You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Which of the following is true regarding Renal Cell Carcinoma? and explain in detail?
Renal Cell Carcinoma arises from the PCT and is usually polar in location. The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. It is more common in males. The classic triad of flank pain, hematuria, and flank mass. The most common presentations include hematuria (40%). Other signs and symptoms include weight loss (33%), fever (20%), hypeension (20%), hypercalcemia (5%), night sweats, malaise, and a varicocele, usually left sided, due to obstruction of the testicular vein (2% of males).