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What is Macrophage activation syndrome is characterized by all except __________ and explain in detail?
Macrophage activation syndrome is characterised by all if the listed feature except Hypoferritenemia . Macrophage activation syndrome(MAS) is rare but potentially fatal complication of systemic JIA. It is characterized by the following: Macrophage hemophagocytosis in the bone marrow Hypofibrinogenemia (paradoxical fall in erythrocyte sedimentation rate ) (ESR) Hyperiglyceridemia Extreme hyperferritinemia Fever > 38.5oC Splenomegaly Cytopenia affecting atleast two or three cell lineages. Reference : nelson textbook of pediatrics 21st edition Pgno: 1262