You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The mechanism of the development of Acute Rheumatic Fever is which of the following? and explain in detail?
Acute rheumatic fever results from immune response to group A streptococci (Strep. pyogenes) which cross-reacts with host tissues. The antibodies directed against the M proteins of streptococci cross react with the self antigens in the hea. In addition, CD4+ T cells specific for streptococcal peptides also react with self proteins in the hea and produce macrophage activating cytokines. So, the damage to the hea tissue is a combination of antibody and T-cell mediated reactions