You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is preferred treatment after birth for baby of HBsAg positive mother? and explain in detail?
Ans. is 'b' i.e., Hep B immunoglobulin + Hep B immunization o Hepatitis B virus (HBV): It is a global public health problem. The virus is transmitted by parenteral route, sexual contact, vertical transmission and rarely through breast milk. The risk of transmission to fetus ranges from 10% in first trimester to as high as 90% in third trimester and it is specially high (90%) from those mothers who are seropositive to hepatitis B surface antigen (HBsAg) and 'e'-antigen (HBeAg).o Neonatal transmission mainly occurs at or around the time of delivery through mixing of maternal blood and genital secretions. Approximately 25% of the carrier neonate will die from cirrhosis or hepatic carcinoma, between late childhood to early adulthood. HBV is not teratogenic.Recommended treatment for infants born to HBsAg positive mother:o Infants bom to HBsAg-positive mothers should receive HBIG (0.5 mL) intramuscularly (IM) once they are physiologically stable, preferably within 12 hours after birtho HB vaccine, either plasma-derived (10 *gmg per dose) or recombinant (5 *gmg per dose), should be administered IM in three doses of 0.5 mL each.o The first dose should be given concurrently with HBIG but at a different site. If vaccine is not immediately available, the first dose can be given within 7 days after birth. The second and third doses should be given 1 month and 6 months after the first.o Testing the infant for HBsAg and its antibody (anti-HBs) is recommended at 12-15 months of age to monitor the effectiveness of therapy. If HBsAg is not detectable and anti-HBs is present, the child can be considered protected. Testing for antibody to hepatitis B core antigen (anti-HBc) is not useful, since maternal anti-HBc can persist for more than a year.o HBIG and HB vaccination do not interfere with the routine childhood immunizations.