You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Antiepileptic effect of phenytoin is increased by all of the following except: and explain in detail?
Sucralfate INTERACTIONS Phenobarbitone competitively inhibits phenytoin metabolism, while by enzyme induction both enhance each other's degradation. Cabamazepine and phenytoin increases each other's metabolism. * Valproate displaces protein bound phenytoin and decreases its metabolism: plasma level of unbound phenytoin Increases. * Chloramphenicol, isoniazid, cimetidine, dicumarol and warfarin inhibit phenytoin metabolism & can precipitate its toxicitiy. Phenytoin induces microsomal enzymes and increase degradation of steroids (failure of oral contraceptives), digitoxin, doxycycline, theophyline, * A number of acidic drugs displace it from protein binding sites but this also enhances phenytoin clearance - concentration of free form does not change much. * Sucralfate binds phenytoin in g.i. tract and decreases its absorption.