You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is What known chromosomal reason could explain for autosomal recessive disorders where one parent is unaffected and the other is a carrier to cause the condition for the child? and explain in detail?
An interesting corollary of uniparental disomy is that it can result in a child being affected by an autosomal recessive disorder when only one parent is a carrier for that disorder. The son or the daughter inherits two identical copies of the chromosome with the mutation (isodisomy) and so develops the disease. Uniparental disomy (UPD) occurs when a person receives two copies of a chromosome, or pa of a chromosome, from one parent and no copies from the other parent. Ref: Mosby's Medical Dictionary, 8th edition. (c) 2009, Elsevier; Nelson's Textbook of Paediatrics 17th Edition, Page 389; Metabolic Encephalopathies: Therapy and Prognosis By Stefano Di Donato, 1995, Page 198.