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What is Haemoglobin F is raised in: and explain in detail?
Answer is A (Juvenile CML) Fetal Haemoglobin levels (HbF) are increased in most cases of Juvenile CML - Causes of Raised HbF levels (Interpretation of Diagnostic Test 8th/411, 412) Haemoglobinopathies - b thalassemia major - b thalassemia minor - Sickle cell disease Hereditary Persistance of HbF Anemia: - Non Hereditary refractory normoblastic anemia - Pernicious anemia - Aplastic anemia Leukemia specially Juvenile Myeloid Leukemia Multiple myeloma Molar pregnancy Patients with Trisomy 13 or Trisomy 21 (Down's syndrome) Some chronic viral infections (eg CMV, EBV)