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What is Dusehene muscular dystrophy true - and explain in detail?
Ans. is 'c' i.e., Universal increase in creatine kinase Duchenne and Becker's muscular dystrophy are X-like recessive.o So expression of gene is essentially confirmed in males.o Females are affected only if X-chromosome carrying the normal allele is lost or inactivatedo Becker is milder form with late onset and slow progression,o In duchenni, onset is early with deloyed misection.o Pseudohypertrophy of calf muscle, glutei, deltiod,o Gower sign may positive at age of 3 year,o Cardiac involvement started at 10 year of age.o Histopathology shows diffuse degeneration & regeneration of muscle fibre,o Serum CPX are markedly high.