You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Inhalational halogenated anesthetics may cause malignant hyperthermia in(372- KDT 6th) (Lippincott's 3rd pharmacology) and explain in detail?
D. i.e. (Genetic defect in calcium channel at sarcoplasmic reticulum of the skeletal muscle) (372-KDT 6th)Malignant Hyperthermia - occurs in small population who have a genetic defect in the muscle (ryanodine receptor) calcium channel at the sarcoplasmic reticulum of the skeletal muscle.Which is triggered by halothane** to release massive Ca++ intracellularly causing persistent muscle contraction and increase heat production**. Succinylcholine** - accentuates the conditions.Treatment* Rapid external cooling* Bicarbonate infusion* 100% O2 inhalation* IV Dantrolene** 1. Thiopental** is a potent anesthetic but weak analgesic2. Nitrous oxide* - is potent analgesic but weak general anesthetic* Propofol is agent of choice for induction in susceptible individuals for malignant hyperthermia