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What is The neo-adjuvant chemotherapy indicated in oesophageal carcinoma and explain in detail?
Treatment of CA esophagus High-grade dysplasia (Tis) or T1a Endoscopic mucosal resection Localised advanced cancer T1: Vagal sparing or transhiatal or minimal invasive esophagectomy with limited LN dissection T2 and T3: Neoadjuvant Chemoradiation + surgery Cervical SCC or Non-ideal candidate for resection : Definitive chemoradiation Locally advanced cancer Chemoradiation (+- surgical resection in T4a) Metastatic disease Definitive chemoradiation (for involved distant LN or metastatic disease) Malignant TEF Coated SEMS (Self expanding metallic stents) Chemotherapy regimen : Epirubicin + Cisplatin + 5-FU Ref: Shackelford 7th edition Pgno : 438-448