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What is A patient was started on fluphenazine. After few weeks of treatment, he started developing tremors, rigidity, bradykinesia and excessive salivation. First line of management for this patient is and explain in detail?
* Fluphenazine - D2 blocker (Anti-psychotic)* This is a case of typical antipsychotic induced parkinsonism.* The only group of drugs effective against "Pharmacological parkinsonism" (Drug induced parkinsonism) are Anti-cholinergic agents* Trihexyphenidyl:# Has high Central: Peripheral anticholinergic actions than atropine# Acts by reducing unbalanced cholinergic activity in striatum of parkinsonism patients# Order of relief of symptoms: Tremors > Rigidity > Hypokinesia# Peripheral actions - responsible for treatment of sialorrhea# Started at low dose and gradually increased