You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is An 80 year old male presents to OPD with c/o rapidly enlarging neck mass and Hoarseness of voice . He gives a history of untreated papillary carcinoma of thyroid . What would be the likely diagnosis? and explain in detail?
Anaplastic carcinoma - Seen in 7th-8th decade -C/F Sudden increase in the size of swelling Severe pain over the swelling Most common route of spread- Direct invasion Evidence of compression of Trachea - Dyspnea Esophagus - Dysphagia Recurrent laryngeal nerve - Hoarseness of voice Most common site of metastasis - Lungs - Investigations IOC for Diagnosis- FNAC - Treatment For resectable tumor - Total thyroidectomy For unresectable tumor - Tracheostomy (lifesaving procedure when tumor is obstructing trachea) - Poor prognosis.