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What is The insulin preparation of choice in diabetic ketoacidosis is and explain in detail?
Diabetic ketoacidosis (Diabetic coma) Ketoacidosis of different grades generally occurs in insulin dependent diabetics. It is infrequent in type 2 DM. The most common precipitating cause is infection; others are trauma, stroke, pancreatitis, stressful conditions and inadequate doses of insulin Treatment of DKA:- 1. Insulin:- Regular insulin is used to rapidly correct the metabolic abnormalities. A bolus dose of 0.1-0.2 U/kg i.v. is followed by 0.1 U/kg/hr infusion; the rate is doubled if no significant fall in blood glucose occurs in 2 hr. Fall in blood glucose level by 10% per hour can be considered adequate response. Usually, within 4-6 hours blood glucose reaches 300 mg/dl. Then the rate of infusion is reduced to 2-3 U/hr. This is maintained till the patient becomes fully conscious and routine therapy with s.c. insulin is instituted. 2) I v. Fluids 3) kcl Ref:- kd tripathi; pg num:-267,268