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What is Which of the following is not conveed into an active metabolite? and explain in detail?
prodrugs are conveed into active metabolites all ACE inhibitors except captopril and lisinopril are prodrugs lisinopril: It is the lysine derivative of enalaprilat: does not require hydrolysis to become an active ACE inhibitor. Fluoxetine has an active demethylated metabolite Diazepam has an active metabolite Desmethyl-diazepam, oxazepam Cyclophosphamide have active metabolite Aldophosphamide, .phosphorarmide mustard, acrolein Ref ;KD Tripathi pharmacology 7th edition (page no; 503,461,22,23)