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What is Most serious side effect with sodium polystyrene sulfonate - and explain in detail?
Ans. is 'a' i.e., Intestinal perforation o Sodium polystyrene sulfonate (SPS) exchanges Na+ for K+ in the gastrointestinal tract and increases the fecal excretion of K+.It causes slow increase in serum K+ concentration.The full effect may take up to 24 hours and usually requires repeated doses every 4-6 hours.Intestinal necrosis is the most serious complication of SPS.