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What is SMAC/DIABLO is a and explain in detail?
Diablo homolog (DIABLO) is a mitochondrial proteinthat in humans is encoded by the DIABLO (direct IAPbinding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, ref Robbins 9/e p 19, and internet