You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information.
What is Irreversible injury in myocardium occurs at - and explain in detail?
Ans-Bo Myocardial function is more sensitive to ischemia(loss of contractility occurs within 60 seconds) than myocardial structure (irreversible injury occurs in 20-40 minutes, thus myocardial necrosis begins at approximately 30 minutes after coronary occlusion.FeatureTimeo Onset of ATP depletiono Loss of contractilityo ATP reduced to 50%o ATP reduced to 10%o Irrversible injuryo Microvascular injurySeconds< 2 minutes10 minutes40 minutes20-40 min> 1 hr