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What is Which of the following drugs have least affinity for CYP3A4? and explain in detail?
Ans. (D) Rabeprazole(Ref: Katzung 13th/1060, KDT 8th/e p701)Proton pump inhibitors are metabolized by CYP3A4 and CYP2C19. They are also inhibitors of these enzymes. Rabeprazole and pantoprazole has less affinity for these enzymes.