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What is In Peutz-Jeghers syndrome, polyps are mainly seen in: and explain in detail?
In Peutz-Jeghers syndrome, polyps are mainly seen in Jejunum Peutz-Jeghers syndrome Autosomal dominant disorder Most common in small intestine- Jejunum Germ line loss of function mutations in LKB1/STK11 gene are present May occur in stomach, colon & with much lower frequency in bladder and lungs Multiple gastrointestinal hamaomatous polyps + Mucocutaneous hyperpigmentation Gross- Polyps are large & pedunculated with lobulated contour Histologic findings : characterized by proliferation of the muscularis mucosae to form branching configurations covered by hyperophic, but otherwise normal mucosa