You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Metoclopramide: and explain in detail?
Ans. (D) Enhances colonic motility(Ref: Katzung 10/e p1021; KDT 8th/e p713)Metoclopramide is a D2 receptor antagonist that increases cholinergic activity by inhibiting presynpatic D2 receptors in GIT (D2 receptor stimulation inhibits the release of ACh).It increase LES tone that is also responsible for anti-emetic action.It does not significantly increase colonic motility.But out of the four options, this is the best answer, because although not significantly but it can increase colonic motility, whereas other options are definitely wrong.