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What is Which of the following is the only hemolytic anaemia caused by acquired intrinsic defect in the cell membrane: and explain in detail?
PNH is the only hemolytic anemia caused by an acquired intrinsic defect in the cell membrane. 
The stem cells of the bone marrow acquire mutations in Phosphatidyl inositol glycan A (PIGA) gene. 
The triad of hemolysis, pancytopenia and thrombosis is unique to PNH. 
Thrombosis is the leading cause of disease related death in PNH.