You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Mutations in type I collagen fibres results is: and explain in detail?
(Osteogenesis imperfecta) (268-M) (153-Apley's 8th)* Osteogenesis imperfecta (Brittle bones) is one of the commonest of the genetic disorders of bone.* Abnormal synthesis and structural defects of type I collagen results in abnormalities of bones teeth, ligaments, sclerae and skin.Clinical features are1. Osteopenia2. Liability to fracture3. Laxity of ligaments4. Blue colouration of the sclerae5. Dentinogenesis imperfecta ("Grumbling teeth")