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What is Classical triad of global confusion, ataxia and ophthalmoplegia is seen in and explain in detail?
Wernicke&;s encephalopathy is an acute reaction to a severe deficiency of thiamine, the commonest cause being chronic alcohol use. Impoant clinical signs: Ocular signs- coarse nystagmus and ophthalmoplegia with bilateral external rectus paralysis occurring early. Higher mental function disturbances-disorientation, confusion, recent memory disturbances, poor attention span and distractibility are quite common. Other early symptoms are apathy and ataxia (Ref: a sho textbook of psychiatry, Niraj Ahuja, 7th edition, pg no.38)