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What is Aldosterone receptors are present in all except: and explain in detail?
A i.e. LiverAldosterone (or mineralocoicoid) receptor (MR, MLR, MCR) is expressed in central nervous system (hippocampus), hea, kidney, colon, brown adipose tissue and sweat glands but not not in liverQ.It is a steroid hormone receptor that belongs to nuclear receptor subfamily 3, group C, member 2 (NR3C2). It is activated by mineralocoicoids eg. aldosterone & deoxycoicosterone, as well as by glucocoicoids (such as coisol & coisone) and some progestins.Its activation in epithelial cells leads to expression of proteins regulating ionic and water transpo (mainly epithelial sodium channels. ENaC, Na+ - K+ pump, serum & glucocoicoid induced kinase or SGK1) resulting in absorption of Na+ causing increased ECF volume & BP, and an excretion of K+ to maintain a normal salt concentration in body.