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What is Fusion inhibitor is- and explain in detail?
Ans. is 'a' i.e., Enfuvirtide New drugs in HIV infection o Etravirine is recently approved NNRTI. This is the second generation NNRTI and is effective against HIV resistant to first generation NNRTI (Efavirenz, Delavirdine. Nevirapine). Fusion inhibitors (Entry inhibitors) o Enfuvirtide binds to Gp41 subunit of HIV envelop protein and inhibits the fusion of viral and host cell membrane. o Maraviroc is a CCR5 Co-receptor antagonist and is only active against "CCR - 5 - tropic virus" which tends to predominate early in infection. Integrase inhibitors o Raltegravir and Elvitegravir act by inhibiting enzyme integrase.