You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Intractable glaucoma characteristically occurs due which one of the following? and explain in detail?
Iris melanoma usually grows very slowly along the iris surface and may invade the angle and anterior ciliary body -- intractable glaucoma. Iris melanoma makes up about 5% of uveal melanomas. In general, uveal melanomas are three times commoner in patients with blue/grey than brown irides. They are extremely rare in black people and there is no sexual predilection. Conditions associated with or predispose to early onset uveal melanomas are: a. Ocular melanocytosis b. Nevus of Ota c. Dysplastic cutaneous nevi d. Familial melanoma e. Neurofibromatosis--1 Presentation of iris melanoma is in the fifth to sixth decade, a decade earlier than ciliary body and choroidal melanoma, with enlargement of a pre-existing iris lesion. Treatment: 1. Iridectomy for small tumors 2. Iridocyclectomy for tumors invading the angle 3. Radiotherapy for non-resectable tumors 4. Enucleation for diffusely growing tumors