You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Alpha1 antitrypsin gene is on which chromosome? and explain in detail?
d. Chr 14(Ref: Nelson 20/e p 1941, 2053)a1-Antitrypsin deficiencyIt is caused by mutation in SERPINA1 gene (chr 14q), which has autosomal recessive inheritance.a1-Antitrypsin, a protease inhibitor synthesized by liver, protects lung tissue from destruction by neutrophil elastase;Most common allele of protease inhibitor (Pi) system is M & the normal phenotype is PiMM.