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What is Adenoma carcinoma sequence was prototypically observed in which carcinoma and explain in detail?
Adenoma of colon has high malignant potential. Potentiality increases with size. If size of adenoma is >2cm there is 30-50% chance of developing carcinoma. If it is 1-2cm then there is 10% chance of developing carcinoma, and if it is less than 1cm then there is 1-5% chance of carcinoma. Reference : SRB's Manual of Surgery, 6th Edition, page no = 890.