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What is Wof sulfonylureas is used in treatment of neurogenic diabetes Insipidus and explain in detail?
Chlorpropamide:- is one of the first SUs which has been discontinued because of long duration of action (> 2 days) and frequent hypoglycaemia. Side effects:- It was also prone to cause dilutional hyponatraemia (by sensitizing kidney to ADH action- used in treating central DI), cholestatic jaundice and alcohol flush(disulfiram like reaction). Ref:- kd tripathi; pg num:-273