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What is A patient on alcohol dependence was given a drug & to avoid alcohol as drug interaction would lead to adverse drug reaction - and explain in detail?
Ans. is 'a' i.e., Disulfiram o The most commonly used aversive drug for alcohol abuse is disulfiram.o Normally alcohol is metabolized by oxidation in liver.o Disulfiram inhibits the enzyme aldehyde dehydrogenaseo When alcohol is ingested after taking disulfiram, the concentration of acetaldehyde in tissues and blood rises and a number of highly distressing symptoms (aldehyde syndrome) are produced - Flushing, burning sensation, throbbing headache, perspiration, uneasiness, tightness in chest, dizziness, vomiting, visual disturbances, mental confusion, postural fainting and circulatory collapse.o Inhibition of aldehyde dehydrogenase with disulfiram is irreversible, synthesis of fresh enzyme is required for return of activity.