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What is Inhibition of 5-lipooxygenase is useful in: and explain in detail?
Ans. (B) Bronchial asthma(Ref: KDT 8th/e p248, 249)Leukotrienes are potent bronchoconstricting agents. These agents play a major role in the pathogenesis of bronchial asthma. The drugs acting by inhibiting their synthesis (i.e. lipoxygenase inhibitors) or action (Cys-LT receptor antagonists), are useful in the prophylaxis of bronchial asthma.