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What is 1, 25 (OH)2 Cholecalciferol is formed in- and explain in detail?
25-hydroxy Cholecalciferol is formed in liver Whereas 1, 25 (OH)2 Cholecalciferol is formed in kidneys. Additional edge on synthesis of Vitamin D: Activation of 7-dehydro cholesterol by UV light in skin produces Cholecalciferol 25-hydroxylation in liver to form 25-hydroxy cholecalciferol 1-alpha- hydroxylation in kidneys to form 1,25 dihydroxy cholecalciferol PTH activates 1-alpha hydroxylase of kidneys