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What is Which of the following anticancer drug is excreted by lungs? and explain in detail?
Fluorourri ul U, -FU) is conveed in the body to the corresponding nucleotide 5-fluoro-2-deoxyuridine monophosphate, which inhibits thymidylate synthase and blocks the conversion of deoxyuridilic acid to deoxythymidylic acid. Metabolites are primarily excreted through the lungs as carbon dioxide. A small poion of a dose is excreted in urine as unchanged drug ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:824