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What is Defect in collagen formation is seen in and explain in detail?
Scurvy is caused due ti deficiecy of ascorbc acid. Ascorbic acid is necessary for the post-transltional hydroxylation of proline and lysine residues. Hyroxyproline and hydrolysine are essential for the formation of crosslinks in the collagen, which gives the tensile strength to the fibers. This process is absolutely necessary for the normal production of suppoing tissues such as osteiod, collagen and intercellular cement substance of capillaries. REFERENCE: DM VASUDEVAN SEVENTH EDITION ; PAGE NO:497