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What is Predictable and dose related drug induced hepatic injury is seen with all, EXCEPT: and explain in detail?
There are two major types of chemical hepatotoxicity Direct toxicity-Predictable with sho latent period Idiosyncratic-Not predictable and it can happen at any time Examples of direct hepatotoxic effects Carbon tetrachloride Acetaminophen OCP INH causes idiosyncratic type reaction Hepatitis is infrequent and unpredictable Ref: Harrison, Edition-18, Page-2558