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What is Langerhans cells in skin fall under which category and explain in detail?
Langerhans Cell (LC) * Bone marrow-derived dendritic cell with monocyte-macrophage lineage found in stratum spinosum; constitutes 3-5% of cells of epidermis; contains actin and vimentin * Critical in recognizing and presenting foreign antigens to specific T lymphocytes . * Connected to keratinocytes E-cadherin receptors . * On EM, Langerhans cell with folded nucleus and distinct intracytoplasmic organelles (Birbeck granules: striated appearance with either rod-shape and/or tennis-racquet-shape). * Exposure to UV radiation causes depletion of LCs and decreases ability to present antigen. Ref:- Dermatology by sima Jain; pg num:- 9