You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The chronic granulomatous disease is and explain in detail?
defects in the phagocyte oxidase (NADPH oxidase) enzyme, the cause of chronic granulomatous disease In these patients, engulfment of bacteria does not result in activation of oxygen-dependent killing mechanisms. In an attempt to control these infections, the microbes are surrounded by activated macrophages, forming the "granulomas Tuberculosis is the prototype of the granulomatous diseases but sarcoidosis, Crohn's disease, cat-scratch disease, leprosy, brucellosis, syphilis, some mycotic infections, berylliosis, and reactions of irritant lipids are also included. it is a congenital and not acquired leukocyte function defect ref:-robbins 9th ed, page 79