You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Muscle rigidity due to opioids is because of their effect on? and explain in detail?
Ans. is 'a' i.e., mu o Opioids appear to produce their physiologic effects by binding to at least three types of opioid receptors, the mu GO, delta (b), and Kappa (K). Muscle rigidity occurs after administration of supra-analgesic doses of potent mu preferring agnoists like a fentaniL "The present data demonstrate that opiate-induced muscle rigidity is primarily due to the activation of central mu receptors, and supraspinal delta and kappa receptors may attenuate this effect"