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What is Which of the following is most common hemoglobinopathy? and explain in detail?
*Any disease in which a mutation causes structurally abnormal hemoglobin is called "Hemoglobinopathy"Sickle cell disease is a common hereditary hemoglobinopathy caused by a point mutation in b-globin that promotes the polymerization of deoxygenated hemoglobin, leading to red cell distoion, hemolytic anemia, microvascular obstruction, and ischemic tissue damage.*Thalassemia is not considered as a type of hemoglobinopathy as the mutation causes absent globins, not abnormal globins. (Ref: Robbins 9/e p635)