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What is Which antibody is a/w the condition showing following features? and explain in detail?
Systemic Sclerosis (Scleroderma) Characterized by vascular injury and progressive perivascular and interstitial fibrosis of multiple organs. Females>Males with age group is 30 to 50 years. Cutaneous involvement is most common. Etiology and pathogenesis Microvascular injury is a hallmark feature of systemic sclerosis. Two clinical categories are: Diffuse scleroderma: Widespead cutaneous involvement. It has two Auto-antibodies: Anti-topoisomerase I (anti-Scl-70) antibodies are specific. RNA polymerase III antibodies.