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0 | Is the alkylation response protein AidB localized at the new poles and constriction sites in Brucella abortus? | Data reported here suggest that AidB is a marker of new poles and constriction sites, that could be considered as sites of preparation of new poles in the sibling cells originating from cell division. The possible role of AidB in the generation or the function of new poles needs further investigation. |
1 | Does intrathecal IgM synthesis predict the onset of new relapses and a worse disease course in MS? | The presence of oligoclonal IgM bands in CSF can be a prognostic marker in the early phases of MS. |
2 | Does short term lead exposure induce a stress-like response in adult mice? | These results support the hypothesis that exposure to lead of the adult mice affects a behavioral and hormonal response consistent with stress. |
3 | Is protection of Malian children from clinical malaria associated with recognition of multiple antigens? | The present study provides immune-epidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria. |
4 | Is miR-16 and miR-21 expression in the placenta associated with fetal growth? | Our study is one of the first to investigate placental miRNA expression profiles associated with birthweight and SGA status. Future research on miRNA whose expression is associated with in utero exposures and markers of fetal growth is essential for better understanding the epigenetic mechanisms underlying the developmental origins of health and disease. |
5 | Does ex vivo gene therapy prevent chronic graft vascular disease in cardiac allografts? | Hyperbaric transfection of antisense oligodeoxynucleotides proved highly efficient, effective at blockade of intracellular adhesion molecule-1, and demonstrated a sequence-specific reduction in chronic graft vascular disease. This highly targeted alteration of donor organ immunogenicity may have an important future role in clinical immunosuppressive strategies. |
6 | Does hepatitis E Virus Contribute to Hepatic Decompensation Among Patients With Advanced Chronic Hepatitis C? | HEV does not appear to be a significant cause of hepatic decompensation among persons with previously stable, advanced chronic hepatitis C in the United States. |
7 | Do genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes? | We identified a class of functions that are associated with either high or low promoter conservation in mammals. We detected a significant tendency that points to complex and adaptive processes were associated with higher promoter conservation, despite the fact that they have emerged relatively recently during evolution. We described and contrasted several hypotheses that provide a deeper insight into how transcriptional complexity might have been emerged during evolution. |
8 | Does the new tubulin-inhibitor combretastatin A-4 enhance thermal damage in the BT4An rat glioma? | CA-4 induces a gradual reduction in tumor blood flow which can be exploited to sensitize the BT4An tumor for hyperthermia. |
9 | Does pre-operative quadriceps strength predict IKDC2000 scores 6 months after anterior cruciate ligament reconstruction? | Pre-operative quadriceps strength can predict IKDC2000 scores 6 months after ACL reconstruction. Deficits in pre-operative quadriceps strength influence self-reported function 6 months after surgery. Factors that are known to influence quadriceps strength and self-reported outcomes do not influence the relationship between pre-operative quadriceps strength and post-operative IKDC2000 scores. |
10 | Do inflammatory breast cancers in Tunisia and France show similar immunophenotypes? | The IBC from Tunisia were not different from those observed in France on the basis of IHC profiles. However, the younger age of the patients suggest a specific epidemiological context that should be investigated. |
11 | Is plecanatide , an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract , safe and well-tolerated in single doses? | Plecanatide, an oral GC-C agonist, acting locally within the GI tract without measurable systemic exposure, was safe and well-tolerated in single doses up to 48.6 mg. The study was not powered for statistical analyses, but trends in PD parameters supported continued clinical development. |
12 | Are differential alterations of the genes in the CDKN2A-CCND1-CDK4-RB1 pathway associated with the development of head and neck squamous cell carcinoma in Indian patients? | Our study suggested that mutation/hypermethylation/allelic alterations (LOH/MA) of CDKN2A were associated with the development of dysplastic head and neck lesions. All the other alterations might provide some cumulative effect during progression of later stages of the tumour to have selective growth advantages. |
13 | Does chronic administration of anabolic androgenic steroid alter murine thyroid function? | Our data indicate that DECA exerts direct actions on the thyroid gland and in the peripheral metabolism of thyroid hormones and might lead to thyroid dysfunction. |
14 | Do intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy? | The present analysis shows that infectious conditions delay liver regeneration. Our data suggest a cross-linkage of both conditions via the functional liver capacity. A direct role of microorganisms seems unlikely; however, the inhibitory effect of the pro-inflammatory cytokines may be involved. |
15 | Does variability of the be revealed ionization enhancement by bile acid in mouse plasma? | The variability of TCA levels in plasma as well as the observed instability of the chromatographic retention complicates the evaluation of TCA-induced matrix effects during method development. Thus, monitoring the IS response in incurred samples is a useful tool to evaluate the performance of a validated method. |
16 | Does ethanol protect from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor? | Experimental ethanol ingestion rapidly increases VEGF production, significantly increasing the capillary bed in the heart, brain, and skeletal muscle. Moreover, the ethanol-induced increase of blood vessel density is protective against ischemic events (i.e., hindlimb ischemia and myocardium ischemia/reperfusion) and promotes skeletal muscle regeneration. |
17 | Is statin intake associated with decreased insulin sensitivity during cardiac surgery? | Preoperative use of lipophilic statins is associated with increased insulin resistance during cardiac surgery in nondiabetic, dyslipidemic patients. |
18 | Does ginkgo biloba leaf extract enhance levels of caspase-3 and amyloid precursor protein in normal rat hippocampus? | GbE can raise the levels of caspase-3 and APP in the hippocampus of normal rats. |
19 | Is high leg salvage rate after infrainguinal bypass surgery for ischemic tissue loss ( Fontaine IV ) compromised by the short life expectancy? | Infrainguinal bypass grafting results in a high rate of leg salvage. Amputation-free survival was low during the follow-up due to the high mortality of patients with CLI and tissue loss. Several co-morbidities of the CLI patients were associated with decreased amputation-free survival. |
20 | Does induction of anesthesia alter tricuspid annular velocities : a tissue Doppler assessment? | Induction of anesthesia for CABG surgery does not alter velocity-based parameters of RV function. There was a small decrease in TAPSE. The TD parameters were lower in CABG patients compared with the normal group. |
21 | Is vernier zone residue 4 of mouse subgroup II kappa light chains a critical determinant for antigen recognition? | A structural explanation for the changed binding characteristics can be the influence of the position 4 residue, as being a constituent of the Vernier zone, on the position of the CDR1 loop of Vkappa, which might harbour residues that directly bind to antigen, or indirectly positions other variable loops of the binding pocket. An increased sensitivity for trypsin digestion supported the hypothesis of a local conformational change in the serine mutant of the subgroup II kappa containing antibody. |
22 | Does ferruginol inhibit non-small cell lung cancer growth by inducing caspase-associated apoptosis? | The findings of the present study provided insight into the molecular mechanisms underlying ferruginol-induced apoptosis in non-small cell lung cancer (NSCLC) cells, indicating that this compound may be a potential candidate drug for anti-NSCLC. |
23 | Does p115 promote growth of gastric cancer through interaction with macrophage migration inhibitory factor? | P115 promotes proliferation of gastric cancer cells through an interaction with MIF. |
24 | Does leukamenin F suppress liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production? | Our results demonstrated that Leukamenin F could attenuate CCl(4)-induced liver fibrogenesis in mice as an efficient inhibitor against both HSC proliferation and ECM production. This natural product provides a valuable structural hint for the development of anti-liver fibrosis reagents. |
25 | Does misoprostol treatment for early pregnancy failure impair future fertility? | Misoprostol treatment, for women with first trimester missed abortion and favorable reproductive history, is an acceptable treatment with no detrimental effect on future fertility. |
26 | Does adequate intake of potassium cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system? | This study demonstrates that an increase in dietary potassium over a 4-wk period is safe in hypertensive subjects who have normal renal function and are receiving ACEi and/or ARB therapy. This trial was registered at www.clinicaltrials.gov as NCT02759367. |
27 | Does interferon gamma induce differential upregulation of alpha and beta chemokine secretion in colonic epithelial cell lines? | These studies suggest that intestinal epithelial cells may produce chemokines capable of attracting both neutrophils and monocytes. The ability of IFN-gamma to activate the expression of beta chemokines preferentially could facilitate the development of chronic inflammatory infiltrates. |
28 | Does individual variation in pheromone response correlate with reproductive traits and brain gene expression in worker honey bees? | Our studies demonstrate that there is substantial variation in worker attraction to QMP among individuals, and that this variation is linked with specific differences in physiology and brain gene expression patterns. This variation in individual response thresholds may reveal underlying variation in queen-worker reproductive conflict, and may mediate colony function and productivity by creating variation in individual task performance. |
29 | Do self-report measures of well-being predict incident harm due to self-neglect in cognitively impaired seniors who live alone? | GDS and self-rated health are simple measures to administer in the primary care setting and may be useful to PCPs in the earlier identification of those at greatest risk of harm in this vulnerable group of patients. |
30 | Is the growth hormone receptor exon 3 polymorphism associated with height or metabolic traits in healthy young adults? | The GHRd3 genotype was negatively associated with birth size but it was not associated with adult height or weight, plasma IGF1, metabolic phenotype or any marker of increased cardiovascular risk in young adults. |
31 | Is insulin-induced epidermal growth factor activation in vascular smooth muscle cells ADAM-dependent? | Insulin can induce transactivation of EGFR by an ADAM-mediated, HB-EGF-dependent process. This is the first description of cross-talk via ADAM between insulin and EGFR in VSMC. Targeting a pivotal cross-talk receptor such as EGFR, which can be transactivated by both G-protein-coupled receptors and receptor tyrosine kinases is an attractive molecular target. |
32 | Does incidence of post-endoscopic retrograde-cholangiopancreatography/sphincterotomy pancreatitis depend upon definition criteria? | The incidence of post-procedure pancreatitis ranged from 1.9% to 11.7% depending on the definition criteria adopted. |
33 | Does regional low-flow perfusion provide cerebral circulatory support during neonatal aortic arch reconstruction? | Regional low-flow perfusion is a safe and simple bypass management technique that provides cerebral circulatory support during neonatal aortic arch reconstruction. The reduction of deep hypothermia and circulatory arrest time required may reduce the risk of cognitive and psychomotor deficits. |
34 | Are cocoa procyanidins stable during gastric transit in humans? | The results suggest that most ingested procyanidins reach the small intestine intact and are available for absorption or metabolism. |
35 | Does home monitoring program reduce interstage mortality after the modified Norwood procedure? | In the first 5 years of the HMP, all infants discharged after a modified Norwood procedure survived the interstage period. The HMP altered clinical management in 37% of patients. Home monitoring of oxygen saturation, heart rate, weight, and feedings, along with comprehensive care coordination, allowed timely interventions and reduced interstage mortality from 7% to 0%. |
36 | Do the Influence of an undergraduate scientific initiation programme onn the professional profile of new physicians? | Apparently, taking part in a SIP led to lower income and worse civil servant recruitment exam results. However, this may only reflect a transient phase in a long-term process. New research currently under way will answer this remaining question, now that more time has elapsed since graduation. Rev Port Pneumol 2010; XVI (5): 797-808. |
37 | Is superficial zone cellularity deficient in mice lacking lubricin : a stereoscopic analysis? | Increased Caspase-3 activation is observed in Prg4 deficient mice compared to Prg4 sufficient littermates. Absence of Prg4 induces loss of chondrocytes in the superficial and upper intermediate zone of mouse cartilage that is quantifiable by a novel image processing technique. |
38 | Do collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin alpha2beta1 and glycoprotein VI? | Triple-helical peptides with specific receptor-binding motifs mimic the properties of native collagen I in thrombus formation by binding to both platelet collagen receptors. At a high-shear rate, either GPIb or high-affinity (but not low-affinity) GXX'GER mediates GPVI-dependent formation of procoagulant thrombi. By extension, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens. |
39 | Does long-term CPAP treatment partially improve the link between cardiac vagal influence and delta sleep? | Long-term nasal CPAP restored, in severe SAHS, the information between cardiovascular and sleep brainstem structures by increasing gain, but did not improve its tightness or time shift. |
40 | Is nuclear localization of survivin a positive prognostic factor for survival in advanced non-small-cell lung cancer? | Our results indicate that differential localization of survivin may be a prognostic factor for NSCLC. Further studies are warranted. |
41 | Does material hardship alter the diurnal rhythm of salivary cortisol? | Material hardship among poor women is associated with changes in the diurnal rhythms of cortisol, particularly in the waking response, which is blunted in women with high levels of hardship. |
42 | Does dipeptidyl peptidase-4 inhibitor sitagliptin improve pancreatic β-cell function in hypertensive diabetic patients treated with angiotensin receptor blockers? | Treatment with the DPP-4 inhibitor sitagliptin might exert beneficial effects on pancreatic β-cell function in ARB-treated T2DM patients and its efficacy might be more pronounced in hypoglycemic drug naïve patients. |
43 | Does levels and correlate of exercise in a border mexican american population? | Understanding personal and environmental factors that influence physical activity and exercise in this minority population is critical for the development of culturally sensitive health interventions. |
44 | Is self-reported obstructive sleep apnea associated with nonresponse to antidepressant pharmacotherapy in late-life depression? | OSA may impair response to antidepressant pharmacotherapy in depressed older adults. Future studies of antidepressant response rates among depressed older adults with OSA should both prospectively diagnose OSA and monitor adherence to treatments such as continuous positive airway pressure. |
45 | Does comparison of protein interaction networks reveal species conservation and divergence? | Our result demonstrates that the cross-species comparison strategy we adopt is powerful for the exploration of biological problems from the perspective of networks. |
46 | Does hybrid approach improve success of chronic total occlusion angioplasty? | Hybrid-trained operators can achieve overall success rates of 90% in real world practice with acceptable MACE. Use of dissection re-entry and investment procedures maintains high success rates in complex lesions. The hybrid approach represents a significant advance in CTO treatment. |
47 | Is cerebral Hypoperfusion in Posterior Reversible Encephalopathy Syndrome Different from Transient Ischemic Attack on CT Perfusion? | If confirmed by other groups, CTP and CTA imaging in patients with acute visual loss and confusion may help to distinguish PRES from bi-occipital ischemia. These radiological parameters may identify PRES patients at risk for additional tissue infarction. |
48 | Does genomic Characterization of Renal Cell Carcinoma with Sarcomatoid Dedifferentiation pinpoint Recurrent Genomic Alterations? | Two of three patients with sRCC who underwent genomic profiling of both their epithelial and sarcomatoid components demonstrated identical mutational profiles, and a third case demonstrated commonly disrupted genes. Of the 26 sRCCs, TP53 (42.3%), VHL (34.6%), CDKN2A (26.9%), and NF2 (19.2%) were the most frequently altered genes. NF2 mutations were mutually exclusive with TP53 but not with VHL mutations. Limitations include the small sample size. |
49 | Does [ Over-expression of Hypoxia-inducible factor 1alpha increase invasive potency of LNCaP cells in vitro ]? | Over-expression of HIF-1alpha stimulates the invasion potency of human prostate carcinoma cell. The expression of E-cadherin, vimentin, MMP-2, cathepsin D, and uPAR, all playing an established role in the invasion of tumor, can be regulated by HIF-1 in human prostate cancer cell. |
50 | Does earthing ( grounding ) the human body reduce blood viscosity-a major factor in cardiovascular disease? | Grounding increases the surface charge on RBCs and thereby reduces blood viscosity and clumping. Grounding appears to be one of the simplest and yet most profound interventions for helping reduce cardiovascular risk and cardiovascular events. |
51 | Does mutational analysis of betaCOP ( Sec26p ) identify an appendage domain critical for function? | Together, these results indicate an essential function for the predicted betaCOP appendage and suggest that both COPI appendages perform a biologically active regulatory role with a structure related to adaptin-family appendage domains. |
52 | Do inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase? | Our data define a pathway in which inflammation and mechanical stretch lead to vascular inflammation that promotes collagen deposition. The resultant increase in aortic stiffness likely further worsens systolic hypertension and its attendant end-organ damage. |
53 | Do agroecosystems shape population genetic structure of the greenhouse whitefly in Northern and Southern Europe? | Taken together our results show that greenhouse agroecosystems can limit gene flow among populations in both climate zones. Fragmented populations in greenhouses could allow for efficient pest management. However, pest persistence in both climate zones, coupled with increasing opportunities for naturalization in temperate latitudes due to climate change, highlight challenges for the management of cosmopolitan pests in Northern and Southern Europe. |
54 | Does role of early postradiation magnetic resonance imaging scan in children with diffuse intrinsic pontine glioma? | There is no significant difference in tumor size of DIPG patients who have received standard RT when measured at 2 weeks vs. 6-8 weeks after RT. The majority of patients had the largest change in tumor size at the 2-week post-RT scan, with evolving changes documented on the 6-8-week scan. Six of 11 patients had progressive ventriculomegaly without obstruction, suggestive of communicating hydrocephalus. To the best of our knowledge, this is the first documentation of this phenomenon in this cohort of patients. |
55 | Do complementary and alternative medicines use among pediatric patients with epilepsy in a multiethnic community? | While some caregivers gave CAMs to their PPE, they had various misconceptions and did not discuss the usage with their healthcare providers. We propose that the predictors identified in this study can help to identify potential CAM users. Healthcare providers should routinely probe about the usage of CAMs by PPE, and thereafter, the suitability of CAM use could be evaluated. The caregivers will benefit from open discussion with healthcare professionals on the safe use of AEDs with or without CAMs. |
56 | Does a transient breach in the epithelial barrier lead to regulatory T-cell generation and resistance to experimental colitis? | A mild and/or transient breach in epithelial barrier function leads to dominant regulatory T-cell responses that protect the mucosa from inflammation. |
57 | Do neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase ( SSADH ) deficiency suggest a heightened excitatory state during development? | Our findings indicate early GABAergic alterations in Aldh5a1-/- mice, possibly exacerbated by other metabolites, which likely induce a heightened excitatory state that may predispose neural networks to epilepsy in these animals. |
58 | Does hypertonic saline worsen infarct volume after transient focal ischemia in rats? | These data demonstrate that hypernatremia resulting from postischemic HS infusion worsens cortical infarct volume in transient focal cerebral ischemia. The deleterious effect is not linked to exacerbation of delayed hypoperfusion during early reperfusion (6 hours); however, blood flow defects at later recovery time points remain to be excluded. These results may have implications for HS therapy in clinical ischemic stroke. |
59 | Do the radioprotectors amifostine and sodium selenite modify the radiosensitivity of rat rhabdomyosarcomas? | The application of amifostine and sodium selenite to conventionally fractionated irradiation have no influence on the radiosensitivity of the rhabdomyosarcoma R1H. The systemic toxicity of amifostine might be of importance for the radiation treatment of a patient. |
60 | Is obesity Associated with Increased Short-term Complications After Primary Total Shoulder Arthroplasty? | Although the surgical time increased for patients with greater BMI, the 30-day complications and perioperative hospitalization data after TSA were not different in patients with increased BMI levels. Obesity alone should not be a contraindication for TSA, and obese patients can expect similar incidences of postoperative complications. The preoperative medical optimization plan should be consistent with that of patients who are not obese who undergo TSA. |
61 | Is residual amount of HBV DNA in serum related to relapse in chronic hepatitis B patients after cessation of nucleos ( t ) ide analogs? | Residual amount of HBV DNA in serum at NA cessation is associated with HBV relapse. The cutoff value predicting relapse was 2.24 IU/mL, with a sensitivity of 0.553 and specificity of 0.840. |
62 | Is magnetic resonance angiography equivalent to X-ray coronary angiography for the evaluation of coronary arteries in Kawasaki disease? | In conclusion, MRA is a reliable diagnostic tool, equivalent to XCA for coronary artery aneurysm identification in patients with KD. Magnetic resonance angiography may prove to be of great value for the serial non-invasive evaluation of these patients. |
63 | Does hepatic Notch2 deficiency lead to bile duct agenesis perinatally and secondary bile duct formation after weaning? | Cholangiocyte differentiation becomes progressively less dependent on NOTCH2 signaling with age, suggesting that ductal-plate formation is dependent on NOTCH2, but subsequent cholangiocyte differentiation is not. |
64 | Are aPC and KRAS mutations in distal colorectal polyps related to smoking habits in men : results of a cross-sectional study? | Cigarette smoking is associated with a higher risk of developing both HP and AP and a higher prevalence of mutations in APC and KRAS. |
65 | Are interbody device shape and size important to strengthen the vertebra-implant interface? | The cloverleaf-shaped indentor displayed an improved strength and stiffness profile when compared to oval or kidney-shaped indentors of similar surface areas. |
66 | Do hLA class II gene associations in African American type 1 diabetes reveal a protective HLA-DRB1*03 haplotype? | The unique diversity of the African HLA region we have uncovered supports a specific and major role for HLA-DRB1 in HLA-DRB1*03 haplotype-associated Type 1 diabetes risk. |
67 | Is hSP90 inhibition effective in breast cancer : a phase II trial of tanespimycin ( 17-AAG ) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab? | This is the first phase II study to definitively show RECIST-defined responses for 17-AAG in solid tumors. Tanespimycin plus trastuzumab has significant anticancer activity in patients with HER2-positive, metastatic breast cancer previously progressing on trastuzumab. Further research exploring this therapeutic interaction and the activity of HSP90 inhibitors is clearly warranted. |
68 | Are carotid stents a source of microemboli late after deployment? | Carotid stents seem to have a very low emboligenic potential after the early post-deployment period. This is a reassuring message for present and future patients harboring such stents. |
69 | Are age and body mass index independent risk factors for the development of postoperative paralytic ileus after radical cystectomy? | Our results showed that increasing age and BMI were significantly associated with the presence of POI in patients undergoing radical cystectomy for bladder cancer. |
70 | Does aspirin protect endothelial cells from oxidant damage via the nitric oxide-cGMP pathway? | Our data suggest that endothelial NO synthase is a site of action of aspirin and that the NO/cyclic GMP system assumes a crucial function in mediating the cytoprotective action of aspirin. |
71 | Do management of malignant tracheoesophageal fistulas with a cuffed funnel tube? | For occlusion of malignant respiratory tract fistulas this cuffed flange tube proved to be superior to conventional esophageal prostheses. |
72 | Is reduced bone mineral density associated with breast arterial calcification? | These data suggest that osteoporosis and arterial calcification are strongly and independently correlated. Reduced BMD may identify women at risk of vascular disease. |
73 | Does met-CCL5 represent an immunotherapy strategy to ameliorate rabies virus infection? | These results suggest that CCL5 in the CNS is a key regulator involved in inducing rabies encephalomyelitis. Furthermore, treatment with the CCL5 antagonist Met-CCL5 prolongs survival time of the mice infected with attenuated or street RABVs, which might represent a novel therapeutic strategy to ameliorate RABV infection. |
74 | Does prophylactic amnioinfusion improve outcome of pregnancy complicated by thick meconium and oligohydramnios? | Amnioinfusion improves the outcome in pregnancies complicated by thick meconium and oligohydramnios. |
75 | Does whole Soy Flour Incorporated into a Muffin and Consumed at 2 Doses of Soy Protein Lower LDL Cholesterol in a Randomized , Double-Blind Controlled Trial of Hypercholesterolemic Adults? | Consuming 12.5 or 25 g protein from defatted soy flour incorporated into muffins does not reduce LDL cholesterol or other CHD risk factors in hypercholesterolemic adults. This trial was registered at clinicaltrials.gov as NCT01547585. |
76 | Does pattern of underreporting fall in a general psychiatric hospital in Japan? | Ward-specific fall rates, with further stratifications by time and location of the fall, were useful for identifying a pattern of underreporting. |
77 | Is risk of bleeding complications increased in patients undergoing rescue versus primary percutaneous coronary intervention for acute myocardial infarction? | We concluded that early or late rescue PCI and primary PCI have similar rates of MBC and overall in-hospital outcomes for patients presenting within 24 hours of acute MI. Delaying the timing of a rapid reperfusion strategy in an effort to decrease the incidence of MBC complications is generally not justified. |
78 | Does pituitary adenylate cyclase-activating peptide receptor 1 mediate anti-inflammatory effects in allergic airway inflammation in mice? | PAC1R agonists may represent a promising target for an anti-inflammatory therapy in airway diseases such as bronchial asthma. |
79 | Does potential benefit of electronic pharmacy claim data to prevent medication history errors and resultant inpatient order errors? | When current SEPCD was available for older adult patients on complex medication regimens, it had substantial potential to prevent AMH errors and resultant inpatient order errors, with greater potential to prevent more severe errors. Further study is needed to measure the benefit of SEPCD in actual use at hospital admission. |
80 | Is increased connexin43 expression in human saphenous veins in culture associated with intimal hyperplasia? | These data show that Cx43 is increased in vitro during the process of intimal hyperplasia and that fluvastatin could prevent this induction, supporting a critical role for Cx43-mediated gap-junctional communication in the human vein during the development of intimal hyperplasia. |
81 | Do a comparison of CT scan to transrectal ultrasound-measured prostate volume in untreated prostate cancer? | A strong correlation was found between CT scan and TRUS measurement of the prostate volume; however, CT consistently overestimated the prostate volume by approximately 50% compared with TRUS. |
82 | Are iL-10 plasma levels elevated after LPS injection in splenectomized A/J mice? | Our data suggest that the spleen plays an important role in modulating the inflammatory process induced by LPS, extending beyond passive clearance of encapsulated organisms. In addition, the contribution of the spleen to the inflammatory process may be influenced by the genetic background. |
83 | Is whole-brain radiation therapy beneficial as an adjuvant therapy for brain metastases compared with localized irradiation? | The present results suggest that WBRT is unnecessary and that local radiation therapy of 40 Gy or more would be the primary choice of adjuvant therapy for the majority of patients treated with surgical resection for brain metastases. |
84 | Is focal nerve enlargement the cause for increased distal motor latency in ALS : Sonographic evaluation? | Selective conduction slowing of the median nerve at the wrist in ALS is unlikely due to secondary compressive neuropathy, as seen in carpal tunnel syndrome. |
85 | Is prolonged pregnancy in women associated with attenuated myometrial expression of progesterone receptor co-regulator Krüppel-like Factor 9? | Myometrial KLF9 may contribute to the onset of human parturition through its regulation of PGR expression and inflammatory signaling networks. |
86 | Does immunolesion-induced loss of cholinergic projection neurones promote β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice? | Overall, this extended model promises further insights into the complexity of AD and contributes to novel treatment strategies also targeting the cholinergic system. |
87 | Does the -2T/C polymorphism in the adrenocorticotropin receptor gene affects stress perception of patients with alopecia areata? | These findings suggest AA in some patients may be associated with stress. The ACTHR gene -2T>C variant may be one important factor that influences stress perception of patients with AA. |
88 | Is exposure to parental verbal abuse associated with increased gray matter volume in superior temporal gyrus? | Previous studies have demonstrated an increase in STG GMV in children with abuse histories, and found a reduction in fractional anisotropy in the arcuate fasciculus connecting Wernicke's and frontal areas in young adults exposed to PVA. These findings and the present results suggest that the development of auditory association cortex involved in language processing may be affected by exposure to early stress and/or emotionally abusive language. |
89 | Does anisotropic reinforcement of acute anteroapical infarcts improve pump function? | We conclude that anisotropic reinforcement is a promising new approach to improving LV function after a large myocardial infarction. |
90 | Does tumour size predict long-term survival among women with lymph node-positive breast cancer? | The impact of decreasing tumour size on 15-year survival is much greater for women with node-positive than for women with node-negative breast cancers. Contrary to expectation, the benefit of screening is likely to be greater for women with relatively advanced breast cancer than for women with earlystage disease. |
91 | Does parents ' global rating of mental health correlate with SF-36 scores and health services satisfaction? | Given the positive association between parents' mental health and satisfaction with care, it is important to consider mental status as a covariate in interpreting satisfaction surveys. Parents' global rating of mental health appears to be a reasonable indicator of their SF-36 mental scores. |
92 | Does disordered eating behavior and mental health correlate among treatment seeking obese women? | Findings corroborate earlier work indicating that psychological distress is elevated in obese treatment seeking, bolstering the need for mental health assessment of such individuals. The feeling of ineffectiveness constitutes the major predictor of psychopathological aspects. This is an important result which may inform the development of effective interventions for obese patients and prevention of psychopathological disorders. |
93 | Does simvastatin treatment in subjects at high cardiovascular risk modulate AT1R expression on circulating monocytes and T lymphocytes? | Simvastatin induces down-regulation of the angiotensin II type 1 receptor, interferes with angiotensin II activity in immune cells and contributes to the anti-inflammatory profile of statins that can explain the therapeutic effects of these drugs. |
94 | Does human macrophage-induced vascular smooth muscle cell apoptosis require NO enhancement of Fas/Fas-L interactions? | Together, these data indicate that macrophage-derived NO is required for macrophage-induced VSMC apoptosis and that it acts by enhancing Fas-L/Fas interactions. |
95 | Are cardioprotective effects of short-term caloric restriction mediated by adiponectin via activation of AMP-activated protein kinase? | The cardioprotective effects of short-term CR are mediated by increased production of adiponectin and the associated activation of AMP-activated protein kinase. |
96 | Do mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and F. graminearum? | These findings suggest that common Arabidopsis DMR1 mediated susceptibility mechanisms occur during infection by both obligate biotrophic oomycete and hemi-biotrophic fungal pathogens, not only in vegetative but also in reproductive plant tissues. This has the potential to aid the development of cereal crops with enhanced resistance to FEB. |
97 | Is increased Th17 differentiation in aged mice significantly associated with high IL-1β level and low IL-2 expression? | We demonstrated that the proportion of Th17 cells increased in the aged mice both in naïve and memory cell populations. Elevation of IL-1R and IL-1β expression and the reduction in IL-2 and IL-2R expression in aged mice seemed to promote Th17 differentiation. Our results suggest that enhanced Th17 differentiation in aging may have a pathogenic role in the development of Th17-mediated autoimmune diseases. |
98 | Is a high normal thyroid-stimulating hormone associated with arterial stiffness , central systolic blood pressure , and 24-hour systolic blood pressure in males with treatment-naïve hypertension and euthyroid? | Treatment-naïve hypertensive males with high normal TSH and euthyroid showed higher arterial stiffness, central SBP, SVR, and SBP in ABPM and lower cardiac output and PP amplification as compared to the the low normal TSH group, but not females. |
99 | Does hydrogen sulfide inhibit formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1? | These data indicate that H2S exerts its protection against the neurotoxicity of FA through overcoming ER stress via upregulation of SIRT-1. Our findings provide novel insights into the protective mechanisms of H2S against FA-induced neurotoxicity. |
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