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What is True statement about p53 are all except and explain in detail?
TP53 Transcription factor; Has propeies of both an oncogene and a tumour suppressor gene Small arm of Chr 17 (17p13.1) Protein product: p53 "Guardian of the genome"; "molecular policeman"; critical gatekeeper Li Fraumeni syndrome - Hereditary loss an allele Ca lung, colon, breast LOF mutation of TP53 - MC mutation in >50% cancers