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What is What is the macromolecular complex that associates with introns during mRNA splicing? and explain in detail?
A special multicomponent complex, the spliceosome, is involved in conveing the primary transcript into mRNA. Spliceosomes consist of the primary transcript, five snRNAs (U1, U2, U4, U5, and U6) and more than 60 proteins, many of which contain conserved "RNP" and "SR" protein motifs. Ref: Weil P. (2011). Chapter 36. RNA Synthesis, Processing, & Modification. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds),Harper's Illustrated Biochemistry, 29e.