You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Curshmann's crystals are seen in ? and explain in detail?
Ans. is 'a' i.e., Bronchial asthma Pathology of Asthma Gross ? Lungs are overdistended because of overinflation and there may be small area of atelactasis. The most striking macroscopic finding is occlusion of bronchi and bronchioles by thick tenacious mucus plugs. Histology ? Characterized by presence of numerous eosinophils and neutrophils. Curschman spiral - Whorls of shed epithelium in mucus plugs. Charcot -leyden crystals - Collection of crystalloids made up of eosinophilic membrane protein. The other characteristic histological finding of Asthma is collectively called Airway remodelling, it includes - Thickening of the basement membrane of the bronchial epithelium. Edema and an inflammatory infiltrate in the bronchial walls with a prominence of eosinophils and mast cells. An increase in the size of submucosal glands. Hyperophy of bronchial wall muscle. The "airway remodelling" contributes to airflow obstruction.