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What is Glucose intolerance is seen with all except and explain in detail?
Refer kDT 6/e p274 Several antihypeensive drugs have an adverse effect on glucose tolerance that may paially or completely negate the beneficial effects of reducing blood pressure as it relates to the incidence of coronary hea disease and its complications. Diuretics (paicularly high doses) and beta-blockers without intrinsic sympathomimetic activity have the greatest adverse effect on glucose intolerance. Central alpha-agonists, angiotensin-conveing enzyme inhibitors, calcium channel blockers, and alpha-blockers do not adversely affect glucose and are preferred in diabetic hypeensive patients, selected hypeensive patients at risk for developing glucose intolerance, and probably most other patients with mild essential hypeension as initial and/or monotherapy compared with diuretics and beta-blockers