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What is Zidovudine toxicity is increased by all except - and explain in detail?
Paracetamol increases zidovudine toxicity ,probably by competing for glucuronidation. Azole antifungals also inhibit AZT metabolism. Other nephrotoxic & myelosuppressive drugs & probenecid enhance toxicity . Reference :Tripathi textbook of pharmacology 7th edition pg no 807.