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What is Calcium blocking agents of use in the treatment of hypeension include and explain in detail?
Nifedipine The overriding action of Nifedipine is aeriolar dilation, t.p.r. decreases and BP falls.Doesn&;t depress SA node or A-V conduction.Reflex sympathetic stimulation of hea predominates leading to tachycardia, increased contractility and C.O., coronary flow is increased.Its use is associated with higher moality among post-MI patients.Relaxant effect on the bladder, Nifedipine can increase urine voiding difficulty in elderly malesContraindicationsSide effectsHea failure 2nd or 3rd-degree hea blockTachycardia, flushingGI disturbancesHyperkalemia, edema, headache(Refer: Harrison's Principles of Internal Medicine, 18th edition, pg no: 2054-2057)