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What is All are true regarding Prostaglandins except: and explain in detail?
Ans-ARef: Harpers illustrated Biochemistry,28th editionExplanation:Synthesis from arachidonate (See figure on the next page)FUNCTIONSProstacyclin (PGI2)Inhibit platelet aggregationVasodilatationPGF:Uterine muscle contractionInduce laborBronchoconstrictorPGE:BronchodilatorCauses inflammationThromboxaneSynthesis: plateletFunction: platelet aggregationAspirin - Inhibits TXA2 - | Platelet aggregationAspirin is used in the treatment of myocardial infarctionLeukotrienesThe site of synthesis: leukocytes, platelets, macrophagesSlow reacting substance (SRS-A)Leukotrienes-C, D, EFunctions: InflammationVasoconstrictionBronchoconstriction