You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A genetic disorder renders fructose 1,6 bisphosphatase in liver less sensitive to regulation by fructose 2,6- bisphosphate. All of the following metabolic changes occur EXCEPT: and explain in detail?
Note that question is asking about the wrong statement. as shown in flow cha below, The level of fructose 1,6 bisphosphate is lower than normal not higher in case of mutation. so option a is wrong. Explanation: Normally Fructose 2, 6 bisphosphate is the inhibitor of Fructose 1,6 bisphosphatase (an enzyme of gluconeogenesis). So, it decreases the activity of Fructose 1,6 bisphosphatase. Thus increases the rate of glycolysis. BUT now due to mutation, activity of Fructose 1,6 bisphosphatase is not decreased. So, Fructose 1,6 bisphosphatase will increase. So its substrate (Fructose 1, 6 bisphosphate ) is decreased. This is committed molecule of glycolysis. So glycolysis decreases. Therefore, ATP & Pyruvate decreases.