You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Rituximab is an antibody against? and explain in detail?
ANSWER: (A) CD20 REF: Goodman and Gillman 11th edition page 901, Katzung 12th edition page no 646 Repeat Pharmacology December 2009 See APPENDIX-34 below for "FDA APPROVED MONOCLONAL ANTIBODIES" "Rituximab, sold under the trade names Rituxan and MabThera, is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells. Rituximab is used in the treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders" APPENDIX - 34 FDA Approved Monoclonal Antibodies Antibody Type Target Indication (What it's approved to treat) Abciximab chimeric Inhibition of glycoprotein Ilb/IIIa Cardiovascular disease Adalimumab human Inhibition of TNF-alpha signaling Several auto-immune disorders Alemtuzumab humanized CD52 Chronic lymphocytic leukemia Basiliximab chimeric IL-2Rc; receptor (CD25) Transplant rejection Bevacizumab humanized Vascular endothelial growth factor (VEGF) Colorectal cancer, Age-related macular degeneration (off-label) Cetuximab chimeric Epidermal growth factor receptor Colorectal cancer, Head and neck cancer Certolizumab pegol humanized Inhibition of TNF-alpha signaling Crohn's disease Daclizumab humanized IL-2Rcr receptor (CD 2 5) Transplant rejection Eculizumab humanized Complement system protein C5 Paroxysmal nocturnal hemoglobinuria Efalizumab humanized CDlla Psoriasis Gemtuzumab humanized CD33 Acute myelogenous leukemia (with calicheamicin) Ibritumomab tiuxetan murine CD20 Non-Hodgkin lymphoma (with yttrium- 90 or indium-111) Infliximab chimeric Inhibition of TNF-alpha signaling Several autoimmune disorders Muromonab-CD3 murine T cell CD3 Receptor Transplant rejection Natalizumab humanized Alpha-4 (c4) integrin, Multiple sclerosis and Crohn's disease Omalizumab humanized Immunoglobulin E (IgE) Mainly allergy-related asthma Palivizumab humanized An epitope of the RSV F protein Respiratory Syncytial Virus Panitumumab human Epidermal growth factor receptor Colorectal cancer Ranibizumab humanized Vascular endothelial growth factor A (VEGF-A) Macular degeneration Rituximab chimeric CD20 Non-Hodgkin lymphoma Tositumomab murine CD20 Non-Hodgkin lymphoma Trastuzumab humanized ErbB2 Breast cancer