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What is Sphingolipids are chiefly accumulated in: and explain in detail?
(CNS): Ref: 11-RS, 110-NMS (307-8 U.S 3rd)SPHINGOLIPIDS: - They comprise another group of lipids found in biological membrane specially in the tissues of nervous system. There are three types of sphingolipids - sphingomyelin, cerebrosides, gangliosides about 6% of membrane lipids of grey matter cells in the brain and gangliosidesSPHINGOLIPIDOSISDiseaseLipid accumulatedPrimary organ affected1. Niemann-Pick diseaseSphingoymelinBrain, Liver, Spleen2. Gaucher's diseaseGlucocerebrosideBrain, Liver, Spleen3. Krabbe's diseaseGalactocerebrosideBrain4. Metachromic leukodystrophyb-Sulfagalactoserebrosidase ceramide trihexosideBrainKidney5. Fabry's disease6. Tay-Sach's diseaseGanglioside GM2Brain