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What is Best diagnostic test in Thalassemia is and explain in detail?
(HbF) (310-11- Ghai 6th) (2035- Nelson 18th) (308-Ghai 7lh)Laboratory Investigations in Thalassemia* The infant is bom only with HbF or some cases HbF and HbE (heterozygosity for J3deg thalassemia)* Hb | (2-6 gm/dL), HbF T and HbA2 is nrmal* Reculocyte count is commonly <8% and is in appropriately low compared with the degree of anemia because of ineffective erythropoiesis* Unconjugated serum bilirubin level is usually elevated but the chemistry values may be normal at an early stages* Peripheral smears shows - hypochromia, anisocytosis and poikilocytosis, (Target and tear drop cell, Howell Jolly bodies & Heinz bodies) with marked basophilic stippling* Bone marrow - hypercellular with erythroid hyperplasia with erythroid hyperplasia with increased number of stippled erythroblasts and side roblasts* Osmotic fragility decreased* Serum iron, serum ferritin levels increased