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What is Gamma Glutamyl Transferase is increased in and explain in detail?
(A) Alcoholic hepatitis # Function of GGT:> It is involved in the transfer of amino acids across the cellular membrane and in glutathione metabolism.> Location> GGT is found in high concentrations in the liver, bile ducts and kidney.> Enzyme is also present in other tissues, such as the epididymis.> Clinical significance Congestive heart failure Cholestasis (congestion of the bile ducts) Cirrhosis of the liver Restricted blood flow to the liver Restricted venous outflow from liver like Budd-Chiari syndrome Necrosis of the liver Liver tumors Hepatitis Hepatotoxic drugs> Its levels are increased in chronic and acute alcohol abuse.