You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which anesthetic is contraindicated in renal failure- and explain in detail?
Ans. is 'd' i.e., Methoxyflurane Methoxyflurane o It was most potent inhalation agent (least MAC), but is not used (now Halothane is most potent), o It should not be used in a closed circuit (reacts with rubber tubing of the closed circuit). o It has slowest onset & recovery (however now ether has slowest onset & recovery as methoxyflurane is not used), o The boiling point is more than water (104degC). o Intrarenal metabolism of methoxyflurane and subsequent intrarenal production of fluoride ion is the significant cause of methoxyflurane renal toxicity, o It can cause high output renal failure and hepatotoxicity.