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What is Regarding POEMS syndrome, which of the following are true or false? a) Organomegaly is described as a feature but rare in POEMS syndrome b) Patients usually have a severe, progressive sensorimotor polyneuropathy c) Type 2 diabetes mellitus occurs in about one-third of patients d) Amenorrhea in women and impotence and gynecomastia in men is seen e) The lymphadenopathy although rare, resembles Castleman's disease histologically and explain in detail?
Polyneuropathy, Organomegaly, Endocrinopathy, Multiple myeloma, and Skin changes (POEMS). Patients usually have a severe, progressive sensorimotor polyneuropathy associated with sclerotic bone lesions from myeloma. Unlike typical myeloma, hepatomegaly and lymphadenopathy occur in about two-thirds of patients, and splenomegaly is seen in one-third. The lymphadenopathy frequently resembles Castleman's disease histologically, a condition that has been linked to IL-6 overproduction. The endocrine manifestations include amenorrhea in women and impotence and gynecomastia in men. Type 2 diabetes mellitus occurs in about one-third of patients. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 943