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What is True about fibrates are all except and explain in detail?
The fibrates primarily activate lipoprotein lipase which is a key enzyme in the degradation of VLDL resulting in lowering of circulating TGs. Main side effects are G.I. upset, myalgia, rashes. Fibrates act through peroxisome proliferator-activated receptor a (PPAR alpha) that is a gene transcription regulating receptor expressed in liver, fat, and muscles. Activation of PPARa enhances lipoprotein lipase synthesis and fatty acid oxidation. They are taken before meals. Thiazolidinediones prescribed for diabetics will block PPAR Gamma (REF. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D TRIPATHI-6th edition.Page No-616,617)