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Pelletizing is done in a pellet mill, where feed is normally conditioned and thermal-treated in the fitted conditioners of a pellet mill. The feed is then pushed through the holes and exit the pellet mill as pelleted feed. | 8 | Metallurgy |
Extrema of the spinodal in a temperature vs composition plot coincide with those of the binodal curve, and are known as critical points. | 7 | Physical Chemistry |
*Transport is proportional to applied bias (resistor)
*Transport can be made to move in one direction (diode)
*Control of gain is possible by introduction of third pole (transistor)
*Control of the forward/reverse direction by asymmetric gates (Field-effect reconfigurable diode) | 7 | Physical Chemistry |
The different biomolecules that make up a plant's biogenic substances – particularly those in seed exudates - can be identified by using different varieties of chromatography in a lab environment. For metabolite profiling, gas chromatography-mass spectrometry is used to find flavonoids such as quercetin. Compounds can then be further differentiated using reversed-phase high-performance liquid chromatography-mass spectrometry.
When it comes to measuring biogenic substances in a natural environment such as a body of water, a hydroecological CNPSi model can be used to calculate the spatial transport of biogenic substances, in both the horizontal and vertical dimensions. This model takes into account the water exchange and flow rate, and yields the values of biogenic substance rates for any area or layer of the water for any month. There are two main evaluation methods involved: measuring per unit water volume (mg/m year) and measuring substances per entire water volume of layer (t of element/year). The former is mostly used to observe biogenic substance dynamics and individual pathways for flux and transformations, and is useful when comparing individual regions of the strait or waterway. The second method is used for monthly substance fluxes and must take into account that there are monthly variations in the water volume in the layers.
In the study of geochemistry, biogenic substances can be isolated from fossils and sediments through a process of scraping and crushing the target rock sample, then washing with 40% hydrofluoric acid, water, and benzene/methanol in the ratio 3:1. Following this, the rock pieces are ground and centrifuged to produce a residue. Chemical compounds are then derived through various chromatography and mass spectrometry separations. However, extraction should be accompanied by rigorous precautions to ensure there is no amino acid contaminants from fingerprints, or silicone contaminants from other analytical treatment methods. | 0 | Organic Chemistry |
Cycling probe technology makes use of a chimeric nucleic acid probe to detect the presence of a particular DNA sequence. The chimeric probe consists of an RNA segment sandwiched between two DNA segments. The RNA segment contains 4 contiguous purine nucleotides. The probes should be less than 30 nucleotides in length and designed to minimize intra-probe and inter-probe interactions. | 1 | Biochemistry |
In eukaryotic cells the pyruvate decarboxylation occurs inside the mitochondrial matrix, after transport of the substrate, pyruvate, from the cytosol. The transport of pyruvate into the mitochondria is via the transport protein pyruvate translocase. Pyruvate translocase transports pyruvate in a symport fashion with a proton (across the inner mitochondrial membrane), which may be considered to be a form of secondary active transport, but further confirmation/support may be needed for the usage of "secondary active transport" desciptor here (Note: the pyruvate transportation method via the pyruvate translocase appears to be coupled to a proton gradient according to S. Papa et al., 1971, seemingly matching secondary active transport in definition).
Alternative sources say "transport of pyruvate across the outer mitochondrial membrane appears to be easily accomplished via large non-selective channels such as voltage-dependent anion channels, which enable passive diffusion" and transport across inner mitochondrial membrane is mediated by mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2).
Upon entry into the mitochondrial matrix, the pyruvate is decarboxylated, producing acetyl-CoA (and carbon dioxide and NADH). This irreversible reaction traps the acetyl-CoA within the mitochondria (the acetyl-CoA can only be transported out of the mitochondrial matrix under conditions of high oxaloacetate via the citrate shuttle, a TCA intermediate that is normally sparse). The carbon dioxide produced by this reaction is nonpolar and small, and can diffuse out of the mitochondria and out of the cell.
In prokaryotes, which have no mitochondria, this reaction is either carried out in the cytosol, or not at all. | 1 | Biochemistry |
Nowadays, most radical photopolymerization pathways are based on addition reactions of carbon double bonds in acrylates or methacrylates, and these pathways are widely employed in photolithography and stereolithography.
Before the free radical nature of certain polymerizations was determined, certain monomers were observed to polymerize when exposed to light. The first to demonstrate the photoinduced free radical chain reaction of vinyl bromide was Ivan Ostromislensky, a Russian chemist who also studied the polymerization of synthetic rubber. Subsequently, many compounds were found to become dissociated by light and found immediate use as photoinitiators in the polymerization industry.
In the free radical mechanism of radiation curable systems, light absorbed by a photoinitiator generates free-radicals which induce cross-linking reactions of a mixture of functionalized oligomers and monomers to generate the cured film
Photocurable materials that form through the free-radical mechanism undergo chain-growth polymerization, which includes three basic steps: initiation, chain propagation, and chain termination. The three steps are depicted in the scheme below, where R• represents the radical that forms upon interaction with radiation during initiation, and M is a monomer. The active monomer that is formed is then propagated to create growing polymeric chain radicals. In photocurable materials the propagation step involves reactions of the chain radicals with reactive double bonds of the prepolymers or oligomers. The termination reaction usually proceeds through combination, in which two chain radicals are joined, or through disproportionation, which occurs when an atom (typically hydrogen) is transferred from one radical chain to another resulting in two polymeric chains.
;Initiation
;Propagation
;Termination
:combination
:disproportionation
Most composites that cure through radical chain growth contain a diverse mixture of oligomers and monomers with functionality that can range from 2-8 and molecular weights from 500 to 3000. In general, monomers with higher functionality result in a tighter crosslinking density of the finished material. Typically these oligomers and monomers alone do not absorb sufficient energy for the commercial light sources used, therefore photoinitiators are included. | 5 | Photochemistry |
Bioenergetics is the part of biochemistry concerned with the energy involved in making and breaking of chemical bonds in the molecules found in biological organisms. It can also be defined as the study of energy relationships and energy transformations and transductions in living organisms. The ability to harness energy from a variety of metabolic pathways is a property of all living organisms. Growth, development, anabolism and catabolism are some of the central processes in the study of biological organisms, because the role of energy is fundamental to such biological processes. Life is dependent on energy transformations; living organisms survive because of exchange of energy between living tissues/ cells and the outside environment. Some organisms, such as autotrophs, can acquire energy from sunlight (through photosynthesis) without needing to consume nutrients and break them down. Other organisms, like heterotrophs, must intake nutrients from food to be able to sustain energy by breaking down chemical bonds in nutrients during metabolic processes such as glycolysis and the citric acid cycle. Importantly, as a direct consequence of the First Law of Thermodynamics, autotrophs and heterotrophs participate in a universal metabolic network—by eating autotrophs (plants), heterotrophs harness energy that was initially transformed by the plants during photosynthesis.
In a living organism, chemical bonds are broken and made as part of the exchange and transformation of energy. Energy is available for work (such as mechanical work) or for other processes (such as chemical synthesis and anabolic processes in growth), when weak bonds are broken and stronger bonds are made. The production of stronger bonds allows release of usable energy.
Adenosine triphosphate (ATP) is the main "energy currency" for organisms; the goal of metabolic and catabolic processes are to synthesize ATP from available starting materials (from the environment), and to break- down ATP (into adenosine diphosphate (ADP) and inorganic phosphate) by utilizing it in biological processes. In a cell, the ratio of ATP to ADP concentrations is known as the "energy charge" of the cell. A cell can use this energy charge to relay information about cellular needs; if there is more ATP than ADP available, the cell can use ATP to do work, but if there is more ADP than ATP available, the cell must synthesize ATP via oxidative phosphorylation.
Living organisms produce ATP from energy sources via oxidative phosphorylation. The terminal phosphate bonds of ATP are relatively weak compared with the stronger bonds formed when ATP is hydrolyzed (broken down by water) to adenosine diphosphate and inorganic phosphate. Here it is the thermodynamically favorable free energy of hydrolysis that results in energy release; the phosphoanhydride bond between the terminal phosphate group and the rest of the ATP molecule does not itself contain this energy. An organism's stockpile of ATP is used as a battery to store energy in cells. Utilization of chemical energy from such molecular bond rearrangement powers biological processes in every biological organism.
Living organisms obtain energy from organic and inorganic materials; i.e. ATP can be synthesized from a variety of biochemical precursors. For example, lithotrophs can oxidize minerals such as nitrates or forms of sulfur, such as elemental sulfur, sulfites, and hydrogen sulfide to produce ATP. In photosynthesis, autotrophs produce ATP using light energy, whereas heterotrophs must consume organic compounds, mostly including carbohydrates, fats, and proteins. The amount of energy actually obtained by the organism is lower than the amount present in the food; there are losses in digestion, metabolism, and thermogenesis.
Environmental materials that an organism intakes are generally combined with oxygen to release energy, although some nutrients can also be oxidized anaerobically by various organisms. The utilization of these materials is a form of slow combustion because the nutrients are reacted with oxygen (the materials are oxidized slowly enough that the organisms do not produce fire). The oxidation releases energy, which may evolve as heat or be used by the organism for other purposes, such as breaking chemical bonds. | 1 | Biochemistry |
At slow scan rates there should be no separation between the oxidative and reductive peaks.
* A one-electron site (e.g. a heme or FeS cluster) gives a broad peak (fig 1A). The equation that gives the shape and intensity of the peak is:
: Ideally, the peak position is in both directions. The peak current is (it is proportional to scan rate, , and to the amount of redox sites on the electrode, ). The ideal half width at half height (HWHH) equates mV at 20 °C. Non-ideal behaviour may result in the peak being broader than the ideal limit.
* The peak shape for a two-electron redox site (e.g. a flavin) depends on the stability of the half-reduced state (fig 1B). If the half-reduced state is stable over a large range of electrode potential, the signal is the sum of two one-electron peaks (purple line in fig 1B). If the half reduced state is unstable, the signal is a single peak (red line in fig 1B), which may have up to four times the height and half the width of a one-electron peak.
* A protein that contains multiple redox centers should give multiple peaks which all have the same area (scaled by ). | 7 | Physical Chemistry |
While FeAl is a B2 alloy, the observed yield strength anomaly in FeAl is due to another mechanism. If cross-slip were the mechanism, then the yield strength anomaly would be rate dependent, as expected for a thermally activated process. Instead, yield strength anomaly is state dependent, which is a property that is dependent on the state of the material. As a result, vacancy activated strengthening is the most widely-accepted mechanism. The vacancy formation energy is low for FeAl, allowing for an unusually high concentration of vacancies in FeAl at high temperatures (2.5% at 1000C for Fe-50Al). The vacancy formed in either aluminum-rich FeAl or through heating is an aluminum vacancy.
At low temperatures around 300K, the yield strength either decreases or does not change with temperature. At moderate temperatures (0.35-0.45 T), yield strength has been observed to increase with an increased vacancy concentration, providing further evidence for a vacancy driven strengthening mechanism. The increase in yield strength from increased vacancy concentration is believed to be the result of dislocations being pinned by vacancies on the slip plane, causing the dislocations to bow. Then, above the peak stress temperature, vacancies can migrate as vacancy migration is easier with elevated temperatures. At those temperatures, vacancies no longer hinder dislocation motion but rather aid climb. In the vacancy strengthening model, the increased strength below the peak stress temperature is approximated as proportional to the vacancy concentration to the one-half with the vacancy concentration estimated using Maxwell-Boltzmann statistics. Thus, the strength can be estimated as , with being the vacancy formation energy and T being the absolute temperature. Above the peak stress temperature, a diffusion-assisted deformation mechanism can be used to describe strength since vacancies are now mobile and assist dislocation motion. Above the peak, the yield strength is strain rate dependent and thus, the peak yield strength is rate dependent. As a result, the peak stress temperature increases with an increased strain rate. Note, this is different than the yield strength anomaly, which is the yield strength below the peak, being rate dependent. The peak yield strength is also dependent on percent aluminum in the FeAl alloy. As the percent aluminum increases, the peak yield strength occurs at lower temperatures.
The yield strength anomaly in FeAl alloys can be hidden if thermal vacancies are not minimized through a slow anneal at a relatively low temperature (~400 °C for ~5 days). Further, the yield strength anomaly is not present in systems that use a very low strain rate as the peak yield strength is strain rate dependent and thus, would occur at temperatures too low to observe the yield strength anomaly. Additionally, since the formation of vacancies requires time, the peak yield strength magnitude is dependent on how long the material is held at the peak stress temperature. Also, the peak yield strength has been found not to be dependent on crystal orientation.
Other mechanisms have been proposed including a cross slip mechanism similar to that for L1, dislocation decomposition into less mobile segments at jogs, dislocation pinning, climb-lock mechanism, and slip vector transition. The slip vector transition from MnAl is not dependent on strain rate and thus, may not follow the vacancy activated strengthening mechanism. Instead, there an order-strengthening mechanism has been proposed. | 8 | Metallurgy |
Herbicides (, ), also commonly known as weed killers, are substances used to control undesired plants, also known as weeds. Selective herbicides control specific weed species while leaving the desired crop relatively unharmed, while non-selective herbicides (sometimes called "total weed killers") kill plants indiscriminately. The combined effects of herbicides, nitrogen fertilizer, and improved cultivars has increased yields (per acre) of major crops by 3x to 6x from 1900 to 2000.
In the United States in 2012, about 91% of all herbicide usage, determined by weight applied, was in agriculture. In 2012, world pesticide expenditures totaled nearly $24.7 billion; herbicides were about 44% of those sales and constituted the biggest portion, followed by insecticides, fungicides, and fumigants. Herbicide is also used in forestry, where certain formulations have been found to suppress hardwood varieties in favor of conifers after clearcutting, as well as pasture systems. | 2 | Environmental Chemistry |
Exfoliation (or onion skin weathering) is the gradual removing of spall due to the cyclic increase and decrease in the temperature of the surface layers of the rock. Rocks do not conduct heat well, so when they are exposed to extreme heat, the outermost layer becomes much hotter than the rock underneath causing differential thermal expansion. This differential expansion causes sub-surface shear stress, in turn causing spalling. Extreme temperature change, such as forest fires, can also cause spalling of rock. This mechanism of weathering causes the outer surface of the rock to fall off in thin fragments, sheets or flakes, hence the name exfoliation or onion skin weathering. | 8 | Metallurgy |
Copper is a biologically important metal to detect. It has many sensors developed for it including:
*CTAP-1, a sensor that shows a response in the UV region when Cu(I) binds to an azatetrathiacrown motif that in turn excites a pyrazoline-based dye that is attached. To use the probe, one excites it at 365 nm. If it is bound to Cu, then it will increase its fluorescence intensity. CTAP-1 is effective as it has a large modulation in its spectrum upon binding Cu, and is selective for the binding of Cu over other metals.
*Coppersensor-1 (CS1) that comprises a thioether rich motif that binds to Cu(I) causing the excitation of a boron-dipyrromethene (BODIPY) dye in the visible region. The probe has good selectivity for Cu(I) over alkaline earth metals, Cu(II), and d-block metals. | 5 | Photochemistry |
The Intronerator is a database of alternatively spliced genes and a database of introns for Caenorhabditis elegans. | 1 | Biochemistry |
PCET is thought to be pervasive. Important examples include water oxidation in photosynthesis, nitrogen fixation, oxygen reduction reaction, and the function of hydrogenases. These processes are relevant to respiration. | 7 | Physical Chemistry |
pRb has also been implicated in regulating metabolism through interactions with components of cellular metabolic pathways. RB1 mutations can cause alterations in metabolism, including reduced mitochondrial respiration, reduced activity in the electron transport chain, and changes in flux of glucose and/or glutamine. Particular forms of pRb have been found to localize to the outer mitochondrial membrane and directly interacts with Bax to promote apoptosis. | 1 | Biochemistry |
Myzocytosis (from Greek: myzein, () meaning "to suck" and kytos () meaning "container", hence referring to "cell") is a method of feeding found in some heterotrophic organisms. It is also called "cellular vampirism" as the predatory cell pierces the cell wall and/or cell membrane of the prey cell with a feeding tube, the conoid, sucks out the cellular content and digests it.
Myzocytosis is found in Myzozoa and also in some species of Ciliophora (both comprise the alveolates). A classic example of myzocytosis is the feeding method of the infamous predatory ciliate, Didinium, where it is often depicted devouring a hapless Paramecium. The suctorian ciliates were originally thought to have fed exclusively through myzocytosis, sucking out the cytoplasm of prey via superficially drinking straw-like pseudopodia. It is now understood that suctorians do not feed through myzocytosis, but actually, instead, manipulate and envenomate captured prey with their tentacle-like pseudopodia. | 1 | Biochemistry |
The presence of nitrogen activates the csiR gene located downstream of the gabP gene. The csiR gene encodes a protein that acts as a transcriptional repressor for csiD-ygaF-gab operon hence shutting off the GABA degradation pathway. | 1 | Biochemistry |
Macrophages and related cells employ a different mechanism to recognize the pathogen. Their receptors recognize certain motifs present on the invading pathogen that are very unlikely to be present on a host cell. Such repeating motifs are recognized by pattern recognition receptors (PRRs) like the toll-like receptors (TLRs) expressed by the macrophages. Since the same receptor could bind to a given motif present on surfaces of widely disparate microorganisms, this mode of recognition is relatively nonspecific, and constitutes an innate immune response. | 1 | Biochemistry |
In a small number of cases, plant genes are effective against an entire pathogen species, even though that species is pathogenic on other genotypes of that host species. Examples include barley MLO against powdery mildew, wheat Lr34 against leaf rust and wheat Yr36 against wheat stripe rust. An array of mechanisms for this type of resistance may exist depending on the particular gene and plant-pathogen combination. Other reasons for effective plant immunity can include a lack of coadaptation (the pathogen and/or plant lack multiple mechanisms needed for colonization and growth within that host species), or a particularly effective suite of pre-formed defenses. | 1 | Biochemistry |
The first heteropoly molybdate and first heteropolymetallate, yellow ammonium phosphomolybdate, (NH)PMoO was discovered by Berzelius in 1826. The phosphorus atom in the anion is termed the heteroatom, other heteroatoms are silicon and arsenic. The heteropoly-molybdenum blues have structures based on the Keggin structure. The blue colour arises because the near-colourless anion, such as the phosphomolybdate anion, , can accept more electrons (i.e. be reduced) to form an intensely coloured mixed-valence complex. This can occur in one electron or two electron steps. The reduction process is reversible and the structure of the anion is essentially unchanged.
: PMo + 4 e ⇌ PMoMo
The structure of the anion, PMoMo, has been determined in the solid state and is a β-isomer (i.e. with one of the four groups of edge-shared octahedra on the α-Keggin ion rotated through 60°). Similar structures have been found with silicon, germanium or arsenic heteroatoms.
The intense blue colour of the reduced anion is the basis for the use of heteropoly-molybdenum blues in quantitative and qualitative analytical techniques.
This property is exploited as follows:
*the sample to be analysed is reacted to produce the reduced blue heteropoly-molybdate in order to:
**detect the presence of a hetero atom in e.g. a spot test
** measure the amount of a hetero atom present in the sample colorimetrically
*the sample is added to a solution of the near colourless, unreduced complex in order to:
**detect the presence of a reducing compound e.g. a reducing sugar such as glucose
**measure the amount of a reducing compound in a two step procedure | 7 | Physical Chemistry |
Phosphoric acid units can be bonded together in rings (cyclic structures). The simplest such compound is trimetaphosphoric acid or cyclo-triphosphoric acid having the formula . Its structure is shown in the illustration. Since the ends are condensed, its formula has one less (water) than tripolyphosphoric acid.
The general formula of a phosphoric acid is , where n is the number of phosphorus atoms and x is the number of fundamental cycles in the molecule's structure; that is, the minimum number of bonds that would have to be broken to eliminate all cycles.
The limiting case of internal condensation, where all oxygen atoms are shared and there are no hydrogen atoms (x = ) is an anhydride , phosphorus pentoxide . | 0 | Organic Chemistry |
Brown MX-5BR or Reactive Brown 10 has a formula of CHClCrNNaOS and a molecular weight of 1163.6 g/mol, containing two dichlorotriazine rings. Brown MX-5BR, for example, can be used to purify lysozyme, phosphinothricin acetyltransferase. It also shown that it can elute tryptophanyl-tRNA synthetase using Trp as eluant, however, tryptophanyl-tRNA and tyrosyl-tRNA synthetase are the only t-RNA that can be elute out using Brown MX-5BR. | 3 | Analytical Chemistry |
Metallization pressure is the pressure required for a non-metallic chemical element to become a metal. Every material is predicted to turn into a metal if the pressure is high enough, and temperature low enough. Some of these pressures are beyond the reach of diamond anvil cells, and are thus theoretical predictions. Neon has the highest metallization pressure for any element.
The value for phosphorus refers to pressurizing black phosphorus. The value for arsenic refers to pressurizing metastable black arsenic; grey arsenic, the standard state, is already a metallic conductor at standard conditions. No value is known or theoretically predicted for radon. | 7 | Physical Chemistry |
Based on atomicity, molecules can be classified as:
*Monoatomic (composed of one atom). Examples include He (helium), Ne (neon), Ar (argon), and Kr (krypton). All noble gases are monoatomic.
* Diatomic (composed of two atoms). Examples include H (hydrogen), N (nitrogen), O (oxygen), F (fluorine), and Cl (chlorine). Halogens are usually diatomic.
*Triatomic (composed of three atoms). Examples include O (ozone).
*Polyatomic (composed of three or more atoms). Examples include S.
Atomicity may vary in different allotropes of the same element.
The exact atomicity of metals, as well as some other elements such as carbon, cannot be determined because they consist of a large and indefinite number of atoms bonded together. They are typically designated as having an atomicity of 1.
The atomicity of homonuclear molecule can be derived by dividing the molecular weight by the atomic weight. For example, the molecular weight of oxygen is 31.999, while its atomic weight is 15.879; therefore, its atomicity is approximately 2 (31.999/15.879 ≈ 2). | 7 | Physical Chemistry |
Reinhold and coworkers performed a systematical experiment to study the kinetics and mechanisms of hydrolysis of such compounds. They prepared a series of α-silanes and γ-silanes and tested their reactivity in different pH (acidic and basic regime), functional group X and the spacer
between the silicon atom and the functional group X.
In general, they find that under basic conditions, the rate of hydrolysis is mainly controlled by the electrophilicity of the silicon center and the rate of the hydrolysis of the γ-silanes is less influenced by the generally electronegative functional groups than α-silanes. More electronegative the functional groups are, the higher the rate of hydrolysis. However, under acidic conditions, the rate of hydrolysis depends on both the electrophilicity of the silicon center (determining the molecular reactivity) and the concentration of the (protonated) reactive species. Under acidic conditions, the nucleophile changes from OH to HO, so it involves the process of protonation and the atoms are protonated could be either silicon or the functional group X. As a result, the general trend in acidic solution is more complicated. | 7 | Physical Chemistry |
Solid phosphorus pentachloride is an ionic compound, formulated , that is, a salt containing the tetrachlorophosphonium cation. Dilute solutions dissociate according to the following equilibrium:
:PCl + Cl
Triphenylphosphine dichloride (PhPCl) exists both as the pentacoordinate phosphorane and as the chlorotriphenylphosphonium chloride, depending on the medium. The situation is similar to that of PCl. It is an ionic compound (PPhCl)Cl in polar solutions and a molecular species with trigonal bipyramidal molecular geometry in apolar solution. | 0 | Organic Chemistry |
In SEC, mass is not measured so much as the hydrodynamic volume of the polymer molecules, that is, how much space a particular polymer molecule takes up when it is in solution. However, the approximate molecular weight can be calculated from SEC data because the exact relationship between molecular weight and hydrodynamic volume for polystyrene can be found. For this, polystyrene is used as a standard. But the relationship between hydrodynamic volume and molecular weight is not the same for all polymers, so only an approximate measurement can be obtained.
Another drawback is the possibility of interaction between the stationary phase and the analyte. Any interaction leads to a later elution time and thus mimics a smaller analyte size.
When performing this method, the bands of the eluting molecules may be broadened. This can occur by turbulence caused by the flow of the mobile phase molecules passing through the molecules of the stationary phase. In addition, molecular thermal diffusion and friction between the molecules of the glass walls and the molecules of the eluent contribute to the broadening of the bands. Besides broadening, the bands also overlap with each other. As a result, the eluent usually gets considerably diluted. A few precautions can be taken to prevent the likelihood of the bands broadening. For instance, one can apply the sample in a narrow, highly concentrated band on the top of the column. The more concentrated the eluent is, the more efficient the procedure would be. However, it is not always possible to concentrate the eluent, which can be considered as one more disadvantage. | 1 | Biochemistry |
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. They are coupled with G proteins. They pass through the cell membrane seven times in the form of six loops (three extracellular loops interacting with ligand molecules, three intracellular loops interacting with G proteins, an N-terminal extracellular region and a C-terminal intracellular region) of amino acid residues, which is why they are sometimes referred to as seven-transmembrane receptors. Ligands can bind either to the extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within transmembrane helices (rhodopsin-like family). They are all activated by agonists, although a spontaneous auto-activation of an empty receptor has also been observed.
G protein-coupled receptors are found only in eukaryotes, including yeast, and choanoflagellates. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases.
There are two principal signal transduction pathways involving the G protein-coupled receptors:
*the cAMP signal pathway and
*the phosphatidylinositol signal pathway.
When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (G, G, G, G).
GPCRs are an important drug target and approximately 34% of all Food and Drug Administration (FDA) approved drugs target 108 members of this family. The global sales volume for these drugs is estimated to be 180 billion US dollars . It is estimated that GPCRs are targets for about 50% of drugs currently on the market, mainly due to their involvement in signaling pathways related to many diseases i.e. mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. The long ago discovered association between GPCRs and many endogenous and exogenous substances, resulting in e.g. analgesia, is another dynamically developing field of the pharmaceutical research. | 1 | Biochemistry |
The transformation that converts 7-dehydrocholesterol to vitamin D occurs in two steps. First, 7-dehydrocholesterol is photolyzed by ultraviolet light in a 6-electron conrotatory ring-opening electrocyclic reaction; the product is previtaminD. Second, previtaminD spontaneously isomerizes to vitaminD (cholecalciferol) in an antarafacial [[Sigmatropic shift#.5B1,7.5D Shifts|sigmatropic [1,7] hydride shift]]. At room temperature, the transformation of previtaminD to vitamin D in an organic solvent takes about 12 days to complete. The conversion of previtaminD to vitamin D in the skin is about 10 times faster than in an organic solvent.
The conversion from ergosterol to vitamin D follows a similar procedure, forming previtaminD by photolysis, which isomerizes to vitamin D (ergocalciferol). The transformation of previtaminD to vitamin D in methanol has a rate comparable to that of previtaminD. The process is faster in white button mushrooms. | 1 | Biochemistry |
TFH participates in nucleotide excision repair (NER) by opening the DNA double helix after damage is initially recognized. NER is a multi-step pathway that removes a wide range of different damages that distort normal base pairing, including bulky chemical damages and UV-induced damages. Individuals with mutational defects in genes specifying protein components that catalyze the NER pathway, including the TFH components, often display features of premature aging (see DNA damage theory of aging). | 1 | Biochemistry |
In chemistry, a phosphoric acid, in the general sense, is a phosphorus oxoacid in which each phosphorus (P) atom is in the oxidation state +5, and is bonded to four oxygen (O) atoms, one of them through a double bond, arranged as the corners of a tetrahedron. Two or more of these tetrahedra may be connected by shared single-bonded oxygens, forming linear or branched chains, cycles, or more complex structures. The single-bonded oxygen atoms that are not shared are completed with acidic hydrogen atoms. The general formula of a phosphoric acid is , where n is the number of phosphorus atoms and x is the number of fundamental cycles in the molecule's structure, between 0 and .
Removal of protons () from k hydroxyl groups –OH leaves anions generically called phosphates (if ) or hydrogen phosphates (if k is between 1 and ), with general formula . The fully dissociated anion () has formula . The term phosphate is also used in organic chemistry for the functional groups that result when one or more of the hydrogens are replaced by bonds to other groups.
These acids, together with their salts and esters, include some of the best-known compounds of phosphorus, of high importance in biochemistry, mineralogy, agriculture, pharmacy, chemical industry, and chemical research. | 0 | Organic Chemistry |
Jonathan David Sarfati (born 1 October 1964) is a young Earth creationist who writes articles for Creation Ministries International (CMI), a non-profit Christian apologetics ministry. Sarfati has a PhD in chemistry, and was New Zealand national chess champion in 1987 and 1988. | 7 | Physical Chemistry |
Polyhydroxyalkanoates (PHA) are linear polyesters produced in nature by bacterial fermentation of sugar or lipids. They are produced by the bacteria to store carbon and energy. In industrial production, the polyester is extracted and purified from the bacteria by optimizing the conditions for the fermentation of sugar. More than 150 different monomers can be combined within this family to give materials with extremely different properties. PHA is more ductile and less elastic than other plastics, and it is also biodegradable. These plastics are being widely used in the medical industry. | 7 | Physical Chemistry |
Heme C differs from heme B in that the two vinyl side chains of heme B are replaced by covalent, thioether linkages to the apoprotein. The two thioether linkages are typically made by cysteine residues of the protein. These linkages do not allow the heme C to easily dissociate from the holoprotein, cytochrome c, compared with the more easily dissociated heme B that may dissociate from the holoprotein, the heme-protein complex, even under mild conditions. This allows a very wide range of cytochrome c structure and function, with myriad c type cytochromes acting primarily as electron carriers. The redox potential for cytochrome c can also be "fine-tuned" by small changes in protein structure and solvent interaction.
The number of heme C units bound to a holoprotein is highly variable. For vertebrate cells one heme C per protein is the rule but for bacteria this number is often 2, 4, 5, 6 or even 16 heme C groups per holoprotein. It is generally agreed the number and arrangement of heme C groups are related and even required for proper holoprotein function. For instance, those proteins containing several heme C groups are involved with multiple electron transfer reactions, particularly important is the 6 electron reduction required to reduce atmospheric nitrogen into two organic ammonia molecules. It is common for the heme C to amino acid ratio to be high for bacterial hemeproteins, so the interiors of some cytochrome c proteins appear packed with many heme C groups compared with other hemeproteins. Some hemeproteins, often from single cell organisms, may contain five hemes C. The bc complex is another important enzyme that contains a C type heme.
The thioether linkages seem to allow a great freedom of function for the holoproteins. In general, the c type cytochromes can be "fine tuned" over a wider range of oxidation-reduction potential than cytochromes b. This may be an important reason why cytochrome c is nearly ubiquitous throughout life. Heme C also plays an important role in apoptosis where just a few molecules of cytoplasmic cytochrome c, which must still contain heme C, leads to programmed cell death. Cytochrome c can be measured in human serum and can be used as a marker for inflammation.
In addition to these equatorial covalent bonds, the heme iron is also usually axially coordinated to the side chains of two amino acids, making the iron hexacoordinate. For example, mammalian and tuna cytochrome c contain a single heme C that is axially coordinated to side chains of both histidine and methionine. Perhaps because of the two covalent bonds holding the heme to the protein, the iron of heme C is sometimes axially ligated to the amino group of lysine or even water. | 1 | Biochemistry |
AuAl has low electrical conductivity and relatively low melting point. AuAl's formation at the joint causes increase of electrical resistance, which can lead to electrical failure. AuAl typically forms at 95% of Au and 5% of Al by mass, its melting point is about 575 °C, which is the lowest among the major gold-aluminum intermetallic compounds. AuAl is a bright-purple compound and a brittle, its composition is about 78.5% Au and 21.5% Al by mass. AuAl is the most thermally stable specie of the Au–Al intermetallic compounds, it has a melting point of 1060 °C (see phase diagram), which is similar to the melting point of pure gold. AuAl can react with Au, therefore is often replaced by AuAl, a tan-colored substancewhich forms at composition of 93% of Au and 7% of Al by mass. It is also a poor conductor and can cause electrical failure of the joint, which further lead to mechanical failure. | 8 | Metallurgy |
Hilbert Spectroscopy uses Hilbert transforms to analyze broad spectrum signals from gigahertz to terahertz frequency radio. One suggested use is to quickly analyze liquids inside airport passenger luggage. | 7 | Physical Chemistry |
Denaturing gels are run under conditions that disrupt the natural structure of the analyte, causing it to unfold into a linear chain. Thus, the mobility of each macromolecule depends only on its linear length and its mass-to-charge ratio. Thus, the secondary, tertiary, and quaternary levels of biomolecular structure are disrupted, leaving only the primary structure to be analyzed.
Nucleic acids are often denatured by including urea in the buffer, while proteins are denatured using sodium dodecyl sulfate, usually as part of the SDS-PAGE process. For full denaturation of proteins, it is also necessary to reduce the covalent disulfide bonds that stabilize their tertiary and quaternary structure, a method called reducing PAGE. Reducing conditions are usually maintained by the addition of beta-mercaptoethanol or dithiothreitol. For a general analysis of protein samples, reducing PAGE is the most common form of protein electrophoresis.
Denaturing conditions are necessary for proper estimation of molecular weight of RNA. RNA is able to form more intramolecular interactions than DNA which may result in change of its electrophoretic mobility. Urea, DMSO and glyoxal are the most often used denaturing agents to disrupt RNA structure. Originally, highly toxic methylmercury hydroxide was often used in denaturing RNA electrophoresis, but it may be method of choice for some samples.
Denaturing gel electrophoresis is used in the DNA and RNA banding pattern-based methods temperature gradient gel electrophoresis (TGGE) and denaturing gradient gel electrophoresis (DGGE). | 1 | Biochemistry |
HABs occur naturally off coasts all over the world. Marine dinoflagellates produce ichthyotoxins. Where HABs occur, dead fish wash up on shore for up to two weeks after a HAB has been through the area. In addition to killing fish, the toxic algae contaminate shellfish. Some mollusks are not susceptible to the toxin, and store it in their fatty tissues. By consuming the organisms responsible for HABs, shellfish can accumulate and retain saxitoxin produced by these organisms. Saxitoxin blocks sodium channels and ingestion can cause paralysis within 30 minutes.
In addition to directly harming marine animals and vegetation loss, harmful algal blooms can also lead to ocean acidification, which occurs when the amount of carbon dioxide in the water is increased to unnatural levels. Ocean acidification slows the growth of certain species of fish and shellfish, and even prevents shell formation in certain species of mollusks. These subtle, small changes can add up over time to cause chain reactions and devastating effects on whole marine ecosystems.
Other animals that eat exposed shellfish are susceptible to the neurotoxin, which may lead to neurotoxic shellfish poisoning and sometimes even death. Most mollusks and clams filter feed, which results in higher concentrations of the toxin than just drinking the water. Scaup, for example, are diving ducks whose diet mainly consists of mollusks. When scaup eat the filter-feeding shellfish that have accumulated high levels of the HAB toxin, their population becomes a prime target for poisoning. However, even birds that do not eat mollusks can be affected by simply eating dead fish on the beach or drinking the water.
The toxins released by the blooms can kill marine animals including dolphins, sea turtles, birds, and manatees. The Florida Manatee, a subspecies of the West Indian Manatee, is a species often impacted by red tide blooms. Florida manatees are often exposed to the poisonous red-tide toxins either by consumption or inhalation. There are many small barnacles, crustaceans, and other [https://edis.ifas.ufl.edu/publication/SG188 epiphytes] that grow on the blades of seagrass. These tiny creatures filter particles from the water around them and use these particles as their main food source. During red tide blooms, they also filter the toxic red tide cells from the water, which then becomes concentrated inside them. Although these toxins do not harm epiphytes, they are extremely poisonous to marine creatures who consume (or accidentally consume) the exposed epiphytes, such as manatees. When manatees unknowingly consume exposed epiphytes while grazing on sea grass, the toxins are subsequently released from the epiphytes and ingested by the manatees. In addition to consumption, manatees may also become exposed to air-borne Brevetoxins released from harmful red-tide cells when passing through algal blooms.
Manatees also have an immunoresponse to HABs and their toxins that can make them even more susceptible to other stressors. Due to this susceptibility, manatees can die from either the immediate, or the after effects of the HAB. In addition to causing manatee mortalities, red-tide exposure also causes severe [https://www.researchgate.net/publication/271274562_Sublethal_red_tide_toxin_exposure_in_free-ranging_manatees_Trichechus_manatus_affects_the_immune_system_through_reduced_lymphocyte_proliferation_responses_inflammation_and_oxidative_stress sublethal health problems among Florida manatee populations]. Studies have shown that red-tide exposure among free-ranging Florida manatees has been shown to negatively impact immune functioning by causing increased inflammation, a reduction in lymphocyte proliferation responses, and oxidative stress.
Fish such as Atlantic herring, American pollock, winter flounder, Atlantic salmon, and cod were dosed orally with these toxins in an experiment, and within minutes the subjects started to exhibit a loss of equilibrium and began to swim in an irregular, jerking pattern, followed by paralysis and shallow, arrhythmic breathing and eventually death, after about an hour. HABs have been shown to have a negative effect also in the memory functions of sea lions. | 3 | Analytical Chemistry |
Palladacycles are used as pre-catalysts, usually by the reductive elimination from palladium(II) to the catalytically active palladium(0). In the example of 2-aminobiphenyl palladacycles, a kinetically active 12-electrons Pd(0) species is formed, allowing for further oxidative addition with reactants. A series of 2-aminobiphenyl bearing various X and L groups were synthesized to better understand the electron/steric effect.
By employing palladacycles as pre-catalysts, high reactivity and selectivity have been achieved in Heck reaction[2] and a variety of cross-coupling reactions, such as Suzuki, Sonogashira, Stille, Buchwald–Hartwig reactions.
Total synthesis containing palladacycles have been demonstrated. | 0 | Organic Chemistry |
While the aggregates can explain much of the protein fouling found in milk processing, this does not account for it all. A third type of fouling has been discovered that is explained by the chemical interactions of the denatured β-lg proteins.
β-lg contains 5 cysteine residues, four of which are covalently bonded to each other, forming an S-S bond. When β-lg is denatured, the fifth cysteine residue is exposed to the water. This residue then bonds to other β-lg proteins, including those already adsorbed to the surface. This produces a strong interaction between the denatured proteins and the surface of the container. | 1 | Biochemistry |
In 2005 there were "several types of commercial cyclic olefin copolymers based on different types of cyclic monomers and polymerization methods. Cyclic olefin copolymers are produced by chain copolymerization of cyclic monomers such as 8,9,10-trinorborn-2-ene (norbornene) or 1,2,3,4,4a,5,8,8a-octahydro-1,4:5,8-dimethanonaphthalene (tetracyclododecene) with ethene (such as Polyplastics subsidiary TOPAS Advanced Polymers TOPAS, Mitsui Chemicals APEL), or by ring-opening metathesis polymerization of various cyclic monomers followed by hydrogenation (Japan Synthetic Rubbers ARTON, Zeon Chemicals Zeonex and Zeonor)." These later materials using a single type of monomer are more properly named cyclic olefin polymers (COP). | 7 | Physical Chemistry |
A rezas crystallization depends on the time it takes for layers of its chains to fold and orient themselves in the same direction. This time increases with a molecules weight and branching. The table below shows that the growth rate is higher for Sclair 14B.1 than Sclair 2907 (20%), where 2907 is less highly branched than 14B.1. Here Gc is the crystal growth rate, or how quickly it orders itself depending on the layers, and t is the time it takes to order. | 7 | Physical Chemistry |
The photodegradation of pesticides is of great interest because of the scale of agriculture and the intensive use of chemicals. Pesticides are however selected in part not to photodegrade readily in sunlight in order to allow them to exert their biocidal activity. Thus, more modalities are implemented to enhance their photodegradation, including the use of photosensitizers, photocatalysts (e.g., titanium dioxide), and the addition of reagents such as hydrogen peroxide that would generate hydroxyl radicals that would attack the pesticides. | 5 | Photochemistry |
The Reststrahlen effect (German: “residual rays”) is a reflectance phenomenon in which electromagnetic radiation within a narrow energy band cannot propagate within a given medium due to a change in refractive index concurrent with the specific absorbance band of the medium in question; this narrow energy band is termed the Reststrahlen band.
As a result of this inability to propagate, normally incident Reststrahlen band radiation experiences strong-reflection or total-reflection from that medium. The energies at which Reststrahlen bands occur vary and are particular to the individual compound. Numerous physical attributes of a compound will have an effect on the appearance of the Reststrahlen band. These include phonon band-gap, particle/grain size, strongly absorbing compounds, compounds with optically opaque bands in the infrared. | 7 | Physical Chemistry |
DNA methylation in cancer plays a variety of roles, helping to change the healthy cells by regulation of gene expression to a cancer cells or a diseased cells disease pattern. One of the most widely studied DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or causing genes to be silenced.
All mammalian cells descended from a fertilized egg (a zygote) share a common DNA sequence (except for new mutations in some lineages). However, during development and formation of different tissues epigenetic factors change. The changes include histone modifications, CpG island methylations and chromatin reorganizations which can cause the stable silencing or activation of particular genes. Once differentiated tissues are formed, CpG island methylation is generally stably inherited from one cell division to the next through the DNA methylation maintenance machinery.
In cancer, a number of mutational changes are found in protein coding genes. Colorectal cancers typically have 3 to 6 driver mutations and 33 to 66 hitchhiker or passenger mutations that silence protein expression in the genes affected. However, transcriptional silencing may be more important than mutation in causing gene silencing in progression to cancer. In colorectal cancers about 600 to 800 genes are transcriptionally silenced, compared to adjacent normal-appearing tissues, by CpG island methylation. Such CpG island methylation has also been described in glioblastoma and mesothelioma. Transcriptional repression in cancer can also occur by other epigenetic mechanisms, such as altered expression of microRNAs. | 1 | Biochemistry |
Although the nuclearity of binary metal carbonyl clusters is usually six or fewer, carbido clusters often have higher nuclearities. Metal carbonyls of the iron and cobalt triads are well known to form carbido derivatives. Examples include [RhC(CO)] and [RuC(CO)]. Carbonyl carbides exist not only with fully encapsulated carbon (e.g., [FeC(CO)]) but also with exposed carbon centres as in FeC(CO) and FeC(CO). | 7 | Physical Chemistry |
A number of organic compounds form charge-transfer complex, which are often described as electron-donor-acceptor complexes (EDA complexes). Typical acceptors are nitrobenzenes or tetracyanoethylene (TCNE). The strength of their interaction with electron donors correlates with the ionization potentials of the components. For TCNE, the stability constants (L/mol) for its complexes with benzene derivatives correlates with the number of methyl groups: benzene (0.128), 1,3,5-trimethylbenzene (1.11), 1,2,4,5-tetramethylbenzene (3.4), and hexamethylbenzene (16.8).
1,3,5-Trinitrobenzene and related polynitrated aromatic compounds, being electron-deficient, form charge-transfer complexes with many arenes. Such complexes form upon crystallization, but often dissociate in solution to the components. Characteristically, these CT salts crystallize in stacks of alternating donor and acceptor (nitro aromatic) molecules, i.e. A-B-A-B. | 7 | Physical Chemistry |
Reactions in chemical processes are either unimolecular or bimolecular. The rate of a unimolecular reaction is an average over a vast ensemble of the rate coefficients for the microscopic events of collisional energy transfer and of reaction of a completely isolated molecule. Gilberts work in the field of unimolecular processes started with the development of theorems for this relationship. These theorems are elegant developments in matrix algebra, proving relations that had been previously known only for particular cases. His theorems also became the basis for numerical methods that he developed to perform the requisite calculations. For this purpose, he created a computer code, UNIMOL', which is widely used by researchers.
He developed, with Prof J Troe, easily used approximate solutions for the pressure dependence of the rate coefficient. He provided the first solutions for cases where angular momentum conservation needs to be incorporated. His methods are used by experimentalists to fit data and extrapolate to different pressure regimes, supplanting previous tools which were of dubious validity and accuracy. His coworkers and he obtained data on the collisional energy transfer process and used them to prove the conjecture that each collision involves only a small exchange of energy. He then developed the first rigorous means to calculate these quantities from basic theory, and the first physical model for the process. His work is widely used, both for basic understanding of the transition states and by atmospheric and combustion modellers. Predicting climate change and effects on the ozone layer rely critically on this modelling. | 0 | Organic Chemistry |
Howard E. Zimmerman was a native of Connecticut. During World War II, he served in the U.S. Armored Corps in Europe where he was a tank gunner. His final rank was technical sergeant. He obtained a B. S. in Chemistry in 1950 and a Ph.D. in 1953 both from Yale University. He was a Postdoctoral Research Fellow with a National Research Council fellowship from 1953 to 1954 working with R. B. Woodward (Harvard). From 1954 to 1960 he was assistant professor at Northwestern University. Beginning in 1960 he was Associate Professor and then Professor at the University of Wisconsin, and from 1990 he was Hilldale and A. C. Cope Professor of Chemistry. His publications number over 285 (including 11 chapters).
Zimmerman gave ACS Short Courses on organic quantum chemistry and molecular orbital theory. He authored a 1975 textbook entitled Quantum Mechanics for Organic Chemists. Zimmerman was the organizer of the 1972 IUPAC Photochemistry Symposium (Baden-Baden) and of five Pacifichem Symposia – the last being Pacifichem 2010. | 5 | Photochemistry |
The DNA of interest needs to be fragmented to provide a relevant DNA segment of suitable size. Preparation of DNA fragments for cloning is achieved by means of PCR, but it may also be accomplished by restriction enzyme digestion and fractionation by gel electrophoresis. | 1 | Biochemistry |
Monomers capable of forming single, double, triple or quadruple hydrogen bonding has been utilized for making supramolecular polymers, and increased association of monomers obviously possible when monomers have maximum number of hydrogen bonding donor/acceptor motifs. For instance, ureidopyrimidinone-based monomer with self-complementary quadruple hydrogen bonding termini polymerized in solution, accordingly with the theory of conventional polymers and displayed a distinct viscoelastic nature at ambient temperatures. | 6 | Supramolecular Chemistry |
DLVO theory describes the interaction potential between charged surfaces. It is the sum of electrostatic double layer, which can be either attractive of repulsive, and attractive Van der Waals interactions of the charge surfaces. DLVO theory is applied widely in explaining the aggregation and deposition of colloidal and nano particles such as Fullerene C60 in aquatic system. Because bacteria and colloid particles both share the similarities in size and surface charge, the deposition of bacteria also can be describe by the DLVO theory. The prediction is based on sphere-plate interaction for one cell and the surface.<br />
The electrostatic double layer interactions could be describes by the expression for the constant surface potential
Where εis the vacuum permittivity, ε is the relative dielectric permittivity of water, a is the equivalent spherical radius of the bacteria, κ is the inverse of Debye length, h is the separation distance between the bacterium and the collector surface; ψ and ψ are the surface potentials of the bacterial cell and the collector surface. Zeta potential at the surface of the bacteria and the collector were used instead of the surface potential.
The retarded Van der Waals interaction potential was calculated using the expression from Gregory, 1981 .
With A is Hamaker constant for bacteria-water-surface collector (quartz) = 6.5 x 10 J and λ is the characteristic wavelength of the dielectric and could be assumed 100 nm, a is the equivalent radius of the bacteria, h is the separation distance from the surface collector to the bacteria.
Thus, the total interaction between bacteria and charged surface can be expressed as follow | 7 | Physical Chemistry |
Ethene and oxygen are passed co-currently in a reaction tower at about 130 °C and 400 kPa. The catalyst is an aqueous solution of PdCl and CuCl. The acetaldehyde is purified by extractive distillation followed by fractional distillation. Extractive distillation with water removes the lights ends having lower boiling points than acetaldehyde (chloromethane, chloroethane, and carbon dioxide) at the top, while water and higher-boiling byproducts, such as acetic acid, crotonaldehyde or chlorinated acetaldehydes, are withdrawn together with acetaldehyde at the bottom.
Due to the corrosive nature of catalyst, the reactor is lined with acid-proof ceramic material and the tubing is made of titanium. | 0 | Organic Chemistry |
Thiiranes occur very rarely in nature and are of no significance medicinally.
Very few commercial applications exist, although the polymerization of episulfide has been reported. | 0 | Organic Chemistry |
The crystal structures of the THF complexes of the Reformatsky reagents tert-butyl bromozincacetate and ethyl bromozincacetate have been determined. Both form cyclic eight-membered dimers in the solid state, but differ in stereochemistry: the eight-membered ring in the ethyl derivative adopts a tub-shaped conformation and has cis bromo groups and cis THF ligands, whereas in the tert-butyl derivative, the ring is in a chair form and the bromo groups and THF ligands are trans. Note that, in contrast to lithium and boron enolates, which have the metal(loid)s exclusively bond to oxygen, the zinc enolate moiety in the Reformatsky reagents have zinc atoms that are simultaneously O- and C-bound and can therefore be described as "organometallic". | 0 | Organic Chemistry |
One case study investigated the formation of gaseous intermediates in the decomposition of CCl in the presence of steam over LaO using Fourier-transform infrared spectroscopy. This experiment produced useful information about the reaction mechanism, active site orientation, and about which species compete for the active site. | 7 | Physical Chemistry |
In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. Its expression requires appropriate hormonal stimulation by FSH and estradiol. The LHCGR is present on granulosa cells, theca cells, luteal cells, and interstitial cells The LCGR is restimulated by increasing levels of chorionic gonadotropins in case a pregnancy is developing. In turn, luteal function is prolonged and the endocrine milieu is supportive of the nascent pregnancy. | 1 | Biochemistry |
Even though glycosylation is the most common form of protein modification, with highly complex carbohydrate structures, the bioinformatics on glycome is still very poor.
Unlike proteins and nucleic acids which are linear, carbohydrates are often branched and extremely complex. For instance, just four sugars can be strung together to form more than 5 million different types of carbohydrates or nine different sugars may be assembled into 15 million possible four-sugar-chains.
Also, the number of simple sugars that make up glycans is more than the number of nucleotides that make up DNA or RNA. Therefore, it is more computationally expensive to evaluate their structures.
One of the main constrains in the glycoinformatics is the difficulty of representing sugars in the sequence form especially due to their branching nature. Owing to the lack of a genetic blue print, carbohydrates do not have a "fixed" sequence. Instead, the sequence is largely determined by the presence of a variety of enzymes, their kinetic differences and variations in the biosynthetic micro-environment of the cells. This increases the complexity of analysis and experimental reproducibility of the carbohydrate structure of interest. It is for this reason that carbohydrates are often considered as the "information poor" molecules. | 0 | Organic Chemistry |
In more general use, a calibration curve is a curve or table for a measuring instrument which measures some parameter indirectly, giving values for the desired quantity as a function of values of sensor output. For example, a calibration curve can be made for a particular pressure transducer to determine applied pressure from transducer output (a voltage). Such a curve is typically used when an instrument uses a sensor whose calibration varies from one sample to another, or changes with time or use; if sensor output is consistent the instrument would be marked directly in terms of the measured unit. | 1 | Biochemistry |
A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation. | 1 | Biochemistry |
Small RNAs are noncoding RNA molecules between 20 and 200 nucleotide in length. The item "small RNA" is a rather arbitrary term, which is vaguely defined based on its length comparing with regular RNA such as messenger RNA (mRNA). Previously bacterial short regulatory RNAs have been referred to as small RNAs, but they are not related to eukaryotic small RNAs.
Small RNAs include several different classes of noncoding RNAs, depending on their sizes and functions: snRNA, snoRNA, scRNA, piRNA, miRNA, YRNA, tsRNA, rsRNA, and siRNA. Their functions go from RNAi (specific for endogenously expressed miRNA and exogenously derived siRNA), RNA processing and modification, gene silencing (i.g. X chromosome inactivation by Xist RNA), epigenetics modifications, protein stability and transport. | 1 | Biochemistry |
In complexation catalysis, the term passive binding refers to any stabilizing interaction that is equally strong at the transition state level and in the reactant-catalyst complex.
Having the same effect on the stability of the transition state and the reactant-catalyst complex, passive binding contributes to acceleration only if the equilibrium between the unassociated reactant and catalyst and their complex is not completely shifted to the right. It was defined by A.J. Kirby in 1996 as opposed to the dynamic binding, i.e. the whole of interactions that are stronger at the transition state level than in the reactant-catalyst complex. | 7 | Physical Chemistry |
In reaction kinetics, a rate effect is sometimes observed between different isotopomers of the same chemical. This kinetic isotope effect can be used to study reaction mechanisms by analyzing how the differently massed atom is involved in the process. | 4 | Stereochemistry |
Two primary classes of thermodynamic cycles are power cycles and heat pump cycles. Power cycles are cycles which convert some heat input into a mechanical work output, while heat pump cycles transfer heat from low to high temperatures by using mechanical work as the input. Cycles composed entirely of quasistatic processes can operate as power or heat pump cycles by controlling the process direction. On a pressure–volume (PV) diagram or temperature–entropy diagram, the clockwise and counterclockwise directions indicate power and heat pump cycles, respectively. | 7 | Physical Chemistry |
Native ironwork in the Northwest Coast has been found in places like the Ozette Indian Village Archeological Site, where iron chisels and knives were discovered. These artifacts seem to have been crafted around 1613, based on the dendrochronological analysis of associated pieces of wood in the site, and were made out of drift iron from Asian (specifically Japanese) shipwrecks, which were swept by the Kuroshio Current towards the coast of North America.
The tradition of working with Asian drift iron was well-developed in the Northwest before European contact, and was present among several native peoples from the region, including the Chinookan peoples and the Tlingit, who seem to have had their own specific word for the metallic material, which was transcribed by Frederica De Laguna as gayES. The wrecking of Japanese and Chinese vessels in the North Pacific basin was fairly common, and the iron tools and weaponry they carried provided the necessary materials for the development of the local ironwork traditions among the Northwestern Pacific Coast peoples,
although there were also other sources of iron, like that from meteorites, which was occasionally worked using stone anvils. | 8 | Metallurgy |
The structure function, like the fragmentation function, is a probability density function in physics. It is somewhat analogous to the structure factor in solid-state physics, and the form factor (quantum field theory).
The nucleon (proton and neutron) electromagnetic form factors describe the spatial distributions of electric charge and current inside the nucleon and thus are intimately related to its internal structure; these form factors are among the most basic observables of the nucleon. (Nucleons are the building blocks of almost all ordinary matter in the universe. The challenge of understanding the nucleon's structure and dynamics has occupied a central place in nuclear physics.)
The structure functions are important in the study of deep inelastic scattering.
The fundamental understanding of structure functions in terms of QCD is one of the outstanding problems in hadron physics. Why do quarks form colourless hadrons with only two stable configurations, proton and neutron? One important step towards answering this question is to characterize the internal structure of the nucleon. High energy electron scattering provides one of the most powerful tools to investigate this structure. | 7 | Physical Chemistry |
Current trends in climate change lead to higher ocean temperatures and acidity, thus modifying marine ecosystems. Also, acid rain and polluted runoff from agriculture and industry change the oceans chemical composition. Such changes can have dramatic effects on highly sensitive ecosystems such as coral reefs, thus limiting the oceans ability to absorb carbon from the atmosphere on a regional scale and reducing oceanic biodiversity globally.
The exchanges of carbon between the atmosphere and other components of the Earth system, collectively known as the carbon cycle, currently constitute important negative (dampening) feedbacks on the effect of anthropogenic carbon emissions on climate change. Carbon sinks in the land and the ocean each currently take up about one-quarter of anthropogenic carbon emissions each year.
These feedbacks are expected to weaken in the future, amplifying the effect of anthropogenic carbon emissions on climate change. The degree to which they will weaken, however, is highly uncertain, with Earth system models predicting a wide range of land and ocean carbon uptakes even under identical atmospheric concentration or emission scenarios. Arctic methane emissions indirectly caused by anthropogenic global warming also affect the carbon cycle and contribute to further warming. | 5 | Photochemistry |
Bowen was born in Oxford, son of the chemist Edmund Bowen and Edith Bowen (nee Moule). He attended the Dragon School, gaining a scholarship to Rugby School and then a demyship to Magdalen College, Oxford. He won the Gibbs Prize in 1949 and completed a DPhil in chemistry at Oxford University in 1953 before starting his professional career as a chemist. Bowen was also a proficient amateur actor in his early years, appearing with a young Ronnie Barker at Oxford. | 3 | Analytical Chemistry |
Of the seven metals known in antiquity, only gold regularly occurs in nature as a native metal. The others – copper, lead, silver, tin, iron, and mercury – occur primarily as minerals, although native copper is occasionally found in commercially significant quantities. These minerals are primarily carbonates, sulfides, or oxides of the metal, mixed with other components such as silica and alumina. Roasting the carbonate and sulfide minerals in the air converts them to oxides. The oxides, in turn, are smelted into the metal. Carbon monoxide was (and is) the reducing agent of choice for smelting. It is easily produced during the heating process, and as a gas comes into intimate contact with the ore.
In the Old World, humans learned to smelt metals in prehistoric times, more than 8000 years ago. The discovery and use of the "useful" metals – copper and bronze at first, then iron a few millennia later – had an enormous impact on human society. The impact was so pervasive that scholars traditionally divide ancient history into Stone Age, Bronze Age, and Iron Age.
In the Americas, pre-Inca civilizations of the central Andes in Peru had mastered the smelting of copper and silver at least six centuries before the first Europeans arrived in the 16th century, while never mastering the smelting of metals such as iron for use with weapon craft. | 8 | Metallurgy |
scVelo is a method that solves the full transcriptional dynamics of splicing kinetics using a likelihood-based dynamical model. This generalizes RNA velocity to systems with transient cell states, which are common in development and in response to perturbations. scVelo was applied to disentangling subpopulation kinetics in neurogenesis and pancreatic endocrinogenesis. scVelo demonstrate the capabilities of the dynamical model on various cell lineages in hippocampal dentate gyrus neurogenesis and pancreatic endocrinogenesis. | 1 | Biochemistry |
Control over surface wettability is a critical aspect of self-cleaning surfaces. Both superhydrophobic and superhydrophilic surfaces have been used as self-cleaning materials. | 7 | Physical Chemistry |
The Clyde cancer cluster (also known as the Sandusky County cancer cluster) is a childhood cancer cluster that has affected many families in Clyde, Ohio, and surrounding areas. PCBs were found in soil in a public park within the area of the cancer cluster.
In Akron, Ohio, soil was contaminated and noxious PCB-laden fumes had been put into the air by an electrical transformer deconstruction operation from the 1930s to the 1960s. | 2 | Environmental Chemistry |
The Haber–Weiss reaction generates •OH (hydroxyl radicals) from HO (hydrogen peroxide) and superoxide (•O) catalyzed by iron ions. It was first proposed by Fritz Haber and his student Joseph Joshua Weiss in 1932.
This reaction has long been studied and revived in different contexts, including organic chemistry, free radicals, radiochemistry, and water radiolysis. In the 1970, with the emerging interest for the effect of free radicals onto the ageing mechanisms of living cells due to oxygen (O), it was proposed that the Haber–Weiss reaction was a source of radicals responsible for cellular oxidative stress. However, this hypothesis was later disproved by several research works. The oxidative stress toxicity is not caused by the Haber–Weiss reaction as a whole, but by the Fenton reaction, which is one specific part of it.
The reaction is kinetically slow, but is catalyzed by dissolved iron ions. The first step of the catalytic cycle involves the reduction of the ferric (Fe) ion into the ferrous (Fe) ion:
:Fe + •O → Fe + O
The second step is the Fenton reaction:
:Fe + HO → Fe + OH + •OH
Net reaction:
:•O + HO → •OH + OH + O | 2 | Environmental Chemistry |
The Cori cycle (also known as the lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, is a metabolic pathway in which lactate, produced by anaerobic glycolysis in muscles, is transported to the liver and converted to glucose, which then returns to the muscles and is cyclically metabolized back to lactate. | 1 | Biochemistry |
In physics, a phason is a form of collective excitation found in aperiodic crystal structures. Phasons are a type of quasiparticle: an emergent phenomenon of many-particle systems. Similar to phonons, phasons are quasiparticles associated with atomic motion. However, whereas phonons are related to the translation of atoms, phasons are associated with atomic rearrangement. As a result of this rearrangement, or modulation, the waves that describe the position of atoms in the crystal change phase -- hence the term "phason".
Phasons can travel faster than the speed of sound within quasicrystalline materials, giving these materials a higher thermal conductivity than materials in which the transfer of heat is carried out only by phonons. Different phasonic modes can change the material properties of a quasicrystal.
Within superspace representation, aperiodic crystals can be obtained by taking a section of a periodic crystal of higher dimension (up to 6D) and cutting at an irrational angle. While phonons change the position of atoms relative to the crystal structure in space, phasons change the position of atoms relative to the quasicrystal structure and the cut-through superspace that defines it. Therefore, phonon modes are excitations of the "in-plane" real (also called parallel or external) space, whereas phasons are excitations of the perpendicular (also called internal) space.
Models of describing phasons include hydrodynamic theory (which describes phasons as a continuous pattern of motion), and phasonic flips, where atoms collectively jump to new sites. Hydrodynamic analysis of quasicrystals predicts that, while the strain relaxation of phonons is relatively rapid, relaxation of phason strain is diffusive and is much slower. Therefore, metastable quasicrystals grown by rapid quenching from the melt exhibit built-in phason strain associated with shifts and anisotropic broadenings of X-ray and electron diffraction peaks. | 3 | Analytical Chemistry |
Butyrate that is produced in the colon through microbial fermentation of dietary fiber is primarily absorbed and metabolized by colonocytes and the liver for the generation of ATP during energy metabolism; however, some butyrate is absorbed in the distal colon, which is not connected to the portal vein, thereby allowing for the systemic distribution of butyrate to multiple organ systems through the circulatory system. Butyrate that has reached systemic circulation can readily cross the blood–brain barrier via monocarboxylate transporters (i.e., certain members of the SLC16A group of transporters). Other transporters that mediate the passage of butyrate across lipid membranes include SLC5A8 (SMCT1), SLC27A1 (FATP1), and SLC27A4 (FATP4). | 1 | Biochemistry |
In most dewetting studies a thin polymer film is spin-cast onto a substrate. Even in the case of the film does not dewet immediately if it is in a metastable state, e.g. if the temperature is below the glass transition temperature of the polymer. Annealing such a metastable film above its glass transition temperature increases the mobility of the polymer-chain molecules and dewetting takes place.
The process of dewetting occurs by the nucleation and growth of randomly formed holes, which coalesce to form a network of filaments, before breaking into droplets. When starting from a continuous film, an irregular pattern of droplets is formed. The droplet size and droplet spacing may vary over several orders of magnitude, since the dewetting starts from randomly formed holes in the film. There is no spatial correlation between the dry patches that develop. These dry patches grow and the material is accumulated in the rim surrounding the growing hole. In the case where the initially homogeneous film is thin (in the range of 100 nm), a polygon network of connected strings of material is formed, like a Voronoi pattern of polygons. These strings then can break up into droplets, a process which is known as the Plateau-Rayleigh instability. At other film thicknesses, other complicated patterns of droplets on the substrate can be observed, which stem from a fingering instability of the growing rim around the dry patch. | 7 | Physical Chemistry |
Phenol in the Berthelot reagent can be replaced by a variety of phenolic reagents, the most common being sodium salicylate, which is significantly less toxic. This has been used for blood urea nitrogen (BUN) determinations and commonly is used to determine water and soil total and ammonia-N. Replacement of phenol by 2-phenylphenol reduces interferences by a variety of soil and water constituents and improves color stability at slightly lower pH. | 3 | Analytical Chemistry |
Box models are widely used to model biogeochemical systems. Box models are simplified versions of complex systems, reducing them to boxes (or storage reservoirs) for chemical materials, linked by material fluxes (flows). Simple box models have a small number of boxes with properties, such as volume, that do not change with time. The boxes are assumed to behave as if they were mixed homogeneously. These models are often used to derive analytical formulas describing the dynamics and steady-state abundance of the chemical species involved.
The diagram at the right shows a basic one-box model. The reservoir contains the amount of material M under consideration, as defined by chemical, physical or biological properties. The source Q is the flux of material into the reservoir, and the sink S is the flux of material out of the reservoir. The budget is the check and balance of the sources and sinks affecting material turnover in a reservoir. The reservoir is in a steady state if Q = S, that is, if the sources balance the sinks and there is no change over time.
The turnover time (also called the renewal time or exit age) is the average time material spends resident in the reservoir. If the reservoir is in a steady state, this is the same as the time it takes to fill or drain the reservoir. Thus, if τ is the turnover time, then τ = M/S. The equation describing the rate of change of content in a reservoir is
When two or more reservoirs are connected, the material can be regarded as cycling between the reservoirs, and there can be predictable patterns to the cyclic flow. More complex multibox models are usually solved using numerical techniques.
The diagram above shows a simplified budget of ocean carbon flows. It is composed of three simple interconnected box models, one for the euphotic zone, one for the ocean interior or dark ocean, and one for ocean sediments. In the euphotic zone, net phytoplankton production is about 50 Pg C each year. About 10 Pg is exported to the ocean interior while the other 40 Pg is respired. Organic carbon degradation occurs as particles (marine snow) settle through the ocean interior. Only 2 Pg eventually arrives at the seafloor, while the other 8 Pg is respired in the dark ocean. In sediments, the time scale available for degradation increases by orders of magnitude with the result that 90% of the organic carbon delivered is degraded and only 0.2 Pg C yr is eventually buried and transferred from the biosphere to the geosphere. | 9 | Geochemistry |
Calcium 5'-ribonucleotides is a mixture used as a flavor enhancer food additive. It listed as E number reference E634. This food additive is banned in Australia and New Zealand. | 1 | Biochemistry |
Note the contrasting definitions between partial molar quantity and apparent molar quantity: in the case of partial molar volumes , defined by partial derivatives
one can write , and so always holds. In contrast, in the definition of apparent molar volume, the molar volume of the pure solvent, , is used instead, which can be written as
for comparison. In other words, we assume that the volume of the solvent does not change, and we use the partial molar volume where the number of moles of the solute is exactly zero ("the molar volume"). Thus, in the defining expression for apparent molar volume ,
the term is attributed to the pure solvent, while the "leftover" excess volume, , is considered to originate from the solute. At high dilution with , we have , and so the apparent molar volume and partial molar volume of the solute also converge: .
Quantitatively, the relation between partial molar properties and the apparent ones can be derived from the definition of the apparent quantities and of the molality. For volume, | 7 | Physical Chemistry |
The main method of producing yogurt is through the lactic acid fermentation of milk with harmless bacteria. The primary bacteria used are typically Lactobacillus bulgaricus and Streptococcus thermophilus, and United States as well as European law requires all yogurts to contain these two cultures (though others may be added as probiotic cultures). These bacteria produce lactic acid in the milk culture, decreasing its pH and causing it to congeal. The bacteria also produce compounds that give yogurt its distinctive flavor. An additional effect of the lowered pH is the incompatibility of the acidic environment with many other types of harmful bacteria.
For a probiotic yogurt, additional types of bacteria such as Lactobacillus acidophilus are also added to the culture. | 1 | Biochemistry |
Dr. Diana Fleischman, of the University of Portsmouth, and colleagues looked for a relationship between progesterone and sexual attitudes in 92 women. Their research, published in the Archives of Sexual Behavior found that women who had higher levels of progesterone scored higher on a questionnaire measuring homoerotic motivation. They also found that men who had high levels of progesterone were more likely to have higher homoerotic motivation scores after affiliative priming compared to men with low levels of progesterone. | 0 | Organic Chemistry |
At 400 ppb, fluorine is estimated to be the 24th most common element in the universe. It is comparably rare for a light element (elements tend to be more common the lighter they are). All of the elements from atomic number 6 (carbon) to atomic number 12 (magnesium) are hundreds or thousands of times more common than fluorine except for 11 (sodium). One science writer described fluorine as a "shack amongst mansions" in terms of abundance. Fluorine is so rare because it is not a product of the usual nuclear fusion processes in stars. And any created fluorine within stars is rapidly eliminated through strong nuclear fusion reactions—either with hydrogen to form oxygen and helium, or with helium to make neon and hydrogen. The presence of fluorine at all—outside of temporary existence in stars—is somewhat of a mystery because of the need to escape these fluorine-destroying reactions.
Three theoretical solutions to the mystery exist: In type II supernovae, atoms of neon could be hit by neutrinos during the explosion and converted to fluorine. In Wolf-Rayet stars (blue stars over 40 times heavier than the Sun), a strong solar wind could blow the fluorine out of the star before hydrogen or helium could destroy it. Finally, in asymptotic giant branch (a type of red giant) stars, fusion reactions occur in pulses and convection could lift fluorine out of the inner star. Only the red giant hypothesis has supporting evidence from observations, fluorine cations have been found in planetary nebulae.
In space, fluorine commonly combines with hydrogen to form hydrogen fluoride. (This compound has been suggested as a tracer to enable tracking reservoirs of hydrogen in the universe.) In addition to HF, monatomic fluorine has been observed in the interstellar medium. Fluorine cations have been seen in planetary nebulae and in stars, including the Sun. | 9 | Geochemistry |
VIPA devices have been commercialized by LightMachinery as spectral disperser devices or components with various customized design parameters. | 7 | Physical Chemistry |
Mitogens can be either endogenous or exogenous factors. Endogenous mitogens function to control cell division is a normal and necessary part of the life cycle of multicellular organisms. For example, in zebrafish, an endogenous mitogen Nrg1 is produced in response to indications of heart damage. When it is expressed, it causes the outer layers of the heart to respond by increasing division rates and producing new layers of heart muscle cells to replace the damaged ones. This pathway can potentially be deleterious, however: expressing Nrg1 in the absence of heart damage causes uncontrolled growth of heart cells, creating an enlarged heart. Some growth factors, such as vascular endothelial growth factor, are also capable of directly acting as mitogens, causing growth by directly inducing cell replication. This is not true for all growth factors, as some growth factors instead appear to cause mitogenic effects like growth indirectly by triggering other mitogens to be released, as evidenced by their lack of mitogenic activity in vitro, which VEGF has. Other well-known mitogenic growth factors include platelet derived growth factor (PDGF) and epidermal growth factor (EGF). | 1 | Biochemistry |
In Saxon settlements such as one identified in Northumberland as Bedes Ad Gefrin (now called Yeavering) the buildings were shown by an excavators reconstruction to have opposed entries. In barns a draught created by the use of these opposed doorways was used in winnowing.
The technique developed by the Chinese was not adopted in Europe until the 18th century when winnowing machines used a sail fan. The rotary winnowing fan was exported to Europe, brought there by Dutch sailors between 1700 and 1720. Apparently, they had obtained them from the Dutch settlement of Batavia in Java, Dutch East Indies. The Swedes imported some from south China at about the same time and Jesuits had taken several to France from China by 1720. Until the beginning of the 18th century, no rotary winnowing fans existed in the West. | 3 | Analytical Chemistry |
Eshelby was elected a Fellow of the Royal Society in March 1974. He was awarded the Timoshenko Medal in 1977.
In 2012, the Eshelby Mechanics Award for Young Faculty and the Eshelby Memorial Bursary was founded in his memory. was launched to commemorate the memory of Eshelby. The award is given annually to rapidly emerging junior faculty who exemplify the creative use and development of mechanics, and awardees are formally recognised at the annual Applied Mechanics Division Banquet at the American Society of Mechanical Engineers' International Mechanical Engineering Congress and Exposition (ASME-IMECE) meeting. | 8 | Metallurgy |
Water vapor will only condense onto another surface when that surface is cooler than the dew point temperature, or when the water vapor equilibrium in air has been exceeded. When water vapor condenses onto a surface, a net warming occurs on that surface. The water molecule brings heat energy with it. In turn, the temperature of the atmosphere drops slightly. In the atmosphere, condensation produces clouds, fog and precipitation (usually only when facilitated by cloud condensation nuclei). The dew point of an air parcel is the temperature to which it must cool before water vapor in the air begins to condense. Condensation in the atmosphere forms cloud droplets.
Also, a net condensation of water vapor occurs on surfaces when the temperature of the surface is at or below the dew point temperature of the atmosphere. Deposition is a phase transition separate from condensation which leads to the direct formation of ice from water vapor. Frost and snow are examples of deposition.
There are several mechanisms of cooling by which condensation occurs:
1) Direct loss of heat by conduction or radiation.
2) Cooling from the drop in air pressure which occurs with uplift of air, also known as adiabatic cooling.
Air can be lifted by mountains, which deflect the air upward, by convection, and by cold and warm fronts.
3) Advective cooling - cooling due to horizontal movement of air. | 2 | Environmental Chemistry |
In November 1990, Çeçen joined the faculty at the Boğaziçi University Institute of Environmental Sciences as an instructor. She was promoted to assistant professor in March 1993, associate professor in October 1993, and full professor in June 1999.
Çeçen researches water and wastewater treatment, environmental biotechnology, adsorption processes, and the impacts of hazardous substances on biological treatment. | 2 | Environmental Chemistry |
After a chloroplast polypeptide is synthesized on a ribosome in the cytosol, an enzyme specific to chloroplast proteins phosphorylates, or adds a phosphate group to many (but not all) of them in their transit sequences.
Phosphorylation helps many proteins bind the polypeptide, keeping it from folding prematurely. This is important because it prevents chloroplast proteins from assuming their active form and carrying out their chloroplast functions in the wrong place—the cytosol. At the same time, they have to keep just enough shape so that they can be recognized by the chloroplast. These proteins also help the polypeptide get imported into the chloroplast.
From here, chloroplast proteins bound for the stroma must pass through two protein complexes—the TOC complex, or translocon on the outer chloroplast membrane, and the TIC translocon, or translocon on the inner chloroplast membrane translocon. Chloroplast polypeptide chains probably often travel through the two complexes at the same time, but the TIC complex can also retrieve preproteins lost in the intermembrane space. | 5 | Photochemistry |
The European Bioanalysis Forum (EBF) is an organisation comprising bioanalytical scientists working within the pharmaceutical industry R&D. Scope of the EBF is on bioanalysis of small and large molecules with bioanalysis being defined as:
* Quantification of drugs and metabolites in body fluids and tissues
* Quantification of PD and safety biomarkers amenable to conventional bioanalytical techniques
* Bioanalytical characterization of NBEs
Members discuss on regulatory issues and aspects (new guidelines, interpretation of existing guidelines) and present their joint opinion towards regulatory bodies and their peers. Further, they share common practices on procedures, science, Laboratory Information Management Systems (LIMS), validation, quality (GLP) and discuss new developments in industry. | 3 | Analytical Chemistry |
Corinthian bronze, also named Corinthian brass or aes Corinthiacum, was a highly valuable metal alloy in classical antiquity. It is thought to be an alloy of copper with gold or silver (or both), although it has also been contended that it was simply a very high grade of bronze, or a kind of bronze that was manufactured in Corinth. It is referred to in various ancient texts, but no certain examples of Corinthian bronze exist today. However, it has been increasingly suggested that a number of artefacts previously described as niello in fact use a technique of patinated metal that may be the same as Corinthian bronze and is similar to the Japanese Shakudō.
Its composition was long a mystery, but contemporary thinking is that Corinthian bronze was "a patinated alloy of copper with some gold and silver", perhaps the same as the hesmen kem or "black copper" of Ancient Egyptian art. This is shown by ancient texts to be a prestigious material, and apparently survives in a number of statuettes of "distinctive black-patinated, inlaid metal", of which scientific analysis shows "that some have a highly unusual composition containing small amounts of gold, silver and arsenic in the alloy", and are broadly similar to Shakudō. | 8 | Metallurgy |
Schrock carbenes do not have π-accepting ligands on the metal centre, and are typically found with:
* high oxidation state metal center
* early transition metals Ti(IV), Ta(V)
* σ-donor and sometimes π-donor metal ligands
* hydrogen and alkyl substituents on carbenoid carbon.
Examples include and .
Bonding in such complexes can be viewed as the coupling of a triplet state metal and triplet carbene, forming a true double bond. Both the metal and carbon atom donate 2 electrons, one to each bond. Since there is no donation to the carbene atom from adjacent groups, the extent of pi backbonding is much greater, giving a strong double bond. These bonds are weakly polarized towards carbon and therefore the carbene atom is a nucleophile. Furthermore, the major resonance structures of Schrock carbene put the negative charge on the carbon atom, making it nucleophilic. Complexes with the methylidene ligand () are the simplest Schrock-type carbenes. | 0 | Organic Chemistry |
The absorption refrigerator is of unique importance in setting an autonomous quantum device.
Such a device requires no external power and operates without external intervention in scheduling the operations
. The basic construct includes three baths; a power bath, a hot bath and a cold bath.
The tricycle model is the template for the absorption refrigerator.
The tricycle engine has a generic structure.
The basic model consists of three thermal baths: A hot bath with temperature ,
a cold bath with temperature
and a work bath with temperature .
Each bath is connected to the engine via a frequency filter which can be modeled by three oscillators:
where , and
are the filter frequencies on resonance .
The device operates as a refrigerator by removing an excitation from the cold bath as well as from the work bath
and generating an excitation in the hot bath. The term in the Hamiltonian is non linear
and crucial for an engine or a refrigerator.
where is the coupling strength.
The first-law of thermodynamics represents the energy balance of heat currents originating from the three baths and collimating on the system:
At steady state no heat is accumulated in the tricycle, thus .
In addition, in steady state the entropy is only generated in the baths, leading to the second law of thermodynamics:
This version of the second-law is a generalisation of the statement of Clausius theorem;
heat does not flow spontaneously from cold to hot bodies.
When the temperature , no entropy is generated in the power bath.
An energy current with no accompanying entropy production is equivalent to generating pure power:
, where is the power output. | 7 | Physical Chemistry |
Woodward also received over twenty honorary degrees, including honorary doctorates from the following universities:
* Wesleyan University in 1945;
* Harvard University in 1957;
* University of Cambridge in 1964;
* Brandeis University in 1965;
* Technion Israel Institute of Technology in Haifa in 1966;
* University of Western Ontario in Canada in 1968;
* University of Louvain in Belgium, 1970. | 4 | Stereochemistry |
In many nonlinear field theories like general relativity or Yang–Mills theories, the basic field equations are highly nonlinear and exact solutions are only known for ‘sufficiently symmetric’ distributions of matter (e.g. rotationally or axially symmetric configurations). Time-translation symmetry is guaranteed only in spacetimes where the metric is static: that is, where there is a coordinate system in which the metric coefficients contain no time variable. Many general relativity systems are not static in any frame of reference so no conserved energy can be defined. | 7 | Physical Chemistry |
Polymer characterization spans many techniques for determining the chemical composition, molecular weight distribution, and physical properties. Select common techniques include the following:
*Size-exclusion chromatography (also called gel permeation chromatography), sometimes coupled with static light scattering, can used to determine the number-average molecular weight, weight-average molecular weight, and dispersity.
*Scattering techniques, such as static light scattering and small-angle neutron scattering, are used to determine the dimensions (radius of gyration) of macromolecules in solution or in the melt. These techniques are also used to characterize the three-dimensional structure of microphase-separated block polymers, polymeric micelles, and other materials.
*Wide-angle X-ray scattering (also called wide-angle X-ray diffraction) is used to determine the crystalline structure of polymers (or lack thereof).
*Spectroscopy techniques, including Fourier-transform infrared spectroscopy, Raman spectroscopy, and nuclear magnetic resonance spectroscopy, can be used to determine the chemical composition.
*Differential scanning calorimetry is used to characterize the thermal properties of polymers, such as the glass-transition temperature, crystallization temperature, and melting temperature. The glass-transition temperature can also be determined by dynamic mechanical analysis.
*Thermogravimetry is a useful technique to evaluate the thermal stability of the polymer.
*Rheology is used to characterize the flow and deformation behavior. It can be used to determine the viscosity, modulus, and other rheological properties. Rheology is also often used to determine the molecular architecture (molecular weight, molecular weight distribution, branching) and to understand how the polymer can be processed. | 7 | Physical Chemistry |
During World War I, various forms of tear gas were used in combat and tear gas was the most common form of chemical weapon used. None of the belligerents believed that the use of irritant gases violated the Hague Convention of 1899 which prohibited the use of "poison or poisoned weapons" in warfare. Use of chemical weapons escalated during the war to lethal gases, after 1914 (during which only tear gas was used).
The US Chemical Warfare Service developed tear gas grenades for use in riot control in 1919.
Use of tear gas in interstate warfare, as with all other chemical weapons, was prohibited by the Geneva Protocol of 1925: it prohibited the use of "asphyxiating gas, or any other kind of gas, liquids, substances or similar materials", a treaty that most states have signed. Police and civilian self-defense use is not banned in the same manner.
Tear gas was used in combat by Italy in the Second Italo-Ethiopian War, by Japan in the Second Sino-Japanese War, by Spain in the Rif War and by the United States in the Vietnam War, and the Israel–Palestine conflict.
Tear gas exposure is an element of military training programs, typically as a means of improving trainees' tolerance to tear gas and encouraging confidence in the ability of their issued protective equipment to prevent chemical weapons exposure. | 1 | Biochemistry |
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