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What is A 22 years old male presented with history of fever, sore throat and enlarged neck lymph nodes. He was ordered a Paul-Bunnell test with a suspicion of Infectious mononucleosis. What is the immunological basis behind the use of this test? and explain in detail?
Answer- A. Heterophile antibody testEpstein-Bat virus (EBV) infection includes specific antibodies to EBV and various unrelated non-EBV heterophile antibodies. These heterophile antibodies reuct to antigens from animal RBCs. Sheep RBCs agglutinate in the presence of heterophile antibodies and are the basis for the Paul-Butrnell test.