You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following has more anti-thyroid action? and explain in detail?
Ans. (a) I131Ref: Bailey and Love Principles and Practice of Surgery, 26th edition, Page 758Methods of treating a Thyrotoxic Patient (from Bailey and Love)* Antithyroid Drugs:# Carbimazole is the DOC for preparing the patient to euthyroid state.# It is given in a dose of 10mg three times daily.# Once patient becomes euthyroid: Carbimazole is given a maintenance dose of 5mg three times daily for 6-24 months.# "Block and replacement therapy" - Another method of preparation by giving heavy dose carbimazole and making patient euthyroid and supplementing with 0.1mg thyroxine# Recurrence of thyrotoxic feature is nearly 50%* Surgery:# is around 5% and this has its own risk of surgery.* RAI:# Response is slow but substantial improvement occurs 8-12 weeks.# Two or more doses are required for 20% cases.Choice of treatment in Each case:* Diffuse toxic goiter: Initial dose of anti-thyroid drugs followed by RAI.* Toxic Nodular goiter - Surgery is best, RAI produces lesser response here* Toxic nodule - Surgery or RAI is appropriate* Recurrent thyrotoxicosis after Surgery - Radioiodine is best* Failure of Previous antithyroid drugs or RAI: Surgery is best