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What is Antibiotic potentiating the effect of NM blocker? and explain in detail?
Ans. is 'b' i.e., Aminoglycoside Impoant interactions of skeletal muscle relaxants General anaesthetics potentiate competitive blockers in the following order : Isoflurane (most), sevoflurane, desflurane, enflurane, Holothane and nitrous oxide (least). . Anticholinesterase (neostigmine, pyridostigmine & edrophonium) reverse the action of competitive blockers, they can enhance depolarizing neuromuscular blockers. Calcium channel blockers (verapamil) potentiate both competitive and depolarizing neuromuscular blockers. Diuretics produce hypokalemia which enhances competitive block. Diazepam, propranolol and quinidine intensify competitive block. Aminoglycosides, tetracycline, polypeptide antibiotics, clindamycin and lincomycin can potentiate competitive block. High doses of glucocoicoids reduce the effect of competitive blockers