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What is The most impoant advese effect of sotalol is? and explain in detail?
Ans. is 'a' i.e., Torsades de pointes Sotalol It is a nonselective -blocker. It prolongs the action potential (class 3 antiarrhythmic). Sotalol is well absorbed orally with bioavailibility of 100%. It is not metabolized in liver. Excretion is predominantly by kidney in the unchanged form. The most significant cardiac adverse effect is dose related torsade de points. (Polymorphic ventricualr tachycardia).