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What is Patient was given chloroquine & doxycycline for 7 days. Patient&;s fever decreases in 4 days but , peripheral smear showed occasional gametocytes of plasmodium falciparum. This type of drug resistance is - and explain in detail?
Types of Drug Resistance In defining criteria for resistance to the aminoquinolineantimalarial drugs, the WHO has described three grades of resistance following treatment (Low grade) R1 : Recrudescence of infection between 7 and 28 days of completing treatment following initial resolution of symptoms and parasite clearance. (High grade) R2 : Reduction of parasitaemia by > 75% at 48 hours but failure to clear parasites<br />within 7 days. R3 : Parasitaemia does not fall by >75% within 48 hours. (www.slideshare.net)