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What is Marker of glomus tumor? and explain in detail?
Ans. is 'a' i.e., CD-57 Glomus tumor is a benign mesenchymal neoplasm of the subcutaneous tissue of the distal extremities and head & neck region. Immunohistochemistry shows smooth muscle actin, vimentin, collagen IV and CD-57, with little to no expression of neuroendocrine, endothelial or epithelial markers. Markers that have been proved consistently negative include cytokeratin, synaptophysin, chromogranin A, CD-31 and S-100 protein. Glomangioma (Glomuvenous malformation) Glomangioma is a variant of glomus tumor It is characterized by multiple tumors resembling cavernous hemangioma, lined by glomus cells. Glomangioma is blue-red, extremely painful vascular neoplasm. It involves a glomeriform aeriovenous anastomosis (glomus body) It may be found anywhere in the skin, most often in the distal poion offingers and toes, especially beneath the nails (subungal). Secondary thrombosis and phlebolith formation may occur in these lesions.