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What is Which one of the following is HLA-associated diabetes mellitus? and explain in detail?
Type 1 diabetes mellitus is also called HLA associated diabetes. Type 1 diabetes shows genetic susceptibility. Most impoant locus is the HLA gene cluster on chromosome 6p21,which according to some estimates contributes as much as 50% of the genetic susceptibility to diabetes. (Ref:ROBBINS Text book of pathology)