You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is true about nephrogenic diabetes insipidus and explain in detail?
Answer is A (Renal tubule is unresponsive to ADH): Nephrogenic Diabetes Insipidus is charachterized by resistance of action of ADH on Renal tubules or unresponsiveness of renal tubules to the action of ADH or Renal Hyposensitivity to action of ADH. Serum sodium is typically high (increased), urine osmolality is low and fails to increase after exogenous administration of ADH /vasopression.