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What is Oochronosis occurs in: (Repeat) and explain in detail?
Ans: A (Alkaptonuria) Ref: Harrison's Principles of Internal Medicine, 18th ed.Explanation:AlkaptonuriaAutosomal RecessiveDue to deficiency of homogentisic acid oxidaseClinical featuresOochronosisArthritisCardiac valve involvementCoronary artery calcification Pigmented heart valves, sclera, joint, skin & renal calculiUrine darkens on standingNitisinone used to reduce urinary excretion of homogentisic acid