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What is Which of the following play the most impoant role in pathogenesis of Rheumatoid Ahritis and explain in detail?
CD4+ T cells plays the most impoant role in orchestrating the chronic inflammatory response in Rheumatoid Ahritis. CD4+ T cells are the major component of the inflammatory infiltrate in the rheumatoid synovium. Chronic inflammatory response in Rheumatoid Ahritis T cells (CD4) are the major component of the inflammatory infiltrate in the rheumatoid synovium. The T cells compromise 30-50% of the infiltrate, with the other cells accounting for the remainder. Evidence suggests that CD4+ T cells play an impoant role in orchestrating the chronic inflammatory response in RA. However, other cell types, such as CD8+ T cells, natural killer (NK) cells, and B cells are present in synol tissue and may also influence pathogenic responses The inflammatory infiltrate is made up of no less than six cell types: T cells (Most abundant) B cells Plasma cells Dendritic cells Mast cells and Granulocytes (to a lesser extent) Ref: Harrison&;s 19th edition Pgno: 2140