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What is A boy after playing football complaining fatigue and abdominal pain. He also had a history of hand swelling in past. On ultrasonography, he has shrunken spleen. What is the likely diagnosis of this patient? and explain in detail?
Sickle cell anemia b-globin hemoglobinopathy(mutation in coding sequence ofb-globin gene, GAG - GTG ) Anemia and reticulocytotic;sickle-shaped erythrocytesdemonstrable on peripheral blood smear; homozygosity forhemoglobin Sdemonstrable by electrophoresis Characterized bysevere anemia, recurrent painful and aplastic crises, and nonhealing leg ulcers; recurrent splenic infarcts with progressive fibrosisresult inauto splenectomy