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What is True regarding endothelin-1 are all except and explain in detail?
Endothelin 1 is a broncho constrictor that it is implicated in the pathophysiology of asthma Endothelin-1, one of the most potent vasoconstrictor agents yet isolated. Endothelins cause contraction of mesangial cells which reduce GFR Endothelin-1 appears to be primarily a paracrine regulator of vascular tone. Endothelin is a positive inotropic agent in human hea Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No:565