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What is Which of the following statements is not true of local anaesthetics? and explain in detail?
(Ref: KDT 6/e p352, 353) All LAs are weak bases. LAs act by blocking Na' channels from inside the neuron (intra-neuronal face). These can cross the membrane only in unionized (lipid soluble) form. Sodium bicarbonate is therefore added to make the LA rapid acting. Once inside the neuron, LAs again gets ionized and bind to Na+ channels. Binding to Na+ channels is more in repetitively firing neurons than in resting neurons.