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What is In sickle cell anemia defect is in which chain? and explain in detail?
Ans. (b) b-chain(Ref: 9th/pg 635-636; 8th/pg 645-647)In sickle cell anemia defect is: point mutation in the6th codon of b-globin Q that leadsto there placement of a glutamate residue with a valine residue. QLeading to: Abnormal physiochemical properties(Solubility defect) Q of the resulting sickle hemoglobin (HbS)Promotes the polymerization of deoxygenated haemoglobinLeading to red cell distortionHemolytic anemia, microvascular obstruction, and ischemic tissue damage.