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What is Mechanism of action of actinomycin D is - and explain in detail?
Ans. is 'a' i.e.. Inhibits DNA dependent RNA synthesis The anticancer antibiotics are :o Actinomycin - D (Dactinomycin)o Daunorubicin (Rubidomycin)o Mitomycin C* Doxorubicino Mitoxantroneo Mithramycin (plicamvcin)o Bleomycins o These anticancer, antibiotics obtained from micro-organisms and have prominent antitumour activity,o Mechanism of action : They are intercalated betw een DNA strands and interfere w ith its template functionActinomycin "D' inhibits DNA dependent RNA synthesis.Bleomycin cause DNA breakage and free radical formation .Doxo-and daunorubicin inhibit Topoisomerase I & II.Mitomycin acts like alkylating agents.Mitoxantrane binds to DNA to produce strand breakage and inhibits both DNA & RNA synthesis.RememberAll antitumor antibiotics are cell cycle nonspecific except for bleomycin which acts in G2 phase.