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What is Which drug abolishes coicomedullary osmotic gradient ? and explain in detail?
Ans. is'a'i.e., Furosemide (Ref. KDT p. 579)Furosemide (Frusemide)It is a high ceiling (loop) diuretic which inhibits of Na+-K+-2cl- cotranspoer.The coicomedullary osmotic gradient is abolished and positive as well as negative free water clearance is blocked.K+ excretion is increased mainly due to high Na+ load reaching DT.