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What is Gastrointestinal stromal malignancy arises from which of the following - and explain in detail?
"Gastrointestinal stromal tumors (GIST) originate from the interstitial cells of Cajal, which controls gastrointestinal peristalsis."

On rare occasions, gastric GISTs occur as part of tumor - syndrome, such as :-


Carney's trads → Gastric GIST, Paraganglioma and pulmonary chondroma.
Neurofibromatosis Type I


Histologically, GISTs can be divided into


Spindle types → Exhibit spindle cells
Epithelioid types → Exhibit epithelioid cells
Mixed types → A mixture of both