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What is Which of the following drugs act by inhibiting granulocyte migration? and explain in detail?
Ans (A) Colchicine(Ref: Goodman and Gilman 13th/702-703)Colchicine is more effective and faster acting than NSAIDs but is used rarely due to its high toxicity.It acts by inhibiting granulocyte migration into the in- flamed joint.It causes metaphase arrest (other drugs causing meta- phase arrest are vinca alkaloids, ixabepilone and taxanes).Most common and dose limiting toxicity is diarrhea.It can also cause kidney damage, myopathy and bone marrow depression.