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What is Progesterone pills act by which of the following mechanism? and explain in detail?
Ans. a (Thickening of cervical mucus). (Ref. Dutta, Obstetrics.4th/586, William Obstetrics 21st/1531)MINIPILLS (Progesterone Only Pills)# E.g., levenorgestrol 30 meg, norethistrone 350 meg.- They act by thickening the cervical mucus.- It is very useful as a emergency contraception.# Advantages- Side-effects attributed to estrogen are totally eliminated.- Lactational pill- No "on and off " regimen.- May be used by patients witha) Hypertension, Fibroid, DM,b) Epilepsy, Smoking, Thromboembolism.- Ideal for patients with sickle cell disease as progesterone is thought to treat bony crises.# Side-effects- Amenorrhea, at times breakthrough bleeding- All side effects are attributed to progesterone may be evident- Simple cyst of ovary# Failure rate = 0.5-2 HWY.