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What is Flatbush diabetes is associated with: and explain in detail?
A i.e. Type 1 DMRef: Bhansali A, et al. Clinical Rounds in Endocrinology: Volume II - Pediatric Endocrinology, page 423Explanation:Flatbush DiabetesDescribed in African American young adults residing in an area named Flatbush in New York city, USA. Now increasingly seen in Africa as well.Variant of Type 1 diabetes but without any markers of autoimmunity.Also known as atypical diabetes, type 1B diabetes, idiopathic type 1 diabetes and ketosis-prone type 2 diabetes.These young adult patients presented with diabetic ketoacidosis but required insulin only for a short period. They were maintaining euglycemia for long period after tapering and stopping insulin.Exact mechanism of this condition is not known. Proposed mechanisms include: o Severe oxidative stress.Glucotoxicity mediated beta cell dysfunction,Insulin resistance.Most cases present with sudden onset of very high blood glucose and ketosis (DKA).Most of these patients were overweight/obese*.Strong family history* of diabetes present (90%).No evidence of autoimmunity against islet cells.Beta cell function relatively preserved.Patients may relapse with DKA*.