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What is TRUE about sepsis related acute kidney injury is: and explain in detail?
AKI complicates more than 50% of cases of severe sepsis. Decreases in GFR with sepsis can occur even in the absence of ove hypotension Tubular injury associated with AKI in sepsis as manifest by the presence of tubular debris and casts in the urine. The hemodynamic effects of sepsis--arising from generalized aerial vasodilation, mediated in pa by cytokines that upregulate the expression of inducible NO synthase in the vasculature can lead to a reduction in GFR. Ref: Harrison-E-18, P-2294.