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What is Mechanism of action of Oseltamivir and Zanamivir is:- and explain in detail?
Oseltamivir acts by inhibiting influenza virus neuraminidase enzyme which is needed for release of progeny virions from the infected cell. Other neuraminidase inhibitor includes Zanamivir & Peramivir. These are used against Flu Virus (Bird flu/swine Flu). Drugs like Amantadine and Rimantadine are viral uncoating inhibitors. Route of administration of neuraminidase inhibitors in influenza: Zanamivir: Inhalational Oseltamivir: Oral Peramivir: Intravenous