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What is In Ochronosis there is deficiency of which of the following enzymes? and explain in detail?
The defective enzyme in Ochronosis (Alkaptonuria) is homogentisic acid oxidase in tyrosine metabolism. Homogentisate gets oxidised by polyphenol oxidase to benzoquinone acetate which undergoes polymerization to form a pigment ALKAPTON. Alkapton gets deposited in connective tissues, bones and various organs resulting in condition called OCHRONOSIS.