You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is TRUE statement about nonrenal cause of hypokalemia among the following is: and explain in detail?
Hypokalemia can be due to increased loss. Non renal causes are 1. Gastrointestinal loss (Diarrhea) 2. Integumentary loss (Sweat) MUST KNOW: The loss of K+ in sweat is very low except in extremes of physical exeion Direct gastric losses of K+ is also minimal (Vomiting, NG aspiration) It can lead to hypochloremic alkalosis It lead to persistent kaliuresis due to secondary hyperaldosteronism Celiac disease, ileostomy, villous adenoma, VIPomas, and chronic laxative cause significant hypokalemia Colonic pseudo-obstruction (Ogilvie's syndrome) can lead to hypokalemia from secretory diarrhea Ref: Harrison, Edition-18, page- 352.