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What is Which of the following is true about sickle cells? and explain in detail?
- Sickle cell disease is a common familial hemolytic anemia caused by a point mutation in b-globin in which glutamic acid is replaced by valine at 6th position. - It promotes the polymerization of deoxygenated hemoglobin, leading to red cell distoion, hemolytic anemia, microvascular obstruction, and ischemic tissue damage. - This sickling is reversible with oxygenation. - Sickling is severe in homozygous state than heterozygous state. - HbS facilitates sickling, not HbF - Dehydration & deoxygenation facilitates sickling