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What is Which of the following serological status is seen only in acute hepatitis B infection? and explain in detail?
Ans. a (HBsAg Positive + HBeAg Positive + HBc IgM Positive). (Ref. Harrison medicine 16th ed., 1822, 1831)SEROLOGY OF HEPATITIS B INFECTIONDETECTABLE ANTIGENSDETECTABLE ANTIBODIESA. Hepatitis B Surface Antigen: HBsAg1. First detectable agent in acute Hepatitis B Infection2. Present as early as incubation periodB. Hepatitis B Envelope Antigen: HBeAg1. Highly Infectious State2. Chronic InfectionA. Hepatitis B Surface Antibody: Anti HBsAb IgG1. Prior Hepatitis B Infection with Immunity2. Prior Hepatitis B Vaccine with ImmunityB. Hepatitis B Core Antibody: Anti HBcAb IgM and IgG1. Covers Convalescent perioda. Window between HBsAg clearance to Anti HBsAb conversionb. HBsAg negative during this timeC. Hepatitis B Envelope Antibody: Anti HBeAb IgM and IgG1. Low Infectivity2. Predicts Hepatitis B Resolution DIAGNOSTIC TESTING FOR HEPATITIS B DISEASE 1. HBsAgacutely or chronically infected persons2. Anti-HBspersons who have resolved infections with Hepatitis B; immunity after immunization (Protective antibody)3. HbeAginfected persons at increased risk for transmitting Hepatitis B4. Anti- HBeinfected persons with lower risk for transmitting Hepatitis B5. Anti- HBcacute, resolved, or chronic HBV infection- this is NOT PRESENT after immunization6. IgM anti- HBcacute or recent Hepatitis B infection (including those in HBsAg- negative persons during the "window" phase of infection)