You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Two most important clinical features of primary biliary cirrhosisa) Generalized pruritusb) Jaundicec) Fatigued) Clubbinge) Hematemesis and explain in detail?
• MC indication for LT: Cirrhosis from Hepatitis C (HCV)
• 2nd MC indication for LT: Alcoholic liver disease
• MC indication for LT in children: Biliary atresia
• MC metabolic disorder requiring LT: Alpha-1 antitrypsin deficiency
• MC indication for LT following acute liver failure: Acetaminophen toxicity
• Sepsis and sepsis-induced multiple organ failure are the MC causes of death in liver transplantation.