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What is Glucocorticoid remediable aldosteronism and explain in detail?
Glucocorticoid remediable aldosteronism also describable as aldosterone synthase hyperactivity, is an autosomal dominant disorder in which the increase in aldosterone secretion produced by ACTH is no longer transient.
It is a cause of primary hyperaldosteronism.

Symptoms and signs
Patients with GRA may be asymptomatic, but the following symptoms can be present:
Fatigue
Headache
High blood pressure
Hypokalemia
Intermittent or temporary paralysis
Muscle spasms
Muscle weakness
Numbness
Polyuria
Polydipsia
Tingling
Hypernatraemia
Metabolic alkalosis

Normal Physiology
Aldosterone synthase is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone. It is localized to the mitochondrial inner membrane