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What is Epidural anaesthesia is initiated in Primigravida at 38 weeks gestation, with a bolus of 15mg of Bupivacaine. Within few minutes, fetal heart rate monitoring shows variable decelerations. If scalp pH reveals fetal acidosis, compared with a normal pH, the anaesthetic absorbed by fetus will be present in and explain in detail?
Local anaesthetics, being basic drugs become more ionized at low fetal pH. Ionized molecules are thus trapped on fetal side of circulation.