You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The mechanism of action of uncouplers of oxidative phosphorylation involves: and explain in detail?
Uncouplers are protein carriers that can freely pass through the inner mitochondrial membrane. It allows translocation of the protons into the intermembranous space during the electron transpo in the respiratory chain but blocks the formation of proton gradient across the inner mitochondrial membrane. Thermogenin a protein present in the inner mitochondrial membrane of adipocytes is an example of physiologic uncouplers of oxidative phosphorylation. Examples of uncouplers are: 2,4 dinitrophenol, pentachlorophenol, nigericin, thyroxin and thermogenin. REF: Lippincott book of biochemistry 6th ed.