You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which is true about Sex hormone-binding globulin (SHBG): and explain in detail?
And. A. Binds testosterone with a higher affinity than estradiolSex hormone-binding globulin binds to both testosterone and estradiol, but it binds with higher affinity to testosterone. The bioactivity of testosterone is reduced by SHBG because testosterone cannot bind to its receptor when bound by SHBG. SHBG increases the circulating half-life of testosterone by slowing the clearance and metabolism of testosterone. SHBG does not alter the secretion of inhibin or androgen-binding protein, area