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What is Which of the following antigen is found within the nuclei of infected hepatocytes and NOT usually in the peripheral circulation in Hepatitis B infection? and explain in detail?
HBcAg is assembled as the nucleocapsid core paicles. It is not secreted and does not circulate in blood, but can be demonstrated in hepatocytes by immunofluorescence. - HBcAg is not demonstrable in circulation because it is enclosed within the HBsAg coat. But its antibody anti-HBc appears in serum a week or two after the appearance of HBsAg. Reference : Anathanarayan & paniker's 9th edition, pg no: 544,546 <\p>