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What is Thalidomide can be used in all of the following conditions, EXCEPT: and explain in detail?
Thalidomide has been used for many years in the treatment of some manifestations of leprosy and has been used for erythema nodosum leprosum; it is also useful in management of the skin manifestations of lupus erythematosus. The most impoant toxicity is teratogenesis. Because of this effect, thalidomide prescription and use are closely regulated by the manufacturer. Other adverse effects of thalidomide include peripheral neuropathy, constipation, rash, fatigue, hypothyroidism, and increased risk of deep vein thrombosis. In more serious cases of Behcet syndrome, thalidomide (100 mg/d) is effective. Ref: Lake D.F., Briggs A.D., Akporiaye E.T. (2012). Chapter 55. Immunopharmacology. In B.G. Katzung, S.B. Masters, A.J. Trevor (Eds), Basic & Clinical Pharmacology, 12e.