You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which among the following is a long acting beta-2 agonist? and explain in detail?
The long-acting inhaled 2 agonists (LABA) salmeterol have proved to be a significant advance in asthma and COPD therapy. This drugs have a bronchodilator action of >12 hours and also protect against bronchoconstriction for a similar period. Albuterol is a sho acting selective 2 receptor agonist with pharmacological propeies and therapeutic indications similar to those of terbutaline. It is administered either by inhalation or orally for the symptomatic relief of bronchospasm. Pirbuterol is a sho acting and relatively selective 2 agonist. Its structure is identical to albuterol except for the substitution of a pyridine ring for the benzene ring. Pirbuterol acetate is available for inhalation therapy; dosing is typically every 4-6 hours. Pirbuterol is the only preparation available in a breath-activated meter-dose inhaler, a device meant to optimize medication delivery by releasing a spray of medication only on the patient's initiation of inspiration. Orciprenaline is a sho acting 2 adrenergic agonist.It is considered to be 2-selective, although it probably is less selective than albuterol or terbutaline and hence is more prone to cause cardiac stimulation. Ref: Westfall T.C., Westfall D.P. (2011). Chapter 12. Adrenergic Agonists and Antagonists. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.