You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which one of the following biochemical parameters is most sensitive to detect open Spina bifida ? and explain in detail?
Spina bifida is defined as a defect in the neural arch ,which results in exposure of the contents of the neural canal.This cause exposure of acetyl cholinesterase which can be detected in the amniotic fluid. Refer page no 487 of Text book of obstetrics ,sheila balakrishnan 2nd edition.