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What is A hypeensive patient presented with open-angle glaucoma. Drug of choice is to decrease the IOP is: and explain in detail?
Timolol is a potent, non-selective beta receptor antagonist. It has no intrinsic sympathomimetic or membrane-stabilizing activity. It is used for hypeension, congestive hea failure, acute MI, and migraine prophylaxis. It is used in the treatment of open-angle glaucoma and intraocular hypeension. Its mechanism of action in treating open angle glaucoma is not precisely known; but the drug appears to reduce aqueous humour production through blockade of beta receptors on the ciliary epithelium. Ref: Westfall T.C., Westfall D.P. (2011). Chapter 12. Adrenergic Agonists and Antagonists. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.