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What is Which is a GABA transaminase inhibitor ? and explain in detail?
Ans. is 'c' i.e., Valproate Mechanism of action Facilitation of GABA mediated C1 channel opening Barbiturates and benzodiazepines bind to GABAAreceptor and open Cl- channel. Valprote and vigabatrine inhibit enzyme GABA transaminase which degrades GABA r conc. of GABA. Tiagabine inhibits the uptake of GABA into the neurones by inhibiting GAT-1. Gabapentine enhances the GABA release from synaptic vesicles.