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What is A patient presented with colon type diarrhea with blood. On sigmoidoscopy, cauliflower mass found and excised. On genetic analysis of mass, which does not have prognostic calue? and explain in detail?
in gastric carcinoma ,.E cadherin gene mutation in diffuse cancers * Mutation in APC gene for b-catenin in intestinal , cancers - 50% - * Inactivation tumour supsamines, lead pressor gene p53 in 30% * Loss of heterozygosity in the BCL2 gene, an inhibitor of apoptosis (intestinal - distal type) cancers * HNPCC - Carries 5-10% * H. pylori infection, chronic risk of gastric cancer gastritis* Li Fraumen syndrome * Pernicious anaemia * Blood group A * Intestinal metaplasia * First degree relative carries * FAP - 10 folds more risk of gastric cancer * Mutation of H-ras oncogene and over expression of c-erb B2 gene ref:SRB&;s manual of surgery ,ed 3,pg no779