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What is Aggrevation of symptoms of angina in a patient when given nitrates is seen in and explain in detail?
Ref Harrison 19 th ed pg 1568 Idiopathic hyperophic cardiomyopathy ( HOCM) is a dynamic outflow obstruction which is increased by any mechanism decreasing the preload . Nitrates decrease the preload,the volume of blood in LV and thereby increase the dynamic obstruction and symptom of angina