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What is Which of the following can recognize dead material? and explain in detail?
Ans. B. InflammasomeNOD-like receptors (NLRs) and the inflammasomeLocationCytosolic receptorsRecognizeNecrotic cells, ion disturbances (e.g., loss of k), urate crystal, and some microbial productsMechanism of actionActivates Caspase-1- activates IL-1- recruits leukocytes and induces feverRole in diseases* Periodic fever syndromes (autoinflammatory syndromes): Due to gain of function mutations* Obesity associated type 2 diabetes and atherosclerosis: Due to gain of function mutations* Inflammation in gout: Due to recognition of urate crystals by a class of NLRs