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What is In acute inflammation due to the contraction of endothelial cell cytoskeleton, which of the following results and explain in detail?
Since the two major mechanisms of host defence against microbes i.e. antibodies and leucocytes are normally carried in the bloodstream, it is not surprising that vascular phenomenon plays a major role in acute inflammation 
Normally, plasma proteins and circulating cells are sequestered inside the vessels and move in the direction of flow.
In inflammation, blood vessels undergo a series of changes that are designed to maximize the movement of plasma proteins and circulating cells out of the circulation and into the site of injury or infection.

Changes in vessel
The changes occur in the following order
(i) Vasodilatation - the Earliest manifestation of acute inflammation sometimes it follows a transient constriction of arterioles.
ii. Vasodilation is quickly followed by increased permeability of the microvasculature.
iii. Stasis - Increased vascular permeability • The hallmark of acute inflammation is increased vascular permeability Acute inflammation has three major steps: -