You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is ATT drug causing hypothyroidism: and explain in detail?
Ans. (c) PASRef: 2008 WHO guidelines for programmatic management or drug resistant tuberculosisSecond line ATT like PAS (para amino salicylic acid) and ethionamide can lead to hypothyroidism. Exact mechanism is poorly understood.PAS also causes adverse reactions like GI upset, hepatotoxicity, Hypersensitivity.