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What is TRUE/FALSE about risk factor of carcinoma breast: 1. Nulliparity 2. Multiparity 3. BRCA1 mutation 4. Family history and explain in detail?
"Multiparity is not a risk factor for CA breast". Magnitude of Known Breast Cancer Risk Factors Relative risk<2 Relative risk 2-4 Relative risk>4 Early menarche One-first degree relative with breast cancer Mutation BRCA 1 or BRCA 2 Late menopause CHEK2 mutation LCIS Nulliparity Age >35 at first bih Atypical hyperplasia Estrogen plus progesterone Proliferative breast disease Radiation exposure 40 H Mammographic breast density Alcohol use Postmenopausal obesity H, hormone replacement therapy; LCIS, lobular carcinoma in situ Risk Factor For Breast Cancer Factor impoant in population Age at menarche Parity Age at first Bih Breast- feeding Exogenous hormone use or exposure Alcohol consumption Factor impoant in individual Patients Gender ( F>>M) Age ( steady increase with age Family history ( mothers, sisters, daughters) History of previous breast cancer ( noninvasive or invasive, ipsilateral or contralateral) Histological risk factor Proliferative breast disease Atypical ductal hyperplasia (ADH) Atypical Lobular hyperplasia (ALH) Lobular carcinoma in situ (LCIS) Ref: Schwaz 9/e page 437 ; sabiston 18/e page 862.