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What is Which is found in DiGeorge&;s syndrome - and explain in detail?
Digeorge syndrome Digeorge syndrome is an example of a T cell deficiency that results from failure of development of the third and fouh pharyngeal pouches. * Clinical features * Enhanced susceptibility to viral, fungal (mucocutaneous candidiasis) and bacterial infections. * Facial abnormalities : Hypeelorism, abnormal ears, sho philtrum and micrognathia. Hypocalcemic tetany due to failure of parathyroid development. Congenital hea diseases eg fallot&;s tetralogy. * Absence of a normal thymus. * Serum immunoglobulin concentration are frequently normal, but antibody responses, paicularly of IgG and IgA isotypes, are usually impaired. * T cell levels are reduced (not total absence). * B cell levels are normal. REF: Harrison book of internal medicine 21ST EDITION