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What is Danazol has which of the following actions ? and explain in detail?
Ans. is 'd' i.e., All the above Danazole It has weak androgenic, anabolic and progestational activity. The most prominent action is suppression of gonadotropin (FSH/LH) from pitutary in both men and women - inhibition of testicular/ovarian function. Uses are : Endometriosis (major use) Fibrocystic breast disease Infeility Menorrhagia Hereditary angioneuretic edema Side effects are complete amenorrhoea, androgenic effects (acne, hirusitism, decreased breast size, deepening of voice, edema, weight gain), loss of libido in men, hot flushes in women, night sweats and muscle cramp. Liver enzyme may be raised.