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What is In humans, rate limiting step of de novo pyrimidine synthesis is: and explain in detail?
De-novo pyramidine synthesis Rate limiting step in mammals CPS II in bacteria Aspaate transcarbamoylase CPS I CPS II Rate-limiting enzyme of urea cycle Rate limiting step of pyrimidine synthesis Found in mitochondria Found in cytosol Uses ammonia as nitrogen source Uses glutamine as nitrogen source Requires N-acetylglutamate as positive allosteric activator Doesnt require N-acetylglutamate Hypoxanthine-guanine phosphoribosyltransferase(HP) catalyzes salvage of the purine bases guanine and hypoxanthine into GMP and IMP.