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What is isolated conjugated hyperbilirubinemia is seen in the following conditions except- and explain in detail?
Gilbe's syndrome is by far the most common inherited disorder of bilirubin metabolism . It is an autosomal recessive trait when caused by a mutation in the promoter region of the gene for UDP-glucuronyl transferase enzyme (UGT1A1), which leads to reduced enzyme expression. It can be inherited in a dominant fashion when there is a missense mutation in the gene. This results in decreased conjugation of bilirubin, which accumulates as unconjugated bilirubin in the blood. The levels of unconjugated bilirubin increase during fasting, as fasting reduces levels of UDP-glucuronyl transferase. Ref Davidson 23e p897