You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Drug X is normally administered to patients at a rate of 50 mg/hour. Elimination of the drug X from body takes place as: - Hepatic Metabolism 10% - Biliary Secretion 10% - Renal Excretion 80% This drug has to be administered to a 65 years old patient Uttaam Singh, with a GFR of 60 ml/min. (assuming normal GFR is 120ml/min). Liver and biliary functions are normal in this patient. What should be the dose rate of drug X in this patient? and explain in detail?
* In this question 80 percent of drug is eliminated by renal route and 20 percent by non-renal routes (10 percent by hepatic metabolism and 10 percent by biliary secretion). * This patient has 50 percent renal function (60 ml/min of GFR instead of 120 ml/min). Thus, the drug that can be eliminated in this person is 20 percent (Non-renal route) + 40 percent (Renal route; 50 percent of 80 percent) = 60 percent * Thus, the dose rate should be 60 percent of the original. i.e. 50 mg/hr x 60 percent = 30 mg/hr.