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What is True about drug metabolism ? and explain in detail?
Ans. is'b'i.e., Most common enzyme involved is Cyp 3A4/5(Ref: Katzung Ilth/e p. 55)Cytochrome p450 enzymes are microsomal enzymes that are involved in phase I metabolism of many drugs.Most of the drugs are metabolized by Cyp 3A4 isoform.Cyp 3 A 4/5 carryout biotransformation of largest number (nearly 5O%) of drugs.