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What is Cell cycle specific anti-cancerous drug is? and explain in detail?
Ans. b (Vincristine). (Ref. Harrison Principles of Internal Medicine, 16th ed., 469 Fig. 70.3)CYCLE SPECIFIC ANTICANCEROUS DRUGSS-Phase specific drugsM-Phase specific drugsG,Phase specific drugsHydroxyurea,Methotrexate,Dactinomycin,Cytarabine,5-FU,MercaptopurineThiogauanine,ColchicinesVinca alkaloids and taxols (e.g., vincristine, vinblastine, paclitaxel).Vinca alkaloids (vincristine, vinblastine) inhibit mitotic spindle formation while taxels (paclitaxel) stabilize the mitotic spindles. Thus are known as'Spindle poisons'.Intercalaters: Anthracyclines and actinomycin D.By crosslinking between adjacent guanine in DNA: Cisplatin.By DNA breakage: Bleomycin.