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What is Which of the following hormones will be affected most after the change in sex hormone binding globulin? and explain in detail?
Ans: A. Testosterone(Ref Ganong 25/e p 422, 24/e p424; Harper 30/e p 516. 517)Testosterone binds to SHBG with higher affinity than does estradiol.Hence SHBG level change a Greater change in free testosterone level than in free estradiol.Sex hormone binding globulin:Glycoprotein binding sex steroids with high affinity as.Order:DHT>Testosterone>>Esterone/ estradiol. Due to higher SHBG affinity for DHT & Testosterone, SHBG variation has profound effects on androgens levels.