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What is True about TB in HIV infection - and explain in detail?
Worldwide, approximately one-third of all AIDS-related deaths are associated with TB, and TB is the primary cause of death for 10-15% of patients with HIV infection.TB is one of the conditions associated with HIV infection for which cure is possible with appropriate therapy. Therapy for TB is generally the same in the HIV-infected patient as in the HIV-negative patient . Due to the possibility of multidrug-resistant or extensively drug-resistant TB, drug susceptibility testing should be performed to guide therapy. Due to pharmacokinetic interactions, adjusted doses of rifabutin should be substituted for rifampin in patients receiving the HIV protease inhibitors or nonnucleoside reverse transcriptase inhibitors. (Harrison's Principles of internal medicine, 20 th edition, page 1548 )