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What is "Intranuclear inclusions" in oligodendrocytes are seen in and explain in detail?
progressive multifocal leukoencephalopathy, JC virus-infected oligodendroglia display 2 distinct patterns of intranuclear viral inclusions: full inclusions in which progeny virions are present throughout enlarged nuclei and dot-shaped inclusions in which virions are clustered in subnuclear domains termed "promyelocytic leukemia nuclear bodies" (PML-NBs) Surrounding the demyelinated areas, the oligodendrocytes are enlarged and contain intranuclear inclusionbodies filled with papovavirus paicles, often forming pseudocrystalline arrays Ref ganong's review of medical physiology 25e