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What is Hypereosinophilic syndrome is a disease characterized by elevated eosinophil count in the blood for at least 6 months, without any recognizable cause, with involve-ment of either hea, nervous system or bone marrow. What should be the eosinophil count for diagnosis? and explain in detail?
Ans: C. >1500/ mm3(Ref Harrison 19/e p1686, 135e-8, 18/e p481 e-21.5)Eosinophil count for hypereosinophilia syndrome diagnosis = >1.5 x 109/L (>1500/mm).Blood Eosinophilia:Neither secondary or clonal.Cause: Idiopathic.Hypereosinophilic Syndrome (HES):Subcategory of idiopathic eosinophilia with persistent increase of AEC to >1.5 x 109/L (>1500/ mm3).Features:Presence of eosinophil-mediated organ damage -Cardiomyopathy, gastroenteritis, cutaneous lesions, sinusitis, pneumonitis, neuritis & vasculitis.Also thromboembolic complications, hepatosplenomegaly & either cytopenia or cytosis.