You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The hyperkinetic features of the Huntington's disease are due to the loss of: and explain in detail?
Corpus striatum sends inhibitory input to globus pallidus (external); globus pallidus is reciprocally connected with subthalamic nucleus. In Huntington's disease there is loss of (inhibitory) GABAergic and cholinergic neurons of the striatum. Loss of dopaminergic neurons in the nigrostriatal tract will lead to Parkinson's disease. Huntington's disease is a trinucleotide repeat disorder with multiple CAG repeats.