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What is Megaloblastic anaemia due to folic acid deficiency is commonly due to - and explain in detail?
<p>Most dietary folate is present as polyglutamates;these are conveed to monoglutamate in the upper small intestine & actively transpoed into plasma.Plasma folate is loosely bound to plasma proteins such as proteins such as albumin & there is an enterohepatic circulation.Total body stores of folate are small & deficiency can occur in a matter of weeks</p><p>Serum folate is very insensitive to dietary intake; a single meal can normalise it in a patient with true folate deficiency.</p><p>Reference :Davidson&;s Principles & Practice of Medicine 22nd edition pg no1025</p>