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What is Following is called "gatekeeper of colonic neoplasia" and explain in detail?
Adenomatous polyposis coli (APC) gene Chr 5q21 Gate-keeper of colonic neoplasia Component of WNT signalling pathway Controls cell fate, polarity and adhesion during embryonic devt Controls oncogenic effect of b catenin Germline LOF mutation - Familial Adenomatous Polyposis Colon Cancer (AD) Other tumours - hepatoblastoma, HCC