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What is Metabolism of a drug primarily results in: and explain in detail?
* Major aim of metabolism (Biotransformation) is to conve lipid-soluble (non-polar) drugs to water soluble (polar) drugs. * In the absence of metabolism, body will not be able to get rid of lipophilic substances, and they will become very long acting. * Biotransformation of drugs may lead to any of the following 1. Inactivation of an active drug 2. Conversion of active drug to its active metabolite 3. Activation of inactive drug (prodrug)