Around 2.5 million years ago (ending 11,600 years ago) was the geological period of the Ice Ages. Since approximately 600,000 years ago, six major Ice Ages have occurred, in which sea level dropped 120 m (390 ft) and much of the continental margins became exposed. In the Early Pleistocene, the Rhine followed a course to the northwest, through the present North Sea. During the so-called Anglian glaciation (~450,000 yr BP, marine oxygen isotope stage 12), the northern part of the present North Sea was blocked by the ice and a large lake developed, that overflowed through the English Channel. This caused the Rhine's course to be diverted through the English Channel. Since then, during glacial times, the river mouth was located offshore of Brest, France and rivers, like the Thames and the Seine, became tributaries to the Rhine. During interglacials, when sea level rose to approximately the present level, the Rhine built deltas, in what is now the Netherlands.