You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Alpha feto protein levels are increased in all, EXCEPT: and explain in detail?
MSAFP above normal is seen in multiple gestation, when there is placental abruption, as well as in a number of fetal abnormalities, such as neural tube defects including spina bifida and anencephaly, and abdominal wall defects. Other possibility is error in the date of the gestation. Mothers with Methylene tetrahydrofolate reductase genetic variant also have more frequent elevated MSAFP. Abnormally high levels were found infrequently in fetal distress and intra uterine fetal death. MSAFP below normal is associated with a smaller number of conditions, including Down syndrome and Trisomy 18.