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What is One has to be careful about hypoglycaemia when patient gives history of taking this drug: and explain in detail?
Chlorpropamide: It is a long-acting sulfonylurea oral hypoglycaemic, found to reduce urine volume in DI of pituitary origin, but not in renal DI. It sensitizes the kidney to ADH action. 
DI = Diabetes Insipidus.
Due to its long duration of action, one has to be careful about hypoglycaemia, when patient gives history of taking this drug.
Reference: Essentials of Medical Pharmacology Eighth Edition KD  TRIPATHI  page no 644