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What is When nitrates are combined with Calcium channel blockers and explain in detail?
Really Kk sharma 1e p276 Recommendations for combination therapy decisively depend on the choice of the first-line drug. Only nitrates reduce myocardial preload by venodilation and substitute for EDRF-deficiency. ... Therefore, the combination of nitrates with hea-rate-increasing calcium channel blockers, such as nifedipine, should be avoided.