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What is Mechanism of action of digitalis in atrial fibrillation is: and explain in detail?
Digoxin reduces ventricular rate in A. Fib. by decreasing the number of impulses that are able to pass down the A-V node and bundle of His. It increases ERP of A-V node by direct, vagomimetic and antiadrenergic actions --> Minimum interval between consecutive impulses that can successfully traverse the conducting tissue is prolonged.