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What is Tyrosine enters gluconeogenesis by forming which substrate? and explain in detail?
GLUCONEOGENESIS 1. Definition - It is the process by which glucose molecules are produced from non-carbohydrate precursors. These include lactate, glucogenic amino acids (Alanine, glutamic acid, aspaic acid, etc), glycerol pa of fat and propionyl CoA derived from odd chain fatty acids. 2. Site - Gluconeogenesis occurs mainly in the liver, and to a lesser extent in the renal coex. The pathway is paly mitochondrial and paly cytoplasmic. 3. Key Gluconeogenic Enzymes Pyruvate carboxylase Phosphoenol pyruvate carboxy kinase Fructose-1-6-bisphosphatase Glucose-6-phosphatase . The amino acids like phenyl alanine, tyrosine, aspeate,aspargin (Glucogenic amino acids) 1st conve into Fumerate then enters into gluconeogenesis. Ref: DM VASUDEVAN TEXTBOOK OF BIOCHEMISTRY,EIGHTH EDITION,PG.NO.,135,136.