You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A stem cell disorder affecting all the three cell lines platelets, RBCs and leucocytes is : and explain in detail?
Answer is C (Paroxysmal Nocturnal haemoglobinuria) Paroxysmal nocturnal haemoglobinuria (PNH) results from an acquired somatic mutation on the pleuripotent stem cells. Hence all its clonal progeny i.e. red cells, white cells and platelets are affected - Paroxysmal nocturnal haemoglobinuria: is an acquired clonal disease that is associated with abnormality of complement regulation. This defect affects the Pluripotent stem cells & the clonal progeny of these stem cells. Red cells, white cells & platelets thus all are affected. Paroxysmal cold haemoglobinuria, Black fan Diamond syndrome (pure red cell aplasia) and hemolytic anemias characteristically involve the red cell lineage only.