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What is Basic pathology in rickets- and explain in detail?
Ans. is 'b' i.e., Defect in mineralizationo To know the pathophysiology of rickets, one should know the structure of bone.o Bone consists of ?1) Protein matrix i.e. osteoid ----> also known as unmineralized bone.2) Mineral phase. principally composed of calcium and phosphate, mostly in the form of hydroxyapatite.o In rickets osteoid (protein matrix) is formed normally but mineralization of this osteoid does not occur i.e. there is defective mineralization.o Rickets is a syndrome of diverse etiology characterized by defective mineralization of bone and epiphyseal cailage (growth plate) of growing bones.