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What is The drug inhibiting DNA-dependent RNA polymerase in Mycobacteria is - and explain in detail?
Ans. is 'b' i.e., Rifampicin Mechanism of action of impoant antitubercular drugs o Rifampicin --> Inhibits DNA dependent RNA synthesis by inhibiting RNA polymerase. o INH --> Inhibits synthesis of mycolic acid which is a component of mycobacterial cell wall. o Pyrazinamide --> Inhibits synthesis of mycolic acid. o Streptomycin --> Inhibits protein synthesis (translation). o Ethambutol --> Inhibits incorporation ofmycolic acid into bacterial cell wall by inhibiting arbinosyltransferase.