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What is Which of the following diuretic can be given in mild to moderate hypeension? and explain in detail?
Ans: C. Thiazide diureticThiazide diuretics :Given in mild to moderate hypeension.Low-dose thiazide diuretics used alone or in combination with other antihypeensive drugs.Safe, efficacious, inexpensive & reduce clinical events. MOA:Inhibits Na/Cl- pump in DCT a Increases sodium excretion.In long term - Acts as vasodilators.Provide additive blood pressure-lowering effects (On combination with beta blockers, ACE-I, ARBs).Drug of Choicein HypeensionConditionDrug of ChoiceHypeensionThiazidesHypeension with BPHPrazosinHypeension with diabetes mellitusACE inhibitorsHypeension with ischemic hea disease (angina)Beta-blockersHypeension with chronic kidney diseaseACE inhibitorsHypeension in pregnancyAlpha-methyldopaHypeensive emergenciesNicardipine + EsmololHypeensive emergencies in cheese reactionPhentolamineHypeensive emergencies in clonidine withdrawalPhentolamineHypeensive emergencies in aoic dissectionNitroprusside + EsmololHypeensive emergencies in pregnancyLabetalol(Ref: Harrison 19/e p1623).