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What is All are true regarding diphtheria toxin EXCEPT : and explain in detail?
Ans. is 'd' i.e Toxin is necessary for local wound production " Corynebacterium Diptheria does not need to be toxigenic to establish localized infection, In the nasopharynx or skin, but non toxigenic strains do not yield the localized or systemic effect" - JawetzWhat I get from the above lines is that Non toxigenic strains of C diphtheriae can cause local wound production or infection but they will not be able to produce clinical effects.C.Diphtheriae produces a heat labile exotoxinThe production of this toxin depends largely on the concentration of Iron. Toxin production is optimal at 0.14mg/ml and is suppressed at 0.5 mg/mlThe toxigenicity of the Diptheria Bacillus depends on the presence in it of corynephages (tox+ i.e. toxigenic).Non toxigenic strains may be rendered toxigenic by infecting them with Beta phage or some other tox* phage.This is known as lysogenic conversion or phage conversion.Toxin inhibits the protein synthesis by inhibiting the polypeptide chain elongation.