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What is Genital elephantiasis is caused by - and explain in detail?
Ans. is 'd' i.e., Lymphogranuloma venerum Lymphogranuloma venerum (lymphogranuloma inguinale)o LGV is caused by chlamydia trachomatis , serotypes LI, L2, L3. Serotype L2 is the most common cause. The clinical course of LGV consist of following three stages: -1) First stage (Primary LGV) : - Self limited, Single, asymptomatic, painless, nonbleeding genital ulcer.2) Secondary stage : - Painful inguinal lymphadenopathy (Remember - Ulcer is pain less but lymphodenopathy is tender & painful). Swollen lymph nodes coalesce to form bubos , i.e., matted lymph nodes. Buboes may rupture to form discharging sinus. Groove's sign - Enlarge lymph nodes both above and below inguinal ligament.3) Tertiary LGV (genitorectal syndrome): - Characterized by proctocolitis.o Complications of LGV1) Esthiomene Enlargement, thickening and fibrosis of labia.2) Elephantiasis of the genitals3) Rectal stricture4) Systemic - Arthritis, pneumonitis, Perihepatitiso Frei's test was used for diagnosis (not used now)o Treatment - Doxycycline/tetracycline is DOC. Erythromycin is an alternative.