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stringlengths 57
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dict |
|---|---|---|---|
while erythrocyte suspensions from control subjects demonstrated resistance to hemolysis during a 3-h incubation , all samples from tocopherol-deficient cf patients showed abnormal oxidant susceptibility , evidenced by greater than 5 % hemoglobin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
6,
17
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
236,
246
]
} |
excess erythrocyte protoporphyrins of human congenital erythropoietic protoporphyria and of griseofulvin-induced murine hepatic protoporphyria were found to be associated with hemoglobin and stroma fractions in similar relationships . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
7,
18
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
176,
186
]
} |
the opposite rapid efflux of intra-erythrocytic protoporphyrin into plasma previously shown in uncomplicated erythropoietic protoporphyria occurs despite this strong hemoglobin affinity , implying continuous efficient clearance of protoporphyrin from plasma by the liver . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
35,
47
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
166,
176
]
} |
human t lymphocyte receptors for sheep red blood cells and specific antigens : are they identical sites on the cell membrane ? | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocyte",
"pos": [
6,
18
]
} | {
"id": "C0108773",
"name": "receptors",
"pos": [
19,
28
]
} |
[ human erythrocyte carbonic anhydrase b and c isoenzymes and modifications in their relationship between birth and 2nd infancy . description of an electrophoretic method without interference of hemoglobins ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
8,
19
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
195,
206
]
} |
in the hypothalamus of the adult domestic mallard , small to medium-sized perikarya are stained specifically with rabbit antiserum against cyclic somatostatin ( pap technique of sternberger ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0037659",
"name": "cyclic",
"pos": [
139,
145
]
} |
thyroid slices of goitre tissue incorporated 14c-leucine into proteins and synthesized tg and its subunits . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
0,
7
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
87,
89
]
} |
oxygen availability from the blood and the effect of phosphate replacement on erythrocyte 2,3-diphosphoglycerate and haemoglobin-oxygen affinity in diabetic ketoacidosis . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
78,
89
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
117,
128
]
} |
blood film and absolute red cell values from a previous unrelated illness were normal , proving the acquired nature of the haemoglobin abnormality . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
24,
32
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
123,
134
]
} |
regional distribution of hypothalamic luteinizing hormone-releasing hormone in proestrous rats : effects of ovariectomy and estrogen replacement . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
25,
37
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
38,
75
]
} |
the majority ( 75 % ) of the iodinated macromolecular product accumulated by follicular thyroid cells , by monolayer thyroid cells stimulated with thyrotropin for a prolonged period , or by thyroid cells treated with dibutyryl camp from the onset of culture has the characteristics of 19 s thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
88,
95
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
290,
303
]
} |
ovariectomized rhesus monkeys bearing hypothalamic lesions which had abolished endogenous lhrh production , as evidenced by a profound reduction in gonadotropin secretion , but in which lh and fsh secretion was reestablished by a chronic intermittent iv infusion of synthetic lhrh ( 1 microgram/min for 6 min every hour ) were used to investigate the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
38,
50
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
276,
280
]
} |
pulsatile lh secretion was re-established in ovariectomized monkeys bearing hypothalamic lesions by an intermittent infusion of lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
76,
88
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
128,
132
]
} |
in the current investigation , subcellular particles ( synaptosomes ) of hypothalamic homogenates were isolated by differential centrifugation and discontinuous sucrose density gradient fractionation and found to be rich in lhrh , trh , and the neuronal marker , norepinephrine ( ne ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
73,
85
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
224,
228
]
} |
moreover , the immunological activity , size , and charge characteristics of anglerfish islet srif appear to be similar to those of mammalian hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
142,
154
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
155,
159
]
} |
lh and prl peaks were observed at late proestrus when da-ti and ne-ti reached their lowest values and hypothalamic lhrh concentration was failing . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
102,
114
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
115,
119
]
} |
release of gonadotropin-releasing hormone ( gnrh ) was studied by incubating individual rat hypothalami for 60 min , after a 30-min preincubation period , and measuring gnrh in the medium by immunoassay . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
92,
103
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
169,
173
]
} |
using this clearance and the mean serum tg concentration in these rats , a daily thyroidal release rate of about 201 microgram tg/100 g bw would be required to provide the t4 metabolized daily by the rat , the tg released into the circulation comprises about 7 % of the total rat tg produced in a 24-h period . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
81,
90
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
280,
282
]
} |
in the red blood cell exist a binding equilibrium of atp and 2,3-dpg with hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
7,
21
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
74,
84
]
} |
ovocyclin , duogynon forte and fertyl treatments bring about anaemia in this fish , i.e . a decrease in rbc number , hb content and pcv was clearly marked out . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
104,
107
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
117,
119
]
} |
changes in hypothalamic lh-rh content and blood levels of lh-rh , gonadotropin and estradiol during the preovulatory stage of rat estrous cycle . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
11,
23
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
58,
63
]
} |
in order to investigate the sequence of events concerning gonadotropin surge , serum lh , fsh and estradiol concentrations were measured during the rat estrous cycle as well as hypothalamic and blood levels of lh-rh in the preovulatory stage . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
177,
189
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
210,
215
]
} |
these studies indicate that the elevation of serum estradiol was followed by the release of lh-rh from the hypothalamus and the lh-rh may be responsible for the preovulatory discharge of gonadotropin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
107,
119
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
128,
133
]
} |
on the whole , the erythrocyte values were quite uniform within a narrow range of variation , while the hemoglobin content was comparatively irregular within a wider range of variation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
19,
30
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
104,
114
]
} |
the major changes in the levels of mean values of both the red cells and the hemoglobin , however , were found to be statistically significant . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
59,
68
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
77,
87
]
} |
the directions or trends in the levels of the erythrocyte and hemoglobin mean values did not necessarily move in opposite directions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
46,
57
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
62,
72
]
} |
the general levels of the erythrocyte and hemoglobin mean values were not identical for two consecutive years , those of 1927-28 being higher than those of 1928-29 . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
26,
37
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
42,
52
]
} |
the fluctuations of both red cell and hemoglobin mean values observed in one group of animals were also usually observed in another group examined during the same months . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
25,
33
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
38,
48
]
} |
( c ) small doses elicited the same kind of response except that the normoblastosis was less marked , the decrease of red cells and hemoglobin minimal or absent , the increase of red blood cells and hemoglobin marked in most instances . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
118,
121
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
199,
209
]
} |
hypothalami taken from rats , adrenalectomized 7-14 days previously , released several-fold more crh into the medium during electrical stimulation than the initial content of the tissue , showing that the tissue was capable of synthesizing crh in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
0,
11
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
240,
243
]
} |
the hypothalami taken from intact rats released considerably less crh into the medium than tissue taken from 12 to 14 day adrenalectomized rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
4,
15
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
66,
69
]
} |
it is therefore proposed that the delayed negative feed-back action of corticosterone at the hypothalamic level is by the suppression of crh synthesis and that the effect of secretion is secondary to the effect on synthesis.4 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
93,
105
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
137,
140
]
} |
this evidence suggests that gaba may play a role in controlling the discharge of hypothalamic luteinizing hormone releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
81,
93
]
} | {
"id": "C0023610",
"name": "luteinizing hormone",
"pos": [
94,
113
]
} |
rapid transient efflux of phosphate ions from pancreatic islets as an early action of insulin secretagogues . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
46,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
86,
93
]
} |
[ erythrocyte count in children and adults -- normal values for hemoglobin content , relative erythrocyte volume and median corpuscular hemoglobin concentration of erythrocytes ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
2,
13
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
136,
146
]
} |
binding analyses of the soluble cd2 molecule indicate that it binds specifically to a known cell-surface ligand for cd2 at a relatively low affinity , thus suggesting that t cell-target adhesion mediated by cd2 and its ligand depends on multimeric attachment between an array of cd2 molecules and their cognate ligands . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
172,
178
]
} | {
"id": "C0108773",
"name": "cd2 molecules",
"pos": [
279,
292
]
} |
the rheumatoid t cells are hypo-responsive after stimulation with antigens and anti-cd3 antibodies which indicate that the cd3-tcr complex has been modulated in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
15,
22
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
127,
130
]
} |
the drug has a specific effect on t-lymphocytes in which it seems to prevent the transcription of genes for several lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
36,
47
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
116,
127
]
} |
these findings suggest that the hypothalamus may regulate the cyclo ( his-pro ) binding sites in the liver probably by controlling pancreatic ss secretion , since a vmh-lesion is reported to cause hypersecretion of pancreatic ss . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
32,
44
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
226,
228
]
} |
poly ( a ) mrna fractions from hypothalami ( 40-50 ) of intact , castrated plus vehicle , and castrated plus t group were isolated , blotted on nitrocellulose paper and hybridized with 32p-end labelled lh-rh oligonucleotides ( 29 mer ) which is complementary to the rat lh-rh mrna . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
31,
42
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
270,
275
]
} |
in addition , lh-rh contents and release from hypothalami were studied , to examine the correlation with lh-rh gene expression and secretory activity of lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
46,
57
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
153,
158
]
} |
hypothalamic lh-rh release after acute and chronic treatment with morphine studied in a combined in vivo/in vitro model . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
13,
18
]
} |
within 16-24 h after morphine treatment , basal lh-rh release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats , suggesting that dependence had occurred in the neural mechanisms underlying lh-rh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
118,
129
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
239,
244
]
} |
addition of the opioid antagonist naloxone in vitro resulted in a 220 % increase in the release of lh-rh by hypothalami exposed to morphine for 48 h in vivo , whereas it caused a 50 % reduction in lh-rh release from tissues exposed to morphine for 96 h in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
108,
119
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
197,
202
]
} |
hypothalamic somatostatin concentration was determined in 6.5 to 9 months old male and female genetically obese fatty ( fa/fa ) and lean ( fa/- ) zucker rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
13,
25
]
} |
the effect of prolonged stress on the hypothalamic luteinizing hormone-releasing hormone ( lhrh ) in the anoestrous ewe . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
38,
50
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing",
"pos": [
51,
80
]
} |
a study was performed to examine the effect of the intermittent long-term ( 20 min/h daily during 3 consecutive days ) electric stress ( footshocks ) on the hypothalamic lhrh in anoestrous ewe . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
157,
169
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
170,
174
]
} |
on the third day , immediately after the last stimulation , the animals were decapitated and the hypothalami and pituitaries were taken for analysis of lhrh and lh by immunocytochemistry ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
97,
108
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
152,
156
]
} |
mg participates in immune responses in numerous ways : as a cofactor for immunoglobulin synthesis , c ' 3 convertase , immune cell adherence , antibody-dependent cytolysis , igm lymphocyte binding , macrophage response to lymphokines , t helper-b cell adherence , binding of substance p to lymphoblasts and antigen binding to macrophage rna . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
178,
188
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
222,
233
]
} |
in this preliminary study it is not possible to evaluate the role of these cells in the disease process , but it is of interest that in some ra patients there is an overabundance of both t cells that arise early in ontogeny ( tcr gamma delta cells ) and b cells that arise early in ontogeny , the cd5 b cell . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
187,
194
]
} | {
"id": "C0085246",
"name": "tcr gamma delta",
"pos": [
226,
241
]
} |
fibronectin , basement membrane heparan sulphate proteoglycan and type iv collagen are more widespread in their distribution than laminin , and are even present between mesenchymal cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
14,
31
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
66,
82
]
} |
neither acute nor chronic morphine administration altered either ( a ) hypothalamic parvocellular or magnocellular crf mrna , or ( b ) anterior pituitary or pars intermedia pomc mrna . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
71,
83
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
115,
118
]
} |
a kinetic analysis of the inhibition of human prostatic 5 alpha-reductase by 4-hydroxyandrostenedione and related steroids . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
46,
55
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
56,
73
]
} |
the inhibition of human prostatic 5 alpha-reductase by androstenedione ( a ) , 4-hydroxyandrostenedione ( 4-oh-a ) , and 4-methoxyandrostenedione ( 4-meo-a ) was studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
24,
33
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
34,
51
]
} |
expression of receptors for the hypothalamic regulatory peptide , gonadotrophin-releasing hormone ( gnrh ) , was investigated by intracellular recording from xenopus oocytes injected with poly ( a ) + mrna isolated from rat anterior pituitary glands . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "gonadotrophin-releasing hormone",
"pos": [
66,
97
]
} |
in separate experiments in vitro fts , but not two other thymic peptides , thymopoietin and thymosin alpha 1 , caused a dose-related release of lh from pituitary tissue . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymic",
"pos": [
57,
63
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
75,
87
]
} |
red cell sod generates ( and is , therefore , exposed to ) h2o2 on a continuous basis , by dismutation of superoxide ( from hemoglobin autooxidation and the interaction of hemoglobin with numerous xenobiotics ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
172,
182
]
} |
individual t cells express the cd3 molecule in association with alternative gamma delta or alpha beta heterodimeric t cell receptors ( tcr ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
11,
18
]
} | {
"id": "C0085247",
"name": "alpha beta",
"pos": [
91,
101
]
} |
moreover , pre t cells within this group indicate that delta tcr rearrangement can occur prior to the activation of gamma , beta , and alpha loci . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
15,
22
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
61,
64
]
} |
these studies demonstrate that the optimal activation of cd4+ t cells involves recognition of peptide fragments presented by class ii mhc molecules and accessory signals derived from the antigen presenting cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
57,
60
]
} | {
"id": "C0019630",
"name": "class ii mhc",
"pos": [
125,
137
]
} |
stress-induced changes in corticotropin-releasing factor ( crf ) in immune tissues and hypothalamus : studies toward defining a role for crf in neuroimmunomodulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
87,
99
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
137,
140
]
} |
one of the earliest increases observed in the myoepithelial-like pathway in vitro is that due to a novel protein p9ka , whereas the major increases in thy-1 antigen and the basement membrane proteins laminin and type iv collagen occur at later steps . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
173,
190
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
212,
228
]
} |
an erythrocyte contains about 3500 mol glutathione peroxidase , or , for every 80000 mol hemoglobin one mol glutathione peroxidase . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
3,
14
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
89,
99
]
} |
in the milk-only group , the plasma iron concentration ( p-fe ) , blood hemoglobin concentration ( b-hb ) , red blood cell count ( b-rbc ) , and mean corpuscular volume ( mcv ) declined continuously , whereas the hemoglobin mass of the blood ( hb-mass ) remained unchanged , and the blood platelet count ( b-plts ) , plasma platelet count ( p-plts ) , and the estimated platelet release to the blood ( plt-release ) showed a continuous rise . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
133,
136
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
213,
223
]
} |
in spite of normal thymic histology , thymocyte subsets and blastogenesis , thymus gland products ( thymosins ) have yet to be studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus gland",
"pos": [
76,
88
]
} | {
"id": "C0040106",
"name": "thymosins",
"pos": [
100,
109
]
} |
in the present report , thymus gland function was studied by measuring thymosin alpha 1 levels at one time point in the bb rat compared with control rates , and bb rat responses to exogenous thymosin ( thymosin fraction 5 ) were observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus gland",
"pos": [
24,
36
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
202,
210
]
} |
in the second experimental model , chick-rat epithelial-mesenchymal recombinants developed as intracoelomic grafts were used , and the immunocytochemical detection of a basement membrane protein , type-iv collagen , was performed with species-specific antibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
169,
186
]
} | {
"id": "C0009333",
"name": "type-iv",
"pos": [
197,
204
]
} |
these observations emphasize the role of tissue interactions in the formation of a basement membrane and show that the mesenchymal compartment is the principal endogenous source of type-iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
83,
100
]
} | {
"id": "C0009333",
"name": "type-iv collagen",
"pos": [
181,
197
]
} |
it is suggested that this d1 receptor is responsible for a long-term regulation of hypothalamic hormone release inter alia lhrh release from the terminal and preterminal parts of the lhrh axons in the lateral palisade zone and subependymal layer , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
183,
187
]
} |
results of this study show that ( 1 ) progesterone can stimulate in vitro gnrh and 5-ht release from hypothalamic tissue slices of ovariectomized rats primed with estrogen and ( 2 ) the 5-ht receptor antagonist mianserin blocks the ability of progesterone to augment in vitro gnrh release from these tissue slices . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
101,
113
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
276,
280
]
} |
the apparent intracellular localization of dye and the extent of uptake at a low dye concentration could be manipulated , respectively , by varying the hemin ( or protoporphyrin ix ) concentration in the medium and by adding red blood cell extract ( or hemoglobin ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
225,
239
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
253,
263
]
} |
the effects of a protein-free diet , hydrocortisone and insulin on the sedimentation of muscle ribosomes were found to be in accord with their net effects on muscle protein synthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
88,
94
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
158,
172
]
} |
effect of hypoglycemia on the content of pituitary growth hormone ( gh ) and hypothalamic growth hormone-releasing factor ( ghrf ) in the rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
77,
89
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
90,
121
]
} |
the mean molar ratio of vco to vheme ( rate of circulating heme catabolism , determined from ( 51 ) cr red cell survival curves ) was 3.0 +/- 0.6 ( se ) , indicating that most of the co originated from sources other than circulating erythrocyte hemoglobin , in contrast to previous findings in patients with hemolytic anemia , where vco paralleled vheme closely . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
233,
244
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
245,
255
]
} |
[ spectral properties of hemoglobin in different parts of the erythrocyte and the distribution of methemoglobin in it after a partial methemoglobin formation ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
62,
73
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
134,
147
]
} |
since glucose is known to raise islet intracellular levels of camp , which is known to be an inhibitor of cellular proliferation , the observed glucose stimulation of both islet-cell dna replication and insulin production appeared conflicting . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet-cell",
"pos": [
172,
182
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
203,
210
]
} |
the solubility of deoxyhemoglobin s was unaffected by the presence of red cell membrane ghosts , inside-out red cell vesicles , or inside-out vesicles enriched in erythrocyte spectrin and actin ( bands 1 , 2 , and 5 ) in the hemoglobin solution . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
163,
174
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
225,
235
]
} |
to study their rate of formation and stability inside red cells , pyridoxal-hb and plp-hb were measured in lysates from treated normal and sickle erythrocytes using isocratic high pressure liquid chromatography on bio-rex 70 . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
54,
63
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
87,
89
]
} |
furthermore , although albumin and fibrinogen released by platelets bound to fibronectin-coated substrata as well as did thrombospondin , these two proteins crosslinked at much lower levels than seen for thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
58,
67
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
204,
218
]
} |
lipid peroxidation of erythrocyte membrane induced by xanthine oxidase system : modification of superoxide dismutase effect by hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
22,
33
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
127,
137
]
} |
the immune response to connective tissue components of basement membrane ( type iv collagen and laminin ) and to interstitial collagen ( type i ) has been examined in human and murine systems . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "connective tissue",
"pos": [
23,
40
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
137,
141
]
} |
the qualitative changes of islet structure accompanying insulin cell reduction in iddm were not considered in the present study . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
27,
32
]
} | {
"id": "C0021641",
"name": "iddm",
"pos": [
82,
86
]
} |
the study was performed both in control or sham operated animals and after transecting the major projections of hypothalamic srif-containing neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
112,
124
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
125,
129
]
} |
transection of hypothalamic periventricular efferents resulted in a 58 % depletion of srif content in the locus coeruleus , while concentrations of the peptide in other areas were unaffected . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
86,
90
]
} |
the apparent inability of the chicken erythrocyte to alter readily its concentration of inositol-p5 suggests that the hemoglobin oxygen delivery system of birds may be less adaptable to changing oxygen requirements by regulating the concentration of hemoglobin modulator than is that of the mammals . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
38,
49
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
250,
260
]
} |
[ somatomedin inhibition of the growth hormone secretion stimulated by the hypothalamic factor somatocrinin or the synthetic peptide hpgrf ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
75,
87
]
} | {
"id": "C0037668",
"name": "somatocrinin",
"pos": [
95,
107
]
} |
in the in vitro monolayer pituitary cell culture system somatomedin-c and igf-i are practically equipotent to inhibit the secretion of growth hormone stimulated by hypothalamic growth hormone releasing factor ( grf ) or the synthetic peptide hpgrf-44 ( 3-200 x 10 ( -12 ) m ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
164,
176
]
} | {
"id": "C0037668",
"name": "growth hormone releasing factor",
"pos": [
177,
208
]
} |
eleven chimeric plasmids have been constructed which direct the synthesis of mature human fibroblast ( ifn-beta 1 ) or leukocyte interferon ( ifn-alpha a ) proteins under the control of the e. coli trp promoter . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
90,
100
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
103,
111
]
} |
the animals submitted to this experiment showed an increase of thyroid weight ( 39 % ) and a decrease of its content in water soluble proteins , including thyroglobulin and precursors . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
63,
70
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
155,
168
]
} |
high-molecular-weight dna from cultured human fibroblast cells and tissues was analyzed with the restriction endonucleases msp i and hpa ii for the presence of methylated sites in the sequences flanking the beta-interferon gene . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0015980",
"name": "beta-interferon",
"pos": [
207,
222
]
} |
in order to clarify the pancreatic endocrine functions in mild chronic pancreatitis , the response of insulin to oral glucose load and the response of glucagon and human pancreatic polypeptide ( hpp ) to insulin-induced hypoglycemia were investigated in five normal controls and eight patients with chronic pancreatitis but without diabetes mellitus . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic endocrine",
"pos": [
24,
44
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
204,
211
]
} |
indirect experiments , both in the animal and the human , suggest that the arcuate nucleus located in the medio-basal hypothalamus secretes gnrh by pulses ( with increasing amplitude , and probably frequency ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
118,
130
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
140,
144
]
} |
analysis of the 19f-nmr chemical shifts and linewidths of mefloquine in the presence of red cells , red-cells ghosts and hemoglobin indicates restricted mobility of the drug in the membrane-bound state and slow exchange with the extracellular medium . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red-cells",
"pos": [
100,
109
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
121,
131
]
} |
the ontogenesis of adenohypophyseal dopamine receptors , assessed by haloperidol-displaceable [ 3h ] didydroergocryptine ( dhe ) binding of 1- , 12- , 20- , 28-day-old female rats was studied in correlation with the prolactin releasing effect of haloperidol ( 1 mg/kg ) , a dopaminergic antagonist . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
19,
35
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
216,
225
]
} |
islet cell responsiveness ( c-peptide and glucagon ) to oral glucose ( ogtt ) , intravenous glucose ( ivgtt ) , and arginine infusion was studied sequentially in a 24-yr-old nonobese patient with iddm in prolonged remission interrupted by an episode of diabetic ketoacidosis and followed by a second transient ( 6 mo ) partial recovery of beta cell function . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
0,
10
]
} | {
"id": "C0021641",
"name": "iddm",
"pos": [
196,
200
]
} |
in addition , the posterior lobectomy-induced rise in plasma lh appears to be dependent on the presence of lhrh , but it remains to be determined whether a posterior pituitary substance ( s ) alters hypothalamic release of or anterior pituitary responsiveness to lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
199,
211
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
263,
267
]
} |
the localization of grf-immunoreactive structures in the hypothalamus and median eminence reinforces the view that grf plays a physiological role in the regulation of pituitary function . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
57,
69
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
115,
118
]
} |
it is concluded that carbamylcholine ( 10 ( -5 ) m ) inhibits stimulated thyroid secretion at a step beyond camp accumulation by blocking pseudopod formation and not by inhibiting thyroglobulin hydrolysis or hormone diffusion . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
73,
80
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
180,
193
]
} |
from stopped flow data , the oxidation was concluded to occur by way of two-electron transfer and the rate constant for the reaction of thyroid peroxidase compound i with thyroglobulin was estimated to be 1.0 x 10 ( 7 ) m-1 s-1 . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
136,
143
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
171,
184
]
} |
a case for hypothalamic acromegaly : a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
11,
23
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
124,
155
]
} |
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