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What is Which of the following drugs binds to albumin? and explain in detail?
Most drugs possess a physicochemical affinity for plasma proteins. Acidic drugs generally bind to plasma albumin and basic drugs to the a1 acid glycoprotein. Eg for acidic drugs: albumin ;Barbiturates,Benzodiazepines,NSAIDs,Valproic acid,Phenytoin,Penicillins,Sulfonamides,Tetracyclines,Tolbutamide,Warfarin To a1 acid glycoprotein basic drugs like b-blockers (Propranalolol), Bupivacaine,Lidocaine, Disopyramide ,Imipramine, Methadone, Prazosin, Quinidine, Verapamil binds Ref ;KD Tripathi Pharmacology 7th edition (page no; 19)