You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Most impoant prognostic indicator for renal cell carcinoma and explain in detail?
Impoant prognostic factors for cancer-specific survival in patients with nonmetastatic RCC include specific clinical signs or symptoms, tumor-related factors, and various laboratory findings . Overall, tumor-related factors such as pathologic stage,tumor size, nuclear grade, and histologic subtype have the greatest utility on an independent basis. However, an integrative approach, combining a variety of factors that have proved to have independent value on multivariate analysis, appears to be most powerful Pathologic stage has proved to be the single most impoant prognostic factor for RCC ref : Campbell-Walsh 11th ed , chapter 57 , pg no :- 1339