You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is What is the drug that can be used for rheumatic fever prophylaxis in a patient with a history of allergy to Penicillin? and explain in detail?
The best antibiotic for secondary prophylaxis is benzathine penicillin G (1.2 million units,or600,000units if <=27kg) delivered every 4weeks. It can be given every 3weeks, or even every 2weeks, to persons at, paicularly high risk. Oral penicillin V (250mg) can be given twice daily instead but is less effective than benzathine penicillin G. Penicillin allergic patients can receive erythromycin (250mg) twice daily.Reference: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 381; Acute Rheumatic Fever