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What is All of the following are true about treatment of migraine, EXCEPT: and explain in detail?
Sumatriptan is an agonist at 5-HT serotonin receptors, in paicular 5HT 1B/1Dreceptors. It is used in the treatment of acute migraine attacks but is not recommended for migraine prophylaxis. The drug provides rapid relief of migraine headache as well as relief of the associated manifestations of migraine including nausea, vomiting, photophobia and phonophobia. Sho-acting, rapidly effective triptans include almotriptan, sumatriptan, rizatriptan, zolmitriptan, and eletriptan, whereas naratriptan and frovatriptan have the longest half-lives. 5HT 1B/1Dreceptor agonists are sumatriptan, naratriptan, rizatriptan, and zolmitriptan. Ref: Instant Pharmacology By Kourosh Saeb-Parsy, Ravi G. Assomull, Fakhar Z. Khan, Kasra Saeb-Parsy, Eamonn Kelly, 1999, Page 300 ; Harrison's 17th ed chapter 15