You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is drug of choice for CMV retinitis? and explain in detail?
Doc for CMV retinitis - Ganciclovir Other drugs used - Foscarnet, cidofovir Herpes simplex virus (HSV), Varicella zoster virus (VZV) - Acyclovir Anti HIV drugs - Tenofovir, Abacavir Ganciclovir: Activated intracellularly by virus specific thymidine kinase Due to poor oral absorption, bioavailability of ganciclovir is low (<10%) It's prodrug valganciclovir ,which is better absorbed orally, has replaced it for oral therapy Systemic S/E: Bone marrow depression Rash ,fever,vomiting Neuro psychiatric disturbances