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What is SHBG is decreased in and explain in detail?
Sex hormone-binding globulin (SHBG),a plasma b-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in ceain types of liver disease and in hypehyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.Ref: Ganong&;s review of medical physiology;24th edition; page no:-427