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What is Clinical diphtheria is caused by: (PGI June 2009) and explain in detail?
Ans: A (Corynebacterium . diph-theriae) "Diphtheria is a nasopharyngeal & skin infection caused by corynebacterium diphtheriaQ- H17th/890C. Ulcerans (H17th/893-95)# Cause exudative pharyngitis & cutaneous diseaseQ# Produce both diphtheria toxin & dermonecrotic toxinC. ulcerans infection is considered a zoonosis & person to person transmission has not been firmly establishedC. Pseudotuberctilosis (Preisz Nocard bacillusQ or C. Hofmannii)- H17th /894 & A 7th/240# Cause pseudotuberculosis''in sheep & suppurative lymphadenitis in horses#Not produce diphtheria toxin#It is part of normal flora of nasopharynxHuman infections- particularly endocarditis of either prosthetic valve or native valves & invasive pneumonia- have been identified only rarelyCorynebacterium Parvum (A7th/240)It is used as immunomodulatorStrptococcus Pyogens (A7th/204)Causes upper respiratory tract infection, pyoderma, rheumatic fever & glomerulonephritis