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What is A 34 weeks pregnant female with increased urinary frequency diagnosed of having transient-diabetes insipidus. This patient may have the following associated pathology: and explain in detail?
The development of new-onset diabetes insipidus in the third trimester is usually due to increased vasopressinase activity either due to increased placental production or decreased hepatic vasopressinase metabolism due to liver damage from various causes including preeclampsia, acute fatty liver of pregnancy, or HELLP, syndrome. This phenomenon is called transient vasopressin-resistant diabetes insipidus (DI) of pregnancy. Ref: Mehta N.D., Chen K.K., Monzon C., Rosene-Montella K. (2012). Chapter 223. Common Medical Problems in Pregnancy. In G.V. Lawry, J. Matloff, D.D. Dressler, D.J. Brotman, J.S. Ginsberg (Eds), Principles and Practice of Hospital Medicine.