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What is Haemoglobin synthesis starts with? and explain in detail?
ANSWER: (A) GlycineREF: Harper 26th e p. 271-275Steps of porphyrin ring synthesis:EnzymeLocationSubstrateProductporphyriaALA synthaseMitochondrionGlycine, sucdnyl CoAD-Aminolevoilinic acidnoneALA dehydrataseCytosolD-Aminolevulinic acidPorphobilinogenALA-DehydratasedeficiencyPEG deaminaseCytosolPorphobilinogenHydroxymethyl bilaneAcuteintermittentporphyriaUroporphyrinogen III synthaseCytosolHydroxymethyl bilaneUroporphyrinogen IIICongenitalerythropoieticporphyriaUroporphyrinogen III decarboxylaseCytosolUroporphyrinogen IIICoproporphyrinogen IIIPorphyria cutanea tardaCoproporphyrinogen III oxidaseMitochondrionCoproporphvrinogen IIIProtoporphyrinogen IXCoproporphyriaProtoporphyrinogenoxidaseMitochondrionProtoporphyrmogen IXProtoporphyrin IXVariegateporphyriaFerrochelataseMitochondrionProtoporphyrin IXHemeErythropoieticprotoporphyriaHeme synthesis--note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)