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What is Peripheral blood smear examination of a post splenectomy patient would show the presence of: and explain in detail?
In the absence of a functional spleen, nuclear remnants are not culled from the red cells and remain as small homogeneously staining blue inclusions, known as Howell-Jolly bodies. Dohle bodies are light blue-gray, oval, inclusions located in the peripheral cytoplasm of neutrophils seen in infections, burns physical truma etc. Sphere-shaped red blood cells are known as spherocytes. Spherocytes are found in hereditary spherocytosis and autoimmune hemolytic anemia. Hypersegmented neutrophils are seen in vitamin B12 deficiency. Ref: Harrisons principles of internal medicine, 18th edition, chapter: 57