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What is In post-hepatic jaundice, the concentation of conjugated bilirubin in the blood is higher than that of unconjugated bilirubin because - and explain in detail?
Ans. is 'c' i.e., The conjugation process of bilirubin in liver remains operative without any interferenceJaundiceo Jaundice is not a disease but rather a sign that can occur in many different diseases.o Jaundice is the yellowish staining of skin and sclerae which is caused by high level of blood bilirubin. o On the basis of etiology, jaundice can be divided into 3 types : ?1. Prehepatic jaundiceo Prehepatic jaundice is due to increased production of bilirubin which results an increased bilirubin load presented to the liver.o The liver is normal and is able to conjugate the bilirubin at a normal rate; However, due to overproduction of bilirubin, conjugation capacity of liver is overwhelmed and unconjugate bilirubin is increased --) Unconjugated hyperbilirubinemia.o Prehepatic jaundice is caused by hemolysis, i.e., hemolytic anemia due to any cause, e.g., hereditary spherocytosis, Thalassemia, SCA, Malaria, Drugs (methyldopa, quinine) etc.Hepatic jaundiceo Here the cause lies within the hepatocytes which have either a defect in the conjugation process or in the excretion of conjugated bilirubin into the bile.o This type of jaundice is caused by all causes of hepatitis (infection, alcohol, drugs, toxin or autoimmune); in congenital hyperbilirubenemias; and in cirrhosis.Post hepatic (extrahepatic) jaundiceo Post hepatic jaundice is due to obstruction of the excretion into the bile, e.g., in stone in CBD, carcinoma pancreas, CBD carcinoma etc.o Conjugation capacity of hepatocytes are normal and they continue their conjugation process without any interference leading to conjugated hyperbilirubinemia.