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What is Most characteristic finding of diabetic nephropathy? and explain in detail?
Diabetic Nephropathy Three lesions are encountered: (1) glomerular lesions; (2) renal vascular lesions, principally aeriolosclerosis; and (3) pyelonephritis, including necrotizing papillitis. The most impoant glomerular lesions are capillary basement membrane thickening, diffuse mesangial sclerosis, and Nodular glomerulosclerosis. Capillary Basement Membrane Thickening. Widespread thickening of the glomerular capillary basement membrane (GBM) occurs in viually all cases of diabetic nephropathy and is pa and parcel of the diabetic microangiopathy Diffuse Mesangial Sclerosis. This lesion consists of diffuse increase in mesangial matrix. Nodular Glomerulosclerosis. This is also known as intercapillary glomerulosclerosis or Kimmelstiel-Wilson disease. It is the Most characteristic finding of Diabetic Nephropathy.