You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Syndrome associated with increased risk of leukemia is: and explain in detail?
Genetic disease association of Lympho-haematopoietic malignancies:
Acute leukaemia occurs with increased frequency with a variety of congenital disorders such as:

Down’s syndrome
Bloom’s syndrome
Klinefelter’s syndrome
Wiskott-Aldrich’s syndrome

Mohan H. Textbook of pathology. Jaypee Brothers Medical Publishers; 2015. Edition 7. Page 334