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What is All of the following are true about Sickle cell disease, Except: and explain in detail?
C i.e. 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residueIn sickle cell anemia- Glutamic acid is replaced by valine at sixth position in /3 - globin chainQ.Sticky patch is generated as a result of replacement of polar residue (negatively charged glutamate amino acid) with a nonpolar hydrophobic residue (valine)Q. This change makes HbS (sickle cell hemoglobin) less soluble, when deoxygenated and cause sicklingQ.HbS confers resistance against malaria in heterozygotesQ.