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What is Which of the following disease is associated with the presence of macrophages containing large quantities of undigested and paially digested bacteria in the intestinal mucosa? and explain in detail?
Small intestinal lamina propria laden with distended macrophages containing large quantities of undigested and paially digested bacteria is the hallmark feature of whipple's disease. The macrophages contain periodic acid schiff (PAS) positive granules and rod shaped bacilli. In whipple's disease, bacteria-laden macrophages can also be found in the mesenteric lymph nodes, synol membranes of affected joints, cardiac valves and the brain. Ref: Robbins Pathologic Basis of Disease, 6th Edition, Pages 814-5