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What is Drug not given with ketoconazole: and explain in detail?
(Ref: Goodman & Gillman s 13th ed. P 90)The common antifungal agent ketoconazole is a potent inhibitor of CYP3A4Therefore coadministration of ketoconazole with other CYP3A4 inhibitors like anti-HIV drug viral protease inhibitors (ritonavir, indinavir), clarithromycin, itraconazole, nefazodone, and grapefruit juice reduces the clearance of these drugs and increases its plasma concentration and the risk of toxicity. Hence these drugs are not given together.