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What is CIN III progresses to carcinoma in how many % of cases: and explain in detail?
CIN: Cervical intraepithelial neoplasia-part or whole of thickness of cervical squamous epithelium is replaced by cell of varying degress of atypia
CIN: Microinvasive carcinoma- invasive carcinoma cervix (over several years)

Mostly asymptomatic, diagnosed by routine screening done yearly after a women become sexually active. If 3 consecutive smears normal in a low risk woman do once in 3 years
CIN I-Abnormality in lower 1/3rd of epithelium
CIN II-Abnormality in lower 2/3rd of epithelium
CIN III-Abnormality in >2/3rd of epithelium

High risk factor--­

Age <18 yr at initiation of coitus
Multiple sex partners, husband with multiple parteners
HPV infection
High oncogenic risk-type 16, 18, 31, 45, 56
Low oncogenic risk-type 6, 11
CMV, HSV II infection
Smoking
Poor socioeconomic status
Aneuploid lesion
Oral contraceptive use.