You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The sigmoid nature of Hb-O2 dissociation curve is because of: and explain in detail?
Ans. is 'a' i.e. Binding of one O2 molecule increases the affinity for next Hb also .Lehninger writes : "Hemoglobin must bind oxygen efficiently in lungs and release oxygen in the tissues, myoglobin, or any protein that binds oxygen with a hyperbolic binding curve, would be ill-suited to this function. A protein that binds O2 with high affinity would bind it efficiency in the lungs but would not release much of it in the tissues. If the protein oxygen with a sufficiently low affinity to release it easily in the tissues, it would not pick up much of oxygen in lungs.Haemoglobin solves this problem by undergoing a transition from a low affinity state (the *T state) to a high affinity state (the (R state) as more oxygen molecules are bound. As a result, the Haemoglobin hos a hybrids-shaped, or sigmoid*, binding curve for oxygen*. "