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What is CIN III progresses to carcinoma in how many % of cases and explain in detail?
CIN: Cervical intraepithelial neoplasia-pa or whole of the thickness of cervical squamous epithelium is replaced by the cell of varying degrees of atypiaCIN: Microinvasive carcinoma- invasive carcinoma cervix (over several years)Mostly asymptomatic, diagnosed by routine screening done yearly after women become sexually active. If 3 consecutive smears normal in a low risk woman do once in 3 yearsCIN I-Abnormality in lower 1/3rd of epitheliumCIN II-Abnormality in lower 2/3rd of epitheliumCIN III-Abnormality in >2/3rd of epitheliumHigh-risk factor--Age <18 yr at the initiation of coitusMultiple sex paners, the husband with multiple panersHPV infectionHigh oncogenic risk-type 16, 18, 31, 45, 56Low oncogenic risk-type 6, 11CMV, HSV II infectionSmokingPoor socioeconomic statusAneuploid lesionOral contraceptive use.