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What is Liver cirrhosis is associated with which type of emphysema in Pizz phenotype mutation? and explain in detail?
In individuals with the Pizz phenotype, alpha 1 antitrypsin deficiency, its blood levels are less than 15% of normal, and patients are likely to develop panacinar emphysema at a young age; 50% of these patients will develop liver cirrhosis, because the A1AT is not secreted properly and instead accumulates in the liver. A liver biopsy in such cases will reveal PAS-positive, diastase-resistant granules.