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What is POEMS Syndrome includes all, EXCEPT: and explain in detail?
The features of this syndrome are polyneuropathy, organomegaly, endocrinopathy, multiple myeloma, and skin changes (POEMS). Patients usually have a severe, progressive sensorimotor polyneuropathy associated with sclerotic bone lesions from myeloma. Polyneuropathy occurs in ~1.4% of myelomas, but the POEMS syndrome is only a rare subset of that group. Unlike typical myeloma, hepatomegaly and lymphadenopathy occur in about two-thirds of patients, and splenomegaly is seen in one-third. Ref: Harrison's principle of internal medicine 17th edition, Chapter 106.