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What is Which is a finding in lymphoid tissues in individuals with common variable hypogammaglobulinemia? and explain in detail?
Common Variable Immunodeficiency Near Normal number of B cells in blood & LN Unable to differentiate to plasma cells Intrinsic B cell defects - defective CK receptor BAFF Also abnormal T cell regulation of B cells Both sexes equally; manifest in childhood or adolescence Presents as Recurrent sinopulmonary pyogenic infections Recurrent herpes V infection Persistent diarrhoea by G Lamblia RA Lymphoid malignancy