REIGN OVER ME (2007) *** Adam Sandler, Don Cheadle, Jada Pinkett-Smith, Liv Tyler, Saffron Burrows, Donald Sutherland, Robert Klein, Melinda Dillon, Mike Binder, Jonathan Banks, Rae Allen, Paula Newsome. At times affecting and at times middling dramedy about a thoroughly depressed man who lost his family on 9/11 (Sandler in his best role since "Punch-Drunk Love") who winds up re-united with his old college roommate and friend (Cheadle continuing to do impressive work with every role to date), a well-to-do dentist who seems to have it all  family, wealth, happiness  but really sees an ally in freedom with his troubled friend's own personal life offerings. Written and directed by Binder (who co-stars as Sandler's former-best friend and acting accountant) with equal parts humor and genuine heartache the film works best when the two stars share the screen until the last act falls into an almost movie-of-the-week treacle with to tidy a solution to the matters at hand.