You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Amyloidosis is most commonly seen in DM - and explain in detail?
(C) (Type II DM) (252- Robbins 8th) (155 - Robbins - Basic pathology 9,h)* The two best example of localized amyloidosis are Alzheimer's disease and Type II DM* In type II DM it is the islet amyloid polypeptide (AIAPP) also known as Amylin.* Amyloidosis in fundamentally a disorder of protein misfolding**.Classification of AmyloidosisClinicopathologic CategoryAssociated Disease (s)Major Fibril ProteinChemically Related Precursor ProteinSystemic (Generalized) AmyloidosisImmunocyte dyscrasis with amyloidosis (primary amyloidosis)Multiplex myeloma and other monoclonal plasma cell proliferationsALImmunoglobulin light chains, chiefly l typeReactive systemic amyloidosis (secondary amyloidosis)Chronic inflammatory conditionsAASAAHemodialysis-associated amyloidosisChronic renal failureAb2mb2-MicroglobulinHereditary AmyloidosisFamilial Mediterranean fever AASAAFamilial amyloidotic (severe types) ATTRTransthyreinSystemic senile amyloidosis ATTRTranshyretin Localized Amyloidosis Senile cerebralAlzheimer diseaseAbAPPEndocrine Medullary carcinoma of thyroid A CalCalcitoninIslets of LangerhansType 2 diabetesAIAPPIslet amyloid peptideIsolated atrial amyloidosis AANFAtrial natriuretic factor* On histologic examination, the amyloid deposition is always extracellular and begins between cells.* Kidney - amyloid deposits are found principally in the glomeruli. Liver - amyloid deposits first appear in the space of Disse. They do not provoke an inflammation response.* Protein involved in inter cellular connection is - connexin.* MC employed stain for amyloidosis is - Congored with polarized light*** "Pinch" purpura is diagnostic of systemic primary amyloidosis.