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What is Wof anti diabetic agent is used in both type 1 and type 2 dibetes and explain in detail?
Amylin:- also called 'islet amyloid polypeptide' (IAP), is produced by pancreatic b cells and acts in the brain to reduce glucagon secretion from a cells, delay gastric emptying, retard glucose absorption and promote satiety. Pramlintide:- It is a synthetic amylin analogue which on s.c. injection before meal attenuates postprandial glycaemia and exes a centrally mediated anorectic action. The duration of action is 2-3 hours. It has been used as an adjuvant to meal time insulin injection to suppress the glycaemic peak in both type 1 and type 2 diabetics. Reduction in body weight is an additional benefit. Ref:- kd tripathi; pg num:-277,278