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What is Genetic expression of Na KATPAse inducible by- and explain in detail?
Ans. is 'a' i.e.. Aldosterone Mineralocorticoid actionso The principal mineralocorticoid secreted by adrenal cortex is aldosterone.o The main action of aldosterone is to enhance Na+ reabsorption in the distal convoluted tubule in kidney.o There is an associated increase in K+ and H+ excretion.Excess mineralocorticoid - Na+ and water retention (Hypertension & edema), Hypokalemia, Alkalosis.Mineralocorticoid deficiency (Addison's disease) - Hyperkalemia. Acidosis, Hypotension,o Mechanism of actionMineralocorticoid acts on cytoplasmic receptors.It increases transcription of m.RNA in renal tubular cells to symthesis Aldosterone - induced protein (ATP) which is Na+ K+ ATPase.Symthesis of b-subunit of amiloride sensitive Na+ channel is also induced.