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What is Which fibrinolytic agent selectively activate fibrin bound plasminogen rather than circulating plasminogen and explain in detail?
FIBRINOLYTICS (Thrombolytics) Alteplase It is moderately specific for fibrin bound plasminogen, so that circulating fibrinogen is lowered only by ~ 50%. It is rapidly cleared by liver and inactivated by plasminogen activator inhibitor-1 (PAI-1). The plasma t 1/2 is 4-8 min. Because of the sho t 1/2 , it needs to be given by slow i.v. infusion and often requires heparin co-administration. It is nonantigenic, but nausea, mild hypotension and fever. Ref:- kd tripathi; pg num:-627