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What is Which of the following anesthetic agent may have cerebroprotective affect : and explain in detail?
CBF ICP CMRO2 Thiopentone ||| ||| ||| Ketamine || || | etomidate ||| ||| | propofol ||| ||| ||| ketamine also has antiemetic effect through NMDA receptor. It also has cerebroprotective effect. JOURNAL : Ketamine is said to increase intracranial pressure (ICP), cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) and hence to be unsuitable for neuroanaesthesia. This may require reconsideration in the light of the neuroprotective propeies mediated by the interaction of ketamine with the N-methyl-D-aspaate receptor (NMDA).