You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following gene mutations is most commonly associated with systemic mastocytosis? and explain in detail?
Myeloproliferative neoplasms Disorder Mutation/Translocation Chronic myeloid leukemia BCR-ABL1 fusion/translocation Polycythemia vera JAK2 mutations Essential thrombocythemia/Primary myelofibrosis JAK2, CALR, MPL mutations Systemic mastocytosis KIT mutations Chronic eosinophilic leukemia FIP1L1-PDGFRA fusion genePDE4DIP-PDGFRB fusion gene Chronic neutrophilic leukemia CSF3R mutations Myeloid neoplasms with eosinophilia Various fusion genes involving FGFR1, PDGFRA, PDGFRB, or JAK2