You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is related to 'NARP'? and explain in detail?
Neurogenic weakness, ataxia, and retinitis pigmentosa (NARP) is characterized by moderate diffuse cerebral and cerebellar atrophy and symmetric lesions of the basal ganglia. The substitution of one nucleotide in the mitochondrial DNA at position 8993 gives rise to a maternally inherited syndrome of sensory NARP. The mutation creates a defective ATPase-6 of complex V of the mitochondrial respiratory chain. When >95% of mtDNA molecules are mutant, a more severe clinical neuroradiologic and neuropathologic picture (Leigh syndrome) emerges. Ref: Skorecki K., Mandel H. (2012). Chapter e18. Mitochondrial DNA and Heritable Traits and Diseases. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.