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What is Intraepidermal bullae formation occur in which of the following condition? and explain in detail?
Pemphigus vulgaris is an intraepidermal bullous disorder where the split is suprabasal. Pemphigus is an autoimmune disorder characterised by the production of IgG autoantibodies against desmoglein which are involved in intercellular adhesion. These antibodies induce keratinocytes to release serine proteases which dissolve the intercellular substance. The site of split in 4 main variants of pemphigus are: Pemphigus vulgaris: split is suprabasal Pemphigus vegetans: split is suprabasal Pemphigus foliaceus: blister is either in the granular layer or just below the horny layer Pemphigus erythematosus: blister is either in the granular layer or just below stratum corneum Ref: Illustrated Synopsis Of Dermatology & Sexually Transmitted Diseases By Khanna page 64.