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What is Within the RCBC, hypoxia stimulates glycolysis by which of the following regulating pathways? and explain in detail?
Rapapo Leubering Cycle (BPG Shunt) In the erythrocytes, step 6 of glycolysis is bypassed. Bis phosphoglycerate mutase conves 1,3- bisphosphoglycerate (BPG) to 2,3-BPG. Then BPG phosphatase removes the phosphate group to form 3-phosphoglycerate Significance of BPGThe 2,3-BPG combines with hemoglobin and reduces the affinity towards oxygen. So, in presence of 2,3-BPG, oxyhemoglobin will unload oxygen more easily in tissues.Under hypoxic conditions, the 2,3-BPG concentration in the RBC increases, thus oring the release of oxygen to the tissues even when PO2 is lowThe compensatory increase in 2,3-BPG in high altitudes ors oxygen dissociation. BPG is increased in fetal circulation.In this shunt pathway, no ATP is generatedRef: DM Vasudevan, 7th edition, page no: 100