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What is Which of the following drugs can cause galactorrhea and explain in detail?
Ref: KDT, 6th ed. pg. 643* Galactorrhea is caused by increased level of prolactin.* Normally, this prolactin is in inhibited state by Dopamine.* Prolactin is under predominant inhibitory control of hypothalamus through PRIH (Prolactin Release Inhibitory Hormone), which is Dopamine that acts on pituitary lactotrope D2 receptor.* Dopaminergic agonist like bromocriptine, DA and cabergoline decrease plasma prolactin levels and is used to treat hyperprolactinemia.* Dopaminergic antagonists like chlorpromazine, haloperidol, metoclopramide causes hyperprolactinemia by blocking D2 receptors.