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What is Knuckle pads and explain in detail?
Knuckle pads (also known as "Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints. They are described as well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time.Knuckle pads are sometimes associated with Dupuytrens contracture and camptodactyly,: 595  and histologically, the lesions are fibromas.: 595  Knuckle pads are generally non-responsive to treatment, including corticosteroids, and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil.

See also
Skin lesion
List of cutaneous conditions
Garrods pad

References
Further reading
Guberman D;  et al. (1996). ""Knuckle pads-a forgotten skin condition " report of a case and review of the literature". Cutis. 57 (4): 241–242. PMID 8727774.
Ly Y;  et al. (2003). "A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads"