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dict |
|---|---|---|---|
orosomucoid ( or ) ( alpha 1-acid glycoprotein ) , an acute-phase reactant , was elevated in these sera , and a positive correlation existed between the or level in the sera and its immunosuppressive capacity . | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
54,
74
]
} | {
"id": "C0029297",
"name": "or",
"pos": [
153,
155
]
} |
measurement of the relative number of thy-1 molecules per cell by antiserum absorption techniques suggested that a neoplastic stem cell line , rat mammary ( rama ) 25 , contained about 3 x 10 ( 5 ) thy-1 molecules per cell in a form not directly accessible at the cell surface to anti-thy-1 antibodies ; | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
66,
75
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
291,
301
]
} |
seven complex mixtures were obtained as dichloromethane extracts of collected particulate emissions from three diesel-fueled automobiles , a heavy-duty diesel engine , a nonleaded gasoline-fueled automobile , a coke oven battery , and a roofing tar pot . | NA | {
"id": "C1258022",
"name": "complex mixtures",
"pos": [
6,
22
]
} | {
"id": "C0039315",
"name": "tar",
"pos": [
245,
248
]
} |
unstable angina occurred in more than 1/3 of patients classified as definite or probably angina pectoris . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
0,
15
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
89,
104
]
} |
the effect of long-term treatment over 40 weeks with bezafibrate on lipids and lipoproteins was investigated in 27 patients with primary hyperlipoproteinemias ( hlp ) ( 12 patients with hlp type iv , 7 patients with type iib , 3 patients with type iia , 4 patients with type v and 1 patient with type iii ) . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
68,
74
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
79,
91
]
} |
these studies included : gastric proenzyme , pepsinogen , and pancreatic enzymes , amylase and lipase , in blood and urine , trypsin in blood , intestinal enzymes , invertase and glycyl-l-leucine dipeptidase in feces , and lipids in feces . | NA | {
"id": "C0014436",
"name": "proenzyme",
"pos": [
33,
42
]
} | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
45,
55
]
} |
the effects of 4-week periods of treatment , with equivalent doses of acebutolol ( 500 mg daily ) and pindolol ( 15 mg daily ) , on plasma noradrenaline , adrenaline , and dopamine , and oxygen uptake at rest , during submaximal steady-state exercise and maximal exercise , and 5 min after exercise , were studied in 11 moderately hypertensive men aged 26-40 years , using a single , crossover design . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
139,
152
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
155,
165
]
} |
the sustained haemodynamic effects of prazosin ( 20-30 mg ) and metoprolol ( 400-800 mg ) alone and combined ( half-dose ) were evaluated in five patients with hypertension , left ventricular hypertrophy , and radiological cardiac enlargement . | NA | {
"id": "C0149721",
"name": "left ventricular hypertrophy",
"pos": [
175,
203
]
} | {
"id": "C0018800",
"name": "cardiac",
"pos": [
223,
230
]
} |
epinephrine in the plasma was not detectable , and plasma norepinephrine concentration was not increased after hemorrhage . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
58,
72
]
} |
together , this suggests elevated sympathetic activity and enforced vasoconstriction via postjunctional alpha 1-adrenoceptors in essential hypertension . beta-adrenoceptor-mediated cardiovascular responses decrease with age and even more with high blood pressure , which contributes to unopposed alpha-adrenoceptor-mediated vasoconstriction . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenoceptors",
"pos": [
104,
125
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
296,
314
]
} |
the effects of 3 quinazoline alpha-adrenoreceptor antagonists , prazosin , trimazosin , and uk-33,274 , on lying blood pressure ( bp ) , bp response to 60 degrees tilt , pressor response to noradrenaline , phenylephrine , and exercise ( isometric and dynamic ) were measured in a double-blind study in 6 volunteers . | NA | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
17,
28
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
64,
72
]
} |
a group of centrally acting clonidine-like drugs are classified in terms of their selectivity for the alpha 2-adrenoreceptors , and it is suggested that differences between alpha-adrenoreceptors in various tissues may allow development of highly selective alpha 2-adrenoreceptor agonists for specific tissue sites such as the juxtaglomerular cells and brainstem nuclei controlling blood pressure . | NA | {
"id": "C0034784",
"name": "alpha-adrenoreceptors",
"pos": [
173,
194
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoreceptor",
"pos": [
256,
278
]
} |
plasma adrenaline ( 301 +/- 480 pg/ml ) , noradrenaline ( 1,312 +/- 1,382 pg/ml ) , and renin activity ( 22 +/- 30 ng/ml/h ) were in the range observed with pheochromocytoma ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
42,
55
]
} |
the recent interest in the characterization and functional , role of alpha-adrenoceptors has prompted us to study the following different , although interdigitated , lines of research : ( a ) the functional role of calcium ions in the process of vasoconstriction , induced by alpha 2-adrenoceptor stimulation . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
69,
88
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptor",
"pos": [
276,
296
]
} |
a great deal of experimental observations at alpha-adrenoceptors may be explained if two points are considered : ( 1 ) the alpha 1-/adrenoceptor ratio ( selectivity ratio ) of a given drug and ( 2 ) the ratio of alpha 1-/adrenoceptors in the target organ or tissue . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
45,
64
]
} | {
"id": "C0001638",
"name": "alpha 1",
"pos": [
212,
219
]
} |
neonatal 6-hydroxydopamine ( 6-ohda ) treatment was used to destroy the noradrenergic nerve endings in rat cerebral cortex and thus give some insight into the development and regulation of alpha-adrenoceptor subtypes , which in turn provides information concerning the anatomical localization of alpha 1- and alpha 2-adrenoceptors . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
189,
207
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptors",
"pos": [
309,
330
]
} |
expect for heparin , however , all the glycosaminoglycans studied chondroitin 4-sulphate , chondroitin 6-sulphate , dermatan sulphate and hyaluronic acid interfered with the uptake of [ 3h ] thymidine into the cells . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
11,
18
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
39,
57
]
} |
ganglia dissected from the marine bivalve , macrocallista nimbosa , were pooled and incubated in a series of seawater media designed to promote or inhibit the release of the neuropeptide phe-met-arg-phe-nh2 ( fmrfamide ) . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
174,
186
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
209,
218
]
} |
although the in vivo release sites have not yet been localized , these findings already show that the endogenous neuropeptide fmrfamide can be characterized as a neurohormone or as a neurotransmitter in macrocallista . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
113,
125
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
126,
135
]
} |
adrenergic agonists competed for binding of [ 3h ] dhe and [ 3h ] prazosin in the order : 1-epinephrine greater than 1-norepinephrine greater than d-epinephrine greater than d-norepinephrine greater than 1-isoproterenol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
92,
103
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
176,
190
]
} |
a series of catecholamines inhibit binding of both ligands with a potency in the order epinephrine greater than norepinephrine much greater than isoproterenol , corresponding with the activity of these agents at alpha adrenoceptors in blood vessels . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
12,
26
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
145,
158
]
} |
a series of catecholamines inhibit binding of both ligands with a potency in the order epinephrine greater than norepinephrine much greater than isoproterenol , corresponding with the activity of these agents at alpha adrenoceptors in blood vessels . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
87,
98
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} |
competition for binding in both instances is stereoselective . l-phenylephrine has similar potencies in inhibiting ( 3h ) prazosin and ( 3h ) yohimbine specific binding whilst the imidazoline related partial alpha adrenergic agonists clonidine and guanfacine are more potent in inhibiting ( 3h ) yohimbine specific binding . | NA | {
"id": "C1449836",
"name": "imidazoline",
"pos": [
180,
191
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
234,
243
]
} |
the adenosine derivative , n6-phenylisopropyladenosine ( pia ) , which inhibits adenylate cyclase in adipocyte membranes by a gtp-dependent and sodium-amplified process , was studied on gtpase activity in hamster adipocyte ghosts . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
4,
13
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
30,
54
]
} |
this discriminative effects of cyclorphan were studied in pigeons trained to discriminate 0.32 mg/kg ethylketazocine , 1.8 mg/kg cyclazocine , or 32 mg/kg naltrexone from saline . | NA | {
"id": "C0079314",
"name": "ethylketazocine",
"pos": [
101,
116
]
} | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
129,
140
]
} |
thus , cyclorphan has discriminative effects that are similar to those of both ethylketazocine and at 20 fold higher doses , cyclazocine . | NA | {
"id": "C0079314",
"name": "ethylketazocine",
"pos": [
79,
94
]
} | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
125,
136
]
} |
processing of synthetic somatostatin-28 and a related endogenous rat hypothalamic somatostatin-like molecule by hypothalamic enzymes . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
24,
39
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
82,
94
]
} |
synthetic somatostatin-28 ( s-28 ) as well as a related endogenous rat hypothalamic somatostatin-like compound ( 3k sli ) were incubated with hypothalamic extracts from which endogenous somatostatin-like immunoreactivity ( sli ) had been removed by immunoabsorption . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
10,
25
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
186,
198
]
} |
the reaction products were analyzed by gel chromatography , hplc as well as two different radioimmunoassay for tetradecapeptide somatostatin ( s-14 ) in which s-28 crossreacted either 100 % ( ria r149 ) or less than 0.001 % ( ria s39 ) . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
128,
140
]
} | {
"id": "C0074854",
"name": "s-28",
"pos": [
159,
163
]
} |
circulating angiotensin is produced by the action of renin from the kidneys on circulating angiotensinogen . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
12,
23
]
} | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
91,
106
]
} |
[ study of the iodine-absorptive function and topography of the thyroid gland with sodium iodide labeled with short-life i-123 ] . | NA | {
"id": "C0021966",
"name": "iodine",
"pos": [
15,
21
]
} | {
"id": "C0037521",
"name": "sodium iodide",
"pos": [
83,
96
]
} |
the fatty acid composition of total cellular lipids and lipid a of lipopolysaccharides was studied in providencia alcalifaciens and p. stuartii . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
56,
63
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
67,
86
]
} |
differences were also established in the content of fatty acids in lipid a of lipopolysaccharides from p. alcalifaciens and p. stuartii . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
67,
74
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
78,
97
]
} |
no differences from normal were seen in the percentage of okt3 , okt4 , and okt8 cells or in the ratios of okt4/okt8 cells in peripheral blood mononuclear cells ( pbmc ) from all cancer patients , patients with localized disease , or patients with advanced disease . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
126,
160
]
} |
probabilities of the incorporation of tritium label into various amino acids with alanine as a standard have been determined by `` '' bombing '' '' solid targets with a 3h-atom beam ( 2 000 k ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
65,
76
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
82,
89
]
} |
rejection of noncognate aminoacyl adenylate-enzyme complexes is connected neither with the enzymatic hydrolysis of aminoacyl adenylate nor with the competition of non-cognate aminoacyl adenylate and the added amino acid for the enzyme binding site . | NA | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
44,
60
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
228,
234
]
} |
different types of viral rna were identified in the cytoplasmic fraction whose sedimentation values were nearly the same as for rsv-specific rna in virus-producing chicken cells . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
19,
28
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
141,
144
]
} |
the relative content in these fractions of non-transcribed dna sequences was established by hydridization with a mouse satellite dna , and the relative content of transcribed dna sequences -- by hydridization with dna synthesised on the total poly ( a ) mrna . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
119,
132
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
214,
217
]
} |
in cultured monolayers of fibroblasts , the infected cells are selected out and aggregate engulfing one another to form giant multinucleated structures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
26,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
53,
58
]
} |
however , electrophoretic analysis of these cells showed normal amounts of vimentin , the fibroblast if subunit protein . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
44,
49
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
90,
100
]
} |
since recent observations indicate that treatment with high-dose intravenous polyvalent intact immunoglobulin leads to a rapid reversal of thrombocytopenia in the idiopathic thrombocytopenic purpura ( itp ) of childhood , we decided to apply this treatment to adults with itp and to test the possibility that the effect of the immunoglobulin might be attributable to transient blockade of the reticuloendothelial system . | NA | {
"id": "C0085297",
"name": "intravenous",
"pos": [
65,
76
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
327,
341
]
} |
an enzyme system with requirements similar to those for replication of phage fd replicative form ( rf ) dna in bacteriophage fd-infected cells has been reconstituted with purified fd gene 2 protein , and dna polymerase iii holoenzyme , dna binding protein i and rep-protein ( rep-helicase ) of escherichia coli . | NA | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
236,
255
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
266,
273
]
} |
in our experimental work we intended to study the effect of certain anthracycline antibiotics , like adriamycin , daunomycin , carminomycin on the rna dependent dna polymerase , i.e . reverse transcriptase ( rt ) system . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
114,
124
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
127,
139
]
} |
in our work we have shown that carminomycin , in contrast to adriamycin and daunomycin , possesses a highly specific inhibitory effect on the rt enzyme system . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
31,
43
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
76,
86
]
} |
we have studied the induction of a granulocyte-associated leukocytosis ( leukemoid reaction ) in c3ha , c57b1/6 , and dba/2 mice by a number of transplantable tumors of different origin . | NA | {
"id": "C0023518",
"name": "leukocytosis",
"pos": [
58,
70
]
} | {
"id": "C0023501",
"name": "leukemoid reaction",
"pos": [
73,
91
]
} |
moreover , the membrane cyclase system was more responsive to activation by gtp , guanyl-5'-yl-imidodiphosphate and mn-atp . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
76,
79
]
} | {
"id": "C0018366",
"name": "guanyl-5",
"pos": [
82,
90
]
} |
intraperitoneal injection of [ 4-36cl , 2-14c ] p-chlorophenylalanine ( pcpa ) ( 300 mg/kg ) in rats revealed absence of chlorine in pure hepatic phenylalanine hydroxyase , while the carbon label appeared a 1 -- 4 moles/mole of [ 14c ] tyrosine in the inactivated phenylalanine and cerebral tryptophan-5-hydroxylase . | NA | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
48,
69
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
264,
277
]
} |
repeated injections of p-chlorophenylacetic acid had no effect on phenylalanine or tryptophan-hydroxylase , administration of pcpa did not change the levels of cerebral biopterins . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
66,
79
]
} | {
"id": "C0030135",
"name": "pcpa",
"pos": [
126,
130
]
} |
diurnal variations , ranging over a twofold difference in concentrations of dopamine , norepinephrine and epinephrine , occur in the rat posterior pituitary gland during a 24-hour period . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
87,
101
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
106,
117
]
} |
dopamine concentrations rapidly returned to high levels at the onset of the daylight period , whilst the increase in norepinephrine and epinephrine concentrations was delayed . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
117,
131
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
136,
147
]
} |
35 male sprague-dawley rats , 18 months old , were injected subcutaneously with the catecholamine precursor , l-dihydroxyphenylalanine ( l-dopa ) ( 100 mg/kg , twice daily ) , or vehicle alone , for 8 days in an attempt to increase the amplitude of growth hormone ( gh ) pulses in old male rats . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
84,
97
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
112,
134
]
} |
these data indicate that l-dopa can increase the amplitude of gh pulses and elevate mean plasma gh in old male rats to levels present in young male rats , probably by increasing hypothalamic catecholamines . | NA | {
"id": "C0013023",
"name": "l-dopa",
"pos": [
25,
31
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
191,
205
]
} |
the data gathered indicate that benserazide-induced hyperprolactinemia in parkinsonian patients could be due to a direct effect of the drug at the hypothalamic level and consequently to an inhibition of dopamine decarboxylation in the tuberoinfundibular dopaminergic system . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
203,
211
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
254,
266
]
} |
5,7-dihydroxytryptamine ( 5,7-dht ) , which reacts with a monoclonal antibody raised against 5-hydroxytryptamine ( 5-ht ) , has been used to increase the sensitivity of the immunohistochemical detection by this antibody of central 5-ht nerves in the rat brain . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
58,
77
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
211,
219
]
} |
in an effort to test the hypothesis that benzodiazepine action may be due to the inhibition of adenosine uptake , the inhibition of [ 3h ] nbi binding by diazepam , clonazepam and chlordiazepoxide was tested . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
41,
55
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
180,
196
]
} |
the polyamines putrescine , cadaverine , spermidine , spermine , and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
4,
14
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
83,
88
]
} |
solely the mean of the spermidine values of postoperative patients with or without medical therapy and the spermine mean value for postoperative patients in tumor stage i and iii were elevated . | NA | {
"id": "C0037871",
"name": "values",
"pos": [
34,
40
]
} | {
"id": "C0037874",
"name": "mean",
"pos": [
116,
120
]
} |
the form of experimental allergic uveoretinitis induced by sensitization with retinal 's ' antigen in rats actually begins as a pars planitis and juxtapapillary choroiditis . | NA | {
"id": "C0030593",
"name": "pars planitis",
"pos": [
128,
141
]
} | {
"id": "C0008526",
"name": "choroiditis",
"pos": [
161,
172
]
} |
a more quantitated examination of csf proteins ( albumin , alpha 2-macroglobulin , iga , igg and igm ) showed significantly increased values among the tumour patients , but the findings were not of any significant clinical value in the diagnosis of tumours . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
38,
46
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
49,
56
]
} |
experiment ii compared cancer pain patients matched with benign pain patients on intensity of pain report on the affective dimension of the mpq . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
23,
34
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
94,
98
]
} |
these data suggest that cancer pain patients employ different criteria than benign pain patients in selecting affective pain descriptors . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
24,
35
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
120,
124
]
} |
the results of agarose gel electrophoresis of rna extracted by this procedure suggest that s. mansoni has an in vivo nick in the large rrna sub-unit . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
46,
49
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
135,
139
]
} |
the aim of the present study was to examine the fatty acid patterns of plasma phospholipids , cholesteryl esters , triglycerides and free fatty acids in patients with sjogren-larsson syndrome in order to detect whether absorption or metabolism is essential fatty acids may be abnormal . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
48,
58
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
133,
149
]
} |
medium chain length ( c8-c12 ) fatty acids were predominantly recovered in the free fatty acid fraction , whereas the remaining tri- and diglycerides became richer in long chain ( greater than or equal to c14 ) fatty acids suggesting a preferential lipolysis of medium chain fatty acid ester bonds . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
79,
94
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
211,
222
]
} |
epinephrine and norepinephrine levels increased significantly in stressed animals -- 22 pg/ml pre- to 1025 pg/ml postepinephrine , and 475 pg/ml pre- to 2292 pg/ml postnorepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
168,
182
]
} |
the partition of energy utilization was evaluated by 22 metabolic and nutritional balance studies in 13 formula-fed ( sma 20/24 ) , growing , appropriate-for-gestational age , very low-birth-weight infants ( mean +/- se birth weight , 1,155 +/- 39 gm ; study weight , 1,271 +/- 60 gm ; age at study , 21 +/- 2 days ; weight gain , 16.8 +/- 1 gm/kg/day ) . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
220,
232
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
317,
323
]
} |
in contrast to the lactate transport into the bbv , that into the blv : 1 ) was found to proceed only towards equilibrium , 2 ) showed na+ -independent coupling of the influx of l ( + ) lactate and the efflux of l ( + ) but not to the efflux of d ( - ) lactate , 3 ) was not inhibited by d ( - ) lactate , 2-thiolactate or 3-phenyl-lactate , but 4 ) was inhibited by 3-thiolactate and alpha-hydroxybutyrate and 5 ) was accelerated by changes in inwardly directed ionic gradients or by increases in cation conductance both of which led to increased intravesicular positivity . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
463,
468
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
498,
504
]
} |
early proximal flow rate ( vep ) , stop-flow pressure ( psf ) , early distal chloride concentration ( [ c ] ) , and flow rate were measured during perfusion of the loop of henle with mannitol solution ( 300 mosm kg-1 ) , 30mm nacl + mannitol ( 300 mosm kg-1 ) , 140 mm na isethionate and artificial tubular fluid . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
77,
85
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
226,
230
]
} |
it has been established that grave 's disease is an autoimmune condition characterized by immunization against tsh receptors . | NA | {
"id": "C0018213",
"name": "grave 's disease",
"pos": [
29,
45
]
} | {
"id": "C0004364",
"name": "autoimmune condition",
"pos": [
52,
72
]
} |
the unique cleavage of dna at the cos site by the terminase function of lambda was exploited to maintain the linkage between the vector and inserted gene sequences , a prerequisite for successful rescue of the transforming dna from high molecular weight dna of the eukaryotic transformant . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
254,
257
]
} |
transferring dna from electrophoretically resolved nucleosomes to diazobenzyloxymethyl cellulose : properties of nucleosomes along mouse satellite dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
13,
16
]
} | {
"id": "C0012934",
"name": "satellite",
"pos": [
137,
146
]
} |
specific interaction of one subunit of eukaryotic initiation factor eif-3 with 18s ribosomal rna within the binary complex , eif-3 small ribosomal subunit , as shown by cross-linking experiments . | NA | {
"id": "C1136317",
"name": "eukaryotic initiation factor",
"pos": [
39,
67
]
} | {
"id": "C0752615",
"name": "eif-3",
"pos": [
125,
130
]
} |
the positions of the 3'-ends of mature 26s rrna , pre-26s rrna and 35s pre-rrna were localized within this sequence by hybridization of the purified rna species to be selected dna fragments , followed by s1 nuclease treatment of the hybrid and a precise sizing of the rna-protected dna fragments on sequencing gels . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
176,
179
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
288,
289
]
} |
when present , it is transcribed into the mature 15s rrna to produce a longer variant of the rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
53,
57
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
93,
96
]
} |
bmv rna 4 , which has a sequence complementary to rrna , can form the initiation complex more easily than cmv rna5 . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
4,
7
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
50,
54
]
} |
the biosynthesis of the protein precursor of [ met ] enkephalin ( tyr-gly-gly-phe-met ) was studied using cell-free translation systems to characterize the enkephalin-precursor gene product and mrna . | NA | {
"id": "C0014295",
"name": "met ] enkephalin",
"pos": [
47,
63
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
156,
166
]
} |
gramicidin , a peptide antibiotic produced by bacillus brevis , inhibits initiation of transcription by rna polymerase ( nucleosidetriphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
104,
118
]
} | {
"id": "C0035673",
"name": "rna",
"pos": [
146,
149
]
} |
the monoclonal antibodies fell into at least four categories based on differences in crossreactivity with neuromuscular acetylcholinesterase of rabbit , dog , calf , and guinea pig , and competition tests indicated that the antibodies defined five different antigenic sites on the acetylcholinesterase molecule . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
224,
234
]
} |
one dependent on escherichia coli rna polymerase ( rna nucleotidyltransferase , ec 2.7.7.6 ) , and one dependent on general recombination . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
34,
48
]
} | {
"id": "C0035673",
"name": "rna",
"pos": [
51,
54
]
} |
two proteins , the 105-kilodalton subunit of the microvillus core and an approximately 30-kilodalton membrane protein , bind calmodulin in a calcium-independent manner . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
101,
117
]
} |
adrenal cells secrete steroids after stimulation with corticotropin ( acth ) , whereas cells reconstructed by fusing adrenal cell nuclei to fibroblast cytoplasms are temporarily ( 2-3 wk ) unresponsive to acth . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
8,
13
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
140,
150
]
} |
the first technique utilizes purified mitochondria , isolated from chloramphenicol ( cap ) -resistant fibroblasts , to confer cap resistance on an otherwise sensitive adrenal cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
175,
179
]
} |
treatment of peripheral blood mononuclear cells with pma increased cellular guanylate cyclase in most experiments , and dimethyl sulfoxide tended to inhibit this increase . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
13,
29
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
67,
75
]
} |
in contrast to previously characterized monoclonal antibodies that recognize the transferrin receptor , this antibody , designated 42/6 , blocks the binding of transferrin to its receptor and inhibits the growth of the human t leukemic cell line , ccrf-cem , in vitro . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
40,
61
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
109,
117
]
} |
the addition of iron to antibody-treated cultures in the form of ferric complexes or ferrous sulfate did not overcome the growth inhibitory effects of the anti-transferrin-receptor antibodies . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
16,
20
]
} | {
"id": "C0060282",
"name": "ferrous",
"pos": [
85,
92
]
} |
these data demonstrate that the antigenic determinant recognized by monoclonal antibody 9.2.27 is located on a glycoprotein-proteoglycan complex which may have unique implications for the interaction of glycoconjugates at the human melanoma tumor cell surface . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
111,
123
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
203,
218
]
} |
antibodies were raised in rabbits against epimastigote or trypomastigote proteins which had been immunoprecipitated with human antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
127,
135
]
} |
those viruses containing the ssh middle-sized rna segment efficiently infected the midgut and large amounts of viral antigen were detected in the midgut cells but antigen was detected in the secondary target organs only in 26 % ( 24/92 ) of the mosquitoes with midgut infection . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
111,
124
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
163,
170
]
} |
this paper describes the interaction of apamin , a bee venom neurotoxin , with the mouse neuroblastoma cell membrane . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
40,
46
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
51,
60
]
} |
guanylate cyclase immunofluorescence was abolished when the monoclonal antibodies were exposed to purified enzyme prior to incubation of the tissue slices or when control antibody was substituted for the primary antibody . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
60,
70
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
212,
220
]
} |
the uvra protein is a 115,000 molecular weight dna-binding protein having higher affinity for single-stranded than double-stranded dna . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
9,
16
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
47,
66
]
} |
on the other hand , the turn-on reaction of adipocyte adenylate cyclase , measured with the stable gtp analogue 5'-guanylyl imidodiphosphate ( 30 microm ) , was accelerated by isoproterenol ( 1 mm ) and nacl ( 100 mm ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
99,
102
]
} | {
"id": "C0018366",
"name": "guanylyl",
"pos": [
115,
123
]
} |
we conclude on the basis of these studies that ( i ) sequences from the right end of standard virus dna contain a recognition signal for the cleavage and packaging of concatemeric viral dna , ( ii ) the sequence-specific cleavage is either a prerequisite for or occurs during the entry of viral dna into capsid structures , and ( iii ) dna molecules significantly shorter than full-length standard viral dna can become encapsidated within nuclear capsids provided they contain the cleavage/packaging signal . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
336,
349
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
398,
407
]
} |
it is shown that the amino acid sequence and the dna gene sequence of the 25 amino-terminal residues of the lac repressor protein of escherichia coli are homologous with the sequences of five dna-binding proteins : the cro repressor proteins from phage lambda and phage 434 , the ci and cii proteins from phage lambda , and the repressor protein from salmonella phage p22 . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
192,
212
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
338,
345
]
} |
bradykinin and the angiotensin antagonist [ sar1 , ileu5 , ala8 ] aii had no significant effect on net na+ uptake . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
19,
30
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
66,
69
]
} |
in the presence of ouabain , 86rb+ uptake was not significantly affected by aii or aiii , indicating that angiotensin did not alter passive permeability to rb+ . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
76,
79
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
106,
117
]
} |
in the presence of ouabain , 86rb+ uptake was not significantly affected by aii or aiii , indicating that angiotensin did not alter passive permeability to rb+ . | NA | {
"id": "C0003012",
"name": "aiii",
"pos": [
83,
87
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
106,
117
]
} |
a member of the alu family , the dominant family of short interspersed repeated dna sequences in primates , interrupts a cloned repeat unit of african green monkey alpha-satellite dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
80,
83
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
182,
183
]
} |
the beta subunit of thyrotropin inhibits thyrotropin stimulation of both the adp-ribosylation and adenylate cyclase activities of the thyroid membrane . | NA | {
"id": "C0076641",
"name": "beta subunit",
"pos": [
4,
16
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
41,
52
]
} |
furthermore , with the possible exception of myosin heavy chain , the contractile protein genes expressed by cultured embryogenic muscle encode adult muscle proteins of both basal and slow fiber types , consistent with a co-activation-selective repression model of gene regulation during fiber type differentiation in developing skeletal muscle . | NA | {
"id": "C0009915",
"name": "contractile protein",
"pos": [
70,
89
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
150,
165
]
} |
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