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What is Warfarin skin necrosis is caused by- and explain in detail?
Ans. (a) Protein C/Protein S deficiency(Ref: Wintrobe's 12th/pg 1490)Warfarin skin necrosisDue to warfarin-induced rapid reduction in protein C levels in patients with a pre-existing inherited protein C deficiency that results in a hypercoagulable state and thrombosis.Not all heterozygous protein C-deficient patients receiving warfarin experience this complication, and not all patients with this complication have protein C deficiency.