You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is In children, acute kidney injury in terms of urine output is defined as? and explain in detail?
Acute kidney injury (AKI) in children is defined: Increase in S. creatinine of >0.3 mg/dl over 48 hrs or Increase in S. creatinine 1.5-2 fold from baseline in last 7 days Urine output <0.5 ml/kg/hour for > 6 hours Pediatric-Modified Rifle (pRIFLE) Criteria: CRITERIA ESTIMATED Creatinine clearance (eCCl) URINE OUTPUT Risk eCCl decrease by 25% <0.5 mL/kg/hr for 8 hr Injury eCCl decrease by 50% <0.5 mL/kg/hr for 16 hr Failure eCCl decrease by 75% oreCCl <35 mL/min/1.73 m2 <0.3 mL/kg/hr for 24 hror anuric for 12 hr Loss Persistent failure >4 wk End-stage End-stage renal disease(persistent failure >3 mo) Comparison of RIFLE versus AKIN versus KDIGO criteria for AKI Criteria RIFLE Creatinine definition Criteria AKIN Creatinine definition Criteria KDIGO Creatinine definition Urine output Risk >1.5 - fold increase from baseline SCr or decrease in GFR>25% Stage 1 >0.3 mg/dL increrase or>1.5 fold increase from baseline SCr within 48 hrs Stage 1 >0.3 mg/dl increase within 48 hrs or 1.5-1.9 times baseline within 7 days <0.5 ml/kg/h for >6 hours Injury >2 fold increase from baseline SCr or decrease in GFR>50% Stage 2 >2 fold increase from baseline SCr Stage 2 2.0 - 2.9 times baseline within 7 days <0.5 mL/kg/h for 12 hours Failure >3 fold increase from baseline SCr or increase to>4 mg/dl or decrease in GFR >75% Stage 3 >3 fold increase from baseline SCr or increase to>4.0 mg/dl with an acute vincrease of >0.5 mg/dl or initiation of R Stage 3 >3 times baseline within 7 days or increase to>4.0 mg/dL with an acute increase of >0.5 mg/dL or initiation of R <0.3 mL/Kg /h for 24 hours or anuria for > 12 hours **SCr- Serum Creatinine; AKIN: Acute Kidney Injury Network; KDIGO: Kidney Disease Improving Global Outcomes