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What is Lambe Eaton syndrome is associated with and explain in detail?
Lambe-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that is characterized by muscle weakness of the limbs. Lambe-Eaton myasthenic syndrome is caused by autoantibodies to the presynaptic membrane. Myasthenia gravis is caused by autoantibodies to the postsynaptic acetylcholine receptors.Around 60% of those with LEMS have an underlying malignancy, most commonly small cell lung cancer Ref Harrison20th edition pg 2345