You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 60-year-old man presents with a 6-month history of increasing fatigue. Physical examination reveals marked pallor, and a CBC shows a macrocytic anemia. Which of the following is the most likely cause of anemia in this patient? and explain in detail?
- Macrocytic anemia can be caused by folate & Vit B12 deficiency. - Conditions associated with their deficiency are: Malnutrition - Alcoholics, vegans etc Decreased intrinsic factor, pancreatic & ileal diseases. Fish tape worm infection. Blind loop syndrome Increased requirement like children, pregnancy, lactation etc Drugs like methotrexate, OCP etc -Interfere with Folate metabolism - As the question states an elderly man with malnutrition, most appropriate cause of macrocytic anemia is chronic alcoholism. - Remaining options - Chronic diseases, iron deficiency & renal diseases may present with microcytic anemia not macrocytic.