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What is Progressive multifocal leukoencephalopathy spares and explain in detail?
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease which results from the reactivation of John Cunningham virus (JC virus) infecting oligodendrocytes(which provide suppo and insulation to axons in CNS) The term Leukoencephalopathy refers to all of the brain white matter diseases Toxic leukoencephalopathy or toxicspongiform leukoencephalopathy is a rare condition that is characterized by progressive damage (-pathy) to white matter (-leuko-) in the brain (-encephalo-), paicularly myelin, due to causes such as exposure to drug abuse, environmental toxins, or chemotherapeutic drugs