You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is ADAMTS 13 is associated with: and explain in detail?
Ans. a. TTPThrombotic thrombocytopenic purpura (TTP) is a rare disorder of hemostasis in which there is widespread intravascular formation of fibrin-platelet thrombi.It is sometimes associated with an acquired or inherited deficiency of the enzyme ADAMTS 13, responsible for cleaving large multimers of von Willebrand factor.Clinically, TTP most often affects adult women.The inclusion criteria are microangiopathic hemolytic anemia and thrombocytopenia, with or without renal failure or neurologic abnormalities.Pathology includes widespread formation of platelet thrombi with fibrin (hyaline thrombi) leading to intravascular hemolysis (thrombotic microangiopathy).