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What is True statements are all, EXCEPT: and explain in detail?
Answer is D (Class III MHC does not encode complement): Class III MIIC encode complements of the component system. Genes coding for histocompatibility antigens are clustered on a small segment of chromosome 6. This cluster constitutes the Human MHC or Human Leucocytes Antigen (HLA) complex. Class I antigens: * are expressed on all nucleated cells and platelets.Q * encode cell surface glycoproteins.Q * they are encoded by three closely related loci HLA-A, HLA-B, HLA-C.Q * CD8 + T cells widely express Class I HLA antigens.Q Class II antigens: * are expressed on macrophages, B cells and T cells.Q * encode cell surface glycoproteins.Q * they have a single loci HLA-D (with three surface loci DR, DQ, DP).Q Class III antigens: * these encode complements of the complement system.Q Note: That class III molecules loci, are present in between the loci for class I and class II molecules, on the HLA complex. Thus they lie adjacent to both class I as well as class II molecules.()