You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Predominant osteoblastic secondaries are seen in - (Repeat) and explain in detail?
Ans: A (Prostate Ca) Ref: Robbins Pathologic Basis of Disease, 8th edition. Bone misc tumors chapter Pg. 1205Explanation:The radiographic manifestations of metastases purely lytic- purely blast it. or mixed lytic and blasticIn lytic lesions, the metastatic cells secrete substances such as prostaglandins, cytokines, and PTH-related protein that stimulate osteoclastic bone resorption; the tumor cells themselves do not directly resorb bone.Lysis of bone tissue rich in growth factors such as TGF-b, IGF-1, FGF. PDGF. and bone morphogenetic proteins, in turn, helps create an environment conducive to tumor cell growth.Prostate adenocarcinoma secretes WNT proteins that stimulate osteoblastic bone formation.Most metastases induce a mixed lytic and blastic reaction.Primaries which produce predominantly lytic bone lesionsCarcinoma of the kidneyCarcinoma of the lungCarcinoma of the gastrointestinal tractMalignant melanomaPrimaries which produce predominantlySclerotic/Osteoblastic lesionsProstate adenocarcinomaCa ColonCa Breast