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What is In glycolysis, the first committed step is catalyzed by and explain in detail?
Glucose enters glycolysis by phosphorylation to glucose 6-phosphate, catalyzed by hexokinase, using ATP as the phosphate donor. Under physiological conditions, the phosphorylation of glucose to glucose-6-phosphate can be regarded as irreversible. Hexokinase is inhibited allosterically by its product, glucose-6-phosphate. Reference: Harper; 30th edition; Page no: 169