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What is A 7 year old female child is brought to you with features of precocious pubey. On examination she has features of virilisation and is hypeensive. Which of the following enzyme deficiency is responsible for her condition? and explain in detail?
The features of 11 - hydroxylase deficiency in a female are precocious pubey, hypeension, virilization etc. Also know: 1) Hypeension occurs in 17 - hydroxylase and 11 - hydroxylase deficiency 2) Male pseudohermaphroditism occurs in 17 - hydroxylase and 3b-hydroxysteroid dehydrogenase deficiency 3) Female pseudohermaphroditism is seen in 21- hydroxylase and 11- hydroxylase deficiency. Ref: Ganong, Edition 20, Page - 353