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What is PRPP (Phospho Ribosyl Pyro Phosphate) is used in : and explain in detail?
Phosphoribosyl Pyrophosphate(PRPP) is used in the synthesis of : 1. Purine 2. Pyrimidine 3. Histidine 4. Niacin synthesis from Tryptophan. NOTE: Phosphoribosyl pyrophosphate (PRPP) paicipates in pyrimidine biosynthesis only subsequent to assembly of the pyrimidine ring. PRPP serves as a scaffold for assembly of the purine ring in purine biosynthesis. The first intermediate formed in the de novo pathway for purine biosynthesisis 5-phosphoribosyl 1-pyrophosphate (PRPP).