You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is SCD is caused by a recessive, single-nucleotide mutation in the beta globin gene of Hgb. All of the following are TRUE about Sickle cell disease, EXCEPT: and explain in detail?
When the sickle Hgb unloads its O2, the normal conformational change exposes the valine at position 6 to the surface creating a "hydrophobic (sticky) patch". The hydrophobic patch on one deoxygenated Hgb molecule can interact with the hydrophobic patch on a second Hgb molecule, creating stiff Hgb polymers. These internal polymers cause the RBC to stiffen and adopt abnormal shapes, including a crescent or "sickle" shape that gives the disease its name. Ref: Poeus M., Mantanona T. (2012). Chapter 14. Blood. In L.W. Janson, M.E. Tischler (Eds), The Big Picture: Medical Biochemistry.