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What is Which of the following is an effect of dinitrophenol on oxidative phosphorylation? and explain in detail?
Mechanism of Action of DNP as uncoupler Dinitrophenol (DNP) a potent uncoupler is amphipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation. Note: DNP was used for weight loss. But it was discontinued due to hypehermia and other side effects. Inhibitors of electron transpo chain and oxidative phosphorylationRef: MN Chatterjea Textbook of Medical Biochemistry, 8th Edition, Page no: 146