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What is Which of the following drug is used in SIADH? and explain in detail?
Ans. A. TolvaptanTolvaptan:Vasopressin antagonists.Orally active nonpeptide selective V2 receptor antagonist.Metabolized by CYP3A4 - Not given to patients receiving this isoenzyme inhibitor.Given once daily.t 1/2 : 6-8 hours.Actions:Increases free water clearance by kidney (aquaretic).Corrects lower plasma Na+ levels.Uses:Useful for hyponatremia treatment.Hyponatremia caused by CHF, cirrhosis of liver or syndrome of inappropriate ADH secretion (SIADH).Side effect:Thirst & dry mouth (most frequent).Fever, G.I. upset & hyperglycaemia.