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What is True about methicillin-resistance Staphylococcus aureus (MRSA) is and explain in detail?
Penicillin resistance may also be due to alterations in penicillin-binding protein PBP2a and changes in bacterial surface receptors, reducing the binding affinity 0f beta-lactam antibiotics to cells. This mechanism impas resistance to all beta-lactam antibiotics and has been named methicillin-resistant S.aureus{MRSA}as it was found to be resistant to penicillinase-resistant penicillins like methicillin and cloxacillin. The majority of these strains also show resistance to other antibiotics like erythromycin, tetracyclines, aminoglycosides and cause outbreaks of hospital infection. Ref: Textbook of Microbiology; Ananthanarayanan and Panicker; Tenth Edition pg no 202