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What is Which of the following is a histological feature of Whipple's disease? and explain in detail?
Whipple's disease Hallmark - Presence of PAS +ve, diastase resistant granules inside foamy macrophages containing rod shaped bacilli. The presence of T. Whipplei outside macrophages is more impoant indicator of active disease than their presence inside the macrophages. Multisystem involvement: Joints (Early involvement) Intestine - Impaired lymphatic drainage resulting in malabsorption & diarrhea Lymph nodes CNS (Late involvement) Rx - Antibiotics