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What is Glycosaminoglycans located in CNS is and explain in detail?
Proteoglycans linked to chondroitin sulfate by the Xyl-Ser O-glycosidic bond are prominent components of cailage. They are located at sites of calcification in endochondral bone and are a major component of cailage. They are found in high amounts in the ECM of the central nervous system and, in addition to their structural function, are thought to act as signaling molecules in the prevention of the repair of nerve endings after injury.Ref: Harper&;s Biochemistry; 30th edition; Chapter 50; The Extracellular Matrix