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What is site of deposition of a mitochondira seen in organs of all cells except ? and explain in detail?
DYSTROPHIC CALCIFICATION : Pathogenesis : The final common pathway is the formation of crystalline calcium phosphate Process - two major phases: initiation (or nucleation) and Propagation * Both can occur intracellularly and extracellularly * Initiation of intracellular calcification occurs in the mitochondria * Initiators of extracellular dystrophic calcification include phospholipids found in membrane-bound vesicles - matrix vesicles Sites of Metastatic calcification * May occur in any normal tissue of the body but affects the following organs more commonly: * Kidneys, especially at the basement membrane of tubular epithelium and in the tubular lumina causing nephrocalcinosis * Lungs, especially in the alveolar walls. * Stomach, on the acid-secreting fundal glands. * Blood vessels, especially on the internal elastic lamina. * Cornea: another site affected by metastatic calcification. * Synovium of the joint causing pain and dysfunction. Tubular basement membrane in nephrocalcinosis due to hypercalcaemia REF : robbins 10th ed