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What is Agent used for eliciting diagnostic differentiation of Myasthenia Gravis from Cholinergic crisis is and explain in detail?
Edrophonium test * Edrophonium test is used to distinguish between Myasthenic crisis of autoimmune Myasthenia Gravis and Cholinergic crisis. * Edrophonium is a sho acting reversible non-carbamate Acetylcholinesterase inhibitor (indirectly acting cholinomimetic). * It is based on the scientific rationale that muscular weakness of myasthenic crisis (caused by inadequate cholinergic stimulation) dramatically improves on administration of Edrophonium. * In Cholinergic crisis - caused by overeatment with anticholinesterases --> resulting in muscle weakness by induction of persistent depolarization, fuher administration of Edrophonium causes drastic worsening of muscle weakness. Ref:- Goodman & Gilman Pharmacological Basis of Therapeutics 13th Ed; Pg num:- 172