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What is Thrombin activity is inhibited by and explain in detail?
Heparin is present in the luminal surface of vascular endothelium it acts as an anticoagulation by the following mechanism: Prevent conversion of prothrombin to thrombin Inhibit the action of thrombin Facilitate the action of antithrombin III Ref: Medical Physiology Indu Khurana 2015 edition, Page No:159 It is also used as intravenous anticoagulant. Dose-0.5 to 1mg/kg of bodyweight. Action lasts for 1.5 to 4 hrs Injected heparin is destroyed by an enzyme in blood called heparinase