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What is Inhibition of protein synthesis in translocation steps occurs by and explain in detail?
Reversible Inhibitors in bacteria : These antibiotics are bacteriostatic . Tetracycline bind to the 30S subunit of bacterial ribosome and so inhibit attachment of aminoacyl tRNA to the A site of ribosomes. Chloramphenicol inhibits the peptidyl transeferase acitivity of bacterial ribosomes. Erythromycin (macrolides) and clindamycin prevent the translocation process. REFERENCE : DM.VASUDEVAN.TEXTBOOK ; SEVENTH EDITION ; PAGE NO : 605.