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What is Which anti TB drug is avoided in HIV patient ? and explain in detail?
Ans. is 'b i.e., Rifampicin All HIV-infected TB patients are candidates for A, and the optimal timing for its initiation is as soon as possible and within the first 8 weeks of anti-TB therapy. Rifampin, a potent inducer of enzymes of the cytochrome P450 system, lowers serum levels of many HIV protease inhibitors and some non- nucleoside reverse transcriptase inhibitors-essential drugs used in A. In such cases, rifabutin, which has much less enzyme- inducing activity, has been recommended in place of rifampin. However, dosage adjustment for rifabutin and/or the antiret- roviral drugs may be necessary.