You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Lesch - Nyhan Syndrome - associated with and explain in detail?
It is X-linked inherited disorder of purine metabolismDeficiency of HGPase, so the rate of salvage pathway is decreased resulting in the accumulation of PRPP and decreased level of inhibitory purine nucleotide Disease is characterized by self-mutilation, mental retardation excessive uric acid and nephrolithiasis Ref: DM Vasudevan, 7th edition, page no: 568