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What is E cadherin gene deficiency is seen in and explain in detail?
Ref Robbins 9/e p291 Cadherins is derived from the calcium dependant adherence protein.It paicipate in interactions between cells of same type.The linkage of cadherins with the cytoskeleton occurs through the catenins.The cell to cell interactions mediated by cadherins and catenins play a major role in regulating cell motility, proliferation,and differentiation and account for the inhibition of cell proliferation that occurs when cultured normal cells contact each other ( contact inhibition) Reduced functions of E cadherins is associated with ceain types of breast and gastric cancer