You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Nuclear and cytoplasmic changes in the apoptotic cells are due to and explain in detail?
Activation and Function of Caspases
• The mitochondrial and death receptor pathway leads to the activation of the initiator caspases, caspase 9 and - 8, respectively. Active forms of these enzymes are produced and this cleave and thereby activate another series of caspases that are called the executioner caspases.
These activated caspases cleave numerous targets culminating in activation of nucleases that degrade DNA and nucleoproteins. Caspases also degrade components of nuclear matrix and cytoskeleton, leading to fragmentation of cells.