Among the largest non-state-run research institutions in Portugal are the Instituto Gulbenkian de Ciência and the Champalimaud Foundation, a neuroscience and oncology research centre, which in addition awards every year one of the highest monetary prizes of any science prize in the world. A number of both national and multinational high-tech and industrial companies, are also responsible for research and development projects. One of the oldest learned societies of Portugal is the Sciences Academy of Lisbon, founded in 1779.