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What is Which of the following is most impoant molecule for antioxidant pathway in lens? and explain in detail?
Glutathione is the most impoant molecule for antioxidant pathway in lens. Preventive antioxidant mechanisms of lens : Glutathione Superoxide dismutase Catalase Ascorbate (VIT-C) Alpha-tocopherol (VIT -E) Carotenoids ascorbate and alpha tocopherol Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Glutathione Maintains the Ascorbate and alpha-tocopherol in the lens in the reduced state The normal lens contains sulphydryl-containing reduced glutathione and ascorbic acid (vitamin C), both ofwhich decrease with age and in cataract. * Auto-oxidation and high concentration of reduced glutathione in the lens maintains the lens proteins in a reduced state and ensures the integrity of the cell membrane pump Ros= Reactive Oxygen Species Reference: - Comprehensive ophthalmology A K Khurana 6th edition page 181 Parsons' Diseases of the Eye 22nd Edition page -188