You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A patient has been diagnosed with Marfan syndrome. Which of the following is the most common cause of death in these patients? and explain in detail?
Marfan syndrome Autosomal dominant Defect in an extracellular glycoprotein called fibrillin-1. Loss of fibrillin- Clinical manifestations of Marfan syndrome. Loss of structural suppo in microfibril rich connective tissue and excessive activation of TGF-b signaling. Skeletal abnormalities Unusually tall Exceptionally long extremities and long, Tapering fingers and toes. Cardiovascular lesions Mitral valve prolapse Aoic Dissection.