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What is Catecholamine hormones are synthesized in the: and explain in detail?
Ans. A. Chromaffin cells of adrenal medullaCatecholamines are synthesized by tyrosine. DOPA forms Dopamine in the cytosol which by Dopamine oxidase (Cu containing) forms Nor-epinephrine in the Chromaffin granules of pheochromocyte. This reaction requires copper and Vitamin C. Nor-epinephrine then enters cytoplasm and undergoes methylation by methionine to form Epinephrine. Both after synthesis enters in the chromaffin granules for storage.