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What is A 40 year old patient presented with heart burn and increased salivation. UGE scopy was done and biopsy was taken and is as shown below. Which of the is the diagnosis? and explain in detail?
Ans. (a) Barret esophagus(Ref: R9/ p 757)Barrett's esophagus is the metaplastic change in the esophageal lining in which the normal squamous epithelium is changed to columnar epithelium due to prolonged gastroesophageal reflux (GERD)Columnar metaplasia, glandular metaplasia, goblet cell metaplsia.Definite diagnosis is made only when columnar mucosa contains the intestinal goblet cells, which will be positive for PAS, Alcian blue (mucin stain)