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What is True about acute post infective glomerulonephritis ? and explain in detail?
Ans. is 'd' i.e., Deposition of IgAPost streptococcal (Acute proliferative) glornerulonephritis Post streptococcal glornerulonephritis (PSGN) is an acute proliferative glomerulonephritis which is characterized by diffuse proliferation of glomerular cells, associated with influx of leukocytes. o PSGN is characterized by -i) Enlarged, hypercellular glomeruli that is caused byInfiltration of leukocytes, both neutrophils and monocytes.Proliferation of endothelial cells and mesangial cells.Proliferation and leukocyte infiltration is diffuse, i.e. involving all lobules of all glomeruli.ii) In severe form --> Crescent formation.iii) By immunofluorescence microscopy, there are granular deposits of IgG, IgM and C3 in the mesangium and along the basement membrane.iv) The characteristic electron microscopic findings are discrete, amorphous, electron dens deposits on the epithelial side of the membrane, often having the appearance of humps - Subepithelial humps.v) Subendothelial, intramembranous (within GBM) and mesangial deposits may be present.Also knowIn its severe form acute diffuse proliferative GN may show rapid deterioration of renal function with formation of crescent in the glomeruli - it is referred as rapidly progressive glomerulonephritis.