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What is All of the following statements regarding bioavailability of a drug are true, EXCEPT: and explain in detail?
The term bioavailability is used to indicate the propoion of unchanged drug that passes into the systematic circulation after oral administration, taking into account both absorption & local metabolic degradation. The systemic bioavailability of a drug can be predicted from the extent of absorption (function of concentration in plasma) and extraction ratio. So, low bioavailability does not neccessarily mean poor absorption. Ref: Essentials of Medical Pharmacology, 5th Edition, Page 15.