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What is The tumor suppressor gene p53 induces cell cycle arrest at: and explain in detail?
G1/S check-point is controlled by p53 whereas G2/M check-point has both p53 dependent as well as independent mechanisms. p53 induces the synthesis of p21 which inhibits cyclin D/Cdk4. This results in stoppage of activation of Rb and cell cycle is arrested in G1/S phase. Fig:- Role of P53 in maintaining the integrity of the genome