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What is Imiquimod is used in treatment of anogenital was acts mainly as:- and explain in detail?
Topical immunomodulation with imiquimod 5% cream is used for treatment of: genital was superficial basal cell carcinoma actinic keratoses Acts on Toll-like receptor 7 (TLR-7). This is a cell surface receptor found on cells of monocyte lineage. Interaction of TLR-7 with ligands activates a signalling pathway, leading to release of large amounts of interferon-a, IL-12, TNF-a and other potent cytokines. S/E: irritation, discomfo and occasionally erosion at the point of application with a small risk of causing vitiligo-like depigmentation.