You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The first biologic agent approved by US FDA for the treatment of psoriasis is: and explain in detail?
In 2003, Alefacept became the first biological agent to be licensed for the treatment of severe psoriasis. Alefacept is a T-cell inhibitor - binds to CD-2 Infliximab, Etanercept- are TNF-a inhibitor Efalizumab is a T-cell inhibitor binds to CD-11