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What is A diabetic patient presented with uncontrolled blood sugar level. He has history of pancreatitis and family history of urinary bladder carcinoma. He does not want to take injectable drugs. Which of the following drug can be added to control his blood sugar? and explain in detail?
Linaglutide(-ide) is a peptide, so not given orally. It is a GLP 1(incretin) analogue and it can cause pancreatitis.Sitagliptin is a DPP 4(dipeptidyl peptidase 4) inhibitor; can cause pancreatitis.Pioglitazone(PPAR- gamma agonist) can cause urinary bladder carcinoma; so can't be given.So, canagliflozin (SGLT 2 inhibitor) can be added.