You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is 'Lacunar cells' are peculiarly seen in which variety of Hodgkin's lymphoma? and explain in detail?
Ans. A. Nodular Sclerosis. (Ref Robbings Pathology 8th/pg. page 456)SUBTYPES OF HODGKIN'SFEATURESNodular sclerosis (65-75%)- Common in females ; Excellent prognosis- Most common worldwide- Lacunar cells common- Diagnostic RS cells- Fibrous collagen- Bands dividing cellular areas into nodules- RS cells CD15+, CD30+Mixed cellularity (25%)- Plenty of classic RS cells and mononuclear variants- CD15+ CD30+ RS cells.- Most common in India.Lymphocyte predominance (6%)- Lymphohistiocytic variants- Popcorn cells - Polypoid RS cells- RS cells- CD20+- CD CD30-Lymphocyte depletion (3-5%)- Worst prognosis- Rare- CD15+, CD30+- Reticular variants- Controversial entity