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What is Nimodipine is approved for use in: and explain in detail?
Ans: D. Subarachnoid hemorrhage(Ref: Harrison 19/e p1787, 1735; Ratting 13/e p202, 12/e p204).Nimodipine is approved for use in subarachnoid hemorrhage.Subarachnoid hemorrhage:Typically treated with the calcium channel blocker nimodipine, aggressive IV fluid administration, and therapy aimed at increasing blood pressure, typically with vasoactive drugs such as phenylephrine.The IV fluids and vasoactive drugs (hypeensive hypervolemic therapy) are used to overcome the cerebral vasospasm.Early surgical clipping or endovascular coiling of aneurysms is advocated to prevent complications related to re-bleeding.Hydrocephalus, typically heralded by a decreased level of consciousness, may require ventriculostomy drain.