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What is Which one of the following can be a homologous substitution for isoleucine in a protein sequence? and explain in detail?
Ans. C. ValineHomologous substitutions are those which don't affect the function. Valine is an amino acid with aliphatic side chain and isoleucine also has aliphatic side chaina. Methionine is a Sulphur containing amino-acid and will not be a homologous substitution for isoleucineb. Aspartic acid has an acidic side chain and will not be a homologous substitution for isoleucinec. Valine has aliphatic side chain and will be a homologous substitution for isoleucined. Arginine has a basic side chain and will not be a homologous substitution for isoleucine