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What is Which of the following statements are true about mifepristone : and explain in detail?
Ans. is a, b, c Also called RU - 486; It is a 19 Norsteroid; Acts on receptors; Used for menstrual regulation Route of administration : Oral RU 486 (Mifepristone) is a 19 Norsteroid synthetic derivative of progesterone. It has affinity for progesterone receptors and therefore blocks its actions. Uses : As post coital (600mg given within 72 hrs. of unprotected sex). To induce aboion upto 7 weeks of amenorrhea along with mesoprostol (medical aboion). Ripening of cervix prior to prostaglandin induction of mid trimester aboion. Management of ectopic pregnancy. Cushing's syndrome : because of its antiglucocoicoid action. Medical management of uterine fibroid. Headache GI upset Adrenal failure Teratogenesity (If medical methods of aboion fails with RU - 486, pregnancy should be terminated any how). Contraindication : * Adrenal failure Cardiac disease Asthma Haemorrhagic disease Glucoma Woman on long term glucocoicoid therapy and anticoagulants.