You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which one of the following acts to increase the release of Ca2 from endoplasmic reticulum? and explain in detail?
Ischemia and ceain toxins cause an increase in cytosolic calcium concentration, initially because of the release of Ca2+ from the intracellular stores, and later resulting from increased influx across the plasma membrane.Increased cytosolic Ca2+ activates a number of enzymes, with potentially deleterious cellular effects.These enzymes include phospholipases (which cause membrane damage), proteases (which break down both membrane and cytoskeletal proteins), endonucleases (which are responsible for DNA and chromatin fragmentation), and adenosine triphosphatases (ATPases) (thereby hastening ATP depletion).( Robbins Basic Pathology, 9th edition, page 23 )