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What is Which of the following agents used in hypeension is a prodrug that is conveed to its active form in the brain? and explain in detail?
Methyldopa (L-a-methyl-3,4-dihydroxyphenylalanine) is an analog of L-dopa. Methyldopa enters the brain an aromatic amino acid transpoer and is conveed to a-methyldopamine and a-methylnorepinephrine. Antihypeensive action appears to be due to stimulation of central a adrenoceptors by a-methylnorepinephrine or a-methyldopamine.Katzung Pharmacology 12th edition Pg: 175