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What is Drug NOT given in organophosphorous poisoning: September 2012 and explain in detail?
Ans. D i.e. Physostigmine Organophosphate poisoning It results from exposure to organophosphates (OPs), which cause the inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine (ACh) in the body. The effects of organophosphate poisoning on muscarinic receptors are recalled using the mnemonic SLUDGEM: (Salivation, Lacrimation, Urination, Defecation, Gastrointestinal motility, Emesis, miosis) An additional mnemonic is MUDDLES: miosis, urination, diarrhea, diaphoresis, lacrimation, excitation, and salivation. Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.