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What is Highly selective proteinuria is seen in and explain in detail?
Loss of glomerular basement membrane (GBM) polyanion has been proposed as a cause of the selective proteinuria in minimal change nephrotic syndrome (MCNS).The exact role of charge selectivity in the pathogenesis of nephrotic proteinuria remains controversial Proteinuria that is more than 85% albumin is selective proteinuria. Nonselective proteinuria, being a glomerular leakage of all plasma proteins, would not involve changes in glomerular net charge but rather a generalized defect in permeability Ref Harrison20th edition pg 287