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What is In apoptosis, cytochrome C acts through and explain in detail?
Cytochrome c leaks into the cytosol, where it binds to APAF-1 andactivates caspase-9. Like caspase-8 of the extrinsic pathway, caspase-9 can cleave and activate the executioner caspases. The integrity of the mitochondrial outer membrane is regulated by pro-apoptotic and anti-apoptotic members of the BCL2 family of proteins( Robbins Basic Pathology, 9 th edition)