You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A pregnant female with known cardiac disease presents to you in the first trimester with history of warfarin embryopathy what should be advised now? and explain in detail?
Ans. B. Replace warfarin with heparin in First trimesterRef: Williams Obstetrics, 24'h ed.Warf'arin has a low molecular weight and readily crosses the placenta.Exposure between the 6th and 9th weeks may result in warfarin embryopathy characterized by stippling of the veebrae and femoral epiphyses and by nasal hypoplasia with depression ofthe nasal bone.