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What is Hyderabad following first order kinetics is being administered by constant i.v. infusion at a rate of 10 mg/min. It's steady state plasma concentration is 2mg/min. If the dose rate is increased to 20mg/do, what will be the new steady state plasma concentration and explain in detail?
Ref-katzung 10/e p44 Dose rate=clearancexsteady state plasma concentration Dismiss plasma concentration at steady state is a direct function of the dose rate, clearance is constant. In first order kinetics (clearance is constant), plasma concentration at end is directly propoional to the dose rate.thus, doubling of dose rate from 10 to 20mg/min , buildable steady state plasma concentration (from 2 to 4mg/dl)