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What is True regarding peussis vaccine is: and explain in detail?
Ans. (b) Erythromycin should be given to contacts Those known to have in contact with whooping cough should be given prophylactic erythromycin or ampicillin for 10 days. Peussis vaccine 1. Killed whole cell vaccine: Given in the form of DPT Protection 70-90% Adverse reaction: Neurologic complication 1:170000 Convulsions Prolonged screaming Hyporesponsible state. Contraindication: Epilepsy, convulsion or other CNS disorder. 2. Acellular vaccine: Contain peussis toxoid and filamentous hemagglutinin. Same efficacy but less reactogenic Two component (which contain peactin and peussis toxoid. are more effective than monocomponent acellular vaccine. The fuher addition of fimbriae appears to enhance protective efficacy. Note: In peusis lymphocytosis (not leukocytosis) is diagnostic.