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What is Which of the following statements are true regarding benzodiazepines? and explain in detail?
Benzodiazepines act on BZD receptors of GABAA-BZD receptor-chloride channel complex and increase the frequency of CI -channel opening GABA facilitatory action. Thus these are not GABA agonists. Coma, respiratory depression though rare,can occur with ultra sho acting agents like midazolam,thriazolam. Diazolam has rapid onset of action but prolonged action due to formation of active metabolized. Ref: KD Tripathi 8th ed.