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What is Spironolactone is least commonly used in which of the following? and explain in detail?
Although spironolactone can be used for hypeension but it is not commonly used for this indication Spironolactone and epleronone antagonize the action of aldosterone These drugs act from the interstitial site of tubular cell (all other diuretics act from luminal side). These agents have maximum effect when aldosterone levels are high e.g. Hepatic cirrhosis CHF Nephrotic syndrome Primary hyperaldosteronism Spironolactone can be used for the treatment of hirsutism because of its anti-androgenic action. Canrenone is a metabolite of Spironolactone