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What is Action of renin: March 2013 and explain in detail?
Ans. C i.e. Conves angiotensiogenogen to angiotensin I Renin/Angiotensinogenase It is an enzyme that paicipates in the body's renin-angiotensin system (RAS) -- also known as the renin-angiotensinaldosterone axis--that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and aerial vasoconstriction. Thus, it regulates the body's mean aerial blood pressure. The renin enzyme circulates in the blood stream and breaks down (hydrolyzes) angiotensinogen secreted from the liver into the peptideangiotensin I. Angiotensin I is fuher cleaved in the lungs by endothelial-bound angiotensin-conveing enzyme (ACE) into angiotensin II, the most vasoactive peptide.