You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Amyloidosis deposition most commonly occurs in and explain in detail?
Amyloid is an abnormal pathological protein resulting from the improper folding of proteins and deposited extracellularly as fibrils and disrupt their normal function.
The most common site of deposition is (in decreasing order of incidence) Kidney, Liver, Spleen, Lymph nodes, Adrenals, Thyroid, GIT, Heart. In systemic Amyloidosis, any organ can show deposition of Amyloid. Among all organs, kidneys are most commonly and most seriously get affected by Amyloidosis