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What is Bullous disease in which autoantibodies are formed against antigens of epidermal intercellular junctions and explain in detail?
Bulla development in pemphigus vulgaris is due to Acantholysis, this is disruption of intercellular attachment leading to intraepidermal bullae. Autoantibodies against desmosomal protein-desmoglein-3 mediate the pathogeneis.