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What is Earliest abnormality of diabetes nephropathy is- and explain in detail?
At the onset of diabetes, renal hyperophy and Glomerular hyperfiltration are present . Earliest abnormality is Glomerular hyperfiltration and earliest manifestation is abluminuria. In 40%of patients with diabetes who develop diabetic nephropathy ,the earliest manifestation is an increase in abluminuria detected by sensitive radioimmunoassay. Microalbuminuria appears 5-10 yrs after the onset of diabetes. Ref:Harrison 20 th edition pg no 2145