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What is Select the antimicrobial drug which is used orally only for urinary tract infection or for bacterial diarrhoeas and explain in detail?
QUINOLONES Nalidixic acid It is active against gram-negative bacteria, especially coliforms: E. coli, Proteus, Klebsiella, Enterobacter, Shigella but not Pseudomonas. mech of action:- It acts by inhibiting bacterial DNA gyrase and is bactericidal. Use s:- 1. Nalidixic acid is primarily used as a urinary antiseptic. 2. It has also been employed in diarrhoea caused by Proteus, E. coli, Shigella or Salmonella, but norfloxacin/ciproloxacin are more commonly used now. Ref:- kd tripathi; pg num:-709