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What is Locus heterogeneity is a feature of which of the following? and explain in detail?
TYPES OF HETEROGENEITY are
A. Allelic Heterogeneity,
B. Phenotypic Heterogeneity,
C. Locus or Nonallelic Heterogeneity.
Nonallelic or locus heterogeneity refers to the situation in which a similar disease phenotype results from mutations at different genetic loci. E.g Osteogenesis imperfecta, Albinism, Muscular dystrophy syndromes (dystrophin, most common cause of mus dystrophy and has large gene size).