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What is A 40 years old patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam can be used for pre-anaesthetic medication in this patient without concern for excessive CNS depression because the drug is: and explain in detail?
(Ref: Katzung 6/e p450) Lorazepam and oxazepam are the benzodiazepines which are excreted from the body by glucuronide conjugation without phase 1 metabolism in the liver. So these can be used safely in hepatic dysfunction.