You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following ilineses increases the risk of developing tuberculosis ? and explain in detail?
Because silica is cytotoxic to alveolar macrophages,patients with silicosis are at greater risk of acquiring lung infections that involve these cells as a primary defense(Mycobacterium tuberculosis,atypical mycobacteria and fungi).Because of the increased risk of active tuberculosis,the recommended treatment of latent tuberculosis in these patients is longer.Another potential clinical complication of silicosis is autoimmune connective tissue disorders such as rheumatoid ahritis and scleroderma,as well as lung cancer. Reference:Harrison's medicine-18th edition,page no:2125.