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What is Anti-tubercular drug not given in liver disease is ? and explain in detail?
Ans. is 'c' i.e., Pyrizinamide o Among the given options, only ethambutol is safe in liver disease. Other three drugs cause hepatotoxicity and should be avoided. o However, if the question is repeated as such, best answer is pyrazinamide because of following statement of Harrison-"In case of presence of hepatic risk factors or if during treatment hepatitis develops in a patient, one might rechallange the patient with rifampicin and isoniazid but pyrizinamide is never given".