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What is Which of the following condition(s) are associated with raised ANCA except and explain in detail?
Many patients with vasculitis have circulating antibodies that react with neutrophil cytoplasmic antigens, so-called anti-neutrophil cytoplasmic antibodies (ANCAs). ANCAs are a heterogeneous group of autoantibodies directed against constituents (mainly enzymes) of neutrophil primary granules, monocyte lysosomes, and endothelial cells. ANCAs are very useful diagnostic markers; their titers generally mirror clinical severity, and a rise in titers after periods of quiescence is predictive of disease recurrence. PR3-ANCAs are associated with Wegener granulomatosis. MPO-ANCAs are associated with microscopic polyangiitis and Churg-Strauss syndrome. (Robbins Basic Pathology,9th edition,pg no.350)