You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Lipofuscin containing macrophages are a feature of? and explain in detail?
Ans is 'a' i.e., Wear and tear Lipofuscin* It is an insoluble pigment, also known as lipochrome and wear or tear or aging pigment. Lipofuscin is not injurious to the cell or its functions.* Its importance lies in being the tell-tale sign of free radical injury and lipid peroxidation.* It is seen in cells undergoing slow, regressive changes and is particularly prominent in the liver and heart of aging patients or patients with severe malnutrition and cancer cachexia.* On electron microscopy, the granules are highly electron dense, often have membranous structure in their midst and are usually in perinuclear location. In tissue section it appears as yellow brown pigment.* Deposition of lipofuscin in the heart is referred as brown atrophy.