You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Heme is conveed to bilirubin mainly in and explain in detail?
Heme is conveed to bilirubin by the macrophages of reticuloendothelial system. (Mainly in the spleen, but also in the liver and bone marrow). The tissue macrophage system includes the following phagocytic cells: * In bone marrow - lining of blood sinuses (littoral cells) * In liver - intervals along vascular capillaries (Kupffer cells) * In spleen - in the pulp * In lymph nodes - line the lymphatic paths The destruction of RBCs occur mostly in the capillaries of spleen as they have very thin lumen. Because of this, spleen is called the graveyard of RBCs.