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What is MELAS inhibit all ETC Complexes EXCEPT: and explain in detail?
MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke) MELAS inhibits complex I, III & IV of ETC. It is an inherited condition due to NADH-Q oxidoreductase, Caused by a mutation in mitochondrial DNA Involved in Alzheimer disease and diabetes mellitus. ETC is affected, brain is affected and due to anaerobic metabolism, lactic acidosis occurs.