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What is A 45-year-old man has hypeension. A thiazide diuretic agent had been prescribed with continued elevated blood pressure. The inclusion of spironolactone to the thiazide diuretic is done to achieve wof and explain in detail?
Potassium sparing diuretics Spironolactone,eplerenone and amiloride but not triamterene themselves lower BP slightly. However, they are used only in conjunction with a thiazide diuretic to prevent K+ loss and to augment the anti- hypeensive action. Spironolactone side effects Include gynaecomastia, impotence, menstrual irregularities. This problem has been offset in the newer aldosterone antagonist eplerenone. Ref:- kd tripathi; pg num:-561