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What is Which of the subclass of IgG has the maximum serum concentration? and explain in detail?
IgG is the most abundant of the immunoglobulins. It has two heavy and two light chains linked by disulfide bonds. 4 subclasses of IgG are present, each differ from each other based on the amino acid sequence. Each of the 4 subclasses has unique epitopes. The subclasses of IgG are present in different amounts with IgG1>IgG2>IgG3>IgG4. IgG1 subclass has the maximum serum concentration. Ref: Infection, Resistance and Immunity By Julius P. Kreie, 2nd Edition, Page 118