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What is Diffuse cutaneous systemic sclerosis is characterised by: and explain in detail?
Diffuse cutaneous SSc is associated with 1. Progressive skin induration 2. Early pulmonary fibrosis and acute renal involvement. Limited cutaneous SSc have 1. Long-standing Raynaud's phenomenon before other manifestations of SSc appear. 2. Skin involvement remains limited to the fingers (sclerodactyly) A subset of patients with limited systemic sclerosis have a) calcinosis cutis, b) Raynaud's phenomenon, c) esophageal dysmotility, d) sclerodactyly e) telangiectasia (Termed CREST syndrome) Long term prognosis is poor in diffuse variety than limited systemic sclerosis. Ref: Harrison, E-18, P- 2757.