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What is Which one of the following variants of papillary carcinoma thyroid occurs in younger individuals including children with lymphonodal metastases in almost all cases and morphologically simulates Hashimoto thyroiditis is: and explain in detail?
Ans. (c) Diffuse sclerosing variant(Ref: Robbins 9th/pg 1097-1098)Diffuse sclerosing variant of papillary carcinoma*It occurs in younger individuals, including children.*The tumor has a prominent papillary growth pattern intermixed with solid areas containing nests of squamous metaplasia.*There is extensive, diffuse fibrosis throughout the thyroid gland, often associated with a prominent lymphocytic infiltrate, simulating Hashimoto thyroiditis.*Lymph node metastases are present in almost all cases.*Diffuse sclerosing variant carcinomas lack BRAF mutations, but RET/PTC translocations are found in approximately half the cases.