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What is Kimmelstiel-Wilson lesions are characteristically seen in- and explain in detail?
Diabetic nephropathy - Within 1-2 yrs after onset of clinical diabetes , morphologic changes appear in the kidney. Thickening of GBM is a sensitive indicator for the presence of diabetes . mesangial sclerosis ( accumulation of extracellular matrix in mesangium) is seen . Some patients also develop eosinophilic ,PAS +nodules called kimmelsteil -Wilson nodules . prominent vascular changes are frequently seen with Hyaline and hypeensive aeriosclerosis . Ref:Harrison 20 th edition pg no 2144