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What is Renal papillary necrosis seen in all except - and explain in detail?
Diabetes mellitus, sickle cell anemia, and anesthetic nephropathy have renal papillary necrosis. Two pathophysiologic mechanisms have been proposed for the development of hypeensive nephrosclerosis. One mechanism suggests that glomerular ischemia causes hypeensive nephrosclerosis. This occurs as a consequence of chronic hypeension resulting in narrowing of preglomerular aeries and aerioles, with a consequent reduction in glomerular blood flow. Alternatively, glomerulosclerosis occurs because of glomerular hypeension and glomerular hyperfiltration. According to this theory, hypeension causes some glomeruli to become sclerotic. As an attempt to compensate for the loss of renal function, the remaining nephrons undergo vasodilation of the preglomerular aerioles and experience an increase in renal blood flow and glomerular filtration. Ref: emedicine.medscape.com