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What is A Histopathological examination of an excision specimen from a lesion on the dorsal surface of pensi reveals a papillary lesion with clear vacuolization of epithelial cells on the surface and extension of the hyperplastic epithelium into the underlying tissue. What could be the possible diagnosis? and explain in detail?
Clear vacuolization of the superficial layers of epithelial cells is called Koilocytosis.
Koilocytosis is characteristic of HPV infection. HPV causes both condyloma accuminatum and verrucous carcinoma. But condyloma accuminatum is benign condition, hyperplastic epithelium does not extend into the underlying tissue.