You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is a procoagulation protein ? and explain in detail?
Ans. is 'd' i.e., Thrombin Coagulation Cascade o Coagulation cascade is a series of enzymatic conversions, turning inactive proenzymes into activated enzymes and culminating the formation of thrombin. o Thrombin then conves the soluble protein fibrinogen precursor into insoluble fibrous protein fibrin. o The blood coagulation pathway are divided into. 1.Extrinsic --> Activated by tissue factor. 2.Intrinsic --> Activated by factor XII (Hagmen factor). o In vivo coagulation is predominantly occurs extrinsic pathway. o Clotting is regulated by three types of natural anticoagulants. Antithrombin III --> Binds to heparin like molecule on endothelial surface and this complex inhibit factor II (thrombin), IX, X, XI, XIL Protein 'C' & 'S' --> These are Vit K dependent proteins. Thrombomodulin bind to thrombin and this complex activates protein 'C', which then, with the help of protein `S' as a cofactor, inactivates factor V & VIII. Tissue factor pathway --> Secreted by endothelium and inactivates tissue factor VII & factor X. inhibitor ( TFPI)