You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Malignant hyperthermia is caused by all except and explain in detail?
(A) Thiopentone sodium # MALIGNANT HYPERTHERMIA is the clinical syndrome observed during GA associated with rapidly increasing temperature as great as 1degC/5 minute.> Etiology: It is due to abnormality of Ryanodine receptor which is a calcium releasing channel of sacroplasmic reticulum. Causative agents of malignant hyperthermia> Muscle relaxant: Succinylcholine> Inhalational agents: Halothane (most common); Isoflurane; Enflurane; Desflurane; Methoxyflurane> Local anaesthetics: Lignocaine> Tricyclic antidepressants MAO inhibitors; Phenothiazines> Clinical features of malignant hyperthermia: Hyperthermia (T > 1 09degF); Increased end tidal CO2; Tachycardia, hypertension; Severe metabolic acidosis; Hyperkalaemia, increased creatine phosphokinase; Renal failure; DIC.> Treatment of Malignant Hyperthermia: Stop all anaesthetics; Control temperature; Sodium bicarbonate IV 2-4 meq/kg; Dantrolene 2 mg/kg repeated at every 5 minutes.> There is a fall in intraocular pressure with isoflurane, and isoflurane may precipitate malignant hyperpyrexia.> Halothane classically produces malignant hyperpyrexia in susceptible individuals. There is a reduction in intraocular pressure.