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What is In primary pulmonary hypeension basic abnormality in gene lies in and explain in detail?
Bone morphogenetic protein receptor II Mutation in the bone morphogenetic protein receptor-2 (BMPR-II) cause pulmonary aerial hypeension. The BMPR-II gene plays a role in regulating the number of cells in ceain tissues. Researchers suggest that a mutation in this gene promotes cell division or prevents cell death, resulting in an overgrowth of cells in small aeries throughout the lungs. As a result, these aeries narrow in diameter which increases the resistance to blood flow. The blood pressure in the pulmonary aery and the right ventricle of the hea increases to overcome the increased resistance to blood flow resulting in pulmonary hypeension.