You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A patient presents with Endocrinopathy, fibrous dysplasia of bone and hyperpigmentation. Diagnosis is? and explain in detail?
Ans. (a) McCune Albright syndrome(Ref: Robbins 9th/pg 1206-1207)McCune-Albright syndromeGeneticsIt is due to GNAS mutation - continuous activation of stimulatory G proteinPatho physiologyIncreased production of hormones by glands regulated by the G protein systemClinical featuresPrecocious puberty, Polyostotic fibrous dysplasia, unilateral Cafe au lait spots