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What is All of the following are seen in follicular carcinoma of thryoid, except: and explain in detail?
Genetics of follicular thyroid carcinomas: 30% to 50% of follicular carcinomas harbor RAS mutation. 20% to 50% of follicular carcinomas harbor PAX8-PPARG fusion. Up to 10% of follicular carcinomas exhibit gain-of-function mutations of PIK3CA (the gene that encodes phosphoinositide 3-kinase ) or loss-of-function mutations of PTEN, a tumor suppressor gene and negative regulator of PI3K pathway. Point mutations of TP53, beta-catenin (CTNNB1), and TE are seen in poorly differentiated and anaplastic carcinomas.