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What is Methicillin resistant staphylococci do not respond to b-lactam antibiotics because: and explain in detail?
(Ref: KDT 6/e p700) Resistance to most penicillins is due to elaboration of beta-lactamase. Methicillin is most resistant penicilling to b-lactamase. Staphylococcus aureus develops resistance to methicillins by acquisition of altered pencillin binding proteins.