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What is The following Thiazide diuretic is active even if GFR is less than 30-40 mm Hg? and explain in detail?
Although most thiazide diuretics lose their effectiveness in renal failure, metolazone remains active even when the glomerular filtration rate (GFR) is below 30-40 mL/min (moderate renal failure). This gives it a considerable advantage over other thiazide diuretics since renal and hea failure often coexist and contribute to fluid retention(Refer: K. D. Tripathi&;s Essentials of Medical Pharmacology, 7th edition, pg no: 583)