You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A couple, with a family history of beta thalassemia major in a distant relative, has come for counseling. The husband has HbA2 of 4.8% and the wife has HbA2 of 2.3%. The risk of having a child with beta thalassemia major is: and explain in detail?
- Normal percentage of HbA2 ranges from 1.5 to 3%. - In thalassemia trait (b thalassemia minor), HbA2 level may be elevated (3.5-7.5%). - Thus, wife in this question has normal genotype (b,b) whereas husband has thalassemia - trait (b+,b). - b-Thalassemia is an autosomal recessive disease. So, None of the offsprings will have thalassemia major (b+ b+), risk of having a child with thalassemia major is 0%. 50% of the offspring (b+,b) will be carriers like father.