You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Esmolol is a short acting beta blocker because: and explain in detail?
(Ref Goodman & Gillman's 13th ed. P 216-17)Esmolol is a b1-selective antagonist with a rapid onset and a very short duration of action (t 1/2 = 8 minutes).The drug is hydrolyzed rapidly by esterase's in erythrocytes leading to its short half-life.Esmolol is used in urgent settings where immediate onset of b-blockade is warranted so it is given by slow intravenous injection.A partial loading dose (500mg/kg over 1 minute) typically is administered, followed by a continuous infusion of the drug (maintenance dose of 50mg/kg/minfor 4 minutes)The lipid solubility of esmolol is low and has no oral bioavailability so it is given via IV.The protein binding of esmolol is 55%.