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What is Most common site of GIST is and explain in detail?
Gastrointestinal Stromal Tumors Gastrointestinal stromal tumors (GISTs) are the most common sarcomatous tumors of the GI tract. Originally thought to be a type of smooth muscle sarcoma, they are now known to be a distinct tumor derived from the interstitial cells of Cajal, an intestinal pacemaker cell. They can appear anywhere within the GI tract, although they are usually found in the stomach (40% to 60%), small intestine (30%), and colon (15%). GISTs vary con- siderably in their presentation and clinical course, ranging from small benign tumors to massive lesions with necrosis, hemorrhage, and wide metastases