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What is Most common organs involved in Wegener's granulomatosis are: and explain in detail?
* Wegener granulomatosis also known as Granulomatosis with polyangiitis * The most common organs involved in Wegener's are lungs and kidneys. * PR3-ANCAs are also present in maximum cases. * PR3 ANCAs are useful markers of disease activity * Histological features : -Upper respiratory tract : lesions shows granulomas with central necrosis and accompanying vasculitis. -Kidney : Focal necrotizing and often crescentic glomerulonephritis.