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What is Most specific antiemetic for chemotherapy induced vomiting is: and explain in detail?
Ans. (A) Granisetron(Ref: Harrison 20th/e p501)Drugs for chemotherapy induced vomiting5 HT3 blockers like ondansetron, granisetron, dolasetron, palonosetron and ramosetron are DOC for this condition.Palonosetron is most potent 5 HT3 blocker. Dolasetron may prolong QT interval.Palonosetron has longest t1/2 whereas ondansetron has shortest t1/2.Efficacy of these drugs increases if used along with antihistaminics, D2 blockers or dexamethasone.