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What is Patient diagnosed as squamous cell intraepithelial lesion. Which of the following has the highest risk for progression to carcinoma? and explain in detail?
Cervical intraepithelial neoplasia (CIN grades I-III) and squamous intraepithelial lesions (SIL) are dysplastic changes in the cervical epithelium that are a precursor to malignancy (i.e., squamous cell carcinoma of the cervix) and are the result of infection with HPV. High-grade SIL and CIN II-III lesions are caused by HPV types 16, 18, 31, 33, 35, 39, 45, and 52, and have a high risk for progression to an invasive squamous cell carcinoma. Low-grade SIL and CIN I lesions are caused by HPV types 6, 11, 42, and 44, and have a low risk for progression to squamous cell carcinoma. Ref: Kemp W.L., Burns D.K., Brown T.G. (2008). Chapter 17. Pathology of the Male and Female Reproductive Tract and Breast. In W.L. Kemp, D.K. Burns, T.G. Brown (Eds), Pathology: The Big Picture