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What is Carbapenem with maximum seizure risk is and explain in detail?
* Imipenem is a Carbapenem group of Beta-Lactam antibiotic with highest propensity to induce seizures compared to the other Carbapenem congeners. * Seizure is noted in 1.5% patients receiving Imipenen. Seizure risk is increased in patients receiving high doses in the presence of renal insufficiency and CNS lesions. Ref:- Goodman & Gilman Pharmacological Basis of Therapeutics 13th Ed; Pg num:- 1035