You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is MOA of acetazolamide used in glaucoma: and explain in detail?
Ans. (d) Decrease aqueous productionRef: A.K. Khurana 6th ed. /451-52* ACETAZOLAMIDE is a carbonic anhydrase inhibitor which acts in OAG by decreasing aqueous production.* Carbonic anhydrase derivatives are: Acetazolamide, Dorzolamide, Brinzolamide* Dorzolamide is mildest carbonic anhydrase inhibitor, hence considered as DOC for glaucoma in children.* Alpha-2 agonist (Brimonidine, Apraclonidine) also act by decreasing aqueous production.* Class of drugs which act by increasing outflow:# | Trabecular outflow: Pilocarpine, Epinephrine# | Uveoscleral outflow: PG Analogue (Latanoprost)Must Know TREATMENT OF Glaucoma* First line DOC for ACG: Mannitol* TOC for ACG: Laser iridotomy* DOC for OAG: PG analogue (Latanoprost)* Most powerful anti glaucoma drug: Latano- prost* DOC for OAG in India- Timolol* Safest anti-glaucoma for children- Dorzolamide