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What is Auditory toxicity is maximum with: and explain in detail?
AMIKACIN: It is a semisynthetic derivative of kanamycin tc which it resembles in pharmacokinetics, dose anc toxicity. The outstanding feature of amikacin is its resistance to bacterial aminoglycoside inactvating enzymes. Thus, it has the widest spectrurr of activity, including many organisms resistan: to other aminoglycosides. However, relatiwh higher doses are needed for Pseudomonas, Prot c. ....