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What is All are true about bisphosphonates except : and explain in detail?
Ans. C. Absorption increases with foodBisphosphonates(BPNs):BPNs are analogies of pyrophosphate; carbon atom replacing orygen in the P-O-P skeletonAll oral BNPs are poorly absorbed and produce gastric irritation as major side effect.They inhibits bone resorption and have recently attracted considerable attention because of their ability to prevent osteoporosis in addition to their usefulness in metabolic bone diseases and hypercalcemia.MOA: Localize to regions of bone resorption & exe their greatest effects on osteoclasts.Food reduces absorption even fuher, necessitating their administration on an empty stomach.Nearly half of the absorbed drug accumulates in bone; the remainder is excreted unchanged in the urine.Decreased renal function, esophageal motility disorders & peptic ulcer disease are the main contraindications.