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What is Diagnosis of vitamin B1 deficiency is made by and explain in detail?
Diagnosis of Vit B1 deficiency is made by Transketolase activity.Biochemical Parameters In thiamine deficiency, blood thiamine is reduced, but pyruvate, alpha-ketoglutarate and lactate are increased. Erythrocyte transketolase activity is reduced; this is the earliest manifestation seen even before clinical disturbances.Reference: Textbook of Biochemistry by D M Vasudevan, sixth edition pg no. 392