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What is Which of the following causes haemolytic anemia - and explain in detail?
In heriditary spherocytosis , as the age of RBC increases they undergo loss of membrane fragments and acheive spherical shape (spherocyte) . spherocytes are rigid inflexible and less deformable hence they get trapped in spleen to premature destruction resulting in hemolytic anemia. Referance:Exam preparatory manual for UGs -Pathology By Ramdas Nayak Page no:264 Ref Robbins 9/e pg 412