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What is Aldosterone regulates extracellular volume and potassium homeostasis by binding to its receptors present in all, EXCEPT: and explain in detail?
Aldosterone regulates extracellular volume and potassium homeostasis by binding to renal coical collecting duct principal epithelial cell mineralocoicoid receptors. The mineralocoicoid receptor -- a member of the nuclear receptor family and also found in the hea, colon, and hippocampus -- is localized to the cytoplasm prior to activation, undergoes a conformational change on binding to aldosterone, and translocates into the nucleus where it functions as a transcription factor. Aldosterone is rapidly inactivated to tetrahydroaldosterone in the liver. Ref: Young, Jr W.F. (2011). Chapter 10. Endocrine Hypeension. In D.G. Gardner, D. Shoback (Eds), Greenspan's Basic & Clinical Endocrinology, 9e.