You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Maltese cross on polarized microscopy is seen in: and explain in detail?
In case of Penicillium marneffei infection, histopathologic examination of tissues and smears of blood or material from skin lesions shows oval or elliptical yeast-like organisms with central septation. Penicillium marneffei is a thermally dimorphic fungus. Infection results from the inhalation of conidia from the environment. The organism conves to the yeast phase in the lungs and then spreads hematogenously to the reticuloendothelial system. It is usually diagnosed in AIDS patients by culture of P. marneffei from blood or from biopsy samples of skin, bone marrow, or lymph node. Ref: Oxford Textbook of Medicine edited by David Alan Warrell, volume1 page 712. Kauffman C.A. (2012). Chapter 206. Superficial Mycoses and Less Common Systemic Mycoses. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.