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What is A genetic disorder renders fructose 1,6 -- bisphosphates in liver less sensitive to regulation by fructose 2,6 -- bi-phosphate. All of the following metabolic changes are observed in this disorder except: and explain in detail?
Ans. A. Level of fructose 1,6--biphosphate is higher than normalFructose 2,6 - biphosphate acts to decrease the activity of fructose 1,6 - bisphosphates. When the enzyme becomes less sensitive to regulation, the inhibitory effect is lost and the enzyme activity increases. The following effects are observed:a. Level of fructose 1,6 -- biphosphate decreasesb. Pyruvate is used up for glucose synthesisc. ATP is used up for glucose synthesis