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What is Lucio phenomenon is treated with: and explain in detail?
Lucio phenomenon seen in leprosy- recurrent crops of large, sharply marginated, ulcerative lesions paicularly on the lower extremities. These are frequently fatal as a result of secondary infection and consequent septic bacteremia. Neither glucocoicoids nor thalidomide is effective against this syndrome. Optimal wound care and therapy for bacteremia are indicated. Ulcers tend to be chronic and heal poorly. In severe cases exchange transfusion is indicated. Extra edge : Lenalidomide (thalidomide derivative) is the drug of choice in MDS patients with 5q deletion, MDS with 5q deletion is lenalidomide responsive.