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What is True about Pralidoxime ? and explain in detail?
Ans. is 'a' i.e., It acts by regenerating acetylcholinesterase enzyme Pralidoxime (and other oximes) acts by reactivating cholinesterase enzyme. Oximes are used for poisoning with organophosphate insectide not for chlorinated insectisides (chlorinate hydrocarbons e.g. DDT, lindane, dieldrin). Some of the war gases are organophosphate compounds e.g. dialkylfuorophosphate, for which oximes can be used. RBC cholinesterase levels reflect enzyme activity better than plasma cholinesterase because: i) Plasma cholinesterase can give falsly high activity if there is RBC hemolysis (RBC cholinesterase comes into plasma) ii) In chornic organophosphate exposure, plasma cholinesterase may return to normal but RBC levels remains depressed.