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What is JAK-2 mutation is strongly associated with? and explain in detail?
Ans. is 'b' i.e., Polycythemia vera * Janus kinase 2 (JAK2), a member of the Janus kinase family, is a non-receptor tyrosine kinase.* JAK2 fusions with the TEL(ETV6) (TEL-JAK2) and PCM 1 have found to be associated with leukemia, particularly clonal eosinophilia forms of the disease.* JAK-2 mutations are associated withi) Polycythemia vera,ii) Essential thrombocythemiaiii) Myelofibrosis (and other myeloproliferative disorders)iv) Abnormal heart defects