You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Most common organism in sickle cell anemia causing osteomyelitis is: and explain in detail?
a. Salmonella(Ref: Nelson 20/e p 3322; Harrison's latest 19th ed pg 634; CDC website)Nelson 20th ed says: "Salmonella & Staph aureus are the 2 most common causes of osteomyelitis in children with sickle cell anemia"; So it does not help us with the answer to this question;Harrison Latest 19th ed says: "Unusual susceptibility to osteomyelitis, which may be caused by organisms, such as Salmonella, is seen in sickle cell disease".Wintrobes Hematology also says: "Although >80% of hematogenous osteomyelitis in the general population is caused by Staphylococcus, most cases of osteomyelitis occurring in individuals with sickle cell anemia are caused by Salmonella"Microorganisms in Osteomyelitis & their Clinical Associations:Most common clinical associationMicroorganismFrequent microoganism in any type of osteomyelitisStaphylococcus aureusForeign body-associated infectionCoagulase-negative staphylococci, atypical Mycobacteria, fungiCommon in nosocomial infectionsEnterobacteriaceae, Pseudomonas aeruginosa, Candida spp.Sickle cell diseaseSalmonella spp., Staphylococcus aureus, or Streptococcus pneumoniaeExposure to kittens / catsBartonella henselaeHuman or animal bitesPasteurella multocida or Eikenella corrodensImmunocompromised patientsAspergillus spp., Candida albicans, or Mycobacteria spp.