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What is Drug of choice of typhoid - and explain in detail?
Ans. is 'd' i.e., Ciprofloxacin o The older agents used for the treatment of typhoid were;ChloramphenicolAmpicilinTrimethoprim Sulfamethoxazoleo These drugs are not used nowdays because o f widespread resistance.o Nowdays the drug of choice for Typhoid all over the world is a "Fluroquinolone" (Ciprofloxacin, ofloxacin).An important point to remembero High level of fluoroquinolone resistance (ciprofloxacin) have been reported from India and other parts of South East Asia in S, paratyphi and S.typhi infection.# Nalidixic acid resistant S.typhi (NARST) have decreased ciprofloxacin sensitivity-1 and are less effectively- treated with fluoroquinolones.# The fluroquinolones should not be used as first line treatment for typhoid fevers in patients from India and other parts of South Asia with high rates offluroquinolone resistance unless antibiotic susceptibility data demonstrates fluoroquinolone or nalidixic acid sensitivity>.Alternative drugs for patients with fluoroquinolone resistance are : -o Beta lactam Parenteral - Ceftriaxone Oral - Cefiximeo Azithromycino ChloramphenicolAntibiotic Therapy for Enteric Fever in AdultsIndicationAgentEmpirical treatmento Ceftriaxoneo AzithromycinFully susceptibleo Ciprofloxacinb (first line)o Amoxicillin (Second line)o Chloramphenicolo Trimethoprim-sulfamethoxazoleMutlidrng-Resistanto Ciprofloxacino Ceftriaxoneo AzithromycinNalidixic Acid-Resistanto Ceftriaxoneo Azithromycino High-dose ciprofloxacin