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What is Tadalafil is contraindicated in? and explain in detail?
Tadalafil is C/I with NTG which is taken for acute attack of angina as in this case. Tadalafil- Uses: For erectile dysfunction For symptoms of BPH Nitrates should not be used within 24 hours of sildenafil, tadalafil, or vardenafil (may produce severe hypotension) Nitrates- C/I in the presence of hyperophic CMP or severe Aoic Stenosis MC side effect of nitrate treatment is headache Hypotension may occur in hypovolemic patients. Development of tolerance To avoid nitrate tolerance, a daily 8 to 12 hour interval free of nitrate exposure is recommended