You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 67-year-old woman with a prosthetic aoic valve develops progressive anemia. Examination of a peripheral blood smear reveals reticulocytosis and schistocytes. What is the appropriate diagnosis? and explain in detail?
- Given features suggests the diagnosis of Macroangiopathic hemolytic anemia Macroangiopathic hemolytic anemia most commonly results from direct erythrocyte trauma due to abnormal vascular surface (e.g., prosthetic hea valve, synthetic vascular graft). Anemia is mild to moderate & is accompanied by an appropriate reticulocyte response. Blood smear examination reveals fragmented red blood cells (schistocytes) and polychromasia. Although microangiopathic hemolytic anemia results in morphologically-similar red blood cells, it reflects changes in small blood vessels.