You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Toxic shock syyndrome caused by staphylococcus is due to - and explain in detail?
The pyrogenic toxin superantigens are a family of small-molecular-size, structurally similar proteins that are responsible for two diseases: TSS and food poisoning. TSS results from the ability of enterotoxins and TSST-1 to function as T cell mitogens. Enterotoxins bind directly to the invariant region of MHC--outside the MHC class II groove. The enterotoxins can then bind T cell receptors the vb chain, and thisbinding results in a dramatic overexpansion of T cell clones (up to 20% of the total T cell population). The consequence of this T cell expansion is a "cytokine storm," with the release of inflammatory mediators that include interferon g, IL-1, IL-6, TNF-a, and TNF-b. The resulting multisystem disease produces a constellation of findings that mimic those in endotoxin shock; however, the pathogenic mechanisms differ. (Harrison's Principles of internal medicine, 20 th edition, page 1162)