You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Drug of choice for Chronic Myeloid Leukaemia is and explain in detail?
(B) Imatinib TRASTUZUMABMechanismMonoclonal antibody against HER-2 (erb-B2). Helps kill breast cancer cells that over express HER-2, possibly through antibody-dependent cytotoxicity.Clinical useMetastatic breast cancerToxicityCardiotoxicityIMATINIBMechanismMonoclonal antibody against the Philadelphia chromosome brc-abl tyrosine kinaseClinical useCML, Gl stromal tumorsToxicityCardiotoxicityVINCRISTINE, VINBLASTINEMechanismM-phase-specific alkaloids that bind to tubulin and block polymerization of microtubules so that mitotic spindle cannot formClinical usePart of the MOPP (Oncovin ) regimen for lymphoma, Wilms tumor, ChoriocarcinomaToxicityVincristine-neurotoxicity (areflexia, peripheral neuritis), paralytic ileus. Vinblastine blasts bone marrow (suppression)PACLITAXEL, OTHER TOXOIDSMechanismM-phase-specific agents that bind to tubulin and hyper stabilize polymerized microtubules so that mitotic spindle cannot break down (anaphase cannot break down (anaphase cannot occur)Clinical useOvarian and breast carcinomaToxicityMyelosuppression and hypersensitivity