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What is All of the following statements are true regarding sumatriptan except and explain in detail?
TRIPTANS Sumatriptan is the drug of choice for aboing acute attack of migraine. It acts as a selective agonist at 5 HT1B/1D receptors. This result in constriction of cranial vessels. It also suppresses the vomiting of migraine. It is a sho acting drug and has low oral bioavailability. Frovatriptan is the longest acting and rizatriptan is the fastest acting congener. All of these drugs can cause coronary vasospasm and are contraindicated in ischemic hea disease. Triptans are also contra-indicated in patients with hypeension, epilepsy, pregnancy, liver and renal impairment. Triptans and ergotamine should not be administered within 24 hours of each other.