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What is Which of the following drug combination is supraadditive and explain in detail?
Additive: Effect of drug A + B = effect of drug A + effect of drug B Aspirin + paracetamol as analgesic/ antipyretic Nitrous oxide + halothane as general anaesthetic Amlodipine + atenolol as antihypeensive Glibenclamide + metformin as hypoglycaemic Ephedrine + theophylline as bronchodilator Supra additive : Effect of drug A + B > effect of drug A + effect of drug B Acetylcholine + Physostigmine Inhibition of break down Levodopa + carbidopa/ Inhibition of peripheral metabolism benserazide Adrenaline + cocaine/ desipramine Inhibition of neuronal uptake Sulfamethoxazole + trimethoprim Sequential blockade Antihypeensives enalapril+ hydrochlorothiazide: Tackling two contributoryfactors