You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Scabies oral treatment of choice: and explain in detail?
Ans. (c) IvermectinRef. KDT 6th ed. 864* Scabies is caused by an ectoparasite sarcoptes scabei. It is highly contagious. The mite burrows through the epidermis, laying eggs which form papules that itch intensely.* Most common site of entry- finger webs.* Drugs used are:# Permethrin: broad spectrum and potent insecticide, currently most efficacious. It is DOC for scabies. MOA: It causes neurological paralysis in insects by delaying depolarization. Single application needed in most cases. Very less toxicity; 100% cure rate.# Lindane: another broad spectrum insecticide. Efficacy lower than permethrin. MOA: kills lice and mites by penetrating through their chitinous cover and affecting the nervous system.# Benzyl benzoate: oily liquid with a faint aromatic smell. It is applied over face and neck after a bath. A second coat is applied next day which is washed after 24 hours.# Crotamiton# Sulfur# Ivermectin: highly effective in scabies and pediculosis as well. It is the only ORALLY administered drug which is used for scabies (ectoparasitosis) A single dose of 0.2 mg/kg has cured almost 90- 100% of population. It is contraindicated in children < 5 yrs, pregnant and lactating women.