You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following enzymes does the neutrophil use to initiate the production of toxic oxygen compounds that kill bacteria? and explain in detail?
The first step in killing bacteria is the production of superoxide ion, O2- , by the action of NADPH oxidase on NADPH and O2. The superoxide is then conveed to hydrogen peroxide, either spontaneously or through the action of superoxide dismutase. The hydrogen peroxide can also be conveed to the toxic HOCl. radical by the action of myeloperoxidase. Note: Hydrogen peroxide is not an enzyme. Myeloperoxidase is pa of the killing pathway, but is active later in the sequence, when H2O2 is conveed in the presence of Cl- to the HOCl. radical. Superoxide is not an enzyme. Ref: Gallin J.I. (2012). Chapter 60. Disorders of Granulocytes and Monocytes. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.