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What is The rate-limiting step for norepinephrine synthesis and explain in detail?
In the synthesis of Norepinephrine, Tyrosine is hydroxylated to 3,4dihydroxyphenylalanine by tyrosine hydroxylase. This enzyme catalyses the rate limiting reaction and require tetrahydrobiopterin as coenzyme.Ref: Biochemistry, U. Satyanarayana, Fouh edition, page no: 349