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What is True about minimal change disease is: and explain in detail?
Ans. A. Peak incidence is between 2- 4 years of ageIn minimal change nephrotic syndrome (MCNS) (approximately 80% of total cases of nephrotic syndrome in children), the glomeruli appear normal or show a minimal increase in mesangial cells and matrix.Findings on immunofluorescence microscopy are typically negative, and electron microscopy simply reveals effacement of the epithelial cell foot processes. More than 95% of children with minimal change disease respond to corticosteroid therapy.A diagnosis other than MCNS should be considered in children <1 yr of age, with a positive family history of nephrotic syndrome, and/or the presence of extrarenal findings (e.g., arthritis, rash, anemia), hypertension or pulmonary edema, acute or chronic renal insufficiency, and gross hematuria.