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What is Diazoxide acts by - and explain in detail?
Ans. is 'b' i.e., Inhibiting insulin release Diazoxide inhibits insulin release from P-cells and causes hyperglycemia. o Its action on ATP sensitive IC channel is opposite to that of sulfonylureas --> opening (activation) of IC channels --> Hyperpolarization --> inhibition of insulin release. o Other actions which contribute to hyperglycemia a) peripheral utilization of glucose b) Release of catecholamines It is used in insulinoma.