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What is Which of the following is a carbonic anhydrase inhibitor? and explain in detail?
Carbonic anhydrase is an enzyme which catalyses the reversible reaction H2O + CO2 - H2C03 Hence, Carbonic anhydrase functions in CO2 and HC03 transpo and in H+ ion secretion. Carbonic anhydrase inhibitors act by non-competitive but reversible inhibition of this enzyme. eg- tazolamide, dorzolamide and brinzolamide. Hydrochlorothiazide-Inhibits Na-Cl- sympoer acts on distal tubule Furosemide-loop diuretic acting on NA+-K+-2CL PUMP Mannitol-OSMOTIC diuretic