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What is All of the following are decreased in nephrotic syndrome, except ? and explain in detail?
Ans. is 'b' i.e., Serum Fibrinogen Fibrinogen level is increased in nephrotic syndrome d/t increased hepatic synthesis of fibrinogen. The largest propoion of protein lost in urine is albumin. Sometimes, globulins can also be excreted - - Immunoglobulin excretion increases the susceptibility of infection. Other proteins which are decreased - Transferrin - Microcytic hypochromic anemia. Cholecalciferol binding protein - hypocalcemia Thyroxine binding globulin - decreased thyroxine level. Antithrombin III - hypercoagulability Ceruloplasmin Causes of Hvpercoagulability in nephrotic syndrome Loss of antithrombin III Increased synthesis of fibrinogen by liver. Altered activity of protein C and S Increased platelet aggregability. Hypercoagulability can cause renal vein thrombosis.