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What is Molecular studies on an abdominal lymph node containing lymphoma demonstrate t (2;8)(p12; q24) translocation. This is most compatible with which of the following diseases? and explain in detail?
Burkitt's lymphoma is actually associated with three translocations. The common variant t(8; 14)(q24;q32), involving the oncogene myc on chromosome 8, and the heavy immunoglobulin chain on chromosome 14. The other two variants are: t(8;22)(q24;q11), involving myc and the lambda light chain immunoglobulin site, and t(2;8)(p12;q24), involving the kappa light chain and myc. Mantle cell lymphoma, multiple myeloma and small (not cleaved) cell lymphoma are associated with the t(11;14)(q13;q32) translocation involving bcl -1 and the heavy chain site.