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What is Most common association in MEN 1 is - and explain in detail?
Ans. is 'a' i.e. Gastrinoma "Gastrinomas are the most common pancreatic islet tumors in MEN1 patients, accounting for over half of all pancreatic islet tumors in these patients." - Clinical Neuroendocrinology p. 342"The most common islet neoplasm in MEN 1 secret pancreatic polypeptide & is nonfunctional, while gastrinoma is a most frequent functional tumor." - Essentials of General Surgery"The most common functional islet cell tumor in MEN1 is gastrinoma " - Oncology: An Evidence-Based Approach MEN-1(Wermer syndrome)o It involves primarily three glands1) Parathyroid (parathyroid hyperplasia/adenoma): Most common manifestation.2) Pituitary: Prolactinoma is the most common type of pituitary tumor in MEN-I.3) Pancreas: There is islet cell hyperplasia/adenoma.o Less common findings are pheochromocytoma, foregut carcinoid, lipomas and dermal angiofibroma