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What is Emesis receptor is - and explain in detail?
Ans. is 'c' i.e., 5HT3 Vomiting centre and nucleus of tractus solitarius contain muscarinic, cholinergic and histamine H, receptors. CTZ is located in area postrema (outside BBB) and contains Dopamine D2, opioid & serotonine 5-HT3 receptors. o So, antiemetic that act on vomiting centre have antimuscarinic and antihistaminic action --> can allete vomiting from any cause. o Drugs acting on CTZ have Dopamine D, antagonistic and 5-HT3 antagonistic action --> effective only in vomiting mediated by stimulation of chemoreceptors (by morphine, cytotoxic drugs, digoxin).