You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Cachectin is produced by- and explain in detail?
Cachectin (Tumour necrosis factor - α) is produced by -

Macrophages
Monocytes
N.K. Cells

Biological effects of TNF-α

Tumor cytotoxicity
Induction of acute phase proteins
Lipolysis
Endotoxic shock
Fever
Antiviral and antiparasitic effect
Cachexia
Phagocytic cell activation