oracat commited on
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d954b92
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1 Parent(s): 670de19

Update app.py

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  1. app.py +4 -4
app.py CHANGED
@@ -73,10 +73,10 @@ def demo_immunology_callback():
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  def demo_virology_callback():
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  """
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- Use https://doi.org/10.1016/j.cell.2020.08.001 for demo
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  """
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- paper_title = "Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment"
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- paper_abstract = "Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19."
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  st.session_state["title"] = paper_title
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  st.session_state["abstract"] = paper_abstract
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@@ -130,7 +130,7 @@ if len(text.strip()) > 0:
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  else:
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  out_text = f"This paper is likely to be from the category **{results[0]['label']}** *(score {results[0]['score']:.2f})*."
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  if len(results) > 1:
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- out_text += "\n\n(Other fitting categories are " + " and ".join(
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  [
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  f"{item['label']} *(score {item['score']:.2f})*"
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  for item in results[1:]
 
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  def demo_virology_callback():
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  """
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+ Use https://doi.org/10.4269/ajtmh.20-0849 for demo
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  """
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+ paper_title = "The Origin of COVID-19 and Why It Matters"
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+ paper_abstract = "The COVID-19 pandemic is among the deadliest infectious diseases to have emerged in recent history. As with all past pandemics, the specific mechanism of its emergence in humans remains unknown. Nevertheless, a large body of virologic, epidemiologic, veterinary, and ecologic data establishes that the new virus, SARS-CoV-2, evolved directly or indirectly from a β-coronavirus in the sarbecovirus (SARS-like virus) group that naturally infect bats and pangolins in Asia and Southeast Asia. Scientists have warned for decades that such sarbecoviruses are poised to emerge again and again, identified risk factors, and argued for enhanced pandemic prevention and control efforts. Unfortunately, few such preventive actions were taken resulting in the latest coronavirus emergence detected in late 2019 which quickly spread pandemically. The risk of similar coronavirus outbreaks in the future remains high. In addition to controlling the COVID-19 pandemic, we must undertake vigorous scientific, public health, and societal actions, including significantly increased funding for basic and applied research addressing disease emergence, to prevent this tragic history from repeating itself."
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  st.session_state["title"] = paper_title
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  st.session_state["abstract"] = paper_abstract
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  else:
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  out_text = f"This paper is likely to be from the category **{results[0]['label']}** *(score {results[0]['score']:.2f})*."
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  if len(results) > 1:
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+ out_text += "\n(Other fitting categories are " + " and ".join(
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  [
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  f"{item['label']} *(score {item['score']:.2f})*"
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  for item in results[1:]