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What is Which anti-asthma drug is avoided with erythromycin? and explain in detail?
Erythromycin decreases the plasma clearance of theophylline hence may manifest theophylline toxicity. Theophylline follows zero order kinetics. It is metabolised by microsomal enzymes. hence prone to drug interaction. ENZYME INHIBTORS -Agents which inhibit its metabolism are - Erythromycin Ciprofloxacin Cimetidine Oral contraceptive Allopurinol ENZYME INDUCERS - Like rifampicin increases its clearance hence higher dose is required for action. Smoking Phenytoin phenobarbitone