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What is Acid phosphastase cytochemical staining is used in the diagnosis of which of the following hematological neoplasms? and explain in detail?
Cytochemically demonstrable acid phosphatase has main diagnostic use is in the diagnosis of T-cell ALL and hairy cell leukaemia. In T cells, acid phosphatase is an early differentiation feature. Almost all acute and chronic T-lineage leukaemias show strong activity. In T-lineage ALL, the activity is usually highly localised (polar).