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What is The TRUE statement about B cell Prolymphocytic leukemia is: and explain in detail?
B Cell Prolymphocytic Leukemia Malignancy of medium-sized, round lymphocytes with a prominent nucleolus and light blue cytoplasm It usually does not cause adenopathy. The median age of patients is 70 years The clinical course can be rapid. The cells express surface IgM and B cell markers (CD19, CD20, CD22). CD23 is absent. Fludarabine and cladribine and combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone, or CHOP) are effective. Splenectomy can produce palliation of symptoms but little impact on the course of the disease. Ref: Harrison, E-18, e-21.