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What is Intracanalicular hepatic apparatus is affected by-a) Alagille syndromeb) Cystic fibrosisc) Congential hepatic fibrosisd) Caroli diseasee) Polycystic liver disease and explain in detail?
A heterogenous group of lesions causing altered architechture of intrahepatic billiary tree. They are :
	Von Meyenburg complexes  
	Congenital hepatic fibrosis
	Polycystic liver disease
	Caroli disease
Alagille syndrome is absence of portal tract, bile duct peculiar facies, vertebral anomalies and CVS defects.
In cystic fibrosis — bile canaliculi are plugged by mucinous material when longstanding, can cause biliary cirrhosis. It cause ductular proliferation and portal inflammation.