detail?
Bromocriptine and pergolide are ergot derivatives and dopamine agonists These are known to cause vasoconstriction and thus gangrene S/E of Pergolide : Valvular hea disease Pramipexole and ropinirole are also dopamine agonists but these are non-ergot derivatives. These do not cause gangrene and are longer acting. S/E of Ropinirole : Nausea, dizziness, hallucinations,postural hypotension.