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What is A chronic alcoholic have low energy production because of Thiamine deficiency as it is: and explain in detail?
Ans. A. Acting as cofactor for alpha ketoglutarate Dehydrogenase and pyruvate dehydrogenase(Ref. Harper 31/e page 151-155)Alpha ketoglutarate dehydrogenase (TCA cycle) and PDH (link between aerobic glycolysis and TCA) require Thiamine, hence affect energy production, in alcoholic patients thiamin deficiency is present.