liquid nitrogen to kill the Kothoga, as it is part-reptilian and likely cold-blooded. While collecting the remaining leaves in the lab, Margo and D'Agosta discover Frock has been killed. In the sewers, D'Agosta uses the leaves to lure the Kothoga away from the coal tunnel, allowing the guests to escape, though CPD officer Bailey and a guest are both killed. However, liquid nitrogen has no effect on the creature. Margo and D'Agosta flee. In the lab, her computer completes the analysis of the creature's human DNA, revealing John Whitney is the Kothoga, mutated after drinking the tribesmen's soup. The Kothoga smashes into the lab through the ceiling, while D'Agosta is locked outside. The creature chases Margo, corners her, and suddenly hesitates, seemingly recognizing her. Margo starts an explosive fire that incinerates the Kothoga, surviving by hiding inside a maceration tank. As dawn comes, D'Agosta and a team of police break into the lab, see the charred remains of the Kothoga, and rescue Margo from the tank. Cast Penelope Ann Miller as Margo Green, museum evolutionary biologist Tom Sizemore as Lieutenant Vincent D'Agosta, Chicago police detective Linda Hunt as Ann Cuthbert, museum curator James Whitmore as Albert Frock, museum scientist and Margo's mentor Clayton Rohner as Sergeant Hollingsworth, junior police detective and D'Agosta's subordinate Chi Muoi Lo as Greg Lee, an ambitious museum scientist trying to apply the same research grant away from Margo. Thomas Ryan as Tom Parkinson, the museum's head of security Robert Lesser as Mayor Robert Owen Diane Robin as Mrs. Owen, Mayor Owen's wife Lewis Van Bergen as John Whitney, museum anthropologist who went missing after his expedition in South America. John Whitney turns into a monster The Kothoga, ingesting the mushrooms. Francis X. McCarthy as George Blaisedale, a wealthy museum benefactor Constance Towers as Carrie Blaisedale, Mr. Blaisedale's wife Audra Lindley as Dr. Zwiezic, medical examiner John Kapelos as McNally, Chicago Police officer Tico Wells as Bailey, Chicago Police officer Mike Bacarella as Bradley, Chicago Police K-9 officer Gene Davis as Martini, crime scene investigator John DiSanti as Wootton, museum security guard David Proval as Johnson, museum security guard Jophery Brown as Frederick Ford, museum security guard Lyn Alicia Henderson as Perri Masai, restoration technician Don Harvey as Spota Production The Relic was based on the horror novel by Douglas Preston, an ex-journalist and former public relations director for the American Museum of Natural History in