You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is nephrotoxic and explain in detail?
Intrarenal metabolism of methoxyflurane and subsequent intrarenal production of fluoride ion is the significant cause of methoxyflurane renal toxicityIt can cause high output renal failure It was the most potent inhalation agent (least MAC), but not used now (now Halothane is most potent).It should not be used in closed circuit (reacts with rubber tubing of the closed circuit).(Refer: stoelting's pharmacology and physiology in anaesthetic practice, 5th edition, pg no.139)