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What is Menke's kinky (Steely) hair disease occurs due to: and explain in detail?
Menke's kinky hair disease- X-linked defect in intestinal absorption of copper. Mutation in ATP7A gene. Low levels of copper and ceruloplasmin. C/F- Progressive cerebral degeneration, growth retardation Sparse brittle hair Scurvy-like bone changes Anemia and neutropenia Failure to thrive Pili toi, trichorrhexis and monilethrix may occur.