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What is Which of the following hormones are secreted by Pheochromocytoma to cause its clinical manifestations? and explain in detail?
Hypeension in pheochromocytoma results from the direct effect of high circulating levels of catecholamines, primarily noradrenaline, adrenaline, and dopamine. Some tumors produce the catecholamine precursor L-dopa. Pheochromocytomas also secrete numerous other peptide hormones, among which are renin, VIP, neuropeptide, Y, somatostatin, and ET-1. These substances are responsible for many of the nonhypeensive symptoms seen in patients with pheochromocytoma, including flushing, sweating, and diarrhoea. Ref: Pediatric Nephrology, 5e By Ellis D. Avner, William E. Harmon, Ellis D. Avner William Harmon Patrick Niaudet, 2003, Page 1167; Harrison's Internal Medicine > Chapter 337. Pheochromocytoma