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What is Which of the following drug can decrease the size of prostate? and explain in detail?
In BPH, urinary obstruction is present because of increased size of prostate(static component). This is increased by spasm of urethra(dynamic component).To dilate urethra; alpha 1A receptor blockers like tamsulosin and silodosin are used. These provide the immediate symptomatic relief by treating the dynamic component.To decrease the size of prostate, 5 alpha reductase inhibitors are used which inhibit the conversion of testosterone to DHT(dihydrotestosterone). Drugs are dutasteride and finasteride. These drugs are given for long duration.