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What is Acid phosphatase is specific to which of the following cells- and explain in detail?
Acid phosphatase is found in all hematopoietic cells, but the highest levels are found in macrophages(monocyte) and osteoclasts. A dot-like pattern is seen in many T lymphoblasts Taarate resistant acid phosphatase (TRAP) is seen in osteoclasts and Hairy cell leukaemia. Positive TRAP staining may be seen in activated T lymphocytes, macrophages, Gaucher cells, mast cells and some marginal zone lymphomas. Acid phosphatase is useful for lymphoblasts which are seen in ALL TRAP - is a Biochemical marker of bone resorption Prostatic acid phosphatase marker for prostatic cancer Taarate resistant acid phosphatase (TRAP) is an impoant tool in the differential diagnosis of hairy cell leukaemia ref Robbin 9/e p603-604