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What is Pneumocystis carinii is a fungus because ? and explain in detail?
Ans. is 'a' i.e., rRNA, Mitochondrial protein gene sequence & presence thymidylate synthase; `b' i.e., Cell wall contains glucans; 'c' i.e., Antifungals are effective against p. carinii . The taxonomic classification of Pneumocystis as a fungus is based on factors: 1. Analysis of gene sequence for ribosomal RNA, mitochondria! proteins and major enzymes. 2. Presence of b-1, 3 glucan in the cell wall. 3. The efficacy of antifungal drugs that inhibit b-glucan synthesis. . In contrast to most fungi. 1. Pneumocystis lacks ergosterol 2. Not susceptible to antifungal drugs that inhibit ergosterol synthesis.