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What is All are true about HMG CoA reductase inhibitors except- and explain in detail?
Ans. is 'd' i.e., Fibrinogen levels are increased by provastatin o Fibrinogen levels are not increase but decreased by Provastatin. o Simvastatin and Lovastatin are lipophilic drugs therefore their CNS penetration is more than pravastatin and fluvastatin which are hydrophilic drugs. o All statins, except rosuvastatin and pravastatin are metabolized. o Absorption of the statins is enhanced by taking the dose with food, except for pravastatin whose absorption is only minimally affected.