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What is 17 hydroxylase dificiency causes - increase production of and explain in detail?
Deficiency of 17 alpha hydroxylase leads to increased production of aldosterone. Progesterone synthesised from cholestrole is normally acted upon by 21 alpha hydroxylase which is fuher conveed to coicosterone and aldosterone . Some amount of progesterone is channeled to production of coisol and estradiol by the action of 17 alpha hydroxylase through a separate pathway. So in the absence of 17 alpha hydroxylase progesterone is entirely channeled to the production of aldosterone by the action of 21 alpha hydroxylase Reference: Ghai TB of pediatrics 8th edition pg 527 fig 17.11