You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is All the following are true about multiple myeloma except: and explain in detail?
Answer is B (t (8-14) translocation) A variety of chromosomal alterations have been found in patients with Multiple myeloma. The most common translocation is t (11; 14) (q 13; q32). 13q14 deletions and 17p13 deletions and 11 q abnormalities predominate. Translocation 1(8-14) has not been mentioned. Complete Immunoglobulin chain comprises of both heavy chains and light chains. But in Multiple myeloma there is excess production of light chains e over heavy chains. These light chains are eliminated in urine as Bence Jones proteinQ Protein cast in urine are thus made up of light chains only Q (not complete immunoglobulin chains). Bone lesions in multiple myeloma are lytic in nature and are rarely associated with osteoblastic new bone formation.' - Harrison. Bone lesions in MM are caused by the proliferation of tumor cells and activation of osteoclasts that destroy the bone. 'Bone pain is the most common symptom in MM affecting 70% of patients Q'-Harrison