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What is False about HUS - and explain in detail?
HUS ie hemolytic uremic syndrome is associated with microangiopathic hemolytic anaemia, thrombocytopenia. Consumption of platelets leads to thrombocytopenia. It is distinguished from TTP by absence of neurologic symptoms, prominence of acute renal failure.,and its frequent occurence in children. Typical HUS is strongly associated with infectious gastroenteritis caused by E coli strain O157:H7 which elaborates a shiga like toxin. Microangiopathy produce shear stresses that mechanically injure passing red cells and this traumatic damage leads to the appearance of red cell fragments called schistocytes. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition-9 volume 1.page no. 644,659,660