You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The first step in the initiation of primary hemostasis for clot formation is? and explain in detail?
Steps in hemostasis at the site of injury
i) Vasoconstriction
• Immediate hemostasis following injury is achieved by brief arteriolar vasoconstriction. It is due to the reflex neurogenic mechanism. This effect is transient.
ii) Primary hemostasis
• It is achieved by the formation of the primary hemostatic plug (platelet plug). Following an injury to endothelium, the thrombogenic subendothelial matrix is exposed and allows the platelets to adhere with collagen of ECM. These platelets are activated and recruit other platelets by their secretions.
iii) Secondary hemostasis
• Activation of coagulation (clotting) system leads to the formation of the secondary hemostatic plug (definitive plug or fibrin clot) which is composed of fibrin, platelets, RBCs, and thrombin.
iv) Dissolution of clot
• Activation of the fibrinolytic system results in dissolution of the clot.