You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Ram Prasad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and vd of tobramycin in him are 160ml/min and 40L ,respectively.if you wish to give Ram Prasad and intravenous loading dose to achieve the therapeutic plasma concentration of 4mg/L rapidly, how much should be given and explain in detail?
Ref-Katzung 10/e p45 Loading dise= Vd xtarget Plasma concentration =40Lx4mg/L =160mg clearance plays no role in the determination of loading dose. it is given to confuse you