You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A new drug is found to be highly lipid soluble. It is metabolized at a slower rate of 10% per hour. On intravenous injection, it produces general anaesthesia that lasts only for 15 min. This short duration of anaesthesia is due to: and explain in detail?
- Highly lipid soluble drugs get initially distributed to organs with high blood flow (Brain, heart, kidney etc). Later to less vascular tissues (muscle, fat). The plasma concentration falls and the drug is withdrawn from these sites. If the site of action was in one of the highly perfused organs, redistribution results in termination of drug action. Greater the lipid solubility of the drug, faster is its redistribution. This is seen in Thiopentone.