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What is In ARDS which is damaged? and explain in detail?
In ARDS,alveolar capillary endothelial cells & type 1 pneumocytes(alveolar epithelial cells) are damaged/injured,leading to the loss of the normally tight alveolar barrier to fluid and macromolecules.As a result,edema fluid rich in protein accumulates in the interstitial & alveolar spaces.Condensed plasma proteins aggregate in the air spaces with cellular debris and dysfunctional pulmonary surfactant to form hyaline membrane whorls. Reference:Harrison's Medicine-20th edition,page no:2032