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What is Methemoglobinemia is associated with: and explain in detail?
A unique systemic side effect associated with a specific local anesthetic is the development of methemoglobinemia after the administration of large doses of prilocaine. In general, 600-mg doses are required for the development of clinically significant levels of methemoglobinemia in adults. Ref: Miller's anesthesia-7th ed, Chapter 30.