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What is Fibrinogen is present in which of the following granules of platelet? and explain in detail?
Platelets play a critical role in normal hemostasis. Their function depends on several glycoprotein receptors, a contractile cytoskeleton, and two types of cytoplasmic granules. a-Granules have the adhesion molecule P-selectin on their membranes and contain fibrinogen, fibronectin, factors V and VIII, platelet factor 4 (a heparin-binding chemokine), platelet-derived growth factor (PDGF), and transforming growth factor-b (TGF-b). Dense (or d) granules contain ADP and ATP, ionized calcium, histamine, serotonin, and epinephrine. Ref: Robbins 8th edition Chapter 4.