You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Recent drug for metastatic hormone receptor(+)and HER-2 (-) metastatic breast cancer : and explain in detail?
Palbociclib is a recent drug for metastatic hormone receptor(+)and HER-2 (-) breast cancer. It works by inhibiting Cyclin-dependent kinase 4/6. Other examples of this class of drug includes: Ribociclib, Abemaciclib. These drugs are used along with letrozole (aromatase inhibitor) and/or fulvestrant (selective estrogen-receptor downregulator) Herceptin/Trastuzumabis used in Her-2 neu positive breast cancer. Ipataseib is an AKT (Protein kinase B) inhibitor used in metastatic triple-negative breast cancer. Buparlisib is a Phophatidyl-inositol 3 kinase (PI3k) inhibitor which is still in trial stages for treatment of metastatic breast carcinoma