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What is Which of the following is a suicidal enzyme and explain in detail?
Cyclooxygenase is a "Suicide Enzyme""Switching off " of prostaglandin activity is paly achieved by a remarkable propey of cyclooxygenase--that of self-catalyzed destruction; that is, it is a "suicide enzyme." Fuhermore, the inactivation of prostaglandins by 15-hydroxyprostaglandin dehydrogenase is rapid. Blocking the action of this enzyme with sulfasalazine or indomethacin can prolong the half-life of prostaglandins in the body.Ref: Harper&;s Biochemistry; 30th edition; Chapter 23; Biosynthesis of Fatty Acids & Eicosanoids