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What is An 18 years old girl presents with primary amenorrhea. On evaluation, she was having a karyotype of 45X0 and infantile uterus. What should he done next? and explain in detail?
Ans. d. Bilateral gonadectomyHistory of primary amenorrhea, karyotype of 45X0 & infantile uterus is suggestive of Turner's syndrome. Approximately 5% of women with Turner's syndrome have a karyotype with Y chromosome (45X/46XY). It is impoant to identify' a Y chromosome because affected individuals are at significant risk of gonadoblastoma (20 to 30%). Therefore, prophylactic gonadectomy should be performed.