You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Mercury affects which part of the kidney - and explain in detail?
Ans. (a) PCT(Ref: Robbins 9th/pg 928; 8th/pg 938)Nephrotoxic AKI*Caused by Gentamicin, radiographic contrast agents, heavy metals (eg mercury), organic solvents (eg CCl4 ).*Extensive necrosis along mainly proximal convoluted tubule (PCT) & ascending limb of Henle's loop.*On histologic examination, non-specific tubular necrosis, with some distinctive features:Mercuric chlorideSeverly injured cells contain large acidophilic inclusions, become totally necrotic, & may undergo calcification.Carbon tetrachlorideAccumulation of neutral lipids (fatty change), followed by necrosis.Ethylene glycolMarked ballooning & hydropic or vacuolar degeneration of proximal convoluted tubules. Ca oxalate crystals are often found in the tubular lumens in such poisoning.