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What is Which of the following drug is an antihormonal substance used to induce ovulation? and explain in detail?
Clomiphene citrate is a nonsteroidal estrogen antagonist that increases FSH and LH levels by blocking estrogen negative feedback at the hypothalamus. Clomiphene citrate is approved by the FDA, as an ovulation-inducing drug. It is given orally in dosages of 50 to 100 mg/d for 5 days on a monthly basis to induce ovulation in infeile women. Ref: Textbook of gynecology by D C Dutta 4th Edition, Page 486-7.