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What is Most commonly affected organ in the disorder characterized by the peripheral blood smear is: and explain in detail?
Hereditary Spherocytosis—Peripheral blood smear.  
Splenomegaly is more common and prominent in hereditary spherocytosis than in any other form of hemolytic anemia. The splenic weight usually is between 500 and 1000 g. The enlargement results from marked congestion of the splenic cords and increases in the numbers of macrophages. Phagocytosed red cells are seen within macrophages lining the sinusoids and, in particular, within the cords.
Robin’s Textbook of pathology 10th ed Page 442