You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 50 year old male presented with blurring of vision. Urine examination showed proteinuria. Fundus examination showed dot and blot haemorrhages, microaneurysm and cotton wool spots. Histopathology pic of kidney given below. Your diagnosis? and explain in detail?
Ans. (a) Kimmelstiel Wilson nodules(Ref: Robbins 9th edp 1118)Diabetic Nephropathy:The renal lesions include mainly: Glomerular lesions:*Basement membrane thickening and increased mesangial matrix in patients*Diffuse glomerulosclerosis#Increase in mesangial matrix associated with PAS+ basement membrane thickening, eventually obliterates mesangial cells, found in most individuals with disease of more than 10 years duration*Nodular glomerulosclerosis#Intercapillary glomerulosclerosis or Kimmelstiel- Wilson diseas