You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Max Joseph space is related to - and explain in detail?
Ans. is 'c' i.e., Lichen planus Histological feature of lichen planusThe earliest finding is an increase in epidermal Langerhans' cells, associated with a superficial perivascular infiltrate of lymphocytes and histiocytes, impinging on the dermal-epidermal junction (DEJ).Mild spongiosis is followed by vacuolar alteration and clefting along the DEJ, with accumulation of necrotic keratinocytes (colloid bodies).Irregular acanthosis of the epidermis, irregular thickening of the granular layer, and compact hyperkeratosis.A focal increase in thickness of the granular layer and infiltrate corresponds to the presence of Wickham's striae. Degenerating basal epidermal cells are transformed into colloid bodies (15-20 im diameter)The rete ridges may appear flattened or effaced ('saw-tooth' appearance), and focal separation from the dermis may lead to max Joseph spaces.In ' active ' L P, a band-like infiltrate of lymphocytes and histiocytes, rarely admixed with plasma cells obliterates the DEJ.Epidermal melanocytes are absent or considerably decreased in number, while pigmentary incontinence with dermal melanophages is characteristic.