You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Glycogen containing cells is feature of and explain in detail?
Ans. a (Ewing's sarcoma). (Ref. Robbin, Pathology, 6th ed., 1244)EWING'S SARCOMA# Ewing's sarcoma constitutes -10-15% of all bone sarcomas# Is common in adolescence (peak incidence in the second decade of life).# It typically involves the diaphyseal region of long bones, Also has an affinity for flat bones.# X-ray: characteristic 6ionion peel" periosteal reaction with a soft tissue mass (better seen by MRI).# The soft mass is composed of sheets of monotonous, small, round, blue cells and can be confused with lymphoma, embryonal rhabdomyosarcoma, and small-cell carcinoma.# It is composed of sheets of uniform small, round cells that are larger than lymphocytes, rich in glycogen with Homer- Wright rosettes (tumor cells with PAS positive Glycogen-filled cytoplasm characteristic).# The presence of p30/32, the product of the mic-2 gene (which maps to the pseudoautosomal region of the X and Y chromosomes) is a cell-surface marker for Ewing's sarcoma (and other members of PNETs).# In approximately 85% of patients t (11;22) (q24;ql2) translocation is seen.# It is Undifferentiated--high grade tumor (Ewing's is always classed G4).# It is very aggressive, and it is therefore considered a systemic disease.# Common sites of metastases are lung, bones, and bone marrow.# Ewing's sarcoma can be curable, even in the presence of metastatic disease, especially in children <11 years.# Systemic chemotherapy is the mainstay of therapy, often being used before surgery.# Local treatment for this tumor includes surgical resection, usually with limb salvage or radiation therapy.# More PNETs are known to arise in soft tissues; which include -- Peripheral neuroepithelioma,- Askin's tumor (chest wall), and- Esthesioneuroblastoma.Other small round cell tumors includeQ TumorClassic cytogenetic abnormality1.Wilm's tumor11p13deletion/mutation2.Lymphoblastic lymphoma (ALL)t (9;12)3.Rhabdomyosarcomat (2;13), llpdeletion4.Neuroblastomalpdeletion,N-myc amplification,DNA hyperploidy5.Medulloblastoma17q6.Retinoblastoma13q14deletion/mutation7.Ependymoblastoma 8.Burkit's lymphomat (11;22)9.Small cell carcinoma Note: Osteosarcoma is not a round cell tumor.