Iran is home to one of the world's oldest civilizations, beginning with the formation of the Proto-Elamite and Elamite kingdoms in 3200–2800 BC. The Iranian Medes unified the area into the first of many empires in 625 BC, after which it became the dominant cultural and political power in the region. Iran reached the pinnacle of its power during the Achaemenid Empire founded by Cyrus the Great in 550 BC, which at its greatest extent comprised major portions of the ancient world, stretching from parts of the Balkans (Thrace-Macedonia, Bulgaria-Paeonia) and Eastern Europe proper in the west, to the Indus Valley in the east, making it the largest empire the world had yet seen. The empire collapsed in 330 BC following the conquests of Alexander the Great. The Parthian Empire emerged from the ashes and was succeeded by the Sassanid Dynasty in 224 AD, under which Iran again became one of the leading powers in the world, along with the Roman-Byzantine Empire, for a period of more than four centuries.