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What is A 30 years old female presents with a diffuse thyroid swelling. On investigation, TSH levels were elevated. Post-operative HPE repos showed intense lymphocytic infiltration and Huhle cells. Which of the following is the most likely diagnosis? and explain in detail?
HASHIMOTO'S THYROIDITIS- AkaStruma Lymphomatosa(conversion of thyroid tissue into lymphoid tissue) - Auto immune disorder -Anti- TPO (anti thyroid peroxidase) autoantibody - Associated with HLA B- 8, DR-3, D Clinical features - Signs & symptoms of Hypothyroidism Permanent destruction of follicles-> permanent hypothyroidism - Diagnosis is done by detection of anti TPO antibodies - FNAC Increased lymphocytic infiltration Presence ofHuhle cells/ Askanazy cells. Treatment Lifelong levothyroxine If Suspicion of malignancy - Total thyroidectomy