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What is Pendred's syndrome is due to a defect in and explain in detail?
Pendred disease is an autosomal recessive disorder leading to congenital bilateral sensorineural hearing loss and goitre with euthyroid or mild hypothyroidism. It has been linked to mutations in the PDS gene, which codes for the pendrin protein. The gene is located on the long arm of chromosome 7 (7q) Ref : Dhingra 7e pg 130.