You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Regarding cholecystokinin-pancreozymin (CCK-PZ), all are true except (Repeat 2007 Q 42) and explain in detail?
Ans: a (Pepsinogen secretion is increased by gastrin and not by CCK-PZ)Pepsinogen secretion is increased by gastrin and not by CCK-PZ.Important points on GI hormones: CCK-PZSecretionGastrinFromJejunum (I cells)Uppersmall intestine (S cells)Antral portion of stomach (G cells)Stimulus- Protein digestion products- Protein digestion productsLuminal- protein products, distention- Fatty acids- Acids bathing mucosaNeural- vagal discharge (GRP)Blood- calcitonin, epinephrineAction1) Delays gastic emptying (Pyloric sphincter contra.)1) | HCO3- rich pancreatic juice1) Stimulate gastric acid & pepsin2) | duodenal emptying2) Augments action of CCK2) Trophic to stomach mucosa3) | motility of intestine & colon3) | gastric acid secretion3) Gastric motility4) | pancreatic secretion (enzyme rich)4) Pyloric sphincter contr.4) Stimulate insulin secretion5) Stimulate secretion6) GB contraction7) | glucagon secretion8) Trophic to pancreas