You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Prolonged administration of streptomycin may result in damage to the: and explain in detail?
Streptomycin (antitubercular) causes vestibular damage on prolonged use.
Adverse effects

This class of drugs is notorious for their adverse effects like ototoxicity and nephrotoxicity.
About 1/5th patients given streptomycin 1 gm BD i.m. experience vestibular disturbances although auditory disturbances are less common. 
Streptomycin has the lowest nephrotoxicity among aminoglycosides; probably because it is not concentrated in the renal cortex.

Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 94,798