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What is In Henoch schonlen purpura Ig and complement involved: and explain in detail?
Ans. (b) IgA, C 3Ref: Harrison 19th ed. / 2190* Henoch Schonlein purpura is a small-vessel vasculitis in which complexes of immunoglobulin A (IgA) and C3 are deposited on arterioles, capillaries, and venules.* As with IgA nephropathy, serum levels of IgA are high in HSP .* IgA nephropathy has a predilection for young adults while HSP is more predominant among children. Further, IgA nephropathy typically only affects the kidneys while HSP is a systemic disease.* HSP involves the skin and connective tissues, scrotum, joints, gastrointestinal tract and kidneys.* Investigation: IgA levels high, platelet count normal and skin biopsy (IOC).* Treatment: steroids