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What is Plasmodium falciparum vaccine strain: and explain in detail?
Ans. A. RTS, S/AS01Explanation Malarial vaccinesMalarial vaccine is an area of intensive research.Several vaccines are under development, effective safe vaccine is still unavailable.SpF66: 1st vaccine developed that undergone field trial. It presents a combination of antigens from the sporozoite (using CS repeats) and merozoite parasites.NYVAC-PF.7: It blocks transmission of the parasite from vertebrate host to mosquitoes. Highly attenuated NYVAC vaccinia virus strain has been utilized to develop a multistage vaccine.RTS, S/AS01: Commercial name is mosquirix. It is most promising vaccine, engineered using genes from outer protein of P. falciparum and a portion of Hepatitis B virus, plus a chemical adjuvant to boost immune response.R-Circumsporozoite protein (repeats)T-T-cell epitopes S-HBsAgS-Genetically engineered transformed yeast strain.