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What is The pathogenesis of hypochromic anemia in lead poisoning is due to - and explain in detail?
Iron should be combined with protoporphyrin to synthesize Heme. To synthesize protoporphyrin and combine it with iron, enzymes like ALA synthase, ALA dehydratase & Ferrochelatase are required. Lead inhibits heme synthesis by inhibiting enzymes ALA dehydratase & Ferrochelatase resulting in microcytic hypochromic anemia.