Paris is located in northern central France. By road it is 450 kilometres (280 mi) south-east of London, 287 kilometres (178 mi) south of Calais, 305 kilometres (190 mi) south-west of Brussels, 774 kilometres (481 mi) north of Marseille, 385 kilometres (239 mi) north-east of Nantes, and 135 kilometres (84 mi) south-east of Rouen. Paris is located in the north-bending arc of the river Seine and includes two islands, the Île Saint-Louis and the larger Île de la Cité, which form the oldest part of the city. The river's mouth on the English Channel (La Manche) is about 233 mi (375 km) downstream of the city, established around 7600 BC. The city is spread widely on both banks of the river. Overall, the city is relatively flat, and the lowest point is 35 m (115 ft) above sea level. Paris has several prominent hills, the highest of which is Montmartre at 130 m (427 ft). Montmartre gained its name from the martyrdom of Saint Denis, first bishop of Paris, atop the Mons Martyrum, "Martyr's mound", in 250.