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What is Family of Toll-like receptors (TLRs) are? and explain in detail?
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.They are the Most impoant receptors for microbial products to initiate acute inflammation. Ref - Harrison's internal medicine 20e p1067,2511