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What is In alzhemires which is deficient in coex? and explain in detail?
AcH REF: Harrison's 17th ed chapter 365 Biochemically, AD is associated with a decrease in the cerebral coical levels of several proteins and neurotransmitters, especially acetylcholine, its synthetic enzyme choline acetyltransferase, and nicotinic cholinergic receptors. Reduction of acetylcholine may be related in pa to degeneration of cholinergic neurons in the nucleus basalis of Meyne that project to many areas of coex. There is also reduction in norepinephrine levels in brainstem nuclei such as the locus coeruleus.