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What is Cholinesterase activators are useful for treatment of which poisoning ? and explain in detail?
Ref:KD Tripathi pharmacology 6th edition (page.no: 99,105) Cholinesterase reactivators like Oximes(pralidoxime) are used to restore neuromuscular transmission in case of organophosphate anti-ChE poisoning. Organophosphates are Dyflos (DFP) Echothiophate Parathion, Malathion Diazinon(TIK-20) Tabun, Sarin, Soman. Pralidoxime attaches to anionic site of enzyme which remains unoccupied in presence of OP inhibitors. It's Oxime end react with phosphorus atom attached to the esteratic site. Oxime-Phosphonate so formed diffuses away leaving the reactivated ChE.