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What is DOC for acute organophosphate poisoning is: and explain in detail?
Atropine  
It is highly effective in counteracting the muscarinic symptoms, but higher doses are required to antagonize the central effects. It does not reverse peripheral muscular paralysis which  is a nicotinic  action.  
All cases of anti-ChE  (carbamate or organophosphate) poisoning must be promptly given atropine 2 mg i.v. repeated every 10 min till dryness of mouth or other signs of atropinization appear (upto 200 mg has been administered in a day). Continued treatment with maintenance doses may be required for 1- 2  weeks. 
Reference: Essentials of Medical Pharmacology Eighth Edition KD  TRIPATHI  page no 122,123