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What is Purpose of giving Glycopyrrolate before GA and explain in detail?
Glycopyrolate in preanesthetic medication: Glycopyrolate unlike atropine and scopolamine, it is a quaternary ammonium compound, it doesn't crosses the blood brain barrier. It's role: To decrease salivary, tracheobronchial secretions. It can be use IV/IM It's anti-sialogue activity is best when given at 0.004mg/kg BW IM 30-60 minutes prior peak effects. Tachycardiac effects of glycopyrrolate are minimize when given IM. Decrease the gastric secretion and increases PH of gastric content. To counteract parasympathetic overdrive, dose: 0.1 IV, repeat every 3-5 minute. To counteract parasympathetic effect, atropine is preferred due to much faster onset.