You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which region begins closure of the neural tube? and explain in detail?
After the notochord induces the formation of the neural plate, the lateral edges of the plate fold dorsally to form the neural groove. The lips of the neural groove grow toward the midline and fuse to form the neural tube. This closure of the neural tube occurs first in the cervical region and progresses cranially and caudally simultaneously. Failure of the neural tube to close results in a variety of congenital abnormalities that include anencephaly and spina bifida with myeloschisis.