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What is Mutation not seen in diffuse type of gastric cancer? and explain in detail?
Hereditary diffuse gastric cancer is an inherited form of gastric cancer. Patients with this disorder, resulting from a gene mutation for the cell adhesion molecule E-cadherin, have an 80% lifetime incidence of developing gastric cancer. Inactivation of the tumor suppressor genes p53 and p16 has been repoed in diffuse and intestinal-type cancers. Adenomatous polyposis coli gene mutations tend to be more frequent in intestinal-type gastric cancers. Sabiston 20e pg: 1240.