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What is The transpoer gene defective in Hanup's disease: and explain in detail?
Hanup's disease is due to defective neutral amino acid transpoer. The SLC6A19 is neutral amino acid transpoer involved in the transpo of neutral amino acids like tyrptophan. Tryptophan is the precursor of Niacin (vitamin B3) Hanup'sdisease is associated with pellagra. Extra edge:- Soluble carrier family (SLC) proteins are transmembrane proteins involved in facilitated diffusion and secondary active transpo. Nomenclature of SLC protein is: SLCnXm SLC stands for SoLuteCarrier n = an integer representing a family (e.g., 1-52) X = a single letter (A, B, C, ...) denoting a subfamily m = an integer representing an individual family member (isoform).