You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The earliest phenotypic manifestation of idiopathic hereditary hemochromatosis is and explain in detail?
Hemochromatosis is a common inherited disorder of iron metabolism in which dysregulation of intestinal iron absorption results in deposition of excessive amounts of iron in parenchymal cells with eventual tissue damage and impaired function in a wide range of organs. When the diagnosis of hemochromatosis is established, it is impoant to counsel and screen other family members.Asymptomatic and symptomatic family members with the disease usually have an increased saturation of transferrin and an increased serum ferritin concentration. These changes occur even before the iron stores are greatly increasedA fasting serum transferrin saturation greater than 50% is abnormal and suggests homozygosity for hemochromatosis.Ref: Harrison's 19/e p2516