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What is In drug metabolism, hepatic cytochrome P-450 system is responsible for: and explain in detail?
Ans. (A) Phase I reactions (hydrolysis, oxidation, reduction etc. only(Ref: Katzung 13th/e p60; KDT 8th/e p32)Cytochrome P450 enzymes are responsible for phase I reactions only whereas microsomal enzymes can be involved in phase II also (glucuronide conjugation)