You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Phase I blocker is: and explain in detail?
Phase I blockade is normal action of succinyl choline as depolarization neuromuscular blocker . Phase 2 blockade is is abnormal action of succinylcholine when given in repeated dose and is called desensitisation block. Due to repeated dose the nicotinic cholinergic receptor becomes desensitized by the effect of succinylcholine and now it cannot depolarize it.