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What is Not present in Sideroblastic anaemia is ? and explain in detail?
Ans. is 'b' i.e., Decreased transferrin saturation Sideroblastic anemia Sideroblastic anemia is a type of anemia in which the body has adequate amount of iron but is unable to corporate it into hemoglobin. Pathogensis o The basis defect is a failure to completely form heme molecules, whose biosynthesis takes place paly in the mitochondria. o The iron enters into the mitochondria, but cannot be utilized to synthesize heme. So iron, accumulates in mitochrondria giving a ringed appearance --> Ringed sideroblast. o Because these ringed sideroblastis can develop poorly or not at all into mature RBCs, anemia is a consequence.