You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Botulism is a disease of: - and explain in detail?
Neuromuscular transmission caused by the toxin of the bacterium Clostridium botulinum leads to botulism. C. botulinum produces powerful neurotoxin 'botulinum toxin'(BT). Botulinum toxin is absorbed from the gut, enters the blood circulation, and binds to receptors of presynaptic membranes of motor neurons of PNS and cranial nerves. The toxin does not cross the blood brain barrier or affect the central nervous system. Botulinum toxins act by blocking the release of acetylcholine at synapses and neuromuscular junction- resulting in lack of muscle contraction and flaccid paralysis. C/F - Flaccid ,symmetrical cranial nerve palsy -blurred vision, loss of pupilary reflexes. Symmetrical flaccid descending motor paralysis - Quadriparesis.