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What is Laudanosine is a metabolite of: and explain in detail?
Ans. (A) Atracurium(Ref: Miller 7th/e p880)Both atracurium and cis-atracurium are eliminated by Hoffman's elimination. Atracurium is also metabolized by liver to some extent and result in production of a metabolite, laudanosine that can cause CNS toxicity including seizures. On the other hand cis-atracurium is almost completely eliminated by Hoffman's elimination and produce negligible laudanosine.