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What is KIM-1 is a novel biomarker for and explain in detail?
Kidney injury molecule-1 (KIM-1) is a type 1 transmembrane protein that is abundantly expressed in proximal tubular cells injured by ischemia or nephrotoxins such as cisplatin. KIM-1 can be detected sholy after ischemic or nephrotoxic injury in the urine and, therefore, may be an easily tested biomarker in the clinical setting. Neutrophil gelatinase-associated lipocalin (NGAL, also known as lipocalin- 2 or siderocalin) is another novel biomarker of AKI. Other candidate biomarkers of AKI include interleukin (IL) 18, a proinflammatory cytokine of the IL-1 superfamily Ref: Harrison 19e 1808