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In the cell nucleus, it seems that promoters are distributed preferentially at the edge of the chromosomal territories, likely for the co-expression of genes on different chromosomes. Furthermore, in humans, promoters show certain structural features characteristic for each chromosome. | 1 | Gene expression + Signal Transduction |
A deformation mechanism map is a way of representing the dominant deformation mechanism in a material loaded under a given set of conditions. The technique is applicable to all crystalline materials, metallurgical as well as geological. Additionally, work has been conducted regarding the use of deformation maps to nanostructured or very fine grain materials. Deformation mechanism maps usually consist of some kind of stress plotted against some kind of temperature axis, typically stress normalized using the shear modulus versus homologous temperature with contours of strain rate. The normalized shear stress is plotted on a log scale. While plots of normalized shear stress vs. homologous temperature are most common, other forms of deformation mechanism maps include shear strain rate vs. normalized shear stress and shear strain rate vs. homologous temperature. Thus deformation maps can be constructed using any two of stress (normalized), temperature (normalized), and strain rate, with contours of the third variable. A stress/strain rate plot is useful because power-law mechanisms then have contours of temperature which are straight lines.
For a given set of operating conditions, calculations are conducted and experiments performed to determine the predominant mechanism operative for a given material. Constitutive equations for the type of mechanism have been developed for each deformation mechanism and are used in the construction of the maps. The theoretical shear strength of the material is independent of temperature and located along the top of the map, with the regimes of plastic deformation mechanisms below it. Constant strain rate contours can be constructed on the maps using the constitutive equations of the deformation mechanisms which makes the maps extremely useful. | 0 | Metallurgy |
The difference between pitting and micropitting is the size of the pits after surface fatigue. Pits formed by micropitting are approximately 10–20 μm in depth, and micropitted metal often has a frosted or gray appearance. Normal pitting creates larger and more visible pits. Micropits are originated from the local contact of asperities produced by improper lubrication. | 0 | Metallurgy |
Detonation sprayed coatings are primarily mechanically bonded. This means that the surface of the component being sprayed, must be properly prepared so as to maximise the bond strength between the sprayed coating and the substrate. To successfully prepare the surface it must be cleaned of all greases, oils, dirt and other contaminants and sufficiently roughened to provide enough of a surface irregularity for the coating to cling to. Chemical processes are generally the most suitable methods used to clean the substrate surface. After which care must be taken not to touch and/or dirty the surface prior to spraying. The three methods used to roughen up the substrate surface are abrasive blasting, machining and bond coating. Cleaning occurs only after the roughening of the surface except for when a bond coating is used; the surface must be cleaned before and possibly after this process too. Application of the detonation spray coating should be performed as soon as possible after a substrates surface has been prepared. | 0 | Metallurgy |
An inverse agonist can have effects similar to those of an antagonist, but causes a distinct set of downstream biological responses. Constitutively active receptors that exhibit intrinsic or basal activity can have inverse agonists, which not only block the effects of binding agonists like a classical antagonist but also inhibit the basal activity of the receptor. Many drugs previously classified as antagonists are now beginning to be reclassified as inverse agonists because of the discovery of constitutive active receptors. Antihistamines, originally classified as antagonists of histamine H receptors have been reclassified as inverse agonists. | 1 | Gene expression + Signal Transduction |
As DNA printing and DNA assembly methods have allowed commercial gene synthesis to become progressively and exponentially cheaper over the past years, artificial gene synthesis represents a powerful and flexible engineering tool for creating and designing new DNA sequences and protein functions. Besides synthetic biology, various research areas like those involving heterologous gene expression, vaccine development, gene therapy and molecular engineering, would benefit greatly from having fast and cheap methods to synthesise DNA to code for proteins and peptides. The methods used for DNA printing and assembly have even enabled the use of DNA as an information storage medium. | 1 | Gene expression + Signal Transduction |
Lilleby smelteverk was a smeltmill located in Lilleby, Trondheim, Sør-Trøndelag county, Norway, next to City Lade. It is well known for having produced the world's cleanest ferrosilicon (an alloy that contains iron and silicon) for NASA. Shut down in December 20th, 2002, the production moved to Mo I Rana.
The building is demolished. | 0 | Metallurgy |
Also located on museum grounds is the Short Track Model Railroad Club, featuring an NTrak model railroad with trains traveling through more than 40 modules, including a drive-in movie theater, a fairgrounds, farms, towns, and a coal mine and other scenes.
The Short Track, N-Scale, Model Railroad club is an educational organization that seeks to further the appreciation of railroad history in the United States. Many members are also National Model Railroad Association (NMRA) members and a few have earned the title of "Master Modeler." Their Donner Pass, N-scale, model railroad exhibit shows the Southern Pacific crossing of the Sierra Mountains between Colfax, CA and West Reno, NV.
There is also a small layout that can be operated by children (The Young & Victorious RR). | 0 | Metallurgy |
The general reaction that occurs in the Pidgeon process is:
For industrial use, ferrosilicon is used because its cheaper and more readily available than silicon. The iron from the alloy is a spectator in the reaction. CaC may also be used as an even cheaper alternative for silicon and ferrosilicon, but is disadvantageous because it decreases the magnesium yield slightly.
The magnesium raw material of this type of reaction is magnesium oxide, which is obtained in many ways. In all cases, the raw materials have to be calcined to remove both water and carbon dioxide. Without doing so, the reaction would be gaseous at reaction temperatures and may even revert the reaction. Magnesium oxide can be obtained by sea or lake water magnesium chloride hydrolyzed to hydroxide. It is calcined to magnesium oxide by removing water. Another option is to use mined magnesite (MgCO) calcined to magnesium oxide by carbon dioxide removal.
The most used raw material is mined dolomite, a mixed (Ca,Mg)CO, where the calcium oxide present in the reaction zone scavenges the silica formed, releasing heat and consuming one of the products, ultimately helping push the equilibrium to the right.
(1) Dolomite calcination
(2) Reduction
The Pidgeon process is an endothermic reaction (H° ~183.0kJ/mol Si). Thermodynamically speaking, the temperatures decrease when the vacuum is used for both MgO and calcined dolomite. | 0 | Metallurgy |
sAC activation by bicarbonate is necessary for motility and other aspects of capacitation in the spermatozoa of mammals. In human males, mutations in the ADCY10 gene that lead to the inactivation of sAC have been linked to cases of sterility. Due to this essential role in male fertility, sAC has been explored as a potential target for non-hormonal male contraception. | 1 | Gene expression + Signal Transduction |
Arsenical bronze was used by many societies and cultures across the globe. Firstly, the Iranian plateau, followed by the adjacent Mesopotamian area, together covering modern Iran, Iraq and Syria, has the earliest arsenical bronze metallurgy in the world, as previously mentioned. It was in use from the 4th millennium BC through to mid 2nd millennium BC, a period of nearly 2,000 years. There was a great deal of variation in arsenic content of artefacts throughout this period, making it impossible to say exactly how much was added deliberately and how much came about by accident.
These matters were clarified considerably by 2016. The two relevant ancient sites in eastern Turkey (Malatya Province) are Norşuntepe and Değirmentepe, where arsenical bronze production was taking place before 4000 BC. Hearths or natural draft furnaces, slag, ore, and pigment had been recovered throughout these sites. This was in the context of architectural complexes typical of southern Mesopotamian architecture.
According to Boscher (2016), at Değirmentepe, arsenical copper objects were clearly manufactured around 4200 BC, yet the technological aspects of this production remain unclear. This is because the primary smelting of ore seems to have been undertaken elsewhere, perhaps already at the sites of mining.
In contrast, the related Norşuntepe site provides a better context of production, and demonstrates that some form of arsenic alloying was indeed taking place by the 4th millennium BC. Since the slag identified at Norşuntepe contains no arsenic, this means that arsenic in some form was added separately.
Societies using arsenical bronze include the Akkadians, those of Ur, and the Amorites, all based around the Tigris and Euphrates rivers and centres of the trade networks which spread arsenical bronze across the Middle East during the Bronze Age.
The Chalcolithic-period Nahal Mishmar hoard in the Judean Desert west of the Dead Sea contains a number of arsenical bronze (4–12% arsenic) and perhaps arsenical copper artifacts made using the lost-wax process, the earliest known use of this complex technique. "Carbon-14 dating of the reed mat in which the objects were wrapped suggests that it dates to at least 3500 B.C. It was in this period that the use of copper became widespread throughout the Levant, attesting to considerable technological developments that parallel major social advances in the region."
In ancient Egypt, use of arsenical bronze/copper is confirmed since the second phase of Naqada culture, and then used widely until the beginning of the New Kingdom, i.e. in the Egyptian Chalcolithic, Early and Middle Bronze Age, and within the same eras also in ancient Nubia. In the Old Kingdom, era of the largest pyramids builders, the arsenical copper was used for the production of tools at Giza. Arsenical copper was also processed in the workshop uncovered at Gizas Heit el-Ghurab, "lost city of pyramid builders" from the reign of Menkaure. Egyptian and Nubian objects made of arsenical copper were identified in the collections in Brussels, and in Leipzig. In the Middle Kingdom, use of tin bronze is increasing in ancient Egypt and Nubia. One of the largest studies of such material was the research of the Egyptian and Nubian axe blades in the British Museum, and it provided comparable results. Similar situation can be observed in Middle Bronze Age Kerma.
Sulfide deposits frequently are a mix of different metal sulfides, such as copper, zinc, silver, arsenic, mercury, iron and other metals. (Sphalerite (ZnS with more or less iron), for example, is not uncommon in copper sulfide deposits, and the metal smelted would be brass, which is both harder and more durable than copper.) The metals could theoretically be separated out, but the alloys resulting were typically much stronger than the metals individually.
The use of arsenical bronze spread along trade routes into northwestern China, to the Gansu–Qinghai region, with the Siba, Qijia and Tianshanbeilu cultures. However it is still unclear as to whether arsenical bronze artefacts were imported or made locally, although the latter is suspected as being more likely due to possible local exploitation of mineral resources. On the other hand, the artefacts show typological connections to the Eurasian steppe.
The Eneolithic period in Northern Italy, with the Remedello and Rinaldone cultures in 2800 to 2200 BC, saw the use of arsenical bronze. Indeed, it seems that arsenical bronze was the most common alloy in use in the Mediterranean basin at this time.
In South America, arsenical bronze was the predominant alloy in Ecuador and north and central Peru, because of the rich arsenic bearing ores present there. By contrast, the south and central Andes, southern Peru, Bolivia and parts of Argentina, were rich in the tin ore cassiterite and thus did not use arsenical bronze.
The Sican Culture of northwestern coastal Peru is famous for its use of arsenical bronze during the period 900 to 1350 AD. Arsenical bronze co-existed with tin bronze in the Andes, probably due to its greater ductility which meant it could be easily hammered into thin sheets which were valued in local society. | 0 | Metallurgy |
Proteins without signal peptides can also be secreted by unconventional mechanisms. E.g. Interleukin, Galectin. The process by which such secretory proteins gain access to the cell exterior is termed unconventional protein secretion (UPS). In plants, even 50% of secreted proteins can be UPS dependent. | 1 | Gene expression + Signal Transduction |
In eukaryote cells, RNA polymerase III (also called Pol III) is a protein that transcribes DNA to synthesize 5S ribosomal RNA, tRNA, and other small RNAs.
The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions. Therefore, the regulation of Pol III transcription is primarily tied to the regulation of cell growth and the cell cycle and thus requires fewer regulatory proteins than RNA polymerase II. Under stress conditions, however, the protein Maf1 represses Pol III activity. Rapamycin is another Pol III inhibitor via its direct target TOR. | 1 | Gene expression + Signal Transduction |
Proteins are classified into the chemokine family based on their structural characteristics, not just their ability to attract cells. All chemokines are small, with a molecular mass of between 8 and 10 kDa. They are approximately 20-50% identical to each other; that is, they share gene sequence and amino acid sequence homology. They all also possess conserved amino acids that are important for creating their 3-dimensional or tertiary structure, such as (in most cases) four cysteines that interact with each other in pairs to create a Greek key shape that is a characteristic of chemokines. Intramolecular disulfide bonds typically join the first to third, and the second to fourth cysteine residues, numbered as they appear in the protein sequence of the chemokine. Typical chemokine proteins are produced as pro-peptides, beginning with a signal peptide of approximately 20 amino acids that gets cleaved from the active (mature) portion of the molecule during the process of its secretion from the cell. The first two cysteines, in a chemokine, are situated close together near the N-terminal end of the mature protein, with the third cysteine residing in the centre of the molecule and the fourth close to the C-terminal end. A loop of approximately ten amino acids follows the first two cysteines and is known as the N-loop. This is followed by a single-turn helix, called a 3-helix, three β-strands and a C-terminal α-helix. These helices and strands are connected by turns called 30s, 40s and 50s loops; the third and fourth cysteines are located in the 30s and 50s loops. | 1 | Gene expression + Signal Transduction |
There are several consequences the formation of a transcription factory has on nuclear and genomic structures. It has been proposed that the factories are responsible for nuclear organisation; they have been suggested to promote chromatin loop formation by two potential mechanisms:
The first mechanism suggests that loops form because 2 genes on the same chromosome require the same transcription machinery that would be found in a specific transcription factory. This requirement will attract the gene loci to the factory thus creating a loop.
Transcription factories are also suggested to be responsible for gene clustering, this is because related genes would require the same transcriptional machinery and if a factory satisfies these needs the genes would be attracted to the factory
. While the clustering of genes can be beneficial for transcriptional efficiency, there could be negative consequences to this. Gene translocation events occur when genes are in close proximity to one another; which will occur more often when a transcriptional factory is present. Gene translocation events, like point mutations, generally are detrimental to the organism and so therefore could lead to the possibility of disease. However, on the other hand recent research has suggested that there is no correlation between inter-gene interactions and translocation frequencies. | 1 | Gene expression + Signal Transduction |
Demasking is the process of clearing the part of etchant and maskant. Etchant is generally removed with a wash of clear, cold water. A de-oxidizing bath may also be required in the common case that the etching process left a film of oxide on the surface of the material. Various methods may be used to remove the maskant, the most common being hand removal using scraping tools. This is frequently time-consuming and laborious, and for large-scale processes may be automated. | 0 | Metallurgy |
Sinker EDM, also called ram EDM, cavity type EDM or volume EDM, consists of an electrode and workpiece submerged in an insulating liquid such as, more typically, oil or, less frequently, other dielectric fluids. The electrode and workpiece are connected to a suitable power supply. The power supply generates an electrical potential between the two parts. As the electrode approaches the workpiece, dielectric breakdown occurs in the fluid, forming a plasma channel, and a small spark jumps.
These sparks usually strike one at a time, because it is very unlikely that different locations in the inter-electrode space have the identical local electrical characteristics which would enable a spark to occur simultaneously in all such locations. These sparks happen in huge numbers at seemingly random locations between the electrode and the workpiece. As the base metal is eroded, and the spark gap subsequently increased, the electrode is lowered automatically by the machine so that the process can continue uninterrupted. Several hundred thousand sparks occur per second, with the actual duty cycle carefully controlled by the setup parameters. These controlling cycles are sometimes known as "on time" and "off time", which are more formally defined in the literature.
The on time setting determines the length or duration of the spark. Hence, a longer on time produces a deeper cavity from each spark, creating a rougher finish on the workpiece. The reverse is true for a shorter on time. Off time is the period of time between sparks. Although not directly affecting the machining of the part, the off time allows the flushing of dielectric fluid through a nozzle to clean out the eroded debris. Insufficient debris removal can cause repeated strikes in the same location which can lead to a short circuit. Modern controllers monitor the characteristics of the arcs and can alter parameters in microseconds to compensate. The typical part geometry is a complex 3D shape, often with small or odd shaped angles. Vertical, orbital, vectorial, directional, helical, conical, rotational, spin, and indexing machining cycles are also used. | 0 | Metallurgy |
Access to nucleosomal DNA is governed by two major classes of protein complexes:
# Covalent histone-modifying complexes.
# ATP-dependent chromatin remodeling complexes. | 1 | Gene expression + Signal Transduction |
When the B cells get activated, class switching can occur. The class switching involves switch regions that made up of multiple copies of short repeats (GAGCT and TGGGG). These switches occur at the level of rearrangements of the DNA because there is a looping event that chops off the constant regions for IgM and IgD and form the IgG mRNAs. Any continuous looping occurrence will produce IgE or IgA mRNAs. In addition, cytokines are factors that have great effects on class switching of different classes of antibodies. Their interaction with B cells provides the appropriates signals needed for B cells differentiation and eventual class switching occurrence. For example, interleukin-4 induces the rearrangements of heavy chain immunoglobulin genes. That is IL- 4 induces the switching of Cμ to Cγ to Cκ | 1 | Gene expression + Signal Transduction |
At one level, biological cells can be thought of as "partially mixed bags" of biological chemicals – in the discussion of gene regulatory networks, these chemicals are mostly the messenger RNAs (mRNAs) and proteins that arise from gene expression. These mRNA and proteins interact with each other with various degrees of specificity. Some diffuse around the cell. Others are bound to cell membranes, interacting with molecules in the environment. Still others pass through cell membranes and mediate long range signals to other cells in a multi-cellular organism. These molecules and their interactions comprise a gene regulatory network. A typical gene regulatory network looks something like this:
The nodes of this network can represent genes, proteins, mRNAs, protein/protein complexes or cellular processes. Nodes that are depicted as lying along vertical lines are associated with the cell/environment interfaces, while the others are free-floating and can diffuse. Edges between nodes represent interactions between the nodes, that can correspond to individual molecular reactions between DNA, mRNA, miRNA, proteins or molecular processes through which the products of one gene affect those of another, though the lack of experimentally obtained information often implies that some reactions are not modeled at such a fine level of detail. These interactions can be inductive (usually represented by arrowheads or the + sign), with an increase in the concentration of one leading to an increase in the other, inhibitory (represented with filled circles, blunt arrows or the minus sign), with an increase in one leading to a decrease in the other, or dual, when depending on the circumstances the regulator can activate or inhibit the target node. The nodes can regulate themselves directly or indirectly, creating feedback loops, which form cyclic chains of dependencies in the topological network. The network structure is an abstraction of the system's molecular or chemical dynamics, describing the manifold ways in which one substance affects all the others to which it is connected. In practice, such GRNs are inferred from the biological literature on a given system and represent a distillation of the collective knowledge about a set of related biochemical reactions. To speed up the manual curation of GRNs, some recent efforts try to use text mining, curated databases, network inference from massive data, model checking and other information extraction technologies for this purpose.
Genes can be viewed as nodes in the network, with input being proteins such as transcription factors, and outputs being the level of gene expression. The value of the node depends on a function which depends on the value of its regulators in previous time steps (in the Boolean network described below these are Boolean functions, typically AND, OR, and NOT). These functions have been interpreted as performing a kind of information processing within the cell, which determines cellular behavior. The basic drivers within cells are concentrations of some proteins, which determine both spatial (location within the cell or tissue) and temporal (cell cycle or developmental stage) coordinates of the cell, as a kind of "cellular memory". The gene networks are only beginning to be understood, and it is a next step for biology to attempt to deduce the functions for each gene "node", to help understand the behavior of the system in increasing levels of complexity, from gene to signaling pathway, cell or tissue level.
Mathematical models of GRNs have been developed to capture the behavior of the system being modeled, and in some cases generate predictions corresponding with experimental observations. In some other cases, models have proven to make accurate novel predictions, which can be tested experimentally, thus suggesting new approaches to explore in an experiment that sometimes wouldn't be considered in the design of the protocol of an experimental laboratory. Modeling techniques include differential equations (ODEs), Boolean networks, Petri nets, Bayesian networks, graphical Gaussian network models, Stochastic, and Process Calculi. Conversely, techniques have been proposed for generating models of GRNs that best explain a set of time series observations. Recently it has been shown that ChIP-seq signal of histone modification are more correlated with transcription factor motifs at promoters in comparison to RNA level. Hence it is proposed that time-series histone modification ChIP-seq could provide more reliable inference of gene-regulatory networks in comparison to methods based on expression levels. | 1 | Gene expression + Signal Transduction |
Metallurgical failure analysis is the process to determine the mechanism that has caused a metal component to fail. It can identify the cause of failure, providing insight into the root cause and potential solutions to prevent similar failures in the future, as well as culpability, which is important in legal cases. Resolving the source of metallurgical failures can be of financial interest to companies. The annual cost of corrosion (a common cause of metallurgical failures) in the United States was estimated by NACE International in 2012 to be $450 billion a year, a 67% increase compared to estimates for 2001. These failures can be analyzed to determine their root cause, which if corrected, would save reduce the cost of failures to companies.
Failure can be broadly divided into functional failure and expected performance failure. Functional failure occurs when a component or process fails and its entire parent system stops functioning entirely. This category includes the common idea of a component fracturing rapidly. Expected performance failures are when a component causes the system to perform below a certain performance criterion, such as life expectancy, operating limits, or shape and color. Some performance criteria are documented by the supplier, such as maximum load allowed on a tractor, while others are implied or expected by the customer, such gas consumption (miles per gallon for automobiles).
Often a combination of both environmental conditions and stress will cause failure. Metal components are designed to withstand the environment and stresses that they will be subjected to. The design of a metal component involves not only a specific elemental composition but also specific manufacturing process such as heat treatments, machining processes, etc. The huge arrays of different metals that result all have unique physical properties. Specific properties are designed into metal components to make them more robust to various environmental conditions. These differences in physical properties will exhibit unique failure modes. A metallurgical failure analysis takes into account as much of this information as possible during analysis. The ultimate goal of failure analysis is to provide a determination of the root cause and a solution to any underlying problems to prevent future failures. | 0 | Metallurgy |
The Roman Bun Ingots are less pure than the earlier LBA examples and Tylecote suggests that they may be a direct product of smelting. Theoretically such an ingot could be formed in the base of the furnace. However, this is problematic in the case of the stamped examples as this would require the furnace to be dismantled or else have a short shaft to allow access for stamping. As a solution the furnace could have been tapped into a mould at the completion of smelting. It is possible that both methods were used as several of the ingots seem to have had additional metal poured onto the top in order to allow stamping. | 0 | Metallurgy |
Red mud is the waste product that is produced in the digestion of bauxite with sodium hydroxide. It has high calcium and sodium hydroxide content with a complex chemical composition, and accordingly is very caustic and a potential source of pollution. The amount of red mud produced is considerable, and this has led scientists and refiners to seek uses for it. It has received attention as a possible source of vanadium. Due to the low extraction yield much of the gallium ends up in the aluminium oxide as an impurity and in the red mud.
One use of red mud is in ceramic production. Red mud dries into a fine powder that contains iron, aluminium, calcium and sodium. It becomes a health risk when some plants use the waste to produce aluminium oxides.
In the United States, the waste is disposed in large impoundments, a sort of reservoir created by a dam. The impoundments are typically lined with clay or synthetic liners. The US does not approve of the use of the waste due to the danger it poses to the environment. The EPA identified high levels of arsenic and chromium in some red mud samples. | 0 | Metallurgy |
The borax method is a technique of artisanal gold mining, which uses borax as a flux to purify gold concentrates. By using borax, no mercury flour is produced, hence gold recovery increases. | 0 | Metallurgy |
Both p90 and p70 Rsk phosphorylate ribosomal protein s6, part of the translational machinery, but several other substrates have been identified, including other ribosomal proteins. Cytosolic substrates of p90 include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule; Son of Sevenless, the Ras exchange factor; and Myt1, an inhibitor of cdc2.
RSK phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This interaction of phospho SOS1 and 14-3-3 negatively regulates Ras-MAPK pathway.
p90 also regulates transcription factors including cAMP response element-binding protein (CREB); estrogen receptor-α (ERα); IκBα/NF-κB; and c-Fos. | 1 | Gene expression + Signal Transduction |
It has also been discovered that GLD2 has medical uses.
For example, such enzyme is overexpressed in patients who suffer from cancer; that's why it can be used as a prognostic factor for early appearance in breast cancer patients. Moreover, PAP activity is used to measure the effect of anticancer drugs as etoposide and cordycepin in two carcinoma cell lines: HeLa, which is the human epithelioid cervix carcinoma, and MCF-7 (human breast cancer).
However, in spite its utilities it can also be involved in the expression of several common diseases such as: leukemia, liver cirrhosis, brain injuries, hepatitis and in some cases infertility in male patients. | 1 | Gene expression + Signal Transduction |
Due to its regulatory role in the cell cycle, targeting the DREAM complex might enhance anticancer treatments such as imatinib. | 1 | Gene expression + Signal Transduction |
The kinesis strategy controlled by the locally and instantly evaluated well-being (fitness) can be described in simple words: Animals stay longer in good conditions and leave bad conditions more quickly. If the well-being is measured by the local reproduction coefficient then the minimal reaction-diffusion model of kinesis can be written as follows:
For each population in the biological community,
where:
is the population density of ith species,
represents the abiotic characteristics of the living conditions (can be multidimensional),
is the reproduction coefficient, which depends on all and on s,
is the equilibrium diffusion coefficient (defined for equilibrium ). The coefficient characterises dependence of the diffusion coefficient on the reproduction coefficient.
The models of kinesis were tested with typical situations. It was demonstrated that kinesis is beneficial for assimilation of both patches and fluctuations of food distribution. Kinesis may delay invasion and spreading of species with the Allee effect. | 1 | Gene expression + Signal Transduction |
Operons occur primarily in prokaryotes but also rarely in some eukaryotes, including nematodes such as C. elegans and the fruit fly, Drosophila melanogaster. rRNA genes often exist in operons that have been found in a range of eukaryotes including chordates. An operon is made up of several structural genes arranged under a common promoter and regulated by a common operator. It is defined as a set of adjacent structural genes, plus the adjacent regulatory signals that affect transcription of the structural genes. The regulators of a given operon, including repressors, corepressors, and activators, are not necessarily coded for by that operon. The location and condition of the regulators, promoter, operator and structural DNA sequences can determine the effects of common mutations.
Operons are related to regulons, stimulons and modulons; whereas operons contain a set of genes regulated by the same operator, regulons contain a set of genes under regulation by a single regulatory protein, and stimulons contain a set of genes under regulation by a single cell stimulus. According to its authors, the term "operon" is derived from the verb "to operate". | 1 | Gene expression + Signal Transduction |
A bloomery is a type of metallurgical furnace once used widely for smelting iron from its oxides. The bloomery was the earliest form of smelter capable of smelting iron. Bloomeries produce a porous mass of iron and slag called a bloom. The mix of slag and iron in the bloom, termed sponge iron, is usually consolidated and further forged into wrought iron. Blast furnaces, which produce pig iron, have largely superseded bloomeries. | 0 | Metallurgy |
The sigma-2 receptor takes part in a number of normal-function roles, including cell proliferation, autophagy, cholesterol homeostasis, and both non-neuronal and neuronal signaling. Much of sigma-2 receptor function relies on signaling cascades. The receptor's interaction with EGFR and PGRMC1 proteins allow for sigma-2 receptors to play diverse roles within cell through Ras, PLC, and PI3K signaling. | 1 | Gene expression + Signal Transduction |
Historians debate whether bloomery-based ironworking ever spread to China from the Middle East. One theory suggests that metallurgy was introduced through Central Asia. In 2008, two iron fragments were excavated at the Mogou site, in Gansu. They have been dated to the 14th century BC, belonging to the period of Siwa culture, suggesting an independent Chinese origin. One of the fragments was made of bloomery iron rather than meteoritic iron.
The earliest iron artifacts made from bloomeries in China date to end of the 9th century BC. Cast iron was used in ancient China for warfare, agriculture and architecture. Around 500 BC, metalworkers in the southern state of Wu achieved a temperature of 1130 °C. At this temperature, iron combines with 4.3% carbon and melts. The liquid iron can be cast into molds, a method far less laborious than individually forging each piece of iron from a bloom.
Cast iron is rather brittle and unsuitable for striking implements. It can be decarburized to steel or wrought iron by heating it in air for several days. In China, these iron working methods spread northward, and by 300 BC, iron was the material of choice throughout China for most tools and weapons. A mass grave in Hebei province, dated to the early 3rd century BC, contains several soldiers buried with their weapons and other equipment. The artifacts recovered from this grave are variously made of wrought iron, cast iron, malleabilized cast iron, and quench-hardened steel, with only a few, probably ornamental, bronze weapons.
During the Han Dynasty (202 BC–220 AD), the government established ironworking as a state monopoly, repealed during the latter half of the dynasty and returned to private entrepreneurship, and built a series of large blast furnaces in Henan province, each capable of producing several tons of iron per day. By this time, Chinese metallurgists had discovered how to fine molten pig iron, stirring it in the open air until it lost its carbon and could be hammered (wrought). In modern Mandarin-Chinese, this process is now called chao, literally stir frying. Pig iron is known as raw iron, while wrought iron is known as cooked iron. By the 1st century BC, Chinese metallurgists had found that wrought iron and cast iron could be melted together to yield an alloy of intermediate carbon content, that is, steel.
According to legend, the sword of Liu Bang, the first Han emperor, was made in this fashion. Some texts of the era mention "harmonizing the hard and the soft" in the context of ironworking; the phrase may refer to this process. The ancient city of Wan (Nanyang) from the Han period forward was a major center of the iron and steel industry. Along with their original methods of forging steel, the Chinese had also adopted the production methods of creating Wootz steel, an idea imported from India to China by the 5th century AD.
During the Han Dynasty, the Chinese were also the first to apply hydraulic power (i.e. a waterwheel) in working the bellows of the blast furnace. This was recorded in the year 31 AD, as an innovation by the Chinese mechanical engineer and politician Du Shi, Prefect of Nanyang. Although Du Shi was the first to apply water power to bellows in metallurgy, the first drawn and printed illustration of its operation with water power appeared in 1313 AD, in the Yuan Dynasty era text called the Nong Shu.
In the 11th century, there is evidence of the production of steel in Song China using two techniques: a "berganesque" method that produced inferior, heterogeneous steel and a precursor to the modern Bessemer process that utilized partial decarbonization via repeated forging under a cold blast. By the 11th century, there was a large amount of deforestation in China due to the iron industry's demands for charcoal. By this time however, the Chinese had learned to use bituminous coke to replace charcoal, and with this switch in resources many acres of prime timberland in China were spared. | 0 | Metallurgy |
Some capillary techniques provide also a chamber like arrangement, however, there is no filter between the cells and the test substance. Quantitative results are gained by the multiwell type of this probe using 4-8-12-channel pipettes. Accuracy of the pipette and increased number of the parallel running samples is the great advantage of this test.
Counting of cells: positive responder cells are count from the lower chamber (long incubation time) or from the filter (short incubation time). For detection of cells general staining techniques (e.g. trypan blue) or special probes (e.g. mt-dehydrogenase detection with MTT assay) are used. Labelled (e.g. fluorochromes) cells are also used, in some assays cells get labelled during transmigration the filter. | 1 | Gene expression + Signal Transduction |
Aside from use as decorative or utilitarian objects, gold was used throughout the Philippine archipelago as currency, whether in the form of gold dust, small beads, or barter rings. | 0 | Metallurgy |
The Association for Materials Protection and Performance (AMPP), is a professional association focused on the protection of assets and performance of materials. AMPP was created when NACE International and SSPC the Society for Protective Coatings merged in 2021. AMPP is active in more than 130 countries and has more than 40,000 members. AMPP is headquartered in the U.S. with offices in Houston, Texas and Pittsburgh, Pennsylvania. Additional offices are located in the U.K., China, Malaysia, Brazil, and Saudi Arabia with a training center in Dubai. | 0 | Metallurgy |
Although ectopic expression can be caused by a natural condition, it is uncommonly seen in nature because it is a product of defects in gene regulation. In fact, ectopic expression is more commonly used for research purposes. Artificially induced gene expression helps to determine the function of a gene of interest. Common techniques such as overexpressing or misexpressing the genes by UAS-[http://flystocks.bio.indiana.edu/Browse/uas/uashome.htm Gal4] system in D. melanogaster are used. In model organisms, such techniques are used to perform genetic screens to identify a function of the gene involved in specific cellular or developmental processes.
Ectopic expression using these techniques is a useful tool because phenotypes induced in a tissue or cell type where are not normally expressed are easily distinguishable compared to a tissue or cell type where the gene is normally expressed. By the comparison with its basal expression, the function of a gene of interest can be identified.
Although the understanding of ectopic expressions deals with endogenous genes in an organism, it can be expended to a similar concept like transgenesis, which an exogenous gene is introduced to a cell or tissue type in which the gene is not usually expressed. Practices of ectopic expression in biological science is not only limited to identifying a function of the gene in a known cell or tissue type but also implemented to discover unknown or additional functions of the gene by ectopic expression. | 1 | Gene expression + Signal Transduction |
The simplest forge, known as the Corsican, was used prior to the advent of Christianity. Examples of improved bloomeries are the Stuckofen, sometimes called wolf-furnace,) which remained until the beginning of the 19th century. Instead of using natural draught, air was pumped in by a trompe, resulting in better quality iron and an increased capacity. This pumping of air in with bellows is known as cold blast, and it increases the fuel efficiency of the bloomery and improves yield. They can also be built bigger than natural draught bloomeries. | 0 | Metallurgy |
The pre-mRNA of this protein is subject to A to I RNA editing, which is catalyzed by a family of adenosine deaminases acting on RNA (ADARs) that specifically recognize adenosines within double-stranded regions of pre-mRNAs and deaminate them to inosine. Inosines are recognised as guanosine by the cell's translational machinery. There are three members of the ADAR family: ADARs 1-3, with ADAR 1 and ADAR 2 being the only enzymatically active members. ADAR 3 is thought to have a regulatory role in the brain. ADAR 1 and ADAR 2 are widely expressed in tissues while ADAR 3 is restricted to the brain. The double-stranded regions of RNA are formed by base-pairing between residues in a region complementary to the region of the editing site. This complementary region is usually found in a neighbouring intron but can also be located in an exonic sequence. The region that pairs with the editing region is known as an Editing Complementary Sequence (ECS). | 1 | Gene expression + Signal Transduction |
When a molten metal is mixed with another substance, there are two mechanisms that can cause an alloy to form, called atom exchange and the interstitial mechanism. The relative size of each element in the mix plays a primary role in determining which mechanism will occur. When the atoms are relatively similar in size, the atom exchange method usually happens, where some of the atoms composing the metallic crystals are substituted with atoms of the other constituent. This is called a substitutional alloy. Examples of substitutional alloys include bronze and brass, in which some of the copper atoms are substituted with either tin or zinc atoms respectively.
In the case of the interstitial mechanism, one atom is usually much smaller than the other and can not successfully substitute for the other type of atom in the crystals of the base metal. Instead, the smaller atoms become trapped in the interstitial sites between the atoms of the crystal matrix. This is referred to as an interstitial alloy. Steel is an example of an interstitial alloy, because the very small carbon atoms fit into interstices of the iron matrix.
Stainless steel is an example of a combination of interstitial and substitutional alloys, because the carbon atoms fit into the interstices, but some of the iron atoms are substituted by nickel and chromium atoms. | 0 | Metallurgy |
Ceramic anode materials include Ni-Fe, Sn, and Ni-Li based oxides. These anodes show promise as they are extremely stable during the reduction process at normal operating temperatures (~1000 °C), ensuring that the Al is not contaminated. The stability of these anodes also allows them to be used with a range of electrolytes. However, ceramic anodes suffer from poor electrical conductivity and low mechanical strength.
Alternatively metal anodes boast high mechanical strength and conductivity but tend to corrode easily during the reduction process. Some material systems that are used in inert metal anodes include Al-Cu, Ni-Cu, and Fe-Ni-Cu systems. Additional additives such as Sn, Ag, V, Nb, Ir, Ru can be included in these systems to form non reactive oxides on the anode surface, but this significantly increases the cost and embodied energy of the anode.
Cermet anodes are the combination of a metal and ceramic anode, and aim to take advantage of the desirable properties of both; the electrical cpnductivity and toughness of the metal and stability of the ceramic. These anodes often consist of a combination of the above metal and ceramic materials. In industry, Alcoa and Rio Tinto have formed a joint venture, Elysis, to commercialize inert anode technology developed by Alcoa. The inert anode is a cermet material, a metallic dispersion of copper alloy in a ceramic matrix of nickel ferrite. Unfortunately, as the number of anode components increases , the structure of the anode becomes more unstable. As a result. cermet anodes also suffer from corrosion issues during reduction. | 0 | Metallurgy |
Barley yellow dwarf virus 5' UTR is a non-coding RNA element containing structural elements required for translation of the genome of the plant disease pathogen Barley yellow dwarf virus.
Unlike eukaryotic mRNA, this virus lacks a 5 cap and a poly(A) tail but still circularises its mRNA through base pairing between two stem loops, one located in the 5 untranslated region (UTR) and the other within the 3 UTR. The structure within the 3 UTR has been previously characterised as the 3 cap-independent translation element (3 TE element) and the 5 UTR of barley yellow dwarf virus has been predicted to contain 4 stem loop structures. Mutagenesis showed that stem loop 4 is essential for base pairing with 3TE and only 5 bases are needed to base pair for mRNA circularization to occur. | 1 | Gene expression + Signal Transduction |
In most of today's smelting, aluminum ore, also known as bauxite, is first smelted into alumina through the Bayer Process. This step could be replaced by the Pedersen process -- either result in alumina. Unlike the smelting processes of iron and coal into steel or copper and tin into bronze, which require thermal energy, alumina must be smelted with electrical energy. This is done through the Hall–Héroult process, producing 99.5–99.8% pure aluminum. | 0 | Metallurgy |
Silicon carbide, dissolved in a basic oxygen furnace used for making steel, acts as a fuel. The additional energy liberated allows the furnace to process more scrap with the same charge of hot metal. It can also be used to raise tap temperatures and adjust the carbon and silicon content. Silicon carbide is cheaper than a combination of ferrosilicon and carbon, produces cleaner steel and lower emissions due to low levels of trace elements, has a low gas content, and does not lower the temperature of steel. | 0 | Metallurgy |
Investigators have hypothesized that the PHLPP isoforms may play roles in cancer, for several reasons. First, the genetic loci coding for PHLPP1 and 2 are commonly lost in cancer. The region including PHLPP1, 18q21.33, commonly undergoes loss of heterozygosity (LOH) in colon cancers, while 16q22.3, which includes the PHLPP2 gene, undergoes LOH in breast and ovarian cancers, Wilms tumors, prostate cancer and hepatocellular carcinoma. Second, experimental overexpression of PHLPP in cancer cell lines tends to decrease apoptosis and increase proliferation, and stable colon and glioblastoma cell lines overexpressing PHLPP1 show decreased tumor formation in xenograft models. Recent studies have also shown that Bcr-Abl, the fusion protein responsible for chronic myelogenous leukemia (CML), downregulates PHLPP1 and PHLPP2 levels, and that decreasing PHLPP levels interferes with the efficacy of Bcr-Abl inhibitors, including Gleevec, in CML cell lines.
Finally, both Akt and PKC are known to be tumor promoters, suggesting that their negative regulator PHLPP may act as a tumor suppressor. | 1 | Gene expression + Signal Transduction |
The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the receptor consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. The ligand-binding sites of the receptors are located to the three first immunoglobulin-like domains. PDGF-CC specifically interacts with PDGFR-αα and -αβ, but not with -ββ, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-ββ with high affinity, and to PDGFR-αβ to a markedly lower extent and is therefore regarded as PDGFR-ββ specific. PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.
Dimerization is a prerequisite for the activation of the kinase. Kinase activation is visualized as tyrosine phosphorylation of the receptor molecules, which occurs between the dimerized receptor molecules (transphosphorylation). In conjunction with dimerization and kinase activation, the receptor molecules undergo conformational changes, which allow a basal kinase activity to phosphorylate a critical tyrosine residue, thereby "unlocking" the kinase, leading to full enzymatic activity directed toward other tyrosine residues in the receptor molecules as well as other substrates for the kinase.
Expression of both receptors and each of the four PDGFs is under independent control, giving the PDGF/PDGFR system a high flexibility. Different cell types vary greatly in the ratio of PDGF isoforms and PDGFRs expressed. Different external stimuli such as inflammation, embryonic development or differentiation modulate cellular receptor expression allowing binding of some PDGFs but not others. Additionally, some cells display only one of the PDGFR isoforms while other cells express both isoforms, simultaneously or separately. | 1 | Gene expression + Signal Transduction |
The American Institute of Mining, Metallurgical, and Petroleum Engineers (AIME) is a professional association for mining and metallurgy, with over 145,000 members. The association was founded in 1871 by 22 mining engineers in Wilkes-Barre, Pennsylvania, and was one of the first national engineering societies in the country.
The association's charter is to "advance and disseminate, through the programs of the Member Societies, knowledge of engineering and the arts and sciences involved in the production and use of minerals, metals, energy sources and materials for the benefit of humankind."
It is the parent organization of four Member Societies, the Society for Mining, Metallurgy, and Exploration (SME), The Minerals, Metals & Materials Society (TMS), the Association for Iron and Steel Technology (AIST), and the Society of Petroleum Engineers (SPE). The organization is currently based in San Ramon, California. | 0 | Metallurgy |
Nickel monosilicide can be prepared by depositing a nickel layer on silicon and subsequent annealing. In the case of Ni films with thicknesses above 4 nm, the normal phase transition is given by NiSi at 250 °C followed by NiSi at 350 °C and NiSi at approximately 800 °C. For films with an initial Ni thickness below 4 nm a direct transition from orthorhombic NiSi to epitaxial NiSi, skipping the nickel monosilicide phase, is observed. | 0 | Metallurgy |
Prp24 interacts with the U6 snRNA via its RRMs. It has been shown through chemical modification testing that nucleotides 39–57 of U6 (40–43 in particular) are involved in binding Prp24.
The LSm proteins are in a consistent configuration on the U6 RNA. It has been proposed that the LSm proteins and Prp24 interact both physically and functionally and the C-terminal motif of Prp24 is important for this interaction. The binding of Prp24 to U6 is enhanced by the binding of Lsm proteins to U6, as is binding of U4 and U6. It was revealed by electron microscopy that Prp24 may interact with the LSm protein ring at LSm2. | 1 | Gene expression + Signal Transduction |
Mathematically, the stress at some point in the material is a plane stress if one of the three principal stresses (the eigenvalues of the Cauchy stress tensor) is zero. That is, there is Cartesian coordinate system in which the stress tensor has the form
For example, consider a rectangular block of material measuring 10, 40 and 5 cm along the , , and , that is being stretched in the direction and compressed in the direction, by pairs of opposite forces with magnitudes 10 N and 20 N, respectively, uniformly distributed over the corresponding faces. The stress tensor inside the block will be
More generally, if one chooses the first two coordinate axes arbitrarily but perpendicular to the direction of zero stress, the stress tensor will have the form
and can therefore be represented by a 2 × 2 matrix, | 0 | Metallurgy |
* The results are aesthetically pleasing.
* Creates a clean, smooth surface that is easier to sterilise.
* Can polish areas that are inaccessible by other polishing methods.
* Removes a small amount of material (typically 20-40 micrometre in depth in the case of stainless steel) from the surface of the parts, while also removing small burrs or high spots. It can be used to reduce the size of parts when necessary.
* Stainless steel preferentially removes iron from the surface and enhances the chromium/nickel content for the most superior form of passivation for stainless steel.
* Electropolishing can be used on a wide range of metals including stainless steel, aluminum, copper, brass and titanium. | 0 | Metallurgy |
Small quantities of hydrogen present inside certain metallic materials make the latter brittle and susceptible to sub-critical crack growth under stress. Hydrogen embrittlement may occur as a side effect of electroplating processes.
Delayed failure is the fracture of a component under stress after an elapsed time, is a characteristic feature of hydrogen embrittlement (2). Hydrogen entry into the material may be effected during plating, pickling, phosphating, melting, casting or welding. Corrosion during service in moist environments generates hydrogen, part of which may enter the metal as atomic hydrogen (H) and cause embrittlement. Presence of a tensile stress, either inherent or externally applied, is necessary for metals to be damaged. As in the case of stress corrosion cracking, hydrogen embrittlement may also lead to a decrease in the threshold stress intensity factor for crack propagation or an increase in the sub-critical crack growth velocity of the material. The most visible effect of hydrogen in materials is a drastic reduction in ductility during tensile tests. It may increase, decrease or leave unaffected the yield strength of the material.
Hydrogen may also cause serrated yielding in certain metals such as niobium, nickel and some steels (3). | 0 | Metallurgy |
This section is not concerned with sculpture in bronze, but rather with the many artistic applications of the metal in connection with architecture, or with objects for ecclesiastical and domestic use. Why bronze was preferred in Italy, iron in Spain and Germany and brass in the Low Countries cannot be satisfactorily determined; national temperamente is impressed on the choice of metals and also on the methods of working them. Centres of artistic energy shift from one place to another owing to wars, conquests or migrations. | 0 | Metallurgy |
All metals can be classified into a galvanic series representing the electrical potential they develop in a given electrolyte against a standard reference electrode. The relative position of two metals on such a series gives a good indication of which metal is more likely to corrode more quickly. However, other factors such as water aeration and flow rate can influence the rate of the process markedly. | 0 | Metallurgy |
There are two drivers for spalling of concrete: thermal strain caused by rapid heating and internal pressures due to the removal of water. Being able to predict the outcome of different heating rates on thermal stresses and internal pressure during water removal is particularly important to industry and other concrete structures.
Explosive spalling events of refractory concrete can result in serious problems. If an explosive spalling occurs, projectiles of reasonable mass (1–10 kg) can be thrust violently over many metres, which will have safety implications and render the refractory structure unfit for service. Repairs will then be required resulting in significant costs to industry. | 0 | Metallurgy |
If there are additional factors preventing boundary movement, such as Zener pinning by particles, then the grain size may be restricted to a much lower value than might otherwise be expected. This is an important industrial mechanism in preventing the softening of materials at high temperature. | 0 | Metallurgy |
Many different proteins bind to particular TET enzymes and recruit the TETs to specific genomic locations. In some studies, further analysis is needed to determine whether the interaction per se mediates the recruitment or instead the interacting partner helps to establish a favourable chromatin environment for TET binding. TET1‑depleted and TET2‑depleted cells revealed distinct target preferences of these two enzymes, with TET1‑preferring promoters and TET2‑preferring gene bodies of highly expressed genes and enhancers.
The three mammalian DNA methyltransferases (DNMTs) show a strong preference for adding a methyl group to the 5 carbon of a cytosine where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5 → 3 direction (at CpG sites). This forms a 5mCpG site. More than 98% of DNA methylation occurs at CpG sites in mammalian somatic cells. Thus TET enzymes largely initiate demethylation at 5mCpG sites.
Oxoguanine glycosylase (OGG1) is one example of a protein that recruits a TET enzyme. TET1 is able to act on 5mCpG if an ROS has first acted on the guanine to form 8-hydroxy-2'-deoxyguanosine (8-OHdG or its tautomer 8-oxo-dG), resulting in a 5mCp-8-OHdG dinucleotide (see Figure). After formation of 5mCp-8-OHdG, the base excision repair enzyme OGG1 binds to the 8-OHdG lesion without immediate excision (see Figure). Adherence of OGG1 to the 5mCp-8-OHdG site recruits TET1, allowing TET1 to oxidize the 5mC adjacent to 8-OHdG. This initiates the demethylation pathway.
EGR1 is another example of a protein that recruits a TET enzyme. EGR1 has an important role in learning and memory. When a new event such as fear conditioning causes a memory to be formed, EGR1 messenger RNA is rapidly and selectively up-regulated in subsets of neurons in specific brain regions associated with learning and memory formation. TET1s is the predominant isoform of TET1 that is expressed in neurons. When EGR1 proteins are expressed, they appear to bring TET1s to about 600 sites in the neuron genome. Then EGR1 and TET1 appear to cooperate in demethylating and thereby activating the expression of genes downstream of the EGR1 binding sites in DNA. | 1 | Gene expression + Signal Transduction |
There are three stages in the post-Soviet history of Ural metallurgy:
* 1991-1994 - adaptation to market conditions, search for sources of raw materials and sales markets, accumulation of working capital.
* 1994-2003 - formation of vertically integrated companies and their development.
* since 2003 - modernization of enterprises within vertically integrated companies.
Restructuring and the transition to market conditions led to a 2-fold reduction in production at the Ural metallurgical enterprises. The Nizhniy Tagil and Orsko-Khalilovsky plants went bankrupt. Some enterprises went through bankruptcy proceedings several times. The privatization and corporatization of the enterprises of the Ural metallurgy were completed in 1992-1994. In the late 1990s - early 2000s, vertically integrated structures began to form around large enterprises, including all stages of a closed technological cycle. In addition to the Magnitogorsk Metallurgical Combine, the MMK Group includes: the Magnitogorsk Hardware, Metallurgical, and Calibration Plants; the Mechel group united the Chelyabinsk Metallurgical Plant, Yuzhuralnickel, Beloretsk Metallurgical Plant, Izhstal, and Korshunovsky Mining and Processing Plant; NTMK and Kachkanarsky Mining and Processing Plant, together with the West Siberian and Kuznetsk metallurgical plants, entered Evraz-holding; Chelyabinsk Pipe Rolling Plant and Pervouralsk Novotrubny Plants were merged into the ChTPZ Group; copper smelters became part of UMMC and Russian Copper Company; aluminum - Rusal and SUAL, united in 2007.
The main directions of development of ferrous metallurgy in the Urals in the market conditions were the reconstruction of blast furnaces with optimization of the profile and process control systems, the replacement of open-hearth furnaces with oxygen converters and electric furnaces, the widespread introduction of out-of-furnace steel processing, evacuation of steel before casting, as well as an increase in the share of continuous casting of steel. From 1985 to 2000, the share of the Ural steel smelted by the open-hearth method decreased from 78.2% to 46.9%; the share of converter steel in the same period increased from 15% to 46.9%, the share of continuously cast steel - from 1.2% to 33.1%. The share of electric steel in the same period remained at the level of about 6-7%.
After the reconstruction and launch of new capacities, about 85% of the Ural steel was produced at the 4 largest metallurgical plants: MMK (39.1% of the total steel volume in 2006), NTMK (17.6%), Mechel (15.2% ), and Ural steel (11.4%).
In the late 20th - early 21st century, the Ural metallurgical plants are developing taking into account the interests of holding structures. The main directions of development are the automation of production and the minimization of costs. Key investment development projects are the reconstruction of the converter shop and the construction of a pulverized coal injection unit at NTMK in 2010-2012, the launch in 2010 of the "Vysota 239" large-diameter pipe production shop at ChTPZ, as well as the launch in 2009 of Mill-5000 at MMK, which supplies workpieces including for the new ChelPipe workshop. By 2014, the share of Ural steel processed by the out-of-furnace method and poured at the continuous casting machine was brought to 100%.
In 2008, the Ural plants produced 43.1% of all-Russian pig iron, 43.4% of steel, 43.4% of rolled products, 46.4% of pipes, 47.9% of hardware, 72.8% of ferroalloys, about 80% of bauxite, 60% of alumina, 36% of refined copper, 100% of titanium and magnesium alloys, 64% of zinc, 15% of lead, and 8% of aluminum. The largest contribution to the metallurgy of the region is made by enterprises of the Chelyabinsk and Sverdlovsk Oblasts. As of 2013, the contribution of the Ural enterprises was estimated at 38% of steel and rolled products and about 50% of steel pipes. | 0 | Metallurgy |
Like any mechanical and physical entity there are scientific, industrial, and layman terminology. The following is a partial list of terms that are associated with mechanical screening.
*Amplitude - This is a measurement of the screen cloth as it vertically peaks to its tallest height and troughs to its lowest point. Measured in multiples of the acceleration constant g (g-force).
*Acceleration - Applied Acceleration to the screen mesh in order to overcome the van der waal forces
*Blinding - When material plugs into the open slots of the screen cloth and inhibits overflowing material from falling through.
*Brushing - This procedure is performed by an operator who uses a brush to brush over the screen cloth to dislodged blinded opening.
*Contamination - This is unwanted material in a given grade. This occurs when there is oversize or fine size material relative to the cut or grade. Another type of contamination is foreign body contamination.
**Oversize contamination occurs when there is a hole in the screen such that the hole is larger than the mesh size of the screen. Other instances where oversize occurs is material overflow falling into the grade from overhead, or there is the wrong mesh size screen in place.
**Fines contamination is when large sections of the screen cloth is blinded over, and material flowing over the screen does not fall through. The fines are then retained in the grade.
**Foreign body contamination is unwanted material that differs from the virgin material going over and through the screen. It can be anything ranging from tree twigs, grass, metal slag to other mineral types and composition. This contamination occurs when there is a hole in the scalping screen or a foreign material's mineralogy or chemical composition differs from the virgin material.
*Deck - a deck is frame or apparatus that holds the screen cloth in place. It also contains the screening drive. It can contain multiple sections as the material travels from the feed end to the discharge end. Multiple decks are screen decks placed in a configuration where there are a series of decks attached vertically and lean at the same angle as it preceding and exceeding decks. Multiple decks are often referred to as single deck, double deck, triple deck, etc.
*Frequency - Measured in hertz (Hz) or revolutions per minute (RPM). Frequency is the number of times the screen cloth sinusoidally peaks and troughs within a second. As for a gyratory screening motion it is the number of revolutions the screens or screen deck takes in a time interval, such as revolution per minute (RPM).
*Gradation, grading - Also called "cut" or "cutting." Given a feed material in an initial state, the material can be defined to have a particle size distribution. Grading is removing the maximum size material and minimum size material by way of mesh selection.
*Screen Media (Screen cloth) - it is the material defined by mesh size, which can be made of any type of material such steel, stainless steel, rubber compounds, polyurethane, brass, etc.
*Shaker - the whole assembly of any type mechanical screening machine.
*Stratification - This phenomenon occurs as vibration is passed through a bed of material. This causes coarse (larger) material to rise and finer (smaller) material to descend within the bed. The material in contact with screen cloth either falls through a slot or blinds the slot or contacts the cloth material and is thrown from the cloth to fall to the next lower level.
*Mesh - The number of open slots per linear inch. Mesh is arranged in multiple configuration. Mesh can be a square pattern, long-slotted rectangular pattern, circular pattern, or diamond pattern.
*Scalp, scalping - this is the very first cut of the incoming material with the sum of all its grades. Scalping is removing the largest size particles. This includes enormously large particles relative to the other particle's sizes. Scalping also cleans the incoming material from foreign body contamination such as twigs, trash, glass, or other unwanted oversize material. | 0 | Metallurgy |
Scleroderma, also known as systemic sclerosis, is a chronic systemic autoimmune disease characterised by hardening (sclero) of the skin (derma) that affects internal organs in its more severe forms. mTOR plays a role in fibrotic diseases and autoimmunity, and blockade of the mTORC pathway is under investigation as a treatment for scleroderma. | 1 | Gene expression + Signal Transduction |
The continuous process of applying up to three separate coating layers onto one or both sides of a metal strip substrate occurs on a coil coating line. These lines vary greatly in size, with widths from and speeds from ; however, all coil-coating lines share the same basic process steps.
A typical organic coil coating line consists of decoilers, entry strip accumulator, cleaning, chemical pretreatment, primer coat application, curing, final coat application, curing, exit accumulator and recoilers.
The following steps take place on a modern coating line:
* Mechanical stitching of the strip to its predecessor
* Cleaning the strip
* Power brushing
* Surface treatment by chemical conversion
* Drying the strip
* Application of primer on one or both sides
* Passage through the first curing oven (between 15 and 60 seconds)
* Cooling the strip
* Coating the finish on one or both sides
* Passage through the second curing oven (between 15 and 60 seconds)
* Cooling down to room temperature
* Rewinding of the coated coil | 0 | Metallurgy |
Upregulation refers to the increase in the number of receptor sites on the membrane. Estrogen upregulates FSH receptor sites. In turn, FSH stimulates granulosa cells to produce estrogens. This synergistic activity of estrogen and FSH allows for follicle growth and development in the ovary. | 1 | Gene expression + Signal Transduction |
By the 12th century the Italian craftsmen had developed a style of their own, as may be seen in the bronze doors of Saint Zeno, Verona (which are made of hammered and not cast bronze), Ravello, Trani and Monreale. Bonanno da Pisa made a series of doors for the duomo of that city, one pair of which remains. The 14th century witnessed the birth of a great revival in the working of bronze, which was destined to flourish for at least four centuries. Bronze was a metal beloved of the Italian craftsman; in that metal he produced objects for every conceivable purpose, great or small, from a door-knob to the mighty doors by Lorenzo Ghiberti at Florence, of which Michelangelo remarked that they would stand well at the gates of Paradise. Nicola, Giovanni and Andrea Pisano, Ghiberti, Brunelleschi, Donatello, Verrocchio, Cellini, Michelangelo, Giovanni da Bologna — these and many others produced great works in bronze.
Benedetto da Rovezzano came to England in 1524 to execute a tomb for Cardinal Wosley, part of which, after many vicissitudes, is now in the crypt of St Paul's Cathedral. Pietro Torrigiano of Florence executed the tomb of Henry VII in Westminster Abbey. Alessandro Leopardi, at the beginning of the 16th century, completed the three admirable sockets for flag-staffs which still adorn the Piazza San Marco, Venice. A further development showed itself in the production of portrait medals in bronze, which reached a high degree of perfection and engaged the attention of many celebrated artists. Bronze plaquettes for the decoration of large objects exhibit a fine sense of design and composition. Of smaller objects, for church and domestic use, the number was legion. Among the former may be mentioned crucifixes, shrines, altar and paschal candlesticks, such as the elaborate examples at the Certosa of Pavia; for secular use, mortars, inkstands, candlesticks and a large number of splendid door-knockers and handles, all executed with consummate skill and perfection of finish. Work of this kind continued to be made throughout the 17th and 18th centuries. | 0 | Metallurgy |
There are two common mathematical descriptions of the work hardening phenomenon. Hollomon's equation is a power law relationship between the stress and the amount of plastic strain:
where σ is the stress, K is the strength index or strength coefficient, ε is the plastic strain and n is the strain hardening exponent. Ludwik's equation is similar but includes the yield stress:
If a material has been subjected to prior deformation (at low temperature) then the yield stress will be increased by a factor depending on the amount of prior plastic strain ε:
The constant K is structure dependent and is influenced by processing while n is a material property normally lying in the range 0.2–0.5. The strain hardening index can be described by:
This equation can be evaluated from the slope of a log(σ) – log(ε) plot. Rearranging allows a determination of the rate of strain hardening at a given stress and strain: | 0 | Metallurgy |
Reciprocal silencing, a genetic phenomenon that primarily occurs in plants, refers to the pattern of redundant genes being silenced following a polyploid event. Polyploidy (wholesale genome duplication) is common in plants and constitutes an important method of speciation. When a polyploid species arises, its genome contains homoeologs, duplicated chromosomes with equivalent genetic information. However silencing of redundant genes occurs rapidly in new polyploids through genetic and epigenetic means. This primarily occurs because redundancy allows one of the two genes present for each locus to be silenced without affecting the phenotype of the organism, and thus mutations that eliminate gene expression are much less likely to be deleterious or lethal. This allows mutations that would be lethal in diploid populations to accumulate in polyploids. Reciprocal silencing refers to the specific pattern of silencing where equivalent loci in are both silenced and expressed in a reciprocal manner. This phenomenon is observed on two distinct scales. | 1 | Gene expression + Signal Transduction |
In 1982, a diver discovered a shipwreck off the shore of Uluburun, Turkey. The ship contained 317 copper ingots in the normal oxhide shape, 36 with only two corner protrusions, 121 shaped like buns, and five shaped like pillows. The oxhide ingots (ingots with two or four protrusions) range in weight from after being cleaned of their corrosion. These ingots were found stacked in four rows following a herringbone pattern. The smooth sides of the ingots faced downwards, and the lowest layer rested on brushwood. There are three whole tin oxhide ingots, and there are many tin ingots cut into quarters or halves, with their corner protrusion(s) still intact. Besides metal ingots, the cargo included ivory, metal jewelry, and Mycenaean, Cypriot, and Canaanite pottery. Tree-ring dating of firewood from the ship gives an approximate date of 1300 BC. More than 160 copper oxhide ingots, 62 bun ingots, and some of the tin oxhide ingots have incised marks typically on their rough sides. Some of these marks—resembling fish, oars, and boats—relate to the sea, and they were probably incised after casting, when the ingot was received or exported.
Recently Yuval Goren proposed that the ten tons of copper ingots, one ton of tin ingots, and the resin stored in the Canaanite jars aboard the ship were one complete package. The recipients of the copper, tin, and resin would have used these materials for bronze casting through the lost-wax technique. | 0 | Metallurgy |
The principal mission of iron foundry is the conversion of iron oxides (purified iron ores) to iron metal. This reduction is usually effected using a reducing atmosphere consisting of some mixture of natural gas, hydrogen (H), and carbon monoxide. The byproduct is carbon dioxide. | 0 | Metallurgy |
The patio process is a process for extracting silver from ore. Smelting, or refining, is most often necessary because silver is only infrequently found as a native element like some metals nobler than the redox couple 2 + 2 ⇌ (gold, mercury, ...). Instead, it is made up of a larger ore body. Thus, smelting, or refining, is necessary to reduce the compound containing the cation into metallic Ag and to remove other byproducts to get at pure silver. The process, which uses mercury amalgamation to recover silver from ore, was first used at scale by Bartolomé de Medina in Pachuca, Mexico, in 1554. It replaced smelting as the primary method of extracting silver from ore at Spanish colonies in the Americas. Although some knowledge of amalgamation techniques were likely known since the classical era, it was in the New World that it was first used on a large industrial scale. Other amalgamation processes were later developed, importantly the pan amalgamation process, and its variant, the Washoe process. The silver separation process generally differed from gold parting and gold extraction, although amalgamation with mercury is also sometimes used to extract gold. While gold was often found in the Americas as a native metal or alloy, silver was often found as a compound such as silver chloride and silver sulfide, and therefore required mercury amalgamation for refinement. | 0 | Metallurgy |
Roasting is a process of heating a sulfide ore to a high temperature in the presence of air. It is a step in the processing of certain ores. More specifically, roasting is often a metallurgical process involving gas–solid reactions at elevated temperatures with the goal of purifying the metal component(s). Often before roasting, the ore has already been partially purified, e.g. by froth flotation. The concentrate is mixed with other materials to facilitate the process. The technology is useful in making certain ores usable but it can also be a serious source of air pollution.
Roasting consists of thermal gas–solid reactions, which can include oxidation, reduction, chlorination, sulfation, and pyrohydrolysis. In roasting, the ore or ore concentrate is treated with very hot air. This process is generally applied to sulfide minerals. During roasting, the sulfide is converted to an oxide, and sulfur is released as sulfur dioxide, a gas. For the ores CuS (chalcocite) and ZnS (sphalerite), balanced equations for the roasting are:
:2 CuS + 3 O → 2 CuO + 2 SO
:2 ZnS + 3 O → 2 ZnO + 2 SO
The gaseous product of sulfide roasting, sulfur dioxide (SO) is often used to produce sulfuric acid. Many sulfide minerals contain other components such as arsenic that are released into the environment.
Up until the early 20th century, roasting was started by burning wood on top of ore. This would raise the temperature of the ore to the point where its sulfur content would become its source of fuel, and the roasting process could continue without external fuel sources. Early sulfide roasting was practiced in this manner in "open hearth" roasters, which were manually stirred (a practice called "rabbling") using rake-like tools to expose unroasted ore to oxygen as the reaction proceeded.
This process released large amounts of acidic, metallic, and other toxic compounds. Results of this include areas that even after 60–80 years are still largely lifeless, often exactly corresponding to the area of the roast bed, some of which are hundreds of metres wide by kilometres long. Roasting is an exothermic process. | 0 | Metallurgy |
In humans, about 70% of promoters located near the transcription start site of a gene (proximal promoters) contain a CpG island. CpG islands are generally 200 to 2000 base pairs long, have a C:G base pair content >50%, and have regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide and this occurs frequently in the linear sequence of bases along its 5 → 3 direction.
Distal promoters also frequently contain CpG islands, such as the promoter of the DNA repair gene ERCC1, where the CpG island-containing promoter is located about 5,400 nucleotides upstream of the coding region of the ERCC1 gene. CpG islands also occur frequently in promoters for functional noncoding RNAs such as microRNAs. | 1 | Gene expression + Signal Transduction |
As the smelting stage is necessary to obtain alloys and shape the product, direct reduction processes are frequently combined with downstream smelting facilities.
Most pre-reduced iron ore is smelted in electric furnaces: in 2003, 49 of the 50 Mt produced went into electric furnaces. Process integration is generally highly advanced, to take advantage of the high temperature (over 600 °C) of the prereduct from the direct reduction reactor.
One idea is to carry out the entire reduction-melting process in the arc furnace installed downstream of the reduction plant. Several plasma processes operating above 1530 °C have been devised and sometimes tested. Furnaces can be either non-transferred arc (Plasmasmelt, Plasmared) or transferred arc (ELRED, EPP, SSP, The Toronto System, falling plasma film reactor). All these processes share the electric furnace's advantage of low investment cost, and its disadvantage of using an expensive energy source. In the case of direct reduction, this disadvantage is outweighed by the fact that a great deal of heat is required, both for the reduction process and because of the gangue to be melted.
An alternative to the electric furnace is to melt the pre-reduction with a fuel. The cupola furnace is ideally suited to this task, but since one reason for the existence of direct reduction processes is the non-use of coke, other melting furnaces have emerged. The COREX process, in operation since 1987, consists of a direct-reduction shaft reactor feeding a blast furnace crucible, in which the pre-reduced ore is brought to a liquid smelting state, consuming only coal. This process also produces a hot reducing gas, which can be valorized in a Midrex-type unit. An equivalent to COREX, based on the FINMET fluidized bed instead of the Midrex vessel, is the Korean FINEX process (a contraction of FINMET and COREX). Both processes are in industrial operation at several plants around the world.
Last but not least, a number of reduction-melting furnaces in the same reactor have been studied, but have not yet led to industrial development. For example, the ISARNA process and its derivative HISARNA (a combination of the ISARNA and HISMELT processes), is a cyclonic reactor that performs melting before reduction. These processes have culminated in an industrial demonstrator tested in the Netherlands since 2011. Similarly, Japanese steelmakers joined forces in the 1990s to develop the DIOS process which, like many reduction-fusion processes, is similar to oxygen converters. The TECNORED process, studied in Brazil, also performs reduction-melting in the same vessel, but is more akin to a blast furnace modified to adapt to any type of solid fuel. Of all the processes of this type that have been developed, a single ISASMELT-type industrial unit built in Australia, with a capacity of 0.8 Mt/year, operated from 2005 to 2008 before being dismantled and shipped to China, where it was restarted in 2016. | 0 | Metallurgy |
To facilitate further preparation, the sawed specimen is usually embedded (or mounted or encapsulated) in a plastic disc, 25, 32 or 38 mm in diameter. A thermosetting solid resin, activated by heat and compression, e.g. mineral-filled epoxy, is best for most applications. A castable (liquid) resin such as unfilled epoxy, acrylic or polyester may be used for porous refractory ceramics or microelectronic devices. The castable resins are also available with fluorescent dyes that aid in fluorescence microscopy. The left and right specimens in Fig. 3 were embedded in mineral-filled epoxy. The center refractory in Fig. 3 was embedded in castable, transparent acrylic. | 0 | Metallurgy |
Bidirectional promoters are short (<1 kbp) intergenic regions of DNA between the 5 ends of the genes in a bidirectional gene pair. A “bidirectional gene pair” refers to two adjacent genes coded on opposite strands, with their 5 ends oriented toward one another. The two genes are often functionally related, and modification of their shared promoter region allows them to be co-regulated and thus co-expressed. Bidirectional promoters are a common feature of mammalian genomes. About 11% of human genes are bidirectionally paired.
Bidirectionally paired genes in the Gene Ontology database shared at least one database-assigned functional category with their partners 47% of the time. Microarray analysis has shown bidirectionally paired genes to be co-expressed to a higher degree than random genes or neighboring unidirectional genes. Although co-expression does not necessarily indicate co-regulation, methylation of bidirectional promoter regions has been shown to downregulate both genes, and demethylation to upregulate both genes. There are exceptions to this, however. In some cases (about 11%), only one gene of a bidirectional pair is expressed. In these cases, the promoter is implicated in suppression of the non-expressed gene. The mechanism behind this could be competition for the same polymerases, or chromatin modification. Divergent transcription could shift nucleosomes to upregulate transcription of one gene, or remove bound transcription factors to downregulate transcription of one gene.
Some functional classes of genes are more likely to be bidirectionally paired than others. Genes implicated in DNA repair are five times more likely to be regulated by bidirectional promoters than by unidirectional promoters. Chaperone proteins are three times more likely, and mitochondrial genes are more than twice as likely. Many basic housekeeping and cellular metabolic genes are regulated by bidirectional promoters.
The overrepresentation of bidirectionally paired DNA repair genes associates these promoters with cancer. Forty-five percent of human somatic oncogenes seem to be regulated by bidirectional promoters – significantly more than non-cancer causing genes. Hypermethylation of the promoters between gene pairs WNT9A/CD558500, CTDSPL/BC040563, and KCNK15/BF195580 has been associated with tumors.
Certain sequence characteristics have been observed in bidirectional promoters, including a lack of TATA boxes, an abundance of CpG islands, and a symmetry around the midpoint of dominant Cs and As on one side and Gs and Ts on the other. A motif with the consensus sequence of TCTCGCGAGA, also called the CGCG element, was recently shown to drive PolII-driven bidirectional transcription in CpG islands. CCAAT boxes are common, as they are in many promoters that lack TATA boxes. In addition, the motifs NRF-1, GABPA, YY1, and ACTACAnnTCCC are represented in bidirectional promoters at significantly higher rates than in unidirectional promoters. The absence of TATA boxes in bidirectional promoters suggests that TATA boxes play a role in determining the directionality of promoters, but counterexamples of bidirectional promoters do possess TATA boxes and unidirectional promoters without them indicates that they cannot be the only factor.
Although the term "bidirectional promoter" refers specifically to promoter regions of mRNA-encoding genes, luciferase assays have shown that over half of human genes do not have a strong directional bias. Research suggests that non-coding RNAs are frequently associated with the promoter regions of mRNA-encoding genes. It has been hypothesized that the recruitment and initiation of RNA polymerase II usually begins bidirectionally, but divergent transcription is halted at a checkpoint later during elongation. Possible mechanisms behind this regulation include sequences in the promoter region, chromatin modification, and the spatial orientation of the DNA. | 1 | Gene expression + Signal Transduction |
The history of ferrous metallurgy in the Indian subcontinent began in the 2nd millennium BC. Archaeological sites in Gangetic plains have yielded iron implements dated between 1800 and 1200 BC. By the early 13th century BC, iron smelting was practiced on a large scale in India. In Southern India (present day Mysore) iron was in use 12th to 11th centuries BC. The technology of iron metallurgy advanced in the politically stable Maurya period and during a period of peaceful settlements in the 1st millennium BC.
Iron artifacts such as spikes, knives, daggers, arrow-heads, bowls, spoons, saucepans, axes, chisels, tongs, door fittings, etc., dated from 600 to 200 BC, have been discovered at several archaeological sites of India. The Greek historian Herodotus wrote the first western account of the use of iron in India. The Indian mythological texts, the Upanishads, have mentions of weaving, pottery and metallurgy, as well. The Romans had high regard for the excellence of steel from India in the time of the Gupta Empire.
Perhaps as early as 500 BC, although certainly by 200 AD, high-quality steel was produced in southern India by the crucible technique. In this system, high-purity wrought iron, charcoal, and glass were mixed in a crucible and heated until the iron melted and absorbed the carbon. Iron chain was used in Indian suspension bridges as early as the 4th century.
Wootz steel was produced in India and Sri Lanka from around 300 BC. Wootz steel is famous from Classical Antiquity for its durability and ability to hold an edge. When asked by King Porus to select a gift, Alexander is said to have chosen, over gold or silver, thirty pounds of steel. Wootz steel was originally a complex alloy with iron as its main component together with various trace elements. Recent studies have suggested that its qualities may have been due to the formation of carbon nanotubes in the metal. According to Will Durant, the technology passed to the Persians and from them to Arabs who spread it through the Middle East. In the 16th century, the Dutch carried the technology from South India to Europe, where it was mass-produced.
Steel was produced in Sri Lanka from 300 BC by furnaces blown by the monsoon winds. The furnaces were dug into the crests of hills, and the wind was diverted into the air vents by long trenches. This arrangement created a zone of high pressure at the entrance, and a zone of low pressure at the top of the furnace. The flow is believed to have allowed higher temperatures than bellows-driven furnaces could produce, resulting in better-quality iron. Steel made in Sri Lanka was traded extensively within the region and in the Islamic world.
One of the world's foremost metallurgical curiosities is an iron pillar located in the Qutb complex in Delhi. The pillar is made of wrought iron (98% Fe), is almost seven meters high and weighs more than six tonnes. The pillar was erected by Chandragupta II Vikramaditya and has withstood 1,600 years of exposure to heavy rains with relatively little corrosion. | 0 | Metallurgy |
Nonsense mutations are changes in DNA sequence that introduce a premature stop codon, causing any resulting protein to be abnormally shortened. This often causes a loss of function in the protein, as critical parts of the amino acid chain are no longer assembled. Because of this terminology, stop codons have also been referred to as nonsense codons. | 1 | Gene expression + Signal Transduction |
Early diagnosis and analysis of seemingly healthy concrete cover and reinforcement status allows pre-emptive corrosion control measures to reduce unwanted risks to structural safety. Bundesanstalt für Materialforschung und -prüfung (Federal Institute for Materials Research and Testing, Germany) has developed a sensor equipped robotic system to accelerate the collection of several criteria used for diagnostics. Besides ultrasonic, ground-penetrating radar, concrete resistance, potential field, the eddy current method implemented in the Profometer 5 was used to measure the concrete cover. | 0 | Metallurgy |
The collision rates for fine particles (50 - 80 μm) can be accurately modeled, but there is no current theory that accurately models bubble-particle collision for particles as large as 300 μm, which are commonly used in flotation processes.
For fine particles, Stokes law underestimates collision probability while the potential equation based on surface charge overestimates collision probability so an intermediate equation is used.
It is important to know the collision rates in the system since this step precedes the adsorption where a three phase system is formed. | 0 | Metallurgy |
The earliest and most diverse finds of metal artifacts are from West Mexico stretching in a belt along the Pacific coast from Guerrero to Nayarit. This indicates that this region was a regional nucleus of metallurgy, from which elements of technique, form and style could have diffused throughout Mesoamerica. | 0 | Metallurgy |
TET processivity can be viewed at three levels, the physical, chemical and genetic levels. Physical processivity refers to the ability of a TET protein to slide along the DNA from one CpG site to another. An in vitro study showed that DNA-bound TET does not preferentially oxidize other CpG sites on the same DNA molecule, indicating that TET is not physically processive. Chemical processivity refers to the ability of TET to catalyze the oxidation of 5mC iteratively to 5caC without releasing its substrate. It appears that TET can work through both chemically processive and non‑processive mechanisms depending on reaction conditions. Genetic processivity refers to the genetic outcome of TET‑mediated oxidation in the genome, as shown by mapping of the oxidized bases. In mouse embryonic stem cells, many genomic regions or CpG sites are modified so that 5mC is changed to 5hmC but not to 5fC or 5caC, whereas at many otherCpG sites 5mCs are modified to 5fC or 5caC but not 5hmC, suggesting that 5mC is processed to different states at different genomic regions or CpG sites. | 1 | Gene expression + Signal Transduction |
The olfactory receptor neuron has a fast working negative feedback response upon depolarization. When the neuron is depolarizing, the CNG ion channel is open allowing sodium and calcium to rush into the cell. The influx of calcium begins a cascade of events within the cell. Calcium first binds to calmodulin to form CaM. CaM will then bind to the CNG channel and close it, stopping the sodium and calcium influx. CaMKII will be activated by the presence of CaM, which will phosphorylate ACIII and reduce cAMP production. CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP. The effect of this negative feedback response inhibits the neuron from further activation when another odor molecule is introduced. | 1 | Gene expression + Signal Transduction |
Most genes considered master regulators code for transcription factor proteins, which in turn alter the expression of downstream genes in the pathway. Canonical examples of master regulators include Oct-4 (also called POU5F1), SOX2, and NANOG, all transcription factors involved in maintaining pluripotency in stem cells. Master regulators involved in development and morphogenesis can also appear as oncogenes relevant to tumorigenesis and metastasis, as with the Twist transcription factor.
Other genes reported as master regulators code for SR proteins, which function as splicing factors, and some noncoding RNAs. | 1 | Gene expression + Signal Transduction |
In wire electrical discharge machining (WEDM), also known as wire-cut EDM and wire cutting, a thin single-strand metal wire, usually brass, is fed through the workpiece, submerged in a tank of dielectric fluid, typically deionized water. Wire-cut EDM is typically used to cut plates as thick as 300mm and to make punches, tools, and dies from hard metals that are difficult to machine with other methods.
The wire, which is constantly fed from a spool, is held between upper and lower diamond guides which is centered in a water nozzle head. The guides, usually CNC-controlled, move in the x–y plane. On most machines, the upper guide can also move independently in the z–u–v axis, giving rise to the ability to cut tapered and transitioning shapes (circle on the bottom, square at the top for example). The upper guide can control axis movements in the GCode standard, x–y–u–v–i–j–k–l–. This allows the wire-cut EDM to be programmed to cut very intricate and delicate shapes.
The upper and lower diamond guides are usually accurate to , and can have a cutting path or kerf as small as using Ø wire, though the average cutting kerf that achieves the best economic cost and machining time is using Ø brass wire. The reason that the cutting width is greater than the width of the wire is because sparking occurs from the sides of the wire to the work piece, causing erosion. This "overcut" is necessary, for many applications it is adequately predictable and therefore can be compensated for (for instance in micro-EDM this is not often the case). Spools of wire are long — an 8 kg spool of 0.25 mm wire is just over 19 kilometers in length. Wire diameter can be as small as and the geometry precision is not far from ± .
The wire-cut process uses water as its dielectric fluid, controlling its resistivity and other electrical properties with filters and PID controlled de-ionizer units. The water flushes the cut debris away from the cutting zone. Flushing is an important factor in determining the maximum feed rate for a given material thickness.
Along with tighter tolerances, multi axis EDM wire-cutting machining centers have added features such as multi heads for cutting two parts at the same time, controls for preventing wire breakage, automatic self-threading features in case of wire breakage, and programmable machining strategies to optimize the operation.
Wire-cutting EDM is commonly used when low residual stresses are desired, because it does not require high cutting forces for removal of material. If the energy per pulse is relatively low (as in finishing operations), little change in the mechanical properties of a material is expected due to these low residual stresses, although material that hasn't been stress-relieved can distort in the machining process.
The work piece may undergo a significant thermal cycle, its severity depending on the technological parameters used. Such thermal cycles may cause formation of a recast layer on the part and residual tensile stresses on the work piece. If machining takes place after heat treatment, dimensional accuracy will not be affected by heat treat distortion. | 0 | Metallurgy |
Inclusions are usually other minerals or rocks, but may also be water, gas or petroleum. Liquid or vapor inclusions are known as fluid inclusions. In the case of amber it is possible to find insects and plants as inclusions.
The analysis of atmospheric gas bubbles as inclusions in ice cores is an important tool in the study of climate change.
A xenolith is a pre-existing rock which has been picked up by a lava flow. Melt inclusions form when bits of melt become trapped inside crystals as they form in the melt. | 0 | Metallurgy |
The mining and mineral processing industry uses screening for a variety of processing applications. For example, after mining the minerals, the material is transported to a primary crusher. Before crushing large boulder are scalped on a shaker with thick shielding screening. Further down stream after crushing the material can pass through screens with openings or slots that continue to become smaller. Finally, screening is used to make a final separation to produce saleable products based on a grade or a size range. | 0 | Metallurgy |
Synapses are functional connections between neurons, or between neurons and other types of cells. A typical neuron gives rise to several thousand synapses, although there are some types that make far fewer. Most synapses connect axons to dendrites, but there are also other types of connections, including axon-to-cell-body, axon-to-axon, and dendrite-to-dendrite. Synapses are generally too small to be recognizable using a light microscope except as points where the membranes of two cells appear to touch, but their cellular elements can be visualized clearly using an electron microscope.
Chemical synapses pass information directionally from a presynaptic cell to a postsynaptic cell and are therefore asymmetric in structure and function. The presynaptic axon terminal, or synaptic bouton, is a specialized area within the axon of the presynaptic cell that contains neurotransmitters enclosed in small membrane-bound spheres called synaptic vesicles (as well as a number of other supporting structures and organelles, such as mitochondria and endoplasmic reticulum). Synaptic vesicles are docked at the presynaptic plasma membrane at regions called active zones.
Immediately opposite is a region of the postsynaptic cell containing neurotransmitter receptors; for synapses between two neurons the postsynaptic region may be found on the dendrites or cell body. Immediately behind the postsynaptic membrane is an elaborate complex of interlinked proteins called the postsynaptic density (PSD).
Proteins in the PSD are involved in anchoring and trafficking neurotransmitter receptors and modulating the activity of these receptors. The receptors and PSDs are often found in specialized protrusions from the main dendritic shaft called dendritic spines.
Synapses may be described as symmetric or asymmetric. When examined under an electron microscope, asymmetric synapses are characterized by rounded vesicles in the presynaptic cell, and a prominent postsynaptic density. Asymmetric synapses are typically excitatory. Symmetric synapses in contrast have flattened or elongated vesicles, and do not contain a prominent postsynaptic density. Symmetric synapses are typically inhibitory.
The synaptic cleft—also called synaptic gap—is a gap between the pre- and postsynaptic cells that is about 20 nm (0.02 μ) wide. The small volume of the cleft allows neurotransmitter concentration to be raised and lowered rapidly.
An autapse is a chemical (or electrical) synapse formed when the axon of one neuron synapses with its own dendrites. | 1 | Gene expression + Signal Transduction |
It is thought that early scleraxis-expressing progenitor cells lead to the eventual formation of tendon tissue and other muscle attachments. Scleraxis is involved in mesoderm formation and is expressed in the syndetome (a collection of embryonic tissue that develops into tendon and blood vessels) of developing somites (primitive segments or compartments of embryos). | 1 | Gene expression + Signal Transduction |
ChimerDB in computational biology is a database of fusion sequences.
ChimerDB currently consists of three searchable datasets.
*[http://203.255.191.229:8080/chimerdbv31/mchimerkb.cdb ChimerKB] is a curated knowledge base of 1,066 fusion genes sourced from publicly available scientific literature.
*[http://203.255.191.229:8080/chimerdbv31/mchimerpub.cdb ChimerPub] provides continuously updated descriptions on fusion genes text mined from publications.
*[http://203.255.191.229:8080/chimerdbv31/mchimerseq.cdb ChimerSeq] is a database of RNA-seq data of fusion sequences downloaded from the [https://tcga-data.nci.nih.gov/docs/publications/tcga/? TCGA data portal]. | 1 | Gene expression + Signal Transduction |
Electrometallurgy is the field concerned with the processes of metal electrodeposition. There are seven categories of these processes:
*Electrolysis
*Electrowinning, the extraction of metal from ores
*Electrorefining, the purification of metals. Metal powder production by electrodeposition is included in this category, or sometimes electrowinning, or a separate category depending on application.
*Electroplating, the deposition of a layer of one metal on another
*Electroforming, the manufacture of, usually thin, metal parts through electroplating
*Electropolishing, the removal of material from a metallic workpiece
*Etching, industrially known to Wikipedia as chemical milling | 0 | Metallurgy |
The bacterial, archaeal and plant plastid code (translation table 11) is the DNA code used by bacteria, archaea, prokaryotic viruses and chloroplast proteins. It is essentially the same as the standard code, however there are some variations in alternative start codons. | 1 | Gene expression + Signal Transduction |
Gene regulatory networks are generally thought to be made up of a few highly connected nodes (hubs) and many poorly connected nodes nested within a hierarchical regulatory regime. Thus gene regulatory networks approximate a hierarchical scale free network topology. This is consistent with the view that most genes have limited pleiotropy and operate within regulatory modules. This structure is thought to evolve due to the preferential attachment of duplicated genes to more highly connected genes. Recent work has also shown that natural selection tends to favor networks with sparse connectivity.
There are primarily two ways that networks can evolve, both of which can occur simultaneously. The first is that network topology can be changed by the addition or subtraction of nodes (genes) or parts of the network (modules) may be expressed in different contexts. The Drosophila Hippo signaling pathway provides a good example. The Hippo signaling pathway controls both mitotic growth and post-mitotic cellular differentiation. Recently it was found that the network the Hippo signaling pathway operates in differs between these two functions which in turn changes the behavior of the Hippo signaling pathway. This suggests that the Hippo signaling pathway operates as a conserved regulatory module that can be used for multiple functions depending on context. Thus, changing network topology can allow a conserved module to serve multiple functions and alter the final output of the network. The second way networks can evolve is by changing the strength of interactions between nodes, such as how strongly a transcription factor may bind to a cis-regulatory element. Such variation in strength of network edges has been shown to underlie between species variation in vulva cell fate patterning of Caenorhabditis worms. | 1 | Gene expression + Signal Transduction |
Quorum sensing has been engineered using synthetic biological circuits in different systems. Examples include rewiring the AHL components to toxic genes to control population size in bacteria; and constructing an auxin-based system to control population density in mammalian cells. Synthetic quorum sensing circuits have been proposed to enable applications like controlling biofilms or enabling drug delivery. Quorum sensing based genetic circuits have been used to convert AI-2 signals to AI-1 and then subsequently use the AI-1 signal to alter bacterial growth rate, thereby changing the composition of a consortium. | 1 | Gene expression + Signal Transduction |
Communist party Chairman Mao Zedong disdained the cities and put his faith in the Chinese peasantry for a Great Leap Forward. Mao saw steel production as the key to overnight economic modernization, promising that within 15 years China's steel production would surpass that of Britain. In 1958 he decided that steel production would double within the year, using backyard steel furnaces run by inexperienced peasants. The plan was a fiasco, as the small amounts of steel produced were of very poor quality, and the diversion of resources out of agriculture produced a massive famine in 1959–61 that killed millions.
With economic reforms brought in by Deng Xiaoping, who led China from 1978 to 1992, China began to develop a modern steel industry by building new steel plants and recycling scrap metal from the United States and Europe. As of 2013 China produced 779 million metric tons of steel each year, making it by far the largest steel producing country in the world. This is compared to 165 for the European Union, 110 for Japan, 87 for the United States and 81 for India. China's 2013 steel production was equivalent to an average of 3.14 cubic meters of steel per second. | 0 | Metallurgy |
*[http://www.efunda.com/ Diffusion Treatment Hardening]. eFunda. Retrieved 19 April 2008.
*[http://steel.keytometals.com Surface Hardening of Steels]. Key to Metals. Retrieved 19 April 2008. | 0 | Metallurgy |
Due to its involvement in cancer development, inhibition of β-catenin continues to receive significant attention. But the targeting of the binding site on its armadillo domain is not the simplest task, due to its extensive and relatively flat surface. However, for an efficient inhibition, binding to smaller "hotspots" of this surface is sufficient. This way, a "stapled" helical peptide derived from the natural β-catenin binding motif found in LEF1 was sufficient for the complete inhibition of β-catenin dependent transcription. Recently, several small-molecule compounds have also been developed to target the same, highly positively charged area of the ARM domain (CGP049090, PKF118-310, PKF115-584 and ZTM000990). In addition, β-catenin levels can also be influenced by targeting upstream components of the Wnt pathway as well as the β-catenin destruction complex. The additional N-terminal binding pocket is also important for Wnt target gene activation (required for BCL9 recruitment). This site of the ARM domain can be pharmacologically targeted by carnosic acid, for example. That "auxiliary" site is another attractive target for drug development. Despite intensive preclinical research, no β-catenin inhibitors are available as therapeutic agents yet. However, its function can be further examined by siRNA knockdown based on an independent validation. Another therapeutic approach for reducing β-catenin nuclear accumulation is via the inhibition of galectin-3. The galectin-3 inhibitor GR-MD-02 is currently undergoing clinical trials in combination with the FDA-approved dose of ipilimumab in patients who have advanced melanoma. The proteins BCL9 and BCL9L have been proposed as therapeutic targets for colorectal cancers which present hyper-activated Wnt signaling, because their deletion does not perturb normal homeostasis but strongly affects metastases behaviour. | 1 | Gene expression + Signal Transduction |
Fineness of silver in Britain was traditionally expressed as the mass of silver expressed in troy ounces and pennyweights ( troy ounce) in one troy pound (12 troy ounces) of the resulting alloy. Britannia silver has a fineness of 11 ounces, 10 pennyweights, or about silver, whereas sterling silver has a fineness of 11 ounces, 2 pennyweights, or exactly silver. | 0 | Metallurgy |
The rusticle consists of up to 35% iron compounds including iron oxides, iron carbonates, and iron hydroxides. Rusticles are found in a tube shapes of iron oxides which are vertical to one another. Rusticles are found to grow at approximately a year and are most often found in areas of sunken hulls underwater.
The remainder of the structure is a complex community of symbiotic or mutualistic microbes including bacteria Halomonas titanicae and fungi that use the rusting metal as a source of food, causing microbial corrosion and collectively producing the mineral compounds that form the rusticle as waste products.
Rusticles have been found to most often be composed of iron, calcium, chloride, magnesium, silica, sodium, and sulfate while there are other chemical compositions of rusticles but in much smaller quantities. | 0 | Metallurgy |
Prickle is also known as REST/NRSF-interacting LIM domain protein, which is a putative nuclear translocation receptor. Prickle is part of the non-canonical Wnt signaling pathway that establishes planar cell polarity. A gain or loss of function of Prickle1 causes defects in the convergent extension movements of gastrulation. In epithelial cells, Prickle2 establishes and maintains cell apical/basal polarity. Prickle1 plays an important role in the development of the nervous system by regulating the movement of nerve cells.
The first prickle protein was identified in Drosophila as a planar cell polarity protein. Vertebrate prickle-1 was first found as a rat protein that binds to a transcription factor, neuron-restrictive silencer factor (NRSF). It was then recognized that other vertebrates including mice and humans have two genes that are related to Drosophila prickle. Mouse prickle-2 was found to be expressed in mature neurons of the brain along with mouse homologs of Drosophila planar polarity genes flamingo and dischevelled. Prickle interacts with flamingo to regulate sensory axon advance at the transition between the peripheral nervous system and the central nervous system. Also, Prickle1 interacts with RE1-silencing transcription factor (REST) by transporting REST out of the nucleus. REST turns off several critical genes in neurons by binding to particular regions of DNA in the nucleus.
Prickle is recruited to the cell surface membrane by strabismus, another planar cell polarity protein. In the developing Drosophila wing, prickle becomes concentrated at the proximal side of cells. Prickle can compete with the ankyrin-repeat protein Diego for a binding site on Dishevelled.
In Drosophila, prickle is present inside cells in multiple forms due to alternative splicing of the prickle mRNA. The relative levels of the alternate forms may be regulated and involved in the normal control of planar cell polarity.
Mutations in Prickle genes can cause epilepsy in humans by perturbing Prickle function. One mutation in Prickle1 gene can result in Prickle1-Related Progressive Myoclonus Epilepsy-Ataxia Syndrome. This mutation disrupts the interaction between prickle-like 1 and REST, which results in the inability to suppress REST. Gene knockdown of Prickle1 by shRNA or dominant-negative constructs results in decreased axonal and dendritic extension in neurons in the hippocampus. Prickle1 gene knockdown in neonatal retina causes defects in axon terminals of photoreceptors and in inner and outer segments. | 1 | Gene expression + Signal Transduction |
Initiation of translation is regulated by the accessibility of ribosomes to the Shine-Dalgarno sequence. This stretch of four to nine purine residues are located upstream the initiation codon and hybridize to a pyrimidine-rich sequence near the 3 end of the 16S RNA within the 30S bacterial ribosomal subunit. Polymorphism in this particular sequence has both positive and negative effects on the efficiency of base-pairing and subsequent protein expression. Initiation is also regulated by proteins known as initiation factors which provide kinetic assistance to the binding between the initiation codon and tRNA, which supplies the 3-UAC-5' anticodon. IF1 binds the 30S subunit first, instigating a conformational change that allows for the additional binding of IF2 and IF3. IF2 ensures that tRNA remains in the correct position while IF3 proofreads initiation codon base-pairing to prevent non-canonical initiation at codons such as AUU and AUC. Generally, these initiation factors are expressed in equal proportion to ribosomes, however experiments using cold-shock conditions have shown to create stoichiometric imbalances between these translational machinery. In this case, two to three fold changes in expression of initiation factors coincide with increased favorability towards translation of specific cold-shock mRNAs. | 1 | Gene expression + Signal Transduction |
*C.F. Baes, [https://digital.library.unt.edu/ark:/67531/metadc1028644/m2/1/high_res_d/4470742.pdf The chemistry and thermodynamics of molten salt reactor fuels], Proc. AIME Nuclear Fuel Reprocessing Symposium, Ames, Iowa, USA, 1969 (August 25), | 0 | Metallurgy |
Cells in tissues need to be able to sense and interpret changes in their environment. For example, cells must be able to detect when they are in physical contact with other cells in order to regulate their growth and avoid the generation of tumors (“carcinogenesis”). In order to do so, cells place receptor molecules on their surface, often with a section of the receptor exposed to the outside of the cell (extracellular environment), and a section inside the cell (intracellular environment). These molecules are exposed to the environment outside of the cell and, therefore, in position to sense it. They are called receptors because when these come into contact with particular molecules (termed ligands), then chemical changes are induced to the receptor. These changes typically involve alterations in the three-dimensional shape of the receptor. These 3D structure changes affect both the extracellular and intracellular parts (domains) of the receptor. As a result, interaction of a receptor with its specific ligand which is located outside of the cell causes changes to the receptor part which is inside the cell. A signal from the extracellular space, therefore, can affect the biochemical state inside the cell.
Following receptor activation by the ligand, several steps can sequentially ensue. For example, the 3D shape changes to the intracellular domain may render it recognizable to catalytic proteins (enzymes) that are located inside the cell and have physical access to it. These enzymes may then induce chemical changes to the intracellular domain of the activated receptor, including the addition of phosphate chemical groups to specific components of the receptor (phosphorylation), or the physical separation (cleavage) of the intracellular domain. Such modifications may enable the intracellular domain to act as an enzyme itself, meaning that it may now catalyze the modification of other proteins in the cell. Enzymes which catalyze phosphorylation modifications are termed kinases. These modified proteins may then also be activated and enabled to induce further modifications to other proteins, and so on. This sequence of catalytic modifications is termed a “signal transduction pathway” or “second messenger cascade”. It is a critical mechanism employed by cells to sense their environment and induce complex changes to their state. Such changes may include, as noted, chemical modifications to other molecules, as well as decisions concerning which genes are activated and which are not (transcriptional regulation).
There are many signal transduction pathways in a cell and each of these involves many different proteins. This provides many opportunities for different signal transduction pathways to intercept (cross-talk). As a result, a cell simultaneously processes and interprets many different signals, as would be expected since the extracellular environment contains many different ligands. Cross-talk also allows the cell to integrate these many signals as opposed to process them independently. For example, mutually opposing signals may be activated at the same time by different ligands, and the cell can interpret these signals as a whole.
Signal transduction pathways are widely studied in biology as they provide mechanistic understanding of how a cell operates and takes critical decisions (e.g. to multiply, move, die, activate genes etc.). These pathways also provide many drug targets and are of great relevance to drug discovery efforts. | 1 | Gene expression + Signal Transduction |
Both the legacy NACE and SSPC organizations were ANSI-accredited standards developers, which AMPP plans to continue. The merged standards program includes 25 standing standards committees that develop technical standards for industries including cathodic protection, coatings, defense, highways and bridges, rail, maritime, oil and gas, power and utilities, research and testing, tanks and pipelines, and water and wastewater. | 0 | Metallurgy |
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