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What is Mast cell stabilizer used in Bronchial Asthma is and explain in detail?
Mast cells are impoant in initiating the acute bronchoconstrictor responses to allergens & several other indirectly acting stimuli like exercise and hyperventillation.Ketotifen is a mast cell stabilizer which reduces the stimulation of mast cells and mediator release is reduced(histamine,PGD2,leukotrienes). Dose:1-2 mg BD;children 0.5 mg BD Reference:Harrison' s medicine-18th edition,page no:2104;Textbook of pharmacology-K D Tripathi,7th edition,page no:229