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What is Which of the following drugs acts by inhibiting DNA dependant RNA synthesis in mycobacteria? and explain in detail?
Rifampicin is a bactericidal drug which acts by inhibiting DNA dependent RNA synthesis. INH is a sulfa drug which acts by inhibition of synthesis of mycolic acid, a fatty acid component of mycobacterial cell wall. Ethambutol acts by inhibiting arabinogalactan synthesis and by interfering with mycolic acid incorporation in mycobacterial cell wall.