You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A middle-aged male presented with history of fatigue and tiredness. On investigating, he had a hemoglobin of 8g/dL and MCV of 110 fl with the peripheral smear showing macrocytes and hypersegmented neutrophils. Which of the following is the most likely cause of the findings in this patient? and explain in detail?
Ancylostoma duodenale (hookworm) infestation and colon cancer can be associated with chronic blood loss leading to iron deficiency (microcytic hypochromic anemia). Chronic renal failure can lead to anemia of chronic inflammation which usually presents with normocytic normochromic anemia. Chronic alcoholism can be associated with folic acid deficiency which causes megaloblastic anemia (macrocytosis, elevated MCV, hypersegmented neutrophils).