Combined with this influx of classical ideas was the invention of printing which facilitated dissemination of the printed word and democratized learning. These two things would later lead to the Protestant Reformation. Toward the end of the period, an era of discovery began (Age of Discovery). The rise of the Ottoman Empire, culminating in the Fall of Constantinople in 1453, eroded the last remnants of the Byzantine Empire and cut off trading possibilities with the east. Europeans were forced to seek new trading routes, leading to the expedition of Columbus to the Americas in 1492, and Vasco da Gama’s circumnavigation of India and Africa in 1498. Their discoveries strengthened the economy and power of European nations.