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What is RBC transketolase deficiency is seen in and explain in detail?
(A) Thiamine deficiency# TRANSKETOLASE is an enzyme of both the pentose phosphate pathway.> Transketolase activity is decreased in deficiency of thiamine, which in general is due to malnutrition. Two diseases are associated with thiamine deficiency: beriberi and Wernicke-Korsakoff syndrome.> Red blood cell transketolase activity is used in the diagnosis of Wernicke's encephalopathy and other B1-deficiency syndromes if the diagnosis is in doubt.