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What is Medication used in treatment of idiopathic central precolcious pubey : and explain in detail?
GnRH agonist therapy in Precocious Pubey : It arrests the pubeal precocity and growth velocity . The agonists supress the premature activation of HPO axis due to downregulation and thereby diminished estrogen secretion GnRH agonist therapy is the drug of choice in cases with GnRH dependent(central) precocious pubey It supresses FSH and LH secretion which reverses ovarian cycle and establishes amenorrhea and regression of breast Dose: Buserelin nasal spray 100 microgram daily Ref: D.C..DUTTA'S TEXTBOOK OF GYNAECOLOGY; 6th edition; Pg no:53