You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Even in large dosages used in malaria, quinine does not cause toxicity, because : and explain in detail?
Ans. is 'b' elevated plasma alpha} acid glycoprotein. Patient with malaria can achieve high plasma level of quinine with few signs of toxicity because of the elevated plasma alpha 1 acid glycoproteins, produced during acute phase of infection. It prevents quinine toxicity through binding of most of the drug in the plasma.Peak plasma level which a person can achieve without producing toxicity.a. in severely ill patients -15-20 mg/litreb. in persons without malaria - 10 mg/litreAbout quinineIt is an erythrocytic schizonticide*Used for treatment of multidrug resistant strains of P. falciparumAssociated with a triad of dose related toxicitiesCinchonism*Hypotension*Hypoglycemia*