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What is Lymphohistiocytic variant of Reed Sternberg cells are typically seen in which of the following variants of Hodgkin&;s Lymphoma: and explain in detail?
Lymphocytic and histiocytic (L and H) variant of Hodgkin&;s Lymphoma is typical of Lymphocytic Predominant Hodgkin&;s Lymphoma. (True diagnostic Reed-Sternberg cells are not seen). The neoplastic cells resemble &;popcorn&; by viue of their folded or lobated nuclear nuclear membranes (nuclei resemble an exploded kernel of corn). Note that cells resembling the Lymphohistiocytic or popcorn cell variants of Lymphocyte Predominant (Non-classical) Hodgkin&;s Lymphoma may also be seen in Lymphocyte Rich Variant of Classical Hodgkin&;s Lymphoma. These if present can be differentiated by Immunophenotyping: Lymphocytic and Histiocytic (L & H) or &;popcorn&; cells are typical of Lymphocytic Predominant Non-Classical Hodgkin&;s Lymphoma. These cells are negative for CD15 and CD30 and positive for CD45. Cells resembling Lymphocytic and Histiocytic (L & H) or &;popcorn&; may be seen in Lymphocyte Rich form of classical Hodgkin&;s Lymphoma. These cells are positive for CD15 and CD30 and Negative for CD45. Ref: Bailey and Love 27th edition