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What is Skin pigmentation & Icthyosis like side effects are seen in and explain in detail?
Ichthyosis - Fish like scaling (d/t severe dryness in patient) - Causing skin to break Two types - Congenital Acquired I.vulgaris - Autosomal Dominant, MC type Deficiency - Filaggrin Involves Extensors Leprosy - Involvement of ANS No sweating - dry skin X linked ichthyosis - X-linked Recessive defect with steroid sulphatase Extensor + Flexors involvement Clofazimine - Causes darkening and dryness of skin Lamellar ichthyosis - Autosomal Recessive Defect with Transglutaminase Whole body involvement When infant born is covered with Membrane called collodion membrane then baby k/a collodion baby. Most severe type Ichthyosis - Harlequin ichthyosis - Autosomal Recessive- Due to ABCA-12 gene defect