You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following receptor gene has the ability to control TSH secretion? and explain in detail?
The THRB gene has two promoters that lead to the production of TR beta 1 and TR bete 2. TR beta 1 is ubiquitous, whereas TR beta 2 has a highly restricted pattern of expression. Mutations in THRB cause the syndrome of resistance to thyroid hormone. TR beta 1 has a specific role in liver metabolism (including the hypocholesterolemic effect of T3). Role of TR beta 2 is in the negative feedback by T3 on hypothalamic TRH and pituitary TSH. TR beta 2 also is impoant in the development of cones in the retina and in inner ear development. Ref: Brent G.A., Koenig R.J. (2011). Chapter 39. Thyroid and Anti-Thyroid Drugs. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.