You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is 50 year old male with positive family history of prostate cancer has come to you for a screening test. Which is the most sensitive screening test to pickup prostate cancer ? and explain in detail?
The combination of digital rectal examination and PSA levels are the most sensitive screening test to pick up prostate cancer. Diagnosis of prostate cancer is based on symptoms, an abnormal DRE, a change or an elevated serum PSA levels. Ref: Harrison's Principles Of Internal Medicine, 16th Edition, PAge 544, 545/ 18th edition chapter 95; Current Surgical Diagnosis and treatment, By Gerard M Dohey, 12th Edition, Page1045, 46