You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Toxic shock syndrome is Staphylococcus infection is due to and explain in detail?
Toxic shock syndrome is a potentially fatal multisystem disease caused by TTST type 1(formerly known as enterotoxin type F or pyrogenic exotoxin C) is most often responsible, though enterotoxins B or C may also cause the syndrome. Staphylococcal enterotoxins and TSST-1 are superantigens which are potent activators of T lymphocytes. Being V beta-restricted T cell mitogens, such superantigens stimulate very large numbers of T cells, without relation to their epitope specificity. This leads to an excessive and dysregulated immune response, with the release of cytokines interleukins 1 and 2, tumor necrosis factor and interferon gamma. This explains the multisystem involvement and florid manifestations in staphylococcal food poisoning and TSS. Ref: Textbook of Microbiology; Ananthanarayanan and Panicker; 10th Edition; Page No: 204