You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following drug has been withdrawn from the market? and explain in detail?
COXIBS which are selective cox 2 inhibitors are very rarely used and banned from the market due to the high incidence of Myocardial infarction and stroke. these disrupt the ration of TXA2 and PCI thromboxane and prostacycline which leads to long term risk of stroke. Ref: KD Tripathi 6th ed, pg 534 and 197