You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A newborn baby presented with profuse bleeding from the umbilical stump after birth. Rest of the examination and PT, APTT are within normal limits. Most probable diagnosis is- and explain in detail?
Ans. (b) Glanzmann thrombasthenia(Ref: Robbins 9th/pg 660; 8th/pg 670)A newborn baby presented with profuse bleeding from the umbilical stump after birth.This is a case of severe inherited bleeding disorder. As PT & apTT are normal, Glanzmann thrombasthenia is the most probable cause, which can present with profuse bleeding soon after birth;It can be diagnosed by platelet aggregation studies, which will be defective.The other differential diagnosis in this scenario is Factor XIII deficiency (not given in the option)