You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A female with recurrent aboion and isolated prolonged APTT is most likely associated with: and explain in detail?
Miscarriages are more common in women with systemic lupus erythematosus. Many of these women have antiphospholipid antibodies, which are a family of autoantibodies that bind to negatively charged phospholipids, phospholipids-binding proteins, or a combination of the two. A prolongation in the aPTT is observed that does not correct completely on mixing. Specialized testing such as the hexagonal phase phospholipid neutralization assay, the dilute Russell viper venom time, and platelet neutralization assays can confirm the presence of a lupus anticoagulant. Ref: (2010). Chapter 9. Aboion. In Cunningham F, Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (Eds), Williams Obstetrics, 23e.