A term used originally in derision, Huguenot has unclear origins. Various hypotheses have been promoted. The nickname may have been a combined reference to the Swiss politician Besançon Hugues (died 1532) and the religiously conflicted nature of Swiss republicanism in his time, using a clever derogatory pun on the name Hugues by way of the Dutch word Huisgenoten (literally housemates), referring to the connotations of a somewhat related word in German Eidgenosse (Confederates as in "a citizen of one of the states of the Swiss Confederacy"). Geneva was John Calvin's adopted home and the centre of the Calvinist movement. In Geneva, Hugues, though Catholic, was a leader of the "Confederate Party", so called because it favoured independence from the Duke of Savoy through an alliance between the city-state of Geneva and the Swiss Confederation. The label Huguenot was purportedly first applied in France to those conspirators (all of them aristocratic members of the Reformed Church) involved in the Amboise plot of 1560: a foiled attempt to wrest power in France from the influential House of Guise. The move would have had the side effect of fostering relations with the Swiss. Thus, Hugues plus Eidgenosse by way of Huisgenoten supposedly became Huguenot, a nickname associating the Protestant cause with politics unpopular in France.[citation needed]