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What is all the following are treatments used for PROMYLOCYTIC LEUKEMIA (m-3) EXCEPT? and explain in detail?
Acute Promyelocytic Leukemia * Without treatment, APL is the most malignant form of AML with a median survival of less than one month. * Modern therapy has dramatically changed its prognosis and APL is now associated with the highest propoion of AML patients who are cured of their disease. * APL represents a medical emergency with a high rate of early moality, due mainly to hemorrhagic complications from a characteristic coagulopathy. * The first golden rule that has to be followed as soon as the diagnosis of APL is suspected based upon cytologic criteria is: to immediately sta treatment with all-trans retinoic acid (ATRA) without delay, even before definitive (cyto)genetic confirmation of the diagnosis has been made. * If the diagnosis is not confirmed, ATRA can always be discontinued and treatment changed to that used for other types of AML. ref : robbins 10th ed