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What is Post-anesthetic nausea and vomiting is uncommon with: and explain in detail?
Ans. (a) PropofolSalient Features of Propofol* It is a milky white powder that is preservative free. Therefore, it must be used within 6 hours.* It is an oil based preparation, therefore injection is painful.* Onset of action: 15 seconds* Duration of action: 5-10 min. (due to redistribution)* Due to rapid action, post anesthetic nausea and vomiting is uncommon with propofol* It possesses very strong antiemetic and antipruritic action.* It decreases blood pressure and impairs baroreceptor reflexes.* It produces more severe and prolonged respiratory depression than thiopentone.* It has no muscle relaxant property.* It has cerebroprotective activity but does not possess anticonvulsant activity. Rather, myoclonic jerking and muscle twitching can be seen with the use of propofol.* It is the intravenous anaesthetic of choice for day care surgery.* It is also the intravenous anaesthetic of choice for sedation in ICU.* Propofol is the intravenous anaesthetic of choice in the patients with malignant hyperthermia.* Along with opioids (alfentanil or fentanyl) propofol is the agent of choice for total intravenous anaesthesia (TIVA).