import os
import sys
import gradio as gr
from multiprocessing import freeze_support
import importlib
import inspect
import json

# Fix path to include src
sys.path.insert(0, os.path.join(os.path.dirname(__file__), "src"))

# Reload TxAgent from txagent.py
import txagent.txagent
importlib.reload(txagent.txagent)
from txagent.txagent import TxAgent

# Debug info
print(">>> TxAgent loaded from:", inspect.getfile(TxAgent))
print(">>> TxAgent has run_gradio_chat:", hasattr(TxAgent, "run_gradio_chat"))

# Env vars
current_dir = os.path.abspath(os.path.dirname(__file__))
os.environ["MKL_THREADING_LAYER"] = "GNU"
os.environ["TOKENIZERS_PARALLELISM"] = "false"

# Model config
model_name = "mims-harvard/TxAgent-T1-Llama-3.1-8B"
rag_model_name = "mims-harvard/ToolRAG-T1-GTE-Qwen2-1.5B"
new_tool_files = {
    "new_tool": os.path.join(current_dir, "data", "new_tool.json")
}

# Sample questions
question_examples = [
    ["Given a patient with WHIM syndrome on prophylactic antibiotics, is it advisable to co-administer Xolremdi with fluconazole?"],
    ["What treatment options exist for HER2+ breast cancer resistant to trastuzumab?"]
]

# Format assistant responses in collapsible JSON-style panels
def format_collapsible(content):
    if isinstance(content, (dict, list)):
        try:
            formatted = json.dumps(content, indent=2)
        except Exception:
            formatted = str(content)
    else:
        formatted = str(content)

    return (
        "<details style='border: 1px solid #ccc; border-radius: 10px; padding: 12px; margin-top: 10px;'>"
        "<summary style='font-weight: 600; font-size: 16px;'>Answer</summary>"
        f"<pre style='white-space: pre-wrap; font-family: monospace; font-size: 14px;'>{formatted}</pre>"
        "</details>"
    )

# UI setup
def create_ui(agent):
    with gr.Blocks(css="""
        body { font-family: 'Segoe UI', sans-serif; background-color: #f8f9fa; }
        .gr-button-primary { background: linear-gradient(90deg, #4b6cb7, #182848); color: white; border: none; }
        .gr-button-primary:hover { background: linear-gradient(90deg, #5a78d1, #243b6c); }
        .gr-markdown h1 { margin-bottom: 0; }
        .gr-markdown { margin-bottom: 16px; }
    """) as demo:
        gr.Markdown("<h1 style='text-align: center;'>TxAgent: Therapeutic Reasoning</h1>")
        gr.Markdown("<p style='text-align: center;'>Ask biomedical or therapeutic questions. Powered by tool-augmented reasoning.</p>")

        with gr.Row():
            with gr.Column():
                temperature = gr.Slider(0, 1, value=0.3, label="Temperature")
                max_new_tokens = gr.Slider(128, 4096, value=1024, label="Max New Tokens")
                max_tokens = gr.Slider(128, 32000, value=8192, label="Max Total Tokens")
                max_round = gr.Slider(1, 50, value=30, label="Max Rounds")
                multi_agent = gr.Checkbox(label="Enable Multi-agent Reasoning", value=False)

        conversation_state = gr.State([])
        chatbot = gr.Chatbot(label="TxAgent", height=600, type="messages")
        message_input = gr.Textbox(placeholder="Ask your biomedical question...", show_label=False)
        send_button = gr.Button("Send", variant="primary")

        # Main handler
        def handle_chat(message, history, temperature, max_new_tokens, max_tokens, multi_agent, conversation, max_round):
            generator = agent.run_gradio_chat(
                message=message,
                history=history,
                temperature=temperature,
                max_new_tokens=max_new_tokens,
                max_token=max_tokens,
                call_agent=multi_agent,
                conversation=conversation,
                max_round=max_round
            )
            for update in generator:
                formatted = []
                for m in update:
                    role = m["role"] if isinstance(m, dict) else getattr(m, "role", "assistant")
                    content = m["content"] if isinstance(m, dict) else getattr(m, "content", "")
                    if role == "assistant":
                        content = format_collapsible(content)
                    formatted.append({"role": role, "content": content})
                yield formatted

        inputs = [message_input, chatbot, temperature, max_new_tokens, max_tokens, multi_agent, conversation_state, max_round]
        send_button.click(fn=handle_chat, inputs=inputs, outputs=chatbot)
        message_input.submit(fn=handle_chat, inputs=inputs, outputs=chatbot)

        gr.Examples(examples=question_examples, inputs=message_input)
        gr.Markdown("<p style='font-size: 12px; color: gray;'>DISCLAIMER: This demo is for research purposes only and does not provide medical advice.</p>")

    return demo

# Entry point
if __name__ == "__main__":
    freeze_support()
    try:
        agent = TxAgent(
            model_name=model_name,
            rag_model_name=rag_model_name,
            tool_files_dict=new_tool_files,
            force_finish=True,
            enable_checker=True,
            step_rag_num=10,
            seed=100,
            additional_default_tools=[]
        )
        agent.init_model()

        if not hasattr(agent, "run_gradio_chat"):
            raise AttributeError("TxAgent missing run_gradio_chat")

        demo = create_ui(agent)
        demo.queue().launch(
            server_name="0.0.0.0",
            server_port=7860,
            share=True,
            show_error=True
        )

    except Exception as e:
        print(f"\u274c App failed to start: {e}")
        raise