You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A lady with secondary amenorrhea is negative for progesterone challenge test but positive for combined estrogen and progesterone challenge test. What is the probable cause:- and explain in detail?
PCOS has plenty estrogens but no progesterones, hence Progesterone therapy will elicit a withdrawal bleeding Asherman Syndrome is Endometrial Fibrosis, hence no estrogen or progesterone will show any effect In Pregnancy , if Estrogen and progesterones are given, it will not cause a withdrawal since the patient herself is making adequate amount of those hormones. Only ovarian failure or an Hypothalamic failure will be positive for combined estrogen and progesterone challenge test.