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What is Which of the following is false - and explain in detail?
Ans. (d) Diffuse large B cell lymphoma(Ref: Robbins 9th/pg 597; 8th/pg 607; WHO Hemato- lymphoid Tumors 4TH ed 2008, pg231, 264)Discussing the options one by one,*. BCL-6: Burkitts lymphomaTrue, CD19, CD20, CD22, CD10, Bcl6 are positive in Burkitt's*. BCL-2: Follicular lymphomaTrue, CD19, CD20, CD22, CD10, Bcl2 are positive in Follicular Lymphoma*. CD-10: Mantle cell lymphomaTrue, CD19, CD20, CD22, CD5, FMC-7, CD43 positive while Cd10 & Bcl6 negative in Mantle cell Lymphoma;Blastoid / pleomorphic variants are CD5 -ve, CD10+, Bcl6 +ve*. CD 34: Diffuse large B cell lymphomaFalse CD19, CD20, CD22, CD79a, CD10 & Bcl6 are positive is DLBCLCD34 is a marker of blasts, so positive in Acute Leukemia