You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The organism most frequently related to mediastinal fibrosis is - and explain in detail?
The organism most frequently related to mediastinal fibrosis is Histoplasma.
• The spectrum of chronic mediastinitis ranges from granulomatous inflammation of the lymph nodes in the mediastinum to fibrosing mediastinitis.
• Most cases are due to TB or histoplasmosis, but sarcoidosis, silicosis, and other fungal diseases are at times causative.
Clinical Features
• Patients are usually asymptomatic.
• Those with fibrosing mediastinitis usually have signs of compression of some mediastinal structure such as the SVC or large airways, phrenic or RLN paralysis, or obstruction of the pulmonary artery or proximal pulmonary veins.
Treatment
• Other than ATT for tuberculous mediastinitis, no medical or surgical therapy has been demonstrated to be effective for mediastinal fibrosis.