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What is Neurofibrillary tangles and agarophilic plaque are character-istic feature of and explain in detail?
Ans a: Ref: Harrison 17th ed pg 2541The area affected in Alzheimer's d/s are hippocampus temporal cortex and nucleus basalis of mayemet Microscopic finding are neurofibrillary tangles and senile neuritic plaques Neuritic plaque contain a central core that contain A? amyloid) proteoglycans, apoE4, alpha 1 antichymotrypsin &other proteinsAccumulation of A-beta amyloid on cerebral arterioles is amyloid angi-opathy.NFT- are silver staining, twisted neurofilaments in neuronal cytoplasm which represent abnormally phosphorylated tau protein