You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A condition which does not have granuloma? and explain in detail?
The dominant histological characteristic of infarction is ischaemic coagulative necrosis, except in the central nervous system where the feature is that of liquefactive necrosis.
It will not lead to granuloma formation.
Granuloma: Focus on chronic inflammation consisting of a microscopic aggregation of macrophages transformed into epithelium-like cells surrounded by a collar of mononuclear leucocytes, principally lymphocytes & occasionally plasma cells.
Types:
Foreign body granuloma, eg. talc, suture Immature granuloma: insoluble particles especially microbes, eg. tubercle granuloma.
Granulomatous inflammation:
TB, leprosy, sarcoidosis, cat scratch disease, brucellosis, syphilis, LGV, berylliosis, some mycotic infections.
Chemical mediators of DHS (delayed hypersensitivity) are:-
IL2, IL3, TNF á, â, IFN by TH1 helper cells
(The chief mediator is IFN Remember: The most important inflammatory mediator = TNF á TH2 helper cells secrete IL 3, 4, 5, 6, 10, 13