You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A mother is diagnosed to have sickle cell disease, her husband is normal. What is the chances of having children with sickle cell disease and sickle cell trait respectively? and explain in detail?
Sickle cell anemia is an autosomal recessive disease. If mother has sickle cell disease (SS) and father is normal (AA), all of the offspring will be sickle cell trait (SA). Thus percentage of sickle cell disease (SS) will be zero and that of sickle cell trait (SA) will be 100%. Ref: Robbins Pathologic Basis of Disease, 7th Edition, Page 628 ; Children and Their Families: The Continuum of Care By Vicky R. Bowden, Page 1207