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What is Extent of nicotinic receptor blockade required for neuromuscular transmission failure due to non-depolarizing neuromuscular blockers:- and explain in detail?
Non depolarising neuromuscular blocker are competitive blockers and when more than 80 -90 % receptor is blocked then only neuromuscular transmission fails. Characteristic of NDNB 1. Decreased twitch response to a simple stimulus. 2. Fade on tetanic stimulus 3. Train of four response is seen 4. TOF ratio <1 5. Post tetanic potentiation 6. Potentiation of other nondepolarising drugs Antagonism by anticholinesterase