You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is not a new drug for Migraine? and explain in detail?
Option 1 Lasmiditan Highly affinity for 5-HT1Freceptor agonist Acts on trigeminal system without causing vasoconstriction Low affinity for 5-HT1Breceptors Acute therapy for migraine in patients with cardiovascular risk factors Option 2 Ubrogepant Calcitonin gene related peptide (CGRP) receptor antagonist Acute treatment of migraine attacks Option 3 Rimegepant Only CGRP antagonists that possess oral bioavailability Acute treatment migraine headache Option 4 Romosozumab Sclerostin inhibitor Treatment of osteoporosis in postmenopausal women at high risk for fracture Monoclonal antibodies that antagonize the CGRP pathway are: Galcanezumab Eptinezumab Fremanezumab(which all target the CGRP peptide) Erenumab ( fully human mAb designed to target the CGRP receptor). =Standard migraine Rx involves "triptans", but these are C/I in patients with pre-existing cardiovascular disease due to their vasoconstrictive propeies.