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What is E-cadherin mutation is seen in metastasis of which type of breast carcinoma and explain in detail?
Answer- B. Lobular CaMutation in gene encoding for E-cadherin (CDH-I) is associated with gastric carcinoma and lobular breast carcinoma.Detachment of tumor cells is thefrst step tn metastasis. Normally cells are glued to each other by adhesion moleculesE-cadherin. Normal function of E-cadherin is dependent on catenins that helps in linkage of cytoskeleton to E-cadherin.Down regulation of expression of either E cadherins or catenins results looseining of cells that helps ln metastasis.