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What is Vitamin K is given to a patient with jaundice, but PT remains unchanged. Probable cause is and explain in detail?
An elevated prothrombin time indicates either vitamin K deficiency due to prolonged jaundice and malabsorption of vitamin K or significant hepatocellular dysfunction. The failure of the prothrombin time to correct with parenteral administration of vitamin K indicates severe hepatocellular injuryReference: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 58; Jaundice