You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Mesalamine is used in: and explain in detail?
Ref: Katzung 11th p.I087Explanation:Mesalamine is an aminosalicylate used in the treatment of inflammatory bowel diseasesDrugs that contain 5-aminosalicylic acid (5-ASA) have been used successfully for decades in the treatment of inflammatory bowel diseases. 5- ASA differs from salicylic acid only by the addition of an amino group at the 5 (meta) position.Aminosalicylates are believed to work topically (not systemically) in areas of diseased gastrointestinal mucosa. Up to 80% of unformulated, aqueous 5-ASA is absorbed from the small intestine and does not reach the distal small bowel or colon in appreciable quantities.To overcome the rapid absorption of 5-ASA from the proximal small intestine, a number of formulations have been designed to deliver 5- ASA to various distal segments of the small bowel or the colon. These include sulfasalazine, olsalazine, balsalazide, and various forms of mesalamine.Pentasa is a mesalamine formulation that contains timed-release microgranules that release 5-ASA throughout the small intestineAsacol has 5-ASA coated in a pH-sensitive resin that dissolves at pH 7 (the pH of the distal ileum and proximal colon).Lialda also uses a pH-dependent resin that encases a multimatrix core.On dissolution of the pH-sensitive resin in the colon, water slowly penetrates its hydrophilic and lipophilic core. leading to slow release of mesalamine throughout the colon.