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What is Most abundant in bone and explain in detail?
Hydroxyproline is catabolized more or less similar to proline. It is confer strength to fibrous proteins like collagen , elastin, keratin.etc.In vitamin C deficiency hydroxyproline synthesis is reduced , causing strength of fibers , leading to scurvy. The excretion of hydroxyproline in urine is increased in tumours infiltrating bones and in diabetic patients due to enhanced rate of protein catabolism. REFERENCE: DM.VASUDEVAN.TEXTBOOK SEVENTH EDITION ;PAGE NO : 244