You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is First step in synthesis of eicosanoids is? and explain in detail?
Eicosanoids synthesis is governed by the rate of release of arachidonic acid from membrane lipids in response to appropriate stimuli. These stimuli activate hydrolases, including phospholipase A , which conves arachidonic acid into Prostaglandins, thromboxanes by the COX pathway or Leukotrienes and lipoxins by the LOX pathway Reference: Harpers illustrated biochemistry 31st edition Page no 224