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What is Esmolol and explain in detail?
Esmolol, sold under the brand name Brevibloc, is a cardio selective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.
It is a class II antiarrhythmic. Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart and other organs of the body.  Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.It was patented in 1980 and approved for medical use in 1987.

Medical uses
To terminate supraventricular tachycardia,
Episodic atrial fibrillation or flutter,
Arrhythmia during anaesthesia,
To reduce HR and BP during and after cardiac surgery, and
In early treatment of myocardial infarction.
Esmolol is also used in blunting the hemodynamic response to laryngoscopy and intubation.

Dosing
A loading dose of 0.5 mg/kg is given followed
by 0.05–0.2 mg/kg/min infusion.

Metabolism
Esmolol is considered a soft drug, one that is rapidly metabolized to an inactive form.  Esmolol is rapidly metabolized by hydrolysis of the ester linkage, chiefly by the esterases in the cytosol of red blood cells and not by plasma cholinesterases or red cell membrane acetylcholinesterase