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What is A 5 year old child suffering from nephrotic syndrome is responding well to steroid therapy. What would be the most likely finding on light microscopy: and explain in detail?
Light microscopy in minimal change disease shows no significant abnormality. Electron microscopy shows obliteration of epithelial cell footprocess. Immunofluorescence shows absence of immunoglobulin or complement deposition. Ref: Kliegman, Behrman, Jenson, Stanton (2008), Chapter 537, "Nephrotic syndrome", In the book, "NELSON TEXTBOOK OF PEDIATRICS", Volume 2, 18th Edition, New Delhi, Pages 2192-93 ; O P Ghai Essential Pediatrics, 6th Edition, Page 451