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What is Which of the following agents enhances the bioavailability of levodopa - and explain in detail?
Ans. is 'c' i.e., Entacapone o When peripheral decarboxylation of levodopa is blocked by carbidopa/benserazide, it is mainly metabolized by COMT to 3-0-methyldopa. o Blockade of this pathway by entacaptone/tolcapone fuher prolongs the t 1/2 of levodopa and allows a larger fraction of administered dose to cross to brain.