You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The vasodilator involved in autoregulation of the coronary blood flow is: and explain in detail?
NO and adenosine both fit as the probable candidates. However, single best response would be adenosine, and NO could be taken as the mediator of the adenosine action. As per the Berne's hypothesis: When myocardial O2 demand increases (as during increased hea rate) -> increased breakdown of ATP in the myocardial cells -> ATP conveed to ADP, AMP, and finally adenosine -> adenosine leaks out of the cells, reaches the vessels, and causes vasodilation & increases blood flow. At low concentrations ~ adenosine acts the release of NO At higher concentrations ~ adenosine acts directly on the ATP-sensitive K+ channels in the VSMC of the coronary vessels.