You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Anti-topoisomerase I is marker of: and explain in detail?
Two ANAs strongly associated with systemic sclerosis are as follows:- One of these,directed against DNA topoisomerase I (anti-Scl 70), is highly specific. Patients who have this antibody are more likely to have pulmonary fibrosis and peripheral vascular disease. The other, an anti-centromere antibody, is found in 20% to 30% of patients, who tend to have the CREST syndrome.