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What is True fact regarding Crohn's disease is and explain in detail?
Crohn's diseaseHLA - DR1 / DQw5 and NOD genes, CD 4+ T cells response Affects ileum but rectum sparedFull-thickness - transmural involvement Skip lesions ++Non caseating granuloma ++Stricture ++Fistula ++Anal fissure ++Perianal abscess ++Discontinuous segmental asymmetrical colitis Normal vascular patternDiagnosis of Crohn's diseaseTreatment of Crohn's diseaseAssociated with Saccharomyces cerevisiae antibody Barium meal study - Cobblestone appearance; Rose thorn appearance; String sign of Kantor 5-ASAGlucocoicoidsAzathioprine and 6 Mercaptopurine (or Methotrexate)TNF alpha Therapy (Infliximab; Adalimumab; Ceolizumab)Cyclosporine or Tacrolimus or Natalizumab(Refer: Sabiston's Textbook of Surgery, 19th edition, pg no: 1244-1254)