You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is General paralysis of insane is associated with ? and explain in detail?
Ans, A. NeurosyphillisGeneral paresis, also known as general paralysis ofthe insane or paralytic dementia, is a severe neuropsychiatric disorder, classified as an organic mental disorder and caused by the chronic meningoencephalitis that leads to cerebral atrophy in late-stagesyphilis.Degenerative changes are associated primarily with the frontal and temporal lobar coex-General paralysis of the Insane (GPI) is progressive deterioration of the whole mental and physical personality.Symptoms included exaggeratedkneejerk, Iack ofreaction ofthe pupils to light, an inabilityto pay attention, a'clouding'of consciousness, poor sho-term memory, tremulous voice, reflex disturbances, and retinal anomalies' and diminished skin sensation.Patients were often recognizable by their striking 'delusions of grandeur"