You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 85-year-old female developed multiple blisters on trunk and thigh. Nikolsky's sign negative. The lesions came on and off. The most probable diagnosis is: and explain in detail?
Elderly patient, -ve nikolsky sign and multiple blisters on trunk and thigh point towards BP Other features BP AI subepidermal blistering disease. MHC II - HLA-DQ1*0301 is prevalent. Oral mucosal lesions are found rarely (10-40%) Pruritus +/- Nontraumatized blisters heal without scarring Tense blisters-->rupture--> flaccid lesions/ erosions+/- surmounting crust Rx: Mainstay- systemic glucocoicoids -Prednisone, 40 to 60 mg/d.(good response) Azathioprine (1-2 mg/kg/day), Mycophenolate mofetil (20-35mg/kg/day), or Cyclophosphamide (1-2 mg/kg/day)