You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following drugs, if given with terfena dine, can cause ventricular arrhythmias and explain in detail?
Fexofenadine:- It is the active metabolite of Terfenadine, the first nonsedating SGA that was withdrawn because of several deaths due to polymorphic ventricular tachycarida (Torsades de pointes) occurring with its higher doses or when it was coadministered with CYP3A4 inhibitors (erythromycin, clarithromycin, ketoconazole, itraconazole, etc.). mech of toxicity:- Toxicity is based on blockade of delayed rectifier K+ channels in the hea at higher concentrations. Astemizole is another SGA banned for the same reason. Ref:- kd tripathi;pg num:-166