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What is Metoclopramide acts to achieve which of the following and explain in detail?
PROKINETIC DRUGS Metoclopramide Mech of action on GIT:- Metoclopramide has more prominent effect on upper g.i.t.; increases gastric peristalsis while relaxing the pylorus and the first pa of duodenum - speeds gastric emptying.This action is independent of vagal innervation, but is stronger when vagus is intact. Lower esophageal sphincter (LES) tone is increased and gastroesophageal reflux is opposed. It also increases intestinal peristalsis to some extent, but has no significant action on colonic motility and gastric secretion. Ref:- kd tripathi; pg num:-664