You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Roth's spots are seen in - and explain in detail?
Ans. is 'a' i.e., Infective Endocarditis o Roth s spots (lesion) are oval retinal haemorrhages with a clear pale center that are typically seen in patients with subacute bacterial endocarditis. They are believed to be caused by immune complex deposition and are included as a minor criteria amongst Duke s criteria for clinical diagnosis of infective Endocarditis.Major clinical manifestation of infective endocarditis Intravascular lesionsImmunological ReactionsSvstemic Manifestations(occurs due to transmission of microemboli to various organs)(Bacterial infection cause immune complex formation)o Fevero Chillso Rigorso Night sweatso Anorexiao Fatigueo Weakness.o Petechiae (skin, eye, mucosa)o Roth spotso Osier's nodeso Janeway lesionso Splinter hemorrhageso Stroke, myocotic aneurysmo Glomerulonephritiso Arthritiso Finger clubbing