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What is Which of the following is not seen in MEN1? and explain in detail?
Features of Multiple Endocrine Neoplasia (11q l3)/Intron 4 ss : Parathyroid adenoma (90%)- Most common presentation. Entero-pancreatic tumours- Most common is gastrinoma and least common is V.I.Poma in MEN1. Pituitary adenoma- most common is Prolactinoma and least common is non-functioning adenoma in MEN1. Associated tumours. Adrenal coical tumour. Neuroendocrine tumours- thymus, lungs (Foregut derivatives include bronchus and thymus and hence choice B is correct). Lipoma Angiofibroma -Most common skin manifestation in MEN 1 (Angiofibroma>collagenoma) Brain tumour -meningioma Pheochromocytoma (<1%)