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What is QT prolongation is caused by: and explain in detail?
Ans. a. QuinidineRef: Goodman Gilman 12th e/P. 821Drugs Causing QT prolongation:Antihistamines: Class la (Quinidine) and Class IIICisaprideAntipsychotics: Ziprasidone, sertindole, quetiapine, haloperidol, etc.Antidepressants: Tricyclic antidepressants like amitriptyline, SSRI like fluoxetineAntibiotics: Fluoroquinolones, erythromycinAntihistaminics: Astemizole, terfenadineAntifungals: KetoconazoleAntimalarials: Chloroquine, quinine, halofantrineAntivirals: Amantadine