You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Von Recklinghausen disease is associated with: and explain in detail?
Ans. (d) All the aboveRef: Kanski 7/e, p. 854; Yanoff 2/e, p. 1098NF-1 is the most common phakomatosis. It is Autosomal Dominant (AD).Ocular features# Orbital Optic nerve glioma Spheno-orbita encephalocoele# Eyelid - Ipsilateral plexiform neurofibroma# Glaucoma - unilateral and congenital# Iris lesions Lisch nodules (Hamartomas) Ectropion uveae# Prominent corneal nerves# Choroidal nevi# Posterior subcapsular cataractNF1 (Von Recklinghausen disease)Diagnostic Criteria - 2 or more should be present >=6 cafe-au-lait macules Freckling (Axillary or inguinal) - Pathognomonic>=2 neurofibromas (any) or 1 plexiform neurofibroma (it involves the eyelid, gives the characteristic S- shaped deformity) Optic glioma Osseous lesion (such as sphenoid dysplasia)>=2 Lisch Nodules First degree relative with NF1,Mnemonic: CAN GOLF