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What is Loading dose is given for which of the following drug and explain in detail?
Chloroquine is a drug having maximum Volume of Distribution (Vd >1300 L). This means it is mostly distributed in the tissues whereas the main site of its pharmacological action is RBCs. Therefore, it is given as a loading dose to attain steady state plasma concentration quickly. Chloroquine is a synthetic 4-aminoquinoline that has been the mainstay of antimalarial therapy, is the drug of choice in the treatment of erythrocytic P. falciparum malaria, except in resistant strains.