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What is Anti-histone antibodies are diagnostic of? and explain in detail?
Ans is 'a' i.e., Drug induced LE * There is an extremely high frequency of antihistone antibodies drug induced LE.Generic antinuclear antibody-Most sensitive for SLEAnti ds DNA & anti smith (Sm)-Most specific for SLEAnti histone-Drug induced lupusAnti-Ro & Anti-La-Neonatal lupus with congenital heart block and sjogren syndromeAnti DNA Topoisomerase (Anti Scl-70)-Diffuse systemic sclerosis (Diffuse scleroderma)Anti - centromere-Localized systemic sclerosis (Localized scleroderma - CREST syndrome)Anti Jo-1 (Histidyl-t-RNA synthase)-Inflammatory myopathiesAnti U1 RNP-Mixed connective tissue disease