You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Mechanism of action of nifedipine is: and explain in detail?
Nifedipine It is the first and the prototype DHP, but infrequently used now. The overriding action is arteriolar dilatation → t.p.r. decreases, BP falls. The direct depressant action on heart is significant. As described above, it does not depress SA node or A-V conduction. Nifedipine acts rapidly, due to which reflex sympathetic stimulation of heart predominates producing tachycardia, increased contractility and CO. No decrease in venous return along with lowering of afterload aids increase in CO. Coronary flow is increased. The duration of action is short (3-6 hours).
Dose: 5-20 mg BD-TDS oral.
t.p.r = total peripheral resistance.
CO = Cardiac output.
Reference: Essentials of Medical Pharmacology Eighth Edition KD  TRIPATHI  page no 595