You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A 2 year old female child, normal at bih, having normal early development, now presents with microcephaly, regression of acquired language & motor milestone along with abnormal stereotypic hand wringing movements. Most likely diagnosis is? and explain in detail?
Rett syndrome:cause of acquired microcephaly X linked dominant inheritance MC gene involve MECP2 gene MC in females Normal head circumference at bih Deceleration of head growth. Developmental delay followed by loss of purposeful hand movement with development of stereotypic hand wringing movement Asperger syndrome:characterized by significant difficulties in social inheritance and nonverbal communication along with restricted and repetitive patterns of behavior and interest. Metachromatic Dystrophy: lysosomal storage disease that causes progressive demyelination of central (white matter) and peripheral nervous system.