Spain, the Kingdom of Portugal, the Kingdom of Naples and the Kingdom of Sicily. The Sultan issued a formal invitation and refugees started arriving in the empire in great numbers. A key moment occurred in 1492, when more than 40,000 Spanish Jews fled the Spanish Inquisition. At that point in time, Constantinople's population was a mere 70,000 due to the various sieges of the city during the Crusades and the Black Death, so this historical event was also significant for repopulation of the city. These Sephardi Jews settled in Constantinople as well as Thessaloniki. The Jews satisfied various needs in the Ottoman Empire: the Muslim Turks were largely uninterested in business enterprises and accordingly left commercial occupations to members of minority religions. They also distrusted the Christian subjects whose countries had only recently been conquered by the Ottomans and therefore it was natural to prefer Jewish subjects to which this consideration did not apply. The Sephardi Jews were allowed to settle in the wealthier cities of the empire, especially in Rumelia (the European provinces, cities such as Constantinople, Sarajevo, Thessaloniki, Adrianople and Nicopolis), western and northern Anatolia (Bursa, Aydın, Tokat and Amasya), but also in the Mediterranean coastal regions (Jerusalem, Safed, Damascus, and Egypt). İzmir was not settled by Spanish Jews until later. The Jewish population in Jerusalem increased from 70 families in 1488 to 1500 at the beginning of the 16th century. That of Safed increased from 300 to 2000 families and almost surpassed Jerusalem in importance. Damascus had a Sephardic congregation of 500 families. Constantinople had a Jewish community of 30,000 individuals with 44 synagogues. Bayezid allowed the Jews to live on the banks of the Golden Horn. Egypt Eyalet, especially Cairo, received a large number of the exiles, who soon outnumbered Musta'arabi Jews. Gradually, the chief center of the Sephardi Jews became Thessaloniki, where the Spanish Jews soon outnumbered coreligionists of other nationalities and, at one time, the original native inhabitants. Although the status of the Jews in the Ottoman Empire may have often been exaggerated, it is undeniable that they enjoyed tolerance. Under the millet system they were organized as a community on the basis of religion alongside the other millets (e.g. Eastern Orthodox millet, Armenian Apostolic millet, etc.). In the framework of the millet, they had a considerable amount of administrative autonomy and were represented by the Hakham Bashi, the Chief Rabbi. There were no