You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Concomitant use of valproic acid and lamotrigine increases the risk of : and explain in detail?
Stevens-Johnson syndrome Concomitant use of valproic acid and lamotrigine increases the plasma level of lamotrigine and increases the risk of Stevens-Johnson syndrome; hence, lamotrigine should be staed as a low dose with gradual escalation.