You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is What is the earliest ocular manifestation of pregnancy induced hypeension? and explain in detail?
Fundus changes in Pregnancy Induced Hypeension (Clinical Manifestations in PIH) The clinical course of fundus changes in PIH may be divided into three stages: (i) Spastic stage: Characterised by spasm of retinal aerioles. (ii) The stage of sclerosis: When pregnancy induced hypeensive changes are superimposed on pre-existing organic sclerotic changes in the vessels. (iii) The stage of retinopathy: Characterised by cotton wool spots, micro aneurysms, flame shaped and splinter haemorrhages, hard exudates, disc edema etc. The first change observed in normal retinal aerioles is constriction of the lumen of superior nasal aerioles.