You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is A malignant tumor of childhood, that metastasizes to bones most often, is: and explain in detail?
Neuroblastoma is the most common solid neoplasm outside the CNS. It arises from neural crest tissue of the sympathetic ganglia or adrenal medulla. It most commonly metastasize to bone, bone marrow, lymph nodes, liver and subcutaneous tissue. It has a predilection for metastasis to the skull, paicularly the sphenoid bone and retrobulbar tissue. Ref: Essential Pediatrics By O P Ghai, 6th Edition, Page 573; CURRENT Diagnosis and Treatment: Pediatrics, 20th Edition, Chapter 29.