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What is A 58-year-old woman has a gastric ulcer, achlorhydria, and vibration sense loss in the lower extremities. She has a megaloblastic anemia. What test would help support a diagnosis of pernicious anemia? and explain in detail?
The Schilling test is performed by giving radiolabeled B12 orally (after saturating the B12 stores by intramuscular B12 ). In pernicious anemia, less than 3% of the label is found in the 24-hour urine collection (N>7%). Hemoglobin electrophoresis will detect defects in a- or b-globin chain synthesis, as seen in thalassemia (Mediterranean anemia).