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What is Primordial germ cells originate in the and explain in detail?
Primordial germ cells originate in the epiblast Primordial germ cells (PGCs), also known as primitive sex cells originate in the epiblast at the caudal end of the primitive streak. PGCs are the precursors of gametes in both genders. PGCs arise in the epiblast during the 2nd week of development. They pass through the primitive streak during gastrulation and reach the wall of the yolk sac. They migrate from the yolk sac at the 4th week and reach the developing gonads by the end of the 5th week. Ref: Gray&;s Anatomy 41st edition Pgno: 184