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What is Wof bones is affected more with glucocoicoid induced osteoporosis and explain in detail?
Adverse effects:- Osteoporosis Especially involving veebrae and other flat spongy bones. Compression fractures of veebrae and spontaneous fracture of long bones can occur, especially in the elderly. Radiological evidence of osteoporosis is an indication for withdrawal of coicoid therapy. Coicosteroid induced osteoporosis can be prevented/arrested by calcium supplements + vit D, and by estrogen/raloxifene or androgen replacement therapy in females and males respectively. However, bisphosphonates are the most effective drugs. Avascular necrosis of head of femur, humerus, or knee joint is an occasional abrupt onset complication of high dose coicosteroid therapy. Ref:- kd tripathi; pg num:-293