You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is PNH is associated with all of the following conditions, except : and explain in detail?
Answer is D (Increased LAP scores) PNH is associated with a decreased Leukocyte Alkaline phosphase (LAP) score PNH: Paroxysmal Nuctunal haemoglobinuria: Review PNH is an Acquired Q Intracarpuscular (--) disorder, acquired at stern cell level (-) by loss characterised by undue sensitivity of red blood cell's membrane to complement (--) Common manifestations: PNH : Three common manifestation Hemolytic Anemia Venous Thrombosis Deficient Hematopoesis Probably due to defect at stem cell level Because of increased activation of Activation of complement indirectly Pancytopenia/Aplastic anemia complement and complement stimulates platelet aggregation and - Granulocytes mediated destruction hypercoagulability (thus thrombosis - Thrombocytes (thrombocytopenia) * despite thrombocytopenia) HemoglobinemiaQ Hemoglohinuriae HemosiderinuriaQ Elevated LDH Q Why is it called Paroxysmal Nocturnal haemoglobinuria? Basis : Acidification enhances activity of complement During night when one sleeps (noctunal) --> Relative Hypoxia --> Acidosis --> Enhanced complement activity Paroxysm of Haemoglobinuria identified by --> Complement mediated destruction of red blood cells passage of brown urine in morning. Red Cell Membrane is deficient in two factors which result in increased activation of complement 1. DAF Q :Decay accelerating factor that activates decay of complements 2. MIRL CD 59 : inhibits membrane attack complex