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What is Anti Spasmodic effect is seen with - and explain in detail?
Ans. is 'b' i.e., Propantheline Antispasmodic drugs i) Quaternary compounds - Propantheline, Oxyphenonium, Clidinium, Pipenzolate, Methylbromide, Isopropamide, Glycopyrrolate. ii) Teiary amines - Dicyclomine, Valethamate, Pirenzepine. iii) Vasoselective antispasmodic (drugs acting on urinary bladder) - Oxybutynin, Tolterodine, flavoxate. iv) Drotaverine Note? All above drugs are anticholinergic except drotaverine. Drotaverine is a non-anticholinergic smooth muscle antispasmodic which acts by inhibiting phosphodiesterase - 4 (PDE-4) selective for smooth muscle. Elevation of intracellular cAMP/cGMP causes smooth muscle relaxation. It is used in intestinal, biliary and renal causes, uterine spasm, irratable bowel syndrome.