You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Metabolic alkalosis is caused by and explain in detail?
Ans: a (Repeated vomiting)Ref: Vasudevan & Sreekumari, 6th edi., Pg. 351METABOLIC ALKALOSISPrimary changeExcess of bicarbonate Bicarbonate level >33 mmol/L pH increased > 7.42Secondary change Increase in PaC02 (compensation)CAUSES OF METABOLIC ALKALOSISChloride responsiveProlonged vomiting,Nasogastric suctionChloride resistantMineralocorticoid excessPrimary secondary hyperaldosteronismUpper GI obstructionGlucocorticoid excessBarter's syndromeCushing's syndrome,Adrenal tumourLoop diuretics - blocks reabsorption of sodium, potassium and chlorideExogenous bases - intravenous bicarbonate, massive blood transfusion, antacids, milk alkali syndrome, and sodium citrate overload.