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What is Which of the following 5HT3 receptor blockers has highest receptor affinity and explain in detail?
Palonosetron 5 HT3 subtypes of receptors are impoant for - Emesis - Gut peristalsis - Bradycardia - Transient hypotension - Apnea - Itch 5 HT3 receptor antagonists are: - Ondensetron - Granisetron - Pahmosetron "Among the 5 HT3 receptor blockers palonosetron is a new i.v. agent that has greatest affinity for 5 HT3 receptor and has a long serum half life".