The synthesis of urea by Friedrich Wöhler opened a new research field, organic chemistry, and by the end of the 19th century, scientists were able to synthesize hundreds of organic compounds. The later part of the 19th century saw the exploitation of the Earth's petrochemicals, after the exhaustion of the oil supply from whaling. By the 20th century, systematic production of refined materials provided a ready supply of products which provided not only energy, but also synthetic materials for clothing, medicine, and everyday disposable resources. Application of the techniques of organic chemistry to living organisms resulted in physiological chemistry, the precursor to biochemistry. The 20th century also saw the integration of physics and chemistry, with chemical properties explained as the result of the electronic structure of the atom. Linus Pauling's book on The Nature of the Chemical Bond used the principles of quantum mechanics to deduce bond angles in ever-more complicated molecules. Pauling's work culminated in the physical modelling of DNA, the secret of life (in the words of Francis Crick, 1953). In the same year, the Miller–Urey experiment demonstrated in a simulation of primordial processes, that basic constituents of proteins, simple amino acids, could themselves be built up from simpler molecules.