You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Lisch nodule seen in: and explain in detail?
(Neurofibromatosis) (2457-H 16th) (2607-H17th)* Neurofibromatosis (Von Recklinghausen's disease) - cutaneous neurofibroma* Cafe au lait spots* Freckling in non-sun exposed areas such as the axilla, hamartoma of the iris termed Lisch nodules.* Pseudoarthrosis of the tibia.Tuberous Sclerosis (Bournvilleis disease)Cutaneous Lesions* Adenoma sebaceus (Facial angiofibromas)* Ash-leaf shaped hypopigmented macula* Shagreen patch (Yellowish thickening of the skin over lumbosacral region of the back)* Depigmented nevi* Sub ependymal nodules* Subependymal giant cell astrocytoma* Rhabdomyomas of the myocardium and Angiomyomas of the kidney, liver, adrenal and pancreas.Von Hippel Lindav Syndrome - consist of retinal, cerebellar and spinal hemangioblastomas, Hypernephroma, renal cell carcinoma, pheochromocytoma, benign cysts of kidney, pancreas, epididymis or liver may occur.