Perhaps the most prominent, controversial and far-reaching theory in all of science has been the theory of evolution by natural selection put forward by the British naturalist Charles Darwin in his book On the Origin of Species in 1859. Darwin proposed that the features of all living things, including humans, were shaped by natural processes over long periods of time. The theory of evolution in its current form affects almost all areas of biology. Implications of evolution on fields outside of pure science have led to both opposition and support from different parts of society, and profoundly influenced the popular understanding of "man's place in the universe". In the early 20th century, the study of heredity became a major investigation after the rediscovery in 1900 of the laws of inheritance developed by the Moravian monk Gregor Mendel in 1866. Mendel's laws provided the beginnings of the study of genetics, which became a major field of research for both scientific and industrial research. By 1953, James D. Watson, Francis Crick and Maurice Wilkins clarified the basic structure of DNA, the genetic material for expressing life in all its forms. In the late 20th century, the possibilities of genetic engineering became practical for the first time, and a massive international effort began in 1990 to map out an entire human genome (the Human Genome Project).