You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Anti TB drug causing optic neuritis: and explain in detail?
Ref: KDT 6th ed. pg. 742* Side effect of Ethambutol: Loss of visual acuity/colour vision, field defects due to optic neuritis is the most important dose and duration of therapy dependent toxicity.* Important side effects of antitubercular drugs:* Peripheral neuropathy (due to vit B6 deficiency): ISONIAZID* Orange color urine-RIFAMPICIN* Flu-like symptoms- RIFAMPICIN* Hyperuricemia/gout- PYRAZINAMIDE* Optic neuritis- ETHAMBUTOL* Nephrotoxic, Ototoxic, Neuromuscular Junction Blocker- STREPTOMYCINOther important points to remember about Anti TB drugs:* First line anti TB drugs are: HRZE (Isoniazid, Rifampicin, Pyrazinamide, Ethambutol)* All first line drugs are bactericidal EXCEPT- Ethambutol (it is bacteriostatic)* Most hepatotoxic ATT-Pyrazinamide* 1st line ATT with exclusive intracellular action-Pyrazinamide* 1st line ATT with exclusive extracellular action-Streptomycin* Which anti TB drugs are NOT hepatotoxic-Ethambutol and Streptomycin.* It should not be used in children below 6 years of age because these young patients may not be able to report visual impairment.