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What is A 55-year-old female patient presents with duodenal ulcer. The most sensitive test to detect Helicobacter pylori is and explain in detail?
Urea breath test is the most sensitive test for diagnosis of Helicobacter pylori infection. Urea breath test: The patient drinks a solution of urea labeled with a radioactive Carbon-14 and then blows into a tube. If H. pylori urease is present, the urea is hydrolyzed, and labeled carbon dioxide is detected in breath samples. Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition