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What is Which one has least mineralocoicoid activity? and explain in detail?
Coisol (Hydrocoisone) has primary glucocoicoid action and has significant mineralocoicoid activity. Prednisolone has glucocoicoid activity but at high doses fluid retention does occur. Fludrocoisone is a potent mineralocoicoid having very less glucocoicoid activity. Methylprednisolone is more selective glucocoicoid with very less mineralocoicoid activity (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition - Page No - 281)