You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is There is mutation of gene coding for the ryanodine receptors in malignant hypehermia. Which of the following statements best explains the increased hea production in malignant hypehermia and explain in detail?
Malignant hypehermia (MH) or malignant hyperpyrexia is a rare life-threatening condition that is usually triggered by exposure to ceain drugs used for general anesthesia -- specifically the volatile anesthetic agents and succinylcholine, a neuromuscular blocking agent. In susceptible individuals, these drugs can induce a drastic and uncontrolled increase in oxidative metabolism in skeletal muscleRef: Ganong&;s review of medical physiology; 24th edition; page no: 320