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What is Thyroid peroxidase is not involved in and explain in detail?
Inorganic iodine enters the body primarily as iodide, I-. After entering the thyroid follicle (or thyroid follicular cell) a Na+/I-sympoer (NIS) on the basolateral side, iodide is shuttled across the apical membrane into the colloid pendrin, after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or iodinium (I+).The "organification of iodine," the incorporation of iodine into thyroglobulin for the production of thyroid hormone, is nonspecific; that is, there is no TPO-bound intermediate, but iodination occurs reactive iodine species released from TPO.The chemical reactions catalyzed by thyroid peroxidase occur on the outer apical membrane surface and are mediated by hydrogen peroxide.Ref: DM Vasudevan, 7th edition, page no: 673