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What is True statement regarding mechanism of action of sulfonylureas is:- and explain in detail?
SULFONYLUREAS These bind to sulfonuyl urea receptors 1 (SUR1) on b cells of pancreas and inhibit ATP sensitive K+ channels. This cause depolarization of b cells resulting in release of insulin. These drugs are effective only if 30 % or more of the b cells in the pancreas are available. Major limitation of these drugs is like insulin, can also cause hypoglycemia.