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What is Drug NOT used in pulmonary hypeension ? and explain in detail?
Ans. is 'c' i.e., Alpha blockers Drug for pulmonary hypeension 1. By increasing the effect of NO/cGMP o This can done by increasing the concentration of cGMP by preventing its degradation. o This can be achieved by inhibiting phosphodiesterase-5 by phosphodiesterase -5 inhibitors like sildenafil, Tadalofil. 2. By increasing the effect of Prostacyclin (cAMP) o This can be achieved by using prostacyclins like epoprostenol, Treprostinil, Iloprost. 3. By decreasing the effect of endothelin o This can be acheived by using endothelin receptor antagonists like Bosentan, ambrisentan. By having direct vasodilatory effect on pulmonary vessels. o Calcium channel blockers like nifedipine dilate both systemic and pulmonary vascular bed.