You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Inhibition of which of the following vitamin is caused by Isoniazid? and explain in detail?
Isoniazid inhibits pyridoxal phosphokinase You know that the biologically active form of pyridoxine is pyridoxal phosphate.Thus, Isoniazid inhibits the formation of the active form of B6. Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy. As Vit B6 (PLP) is required for Niacin synthesis from tryptophan, hence Isoniazid therapy also causes Niacin deficiency.