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What is Ewings sarcoma arises from - and explain in detail?
Histologically, Ewing's sarcoma has a certain resemblance to primitive neuroectodermal cells, and the tumor arises from such cells.
It is a rare malignancy primarily affecting children and adolescents. It arises mainly in bone and less commonly in soft tissues.
In these, there is a characteristic reciprocal chromosomal translocation, which leads to an in-frame fusion between the EWS gene and one of the ETS family gene members.