You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Treatment of choice for squamous anal carcinoma is and explain in detail?
Radiotherapy with concurrent chemotherapy (Chemoradiotherapy) is the standard of care for patients with nonmetastatic squamous cell anal cancer. Most patients treated with chemoradiotherapy have an excellent prognosis. Nigro Regime :Initial radiotherapy for 3 weeks 3000 rads (30 Gy total) to perineum and pelvis. Then chemotherapy--5 FU, for 4-5 days; is a radiosensitizer, staed on 1st day of as 1000 mg/m2 continuous infusion. Mitomycin C is 15 mg/m2 as single dose on 1st day of . Reference : page 987 SRB's manual of surgery 5th edition