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What is Expected change in Vitamin B12 deficiency - and explain in detail?
Ans. is 'b' i.e., Increased methylmalonic acid in urine Isomerization of methylmalonyl CoA to succinyl CoAo In this reaction, the active form of vitamin B12 is deoxyadenosyl cobalamine.o Propionyl-CoA is produced as the catabolic end product of some aliphatic amino acids and b-oxidation of odd chain fatty acids.o Propionyl CoA is then converted to succinyl CoA through methyl malonyl-CoA.o Thus methylmalonyl-CoA is accumulated and excreted in urine as methylmalonic acid (methylmalonate) in vitamin B12 deficiency, i.e. methylmalonic aciduria.