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What is Gastric carcinoma is associated with all EXCEPT and explain in detail?
Gastric carcinoma - mutation loss of function mutation in the tumor suppressor gene CDH1. BRCA2 mutations Mutations of TP53 Loss of function mutation in the WNT signaling pathway (APC gene), gain of function in the gene encoding beta-catenin Loss of function in genes regulating apoptosis(BAX), cell cycle regulators(CDKN2A). C-met and C-erb(ERBB2) are members of K (receptor tyrosine kinase ) family. There is no autoimmune basis for gastric carcinoma. Ref: GENERAL AND SYSTEMIC PATHOLOGY RAMDAS NAYAK, 2nd edition, page 487