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What is Thiazide diuretics act on: and explain in detail?
Ans. B DCT mainlyDiuretic classDrugsMOASite of actionOsmotic diureticMannitolInhibit water and solute reabsorptionAll part of tubule, but mainly proximal tubuleLoop diureticsFurosemide TorsemideInhibit Na+-K+-2Cl- transportThick ascending loop of henleThiazide diureticHydrochlorothi azide Benzthiazide Chlorthalidone IndapamideInhibit Na+-Cl- co-transportDistal tubuleK+ sparing diureticSpironolactoneTriamtereneAmilorideDecrease Na+ reabsorption Decrease K+ secretionCollecting tubuleCarbonic anhydrase inhibitorAcetazolamideInhibit H+ secretion and HCO3 reabsorption, whichreduces Na+ reabsorptionProximal tubule