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What is The given pattern of EEG found in: and explain in detail?
Ans. (b) Creutzfeldt - Jakob diseaseRef: Harrisons Principle of Internal Medicine 20th Ed; Page No- 3059* Periodic sharp wave complex in EEG seen in Creutzfeldt - Jakob disease.Creutzfeldt - Jakob disease (CJD)* CJD is caused by prions, transmissible protein particles.* CJD patient is younger than in Alzheimer.* Rapidly progressive dementia and the presence of myoclonus are most common manifestation.* Although the EEG is abnormal, the most accurate diagnostic test is a brain biopsy.* Pathological Findings: PrPSC deposition, panlaminar spongiosis* CSF shows a 14-3-3 protein. The presence of the 14-3-3 protein spares the patient the need for brain biopsy.Abnormal Waveforms in EEGHepatic encephalopathy* Triphasic wavesHerpes simplex encephalitis* Periodic lateralized epileptiform discharge.* Notice the repetitive burst of activity over temporal area.* In Herpes simplex encephalitis, which mainly affects the temporal lobe, EEG shows Periodic lateralized epileptiform discharge over the temporal lobe.GTCS* Generalized repetitive sharp activity with synchronicity in all leads.