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What is Renal toxicity though negligible is associated with which of the following? and explain in detail?
Tenofovir is an acyclic nucleotide analogue and potent antiretroviral agent used to treat both wild-type and lamivudine-resistant HBV. Side effects: Negligible renal toxicity and mild reduction in bone density. Note: Telbivudine, a cytosine analogue Side effects: Asymptomatic creatine kinase elevation and peripheral neuropathy. Entecavir, a cyclopentyl guanosine analogue polymerase inhibitor (the most potent of the HBV antivirals) Lamivudine, inhibits reverse transcriptase activity of both HIV and HBV and is a potent and effective agent for patients with chronic hepatitis B. Ref: Harrison, Edition-18, Page-2573