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What is Cytogenetic studies in a 70-year-old woman with chronic myelogenous leukemia (CML) demonstrate a t(9;22) chromosomal translocation. Which of the following best explains the role of this translocation in the pathogenesis of leukemia in this patient? and explain in detail?
Philadelphia chromosome is the best-known example of an acquired chromosomal translocation in a human cancer It is found in 95% of patients with CML. The c-abl protooncogene on chromosome 9 is translocated to chromosome 22 The c-abl gene and bcr region unite to produce a hybrid oncogene that codes for an aberrant protein with very high levels of tyrosine kinase activity, which generates mitogenic and antiapoptotic signals.