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What is Which of the following antitumor agents works by impairing de novo purine synthesis? and explain in detail?
Among the given antitumor drugs, methotrexate which is folic acid analog act as a folate antagonist that inhibit the conversion of (DHFA)Dihydro folic acid to tetra hydrofolic acid (THFA). We know that follic acid is utilized in de novo synthesis. Where as 5-fluorouracil act as pyrimidine antagonist by inhibiting the conversion of deoxyuridine acid to deoxythymidylic acid. And Allopurinol act by inhibiting uric acid synthesis. ESSENTIALS OF MEDICAL PHARMACOLOGY-SEVENTH EDITION -K.D TRIPATHI Page:864,862,216