You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is In patient with Vulval ulcer. Which of the following will lead to malignancy? and explain in detail?
Ans. (d) HPVRef. William's Gyenecology Ch 31HPV (16, 18) most comman cause of vulvar carcinoma.* HPV infects the female - vulva, vagina, and cervix* Male- urethra, penis, and scrotum.* Both genders -Perianal, anal, and oropharyngeal area.Salient Features of Vulvar CancerMC site- labia majora and minoraMC symptom pruritus.MC type- SCC, epidermoid type (same for vaginal CA)MC implicated factor- HPV 16,18.Premalignant lesion of vulva * VIN (MC) vulvar intraepithelial lesion* /ts ds* Condyloma accuminata* Lichen sclerosis* Erythroplasia of querat* Bowen disease (type of VIN)MC mode of spread- lymphatic1st LN- superficial inguinal LN2nd LN- deep inguinal LN