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What is Aldosterone synthesis is stimulated by which of the following? and explain in detail?
Mineralocoicoid secretion is stimulated by hyperkalemia, angiotensin-H, ACTH and hyponatremia, in reducing order of efficacy. 1. Aldosterone secretion in response to hyperkalemia is the most impoant and forms the basis for renal regulation of body potassium balance. 2. Stimulation of aldosterone by angiotensin II (through renin-angioensin system) is impoant for the correction of hypovolemia and hypotension in conditions like salt depletion or renal ischemia. 3. Stimulation of aldosterone secretion by ACTH results in diurnal variation of aldosterone secretion. 4. However, ACTH is not an impoant physiological regulator for aldosterone secretion. Hyponatremia is a weak stimulator of aldosterone secretion REF : HARRISONS 21ST ED