You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is In minimal change disease following is not seen - and explain in detail?
(B) (Normal electron microscopic appearance) (650- Harshmohan 7th)Minimal change disease (910-Rabbins pathologic of Basis of disease)Most frequent clinical presentationNephritic syndrome ** (selectiveproteinuria)PathogenesisUnknown; loss of glomerular polyanion podocyte injuryLight microscopyNormal; lipid in tubulesFluoroscence microscopyNegativeElectron microscopyLoss of foot processes, no depositsMINIMAL CHANGE DISEASE (MED)*Relatively benign disorder is characterized by uniform and diffuse effacement offoot processes of visceral epithelialcell (podocyte), detectable only by electron microscopy in glomeruli that appear virtually normal by light microscopy.*Most frequent cause of nephritic syndrome in children (between 2 and 6 years). The disease sometimes follows a respiratory infection or routine prophylactic immunization.*A characteristic feature its usually dramatic response to corticosteroid therapy.*MCD in adults can be associated with Hodgkin lymphoma and less frequently other lymphomas and leukemias.*In addition secondary MCD may follow NSAID therapy, usually in associated with acute interstitial nephritis.*Hyper coagulation in Nephrotic syndrome is causes by loss of antithrombin III ***Most common fixative used in electron microscopy -formalin**Fixative used in histopathology - 10% buffered neutral formalin