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What is Follicle stimulating hormone (FSH) receptors are present on: and explain in detail?
FSH receptor is a specific G-protein coupled receptor. It is present in granulosa cells (ovary) and Seoli cells (testis). cAMP is the second messenger; it stimulates production of CREB-P and CREM-P (transcription factors that initiate expression of target genes). FSH stimulation of granulosa cells produces estradiol; stimulation of Seoli cells produces inhibin. Theca cells (ovaries) and Leydig cells (testis) have receptors for LH. Both FSH and LH downregulate their receptors.