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What is Topical administration of I% Pilocarpine failed to produce pupillary constriction in a patient who had a large, dilated pupil What should be the most probable reason? and explain in detail?
Ans. c. Pharmacological blockade (Ref-YANNOFF 3/E PG,1052-1055)Pilocarpine I% is a sufficient miotic dose for any eye, but a sphincter with all its cholinergic receptor blockade by atropine or tropicamide (i.e. eye with pharmacological blockade) does not constrict with pilocarpine 1%.