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What is Alcohol causes hypoglycemia due to ? and explain in detail?
Ans. is 'a' i.e., Decreased gluconeogenesisExcess intake of alcohol leads to excessive production of NADH with a concomitant decrease in NAD+.This causes following metabolic alterations :-i) The increase availability of NADH ours the reduction of pyruvate to lactate and oxaloacetate to malate and decreasing its availability for gluconeogenesis and decrease synthesis of glucose. This results in Hypoglycemia.ii) Increased ratio of NADH/Nad+ inhibits p-oxidation of fatty acids and citric acid cycle and promotes lipogenesis, triacylglycerol synthesis and cholesterol synthesis from acetyl CoA.iii) Increased lactic acid production causes lactic acidosis and hyperuricemia.iv) Accumulation of lipid in various tissues causes fatty liver, fatty myocardium etc.