High-fructose corn syrup (HFCS), also known as glucose–fructose, isoglucose and glucose–fructose syrup, is a sweetener made from corn starch. As in the production of conventional corn syrup, the starch is broken down into glucose by enzymes. To make HFCS, the corn syrup is further processed by D-xylose isomerase to convert some of its glucose into fructose. HFCS was first marketed in the early 1970s by the Clinton Corn Processing Company, together with the Japanese Agency of Industrial Science and Technology, where the enzyme was discovered in 1965. As a sweetener, HFCS is often compared to granulated sugar, but manufacturing advantages of HFCS over sugar include that it is easier to handle and cheaper. "HFCS 42" and "HFCS 55" refer to dry weight fructose compositions of 42% and 55% respectively, the rest being glucose. HFCS 42 is mainly used for processed foods and breakfast cereals, whereas HFCS 55 is used mostly for production of soft drinks. The United States Food and Drug Administration states that it is not aware of evidence showing that HFCS is less safe than traditional sweeteners such as sucrose and honey. Uses and exports of HFCS from American producers have grown steadily during the early 21st century. Food In the U.S., HFCS is among the sweeteners that mostly replaced sucrose (table sugar) in the food industry. Factors contributing to the rise of HFCS include production quotas of domestic sugar, import tariffs on foreign sugar, and subsidies of U.S. corn, raising the price of sucrose and lowering that of HFCS, making it cheapest for many sweetener applications. In spite of having a 10% greater fructose content, the relative sweetness of HFCS 55, used most commonly in soft drinks, is comparable to that of sucrose. HFCS (and/or standard corn syrup) is the primary ingredient in most brands of commercial "pancake syrup", as a less expensive substitute for maple syrup. Because of its similar sugar profile and lower price, HFCS is often added to adulterate honey. Assays to detect adulteration with HFCS use differential scanning calorimetry and other advanced testing methods. Production Process In the contemporary process, corn is milled to extract corn starch and an "acid-enzyme" process is used, in which the corn-starch solution is acidified to begin breaking up the existing carbohydrates. High-temperature enzymes are added to further metabolize the starch and convert the resulting sugars to fructose. The first enzyme added is alpha-amylase, which breaks the long