You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Myd88 L265p mutation is seen in: and explain in detail?
B i.e. Waldenstrom's macroglobulinemiaRef: Robbins 9th edition, page 538Explanation:Waldenstrom MacroglobulinemiaIndolent neoplasm.Also known as lymphoplasmacytic lymphoma.Involves bone marrow (100%), liver, spleen, lymph nodes (15 - 20%).Rare sites of involvement lung and testis (PGIMER exam options).IgM secretion.MYD88 mutation - virtually in all cases.Associated with cold agglutinin AIHA and Hyperviscosity syndrome in 15%.