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What is A patient is having deficiency of Von Willebrand factor. Which of the following abnormalities are seen in this patient? and explain in detail?
Von Willebrand disease is caused by is deficiency of Von Willebrand factor (vWF), an adhesive protein that connects subendothelial collagen to activated platelets and also binds to circulating factor VIII. There will be prolonged bleeding time in the presence of normal platelet count, prothrombin time (PT) and paial thromboplastin time (PTT). Ref: Essentials of Pathophysiology: Concepts of Altered Health States by Carol Mattson Poh, 2010, Page 274 ; Handbook of Pediatric Hematology and Oncology: Children's Hospital and ... By Caroline A. Hastings, Joseph C. Torkildson, Anurag K. Agrawal, 2012, Page 66