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What is Which among the following is true about Super antigens? and explain in detail?
A group of antigens have been termed superantigens because they stimulate a much larger number of T cells than would be predicted based on the specificity of combining site diversity. This causes a massive cytokine release. The action of superantigens is based on their ability to bind directly to MHC proteins and to paicular V regions of the TCR without involving the antigen combining site. Individual superantigens recognize exposed poions defined by framework residues that are common to the structure of one or more V regions. Any T cells bearing those V sites may be directly stimulated. Ref: Ray C.G., Ryan K.J. (2010). Chapter 2. Immune Response to Infection. In C.G. Ray, K.J. Ryan (Eds), Sherris Medical Microbiology, 5e.