You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following mutations in a tumor suppressor agent causes breast carcinoma:- and explain in detail?
Ans. is 'b' p53 Mutation is p53 tumor suppressor gene is strongly associated with breast cancer, as well as many other sarcomas and carcinomas.This syndrome of multiple sarcomas and carcinomas, associated with mutation of p53 gene is k/a Li-Fraumeni syndrome*.