may be inadequate for addressing the needs of the majority of those who have this disease. Lithium Lithium has been shown to decrease the phosphorylation of tau. Lithium treatment has been shown to reduce the density of neurofibrillary tangles in transgenic models in the hippocampus and spinal cord. Despite the decrease in density of NFTs, motor and memory deficits were not seen to improve following treatment. Additionally, no preventive effects have been seen in patients undergoing lithium treatment. Curcumin Curcumin (as Longvida) has been shown to reduce memory deficit and tau monomers in animal models, however no clinical trials have shown curcumin to remove tau from the brain. Other conditions Progressive supranuclear palsy although with straight filament rather than PHF tau Dementia pugilistica (chronic traumatic encephalopathy) Frontotemporal dementia and parkinsonism linked to chromosome 17 however without detectable β-amyloid plaques. Lytico-Bodig disease (Parkinson-dementia complex of Guam) Ganglioglioma and gangliocytoma Meningioangiomatosis Subacute sclerosing panencephalitis As well as lead encephalopathy, tuberous sclerosis, Pantothenate kinase-associated neurodegeneration, and lipofuscinosis See also Proteopathy References External links Pathologic page about Neurofibrillary tangles, by the University of Oklahoma. http://www.termedia.pl/magazine.php?magazine_id=20&article_id=5368&magazine_subpage=ABSTRACT https://web.archive.org/web/20051028184424/http://www.lifesci.sussex.ac.uk/home/Julian_Thorpe/ad_cyto.htm#tau It Takes Tau to Tangle : Plaques, Tangles and Neurodegenerative Disease (requires Flash video software) The Truth about Neurofibrillary Tangles (Flash video) Neurofibrillary Tangles - a definition (Flash video) Neurofibrillary Tangles in Alzheimer's Disease (Flash video) Alzheimer's disease Neuropathology