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What is Thiamine pyrophosphate is coenzyme required for all except rpt Q72 and explain in detail?
Thiamine pyrophosphate is the active form of thiamine. It serves as the coenzyme for the degradation or synthesis of alpha -ketols by trans ketolase (Figure 28.12A), and in the oxidative decarboxylation of a-keto acids (Figure 28.12B). A.Clinical indications for thiamine The oxidative decarboxylation of pyruvate and a-ketoglutarate, which plays a key role in energy metabolism of most cells, is paicularly impoant in tissues of the nervous system. In thiamine deficiency, the activity of these two dehydrogenase-catalyzed reactions is decreased, resulting in a decreased production of ATP and, thus, impaired cellular function. Ref: Lippincott, 5th edition, page no: 379