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What is A diabetic female on INH and rifampicin for TB developed DVT.She was staed on warfarin, PT is not raised, and next step should be: and explain in detail?
Rifampicin is a microsomal enzyme inducer and hence enhances the metabolism of warfarin. Hence warfarin can be replaced with a LMWH as the treatment is to stop warfarin. Acenocoumarin is a coumarin derivative similar to warfarin. From medical pharmacology padmaja 4th edition Page no 339,340