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What is most impoant cell damage in pathogenesis of ARDS is and explain in detail?
RESPIRATORY DISTRESS SYNDROME (ARDS) * Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting into the blood. * Acute respiratory distress syndrome was first described in 1967 by Ashbaugh and colleagues. * ARDS is also referred with variety of terms like * Stiff Lung * Shock lung * Wet lung * Post traumatic lung * Adult respiratory distress syndrome * Adult hyaline membrane disease * Capillary leak syndrome & * Congestive atelectasis. ARDS - PATHOGENESIS Insult (direct or indirect) =>Activation of inflammatory cells & mediators =>Damage to alveolar capillary membrane =>Increased permeability of alveolar capillary membrane =>Influx of protein rich edema fluid and inflammatory cells into air spaces =>Dysfunction of surfactant ref : robbins 10th ed