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What is All of the following are pyrogenic cytokines, except rpt Q28 and explain in detail?
Refer Robbins 9/e p75-76 inflammation and tissue repair IL-18 is a cytokine that belongs to the IL-1superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18 in presence of IL-12, natural killer (NK) cells and ceain T cells release another impoant cytokine called interferon-g (IFN-g) or type II interferon that plays an impoant role in activating the macrophages or other cells.