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What is Pharmacokinetic characteristics of propranolol include Vd = 300 L/70 kg, C1 = 700 mL/min, and oral bioavailability f = 0.25. What is the dose needed to achieve a plasma level equivalent to a steady state level of 20 mg/L? and explain in detail?
LD = 300L x 20 mg/L / 0.25 = 6000 mg/0.25 = 24,000 mg or 24 mg Ref:- kd tripathi; pg num:-33