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What is Which of the following cause an increase in ACh release from the presynaptic neuron? and explain in detail?
Ans. D. Blocking K channels* Potassium channel blocker will cause an increase in ACh release from the presynaptic neuron.* Blockade of presynaptic potassium channels promotes activation of voltage-gated calcium channels leading to the increased release of acetylcholine in the neuromuscular junction. Aminopyridines used in the treatment of Lambe-Eaton myasthenic syndrome acts by this mechanism and improves the muscle strength in the patients