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What is In primary pulmonary hypeension basic abnormality in genes lies in and explain in detail?
Ref Harrison 19 th ed pg 1655 Abnormalities in multiple molecular pathways and genes that regu- late the pulmonary vascular endothelial and smooth muscle cells have been identified ). These abnormalities include decreased expression of the voltage-regulated potassium channel, mutations in the bone morphogenetic protein receptor-2, increased tissue factor expres- sion, overactivation of the serotonin transpoer, hypoxia-induced activation of hypoxia-inducible factor-1a, and activation of nuclear factor of activated T cells.