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What is Goodpasture's syndrome is characterised by : and explain in detail?
Necrotising haemorrhagic interstitial pneumonitis Goodpasture's syndrome is an uncommon autoimmune disease. It shows presence of circulating autoantibiodies against non collagenous domain at a-3 chain of collagen IV. These antibodies initiate inflammatory distruction at basement membrane in glomeruli & lung alveoli, giving rise to RPGN & necrotising haemorrhagic interstitial pneumonitis.