You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is During homeostasis, platelet affects the coagulation area : and explain in detail?
A i.e. Platelet adhesion to exposed endothelium B i.e. Clot retraction C i.e. Activation of prothrombinase complexRole of Platelets in Hemostasis- VasoconstrictionQ d/t release of TXA2 and serotonin- Adherence : The glycoprotein of cell membrane platelet cause adherence to exposed endothelium (but repulses to normal endothelium)- Platelet plug formation closing small vascular holes- Conversion of prothrombin to thrombin: Activation of prothrombinase complex+2 (consisting of platelet anionic phospholipids Ca++, factor Va, factor Xa and prothrombin) on the surface of activated platelet lit conversion of prothrombin into thrombin- Stabilization of fibrin: Fibrin stabilization factor released from platelet cause stablization of fibrin (Polymerization of fibrin)- Thrombin causes conversion of fibrinogen to fibrin- Fibrinous organization of blood clot d/t growth factors secreted by platelet- Clot retraction & contraction d/t contractile proteins actin, myosin and thrombosthenin