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What is The drug of choice for the treatment of Pneumocystis jirovei (Pneumocystis carini) pneumonia is and explain in detail?
Pneumocystis jirovecii pneumonia is characterised by progressive dyspnoea with dry cough and fever.Chest X ray shows bilateral interstitial infiltrate spreading out from hilar regions.High resolution CT scan is more sensitive,showing 'ground-glass' interstitial infiltrates.Diagnosis is made with silver stains,PCR,immunofluorescence of bronchoalveolar lavage(BAL)/induced sputum.Treatment is with high dose co-trimoxazole;together with adjunctive steroids if the patient is hypoxic. Reference: Davidson edition23rd pg 584