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What is Hormone sensitive lipase is not activated by- and explain in detail?
Hormone Sensitive Lipase is a catabolic enzyme (enzyme which breaks down the Triglycerides of Adipose tissue). As this enzyme belongs to a Catabolic pathway. So it is inhibited by insulin . As insulin activates all anabolic pathway enzymes. Rest all hormones like Glucagon, Thyroid, Epinephrine activates hormone sensitive lipase enzyme. Extra Edge: Hormone Anabolic pathway Catabolic pathway Insulin Activate All i.e. HMP Glycogenesis FA synthesis Cholesterol synthesis TG synthesis Lipoprotein Lipase enzyme Glycolysis & Link reaction Only (Exceptions) Glucagon Activates None Activate all i.e. Glycogenolysis Beta oxidation of Fatty Acids, Gluconeogenesis Ketone body synthesis Ketone body utilization, Except above two(Glycolysis & Link reaction)