import sys
import os
import pandas as pd
import json
import gradio as gr
from typing import List, Tuple, Dict, Any, Union
import hashlib
import shutil
import re
from datetime import datetime
import time
from concurrent.futures import ThreadPoolExecutor, as_completed

# Configuration and setup
persistent_dir = "/data/hf_cache"
os.makedirs(persistent_dir, exist_ok=True)

model_cache_dir = os.path.join(persistent_dir, "txagent_models")
tool_cache_dir = os.path.join(persistent_dir, "tool_cache")
file_cache_dir = os.path.join(persistent_dir, "cache")
report_dir = os.path.join(persistent_dir, "reports")

for directory in [model_cache_dir, tool_cache_dir, file_cache_dir, report_dir]:
    os.makedirs(directory, exist_ok=True)

os.environ["HF_HOME"] = model_cache_dir
os.environ["TRANSFORMERS_CACHE"] = model_cache_dir

current_dir = os.path.dirname(os.path.abspath(__file__))
src_path = os.path.abspath(os.path.join(current_dir, "src"))
sys.path.insert(0, src_path)

from txagent.txagent import TxAgent

MAX_MODEL_TOKENS = 32768
MAX_CHUNK_TOKENS = 8192
MAX_NEW_TOKENS = 2048
PROMPT_OVERHEAD = 500

def clean_response(text: str) -> str:
    try:
        text = text.encode('utf-8', 'surrogatepass').decode('utf-8')
    except UnicodeError:
        text = text.encode('utf-8', 'replace').decode('utf-8')
    text = re.sub(r"\[.*?\]|\bNone\b", "", text, flags=re.DOTALL)
    text = re.sub(r"\n{3,}", "\n\n", text)
    text = re.sub(r"[^\n#\-\*\w\s\.,:\(\)]+", "", text)
    return text.strip()

def estimate_tokens(text: str) -> int:
    return len(text) // 3.5 + 1

def extract_text_from_excel(file_path: str) -> str:
    all_text = []
    try:
        xls = pd.ExcelFile(file_path)
        for sheet_name in xls.sheet_names:
            df = xls.parse(sheet_name)
            df = df.astype(str).fillna("")
            rows = df.apply(lambda row: " | ".join(row), axis=1)
            sheet_text = [f"[{sheet_name}] {line}" for line in rows]
            all_text.extend(sheet_text)
    except Exception as e:
        raise ValueError(f"Failed to extract text from Excel file: {str(e)}")
    return "\n".join(all_text)

def split_text_into_chunks(text: str, max_tokens: int = MAX_CHUNK_TOKENS) -> List[str]:
    effective_max_tokens = max_tokens - PROMPT_OVERHEAD
    if effective_max_tokens <= 0:
        raise ValueError("Effective max tokens must be positive.")
    lines = text.split("\n")
    chunks, current_chunk, current_tokens = [], [], 0
    for line in lines:
        line_tokens = estimate_tokens(line)
        if current_tokens + line_tokens > effective_max_tokens:
            if current_chunk:
                chunks.append("\n".join(current_chunk))
            current_chunk, current_tokens = [line], line_tokens
        else:
            current_chunk.append(line)
            current_tokens += line_tokens
    if current_chunk:
        chunks.append("\n".join(current_chunk))
    return chunks

def build_prompt_from_text(chunk: str) -> str:
    return f"""
### Unstructured Clinical Records

Analyze the following clinical notes and provide a detailed, concise summary focusing on:
- Diagnostic Patterns
- Medication Issues
- Missed Opportunities
- Inconsistencies
- Follow-up Recommendations

---

{chunk}

---
Respond in well-structured bullet points with medical reasoning.
"""

def init_agent():
    default_tool_path = os.path.abspath("data/new_tool.json")
    target_tool_path = os.path.join(tool_cache_dir, "new_tool.json")
    if not os.path.exists(target_tool_path):
        shutil.copy(default_tool_path, target_tool_path)
    agent = TxAgent(
        model_name="mims-harvard/TxAgent-T1-Llama-3.1-8B",
        rag_model_name="mims-harvard/ToolRAG-T1-GTE-Qwen2-1.5B",
        tool_files_dict={"new_tool": target_tool_path},
        force_finish=True,
        enable_checker=True,
        step_rag_num=4,
        seed=100,
        additional_default_tools=[]
    )
    agent.init_model()
    return agent

def process_final_report(agent, file, chatbot_state: List[Dict[str, str]]) -> Tuple[List[Dict[str, str]], Union[str, None]]:
    messages = chatbot_state if chatbot_state else []
    report_path = None

    if file is None or not hasattr(file, "name"):
        messages.append({"role": "assistant", "content": "❌ Please upload a valid Excel file before analyzing."})
        return messages, report_path

    try:
        messages.append({"role": "user", "content": f"Processing Excel file: {os.path.basename(file.name)}"})
        extracted_text = extract_text_from_excel(file.name)
        chunks = split_text_into_chunks(extracted_text)
        chunk_responses = [None] * len(chunks)

        def analyze_chunk(index: int, chunk: str) -> Tuple[int, str]:
            prompt = build_prompt_from_text(chunk)
            prompt_tokens = estimate_tokens(prompt)
            if prompt_tokens > MAX_MODEL_TOKENS:
                return index, f"❌ Chunk {index+1} prompt too long. Skipping..."
            response = ""
            try:
                for result in agent.run_gradio_chat(
                    message=prompt,
                    history=[],
                    temperature=0.2,
                    max_new_tokens=MAX_NEW_TOKENS,
                    max_token=MAX_MODEL_TOKENS,
                    call_agent=False,
                    conversation=[],
                ):
                    if isinstance(result, str):
                        response += result
                    elif isinstance(result, list):
                        for r in result:
                            if hasattr(r, "content"):
                                response += r.content
                    elif hasattr(result, "content"):
                        response += result.content
            except Exception as e:
                return index, f"❌ Error analyzing chunk {index+1}: {str(e)}"
            return index, clean_response(response)

        with ThreadPoolExecutor(max_workers=1) as executor:
            futures = [executor.submit(analyze_chunk, i, chunk) for i, chunk in enumerate(chunks)]
            for future in as_completed(futures):
                i, result = future.result()
                chunk_responses[i] = result
                if result.startswith("❌"):
                    messages.append({"role": "assistant", "content": result})

        valid_responses = [res for res in chunk_responses if not res.startswith("❌")]
        if not valid_responses:
            messages.append({"role": "assistant", "content": "❌ No valid chunk responses to summarize."})
            return messages, report_path

        summary = "\n\n".join(valid_responses)
        final_prompt = f"Provide a structured, consolidated clinical analysis from these results:\n\n{summary}"
        messages.append({"role": "assistant", "content": "📊 Generating final report..."})

        final_report_text = ""
        for result in agent.run_gradio_chat(
            message=final_prompt,
            history=[],
            temperature=0.2,
            max_new_tokens=MAX_NEW_TOKENS,
            max_token=MAX_MODEL_TOKENS,
            call_agent=False,
            conversation=[],
        ):
            if isinstance(result, str):
                final_report_text += result
            elif isinstance(result, list):
                for r in result:
                    if hasattr(r, "content"):
                        final_report_text += r.content
            elif hasattr(result, "content"):
                final_report_text += result.content

        cleaned = clean_response(final_report_text)
        report_path = os.path.join(report_dir, f"report_{datetime.now().strftime('%Y%m%d_%H%M%S')}.md")
        with open(report_path, 'w') as f:
            f.write(f"# 🧠 Final Patient Report\n\n{cleaned}")

        messages.append({"role": "assistant", "content": f"📊 Final Report:\n\n{cleaned}"})
        messages.append({"role": "assistant", "content": f"✅ Report generated and saved: {os.path.basename(report_path)}"})

    except Exception as e:
        messages.append({"role": "assistant", "content": f"❌ Error processing file: {str(e)}"})

    return messages, report_path

def create_ui(agent):
    with gr.Blocks(css="""
        html, body, .gradio-container {
            height: 100vh;
            width: 100vw;
            margin: 0;
            padding: 0;
            font-family: 'Inter', sans-serif;
            background-color: #111827;
            color: #e5e7eb;
        }
        .gr-button.primary {
            background: #2563eb;
            color: white;
            border-radius: 6px;
            border: none;
            font-weight: 600;
        }
        .gr-button.primary:hover {
            background: #1e40af;
        }
        .gr-chatbot {
            background-color: #1f2937;
            color: #e5e7eb;
            border-radius: 10px;
            padding: 1rem;
            border: 1px solid #374151;
        }
        .gr-markdown, .gr-file-upload {
            background-color: #1f2937;
            border-radius: 10px;
            box-shadow: 0 0 10px rgba(0,0,0,0.2);
            border: 1px solid #374151;
        }
    """) as demo:
        gr.Markdown("""
        <h2 style='color:#60a5fa'>🩺 Patient History AI Assistant</h2>
        <p style='color:#cbd5e1'>Upload a clinical Excel file and receive a structured diagnostic summary.</p>
        """)

        with gr.Row():
            with gr.Column(scale=3):
                chatbot = gr.Chatbot(label="Clinical Assistant", height=700, type="messages")
            with gr.Column(scale=1):
                file_upload = gr.File(label="Upload Excel File", file_types=[".xlsx"])
                analyze_btn = gr.Button("🧠 Analyze", variant="primary")
                report_output = gr.File(label="Download Report", visible=False, interactive=False)

        chatbot_state = gr.State(value=[])

        def update_ui(file, current_state):
            messages, report_path = process_final_report(agent, file, current_state)
            return messages, gr.update(visible=report_path is not None, value=report_path), messages

        analyze_btn.click(fn=update_ui, inputs=[file_upload, chatbot_state], outputs=[chatbot, report_output, chatbot_state])

    return demo

if __name__ == "__main__":
    try:
        agent = init_agent()
        demo = create_ui(agent)
        demo.launch(server_name="0.0.0.0", server_port=7860, allowed_paths=["/data/hf_cache/reports"], share=False)
    except Exception as e:
        print(f"Error: {str(e)}")
        sys.exit(1)