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What is Low-density lipoproteins (LDL) represents a final stage in the catabolism of VLDL. Which of the following receptors are present in liver for uptake of LDL? and explain in detail?
The liver and many extrahepatic tissues express the LDL (apo B-100, E) receptor. It is so designated because it is specific for apo B-100 but not B-48, and also takes up lipoproteins rich in apo E. Approximately 30% of LDL is degraded in extrahepatic tissues and 70% in the liver. The LDL (apoB-100, E) receptor is defective in familial hypercholesterolemia. Ref: Botham K.M., Mayes P.A. (2011). Chapter 25. Lipid Transpo & Storage. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.