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What is Tyrosinemics are more susceptible to develop: and explain in detail?
Ans:D.)Hepatic CarcinomaTyrosinemia type I, hepatocellular carcinoma occurs in children who survive beyond 2 yrs.TYROSINEMIA TYPE IThe disease is due to a deficiency in fumaryl- acetoacetate hydrolase.Accumulation of fumarylacetoacetate and its metabolites, paicularly succinyl- acetone, in the urine.Characteristic cabbage-like odor occurs.Liver failure and renal tubular acidosis result.Treatment includes dietary restriction of phenylalanine and tyrosine, and substrate restriction using nitisinone.