You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Tophi in gout found in all regions except -a)  Joint capsuleb)  Skinc)  Muscled)  Articular cartilagee)  Synovial membrane and explain in detail?
Tophi are pathognomic of gout. They are formed by large aggregations of urate crystals. The urate crystals are surrounded by -


Macrophages
Lymphocytes
Large foreign body giant cells


They are seen in the-


Articular cartilages of joints
Periarticular ligaments
Tendons and soft tissues
Achilles tendon
Ear lobes


Less common sites of involvement are -

a) Kidney
b) Nasal cartilage
c)  Skin of the finger tips, palms or soles.