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Amorphous metals exhibit unique softening behavior above their glass transition and this softening has been increasingly explored for thermoplastic forming of metallic glasses. Such low softening temperature allows for developing simple methods for making composites of nanoparticles (e.g. carbon nanotubes) and bulk metallic glasses. It has been shown that metallic glasses can be patterned on extremely small length scales ranging from 10 nm to several millimeters. This may solve the problems of nanoimprint lithography where expensive nano-molds made of silicon break easily. Nano-molds made from metallic glasses are easy to fabricate and more durable than silicon molds. The superior electronic, thermal and mechanical properties of bulk metallic glasses compared to polymers make them a good option for developing nanocomposites for electronic application such as field electron emission devices.
TiCuPdZr is believed to be noncarcinogenic, is about three times stronger than titanium, and its elastic modulus nearly matches bones. It has a high wear resistance and does not produce abrasion powder. The alloy does not undergo shrinkage on solidification. A surface structure can be generated that is biologically attachable by surface modification using laser pulses, allowing better joining with bone.
MgZnCa, rapidly cooled to achieve amorphous structure, is being investigated at Lehigh University as a biomaterial for implantation into bones as screws, pins, or plates, to fix fractures. Unlike traditional steel or titanium, this material dissolves in organisms at a rate of roughly 1 millimeter per month and is replaced with bone tissue. This speed can be adjusted by varying the content of zinc.
Bulk metallic glasses also seem to exhibit superior properties like SAM2X5-630 which has the highest recorded elastic limit for any steel alloy, according to the researcher, essentially it has the highest threshold limit at which a material can withstand an impact without deforming permanently(plasticity). The alloy can withstand pressure and stress of up to without undergoing any permanent deformation, this is the highest impact resistance of any bulk metallic glass ever recorded (as of 2016) .This makes it as an attractive option for Armour material and other applications which requires high stress tolerance. | 8 | Metallurgy |
Desorption as well as reactions on surfaces are straightforward to describe with transition state theory. Analysis of adsorption to a surface from a liquid phase can present a challenge due to lack of ability to assess the concentration of the solute near the surface. When full details are not available, it has been proposed that reacting species' concentrations should be normalized to the concentration of active surface sites, an approximation called the surface reactant equi-density approximation (SREA). | 7 | Physical Chemistry |
Stepwise elongation, in which the amino acids are connected step-by-step in turn, is ideal for small peptides containing between 2 and 100 amino acid residues. Another method is fragment condensation, in which peptide fragments are coupled. Although the former can elongate the peptide chain without racemization, the yield drops if only it is used in the creation of long or highly polar peptides. Fragment condensation is better than stepwise elongation for synthesizing sophisticated long peptides, but its use must be restricted in order to protect against racemization. Fragment condensation is also undesirable since the coupled fragment must be in gross excess, which may be a limitation depending on the length of the fragment.
A new development for producing longer peptide chains is chemical ligation: unprotected peptide chains react chemoselectively in aqueous solution. A first kinetically controlled product rearranges to form the amide bond. The most common form of native chemical ligation uses a peptide thioester that reacts with a terminal cysteine residue.
Other methods applicable for covalently linking polypeptides in aqueous solution include the use of split inteins, spontaneous isopeptide bond formation and sortase ligation.
In order to optimize synthesis of long peptides, a method was developed in Medicon Valley for converting peptide sequences. The simple pre-sequence (e.g. Lysine (Lysn); Glutamic Acid (Glun); (LysGlu)n) that is incorporated at the C-terminus of the peptide to induce an alpha-helix-like structure. This can potentially increase biological half-life, improve peptide stability and inhibit enzymatic degradation without altering pharmacological activity or profile of action. | 1 | Biochemistry |
About 70% of the ingested imidapril is absorbed quickly from the gut; this percentage is reduced significantly when taken with a fatty meal. It reaches highest blood plasma concentrations after two hours and has a biological half-life of two hours. The substance is a prodrug and is activated to imidaprilat, which reaches highest plasma concentrations after 7 hours, has an initial half-life of 7 to 9 hours and a terminal half-life of more than 24 hours. The absolute bioavailability of imidaprilat is 42%.
About 40% of the drug is excreted via the urine and 50% via the bile and faeces. | 4 | Stereochemistry |
As mentioned above the histone tails have been shown to directly interact with the DNA of the nucleosome. Each histone in the octamer has an N-terminal tail that protrudes from the histone core. The tails play roles both in inter and intra nucleosomal interactions that ultimately influence gene access. Histones are positively charged molecules which allow a tighter bonding to the negatively charged DNA molecule. Reducing the positive charge of histone proteins reduces the strength of binding between the histone and DNA, making it more open to gene transcription (expression). Moreover, these flexible units direct DNA wrapping in a left-handed manner around the histone octamer during nucleosome formation. Once the DNA is bound the tails continue to interact with the DNA. The parts of the tail closest to the DNA hydrogen bond and strengthen the DNA's association with the octamer; the parts of the tail furthest away from the DNA, however, work in a very different manner. Cellular enzymes modify the amino acids in the distal sections of the tail to influence the accessibility of the DNA. The tails have also been implicated in the stabilization of 30-nm fibers. Research has shown removing certain tails prevents the nucleosomes from forming properly and a general failure to produce chromatin fiber. In all, these associations protect the nucleosomal DNA from the external environment but also lower their accessibility to cellular replication and transcriptional machinery. | 1 | Biochemistry |
Because dextromethorphan can trigger a histamine release (allergic reaction), atopic children, who are especially susceptible to allergic reactions, should be administered dextromethorphan only if absolutely necessary, and only under the strict supervision of a healthcare professional. | 4 | Stereochemistry |
DVS measurement has applications over a wide range of industries. Both equilibrium vapor sorption isotherms and vapor sorption kinetic results can yield vital information for materials ranging from pharmaceuticals to fuel cells. Although water sorption experiments are most common, the use of organic vapor in DVS experiments can reveal additional sample properties. The below sections highlight how DVS experiments are utilized in several industries. | 7 | Physical Chemistry |
While the halogens are not nucleophilic in their diatomic form (e.g. I is not a nucleophile), their anions are good nucleophiles. In polar, protic solvents, F is the weakest nucleophile, and I the strongest; this order is reversed in polar, aprotic solvents. | 7 | Physical Chemistry |
The versatility of the Sonogashira reaction makes it a widely used reaction in the synthesis of a variety of compounds. One such pharmaceutical application is in the synthesis of SIB-1508Y, which is more commonly known as Altinicline. Altinicline is a nicotinic acetylcholine receptor agonist that has shown potential in the treatment of Parkinsons disease, Alzheimers disease, Tourette's syndrome, schizophrenia, and attention deficit hyperactivity disorder (ADHD). As of 2008, Altinicline has undergone Phase II clinical trials.
The Sonogashira cross coupling reaction can be used in the synthesis of imidazopyridine derivatives. | 0 | Organic Chemistry |
Moreover, Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is best recognized for its roles in the brain, particularly in the neocortex and hippocampal regions because it serves as a ubiquitous mediator of cellular Ca2+ signals. CaMKII is abundant in the nervous system, mainly concentrated in the synapses in the nerve cells. Indeed, CaMKII has been definitively identified as a key regulator of cognitive processes, such as learning, and neural plasticity. The first concrete experimental evidence for the long-assumed function of CaMKII in memory storage was demonstrated
While Ca2+/CaM binding stimulates CaMKII activity, Ca2+-independent autonomous CaMKII activity can also be produced by a number of other processes. CaMKII becomes active by autophosphorylating itself upon Ca2+/calmodulin binding. CaMKII is still active and phosphorylates itself even after Ca2+ is cleaved; as a result, the brain stores long-term memories using this mechanism. Nevertheless, when the CaMKII enzyme is dephosphorylated by a phosphatase enzyme, it becomes inactive, and memories are lost. Hence, CaMKII plays a vital role in both the induction and maintenance of LTP. | 1 | Biochemistry |
The common technique of cleaning silverware by immersion of the silver or sterling silver (or even just silver plated objects) and a piece of aluminium (foil is preferred because of its much greater surface area than that of ingots, although if the foil has a "non-stick" face, this must be removed with steel wool first) in a hot electrolytic bath (usually composed of water and sodium bicarbonate, i.e., household baking soda) is an example of galvanic corrosion. Silver darkens and corrodes in the presence of airborne sulfur molecules, and the copper in sterling silver corrodes under a variety of conditions. These layers of corrosion can be largely removed through the electrochemical reduction of silver sulfide molecules: the presence of aluminium (which is less noble than either silver or copper) in the bath of sodium bicarbonate strips the sulfur atoms off the silver sulfide and transfers them onto and thereby corrodes the piece of aluminium foil (a much more reactive metal), leaving elemental silver behind. No silver is lost in the process. | 8 | Metallurgy |
Product imaging of positive ions formed by REMPI detection is only one of the areas where charged particle imaging has become useful. Another area was in the detection of electrons. The first ideas along these lines seem to have an early history. Demkov et al. were perhaps the first to propose a "photoionization microscope". They realized that trajectories of an electron emitted from an atom in different directions may intersect again at a large distance from the atom and create an interference pattern. They proposed building an apparatus to observe the predicted rings. Blondel et al. eventually realized such a "microscope" and used it to study the photodetachment of Br. It was Helm and co-workers, however, who were the first to create an electron imaging apparatus. The instrument is an improvement on previous photoelectron spectrometers in that it provides information on all energies and all angles of the photoelectrons for each shot of the laser. Helm and his co-workers have now used this technique to investigate the ionization of Xe, Ne, H, and Ar. In more recent examples, Suzuki, Hayden, and Stolow have pioneered the use of femtosecond excitation and ionization to follow excited state dynamics in larger molecules. | 7 | Physical Chemistry |
Transgender people who were medically assigned female at birth sometimes elect to take hormone replacement therapy. This process causes virilization by inducing many of the effects of a typically male puberty. Many of these effects are permanent, but some effects can be reversed if the transgender individual stops or pauses their medical treatment. | 1 | Biochemistry |
Reaction (a) is the sum of reactions (b) and (c), for which the total ΔH = −393.5 kJ/mol, which is equal to ΔH in (a).
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Sapropel (a contraction of Ancient Greek words sapros and pelos, meaning putrefaction and mud (or clay), respectively) is a term used in marine geology to describe dark-coloured sediments that are rich in organic matter. Organic carbon concentrations in sapropels commonly exceed 2 wt.% in weight.
The term sapropel events may also refer to cyclic oceanic anoxic event (OAE), in particular those affecting the Mediterranean Sea with a periodicity of about 21,000 years. | 9 | Geochemistry |
He was awarded a PhD is in physical chemistry from Battersea College of Technology. During his study he married a German in London in October 1963; their common language is English. Mrs al-Saadi raised their children in Hamburg.
He retired a lieutenant general in 1994 and was made a presidential scientific advisor. | 7 | Physical Chemistry |
Peptides are ancient signaling systems that are found in almost all animals on Earth. Genome sequencing reveals evidence of neuropeptide genes in Cnidaria, Ctenophora, and Placozoa, some of oldest living animals with nervous systems or neural-like tissues. Recent studies also show genomic evidence of neuropeptide processing machinery in metazoans and choanoflagellates, suggesting that neuropeptide signaling may predate the development of nervous tissues. Additionally, Ctenophore and Placozoa neural signaling is entirely peptidergic and lacks the major amine neurotransmitters such as acetylcholine, dopamine, and serotonin. This also suggests that neuropeptide signaling developed before amine neurotransmitters. | 1 | Biochemistry |
Sulfuric acid reacts with most bases to give the corresponding sulfate or bisulfate.
Sulfuric acid reacts with sodium chloride, and gives hydrogen chloride gas and sodium bisulfate:
Aluminium sulfate, also known as paper maker's alum, aluminium sulfate is made by treating bauxite with sulfuric acid:
Sulfuric acid can also be used to displace weaker acids from their salts. Reaction with sodium acetate, for example, displaces acetic acid, , and forms sodium bisulfate:
Similarly, treating potassium nitrate with sulfuric acid produces nitric acid.
When combined with nitric acid, sulfuric acid acts both as an acid and a dehydrating agent, forming the nitronium ion , which is important in nitration reactions involving electrophilic aromatic substitution. This type of reaction, where protonation occurs on an oxygen atom, is important in many organic chemistry reactions, such as Fischer esterification and dehydration of alcohols.
When allowed to react with superacids, sulfuric acid can act as a base and can be protonated, forming the ion. Salts of have been prepared (e.g. trihydroxyoxosulfonium hexafluoroantimonate(V) ) using the following reaction in liquid HF:
The above reaction is thermodynamically favored due to the high bond enthalpy of the Si–F bond in the side product. Protonation using simply fluoroantimonic acid, however, has met with failure, as pure sulfuric acid undergoes self-ionization to give ions:
which prevents the conversion of to by the HF/ system. | 7 | Physical Chemistry |
Micrometeorites have been collected from deep-sea sediments, sedimentary rocks and polar sediments. They were previously collected primarily from polar snow and ice because of their low concentrations on the Earth's surface, but in 2016 a method to extract micrometeorites in urban environments was discovered. | 9 | Geochemistry |
Third order spectroscopy, sometimes revered to as Aspnes's third-derivative, is a technique used to enhance the resolution of a spectroscopy measurement. This technique was first used by D.E. Aspnes to study electroreflectance in 1971. Using 3rd order derivatives can sharpen the peak of a function (see figure). Especially in spectroscopy, where the wave is never measured on one specific wavelength, but always on a band, it is use full to sharpen the peak, and thus narrow the band.
Another advantage of derivatives is that baseline shifts are eliminated since derivatives get rid of shifts. These shifts in spectra can for example be caused by sample handling, lamp or detector instabilities. This way, you can eliminate some of the background noise of measurements. | 7 | Physical Chemistry |
Since it is accepted that ion suppression has the potential to affect the other analytical parameters of any assay, a prudent approach to any LC-MS method development should include an evaluation of ion-suppression. There are two accepted protocols by which this may be achieved, described as follows. | 3 | Analytical Chemistry |
Receptor-activated G proteins are bound to the inner surface of the cell membrane. They consist of the G and the tightly associated G subunits.
There are four main families of G subunits: Gα (G stimulatory), Gα (G inhibitory), Gα, and Gα. They behave differently in the recognition of the effector molecule, but share a similar mechanism of activation. | 1 | Biochemistry |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13. | 1 | Biochemistry |
There are a number of ways to measure ocean turbidity, including autonomous remote vehicles, shipcasts and satellites.
From a satellite, a proxy measurement of the water turbidity can be made by examining the amount of reflectance in the visible region of the electromagnetic spectrum. For the Advanced Very High Resolution Radiometer (AVHRR), the logical choice is band 1, covering wavelengths 580 to 680 nanometres, the orange and red. In order to make derived products that are comparable over time and space, an atmospheric correction is required. To do this, the effects of Rayleigh scattering are calculated based on the satellite viewing angle and the solar zenith angle and then subtracted from the band 1 radiance. For an aerosol correction, band 2 in the near infrared is used. It is first corrected for Rayleigh scattering and then subtracted from the Rayleigh corrected band 1. The Rayleigh corrected band 2 is assumed to be aerosol radiance because no return signal from water in the near infrared is expected since water is highly absorbing at those wavelengths. Because bands 1 and 2 are relatively close on the electromagnetic spectrum, we can reasonably assume their aerosol radiances are the same.
In these images the turbidity is quantified as the percent reflected light emerging from the water column in a range of 0 to 8 percent. The reflectance percentage can be correlated to attenuation, Secchi disk depth or total suspended solids although the exact relationship will vary regionally and depends on the optical properties of the water. For example, in Florida Bay, 10% reflectance corresponds to a sediment concentration of 30 milligram/litre and a Secchi depth of 0.5 metre. These relationships are approximately linear so that 5% reflectance would correspond to a sediment concentration of approximately 15 milligram/litre and a Secchi depth of 1 metre. In the Mississippi River plume regions these same reflectance values would represent sediment concentrations that are about ten times or more higher. | 3 | Analytical Chemistry |
Deoxyguanosine monophosphate (dGMP), also known as deoxyguanylic acid or deoxyguanylate in its conjugate acid and conjugate base forms, respectively, is a derivative of the common nucleic acid guanosine triphosphate (GTP), in which the –OH (hydroxyl) group on the 2 carbon on the nucleotides pentose has been reduced to just a hydrogen atom (hence the "deoxy-" part of the name). It is used as a monomer in DNA. | 1 | Biochemistry |
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. | 1 | Biochemistry |
When most materials are electrically polarized, the polarization induced, P, is almost exactly proportional to the applied external electric field E; so the polarization is a linear function. This is called linear dielectric polarization (see figure). Some materials, known as paraelectric materials, show a more enhanced nonlinear polarization (see figure). The electric permittivity, corresponding to the slope of the polarization curve, is not constant as in linear dielectrics but is a function of the external electric field.
In addition to being nonlinear, ferroelectric materials demonstrate a spontaneous nonzero polarization (after entrainment, see figure) even when the applied field E is zero. The distinguishing feature of ferroelectrics is that the spontaneous polarization can be reversed by a suitably strong applied electric field in the opposite direction; the polarization is therefore dependent not only on the current electric field but also on its history, yielding a hysteresis loop. They are called ferroelectrics by analogy to ferromagnetic materials, which have spontaneous magnetization and exhibit similar hysteresis loops.
Typically, materials demonstrate ferroelectricity only below a certain phase transition temperature, called the Curie temperature (T) and are paraelectric above this temperature: the spontaneous polarization vanishes, and the ferroelectric crystal transforms into the paraelectric state. Many ferroelectrics lose their pyroelectric properties above T completely, because their paraelectric phase has a centrosymmetric crystal structure. | 7 | Physical Chemistry |
Scientific works are normally published in peer-reviewed journals, but He failed to do so regarding the birth of gene-edited babies. This was one of the grounds on which He was criticized. It was later reported that He did submit two manuscripts to Nature and the Journal of the American Medical Association, which were both rejected, mainly on ethical issues. Hes first manuscript titled "Birth of Twins After Genome Editing for HIV Resistance" was submitted to Nature on 19 November. He shared copies of the manuscript to the Associated Press, which he further allowed to document his works. In an interview, Hurlbut opined that the condemnation of Hes work would have been less harsh if the study had been published, and said, "If it had been published, the publishing process itself would have brought a level of credibility because of the normal scrutiny involved; the data analysis would have been vetted."
The scientific manuscripts of He were revealed when an anonymous source sent them to the MIT Technology Review, which reported them on 3 December 2019. | 1 | Biochemistry |
Discovered in 1937 by Robin Hill, Hill reagents allowed the discovery of electron transport chains during photosynthesis.
These are dyes that act as artificial electron acceptors, changing color when they are reduced.
An example of a Hill reagent is 2,6-dichlorophenolindophenol (DCPIP). | 5 | Photochemistry |
meta-Chloroperoxybenzoic acid (mCPBA or mCPBA) is a peroxycarboxylic acid. It is a white solid often used widely as an oxidant in organic synthesis. mCPBA is often preferred to other peroxy acids because of its relative ease of handling. mCPBA is a strong oxidizing agent that may cause fire upon contact with flammable material. | 0 | Organic Chemistry |
The appropriate halocarbyne precursors of choice can be reacted with organolithium reagents to afford the respective lithiocarbyne derivate by virtue of lithium/halogen exchange. This species can serve as a lynchpin for subsequent carbide linkage with an additional metal complex. Phosphine-based analogues were first introduced by Templeton and co. These types of complexes can be characterized crystallographically and are distinguishable by their C symmetry. | 0 | Organic Chemistry |
The Balliol-Trinity Laboratories in Oxford, England, was an early chemistry laboratory at the University of Oxford.
The laboratory was located between Balliol College and Trinity College, hence the name. It was especially known for physical chemistry.
Chemistry was first recognized as a separate discipline at Oxford University in the 19th century. From 1855, a chemistry laboratory existed in a basement at Balliol College. In 1879, Balliol and Trinity agreed to have a laboratory at the boundary of the two colleges. The laboratory became the strongest of the Oxford college research institutions in chemistry. It remained in operation until the Second World War when a new Physical Chemistry Laboratory (PCL) was constructed by Oxford University in the Science Area. | 7 | Physical Chemistry |
While tartaric acid is well-tolerated by humans and lab animals, an April 2021 letter to the editor of JAVMA hypothesized that the tartaric acid in grapes could be the cause of grape and raisin toxicity in dogs.
In dogs, the tartaric acid of tamarind causes acute kidney injury, which can often be fatal. | 4 | Stereochemistry |
A few Gram-positive bacteria are intrinsically resistant to vancomycin: Leuconostoc and Pediococcus species, but these organisms rarely cause diseases in humans. Most Lactobacillus species are also intrinsically resistant to vancomycin, with the exception of L. acidophilus and L. delbrueckii, which are sensitive. Other Gram-positive bacteria with intrinsic resistance to vancomycin include Erysipelothrix rhusiopathiae, Weissella confusa, and Clostridium innocuum.
Most Gram-negative bacteria are intrinsically resistant to vancomycin because their outer membranes are impermeable to large glycopeptide molecules (with the exception of some non-gonococcal Neisseria species). | 0 | Organic Chemistry |
Frémy's salt is prepared from hydroxylaminedisulfonic acid. Oxidation of the conjugate base gives the purple dianion:
:HON(SOH) → [HON(SO)] + 2 H
:2 [HON(SO)] + PbO → 2 [ON(SO)] + PbO + HO
The synthesis can be performed by combining nitrite and bisulfite to give the hydroxylaminedisulfonate. Oxidation is typically conducted at low-temperature, either chemically or by electrolysis.
Other reactions:
: HNO + 2 → + HO
: 3 + + H → 3 + MnO + 2 HO
: 2 + 4 K → K[ON(SO)] | 0 | Organic Chemistry |
Bicyclic molecules are described by IUPAC nomenclature. The root of the compound name depends on the total number of atoms in all rings together, possibly followed by a suffix denoting the functional group with the highest priority. Numbering of the carbon chain always begins at one bridgehead atom (where the rings meet) and follows the carbon chain along the longest path, to the next bridgehead atom. Then numbering is continued along the second longest path and so on. Fused and bridged bicyclic compounds get the prefix bicyclo, whereas spirocyclic compounds get the prefix spiro. In between the prefix and the suffix, a pair of brackets with numerals denotes the number of carbon atoms between each of the bridgehead atoms. These numbers are arranged in descending order and are separated by periods.
For example, the carbon frame of norbornane contains a total of 7 atoms, hence the root name heptane. This molecule has two paths of 2 carbon atoms and a third path of 1 carbon atom between the two bridgehead carbons, so the brackets are filled in descending order: [2.2.1]. Addition of the prefix bicyclo gives the total name bicyclo[2.2.1]heptane.
The carbon frame of camphor also counts 7 atoms, but is substituted with a carbonyl in this case, hence the suffix heptanone. We start with numbering the carbon frame at the bridgehead atom with the highest priority (methyl goes before proton), hence the bridgehead carbon in front gets number 1, the carbonyl gets number 2 and numbering continues along the carbon chain following the longest path, until the doubly substituted top carbon (number 7). Equal to norbornane, this molecule also has two paths of 2 carbon atoms and one path of 1 carbon atom between the two bridgehead carbons, so the numbers within the brackets stay [2.2.1]. Combining the brackets and suffix (now filling in the position of the carbonyl as well) gives us [2.2.1]heptan-2-one. Besides bicyclo, the prefix should also specify the positions of all methyl substituents so the complete, official name becomes 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one.
When naming simple fused bicyclic compounds, the same method as for bridged bicyclic compounds is applied, except the third path between the two bridgehead atoms now consists of zero atoms. Therefore, fused bicyclic compounds have a "0" included in the brackets. For example, decalin is named bicyclo[4.4.0]decane. The numbers are sometimes omitted in unambiguous cases. For example, bicyclo[1.1.0]butane is typically called simply bicyclobutane.
The heterocyclic molecule DABCO has a total of 8 atoms in its bridged structure, hence the root name octane. Here the two bridgehead atoms are nitrogen instead of carbon atoms. Therefore, the official name gets the additional prefix 1,4-diaza and the total name becomes 1,4-diazabicyclo[2.2.2]octane. | 4 | Stereochemistry |
He obtained both his diploma and PhD (first synthesis of Kekulene) from the University of Heidelberg in 1977 and 1979, respectively. | 0 | Organic Chemistry |
In genetics and bioinformatics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold.
For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles.
SNPs can help explain differences in susceptibility to a wide range of diseases across a population. For example, a common SNP in the CFH gene is associated with increased risk of age-related macular degeneration. Differences in the severity of an illness or response to treatments may also be manifestations of genetic variations caused by SNPs. For example, two common SNPs in the APOE gene, rs429358 and rs7412, lead to three major APO-E alleles with different associated risks for development of Alzheimer's disease and age at onset of the disease.
Single nucleotide substitutions with an allele frequency of less than 1% are sometimes called single-nucleotide variants (SNVs). "Variant" may also be used as a general term for any single nucleotide change in a DNA sequence, encompassing both common SNPs and rare mutations, whether germline or somatic. The term SNV has therefore been used to refer to point mutations found in cancer cells. DNA variants must also commonly be taken into consideration in molecular diagnostics applications such as designing PCR primers to detect viruses, in which the viral RNA or DNA sample may contain SNVs. However, this nomenclature uses arbitrary distinctions (such as an allele frequency of 1%) and is not used consistently across all fields; the resulting disagreement has prompted calls for a more consistent framework for naming differences in DNA sequences between two samples. | 1 | Biochemistry |
Surveys showed that 54% of lakes in Asia are eutrophic; in Europe, 53%; in North America, 48%; in South America, 41%; and in Africa, 28%. In South Africa, a study by the CSIR using remote sensing has shown more than 60% of the reservoirs surveyed were eutrophic.
The World Resources Institute has identified 375 hypoxic coastal zones in the world, concentrated in coastal areas in Western Europe, the Eastern and Southern coasts of the US, and East Asia, particularly Japan. | 2 | Environmental Chemistry |
A [1,j]-sigmatropic rearrangement is also a two component pericyclic reaction: one component is the π-system, the other component is the migrating group. The simplest case is a [1,j]-hydride shift across a π-system where j is odd. In this case, as the hydrogen has only a spherically symmetric s orbital, the reaction must be suprafacial with respect to the hydrogen. The total number of electrons involved is (j + 1) as there are (j − 1)/2 π-bond plus the σ bond involved in the reaction. If j = 4n − 1 then it must be antarafacial, and if j = 4n + 1, then it must be suprafacial. This agrees with experiment that [1,3]-hydride shifts are generally not observed as the symmetry-allowed antarafacial process is not feasible, but [1,5]-hydride shifts are quite facile.
For a [1,j]-alkyl shift, where the reaction can be antarafacial (i.e. invert stereochemistry) with respect to the carbon center, the same rules apply. If j = 4n − 1 then the reaction is symmetry-allowed if it is either antarafacial with respect to the π-system, or inverts stereochemistry at the carbon. If j = 4n + 1 then the reaction is symmetry-allowed if it is suprafacial with respect to the π-system and retains stereochemistry at the carbon center.
On the right is one of the first examples of a [1,3]-sigmatropic shift to be discovered, reported by Berson in 1967. In order to allow for inversion of configuration, as the σ bond breaks, the C(H)(D) moiety twists around at the transition state, with the hybridization of the carbon approximating sp, so that the remaining unhybridized p orbital maintains overlap with both carbons 1 and 3. | 7 | Physical Chemistry |
London dispersion forces arise from instantaneous dipoles between two nonpolar molecules close together. The random nature of electron orbit allows moments in which the charge distribution in a molecule is unevenly distributed, allowing an electrostatic attraction to another molecule with a temporary dipole. A larger molecule allows for a larger dipole, and thus will have stronger dispersion forces. | 6 | Supramolecular Chemistry |
In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets. Where these triplets equate to amino acids or stop signals during translation, they are called codons.
A single strand of a nucleic acid molecule has a phosphoryl end, called the 5′-end, and a hydroxyl or 3′-end. These define the 5′→3′ direction. There are three reading frames that can be read in this 5′→3′ direction, each beginning from a different nucleotide in a triplet. In a double stranded nucleic acid, an additional three reading frames may be read from the other, complementary strand in the 5′→3′ direction along this strand. As the two strands of a double-stranded nucleic acid molecule are antiparallel, the 5′→3′ direction on the second strand corresponds to the 3′→5′ direction along the first strand.
In general, at the most, one reading frame in a given section of a nucleic acid, is biologically relevant (open reading frame). Some viral transcripts can be translated using multiple, overlapping reading frames. There is one known example of overlapping reading frames in mammalian mitochondrial DNA: coding portions of genes for 2 subunits of ATPase overlap. | 1 | Biochemistry |
Formally, amidines are a class of oxoacids. The oxoacid from which an amidine is derived must be of the form RE(=O)OH, where R is a substituent. The −OH group is replaced by an −NH group and the =O group is replaced by =NR, giving amidines the general structure RE(=NR)NR. When the parent oxoacid is a carboxylic acid, the resulting amidine is a carboxamidine or carboximidamide (IUPAC name). Carboxamidines are frequently referred to simply as amidines, as they are the most commonly encountered type of amidine in organic chemistry. | 0 | Organic Chemistry |
The concentration of CDOM can have a significant effect on biological activity in aquatic systems. CDOM diminishes light intensity as it penetrates water. Very high concentrations of CDOM can have a limiting effect on photosynthesis and inhibit the growth of phytoplankton, which form the basis of oceanic food chains and are a primary source of atmospheric oxygen. However, the influence of CDOM on algal photosynthesis can be complex in other aquatic systems like lakes where CDOM increases photosynthetic rates at low and moderate concentrations, but decreases photosynthetic rates at high concentrations. CDOM concentrations reflect hierarchical controls. Concentrations vary among lakes in close proximity due to differences in lake and watershed morphometry, and regionally because of difference in climate and dominant vegetation. CDOM also absorbs harmful UVA/B radiation, protecting organisms from DNA damage.
Absorption of UV radiation causes CDOM to "bleach", reducing its optical density and absorptive capacity. This bleaching (photodegradation) of CDOM produces low-molecular-weight organic compounds which may be utilized by microbes, release nutrients that may be used by phytoplankton as a nutrient source for growth, and generates reactive oxygen species, which may damage tissues and alter the bioavailability of limiting trace metals.
CDOM can be detected and measured from space using satellite remote sensing and often interferes with the use of satellite spectrometers to remotely estimate phytoplankton populations. As a pigment necessary for photosynthesis, chlorophyll is a key indicator of the phytoplankton abundance. However, CDOM and chlorophyll both absorb light in the same spectral range so it is often difficult to differentiate between the two.
Although variations in CDOM are primarily the result of natural processes including changes in the amount and frequency of precipitation, human activities such as logging, agriculture, effluent discharge, and wetland drainage can affect CDOM levels in fresh water and estuarine systems. | 0 | Organic Chemistry |
Since its first inception in 1967, many synthesis techniques have been developed and employed for the polymerization of o-phthalaldehyde. Most notably, living polymerization methods are among the most common and promising techniques used, as can be seen in the high number of publications in the literature depicting their usage in poly(phthalaldehyde) preparation. | 7 | Physical Chemistry |
A sulfur-based main group analog of a carbyne complex has been prepared by Seppalt and coworkers. The compound, trifluoro(2,2,2-trifluoroethylidyne)-λ-sulfurane, FC–C≡SF, prepared by dehydrofluorination of FC–CH=SF or FC–CH–SF, is an unstable gas that readily undergoes dimerization to form trans-(CF)(SF)C=C(CF)(SF) at above –50 °C. | 0 | Organic Chemistry |
A base metal, such as iron (Fe) goes into aqueous solution as positively charged cation, Fe. As the metal is oxidized under anaerobic conditions by the protons of water, H ions are reduced to form molecular H. This can be written in the following ways under acidic and neutral conditions respectively:
:Fe + 2 H → Fe + H
:Fe + 2 HO → Fe(OH) + H
Usually, a thin film of molecular hydrogen forms on the metal. Sulfate-reducing bacteria oxidize the molecular hydrogen to produce hydrogen sulfide ions (HS) and water:
:4 H + SO → HS + 3 HO + OH
The iron ions partly precipitate to form iron (II) sulfide. Another reaction occurs between iron and water producing iron hydroxide.
:Fe + HS → FeS + H
:3 Fe + 6 HO → 3 Fe(OH) + 6 H
The net equation comes to:
:4 Fe + SO + H + 3 HO → FeS + 3 Fe(OH) + OH
This form of corrosion by sulfate-reducing bacteria can, in this way, be far more harmful than anaerobic corrosion. | 8 | Metallurgy |
A ChemFET is a chemically-sensitive field-effect transistor, that is a field-effect transistor used as a sensor for measuring chemical concentrations in solution. When the target analyte concentration changes, the current through the transistor will change accordingly. Here, the analyte solution separates the source and gate electrodes. A concentration gradient between the solution and the gate electrode arises due to a semi-permeable membrane on the FET surface containing receptor moieties that preferentially bind the target analyte. This concentration gradient of charged analyte ions creates a chemical potential between the source and gate, which is in turn measured by the FET. | 7 | Physical Chemistry |
Depolarization is essential to the functions of many cells in the human body, which is exemplified by the transmission of stimuli both within a neuron and between two neurons. The reception of stimuli, neural integration of those stimuli, and the neuron's response to stimuli all rely upon the ability of neurons to utilize depolarization to transmit stimuli either within a neuron or between neurons. | 7 | Physical Chemistry |
Non-biologic surface coatings will occur via two mechanisms, the first being direct hydrophobic interaction of the lipid tail with a hydrophobic surface resulting in a monolayer of FSL at the surface. The second surface coating will be through the formation of bilayers, which probably either encapsulate fibres or being via the hydrophilic F group. This is the expected mechanism by which FSLs bind to fibrous membranes such as paper and glass fibres. A recent study has found that when FSL Kode constructs are optimised, could in a few seconds glycosylate almost any non-biological surface including metals, glass, plastics, rubbers, and other polymers. | 1 | Biochemistry |
There are many situations where prediction of partition coefficients prior to experimental measurement is useful. For example, tens of thousands of industrially manufactured chemicals are in common use, but only a small fraction have undergone rigorous toxicological evaluation. Hence there is a need to prioritize the remainder for testing. QSAR equations, which in turn are based on calculated partition coefficients, can be used to provide toxicity estimates. Calculated partition coefficients are also widely used in drug discovery to optimize screening libraries and to predict druglikeness of designed drug candidates before they are synthesized. As discussed in more detail below, estimates of partition coefficients can be made using a variety of methods, including fragment-based, atom-based, and knowledge-based that rely solely on knowledge of the structure of the chemical. Other prediction methods rely on other experimental measurements such as solubility. The methods also differ in accuracy and whether they can be applied to all molecules, or only ones similar to molecules already studied. | 7 | Physical Chemistry |
A shape resonance is a metastable state in which an electron is trapped due to the shape of a potential barrier.
Altunata describes a state as being a shape resonance if, "the internal state of the system remains unchanged upon disintegration of the quasi-bound level."
A more general discussion of resonances and their taxonomies in molecular system can be found in the review article by Schulz,; for the discovery of the Fano resonance line-shape and for the Majorana pioneering work in this field by Antonio Bianconi; and for
a mathematical review by Combes et al. | 7 | Physical Chemistry |
α-Ketovaleric acid is a keto acid that is found in human blood. Unlike related keto acids, it is not an intermediate or metabolite associated with amino acids and its origin is unknown. | 1 | Biochemistry |
Nitrite is detected and analyzed by the formation of a red pink colour upon treatment of a nitrite-containing sample with the Griess reagent, which consists of two components in an acidic solution: an aniline derivative and a coupling agent. The most common arrangements use sulfanilamide and N-(1-naphthyl)ethylenediamine: a typical commercial Griess reagent contains 0.2% N-(1-naphthyl)ethylenediamine dihydrochloride, and 2% sulfanilamide in 5% phosphoric acid. This diamine is used in place of the simpler and cheaper 1-naphthylamine because the latter is a potent carcinogen and moreover the diamine forms a more polar and hence a much more soluble dye in acidic aqueous medium. Other aniline derivatives that have been used include sulfanilic acid, nitroaniline, and p-aminoacetophenone.
The Griess test involves two subsequent reactions. When sulfanilamide is added, the nitrite ion reacts with it in the Griess diazotization reaction to form a diazonium salt, which then reacts with N-(1-naphthyl)ethylenediamine in an azo coupling reaction, forming a pink-red azo dye.
Using a spectrophotometer, it is possible to quantitatively determine the nitrite concentration. The detection limit of the Griess test generally ranges between 0.02 and 2 μM, depending on the exact details of the specific components used in the Griess reagent. | 3 | Analytical Chemistry |
MFGM lipid components such as sphingolipids are involved in the intestinal uptake of cholesterol. Studies in adult rodents have shown that milk sphingomyelin could lower the intestinal absorption of cholesterol in a dose-dependent manner. Intestinal cholesterol absorption in adult rodents consuming a high fat diet was limited by sphingomyelin supplementation. Milk sphingomyelin and other phospholipids with high affinity for cholesterol could limit the micellar solubility of intestinal cholesterol, thereby limiting the cholesterol uptake by the enterocyte. Dietary sphingolipids have been shown to dose-dependently lower plasma cholesterol and triacylglycerol in adult rodents fed with Western-type diet and protect the liver from fat- and cholesterol-induced steatosis. Dietary sphingolipids also lowers hepatic cholesterol and triglyceride levels in adult rodents partly by modulating hepatic gene expression. | 1 | Biochemistry |
Pyramidal inversion in nitrogen and amines is known as nitrogen inversion. It is a rapid oscillation of the nitrogen atom and substituents, the nitrogen "moving" through the plane formed by the substituents (although the substituents also move - in the other direction); the molecule passing through a planar transition state. For a compound that would otherwise be chiral due to a nitrogen stereocenter, nitrogen inversion provides a low energy pathway for racemization, usually making chiral resolution impossible. | 4 | Stereochemistry |
In eukaryotes, ribosomal rRNA and the tRNAs involved in translation are controlled by RNA polymerase I (Pol I) and RNA polymerase III (Pol III) . RNA Polymerase II (Pol II) is responsible for the production of messenger RNA (mRNA) within the cell. Particularly for Pol II, much of the regulatory checkpoints in the transcription process occur in the assembly and escape of the pre-initiation complex. A gene-specific combination of transcription factors will recruit TFIID and/or TFIIA to the core promoter, followed by the association of TFIIB, creating a stable complex onto which the rest of the General Transcription Factors (GTFs) can assemble. This complex is relatively stable, and can undergo multiple rounds of transcription initiation.
After the binding of TFIIB and TFIID, Pol II the rest of the GTFs can assemble. This assembly is marked by the post-translational modification (typically phosphorylation) of the C-terminal domain (CTD) of Pol II through a number of kinases. The CTD is a large, unstructured domain extending from the RbpI subunit of Pol II, and consists of many repeats of the heptad sequence YSPTSPS. TFIIH, the helicase that remains associated with Pol II throughout transcription, also contains a subunit with kinase activity which will phosphorylate the serines 5 in the heptad sequence. Similarly, both CDK8 (a subunit of the massive multiprotein Mediator complex) and CDK9 (a subunit of the p-TEFb elongation factor), have kinase activity towards other residues on the CTD. These phosphorylation events promote the transcription process and serve as sites of recruitment for mRNA processing machinery. All three of these kinases respond to upstream signals, and failure to phosphorylate the CTD can lead to a stalled polymerase at the promoter. | 1 | Biochemistry |
Precipitation and surface water leaches dissolved organic carbon (DOC) from vegetation and plant litter and percolates through the soil column to the saturated zone. The concentration, composition, and bioavailability of DOC are altered during transport through the soil column by various physicochemical and biological processes, including sorption, desorption, biodegradation and biosynthesis. Hydrophobic molecules are preferentially partitioned onto soil minerals and have a longer retention time in soils than hydrophilic molecules. The hydrophobicity and retention time of colloids and dissolved molecules in soils are controlled by their size, polarity, charge, and bioavailability. Bioavailable DOM is subjected to microbial decomposition, resulting in a reduction in size and molecular weight. Novel molecules are synthesized by soil microbes, and some of these metabolites enter the DOC reservoir in groundwater. | 2 | Environmental Chemistry |
Carbon sequestration - when acting as a carbon sink - helps to mitigate climate change and thus reduce harmful effects of climate change. It helps to slow the atmospheric and marine accumulation of greenhouse gases, which are released by burning fossil fuels and industrial livestock production.
Carbon sequestration, when applied for climate change mitigation, can either build on enhancing naturally occurring carbon sequestration or use technology for carbon sequestration processes.
Within the carbon capture and storage approaches, carbon sequestration refers to the storage component. Artificial carbon storage technologies can be applied, such as gaseous storage in deep geological formations (including saline formations and exhausted gas fields), and solid storage by reaction of CO with metal oxides to produce stable carbonates.
For carbon to be sequestered artificially (i.e. not using the natural processes of the carbon cycle) it must first be captured, or it must be significantly delayed or prevented from being re-released into the atmosphere (by combustion, decay, etc.) from an existing carbon-rich material, by being incorporated into an enduring usage (such as in construction). Thereafter it can be passively stored or remain productively utilized over time in a variety of ways. For instance, upon harvesting, wood (as a carbon-rich material) can be incorporated into construction or a range of other durable products, thus sequestering its carbon over years or even centuries. | 5 | Photochemistry |
Methylene iodide and two equivalents of ethyl acetoacetate react in the presence of sodium methoxide to form the diethyl ester of 2,4-diacetyl pentane. This precursor is treated with base to induce cyclization. Finally, heat is applied to generate Hagemann's ester. | 0 | Organic Chemistry |
* M.J.R Cantow Polymer Fractionation Academic Press, New York (1967)
* L.H. Tung Fractionation of Synthetic Polymers Marcel Dekker, New York (1977)
* F. Francuskiewicz Polymer Fractionation Springer, Berlin (1994)
* R. Koningsveld, L.D. Kleintjens, H. Geerissen, P. Schützeichel, B.A. Wolf „Fractionation“ in: Comprehensive Polymer Science Volume 1 Pergamon Press, Oxford (1989) 293-312 | 7 | Physical Chemistry |
The standard enthalpy change of any reaction can be calculated from the standard enthalpies of formation of reactants and products using Hesss law. A given reaction is considered as the decomposition of all reactants into elements in their standard states, followed by the formation of all products. The heat of reaction is then minus the sum of the standard enthalpies of formation of the reactants (each being multiplied by its respective stoichiometric coefficient, ) plus' the sum of the standard enthalpies of formation of the products (each also multiplied by its respective stoichiometric coefficient), as shown in the equation below:
If the standard enthalpy of the products is less than the standard enthalpy of the reactants, the standard enthalpy of reaction is negative. This implies that the reaction is exothermic. The converse is also true; the standard enthalpy of reaction is positive for an endothermic reaction. This calculation has a tacit assumption of ideal solution between reactants and products where the enthalpy of mixing is zero.
For example, for the combustion of methane, :
However is an element in its standard state, so that , and the heat of reaction is simplified to
which is the equation in the previous section for the enthalpy of combustion . | 7 | Physical Chemistry |
The genomes of Melainabacteria organisms isolated from ground water indicate that the organism has the capacity to fix nitrogen. Melainabacteria lack linked electron transport chains but have multiple methods to generate a membrane potential which can then produce ATP via ATP synthase. They are able to use Fe hydrogenases for production that can be consumed by other microorganisms. Melainabacteria from the human gut also synthesize several B and K vitamins, which suggests that these bacteria are beneficial to their host because they are consumed along with plant fibers. | 2 | Environmental Chemistry |
In order to get a good quality product, removing the inclusion becomes necessary. Liquid metal filtration through a ceramic medium is an efficient way to clean the metal. Different types of ceramic media are used in-line in foundries, such as ceramic foam filters, porous tube filters, bonded ceramic filters, and deep bed filters. | 8 | Metallurgy |
Monosaccharides (from Greek monos: single, sacchar: sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built. Simply, this is the structural unit of carbohydrates.
They are usually colorless, water-soluble, and crystalline organic solids. Contrary to their name (sugars), only some monosaccharides have a sweet taste. Most monosaccharides have the formula (CHO) (though not all molecules with this formula are monosaccharides).
Examples of monosaccharides include glucose (dextrose), fructose (levulose), and galactose. Monosaccharides are the building blocks of disaccharides (such as sucrose, lactose and maltose) and polysaccharides (such as cellulose and starch). The table sugar used in everyday vernacular is itself a disaccharide sucrose comprising one molecule of each of the two monosaccharides -glucose and -fructose.
Each carbon atom that supports a hydroxyl group is chiral, except those at the end of the chain. This gives rise to a number of isomeric forms, all with the same chemical formula. For instance, galactose and glucose are both aldohexoses, but have different physical structures and chemical properties.
The monosaccharide glucose plays a pivotal role in metabolism, where the chemical energy is extracted through glycolysis and the citric acid cycle to provide energy to living organisms. Maltose is the dehydration condensate of two glucose molecules. | 0 | Organic Chemistry |
During normal metabolism in humans approximately 20% of the 1,3BPG produced does not go any further in the glycolytic pathway. It is instead shunted through an alternate pathway involving the reduction of ATP in the red blood cells. During this alternate pathway it is made into a similar molecule called 2,3-bisphosphoglyceric acid (2,3BPG). 2,3BPG is used as a mechanism to oversee the efficient release of oxygen from hemoglobin. Levels of this 1,3BPG will raise in a patient's blood when oxygen levels are low as this is one of the mechanisms of acclimatization. Low oxygen levels trigger a rise in 1,3BPG levels which in turn raises the level of 2,3BPG which alters the efficiency of oxygen dissociation from hemoglobin. | 5 | Photochemistry |
Sickle-cell anemia is caused by a point mutation in the β-globin chain of hemoglobin, causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid valine at the sixth position.
The β-globin gene is found on the short arm of chromosome 11. The association of two wild-type α-globin subunits with two mutant β-globin subunits forms hemoglobin S (HbS). Under low-oxygen conditions (being at high altitude, for example), the absence of a polar amino acid at position six of the β-globin chain promotes the non-covalent polymerisation (aggregation) of hemoglobin, which distorts red blood cells into a sickle shape and decreases their elasticity.
Hemoglobin is a protein found in red blood cells, and is responsible for the transportation of oxygen through the body. There are two subunits that make up the hemoglobin protein: beta-globins and alpha-globins.
Beta-hemoglobin is created from the genetic information on the HBB, or "hemoglobin, beta" gene found on chromosome 11p15.5. A single point mutation in this polypeptide chain, which is 147 amino acids long, results in the disease known as Sickle Cell Anemia.
Sickle-cell anemia is an autosomal recessive disorder that affects 1 in 500 African Americans, and is one of the most common blood disorders in the United States. The single replacement of the sixth amino acid in the beta-globin, glutamic acid, with valine results in deformed red blood cells. These sickle-shaped cells cannot carry nearly as much oxygen as normal red blood cells and they get caught more easily in the capillaries, cutting off blood supply to vital organs. The single nucleotide change in the beta-globin means that even the smallest of exertions on the part of the carrier results in severe pain and even heart attack. Below is a chart depicting the first thirteen amino acids in the normal and abnormal sickle cell polypeptide chain. | 1 | Biochemistry |
The slightly kinked diagonal line on the main part of the map is known as the surge (or stall) line. Above this line is a region of unstable flow, which is an area best avoided.
A compressor surge or compressor stall causes an abrupt reversal of airflow in the compressor. Compressor blades create a pumping action by working as airfoils. In a surge or stall, blades experience an aerodynamic stall (similar to an aircraft wing stalling) and become unable to hold back the higher pressure downstream, with a resulting violent flow reversal. The flame which is normally confined in the combustion chamber may come out of the engine inlet as well as the exhaust nozzle. | 7 | Physical Chemistry |
In 2013, Russia and China banned ractopamine in pork, and Russia also in beef, deeming it unfit for human consumption. Because the traditional Chinese diet embraces pig offal, and because ractopamine is concentrated by the gastro-intestinal system of animals, Chinese officials have banned ractopamine. Other countries in Asia, whose traditional diet is similar to that of the Chinese, have had similar concerns, but the American use of tied trade access as a proxy for conflict has somewhat mitigated their reactions. | 4 | Stereochemistry |
SDS is not carcinogenic in low concentrations according to some studies. Like all detergents, sodium lauryl sulfate removes oils from the skin, and can cause skin and eye irritation. It has been shown to irritate the skin of the face, with prolonged and constant exposure (more than an hour) in young adults. SDS may worsen skin problems in individuals with chronic skin hypersensitivity, with some people being affected more than others. | 1 | Biochemistry |
Nuclear pre-mRNA introns (spliceosomal introns) are characterized by specific intron sequences located at the boundaries between introns and exons. These sequences are recognized by spliceosomal RNA molecules when the splicing reactions are initiated. In addition, they contain a branch point, a particular nucleotide sequence near the 3 end of the intron that becomes covalently linked to the 5 end of the intron during the splicing process, generating a branched intron. Apart from these three short conserved elements, nuclear pre-mRNA intron sequences are highly variable. Nuclear pre-mRNA introns are often much longer than their surrounding exons. | 1 | Biochemistry |
A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. Nonsynonymous substitutions differ from synonymous substitutions, which do not alter amino acid sequences and are (sometimes) silent mutations. As nonsynonymous substitutions result in a biological change in the organism, they are subject to natural selection.
Nonsynonymous substitutions at a certain locus can be compared to the synonymous substitutions at the same locus to obtain the K/K ratio. This ratio is used to measure the evolutionary rate of gene sequences. If a gene has lower levels of nonsynonymous than synonymous nucleotide substitution, then it can be inferred to be functional because a K/K ratio < 1 is a hallmark of sequences that are being constrained to code for proteins.
Nonsynonymous substitutions are also referred to as replacement mutations. | 1 | Biochemistry |
Concrete exposed to seawater is susceptible to its corrosive effects. The effects are more pronounced above the tidal zone than where the concrete is permanently submerged. In the submerged zone, magnesium and hydrogen carbonate ions precipitate a layer of brucite (magnesium hydroxide: Mg(OH)), about 30 micrometers thick, on which a slower deposition of calcium carbonate as aragonite occurs. These mineral layers somewhat protect the concrete from other processes, which includes attack by magnesium, chloride and sulfate ions and carbonatation. Above the water surface, mechanical damage may occur by erosion by waves themselves or sand and gravel they carry, and by crystallization of salts from water soaking into the concrete pores and then drying up. Pozzolanic cements and cements using more than of blast furnace slags as cementitious material are more resistant to seawater than pure Portland cement. Seawater attack presents aspects of both chloride and sulfate attacks. | 8 | Metallurgy |
Uridine diphosphate galactose (UDP-galactose) is an intermediate in the production of polysaccharides. It is important in nucleotide sugars metabolism, and is the substrate for the transferase B4GALT5. | 1 | Biochemistry |
Lohr and coworkers (2001) report that in a comprehensive study of pancreatic secretions of individuals without pancreatic carcinoma, p53 mutations could be found in the pancreatic juices of a small percentage of participants. Because mutations of p53 has been extensively found in pancreatic carcinomas, the researchers for this investigation were attempting to determine if the mutation itself can be linked to the development of pancreatic cancer. While Lohr was able to find p53 mutations via TGGE in a few subjects, none subsequently developed pancreatic carcinoma. Thus, the researchers conclude by noting that the p53 mutation may not be the sole indicator of pancreatic carcinoma oncogenesis. | 1 | Biochemistry |
In organic chemistry, neighbouring group participation (NGP, also known as anchimeric assistance) has been defined by the International Union of Pure and Applied Chemistry (IUPAC) as the interaction of a reaction centre with a lone pair of electrons in an atom or the electrons present in a sigma or pi bond contained within the parent molecule but not conjugated with the reaction centre. When NGP is in operation it is normal for the reaction rate to be increased. It is also possible for the stereochemistry of the reaction to be abnormal (or unexpected) when compared with a normal reaction. While it is possible for neighbouring groups to influence many reactions in organic chemistry (e.g. the reaction of a diene such as 1,3-cyclohexadiene with maleic anhydride normally gives the endo isomer because of a secondary effect {overlap of the carbonyl group π orbitals with the transition state in the Diels-Alder reaction}) this page is limited to neighbouring group effects seen with carbocations and S2 reactions. | 7 | Physical Chemistry |
In physics, the signal might be a wave, such as an electromagnetic wave, an acoustic wave, or the vibration of a mechanism. The power spectral density (PSD) of the signal describes the power present in the signal as a function of frequency, per unit frequency. Power spectral density is commonly expressed in watts per hertz (W/Hz).
When a signal is defined in terms only of a voltage, for instance, there is no unique power associated with the stated amplitude. In this case "power" is simply reckoned in terms of the square of the signal, as this would always be proportional to the actual power delivered by that signal into a given impedance. So one might use units of V Hz for the PSD. Energy spectral density (ESD) would have units of V s Hz, since energy has units of power multiplied by time (e.g., watt-hour).
In the general case, the units of PSD will be the ratio of units of variance per unit of frequency; so, for example, a series of displacement values (in meters) over time (in seconds) will have PSD in units of meters squared per hertz, m/Hz.
In the analysis of random vibrations, units of g Hz are frequently used for the PSD of acceleration, where g denotes the g-force.
Mathematically, it is not necessary to assign physical dimensions to the signal or to the independent variable. In the following discussion the meaning of x(t) will remain unspecified, but the independent variable will be assumed to be that of time. | 7 | Physical Chemistry |
Photolysis is performed resulting in photoactivation of the TIVA tag in the target cell or cells. Specifically, uncaging of the TIVA tag is accomplished using a 405-nm laser while measuring FRET excited by 514 nm. During this process, the mRNA-capturing moiety is released and subsequently anneals to the poly(A) tail of cellular mRNA. To confirm that the cell is not damaged during photolysis, the cell is imaged with the confocal microscope. | 1 | Biochemistry |
The reactivity ratio of a growing copolymer chain terminating in a given monomer is the ratio of the reaction rate constant for addition of the same monomer and the rate constant for addition of the other monomer. That is, and , where for example is the rate constant for propagation of a polymer chain ending in monomer 1 (or A) by addition of monomer 2 (or B).
The composition and structural type of the copolymer depend on these reactivity ratios r and r according to the Mayo–Lewis equation, also called the copolymerization equation or copolymer equation, for the relative instantaneous rates of incorporation of the two monomers. | 7 | Physical Chemistry |
The Wulff construction is a method to determine the equilibrium shape of a droplet or crystal of fixed volume inside a separate phase (usually its saturated solution or vapor). Energy minimization arguments are used to show that certain crystal planes are preferred over others, giving the crystal its shape. | 7 | Physical Chemistry |
In friction stir processing (FSP), a rotating tool is used with a pin and a shoulder to a single piece of material to make specific property enhancement, such as improving the materials toughness or flexibility, in a specific area in the micro-structure of the material via fine grain of a second material with properties that improve the first.(Ma) Friction between the tool and workpieces results in localized heating that softens and plasticizes the workpiece. A volume of processed material is produced by movement of materials from the front of the pin to the back of the pin. During this process, the material undergoes intense plastic deformation and this results in significant grain refinement. (Mishra) FSP changes physical properties without changing physical state which helps engineers create things such as “high-strain-rate superplasticity”. The grain refinement occurs on the base material improving properties of the first material, while mixing with the second material. This allows for a variety of materials to be altered to be changed for things that may require other difficult to acquire conditions. The processes branches off of friction stir welding (FSW) which uses the same process to weld two pieces of different materials together without heating, melting, or having to change the materials physical state. | 8 | Metallurgy |
* As with all carbonyl compounds, the protons on the α-carbon are labile due to keto–enol tautomerization. Thus, the α-carbon is easily halogenated in the Hell–Volhard–Zelinsky halogenation.
* The Schmidt reaction converts carboxylic acids to amines.
* Carboxylic acids are decarboxylated in the Hunsdiecker reaction.
* The Dakin–West reaction converts an amino acid to the corresponding amino ketone.
* In the Barbier–Wieland degradation, a carboxylic acid on an aliphatic chain having a simple methylene bridge at the alpha position can have the chain shortened by one carbon. The inverse procedure is the Arndt–Eistert synthesis, where an acid is converted into acyl halide, which is then reacted with diazomethane to give one additional methylene in the aliphatic chain.
* Many acids undergo oxidative decarboxylation. Enzymes that catalyze these reactions are known as carboxylases (EC 6.4.1) and decarboxylases (EC 4.1.1).
* Carboxylic acids are reduced to aldehydes via the ester and DIBAL, via the acid chloride in the Rosenmund reduction and via the thioester in the Fukuyama reduction.
* In ketonic decarboxylation carboxylic acids are converted to ketones.
* Organolithium reagents (>2 equiv) react with carboxylic acids to give a dilithium 1,1-diolate, a stable tetrahedral intermediate which decomposes to give a ketone upon acidic workup.
* The Kolbe electrolysis is an electrolytic, decarboxylative dimerization reaction. It gets rid of the carboxyl groups of two acid molecules, and joins the remaining fragments together. | 0 | Organic Chemistry |
Transferrin is a serum protein that carries iron through the bloodstream to the bone marrow, where red blood cells are manufactured, as well as to the liver and spleen. Structurally, transferrin is a polypeptide with two N-linked polysaccharide chains. These polysaccharide chains are branched with sialic acid residues. Sialic acid is a monosaccharide carbohydrate.
Various forms of transferrin exist, with differing levels of sialylation. The most common form is tetrasialotransferrin, with four sialic acid chains. In persons who consume significant quantities of alcohol (usually more than 4 or 5 alcoholic beverages a day for two weeks or more) , the proportion of transferrin with zero, one, or two sialic acid chains is increased. These are referred to as carbohydrate-deficient transferrins. These carbohydrate-deficient transferrins can be measured in the bloodstream, and are important markers for alcohol use disorder. | 1 | Biochemistry |
Throughout the years there have been a few mass bleaching events that have affected the Great Barrier Reef. In particular, the years of 2016 and 2017, saw the reef sustain two years of back to back bleaching periods. This long period accounted for an estimated loss of half of the coral life in the Great Barrier Reef. The parts of the reef that did survive were damaged, leading to an overall period of low coral reproduction. This was later followed by another bleaching event in 2020, making it the third bleaching event in five years. Studies found however that the results of the 2020 bleaching were not too severe, as it only affected a minimal amount of reefs, with most being in the lower to moderate levels of bleaching.
In early 2022 a study showed, 91% of coral in the Great Barrier Reef, have experienced some degree of coral bleaching. The reefs that had higher levels of bleaching, often were accompanied by higher overall air temperature. These temperature levels lasted all through the summer season in Australia, attributing to prolonged coral bleaching periods. Prolonged periods raise concern, as corals would not be able to reproduce and die out, leading to more loss of the reefs. However, recent reports from June 2022, have stated that the Great Barrier Reef, is currently recovering. Reefs affected by bleaching have lowered to 16% along different areas of the Australian Coast. As ocean temperatures continue to drop, we can expect bleaching levels to go down, and coral levels to increase. Though coral bleaching has gone down, predators of the coral reef, Crown-of-thorns starfish, are still impacting coral growth and development. | 9 | Geochemistry |
Several methods exist to measure the inclusion content in liquid aluminium. The most common methods are PoDFA, Prefil, K-Mold and LiMCA. Measuring the inclusions is of great help to understand the impact of furnace preparation, alloying practice, feedstock mix, settling time, and similar parameters on melt cleanliness. | 8 | Metallurgy |
In marine systems DOC originates from either autochthonous or allochthonous sources. Autochthonous DOC is produced within the system, primarily by plankton organisms and in coastal waters additionally by benthic microalgae, benthic fluxes, and macrophytes, whereas allochthonous DOC is mainly of terrestrial origin supplemented by groundwater and atmospheric inputs. In addition to soil derived humic substances, terrestrial DOC also includes material leached from plants exported during rain events, emissions of plant materials to the atmosphere and deposition in aquatic environments (e.g., volatile organic carbon and pollens), and also thousands of synthetic human-made organic chemicals that can be measured in the ocean at trace concentrations.
Dissolved organic carbon (DOC) represents one of the Earth's major carbon pools. It contains a similar amount of carbon as the atmosphere and exceeds the amount of carbon bound in marine biomass by more than two-hundred times. DOC is mainly produced in the near-surface layers during primary production and zooplankton grazing processes. Other sources of marine DOC are dissolution from particles, terrestrial and hydrothermal vent input, and microbial production. Prokaryotes (bacteria and archaea) contribute to the DOC pool via release of capsular material, exopolymers, and hydrolytic enzymes, as well as via mortality (e.g. viral shunt). Prokaryotes are also the main decomposers of DOC, although for some of the most recalcitrant forms of DOC very slow abiotic degradation in hydrothermal systems or possibly sorption to sinking particles may be the main removal mechanism. Mechanistic knowledge about DOC-microbe-interactions is crucial to understand the cycling and distribution of this active carbon reservoir. | 2 | Environmental Chemistry |
Rate constants can be derived from the dataset published on the website [http://udfa.net]. Rate constants have the form:
k(T) = alpha*(T/300)*exp(-gamma/T)cms
The following table has the rate constants calculated for a typical temperature in a dense cloud T=10 K.
Formation rates r can be obtained using the rate constants k(T) and the abundances of the reactants species C and D:
r=k(T)[C][D]
where [Y] represents the abundance of the specie Y. In this approach, abundances were taken from The UMIST database for astrochemistry 2006, and the values are relatives to the H density. Following table shows the ratio r/r in order to get a view of the most important reactions.
The results suggest that (1a) reaction is the most prominent reaction in dense clouds. It is in concordance with Harju et al. 2000.
Next table shows the results by doing the same procedure for destruction reaction:
Results shows that, 1A reaction is the main sink for HO in dense clouds. | 2 | Environmental Chemistry |
In theoretical chemistry, a conjugated system is a system of connected p-orbitals with delocalized electrons in a molecule, which in general lowers the overall energy of the molecule and increases stability. It is conventionally represented as having alternating single and multiple bonds. Lone pairs, radicals or carbenium ions may be part of the system, which may be cyclic, acyclic, linear or mixed. The term "conjugated" was coined in 1899 by the German chemist Johannes Thiele.
Conjugation is the overlap of one p-orbital with another across an adjacent σ bond (in transition metals, d-orbitals can be involved).
A conjugated system has a region of overlapping p-orbitals, bridging the interjacent locations that simple diagrams illustrate as not having a π bond. They allow a delocalization of π electrons across all the adjacent aligned p-orbitals.
The π electrons do not belong to a single bond or atom, but rather to a group of atoms.
Molecules containing conjugated systems of orbitals and electrons are called conjugated molecules, which have overlapping p orbitals on three or more atoms. Some simple organic conjugated molecules are 1,3-butadiene, benzene, and allylic carbocations. The largest conjugated systems are found in graphene, graphite, conductive polymers and carbon nanotubes. | 7 | Physical Chemistry |
It is known through early Spanish accounts that native Ecuadorians used balsa rafts fitted with sails to travel along the northern Andean coast to trade. Indeed, the first king of Lambayeque, where axe-monies are known to have been manufactured, is said in ethnohistorical accounts to have arrived in the city by raft. The Chincha of Peru and Manteño of Ecuador in particular are good candidates for the origin many of these traders. Furthermore, there is solid archaeological evidence for the trade of Spondylus shells, which can be gathered between the Gulf of Guayaquil in Ecuador and the Gulf of Mexico, in the Andean highlands during the Chavín culture. Furthermore, contemporary accounts from the Balsas River in western Mexico report that the fathers and grandfathers of local men had traded with canoe-borne traders, who sometimes spent as long as half a year in the area. However, there is as yet no firm archaeological evidence of the presence of either Ecuadorians in Mexico or vice versa.
This trading system was therefore ancient; it is suggested by Dewan and Hosler that these traders operated along the Andean coast from Colombia in the north to Chile in the south as early as 100 BCE. Using mathematical models, they demonstrate that it is hypothetically possible for balsa rafts to sail not just along coastal routes, but in the open ocean between Ecuador and Michoacán. An earlier proposal for the route by Coe suggest a more coastal route for trade.
Hosler suggests that traders from South America introduced metallurgical techniques into western Mexico in two waves. First between and 1250 CE, and second between c. 1250 and the Spanish conquest. It was during the second period that axe-monies are found in western Mexico, though antecedent forms are found in contexts dated as early as 800 CE in Ecuador. Yet while both South American traditions were influential in western Mexico, idiomatic traits and styles arose in the region, growing out of the imported traditions. | 8 | Metallurgy |
Protein–lipid interaction is the influence of membrane proteins on the lipid physical state or vice versa.
The questions which are relevant to understanding of the structure and function of the membrane are: 1) Do intrinsic membrane proteins bind tightly to lipids (see annular lipid shell), and what is the nature of the layer of lipids adjacent to the protein? 2) Do membrane proteins have long-range effects on the order or dynamics of membrane lipids? 3) How do the lipids influence the structure and/or function of membrane proteins? 4) How do peripheral membrane proteins which bind to the layer surface interact with lipids and influence their behavior? | 1 | Biochemistry |
In Marfan syndrome, a connective tissue disorder, mutations in the gene encoding for the fibrillin-1 protein impact nearly every one of its domains. Such defects in fibrillin-1 affect the signaling of TGFβ, as microfibrils directly govern the activity of TGFβ. This hinders the formation of the extracellular matrix, and ultimately results in a severe phenotype which involves a few organ systems, including the central nervous system, circulatory system, ocular system, and skeletal system. | 1 | Biochemistry |
The synthesis and characterization of the platinum carbonyl dianions [Pt(CO)] (n = 1–10), also known as Chini clusters or more correctly Chini-Longoni clusters, are recognized by the scientific community as the most spectacular result of Chini's work.
Chini clusters follow the general formula of [Pt(CO)], 1 subunits. Although these clusters were first reported in 1969 by Chatt and Booth, their structure were not established until Chini and Longoni's work in 1976.
Chini clusters are based on a planar triangular building block that can be condensed as multiple units forming chains usually anywhere from two to ten units long. The chains are formed by stacking of the planar units, extending through platinum to platinum bonds forming trigonal prismatic clusters. Within a triangular unit, the platinum–platinum bond lengths are 2.65 Å and between units the Pt–Pt bond lengths are 3.05 Å. Cluster structure is easily disrupted by deposition onto surfaces such as carbon or silicon, where the chains are broken, but the triangular subunits remain intact. The tetramer [Pt(CO)] is the most common member of this series of clusters. These clusters undergo reversible redox. They catalyze the hydrogenation of alkenes, ketones, and aldehydes.
Chini clusters can also be converted heterometal clusters and catalyze pH driven redox reactions and transport. First, the Chini clusters are the source of platinum atoms for the mixed metal cluster synthesis. For instance, the reaction [Pt(CO)] with [Ag(PPh)] produces heterometal cluster [PtAg(CO)(PPh)]. Second, the Chini clusters with redox properties act as a catalyst that helps transport sodium ions and electrons in the same direction across a liquid membrane, driven by pH-gradient. The [Pt(CO)] platinum clusters, where n=4 – 6, are reduced by OH:
:(n-1)[Pt(CO)] + 2OH ↔ n[Pt(CO)] + HO + 1/2O | 7 | Physical Chemistry |
The lower gastrointestinal tract (GI), includes the small intestine and all of the large intestine. The intestine is also called the bowel or the gut. The lower GI starts at the pyloric sphincter of the stomach and finishes at the anus. The small intestine is subdivided into the duodenum, the jejunum and the ileum. The cecum marks the division between the small and large intestine. The large intestine includes the rectum and anal canal. | 1 | Biochemistry |
In genetics, coverage is one of several measures of the depth or completeness of DNA sequencing, and is more specifically expressed in any of the following terms:
*Sequence coverage (or depth) is the number of unique reads that include a given nucleotide in the reconstructed sequence. Deep sequencing refers to the general concept of aiming for high number of unique reads of each region of a sequence.
*Physical coverage, the cumulative length of reads or read pairs expressed as a multiple of genome size.
*Genomic coverage, the percentage of all base pairs or loci of the genome covered by sequencing. | 1 | Biochemistry |
In addition to the active metal (usually Fe or Co), two other components comprise the catalyst: promoters and the catalyst support. Promoters are additives that enhance the behavior of the catalyst. For F-T catalysts, typical promoters including potassium and copper, which are usually added as salts. The choice of promoters depends on the primary metal, iron vs cobalt. Iron catalysts need alkali promotion to attain high activity and stability (e.g. 0.5 wt% ). Potassium-doped α-FeO are synthesized under variable calcination temperatures (400–800 °C). Addition of Cu for reduction promotion, addition of , for structural promotion and maybe some manganese can be applied for selectivity control (e.g. high olefinicity). The choice of promoters depends on the primary metal, i.e., iron vs cobalt. While group 1 alkali metals (e.g., potassium), help iron catalysts, they poison cobalt catalysts.
Catalysts are supported on high-surface-area binders/supports such as silica, alumina, or zeolites. | 0 | Organic Chemistry |
The third stage of DNA demethylation is removal of the intermediate products of demethylation generated by a TET enzyme by base excision repair. As indicated above in Stage 2, after 5mC is first oxidized by a TET to form 5hmC, further oxidation of 5hmC by TET yields 5fC and oxidation of 5fC by TET yields 5caC. Both 5fC and 5caC are recognized by a DNA glycosylase, TDG, a base excision repair enzyme, as an abnormal base. As shown in the Figure in this section, TDG removes the abnormal base (e.g. 5fC) while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. In this Figure, the 8-OHdG is left in the DNA, since it may have been present when OGG1 attracted TET1 to the CpG site with a methylated cytosine. After an AP site is formed, AP endonuclease creates a nick in the phosphodiester backbone of the AP site that was formed when the TDG DNA glycosylase removed the 5fC or 5caC. The human AP endonuclease incises DNA 5′ to the AP site by a hydrolytic mechanism, leaving a 3′-hydroxyl and a 5′-deoxyribose phosphate (5' dRP) residue. This is followed by either short patch or long patch repair. In short patch repair, 5′ dRP lyase trims the 5′ dRP end to form a phosphorylated 5′ end. This is followed by DNA polymerase β (pol β) adding a single cytosine to pair with the pre-existing guanine in the complementary strand and then DNA ligase to seal the cut strand. In long patch repair, DNA synthesis is thought to be mediated by polymerase δ and polymerase ε performing displacement synthesis to form a flap. Pol β can also perform long-patch displacement synthesis. Long-patch synthesis typically inserts 2–10 new nucleotides. Then flap endonuclease removes the flap, and this is followed by DNA ligase to seal the strand. At this point there has been a complete replacement of the 5-methylcytosine by cytosine (demethylation) in the DNA sequence. | 1 | Biochemistry |
In 1963 J. O'M. Bockris, M. A. V. Devanathan and Klaus Müller proposed the BDM model of the double-layer that included the action of the solvent in the interface. They suggested that the attached molecules of the solvent, such as water, would have a fixed alignment to the electrode surface. This first layer of solvent molecules displays a strong orientation to the electric field depending on the charge. This orientation has great influence on the permittivity of the solvent that varies with field strength. The IHP passes through the centers of these molecules. Specifically adsorbed, partially solvated ions appear in this layer. The solvated ions of the electrolyte are outside the IHP. Through the centers of these ions pass the OHP. The diffuse layer is the region beyond the OHP. | 7 | Physical Chemistry |
For macroscopic bodies with known volumes and numbers of atoms or molecules per unit volume, the total van der Waals force is often computed based on the "microscopic theory" as the sum over all interacting pairs. It is necessary to integrate over the total volume of the object, which makes the calculation dependent on the objects shapes. For example, the van der Waals interaction energy between spherical bodies of radii R and R and with smooth surfaces was approximated in 1937 by Hamaker (using Londons famous 1937 equation for the dispersion interaction energy between atoms/molecules as the starting point) by:
where A is the Hamaker coefficient, which is a constant (~10 − 10 J) that depends on the material properties (it can be positive or negative in sign depending on the intervening medium), and z is the center-to-center distance; i.e., the sum of R, R, and r (the distance between the surfaces): .
The van der Waals force between two spheres of constant radii (R and R are treated as parameters) is then a function of separation since the force on an object is the negative of the derivative of the potential energy function,. This yields:
In the limit of close-approach, the spheres are sufficiently large compared to the distance between them; i.e., or , so that equation (1) for the potential energy function simplifies to:
with the force:
The van der Waals forces between objects with other geometries using the Hamaker model have been published in the literature.
From the expression above, it is seen that the van der Waals force decreases with decreasing size of bodies (R). Nevertheless, the strength of inertial forces, such as gravity and drag/lift, decrease to a greater extent. Consequently, the van der Waals forces become dominant for collections of very small particles such as very fine-grained dry powders (where there are no capillary forces present) even though the force of attraction is smaller in magnitude than it is for larger particles of the same substance. Such powders are said to be cohesive, meaning they are not as easily fluidized or pneumatically conveyed as their more coarse-grained counterparts. Generally, free-flow occurs with particles greater than about 250 μm.
The van der Waals force of adhesion is also dependent on the surface topography. If there are surface asperities, or protuberances, that result in a greater total area of contact between two particles or between a particle and a wall, this increases the van der Waals force of attraction as well as the tendency for mechanical interlocking.
The microscopic theory assumes pairwise additivity. It neglects many-body interactions and retardation. A more rigorous approach accounting for these effects, called the "macroscopic theory", was developed by Lifshitz in 1956. Langbein derived a much more cumbersome "exact" expression in 1970 for spherical bodies within the framework of the Lifshitz theory while a simpler macroscopic model approximation had been made by Derjaguin as early as 1934. Expressions for the van der Waals forces for many different geometries using the Lifshitz theory have likewise been published. | 6 | Supramolecular Chemistry |
As a liquid is supercooled, the difference in entropy between the liquid and solid phase decreases. By extrapolating the heat capacity of the supercooled liquid below its glass transition temperature, it is possible to calculate the temperature at which the difference in entropies becomes zero. This temperature has been named the Kauzmann temperature.
If a liquid could be supercooled below its Kauzmann temperature, and it did indeed display a lower entropy than the crystal phase, the consequences would be paradoxical. This Kauzmann paradox has been the subject of much debate and many publications since it was first put forward by Walter Kauzmann in 1948.
One resolution of the Kauzmann paradox is to say that there must be a phase transition before the entropy of the liquid decreases. In this scenario, the transition temperature is known as the calorimetric ideal glass transition temperature T. In this view, the glass transition is not merely a kinetic effect, i.e. merely the result of fast cooling of a melt, but there is an underlying thermodynamic basis for glass formation. The glass transition temperature: | 7 | Physical Chemistry |
In addition to the academic research, several companies have been set up to commercialize 3D optical data storage and some large corporations have also shown an interest in the technology. However, it is not yet clear whether the technology will succeed in the market in the presence of competition from other quarters such as hard drives, flash storage, and holographic storage.
*Call/Recall was founded in 1987 on the basis of Peter Rentzepis' research. Using two–photon recording (at 25 Mbit/s with 6.5 ps, 7 nJ, 532 nm pulses), one–photon readout (with 635 nm), and a high NA (1.0) immersion lens, they have stored 1 TB as 200 layers in a 1.2 mm thick disk. They aim to improve capacity to >5 TB and data rates to up to 250 Mbit/s within a year, by developing new materials as well as high-powered pulsed blue laser diodes.
*Mempile are developing a commercial system with the name TeraDisc. In March 2007, they demonstrated the recording and readback of 100 layers of information on a 0.6 mm thick disc, as well as low crosstalk, high sensitivity, and thermodynamic stability. They intend to release a red-laser 0.6-1.0 TB consumer product in 2010, and have a roadmap to a 5 TB blue-laser product.
*Constellation 3D developed the Fluorescent Multilayer Disc at the end of the 1990s, which was a ROM disk, manufactured layer by layer. The company failed in 2002, but the intellectual property (IP) was acquired by D-Data Inc., who are attempting to introduce it as the Digital Multilayer Disk (DMD).
*Storex Technologies has been set up to develop 3D media based on fluorescent photosensitive glasses and glass-ceramic materials. The technology derives from the patents of the Romanian scientist Eugen Pavel, who is also the founder and CEO of the company. At ODS2010 conference were presented results regarding readout by two non-fluorescence methods of a Petabyte Optical Disc.
*Landauer Inc. are developing a media based on resonant two-photon absorption in a sapphire single crystal substrate. In May 2007, they showed the recording of 20 layers of data using 2 nJ of laser energy (405 nm) for each mark. The reading rate is limited to 10 Mbit/s because of the fluorescence lifetime.
*Colossal Storage aim to develop a 3D holographic optical storage technology based on photon-induced electric field poling using a far UV laser to obtain large improvements over current data capacity and transfer rates, but as yet they have not presented any experimental research or feasibility study.
*Microholas operates out of the University of Berlin, under the leadership of Prof Susanna Orlic, and has achieved the recording of up to 75 layers of microholographic data, separated by 4.5 micrometres, and suggesting a data density of 10 GB per layer.
*3DCD Technology Pty. Ltd. is a university spin-off set up to develop 3D optical storage technology based on materials identified by Daniel Day and Min Gu.
*Several large technology companies such as Fuji, Ricoh, and Matsushita have applied for patents on two–photon-responsive materials for applications including 3D optical data storage, however they have not given any indication that they are developing full data storage solutions. | 5 | Photochemistry |
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