You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Apoprotein associated with LDL: and explain in detail?
Ans. b (B-100). (Ref. Harper Biochemistry 27th ed. table. 26-1)A-l--Activates LCAT., B-100--Binds to LDL receptor and mediates VLDL secretion., C-II--Cofactor for lipoprotein lipase., B-48--Mediates chylomicron secretion., and E--Mediates Extra (remnant) uptake.ApolipoproteinsApo-AI, A-l 1, A-IVfound in HDL and chylomicronsApo-AI, All, AIVfound primarily on HDLApo-AI and Allsynthesized in liver and intestineApo-A IVsynthesized in intestine only.Apo-AIcomprises 70-80% protein of HDL All: is second most abundant in HDLApo-AILCAT activator and inversely related to CHDB-100mainly with LDLB-48mainly with chylomicron.Composition of the Lipoproteins in Plasma of Humans.LIPOPROTEINSourceMAJOR LIPIDELECTROPHO- RETIC MOBILITYMAJOR APOPRO- TEINSPROTEIN CONTENTApoli- poproteins1. ChylomicronIntestineTriglyceride (no mobility)NoneB-48, A-I, IV--A-I, A-II, A- IV,1 B-48, C-I, C-II, C-III, E2. VLDLLiver (intestine)TriglyceridePre-BetaB-100,E,--B-100, C-I, C-II, C-III3. IDLVLDLTriglyceride and cholesteryl estersBetaB-100, E--B-100, E4. LDLVLDLCholesteryl estersBetaB-100--B-1005. HDLLiver, intestine, VLDL,chylomicronsPhospholipids and CholesterolAlphaA-l, IIHighestA-I, A-II, A-IV, C-I, C-II, C-III, D,2 E