You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Ig active in type 1 hypersensitivity. and explain in detail?
Ans: b (IgE) Ref: Robbins, 7th ed, p. 205Dendritic cells + Antigen ' CD4 Helper T cells '! THL cells produce."Most of the immediate hypersensitivity reactions are mediated by IgE antibodies."Dendritic cells + Antigen - CD4 Helper T cells - THL cells produce.IL5 - stimulate Eosinophils ILA - 'Turning on' of B cellsIgE production.ILB - IgE production, mucus secretion. IgE thus produced will bind to receptors on basophils and mast cells. These cells, aimed with IgE, when re-exposed to specific allergen, leads to a series of reactions responsible for the clinical expression of type 1 hypersensitivity.The primary and secondary mediators released from mast cells are listed belowPrimary mediatorsSecondary mediatorsHistamineLeucotrienes (B4C4D4)ProteasesProstaglandins (PGD2)Chemotactic factors (C39)PAFHeparinCytokines - IL 1, 3, 4, 5, 6, TNF,GM CSF