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What is All are true about splenic marginal zone lymphoma, EXCEPT: and explain in detail?
Splenic Marginal Zone Lymphoma This tumor originates in the marginal zone of the spleen white pulp (Tumor of small lymphocytes) Splenic hilar nodes are involved The circulating tumor cells are called villous lymphocytes The cells express surface immunoglobulin and CD20 The median age of patients is fifties Patients present with incidental splenomegaly and lymphocytosis in the peripheral blood Autoimmune anemia / thrombocytopenia present The clinical course of disease is indolent Long remissions after splenectomy Ref: Harrison, E-18, e-21.