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What is Which of the following Anti-retro viral agent can cause bone marrow suppression? and explain in detail?
ZIDOVUDINE: Is a NI (NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR) against HIV-1, HIV-2 and HTLVs I and II. It causes Competitive inhibition but no impact on cells already infected with HIV . It causes Bone Marrow Suppression, Lipodystrophy, Erythrocytic Macrocytosis, Skeletal muscle myopathy, Hepatic toxicity and on chronic use can cause Nail hyperpigmentation