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What is Which of the following statements is true about the G-protein-coupled receptor (GPCR)? and explain in detail?
G protein can be either stimulatory (Gs) or inhibitory (Gi). Stimulatory or inhibitory activity resides in the a subunit. G-protein coupled receptor (GPCR) are cell membrane receptors that span the membrane 7 times hennce called seven helix or serpentine receptors. Upon ligand binding to GPCR, a conformational change activates the G protein (present inside the cell). Heterotrimeric G protein (3 subunits a,b,g. Couple the cell surface receptor (GPCR) to catalytic units that catalyse the intracellular formation of second messenger F. In resting-state a subunit is bound to GDP. The intrinsic GTPase activity of the subunit then conves GTP to GDP, and this leads to reassociation of the a with the b-g subunit and termination of effector activation. Ref: Guyton and Hall 13th edition Pgno: 931