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What is Diuretic used in essential hypeension is - and explain in detail?
Low dose thiazide diuretics may be used alone or in combination with other anti hypeensive agents . mechanism of action:they inhibit the Na/cl pump in distal convoluted tubule and increase sodium excretion. Drugs used are :Hydrochlohiazide,chlohalidone(long acting and more potent than hydrochlohiazide but potassium loss is greater. ) They provide additive bp lowering effects with ace inhibitors ,arb's, beta blockers. Addition of diuretic to calcium channel blocker is less effective . Ref:Harrison 20 th edition pg no 1901