You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Chronic granulomatous disorder is due to defect in - and explain in detail?
Chronic granulomatous disease is a fatal genetic disorder in which there is deficiency of NADPH oxidase. In these patients, leucocytes phagocytose invading bacteria normally but are unable to kill ingested micro organisms because engulfment of bacteria is not followed by activation of oxygen dependent killing mechanism. Reference : Baveja text book of microbiology, 4th edition, Pg no: 153 <\p>