The network began running into some trouble in the ratings by 2010. That year, the sixth and final season of Lost became the drama's lowest-rated season since its debut in 2004. Ratings for the once-instant hit Ugly Betty collapsed dramatically after it was moved to Fridays at the start of its fourth season in the fall of 2009; an attempt to boost ratings by moving the dramedy to Wednesdays failed, with its ultimate cancellation by the network eliciting negative reaction from the public, and particularly the show's fanbase. With the network's two former hit shows now out of the picture, the network's remaining top veteran shows Desperate Housewives and Grey's Anatomy, and another hit drama Brothers & Sisters, all ended the 2009–10 season recorded their lowest ratings ever.