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What is Which of the following drug should be avoided in G 6 PD deficiency and explain in detail?
Ans a) (Chloroquine) Ref Harrisonn 17th edition table 101-5DRUGS TO AVOID IN G6PD DEFICIENCYDEFINITE RISK OF HAEMOLYSISPOSSIBLE RISK OF HAEMOLYSISPharmacologicalClassDrugs*Pharmacological ClassDrugs*Anthelmintics* ss-Naphthol* Niridazole* StibophenAnalgesics* Acetylsalicylic acid (Aspirin)* Acetanilide* Paracetamol (Acetaminophen)* Aminophenazone (Aminopyrine)* Dipyrone (Metamizole)* Phenacetin* Phenazone (Antipyrine)* Phenylbutazone* Tiaprofenic acidAntibiotics* Nitrofurans- Nitrofurantoin- Nitrofurazone* Quinolones- Ciprofloxacin- Moxifloxacin- Nalidixic acid- Norfloxacin- Ofloxacin* Chloramphenicol* Sulfonamides- Co-trimoxazole (Sulfamethoxazole + Trimethoprim)- Sulfacetamide- Sulfadiazine- Sulfadimidine- Sulfamethoxazole- Sulfanilamide- Sulfapyridine- Sulfasalazine (Salazosulfapyridine)- Sulfisoxazole (Sulfafurazole) Antibiotics* Furazolidone* Streptomycin* Sulfonamides- Sulfacytine- Sulfaguanidine- Sulfamerazine- SulfamethoxypyridazoleAnticonvulsants* PhenytoinAntidiabetics* GlibenclamideAntidotes* Dimercaprol (BAL)Antihistamines* Antazoline (Antistine)Antimalarials* Mepacrine* Pamaquine* Pentaquine* Primaquine DiphenhydramineTripelennamineAntihypertensivesHydralazineMethyldopaAntimethemo- globinaemic Agents* Methylene blueAntimalarials* Chloroquine & derivatives* ProguanilAntimycobacterials* Dapsone* Para-aminosalicylic acid- Aldesulfone sodium (Sulfoxone)- Glucosulfone- Thiazosulfone * Pyrimethamine* Quinidine* QuinineAntimycobacterials* IsoniazidAntiparkinsonism Agents* Trihexyphenidyl (Benzhexol)Antineoplastic Adjuncts* Doxorubicin* RasburicaseCardiovascular Drugs* Dopamine (L-dopa)* Procainamide* QuinidineGenitourinary Analgesics* Phenazopyridine (Pyridium)Diagnostic Agent for Cancer Detection* Toluidine blueOthers* Acetylphenylhydrazine* PhenylhydrazineGout Preparations* Colchicine* Probenecid Hormonal Contraceptives* Mestranol Nitrates* Isobutyl nitrite Vitamin K Substance* Menadiol Na sulfate* Menadione* Menadione Na bisulfite* Phytomenadione Vitamins* Ascorbic acid (Vit C) (rare) Others* Arsine* Berberine (in Coptis chinensis)* Fava beans* Naphthalene (in mothballs)* Para-aminobenzoic acid