You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A pregnant lady had no complaints but mild cervical lymphadenopathy in first trimester. She was prescribed spiramycin but she was noncompliant. Baby was born with hydrocephalus and intracerebral calcification. Which of these is likely cause ? and explain in detail?
Hydrocephalus and intracerebral calcification can occur in all the four options either commonly (Toxoplasma, CIVIV) or uncommonly (HSV, rubella). See previous explanation.
However, spiramycin in pregnancy is given for toxoplasmosis.
Acute maternal toxoplasmosis is usually asymptomatic, some patients may present with posterior cervical lymphadenopathy, fatigue, lassitude and maculopapular rash.
Spiramycin reduces the risk of congenital infection in acute toxoplasmosis during pregnancy.
As the patient was not compliant with spiramycin, baby developed congenital toxoplasmosis.