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What is Hirschprung&;s disease true are and explain in detail?
.* It is a congenital, familial condition, occurring in newborn due to the absence of ganglion cells--Auerbach's and Meissner's plexus in anorectum, which may extend proximally either a pa or full length of the colon. * It always involves the anus, internal sphincter and rectum (paly or entirely). * There is narrow, spasmodic, non relaxing pathological segment. * Transitional zone proximal to it contains only few ganglion cells with formation of cone. * Still proximal to it, colon is dilated enormously with hyperaemia, multiple ulcers and hyperophied circular muscle fibers. * It is one of the causes of neonatal intestinal obstruction. * Severe enterocolitis can occur which may be fatal. Perforation, peritonitis and septicaemia can occur. * Often there will be a chronic course of the disease with malnutrition, abdominal distension. ref:SRB &;s manual of surgery,ed 3,pg no-818