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What is Which of the following anti TNF-a agents binds to both soluble and transmembrane bound forms of TNF-a? and explain in detail?
Anti-TNF-ALPHA blockers Initially developed for therapy of rheumatoid ahritis are in advanced trials for psoriasis. 2 main agents are Infliximab-Chimeric human-murine IgG antibody to TNF-ALPHA; Etanercept- Dimeric fusion protein consisting of the extracellular poion of the human p75 TNF-ALPHA receptor linked to the Fc poion of human IgG1.