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What is Antihelminthic which acts by flaccid paralysis of worms is- and explain in detail?
Ans. is 'a' i.e., Piperazine Piperazine o It causes hyperpolarization of ascaris muscle by a GABA agonistic action opening Cl-channels --> flaccid paralysis. o Piperazine safe and well tolerated drug, it is also safe in pregnancy. Remember o Drugs causing flaccid paralysis Ivermectin, piperazine. o Drugs causing spastic paralysis --> Pyrantel pamoate, levamisole.