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What is Wegener's granulomatosis is diagnosed by: and explain in detail?
Ans. (b) c-ANCARef.:Harrison 18th edition, Chapter 326:* c- ANCA= Wegener granulomatosis/Granulomatosis with angitis* p-ANCA# Microscopic polyangitis# Primary sclerosing cholangitis# Churg strauss syndromeThe terminology of cytoplasmic ANCA (cANCA) refers to the diffuse, granular cytoplasmic staining pattern observed by immunofluorescence microscopy when serum antibodies bind to indicator neutrophils. Proteinase-3, a 29-kDa neutral serine proteinase present in neutrophil azurophilic granules, is the major cANCA antigen.