You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following relaxes mesangial cells in glomerulus? and explain in detail?
Stellate cells called mesangial cells are located between the basal lamina and the endothelium. They are similar to cells called pericytes, which are found in the walls of capillaries elsewhere in the body. Mesangial cells are especially common between two neighboring capillaries, and in these locations, the basal membrane forms a sheath shared by both capillaries. The mesangial cells are contractile and play a role in the regulation of glomerular filtration. Mesangial cells secrete the extracellular matrix, take up immune complexes, and are involved in the progression of glomerular disease. TABLE 38-3Agents causing contraction or relaxation of mesangial cells. Contraction: Endothelins,Angiotensin II,Vasopressin,Norepinephrine,Platelet-activating factor,Platelet-derived growth factor,Thromboxane A2,PGF2,Leukotrienes C4 and D4,Histamine. Relaxation: Dopamine,A NP,PGE2,cAMPRef: Ganong&;s review of medical physiology,23rd edition, page no: 640, 646