You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Most common genentic enzyme defect in urea cycle is and explain in detail?
OTC combines carbamyl phosphate with ornithine to make citrulline which is subsequently processed tourea (see: cycle diagram). Along with CPSI and NAGS deficiency, OTCdeficiency is the most severe of theurea cycle disorders. Patients with complete OTC deficiency rapidly develop hyperammonemia in the newborn period Ref-Harpers illustrated biochemistry 30/e p583