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What is What does not occur in lysosomal storage disorders? and explain in detail?
Ref: TEXTBOOK OF PATHOLOGY 6th EDITION - HARSH MOHAN PAGE NO: 261 TABLE 10.2: Storage Diseases (Inborn Errors of Metabolism). Lysosomal storage disorders: * Inherited * Mutation in genes that code lysosomal hydrolases. * Lysosomal enzymes are used for the intracellular digestion/degradation of many complex biological macromolecules. * Deficiency of lysosomal enzymes: Inherited deficiency of lysosomal enzyme may cause incomplete catabolism of its normal macromolecular substrate. This can lead to the accumulation of the paially degraded insoluble substrate within the lysosomes. The inherited disorders result from mutations in genes that encode lysosomal hydrolases are known as lysosomal storage disorders.