You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Treatment with anti-hypeensive drug spironolactone leads to formation of spironolactone bodies in: and explain in detail?
Aldosterone-producing adenomas Solitary, small (<2 cm in diameter), well-circumscribed lesions Bright yellow on cut section and, surprisingly, are composed of lipid-laden coical cells that more closely resemble fasciculata cells than glomerulosa cells (the normal source of aldosterone). Hallmark feature is presence of eosinophilic, laminated cytoplasmic inclusions, known as spironolactone bodies, found after treatment with the antihypeensive drug spironolactone. Do not suppress ACTH secretion. Adjacent adrenal coex and that of the contralateral gland are not atrophic.