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What is Loading dose of a drug depends upon: and explain in detail?
Ans. (A) Volume of distribution(Ref: KDT 8th/41)Loading dose: It is mainly used for drugs having long t1/2 and large volume of distribution. It is given to load (saturate) the tissue stores. So it is mainly dependent on Vd.Loading dose = VD x Target plasma concentrationMaintenance dose: It is mainly dependent on CL.Maintenance dose = CL x Target plasma concentration