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What is Fetal rhabdomyoma and explain in detail?
Rhabdomyoma is a benign mesenchymal tumor of skeletal muscle, separated into two major categories based on site: Cardiac and extracardiac. They are further separated by histology: fetal (myxoid and cellular), juvenile (intermediate), and adult types. Genital types are recognized, but are often part of either the fetal or juvenile types. The fetal type is thought to recapitulate immature skeletal muscle at about week six to ten of gestational development.

Signs and symptoms
Most fetal rhabdomyomas are tumors that develop in the head and neck or in the genital region. There are a number of cases which have been seen in association with Gorlin syndrome. However, cardiac myxomas are known to be associated with tuberous sclerosis.

Pathophysiology
Gross pathology
The tumor may be seen within the subcutaneous tissues (below the skin), mucosal surfaces or in soft tissue. Within the head and neck, the posterior ear region, skin of the face, and the tongue are the most commonly affected sites (about a 2:1 ratio of soft tissue to mucosa). The tumors are well defined, non-specific usually solitary masses, but when seen in the head and neck (or genital region), they may be polypoid. Tumors range in dimension from a few millimeters up to 12.5 cm, with a mean of about 3.0 cm. Although there are isolated case reports, multifocality is very rare.

Microscopic pathology
Fetal rhabdomyoma are separated into two histologic types: Myxoid and cellular. However, irrespective of histologic type, these tumors almost never show necrosis or increased mitoses. However, a cambium layer, abnormal mitoses and nuclear pleomorphism is not seen.
Cellular fetal rhabdomyomas are composed of bland, primitive spindled cells. The spindle cells are haphazardly arranged primitive, elongated skeletal muscle cells. The cells are set within a well-developed fibromyxoid stroma. A different pattern (intermediate type) is predominantly composed of cells with better differentiation towards skeletal muscle. There are often large ganglion cell-like rhabdomyoblasts showing prominent nucleoli within nuclei that show vesicular chromatin distribution. Another population includes strap-like rhabdomyoblasts with darkly staining pink cytoplasm. Nearly all tumors show short to more sweeping fascicles of spindled rhabdomyoblasts. The tumor cells may infiltrate into adjacent skeletal muscle or fat