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What is Acetyl salicylate & phenobarbitone are better absorbed from stomach because they are- and explain in detail?
Ans. is 'a' i.e., Weak acids remain non-ionic at gastric pH Remember simple funda : When the medium is same drugs can cross the membrane: i) Acidic drugs can cross the membrane in acidic medium, i.e., acidic drugs are unionized at acidic pH and are lipid soluble --> so, in stomach acidic drugs are absorbed. ii) Basic drugs can cross the membrane in basic medium, i.e., basic drugs are unionized at alkaline pH and are lipid soluble --> so, in intestine basic drugs are absorbed.