You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is All of the following statements about hormone replacement therapy (H) are true except ? and explain in detail?
Ans. is 'd' i.e., It increases the risk of endometrial carcinoma Hormone replacement therapy increases the risk of MI (coronary aery disease). The increased risk is attributed to progestin component. o H restore Ca++ balance, fuher bone loss is prevented and the excess fracture risk is nullified. o There is a higher incidence of breast cancer. o Risk for endometrial carcinoma is not increased as protective effect of progestin nullify the carcinogenic effect of estrogen. o There is increased risk for gall stone and migraine. o There is a small protective effective of H on colorectal cancer. Note :? o Usually in H combination of estrogen and progestin is given (combined H), except in hysterectimized women where estrogen alone is given. o With estrogen alone there is increased risk of endometrial cancer and decrease risk of coronary aery disease (as estrogen increases HDL and decreases LDL and triglyceride level). o So for H with estrogen alone the answer of this question will change. In that case it will be option 'a' i.e., increased risk of coronary aery disease.