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What is Amplification of N-Myc is associated with which a tumor? and explain in detail?
Amplification of N-Myc is associated with a variety of tumors, most notably neuroblastomas.
This gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.