You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Drugs that can be used in kernicterus- and explain in detail?
Ans. is 'a' i.e., Barbiturate Treatment of hyperbilirubinemia o The following are the treatment options for treatment of hyperbilirubinemia. A) Drugs (Pharmacological therapy) B) Phototherapy C) Exchange transfusion Pharmacological therapy Following drugs are used in hyperbilirubinemia ? 1) Barbiturates (Phenobarbitone) It is effective only if given to mother before delivery. It acts by inducing the conjugation of bilirubin --> Phenobarbitone is an enzyme inducer. 2) Metalloporphyrins (Tin-Sn & Zinc-Zn) o These compounds decrease the formation of bilirubin by inhibiting heme oxygenase. 3) Miscellaneous o Frequent milk feeding Prevents reabsorption of unconjugated bilirubin from intestine by reducing enterohepatic circulation. Charcol & agar --> These are bilirubin binding agents which prevent bilirubin reabsorption from gut.