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What is Which among the following class of antibiotics are relatively safer to use in patients on Warfarin therapy- and explain in detail?
Newer Cephalosporins (Cefamandole, Moxalactum, and Cefoperazone) cause hypoprothrombinemia. Thus, when anticoagulants are given with cephalosporins they have an additive anticoagulant action. * Imidazoles like ketoconazole and fluconazole affect hepatic drug metabolism and lead to raised plasma level of warfarin. * Macrolides inhibit hepatic oxidation of many drugs leading to raised plasma level of warfarin.