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What is Nitric oxide is synthesized from which amino acid: and explain in detail?
NO is also called as Endothelium Derived Relaxing Factor (EDRF). NO (nitric oxide) is synthesized from arginine by enzyme NOS (Nitric oxide synthase) in the endothelial cells. It requires 5 cofactors:- NADPH FAD FMN Heme and Tetrahydrobiopterin (BH4). The vasodilator - nitroglycerin also enters smooth muscle cells, where its metabolism also leads to the formation of NO. NO synthase :-There are three isoforms of NOS (Nitric oxide synthase) 1. nNOS - neuronal 2. iNOS- inducible 3. eNOS- endothelial EC no. 1 (oxido-reductase) Mono oxygenase (one oxygen is added in substrate) Usually belongs to EC no 4 but NO synthase is an exception.