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What is All acts through GABAA receptors except - and explain in detail?
Ans. is 'd' i.e., Promethazine GABA RECEPTORS o There are two types of GABA receptors:? 1) GABAA receptors :- These are intrinsic CI channels and when open cause increase in CI conductance and CNS depression. Drugs acting on these receptors are - i) Agnoists :- barbiturates, benzodiazepines, zopiclone, zolpidem, zoleplon, muscimol ii) Inverse agonist:- 0-carboline iii) Antagonist :- Flumazenil. iv) Other drugs :- Alphaxalone, alcohol, anticonvulsants (Gabapentine, vigabaterine), Picrotoxin 2) GABAB receptors :- These are G-protein coupled receptors. Baclofen is agonist and saclofen is antagonist on these receptors.