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What is Gastrin is a marker of which carcinoma? and explain in detail?
Gastrinoma: (Zollinger Ellison Syndrome): Marked hyper recreation of gastrin usually has its origin in gastrin- producing tumor, which are just as likely to arise in the duodenum and peripancreatic soft tissue as in pancreas (so called gastrinoma triangle) Gastrinoma is a type of pancreatic Neuro endocrine tumor(PNET) GI NET:- Gastrointestinal Neuro endocrine Tumor: PNET Carcinoid tumor Patient with MEN I syndrome have more chance of developing gastrinoma. - Medullary carcinoma of thyroid marker: Calcitonin. If patient have calcitonin negative medullary thyroid cancer most impoant tumor marker is CEA. - GIST- Mesenchymal tumor Origin: Cell of Cajal (Pacemaker of GIT) Vascular:- Bleeding Stomach Most specific tumor marker:- DOG-1CD 117>CD 34 - Due to overactivity of tyrosine kinase enzyme DOC :- Imatinib(Tyrosine kinase Inhibitor)