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What is All of the following statements are true regarding lipoproteins, EXCEPT: and explain in detail?
LDL receptor are present in all cells most abundant in hepatic cells and adrenal coex. When apo B100 in LDL bind to LDL receptor, receptor-LDL complex is internalized by endocytosis. A deficiency of functional LDL receptors causes a significant elevation in plasma LDL and therefore increase in plama cholesterol. Thus increased blood cholesterol will be associated with a decrease in LDL receptors and not with an increase in the receptors. Ref: Textbook of Biochemistry By DM Vasudevan, 3rd Edition, Pages 138-40 ; Lippincott Biochemistry, 2nd Edition, Page 215