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What is Trypsin cleaves carboxy terminal of : and explain in detail?
Trypsin cleaves carboxy terminal of Basic amino acids (Arginine, Lysine). EXTRA READING ON THIS TOPIC Serine proteases: * Proteolytic enzymes with serine at their active site. * Amino acid triad in the active site of serine proteases - Serine, Histidine, Aspaate. Examples of serine proteases: Chymotrypsin, Trypsin, Elastase, Thrombin, Plasmin, Complements, Factors X and XI Serine Proteases differ in substrate specificity Chymotrypsin: Cleaves at Carboxy terminal of bulky Hydrophobic amino acids (Tryptophan, Tyrosine, Phenylalanine) Elastase: Cleaves at Carboxy terminal of small Neutral amino acids e.g. Glycine, Alanine