You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is not a myeloproliferative disease - and explain in detail?
The common pathogenic features of myeloproliferative disorders is the presence of mutated, constitutively activated tyrosine kinases or other acquired aberrations in signalling pathways that lead to growth factor independence. It includes CML,POLYCYTHEMIA VERA,ESSENTIAL THROMBOCYTOSIS,primary myelofibrosis. AML is a tumour of haematopoetic progenitors caused by acquired oncogenic mutation that impede differentiation leading to accumulation of immature myeloid blasts in the marrow. Reference :Robbins and Cotran Pathologic basis of disease.South Asia Edition-9 volume 1.page no. 610,616-620