You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 63-year old man presented with massive splenomegaly, lymphadenopathy and a total leucocyte count of 17000 per mm3. The flow cytometery showed CD 19 positive, CD 5 positive, CD 23 negative, monoclonal B-cells with bright kappa positively comprising 80% of the peripheral blood lymphoid cells. The most likely diagnosis is: and explain in detail?
Answer is A (Mantle cell lymphoma) The given clinical profile is suggestive of mantle cell lymphoma as explained below. (Mean Age = 63 yrs) Mantle cell lymphoma Presents in the middle aged and the elderly Clinical profile - Painless lymphadenopathy - Splenomegaly - Occasional GI involvement