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What is What is not given in fructose intolerance patient: and explain in detail?
Ans. (c) FructoseRef: Harper's Biochemistry, 30 edn. pg. 205th* Hereditary fructose intolerance (HFI) is an inborn error of fructose metabolism caused by a deficiency of the enzyme aldolase-B.* In the deficiency of Aldolase B enzyme, if fructose is ingested, it will lead to an accumulation of fructose-1- phosphate. This accumulation has downstream effects on gluconeogenesis and regeneration of ATP.* Symptoms of HFI include: Vomiting, hypoglycemia, jaundice, hemorrhage, hepatomegaly, hyperuricemia and potentially kidney failure.* The key identifying feature of HFI: Appearance of symptoms with the introduction of fructose to the diet.* Sucrose, sorbitol should also be restricted in diet.