You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Through which of the following does glucose mediated insulin release occur? and explain in detail?
Glucose-mediated insulin release occurs through ATP sensitive K+ channels. Increased blood glucose concentration is the primary controller of insulin secretion. Inside the beta cells, glucose is conveed to glucose-6-phosphate and later ATP is generated. This ATP closes ATP sensitive potassium channels, leading to rise in K+ and depolarisation. This in turn causes opening of voltage gated Ca2+ channels and influx of Ca+. This ultimately leads to secretion of insulin exocytosis. Ref: Guyton and Hall 13th edition Pgno: 990