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What is A patient presented with haematuria with acute renal failure. On doing renal biopsy, it showed cresentric glomerulonephritis. Immunofluoresence findings showed C3 & IgG deposition. Most likely diagnosis among the following is? and explain in detail?
Answer- D. Acute post-infectious glomerulonephritisPSGN appears 1 to 4 weeks after infection of pharynx or skin by specific nephritogenic strains (12, 4 and 1) of group A beta hemolytic streptococci.The lesions are caused by Type III hypersensitivity reaction with immune complex deposition and complement activation, causing decreased complement level.Clinical features-HematuriaOliguria, Non-selective proteinuriaPSGN causes acute renal failure.By immunofluorescence microscopy, there are irregular granular deposits of IgG. IgM and C3 in the mesangium and along the basement membrane (starry sky appearance).