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What is Mechanism of action of Abciximab? and explain in detail?
Ans. a (Inhibitor of GPIIb/IIIa) (Ref. KDT 6th/pg. 610)Inhibitors of GPIIb/IIIa receptors on plateletsABCIXIMAB(o humanized monoclonal antibody directed against the IIb/IIIa complex)# Tirofiban# Eptifibatide# AbciximabMechanismMonoclonal antibody that binds to the glycoprotein receptor IIb/IIIa on activated platelets, preventing aggregation.Clinical useAcute coronary syndromes, Percutaneous transluminal coronary angioplasty.ToxicityBleeding, Thrombocytopenia DrugMechanism of actionTirofiban & EptifibatideSpecific GpIIb/IIIa receptor inhibitionClopidogrelADP-induced platelet aggregation inhibition by irreversibly Dlocking P2Y12FondaparinuxInhibition of factor XaDabigatranOral thrombin inhibitionAtfimeprasePlasmin-independent fibrinolysis