You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which one of the following observations would rule out a sex- linked trait in an extended family pedigree? and explain in detail?
Sex-linked traits are passed via the X chromosome. Males transmit their Y chromosome to their sons and their X chromosomes to their daughters. Thus, an affected male cannot transmit a mutated X allele to his son, so the presence of male-to-male transmission in a pedigree categorically eliminates X-linked transmission as the genetic pattern of inheritance.