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What is Diagnostic test for paroxysmal nocturnal hemoglobinuria is: and explain in detail?
(Analysis of GPI-linked proteins) (616-H 16th) (437-CMDT-2009) (661-HI7lh)PAROXYSMAL NOCTURNAL HEMOGLOBINURIA -Diagnosis - Macro-ovalocytes, urine hemosiderin, T LDH, Iron deficiency anemia* TLC and platelet count decreased* Decreased leukocyte alkaline phosphatase* Bone marrow-generated hypoplasia or erythroid hyperplasia* Flow cytometric assays may confirm the diagnoses by demonstrating the absence of CD59 (503-CMDT-07)* Ham test (acidified serum lysis test) and sucrose lysis test (Reduction in ionic strength) are not reliable (616-H)* Analysis of GPI-linked protein (e.g. CD 59, DAF) on RBC and granulocytes by flow cytometry, (616-H)