You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Cyclosporin acts by inhibiting the proliferation of: and explain in detail?
Mechanism of action of cyclosporine Normally when antigen presenting cell (e.g. macrophage) present antigen to Helper T cell, there is activation of T cell by sequential intracellular eventsFirst calcium ions, after binding to calmodulin activate a membrane serine / threonine phosphatase called calcineurin. Calcineurin activates nuclear factor of activated T cells (NFAT) by dephosphorylation. Activated NFAT migrates to nucleus and induce transcription of cytokines IL-2 and other cytokinase. IL-2 activates T cells and cause proliferation of T cells. Cyclosporine enters target cells and bind to cyclophilin (an immunophilin). This cyclosporine – cyclophilin complex inactivates calcineurin IL-2 trascripitan and proliferation of T cells