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What is Which of the following is a pro kinetic drug- and explain in detail?
Ans. is 'a' i.e., Domperidone Gastrokinetk (prokinetic drugs)o These are the drugs which promote gastrointestinal transit and speed gastric emptying by enhancing coordinated propulsive motility.o Prokinetic drugs are - Metoclopramide, Domperidone, Cisapride, Mosapride, Tegaserod, renzapride, prucatopride.Pathophysiology of gastrokinetic drugs:o Acetylcholine is the major neurotransmitter in the GIT which is responsible for the peristaltic movement,o Its secretion is affected by other neurotransmitter also -1. Activation of prejunctional excitatory 5-HT, receptors increases the release of Ach.2. Activation of prejunctional inhibitory D2 and 5-HT. receptors inhibits the release of Ach.o So, prokinetic drugs can act by -1. 5HT4 agonistic activity2. D2 and 5-HT3 antagonistic activityo Both these action will increase the release of Ach and there by motility of GIT.