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What is A 3 year old girl is found to have recurrent fractures after tril trauma. On taking a detailed history, several other family members were found to be affected by similar complaints. So, a pedigree cha was drawn, which is shown below. Which of the following is the mode of inheritance of this disorder? and explain in detail?
3 Golden rules of Pedigree Analysis are: If all children of an affected female have the disease - Mitochondrial inheritance If at least 1 of the parent is affected by disease - Dominant Inheritance Father to Son transmission - Rules out X- linked disease In the given pedigree, As all affected individuals have one parent affected, it is 'Dominant' inheritance. As there is a father-to-son transmission, it cannot be X-linked inheritance. So, the given pedigree shows 'Autosomal dominant' inheritance.