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What is Which one of the following is best associated with Lumefantrine ? and explain in detail?
Lumefantrine is a fluorene arylaminoalcohol derivative, it has marked blood schizonticidal activity against a wide range of plasmodia. So it is used as an antimalarial drug. It exes its antimalarial effect by interacting with heme, a degradation product of hemoglobin metabolism. Ref: Malaria Control in Complex Emergencies: An Inter-agency Field Handbook By World Health Organization, Page 77; Harrison's Principles of Internal Medicine, 18th Edition, Chapter 26