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What is Spironolactone is contraindicated with which of the following drugs? and explain in detail?
Ans. (A) Enalapril(Ref: KDT 8/e p635)*Spironolactone is a K+ sparing diuretic. It should be used cautiously if the patient is receiving K+ salts or drugs increasing serum K+ levels.*ACE inhibitors can also cause hyperkalemia as an adverse effect. If these are combined with K+ sparing diuretics, cardiac arrhythmia due to high serum K+ levels may develop.