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What is All are actions of coisol on the skin and connective tissue except and explain in detail?
It is antiproliferative for fibroblasts and keratinocytes. Glucocoicoids in excess inhibit fibroblasts, lead to loss of collagen and connective tissue, and thus result in thinning of the skin, easy bruising, stria formation, and poor wound healing. Hyperpigmentation is a direct effect of ACTH on melanocoin 1 receptors.