You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following statements about Wilson's disease is TRUE? and explain in detail?
In Wilsons disease, due to deficiency of ATP7B protein, biliary copper excretion is impaired and it accumulates in the liver. Defective copper incorporation into ceruloplasmin leads to its excess catabolism and lower ceruloplasmin levels. Serum copper levels are usually lower than normal because of low blood ceruloplasmin. As the disease progresses, free copper levels increase and is deposited in various organs and is excreted in the urine. Ref: Harrison's principles of internal medicine 18th edition/ chapter 360.