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What is Atropine/diphenoxylate and explain in detail?
Diphenoxylate/atropine, also known as co-phenotrope, is a combination of the medications diphenoxylate and atropine, used to treat diarrhea. It should not be used in those in whom Clostridioides difficile infection is a concern. It is taken by mouth. Onset is typically within an hour.Side effects may include abdominal pain, angioedema, glaucoma, heart problems, feeling tired, dry mouth, and trouble seeing. It is unclear if use in pregnancy is safe and use when breastfeeding may result in side effects in the baby. It works by decreasing contractions of the bowel.The combination was approved for medical use in the United States in 1960. It is available as a generic medication.  In 2019, it was the 339th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions. It is sold under the brand name Lomotil among others. The medication is in Schedule V in the United States.

Contraindications
Absolute contraindications are:
Patients under 6 years of age
Allergy to diphenoxylate or atropine
Diarrhea associated with pseudomembranous enterocolitis, diarrhea caused by antibiotic treatment, or diarrhea caused by enterotoxin-producing bacteria, such as Clostridium difficile
Obstructive jaundice

Side effects
The drug combination is generally safe in short-term use and with recommended dosage. In doses used for the treatment of diarrhea, whether acute or chronic, diphenoxylate has not produced addiction.
It may cause several side-effects, such as dry mouth, headache, constipation and blurred vision. Since it may also cause drowsiness or dizziness, it should not be used by motorists, operators of hazardous machinery, etc. It is not recommended for children under two years of age.

Interactions
Interactions with other drugs:

Antidepressants (e.g. Elavil, Prozac)
Monoamine oxidase inhibitors (e.g. Nardil, Parnate)
Opioid analgesics
Sedatives (e.g