You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Paget's disease is associated with _____: and explain in detail?
Ans. C. Increase in bone turnoverPaget's disease is characterized by increased bone turnover with enlargement and thickening of the bone, but the internal architecture of new bone is abnormal and so the bone is unusually brittle.Paget's disease is also called osteitis deformans.It manifests in 4th and 5th decade Males.The pathologic process in Paget's disease is initiated by overactive osteoclastic bone resorption followed by a compensatory increase in osteoblastic new bone formation.The presence of inclusion bodies resembling paramyxovirus in the pagetic osteoclasts suggests that the viral infection may contribute to the clinical features of Paget's disease.This results in a structurally disorganized mosaic of woven and lamellar bone.The following radiological image of Paget's disease shows widened diploic space and there are ill-defined sclerotic and lucent areas throughout. The cortex is thickened and irregular.