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What is Tumor marker for primary hepatocellular carcinoma are all except and explain in detail?
Tumor markers for Hepatocellular carcinoma Protein induced by Vitamin K absence (PIVKA;Des-gamma-carboxy prothrombin) ;glypican-3 ; AFP fractions Lectin fraction-3 of AFP (AFP-L3) is highly specific to HCC and also an indicator of poorly differentiated histology and unourable prognosis Serum AFP level is elevated above 20 ng/ml in >70% of patients with HCC Monoclonal antibody HepPar-1 (hepatocyte paraffin - 1) identifies a unique antigen on hepatocyte mitochondria and is used to identify hepatocytes or HCC Ref : Sabiston 20th edition Pgno : 1458-1463