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What is Most common receptor for typical antipsychotics is ? and explain in detail?
Ans. is 'b' i.e., D2 ANTIPSYCHOTICS Antipsychotic (neuroleptic) drugs can be divided into typical and atypical. Typical Block D2 receptors Have significant extrapyramidal symptoms (except for thioridazine) - Parkinsonism, Acute muscular dystonia, Akathisia, Malignant neuroleptic syndrome, Tardive dyskinesia. Atypical These are newer generation (second generation) antipsychotics that have weak D2 blocking but potent 5-HT2 antagonistic activity. Called atypical because they have no D2 blocking propey (except resperidone). Extrapyramidal side effects are minimal (Resperidone can cause some extrapyramidal effects). Have no antiemetic effect. Examples are - Clozapine, Risperidone, Olanzapine, Quetiapine, Aripiprazole, Ziprasidone.