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What is In congenital junctional epidermolysis bullosa , defect is seen in? and explain in detail?
EB comprises a group of genetically determined skin fragility disorders characterized by blistering of the skin and mucosae following mild mechanical trauma. Congenital epidermolysis bullosa of 3 types: 3 types Defect 1. Epidermolysis Bullosa Simplex 2. Epidermolysis Bullosa Junctional 3. Epidermolysis Bullosa Dystrophicans K5 / 14Q LamininQ Collagen-7Q Cogentinal is DIF Negative because no antibodies. Acquired epidermolysis bullosa: Ab against NCD (non collagenous domain) of Collagen 7 therefore DIF Positive