You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is In which of the following organs are Kupffer's cells present? and explain in detail?
Kupffer cells are resident macrophages of the liver. They are located within the lumen of the sinusoids overlapping the thinned endothelial wall. Kupffer cells represents the largest population of macrophages in the mammalian body and are largely responsible for clearing the post mesenteric blood of gut derived bacteria and potent bacterial toxins such as endotoxins or peptidoglycans. Morphologically they are different from other macrophages as they show a characteristic pattern of endogenous peroxidase staining of the rough endoplasmic reticulum and perinuclear envelope. They express CD68 antigen and they also possess cell specific antigens eg: glucose/fructose receptor. Ref: Cooperation of Liver Cells in Health and Disease: With 18 Tables By Zbigniew Kmie? page 21.