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What is Which of the following is not a feature of MEN type and explain in detail?
Ans: d (Adrenocortical adenoma)Ref: Harrison, 17 ed pg. 2359MEN I (Wermer's syndrome) is characterized by pituitary, parathyroid & pancreatic affection. Pheochromocytoma is seen in all three even though less common in MEN I MEN' I (wermer's)MEN IIA (sipple)MEN II BPi tut aryAdenomaHyperplasia ParathyroidHyperplasiaAdenomaCarcinomaHyperplasia PancreasIslet cell hyperplasia,AdenomaCarcinoma Adrenal Pheochromocy- tomaPheochrom- ocytomaThyroid Ccell hyperplasiaC-cell hyperplasia MedullarycarcinomaMedullary carcinomaMucocutan- eous ganglioneu- romaMarta noidHabitus Less commonPheochromo- cytomaForgut carcinoidSubcutaneous/ visceral lipomaDermal angiofibroma Mutant gene RETRET MEN Hirschsprung - loss of function in RET protooncogene MEN 2A - gain of function in RET protooncogene.Please don't confuse Wermer's syndrome (MEN 1) with Werner's syndrome which is adult progeria. It is a rare condition and predisposes to papillary cancer thyroid.