In 1847, Hungarian physician Ignác Fülöp Semmelweis dramatically reduced the occurrency of puerperal fever by simply requiring physicians to wash their hands before attending to women in childbirth. This discovery predated the germ theory of disease. However, Semmelweis' findings were not appreciated by his contemporaries and came into use only with discoveries by British surgeon Joseph Lister, who in 1865 proved the principles of antisepsis. Lister's work was based on the important findings by French biologist Louis Pasteur. Pasteur was able to link microorganisms with disease, revolutionizing medicine. He also devised one of the most important methods in preventive medicine, when in 1880 he produced a vaccine against rabies. Pasteur invented the process of pasteurization, to help prevent the spread of disease through milk and other foods.