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What is True about Merkel cells and explain in detail?
Merkel cells They are slow-adapting mechanoreceptors found in fingeips, lips, oral cavity, and hair follicle. 1) Found in stratum basale; communicate with neurons 2) CK20+ in perinuclear dot pattern sensitive/ specific for Merkel cells; also (+) for neurofilaments, S100, synaptophysin, chromogranin A, vasoactive intestinal peptide, neuron-specific enolase, and calcitonin gene-related peptide. 3) are derived from Ectoderm. Ref:- Review of Dermatology by Alikhan; pg num:-6