You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Hanup disease is related to ? and explain in detail?
Hanup disease It is an inherited disorder in the metabolism of tryptophan. It is due to defective transpo of tryptophan and other neutral amino acids in the intestine and kidney. This results in deficiency of tryptophan leading to decreased synthesis of niacin and serotonin. Thus there are pellagra (niacin deficiency), neurological symptoms (serotonin deficiency) and amino aciduria due to defective transpo of amino acids in kidney.