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What is Which of the following statements is true about isotypic variation? and explain in detail?
Antibody genes also re-organize in a process called class switching that changes the one type of heavy chain Fc fragment to another, creating a different isotype of the antibody that retains the antigen specific variable region. This allows a single antibody to be used by different types of Fc receptors, expressed on different pas of the immune system. Ref: Ananthanarayan & Parker's textbook of microbiology 9th edition pg: 94