You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is What is involved in formation of d-TMP from d-UMP: (PGI June 2007) and explain in detail?
Ans: A (N5, N10, Methylene tetrahydrofolate) Lippincott 4th/303-04: SaysdUMP is converted to dTMP by thymidylate synthase, which uses N5;N10'-methylene tetrahydrofoiate Q as the source of the methyl group. This is u nasal reaction in that tetrahydrofoiate {THF) contributes not only a one carbon unit but also fwo hydrogen atoms from the pteridine ring, resulting in the oxidation of THF to dihydrofolate (DHFJ.Inhibitors of thymidylate syn those includes thymine a nalogs such as 5-fluroruracil(DHF) can be reduced to THF by dihvdrofolate reductaseQ an enzyme that is inhibited in the presence of drugs such as methotrexateQ