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What is All of the following are minor criteria for multiple myelorna except aEUR' and explain in detail?
Plasmacytoma on tissue biopsy [Ref Tejinder singh hematology p. 210, 21 1[ DIAGNOSTIC CRITERIA OF MULTIPLE MYELOMA (SALMON AND DURIE) Major criteria 1) Plasmacytoma on tissue biopsy!' 2) Bone marrow plasmocytosis > 30% of plasma cells. 3) Monoclonal globulin spike IgG > 35W1 (>3.5 g/dl) IgA > 20g/L (>2.0 g/dl) - Light chain excretion on urine electrophoresis 1g124 hrs Minor criteria 1) Bone marrow plasmacytosisu, 10-30% plasma cells. 2) Monoclonal globulin spike, lesser magnitude than in 3 3) Lytic bone lesionsQ. 4) Reduced normal immuzioglobulins < 50% - IgG < 600 mg/di - IgA < 100 mg/dl - IgM < 50 ingdl Criteria for multiple myeloma 1)1 major & I minor criteria OR 2)3 minor criteria that must include 1 and 2 of minor criteria.