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What is Gleason's classification used for and explain in detail?
(Carcinoma Prostate) (699- Basic robbins 8th)GLEASON - SYSTEM - Gleason grade has proved to correlate reasonably well with both the anatomic stage of prostatic carcinoma and the prognosis* Pancreatic cancer probably arise from precursor lesion (Pan INs) developing by a progressive accumulation of characteristic mutations of oncogenes (eg K-RAS) and tumor suppressor genes (eg P16, P53 and SMA D4)* Breast cancer - the majority are in the BRCA-1 and BRCA2 genes, less commonly in P53, PTEN or ATM genes