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What is Virulence factor of the group A beta-hemolytic streptococcus is and explain in detail?
The virulence factors of group A streptococcus or Streptococcus pyogenes: 1. Capsule 2. Carbohydrate antigen 3. Protein antigen M, T, R proteins 4. Pili M protein - acts as virulence factor by inhibiting phagocytosis. Heat and acid stable but susceptible to tryptic digestion. Antibody to M proteins promote phagocytosis of cocci and is protective. Reference: Textbook of Microbiology; Anathanarayan and paniker's; 10th edition; Page no: 213