You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following cannot be diagnosed without positive ANA? and explain in detail?
Repeated negative testing for ANA indicates least chances of having SLE. ANA is positive in 98% of patients with SLE Limited form of scleroderma known as CREST has anti centromere antibody positive and generalized form has anti topoisomerase positive antibody Anti histone antibodies are positive in drug induced lupus Anti SS-A (RO) antibodies and anti SS-B(LA) antibodies are positive in Sjogren's Syndrome