You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Most common type of Hodgkin's lymphoma : and explain in detail?
Ans. (a) Nodular sclerosisRef. Robbins pathology 9th ed. /607-610types of Hodgkins lymphomaNodular sclerosisIs the most common subtype and is composed of large tumor nodules showing scattered lacunar classical RS cells set in a background of reactive lymphocytes, eosinophils and plasma cells with varying degrees of collagen fibrosis/sclerosisMixed cellularityMost common format seen in India; also the commonest in HIV positive patients. Biopsy shows classic. Reed Sternberg cells Lymphocyte depletedIs a rare subtype, composed of large numbers of often pleomorphic RS cells with only a few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphomaLymphocyte-richGood/best prognosisNodular lymphocytic predominantExpresses CD20 and is classified as considered a form of non- classical Hodgkin's.*Microscopic examination of the lymph node biopsy reveals complete or partial effacement of the lymph node architecture by scattered large malignant cells known as Reed-Sternberg cells (RSC) admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells.*The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45-, CD30+, CD 15+/- immunophenotype. In approximately 50% of cases, the Reed-Sternberg cells are infected by the Epstein-Barr virus.*Characteristics of classic Reed-Sternberg cells include large size (20-50 micrometers), abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror- image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane (chromatin is distributed close to the nuclear membrane).