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What is All of the following statements are true with relation to anesthesia and obesity except? and explain in detail?
General pharmacokinetic principles dictates, with ceain exceptions that drug dosing should take into consideration the volume of distribution for administration of the loading dose, and the clearance for the maintenance dose. A drug that is mainly distributed to lean-tissues should have the loading dose calculated on the basis of LBW. If the drug is equally distributed between adipose and lean tissues, dosing should be calculated on the basis of TBW. For maintenance, a drug with similar clearance values in both obese and non-obese individual should have the maintenance dose according to LBW. However the drug whose clearances increase with obesity should have maintenance dose calculated according to TBW.