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What is Parkinsonism treatment involves and explain in detail?
(B) Balance of Ach & dopamine in striatum # PARKINSONISM (Paralysis Agitans):> The normally high concentration of dopamine in the basal ganglia of the brain is reduced in Parkinsonism, and pharmaco- logical attempts to restore dopaminergic activity with levodopa and dopamine agonists have been successful in alleviating many of the clinical features of the disorder.> An alternative but complementary approach has been restore the normal balance of cholinergic and dopaminergic influences on the basal ganglia with antimuscarinic drugs.> Central anticholinergics act by reducing unbalanced cholinergic activity in striatum of parkinsonian patients.> These are the only drugs effective in drug induced parkinsonism.> Central anticholinergics can be used alone in mild cases and when levodopa is contraindicated. Can be used in combination with levodopa to decrease its dose.