You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Haptaglobin levels are decreased in: and explain in detail?
Answer is D (All of the above) Decreased haptaglobin levels may occur in all cases of hemolysis. Although decreased haptaglobin levels are more characteristic of intravascular hemolysis, decreased levels are also seen in cases of extravascular hemolvsis. Heptaglobin levels and hemolysis (Hematology for Student's by Mackinney (2003)/78, 79 Normal plasma contains haptoglobin, an a2- globulin that can bind free haemolglobin During intravascular hemolysis as levels of free haemoglobin rise significantly, the levels of serum haptoglobin are observed to be very low or absent Even in Extravascular hemolysis, enough haemoglobin levels leaks out of the macrophages to bind with and deplete haptaglobin Therefore A low serum haptaglobin concentration is a good test of hemolysis butt is not specific for intravascular hemolysis. Parameter Extravascular hemolysis Intravascular hemolysis Haptaglohin Low Very low/Absent