You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Mechanism of action tacrolimus is ? and explain in detail?
Ans. is 'a' i.e., Inhibition of calcineurin Tacrolimus It is a macrolide immunosuppressant agent. Its mechanism of action is similar to cyclosporine, i.e. inhibition of transcription of IL-2 and T-cell proliferation, but it binds to other immunophilin called FKBP (in contrast to cyclosporine which binds to cyclophilin). Subsequent steps are some, i.e. inhibition of calcineurin, which inhibits T cell activation. Tocrolimus is 10-100 times more potent than cyclosporine. It is also more toxic than cyclosporin. Adverse effects are nephrotoxicity (most common), neurotoxicity, hyperglycemia (DM). Mechanism of nephrotoxicity - Periglomerular afferent aeriolar vasoconstrication and reduced GFR.