You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is true about pathophysiology of skeletal fluorosis? and explain in detail?
Fluorosis: Excessive deposition of fluorine occurs in bone and soft tissues. Fluorine stimulates osteoblastic activityand fluoroappatite crystals are laid down in bone which are resistant to osteoclastic resorption. This leads to calcium retention, impaired mineralization and secondary hyperparathyroidism. Interosseousmembrane ossification is a diagnostic radiological finding in skeletal fluorosis The characteristic pathology involves Sub-periosteal new bone formation, Osteosclerosis(Most commonly seen veebrae, ribs and pelvis) Hyperostosis at the bony attachments of ligaments, tendons and fascia.