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What is Pharmacokinetics is: and explain in detail?
Pharmacokinetics (Greek: Kinesis-movement)- What the body does to the drug. This refers to the movement of the drug and alteration of the drug by the body; includes absorption, distribution, binding/localization/storage, biotransformation and excretion of the drug. For example: paracetamol is rapidly and almost completely absorbed orally attaining peak blood levels at 30- 60 min; 25% bound to plasma proteins, widely and almost uniformly distributed in the body (volume of distribution - IL/kg); extensively metabolized in the liver, primarily by glucuronide and sulfate conjugation into inactive metabolites which are excreted in urine; has a plasma half-life (t1/2 )o 2-3 hours and a clearance value of 5 ml/kg/min. Ref- KD Tripathi Pharmacology 8th/e p1