You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Maintainence dose is calculated by using value of? and explain in detail?
Ans. is 'a' i.e., Clearance Drug dosing For drugs with longer t1/2 a dose that is sufficient to attain the target concentration after single administration, if repeated will accumulate according to plateau principal and produce toxicity later on. On the other hand, if the dosing is such as to attain target level at steady state, the therapeutic effect will be delayed by about 5 half lives and this lapse of time may be undesirable some time. Such drugs are often administered by initial loading dose and subsequent maintenance doses. Loading dose