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What is The molecule which is the initiator of cataract formation in the lens of the eye and whose 1-phosphate derivative is responsible for liver failure is and explain in detail?
Ans. (b) GalactitolRef: American Academy of Ophthalmology, BSCS, Section 11/ p. 61In Classic Galactosemia (AR) defect in galactose 1-phosphate uridyltransferase (Gal-1-PUT), results in inability to convert galactose to glucose.Galactose accumulates with further metabolic conversion to galactitol/dulcitol (responsible for cataract) and galactose -1- phosphate (responsible for liver failure).