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What is Which of the following is defective in renal glycosuria: and explain in detail?
Renal Glycosuria (also called Familial Renal Glucosuria or Glycosuria ) Blood glucose is normal, But still Glucose appears in urine. It is due to defect/mutation in SGLT-2, which is major glucose transpoer (90% glucose reabsorption) present in kidneys for the reabsorption and transpo of Glucose (see fig below). Mutation in SGLT-1 (10% glucose reabsoption) leads to glucose-galactose malabsorption