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What is The nitrates which can undergo the ﬁrst-pass metabolism: and explain in detail?
Organic nitrates are lipid-soluble: well absorbed from buccal mucosa, intestines and skin. Ingested orally, all except isosorbide mononitrate undergo extensive and variable first pass metabolism in liver.They are rapidly denitrated by a glutathione reductase and a mitochondrial aldehyde dehydrogcnase.
 
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 587