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What is In unconjugated hyperbilirubinemia, which of the drug increase the chance for Kernicterus? and explain in detail?
Sulphonamides can precipitate kernicterus in the new born, especially if premature, by displacement of bilirubin from plasma protein binding sites and more permeable blood brain barrier. Hence it may lead to unconjugated hyperbilirubinemia. Free Bilirubin can become deposited in the basal ganglia and subthalamic nuclei of the brain, causing an encephalopathy called kernicterus. Ref:D. A. Warrell, Timothy M. Cox, John D. Fih (2005), Chapter 7 "Infection", In the book "Oxford Textbook of Medicine", 4th Edition, New york, Volume 1, Page 737