You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Earliest feature of parkinsonism? and explain in detail?
Ans. (a) AnosmiaRef: Harrison 19th ed. / 2609Non-motor symptoms may precede motor symptoms of Parkinsons diagnosis by years. The most recognizable early symptoms include:* Loss of sense of smell, constipation* REM behavior disorder* mood disorders* Orthostatic hypotensionSubsequently Motor Features Appear1. Tremors (resting 4-6 Hz)2. Rigidity3. Bradykinesia4. Good Response to levodopa