You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is This blood smear was taken from an immunodeficient man with fever, night sweats, and weight loss. What is the diagnosis? and explain in detail?
Answer D. Histoplasma capsulatumThe peripheral-blood smear shows a monocyte with a grossly distorted nucleus and numerous intracellular yeast-like organisms 2 to 4 micrometers in diameter with eccentric chromatin. The organisms were surrounded by an artifactual pseudocapsule caused by cytoplasmic shrinkage. These features are diagnostic of Histoplasma capsulatum. H. capsulatum is acquired by the inhalation of conidia or mycelial fragments.