You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is 11 hydroxylase deficiency leads to and explain in detail?
Seen in Newborns and infants, Virilization and the presence of both hypeension and hypokalemia. 11 -deoxycoisol, 17a-hydroxyprogesterone, urinary 17- ketosteroids, and 17-hydroxycoicosteroids are increased. Blood levels and production rates of coisol are usually within normal limits. Physiologic replacement doses of glucocoicoid, such as hydrocoisone or dexamethasone, restores blood pressure to normal levels, corrects K+ depletion, Addition of estrogen-progestogen combined cyclic therapy may be necessary in the adult patient with 17a- hydroxylase deficiency. Reference: GHAI Essential pediatrics, 8th edition