You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Pyruvate can be a substrate of all except and explain in detail?
BIOSYNTHESIS OF HEME - Heme can be synthesized by almost all the tissues in the body. Heme is synthesized in the normoblasts, but not in the matured erythrocytes. The pathway is paly cytoplasmic and paly mitochondrial. Step 1: ALA synthesis - The synthesis stas with the condensation of succinyl CoA and glycine in the presence of pyridoxal phosphate to form delta amino levulinic acid (ALA). Hence, anemia may be manifested in pyridoxal deficiency. The enzyme ALA synthase is located in the mitochondria and is the rate-limiting enzyme of the pathway. REF: DM VASUDEVAN TEXTBOOK OF BIOCHEMISTRY, SIXTH EDITION,PG.NO.,325.