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What is An elderly male patient presented with blurring of vision. Fundus examination revealed cotton wool spots on retina and systemic examination showed decreased peripheral sensations and increased urine output. What finding is the following renal biopsy showing? and explain in detail?
- Given histopathological slide is showing Kimmelstein Wilson/ Nodular Glomerulosclerosis which is pathognomic of diabetic nephropathy. - OTHER FEATURES OF DIABETIC NEPHROPATHY: - Glomerular lesions like Capillary basement membrane thickening - earliest & most common change in DN Diffuse mesangial sclerosis - presents as nephrotic syndrome in severe cases - Renal vascular lesions, principally aeriolosclerosis - Pyelonephritis, including necrotizing papillitis. - Diabetic microangiopathy which causes thickening of small blood vessels & leaky underlies development of diabetic nephropathy, retinopathy & some forms of neuropathy.