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What is Which of the following is a physiological uncoupler of oxidative phosphorylation: and explain in detail?
Uncoupler: Uncoupler means electron flow (oxidation) is occurring but phoshorylation is not occurring. This will lead to reduced ATP formation as phosphorylation is not occurring. It will stimulate electron transpo in order to produce more ATPs. Thermogenin, a protein present in brown fat, is a natural/physiological uncoupler of ETC. This is responsible for non-shivering thermogenesis. ADDITIONAL EDGE: Other uncouplers of ETC are: