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What is The poor prognostic factor associated with ALL in children is and explain in detail?
The standard features are age and WBC at diagnosis, with infants (less than one year), adolescents (greater than nine years), and children with WBC above 50,000/ml being at higher risk. Ceain chromosomal abnormalities are also strong predictors; in paicular, the Philadelphia chromosome and MLL gene rearrangements (especially in infants) are adverse features, while TEL-AML1 is orable. It is impoant to note, however, that even the most impoant known predictors explain only a small propoion of the variability in outcome. Testicular involvement Is a poor prognostic factor for ALL Reference: GHAI Essential pediatrics, 8th edition