You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is known as suicidal enzyme? (AIIMS November 2013, May 2013) and explain in detail?
Ans. b. Cyclooxygenase (Ref: Harper 27/e p204 Harrison 18/e p146Cyclooxygenase is a suicidal enzyme.Suicidal enzyme is one. which undergoes self-destruction in order to terminate its own acitivity. e.g. Cyclooxygenase.Switching off of prostaglandin activity is partly achieved by a remarkable property of cyclooxygenaseQ, that of self-catalyzed destruction, i.e. it is a 'suicidal enzyme'.Suicidal inhibition is conversion of a substrate by the enzyme into a metabolite, which is a potent inhibitor of the enzyme; example: Xanthine oxidase converts allopurinol to alloxanthine (oxypurinol), which is a more potent inhibitor of allopurinol.