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What is Nitric oxide is derived from which amino acid? and explain in detail?
Ans:D.)Arginine.NITRIC OXIDE (NO)/ENDOTHELIUM DERIVED RELAXING FACTOR (EDRF)Nitric oxide, a vasodilator is formed by the action of nitric oxide synthase on Arginine. Synthesis:NO is formed by the action of Cytosolic enzyme NO synthase in endothelial & neuronal cells.Substrate: Arginine, O 2 , NADPHCoenzyme: NADPH, FAD, FMN, Heme, tetrahydrobiopterinProduct: Citrulline, NOFeaturesReacts with oxygen & superoxide ? peroxynitrite which decomposes to form highly reactive OH-radicalIt stimulates guanyl cyclase (cGMP)FunctionsRelaxes smooth muscles Prevents platelet aggregationFunctions as neurotransmitter in brainMediates tumoricidal, bactericidal actions of macrophagesInvolved in penile erection; (sildenafil affects this process by inhibiting a cGMP dependent phosphodiesterase)