You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Increase in P50 results in change in oxygenation curve, which is due to decrease in and explain in detail?
Hb-O2 dissociation curve shift to left indicates more affinity of Hb to O2 and thus less delivery of O2 to tissues. 
Hb-O2 dissociation curve shift to right indicates less affinity of Hb to O2, and thus more delivery of O2 to tissues. 
When P50 increases, the affinity of Hb to O2 decreases, or there is a shift of the curve to the right. 
Among the given options, the only decrease in pH causes a right shift of the curve. All others when decreased cause shifts to left.