You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Romana's sign is seen in: and explain in detail?
Romana's sign --the classic finding in Acute Chagas' disease (caused by the parasite Trypanosoma cruzi), which consists of unilateral painless edema of the palpebrae and periocular tissues--can result when the conjunctiva is the poal of entry. Initial local signs may be followed by malaise, fever, anorexia, and edema of the face and lower extremities. Generalized lymphadenopathy and hepatosplenomegaly may develop.