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What is Bleomycin toxicity affects which type of cells: and explain in detail?
Ans. (A) Type I pneumocytes(Oncologic Emergencies by Sai Citing p92)Bleomycin causes necrosis of Type I pneumocytes that results in compensatory hyperplasia of type-II pneumocytes. Same kind of injury can also occur in response to radiations. In experimental models, this type of injury has been ameliorated by keratinocyte growth factor.