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What is Thiamine deficiency causes decreased energy production because and explain in detail?
thiamine deficiency causes a decrease in energy production because it acts as a coenzyme in many energy producing processes Thiamine generally function in the decarboxylation reaction of alpha-keto acids and branched chain amino acids Pyruvate Dehydrogenase which conves Pyruvate to Acetyl CoA aKetoGlutarate dehydrogenase in Citric Acid Cycle which conves a KetoGlutarate to Succinyl CoA Branched Chain Ketoacid dehydrogenase which catalyses the oxidative decarboxylation of Branched Chain Amino acids Trans Ketolase in the Pentose Phosphate Pathway. This is the biochemical basis of assay of Thiamine status of the body ref DM Vasudevan 8th ed page 467