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What is Woman of30 years with Raynaud's phenomenon, polyarthritis, dysphagia of 5-years and mild Sclerodactyl, blood showing Anti-centromere antibody positive, the likely cause is - and explain in detail?
Ans. is 'a' i.e., CREST Patients scleroderma are typically classified based on the amount and location of skin involvement.SclerodermaDiffuse sclerodermaLimited sclerodermao Widespread skin involvementQo Rapid progression and early- visceral involvementQo Limited skin involvement, confined to fingers, forearms and faceo Slow progression, visceral involvement occurs late, some patients with limited disease also develop CREST syndrome which is a combination of C- Calcinosis distal : subcutaneous calcifications of fingers and along extensor surface of forearm R- Raynaud phenomenon E- Esophageal dysmotility S- Sclerodactyly (skin thickening limited to fingers) T- Telengiectasia (dilated capillaries)Age group in systemic sclerosiso Systemic sclerosis is primarily a disease of womenQ (F/M = 3:1).