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What is Half Life of digoxin is and explain in detail?
Ref-KDT 7/e p55 Digoxin and digitoxin are the main digitalis products. Digoxin is absorbed quickly from the gastrointestinal tract with a bioavailability of between 75% and 95%. It is eliminated primarily through kidneys; therefore, it has a half-life of 36-48 hours in patients who have normal kidney function and 3.5-5 days in patients who are anuric. The reference range for digoxin is as follows: 0.8-2 ng/mL (1.2-2 nmol/L) Half-life: 36 hours Toxic level: more than 2 ng/mL