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What is Prompt pump inhibitor suppress gastric acid secretion by acting on: and explain in detail?
PPIs(proton pump inhibitor): - Irreversible inhibitors- Example of HIT and RUN drugs- Exes systemic effect: normally acid labile, given with acid resistant coating.- DOC for: PUD, GERD, Zollinger Ellison syndrome- Prompt pump inhibitor suppress gastric acid secretion by acting on H+/K+ pump. Side effect: (chronic use): - Osteoporosis(decrease calcium)- Megaloblastic anemia(decrease vitamin B12)- Infection