You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Eye examination of a child shows blue sclera. In which condition is it characteristically observed? and explain in detail?
Blue sclera is commonly seen in osteogenesis imperfecta. In this condition there is very thin sclera which allows the the blue color impaed by the underlying uveal tract to show through. It is not associated with any visual impairment. Other eye manifestations of this condition includes keratoconus, megalo-cornea, and corneal or lenticular opacities. Osteogenesis imperfecta is an autosomal dominant syndrome characterised by multiple fractures, blue sclera and deafness. The long bones are very fragile, fracture easily and heal with fibrous bony union. Ref: Vaughan & Asbury's General Ophthalmology, 18e, chapter 15