You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is 1st line Anti tuberculous drug contraindicated in pregnancy? and explain in detail?
Ans. is 'd' i.e., Streptomycin Treatment of tuberculosis in Pregnanacy* Work up and treatment of tuberculosis should not be delayed in Pregnant women. All pregnant women with active tuberculosis should be treated immediately because the risk to the mother and fetus is 1.6 much higher from maternal tuberculosis than it is from potential harm from the anti-tubercular drugs.* First line drugs can be safely used in pregnancy except streptomycin which is contraindicated because of its associated with fetal ototoxicity.* Second line drugs are not recommended in pregnancy (They are used only if benefit outweighs the risk, as in case of MDR tuberculosis).* Pyrazinamide is not recommended by CDC (USA) in absence of sufficient safety data, however many tubercular authorities all over world support its use.* CDC recommends an alternative 9 month regimen containing isoniazid and rifampin throughout (supplemented by ethambutol, until drug susceptibility results are available).* Breastfeeding is not contraindicated in women using antituberculosis drugs.