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What is A patient of Chronic Renal Failure with GFR <40 ml/min/m2 is now suffering from Pulmonary TB. Which of the following drug does not require a dose reduction ? and explain in detail?
Mnemonic : BILE EXCRETED ANTI-MICROBIAL AGENTS: CEF - CEFoperazone, CEFtriaxone R - Rifampacin E- Erythromycin N - Nafacillin A - Ampicilllin L - Lincosamides (Clindamycin) DISEASE - Doxycycline Rifampicin: Its metabolised by liver and excreted the bile.Therefore its dose need not be reduced in a patient with Chronic Renal Failure. Ethambutol and Streptomycin are mainly excreted through the kidney,so they require a dosage modification in Renal Failure.