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What is Earliest histological change in MI- and explain in detail?
The microscopic appearance also undergoes a characteristic sequence of changes Typical features of coagulative necrosis become detectable within 4 to 12 hours of infarction. "Wavy fibers" also can be present at the edges of an infarct; these reflect the stretching and buckling of noncontractile dead fibers. Sublethal ischemia can also induce intracellular myocyte vacuolization; such myocytes are ble but frequently are poorly contractile. (Robbins Basic Pathology,9th edition,pg no.383)