You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Fifth clinical sign i.e., loss of function (functio laesa) was added by: and explain in detail?
Acute inflammation Four cardinal signs of inflammation was given by Celsus. Rubor (redness) Tumor (swelling) Calor (heat) Dolor (pain). These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function (functio laesa), was added by Rudolf Virchow in the 19th century. Metchinkoff described process of phagocytosis.