You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Aquaporin channel mediated through ADH and explain in detail?
Vasopressin * Vasopressin - secreted by suprachiasmatic nuclei of hypothalamus and transpoed to posterior pituitary * Biologic half life - 18 min * Vasopressin receptors:- V1A and V1B V1A and V1 B:- * G protein coupled receptor that acts phosphatidylinositol hydrolysis to increase intracellular Ca++ concentration * V1A - mediate vasoconstrictor effect * V1B - also called V3 receptors- specific to anterior pituitary - mediate secretion of ACTH V2 receptor:- * G protein coupled receptor that acts through Gs to increase cAMP * Antidiuretic action * Mechanism of action - inseion of aquaporin 2 into the apical membranes of the principal cells of collecting duct. Factors affecting vasopressin secretion Ref:- Ganong's Review of Medical Physiology 25th ed; pg num:- 696