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What is A 6-month-old baby with severe pallor and hepatosplenomegaly. Similar history is present in a sibling. Investigation of choice: and explain in detail?
b. Hb electrophoresis(Ref: Nelson's 20/e p 2323-2325, Ghai 8/e p 334-335)Presence of pallor and hepatosplenomegaly at 6 months of age with a positive family history indicates towards thalassemia major, which can be diagnosed by Hb electrophoresis.