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What is Clinically enzymes are classified as functional plasma enzymes and non functional plasma enzymes. Which among the following is an example for functional enzyme? and explain in detail?
Functional enzymes and non-functional enzymes: Functional plasma enzymes or specific enzymes have their substrates in the plasma itself. These enzymes are synthesized in the liver and actively secreted into plasma. Examples: Enzymes of blood coagulation, lipoprotein lipase, pseudocholinesterase. Nonfunctional enzymes or nonspecific enzymes are coming out from cells of various tissues due to normal wear and tear. Their normal levels in blood are very low; but are drastically increased during cell death or disease. Therefore assays of these enzymes are very useful in diagnosis of diseases. Examples: Alkaline phosphatase, acid phosphatase, lipase, amylase. Ref: Textbook of Biochemistry by DM Vasudevan, 5th edition, Page 53.