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What is The clinical effects of Organophosphorous toxicity is due to inhibition of which enzyme and explain in detail?
The clinical effect of Oraganophosphorous poisoning is due to the inhibition of RBC cholinesterase Inhibition of cholinerasterase leads the accumulation of acetyl choline at the nerve synapses and neuromuscular junctions ,resulting in overstimulation of acetyl choline receptors.Excess acetyl choline accumulation results in cholinergic ***Acetylcholinestarase is found primarily in the erythrocytic membranes,Nervous tissue, skeletal muscle ***Butyrylcholinesterase found in serum, liver, pancreas, hea, brain ***Neuropathy target is an enzyme found in the Brain and kidney.It is hypothesized inhibition if this enzyme may be responsible delayed neuropathy (OPIDN) Reference:Textbook of Forensic Medicine and toxicology PG number 533