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What is Longest acting beta blokeris ? and explain in detail?
Ans. is 'a' i.e., Nodalol Nodalol is longest acting b-blocker. Esmolol is shoest acting b-blocker. Remember Nodalol is longest acting P-blocker. Esmolol is shoest acting n-blocker Acebutolol possesses all activities i.e., cardioselectivity, paial agonist activity, membrane stablizing activity and lipid insolubility. Beta blockers approved for treatment of CHF : Carvedilol (most widely used), metaprolol, bisoprolol. Carvedilol is a 13/ + 132 + al adrenoreceptor blocker with a : i3 blocking propey of I : 9. It produces peripheral vasodilatation due to a-1 blockade as well as calcium channel blockade (direct effect). Atenolol, sotalol and nodalol are primarily excreted by kidney - should not be given in renal failure. Sotalol, penbutolol and pindolol have almost 100% bioavailibility. Penbutolol has maximum oral absorption. Carvedilol has maximum plasma protein binding. Celiprolol has minimum plasma protein binding.