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What is CRF is associated with? and explain in detail?
ANSWER: (C) Metabolic acidosisREF: Harrison 17th ed chapter 274, Essentials of Pathophysiology: Concepts of Altered Health States by Carol Mattson Forth page 200Chronic kidney disease is the most common cause of chronic metabolic acidosis. The kidneys normally conserve HCO3-- and secrete H+ ions into the urine as a means of regulating acid-base balance. In chronic kidney disease, there is loss of both glomerular and tubular function with retention of nitrogenous waste and metabolic acids. In condition called renal tubular acidosis, glomerular function is normal, but tubular secretion of H+ or reabsorption of HC03~ is abnormal.