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What is Vertical transmission is seen with which type of Hepatitis ? and explain in detail?
Ans. is 'b >d' i.e., Hepatitis B > Hepatitis C HAVHBVHCVHDVHEVCommon nameInfectious hepatitisSerum hepatitisnon A non B orPost-transfusion hepatitisDelta agentNon A non B enteric transmitted hepatitisFamilyEntero 72HepadnaFlavi viridaeViroidlikeCalci viridaeAgeChildren, young adultsYoung adults, babies, toddlersAny age, but more common in adultsAny age (similar to HBV)Young adult(20-40 years)RouteFaeco-oral (MC) blood (+/-) sexual (+/-)Blood (MC)Sexual,verticalBlood (MC)sexual (+/-)vertical (+/-)Blood (MC)sexual (++)vertical (+)Faeco-oralI.P (days)15-45mean 3030-180 mean 60-9015-160mean 5030-180mean 60-9014-60mean 40OnsetAcuteInsidiousInsidiousInsidiousAcuteFulminant0.1%0.1-1%0.1%5-20%Usually 1-2% and pregnancy 20-40%CarrierNone0 1-30%1[?]5-3[?]2%VariableNoneChronicityNoneOccasional (1- 10%) (90% of neonates)Common (85%)CommonNoneOncogenicNilPresent(neonate)Present+/-NilAssociated other featureSecondary attack rate 10-20%HCC, cirrhosis, autoimmune disorder like AGN, arthritis PANHCC, cirrhosis, autoimmune-AGN, arthritis, cryoglobulinemiaHCC, cirrhosis, fulminant hepatitisSecondary attack rate 1 -2% not seen western countriesPrognosisExcellentWorse with age, debilityModerateAcute-good chronic-poorGoodProphylaxisIG,InactivatedvaccineHBIG,recombinantvaccineNoneHBV vaccine (none for HBV carriers)Recombinant vaccineTherapyNoneInterferon lamivudine adefovir entecavirPegylated interferon plus boceprevirInterferon +- ribavirin talaprevitNone