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What is Which of the following substrates can't contribute to net gluconeogenesis in mammalian liver? and explain in detail?
Palmitate can't contribute to net gluconeogenesis in mammalian liver Palmitate Fatty acid with 16 carbon atoms Not a substrate of gluconeogenesis. Even chain fatty acids yield Acetyl CoA upon oxidation. Odd chain fatty acid acts as a substrates of gluconeogenesis Propionyl CoA- the product of their oxidation can enter TCA cycle through formation of succinyl CoA Alanine, pyruvate and glutamate are glucogenic.