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What is Which of the following statements about sulfonamides is FALSE? and explain in detail?
(Ref:KDT 6/e p685) Sulfonamides are antimetabolites that act by inhibiting the enzyme folate synthase. Dihydrofolate reductase is inhibited by methotrexate, trimethoprrim and pyrimethamine. These can cause kernicterus in new born if used in late pregnancy. At acidic pH, these can get precipitated and result in crystalluria.