You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is 'Train of four' is characteristically used in concern with and explain in detail?
Train-of-four stimulation devotes four successive 200 - ms stimuli in 2 s (2 Hz). The twitches in a train-of-four pattern progressively fade as relaxation increases. The ratio of the responses to the first and fouh twitches is a sensitive indicator of nondepolarizing muscle paralysis. Disappearance of the fouh twitch represents a 75% block, the third twitch an 80% block, and the second twitch a 90% block. Clinical relaxation usually requires 75-95% neuromuscular blockade. Ref: KD Tripathi 8th ed.