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What is Syndrome of apparent mineralocoicoid excess is due to? and explain in detail?
Coisol can stimulate mineralocoicoid receptors. But renal inactivation of coisol occurs to form coisone and thereby BP remains normal. SAME (Syndrome of Apparent Mineralocoicoid Excess) leads to lack of this inactivation. The resultant increase in coisol leads to excess activation of mineralocoicoid receptor and results in hypeension.