You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Two year old child presented with multiple bone defects and seborrheic dermatitis. Diagnosis ? and explain in detail?
Letterer Siwe disease - - child- <2yrs - generalised systemic involvement - Bone>skin>hepatosplenomgaly with lymphadenopathy -Skin- mc manifestation is seborrheic dermatitis. Current Classification Single-system Disease - either Localized (single site) or Multiple siteMultisystem Disease - Low-risk group (Disseminated disease with involvement of low-risk organs (skin, bone, lymphnode, pituitary) or High-risk group (Disseminated disease with involvement of one or more of the high-risk organs(hematopoietic system, lungs, liver, and spleen)