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What is Characteristic of mixed connective-tissue disease are all of the following except: March 2005 and explain in detail?
Ans. A: Hypogammaglobulinemia Manifestations of mixed connective-tissue disease (MCTD) can be variable. Most patients experience Raynaud phenomenon, ahralgia/ahritis, swollen hands, sclerodactyly or acrosclerosis, and mild myositis. The following may be revealed by history or physical examination: Raynaud phenomenon Ahralgia/ ahritis Esophageal hypomotility Pulmonary dysfunction Swollen hands Myositis Rash Leukopenia Sclerodactyly Pleuritis/ pericarditis Pulmonary hypeension Membranous glomerulonephritis Lab investigations shows features of inflammation with elevated ESR and hypergammaglobulinemia