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What is Crushman spiral is characteristic of which of the following airway disease: and explain in detail?
Ans. (d) Bronchial asthmaRef: Robbiris pathology 9th ed. /682Findings in Bronchial Asthma in Broncho-Alveolar Lavage or in Sputum* Curschmann spirals, is a finding in bronchial asthma which may result from extrusion of mucus plugs from subepithelial mucous gland ducts or bronchioles.* Charcot-Leyden crystals: it is composed of an eosinophilic protein called galectin-10.The other characteristic histologic findings of asthma, collectively called "airway remodeling" include:* Airway wall thickenig* An increase in the size of the submucosal glands and number of airway goblet cells* Subbasement membrane fibrosis (due to deposition of type I and III collagen)* Increased vascularity* Hypertrophy and/or hyperplasia of the bronchial wall muscle