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What is Which of the following drug toxicity can be seen in Crigler Najjar syndrome? and explain in detail?
Ans. C. Atazanavira. In Crigler-Najjar syndrome there is a deficiency/absence of glucuronyl transferase and hence there can be toxicity of drugs metabolized by glucuronidation.b. Drugs metabolized by glucuronidation with established toxicity in case of Crigler-Najjar syndrome are irinotecan and atazanavir