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What is Predisposing factors for gastric ca are - and explain in detail?
Answer 'a' i.e. Atrophic gastritis; 'b' i.e. Hyperplastic Polyp; 'c' i.e. Adenomatous Polyp Achlorhydria associated with pernicious anemia, chronic H. pylori infection, gastrectomies are assoicated with increased risk of gastric cancer probably because reduced acid secretion ours bacterial growth and perpetuation of chronic inflammation with mucosal epithelial cell proliferation and hence increased risk of genomic mutation. Bacterial growth also conves nitrates into nitrites which are a proven carcinogen.