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What is Sensitivity of central chemorecepter in COPD - and explain in detail?
Ans. is 'a' i.e., Decreased to H+ o Primary stimulus for central chemoreceptors is an increase in hydrogen ion concentration (H) in CSF. o But, central chemoreceptors are depressed in hypoxia (COPD causes hypoxic hypoxia). "Central chemoreceptors are not stimulated by hypoxia; rather like any other cells, they are depressed by- hypoxia " ___ Priciples of medical physiology o Thus, COPD will cause depression of central chemoreceptors to other stimuli as it causes hypoxic hypoxia.