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What is Which of the following calcium channel blocker has a predominant peripheral action? and explain in detail?
Three groups of CCBs include: Phenylalkylamines (verapamil, nor-verapamil) Benzothiazepines (diltiazem) Dihydropyridines (nifedipine, nicardipine, nimodipine, nisoldipine, felodipine and amlodipine). By inhibiting the calcium channels, these agents result in vasodilation and decreased activity of the hea (decrease hea rate, AV conduction and contractility). Dihydropyridine (DHP) group has little direct cardiac activity and acts mainly on blood vessels, therefore are also called peripherally acting CCBs.