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What is Patient was given chioroquine and doxycycline for 7 days. Patients fever decreases in 4 days, but, peripheral smear showed occasional gametocytes of plasmodium falciparum. This type of drug resistance is and explain in detail?
R2 is high grade resistance i.e. reduction of parasitemia by more than 75% at 48 hours of completing treatment but failure to clear the organism within 7 days. Types of Drug Resistance : In defining criteria for resistance to the aminoquinoline antimalarial drugs. WHO has described three grades of resistance following treatment (Low grade) R1 : Recrudescence of infection between 7 and 28 days of completing treatment following initial resolution of symptoms and parasite clearance. (High grade) R2 : Reduction of parasitaemia by > 75% at 48 hours but failure to clear parasites within 7 days. R3 : Parasitaemia does not fall by >75% within 48 hours. Reference: Ghai essential pediatrics 9 th edition Page 256