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What is Most impoant but nonspecific regulator of iron metabolism is: and explain in detail?
Ans: A. Hepcidin(Ref Robbins 91e p650 848 8/e p660)Hepcidin:Main regulator protein for iron absorption.Encoded by HAMP gene.Small circulating peptide synthesized & released from liver in response to increased intrahepatic iron levels.Proteins Involved in Iron MetabolismCeruloplasmindeg (ferrioxidase activity)DMT1degFerrireductasedeg (cytochrome b reductase I)FerritindegFerropinHeme transpoerHemojuvelinHepcidindegHephaestindegHFEdegIron-responsive element-bindingproteindegTransferrindegTransferrin receptors 1 & 2