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What is Which of the following drugs is preferred for management of depression associated with insomnia? and explain in detail?
In a depressed patient with significant insomnia, miazapine appears to be the most effective therapy. Miazapine is Atypical antidepressant MOA: Blocks a2 auto-( on NA neurons) and hetero (on 5-HT neurons) receptors enhancing both NA and 5-HT release. SSRIs commonly cause insomnia and avoided in patients with significant insomnia.