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What is A 10-year-old child with sho stature presented to the pediatric OPD with external ophthalmoplegia, gait abnormality, sensorineural hearing loss. Lab findings revealed raised fasting blood glucose levels. ECG Fundus examination Which of the following is true about the DNA involved in the above disease: - and explain in detail?
This is a case of Kearns-Sayre syndrome. Multi-organ disorder External ophthalmoplegia Hea block Retinitis pigmentosa Dementia, SNHL and multiple endocrine abnormalities Mitochondrial inheritance Mitochondrial DNA Circular Has several copies of single mtDNA molecule Free of nuclear envelope Not packed into chromatin Encodes for 13 genes