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What is HMGCoA reductase is inhibited by : and explain in detail?
Ans is 'a' Lovastatin (Ref. KDT, 5/e p. 577 (4/e, p. 620, 621); Harrison, 16/e, p 2296 (15/e, p. 2254)).Lovastatin is a hypolipidemic drug.Its mechanism of action is Inhibition of HMGCoA reductaseHMGCoA reductase inhibitors includeLovastatinMevastatinSimvastatinMechanism of action of other hypolipidemic drug.Fibric acid derivatives (Gemfibrozil)* - Activation of lipoprotein lipase*.Bile acid resins (Cholestyramine and colestipol)* - Interruption of enterohepatic recycling of bile acids*.Nicotinic acid - Unclear or (inhibition of lipolysis)*