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What is Diphosphoglycerate in red blood cells does not increase on stimulation to: and explain in detail?
2,3-bisphosphoglycerate (2,3-BPG) (also known as 2,3-diphosphoglycerate) is a small molecule created as a side product of glycolysis from 1,2-BPG. A low PO2 in peripheral tissues promotes the synthesis of 2,3-BPG in erythrocytes from the glycolytic intermediate 1,3-BPG. Physiologic changes that accompany prolonged exposure to high altitude include an increase in the number of erythrocytes and in their concentrations of hemoglobin and of BPG. Elevated BPG lowers the affinity of HbA for O2 (increases P50), which enhances the release of O2 at peripheral tissues. Ref: Kennelly P.J., Rodwell V.W. (2011). Chapter 6. Proteins: Myoglobin & Hemoglobin. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.