You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Drug given for metoclopramide dystonic reaction is- and explain in detail?
Ans. is 'b' i.e., Promethazine o We all know, blockade of D2 receptors in brain produce extrapyramidal side effects (as caused by antipsychotics), and acute muscular dystonia (dystonic reaction) is one of them. o Treatment of choice for acute muscular dystonia is central anticholinergic. o But, in given options, they have not given typical central anticholinergics. All options are typical antihistaminics. o As we also know that antihistaminics have anticholinergic propeies. So, amongst the given options we will have to choose the drug which has maximum central anticholinergic propey. First generation antihistaminics : i) Have maximum anticholinergic propey ii) Have maximum penetration of blood brain barrier For these two reasons, first generation antihistaminics have maximum central anticholinergic propey. o Amongst the given options, only promethazine is first generation antihistaminic. o Following statement of KDT will clear all doubts: "Acute muscle dystonia caused by antiemetic-antipsychotic drugs is promptly relieved by parenteral promethazine or hydroxyzine." Remember o DOC for antipsychotic induced acute muscle dystonia central anticholinergic o If central anticholinergic is not given in the options --> antihistaminic with maximum central anticholinergic propey is the DOC.