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What is All of the following are causes of 'propoionate sho stature' EXCEPT? and explain in detail?
Osteogenesis imperfecta is one of the causes of dispropoionate sho stature, where the limbs are mainly involved, as compared to trunk. Osteogenesis imperfecta: MC cause of multiple fractures in childhood. Autosomal dominant Defected type 1 collagen. C/F: Bone shape- not maintained. Deformed bones, fractures in different areas & different stages of healing. Blue sclera Deafness Dentigerous imperfecta Rx: Gene therapy