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What is True about ester local anesthetics are all, EXCEPT: and explain in detail?
The ester and amide local anesthetics differ in their chemical stability, locus of biotransformation, and allergic potential. Amides are extremely stable, whereas esters are relatively unstable in solution. Aminoesters are hydrolyzed in plasma by cholinesterase enzymes, but the amides undergo enzymatic degradation in the liver Ref: Miller's anesthesia-7th ed, Chapter 30.