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What is The procedure done in cases of clinical suspicion of amyloidosis is and explain in detail?
The diagnosis of amyloidosis is confirmed by the presence of amyloid deposition in tissue biopsy specimen. A skin punch biopsy from the lesion is the preferred confirmatory procedure. The next best choice is needle biopsy from the abdominal subcutaneous fat from the clinically normal-appearing skin may be performed. The skin and abdominal fat biopsy provide positivity in 86% to 95% of amyloidosis cases, depending upon the type of amyloidosis.In case of clinical suspicion, congo red staining of abdominal fat or other tissue is advised.Ref: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 137 Amyloidosis; Page no: 720