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What is The form of THF used in treatment is : and explain in detail?
N5 Formyl THFA/ Folinic acid has high stability so it is used therapeutically. Extra reading : N5 Formyl THFA/ Folinic Acid (5-formyl tetrahydrofolic acid or leucovorin) is necessary co-factor in the body (an essential B vitamin). Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. Uses : 1. to counteract the toxic effects of folic acid antagonists, such as methotrexate (inhibits DHFR) 2. in the treatment of megaloblastic anemias due to folic acid deficiency