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What is Etanercept is a disease-modifying drug used in management of rheumatoid ahritis. What is its mechanism of action? and explain in detail?
Ans: A. Inhibition of TNF alpha Gilman 12/e p182; KDT7/e p883, 6/ep205).Etanercept:Fusion protein produced by recombinant DNA.It fuses the TNF receptor to the constant end of the IgG1 antibody.It reduces the effect of naturally present TNF.Hence a TNF inhibitor, functioning as a decoy receptor that binds to TNF.