You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following condition shows epiphyseal dysgenesis as a pathognomonic feature? and explain in detail?
The diagnosis of congenital hypothyroidism is by testing a sample of blood is taken from the heel or from the umbilical cord at bih and analyzed for total T4 or TSH. A total T4 of less than 6 g/dL or a TSH more than 25 mU/L is usually indicative of congenital hypothyroidism. A low total T4 alone may be associated with low circulating thyroxine-binding globulin (TBG), but the significantly elevated TSH is diagnostic of primary hypothyroidism. The diagnosis may be accompanied by radiologic evidence of retarded bone age or epiphyseal dysgenesis (centers of ossification, especially of the hip, may show multiple small centers or a single stippled, porous, or fragmented center) in severe congenital hypothyroidism. Ref: Styne D. (2011). Chapter 6. Growth. In D.G. Gardner, D. Shoback (Eds), Greenspan's Basic & Clinical Endocrinology, 9e.