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What is Concomitant administration of this drug with organic nitrates is contraindicated due to marked potentiation of vasodilatory action leading to profund hypotension. This drug is: and explain in detail?
(Ref: KDT 6/e p525) Nitrates release No, that acts by increasing cGMP. Phosphodiesterase inhibitors like sildenafil inhibits the breakdown of cGMP. Concomitant use of these two drugs may result in profound hypotension.