You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is All are associated with MEN-2 except: and explain in detail?
Type (Chromosomal Location) Tumors (Estimated Penetrance) Gene and Most Frequently Mutated Codons MEN 1 (11q13) Parathyroid adenoma (90%) Enteropancreatic tumor (30-70%) Gastrinoma (>50%) Insulinoma (10-30% Nonfunctioning and PPoma (20-55%) Glucagonoma (<3%) VIPoma (<1%) Pituitary adenoma (15-50%) Prolactinoma (60%) Somatotrophinoma (25%) Coicotropinoma (<5%) Nonfunctioning (<5%) Associated tumors Adrenal coical tumor (20-70%) Pheochromocytoma (<1%) Bronchopulmonary NET (2%) Thymic NET (2%) Gastric NET (10%) Lipomas (>33%) Angiofibromas (58%) Collagenomas (70%) Meningiomas (8%) MEN 1 83/84, 4-bp del ([?]4%) 119, 3-bp del ([?]3%) 209-211, 4-bp del ([?]8%) 418, 3-bp del ([?]4%) 514-516, del or ins ([?]7%) Intro 4 ss ([?]10%) MEN 2 (10 cen-10q 11.2) MEN 2A MTC (90%)Pheochromocytoma (>50%) Parathyroid adenoma (10-25%) RET 634, e.g., Cys - Arg (~85%) MTC only MTC (100%) RET 618, missense (>50%) MEN 2B (also known as MEN 3) MTC (>90%) Pheochromocytoma (>50%) Associated abnormalities (40-50%) Mucosal neuromas Marfanoid habitus Medullated corneal nerve fibers Megacolon RET 918, Met - Thr (>95%) MEN 4 (12p 13) Parathyroid adenoma Pituitary adenoma Reproductive organ tumors (e.g., testicular cancer, neuroendocrine cervical carcinoma)? Adrenal + renal tumors CDKN 1B; no common mutations identified to date