You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Drug of choice for plague is: and explain in detail?
TETRACYCLINES: These are a class of antibiotics having a nucleus of four cyclic rings. Tetracyclines are the first choice drugs. despite development of resistance by many organisms in: a)venereal diseases chlamydial non specific urethritis/endocervicitis: 7 day doxycycline treatment is as effective as azithromycin single dose. * Lymphogranuloma venereum: resolves in 2-3 weeks * Granuloma inguinale:Due to Calymm granulomatis: a tetracycline administered for 3 weeks is the most effective treatment. b) Atypical pneumonia: due to Mycoplasma pneumoniae: duration of illness is reduced by tetracycline therapy. Psittacosis is treated in 2 weeks by tetracyclines. &; c) cholera: Tetracyclines have adjuvant value by reducing stool volume and limiting the duration of diarrhoea. d)brucellosis: Tetracyclines are highly efficacious; cause rapid symptomatic relief; therapy of choice is doxycycline 200 mg/ day + rifampin 600 mg/ day for 6 weeks. Gentamicin may be combined with doxycycline in acute cases. e)plague: Tetracyclines are highly effective in both bubonic and pneumonic plague. They are preferred for blind/ mass treatment of suspected cases during an epidemic, though streptomycin often acts faster. (j) Relapsing fever* due to Borrelia recurrentis responds adequately. (g) Rickettsial infections: typhus, rocky mountain spotted fever, Q fever, etc. respond dramatically. Chloramphenicol is an alternative. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:714,715