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What is Which of the following is not seen in acute hepatitis B infection and explain in detail?
Ans: d (IgG anti HBsAg) Ref:Ananathanarayan, 7th ed, p. 557IgG anti HBsAg is not a marker of acute Hep B infection, it is a marker of chronic Hep B infectionHBsAg (Hep B surface antigen) -It is a protein which is a part of viral envelope.HBcAg(Hep B core antigen)-It is a protein which makes up the capsid or core part.It is found in liver not in blood.HBeAg(Hep B e antigen)-It is a part of HBcAg which can be found in the blood and indicates infectivity.Schematic diagram of hepatitis B virusThis is one of the most important topics in entrance examination, so it is necessary to understand completely the serological patterns in HB V infection.Important points First virological marker detectable isHBsAgEarliest antibody marker in bloodIgM Anti HBcDiagnostic marker of acute Hep B infectionIgM Anti HBcMarker of infectivityHBeAgMarkers of replicative phase HBeAg -> Qualitative markerHBV DNA -> Quantitative markerAnti HBsAg without anti HBcVaccinatedAnti HBsAg with IgG anti HBcRecovery from infection