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What is Vancomycin is obtained from and explain in detail?
Vancomycin is produced by Streptomyces orientalis. It is poorly absorbed from the intestine. Vancomycin is markedly bactericidal for staphylococci, some clostridia, and some bacilli. The drug inhibits early stages in cell wall peptidoglycan synthesis. Vancomycin is markedly bactericidal for staphylococci, some clostridia, and some bacilli. The drug inhibits early stages of cell wall peptidoglycan synthesis.Undesirable side effects are thrombophlebitis, skin rashes, nerve deafness, leukopenia, and perhaps kidney damage when used in combination with an aminoglycoside.Ref: Chapter 28; Jawetz Medical Microbiology; 27th edition; Antimicrobial Chemotherapy; Page no: 388