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What is The karyotype of a patient with Androgen Insensitivity Syndrome is: and explain in detail?
Androgen Insensitivity Syndrome is the largest single entity that leads to 46, XY undermasculinization. AIS is divided into three categories that are differentiated by the degree of genital masculinization: Complete Androgen Insensitivity Syndrome (CAIS) is indicated when the external genitalia is that of a normal female, Mild Androgen Insensitivity Syndrome (MAIS) is indicated when the external genitalia is that of a normal male, and Paial Androgen Insensitivity Syndrome (PAIS) is indicated when the external genitalia is paially, but not fully masculinized. Ref:Kligman, Behrman, Jenson, Stanton (2008), Chapter 589, "Disorders of Sex Development", In the book, "Nelson's Textbook of Pediatrics", Volume 2, 18th Edition, New Delhi, Page 1164