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What is Which is a selective cyclo-oxygenase-2 inhibitor : and explain in detail?
Ans. is 'c' Nabumetone [Ref: KDT 5th/ P180 (page 464, 4,u/e)[* All the drugs mentioned are cyclo-oxygenase inhibitor (both COX-1 & COX-2 are inhibited)But Nabumetone is a more potent COX-2 inhibitor than COX-1 (a selective COX-2 inhibitor)Other selective COX-2 inhibitors areCelecoxib*Rofecoxib*The risk for gastrointestinal bleeding is less with selective COX-2 inhibitors