You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which one of the following diseases or conditions predisposes a patient to acetaminophen toxicity? and explain in detail?
The enzyme that produces the toxic NAPQI, CYP2E1, is induced by alcohol. Diabetes (either type 1 or type 2) will not lead to an induction of CYP2E1, nor will pernicious anemia (intrinsic factor deficiency) or obesity (in the absence of alcoholism). Chronic alcoholics have a reduced tolerance for acetaminophen because of the induction of the MEOS, which results in increased levels of CYPE21.