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What is Mr. Lallu, aged 54 years, who is a known diabetic patient develops cirrhosis. There is associated skin hyperpigmentation and restrictive cardiomyopathy. which of the following is the best initial test to diagnose this case? and explain in detail?
The degree of increase in the total body-iron stores can be assessed byMeasurement of serum iron and the percent saturation of transferrin (or the unsaturated iron-binding capacity),Measurement of serum ferritin concentrationLiver biopsy with measurement of the iron concentration and calculation of the hepatic iron index, andMRI of the liverIn patients with inflammation and hepatocellular necrosis, serum ferritin levels may be elevated out of propoion to body-iron stores due to increased release from tissues.Ref: Harrison's 18/e p3165, 17/e p2433