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What is Digoxin is used for treatment of congestive hea failure. It acts by inhibiting:- and explain in detail?
Digoxin acts by inhibiting Na+K+ATPase of myocardial fibres by binding to its extracellular face- Accumulation of sodium in the cardiac cell- increased intracellular calcium. This Ca2+ is shifted to sarcoplasmic reticulum with the help of SERCA for storage. Thus, during systole, entry of calcium from membrane Ca2+ channels triggers release of high amount of Ca2+ from the sarcoplasmic reticulum and result in increased contractility.