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What is Pyrimidine overproduction results in all except and explain in detail?
Defective enzyme of pyrimidine metabolism Signs and symptoms Dihydropyrimidine dehydrogenase Can develop toxicity to 5-fluorouracil, also a substrate for this dehydrogenase Orotate phosphoribosyl transferase and orotidylic acid decarboxylase Orotic acid aciduria type 1, megaloblastic anemia Orotidylic acid decarboxylase Orotic acid aciduria type 2 Pyrimidine overproduction is not the causal factor in Reye's syndrome. Reye's syndrome results in secondary pyrimidine overproduction. Reference: Harpers illustrated biochemistry 30th edition