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What is When nitrates are combined with calcium channel blockers: and explain in detail?
Nitrates primarily decrease preload, while CCBs have a greater effect on afterload. Their concurrent use may decrease cardiac work to an extent not possible with either drug alone. This combination may be especially valuable in severe vasospastic angina. Eg for nitrates: GTN CCBs-amlo,felo,clevidipine, verapamil, diltiazem K D Tripathi: essentials of medical pharmacology; edition 6; pg no:533