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What is In metabolic acidosis which of the following changes are seen? and explain in detail?
K+ secretion into the renal tubules when the H+ secretion is increased (intracellular Buffering of H+). Thus in metabolic acidosis, there is decreased K+ excretion. Factors afffecting K+ distribution between ECF and ICF concentration Shift Of K+ into the cell - Decrease in ECF K+ Shift Of K+ out of the Cell - Increase in ECF K+ Insulin Insulin deficiency(DM) Aldosterone Aldosterone deficiency (Addison&;s disease) Metabolic alkalosis Hypeonicity (e.g., Hyperglycemia) Diarrhoea Beta Blockers Cell lysis Eg., Intravascular hemolysis, tumor lysis syndrome, rhabdomyolysis Strenous excercise Ref: Guyton and Hall 13th edition Pgno: 387