You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is The complications of Down syndrome include: and explain in detail?
Complications of Down syndrome are: 

Congenital cardiac defects (Most common is ventricular septal defect). 
Increased risk of leukemia particularly ALL (more commonly) and specifically the megakaryoblastic form of AML (M7-AML). 
Hypothyroidism. 
Reduced fertility in females (Males are totally infertile). 
Increased risk of respiratory tract infections.