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What is Mechanism of action trimetazidine is ? and explain in detail?
Ans. is'd'i.e.,Inhibiting mitochondrial LC3-KAT(Ref: KDTh/e p. 554)Trimetazidine:This antianginal drug acts by non hemodynamic mechanisms.The mechanism of action of trimetazidine is unceain, but it may improve cellular tolerance to ischaemia by inhibiting mitochondrial long chain 3-ketoacyl-CoAthiolase (LC3-KAT) a key enzyme in fatty acid oxidation- thereby reducing fatty acid metabolism and increasing glucose metabolism in myocardium.