You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Why is Glucose-6-phosphate is not acted upon by Glucose-6-phosphatase enzyme in cytoplasm, even if glycogen synthesis and breakdown takes place in the same cell, having an enzymes present in cytoplasm. and explain in detail?
Glycogen synthesis as well as breakdown both occurs in cytoplasm But the last step of breakdown of glycogen in liver i.e. glucose -6-phosphate to glucose formation occurs in endoplasmic reticulum and not in cytoplasm, as glucose-6-phosphatase is present in the membrane of endoplasmic reticulum.