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What is Immunohistochemistry of a sample shows HMB 45. It is a marker for the following malignancy? and explain in detail?
Immunohistochemistry is a specialized form of histology employing antibodies to identify specific proteins within the tumor to allow for better differentiation of tumor type. Ceain immunohistochemical stains for neoplasms: Immunohistochemical Stain Neoplasms that Stain Positive Cytokeratin Carcinomas Desmin Benign and malignant neoplasms of smooth and skeletal muscle Glial fibrillary acidic protein (GFAP) Astrocytomas HMB-45 Melanoma Alpha fetoprotein (AFP) Hepatocellular carcinoma, yolk sac tumor Chromogranin A Small cell carcinoma Ref: Wyatt C., Kemp W.L., Moos P.J., Burns D.K., Brown T.G. (2008). Chapter 4. Neoplasia. In C. Wyatt, W.L. Kemp, P.J. Moos, D.K. Burns, T.G. Brown (Eds), Pathology: The Big Picture.