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What is Respiratory burst in neutrophils occurs due to and explain in detail?
When the cell membrane-bound enzyme NADPH oxidase is activated, with the production of toxic oxygen metabolites. The combination of the toxic oxygen metabolites and the proteolytic enzymes from the granules makes the neutrophil a very effective killing machine. Activation of NADPH oxidase is associated with a sharp increase in O2 uptake and metabolism in the neutrophil (the respiratory burst) and generation of O2- by the following reaction: NADPH + H+ + 2O2+ - NADP+ + 2H++ 2O2- O2- is a free radical formed by the addition of one electron to O2.Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page no: 64