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What is Blockade of nerve conduction by a local anesthetic is characterized by: and explain in detail?
Essentials of medical pharmacology, seventh edition , page no=361, Local anaesthetics block nerve conduction by decreasing the entry of sodium ions during upstroke of action potential. They interact with a receptor situated within the voltage sentive sodium channel and raise the threshold of channel opening. Hence optuon 2 is the answer since they have to cross the cell membrane to block the nerves.