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What is Spironolactone should not be given with ? and explain in detail?
Ans. is 'c' i.e., ACE inhibitors o Spironolactone is a potassium sparing diuretic, therefore, it can cause hyperkalemia decreasing the potassium diuresis. o ACE inhibitors can also cause hyperkalemia by inhibiting the production of angiotensin I, an inmmediate precursor of angiotensin II. Angiotensin causes excretion of Kt by increasing the secretion of aldosterone (Normally aldosterone enhances absoion of Na' in distal tubules in exhange of active secretion of Kt). o ACE inhibitors decrease potassium excretion by inhibiting the generation of Angiotensin. o Therefore, More pronoundced hyperkalemia can occur in patients receiving ACE inhibitors with sprironolactone.