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What is What constitutes the driving force for transpo of proteins into and out of the nucleus? and explain in detail?
No ATP is involved at any point in nuclear transpo. The driving force for the transpo comes indirectly from a gradient created by GTP hydrolysis. The key controlling factor is the allosteric GTPase, Ran. Ran is only able to hydrolyze GTP to GDP in the cytosol because this process must be activated by a GTPase-activating protein (GAP) that is only present in the cytosol. Reference: Harper; 30th edition