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What is Mechanism of action of Triazoles:- and explain in detail?
The azoles act by inhibiting fungal cytochrome P450 enzyme 'lanosterol 14-demethylase' and thus impair ergosterol synthesis. These are presently the most extensively used antifungal drugs. Mechanism of action of other antifungal drugs: Polyene (Amphotericin B/Nystatin): Binds to ergosterol and creates pores. 5 Flucytosine : DNA polymerase inhibitor. Allylamine (Terbinafine, Butenafine, Naftifine): Inhibit enzyme squalene epoxidase. Griseofulvin : Act mitotic spindle Echinocandin (Caspofungin): Inhibit Beta 1-3