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What is Increased levels of C3NeF are associated with? and explain in detail?
The term C3 glomerulopathy encompasses two conditions: dense deposit disease (formerly MPGN, type II) and C3 glomerulonephritis Pathogenesis Complement dysregulation due to acquired or hereditary abnormalities of the alternative pathway of complement activation is the underlying cause of dense deposit disease and C3 GN. Some patients have an autoantibody against C3 convease, called C3 nephritic factor (C3NeF), that causes uncontrolled cleavage of C3 by the alternative complement pathway. In other patients, mutations in various complement regulatory proteins, such as Factor H, Factor I, and membrane cofactor protein (MCP), or autoantibodies to Factor H, are the cause of unregulated activation of the alternative pathway of complement. Ref: ROBBINS BASIC PATHOLOGY 10th ed Pg no: 560