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What is Which is gametocidal for all species: and explain in detail?
Ans: C. PrimaquineRef: Goodman Gilman's The Pharmacological Basis of Therapeutics 13" edn; Page no. 980, NVBD GuidelinesDrugsActionChloroquineSchizontocidal for all speciesGametocidal for PV, PO and PMNo action on hypnozoitesQuininePrimary blood schizontocidalLittle effect on sporozoiteGametocidal to PV and PMAemisinin groupBlood schizontocidal Gametocidal action recently describedMefloquineStrong schizontocidal action against all speciesGametocidal against PV, PM and POSporonticidal actHalofantrineSchizontocidal to all speciesNo action on latent tissue form of PV and gametocytesAtovaquoneBlood schizontocidal (Used primarily for MDR PF)PyronaridineSchizontocidal for PF, PV and MDR PFSulfadoxine -PyrimethamineActive against blood schizonts of PF. Less active against other speciesPrimaquineDestroys late hepatic stage and latent forms of PV and POGametocidal to all species, mainly PF.No action on erythrocyte stage of PF, though activeProguanilWeak schizontocidal action against all species.