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What is In a pregnant lady with hyperthyroidism , the safest drug to be used is - and explain in detail?
Ans. is 'a' i.e., Propylthiouracil * Propylthiouracil is the DOC for hyperthyroidism in pregnancy.* Methimazole and carbimazole used in early pregnancy have been associated with esophageal and choanal atresia, aplasia cutis, and fetal agranulocytosis.* Graves' disease is the MC cause of hyperthyroidism in pregnancy.* Hashimoto's thyroiditis is the MC cause of hypothyroidism in pregnancy.* Complications associated with both hypo- and hyperthyroidism in pregnancy:1) Recurrent first trimester abortions2) IUGR3) Increased risk of preeclampsia4) Abruption5) Stillbirths, hydrop fetalis6) Preterm labor* Hypothyroidism is also associated with cretinism.