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What is In a hemoglobin molecule which of the following is a homologous substitution for valine? and explain in detail?
Valine can be replaced by glutamic acid. At position number 67 in the amino acid sequence, three different amino acid substitutions have been found in different varient hemoglobins. Hb Sydney Valine - Alanine; Hb M Milwaukee Valine - Glu; & Hb Bristol Val - Asp. All of these are functionally normal hemoglobin types. Ref: Harper's Biochemistry, 26th Edition, Page 362 ; Color Atlas of Genetics By Eberhard Passarge, 2007, Page 348