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What is Burkholderia cepacia is intrinsically resistant to: and explain in detail?
Burkholderia cepacia complex strains are intrinsically resistant to a wide range of antimicrobial agents including Aminoglycosides, Polymyxin, First and Second generation cephalosporins and Carboxypenicillins. TMP-SMX, Meropenem and Doxycycline are the most effective agents in vitro and may be staed as first-line agents. Burkholderia cepacia: Gram Negative, rod-shaped, motile bacteria with obligate aerobic characteristic) Recognized as an antibiotic-resistant nosocomial pathogen in ICU patients Cause of the &;Cepacia syndrome&; in CF patient (Rapidly fatal syndrome of respiratory distress and septicemia) Intrinsically Resistant B.cepacia complex strains are intrinsically resistant to a wide range of anti microbial agents Susceptible Antimicrobial agents that are effective agianst B.cepacia complex in vitro include Aminoglycosides Polymyxins (Polymyxin B) First and Second generation of Cephalosporins Carbocypenicillins Trimethoprim-Suplhamethoxazole (Co-trimaxazole) Carbapenems (Meropenem) Cephalosporins (Third generation e.g., Ceftazidime) Ureidopenicillins Fluroquinolones Doxycycline or Minocycline Chloramphenicol Ref: Harrison&;s ; Ananthanarayana 10th edition/156