You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 40-year-old diabetic female presented with complaints of fatigue, abdominal distension, pruritis, anorexia, myalgia and skin rashes. On examination, icterus, hepatosplenomegaly and ascites were noted. Lab finidngs - elevated SGOT/SGPT levels, IgG levels and ANA titres, hypoalbuminemia, prolonged PT, normocytic normochromic coombs positive hemolytic anemia. A liver biopsy was conducted and HPE examination was done. All of the following antibodies are seen in the above condition except: - and explain in detail?
This is a case of Autoimmune hepatitis in background of other autoimmune disorders like DM, AIHA etc. HPE image shows a focus of lobular hepatitis with prominent plasma cells typical for this disease. Antibodies seen in AIH are: - ANA ANTI- SMA ANTI LKM 1 ANTI LC 1 pANCA SLA ANTI LKM 2 Ab is seen in drug induced hepatitis.