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What is The presence of PAS-positive macrophages in the small intestine is a hallmark of and explain in detail?
Whipple's disease is a chronic multisystemic disease associated with diarrhoea, steatorrhea, weight loss, ahralgia, and central nervous system (CNS) and cardiac problems; it is caused by the bacterium Tropheryma whipplei. Until the identification of T. whipplei by polymerase chain reaction, the hallmark of Whipple's disease had been the presence of PAS-positive macrophages in the small intestine and other organs with evidence of diseaseThe treatment for Whipple's disease is double-strength trimethoprim-sulfamethoxazole for ~1 year. Harrison 19e pg: 1945