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What is Morphologically diagnostic feature of cancer cells - and explain in detail?
Ans. is 'b' i.e., T Mitotic activity Benign Vs malignant neoplasm Criteria o Differentiation o Growth limits o Growth rate o Invasivness o Metastasis o Mitotic figures o Cell size & shape o Nuclear to cytoplasmic ratio o Stroma o Cell orientation (Polarity) o Nuclear chromatin o Blood supply Benign Well differentiated Limited, encapsulated Usually slow Non-invasive Non-metastatic Rare Uniform Normal (I :4 to 1:6) Abundant Normal Normal Adequate Malignant (cancer) Well differentiated to undifferentiated (anaplastic) Unrestricted, no surrounding capsule Often rapid, but can be slow Invasive Metastatic Atypical, with increased number Pleomorphism Increased (1:1) Often scanty Disorganized (loss of polarity) Hyperchromatasia Often inadequate thus areas of necrosis