Title of Invention: Lisuride, Terguride and Derivatives Thereof for Use in the Prophylaxis and/or Treatment of Fibrotic Changes Abstract: The present invention relates to the use of 5-HT2 receptor antagonists and in particular of 8-α-ergolines such as lisuride, terguride and the derivatives thereof as 5-HT2B and 5-HT2A receptor antagonists and antioxidants in preferably higher-dosed and preferably continuous use for the treatment, progression prophylaxis and general prophylaxis of organ fibroses and other pathological organ remodeling caused by mesenchymal proliferation Detailed Description: Subjects of this invention are lisuride, terguride and derivatives of general formula (I) R1: Allyl, alkinyl R2: Ethyl, n-propyl, i-propyl, allyl R3: Hydrogen, methyl, ethyl, n-propyl, i-propyl, —CH2OH whereby the bond between C9/C10 is either a single bond or a double bond, for use in the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing these fibrotic changes in organs and their vascular structure. In addition, pharmaceutical formulations as well as special applications, as well as combinations with additional active ingredients and pharmaceutical formulations in combination with additional active ingredients are the subjects of this invention. BACKGROUND OF THE INVENTION There are a number of diseases in which pathological fibrotic and sclerotizing changes in organs and organ systems with or without collagen deposits and pathological changes in organ structure and function result by a proliferation of connective-tissue cells and other cells of mesenchymal origin. These include primarily fibrotic organ changes with or without increased collagen formation and deposits, as are found in systemic diseases or infections (for example by HIV, Aspergillus, mycobacteria, parasites). Primary fibrosis-inducing pathological changes are found in many organs (for example, liver fibrosis, glomerulosclerosis, scleroderma, pulmonary fibrosis of many different origins, other restrictive pulmonary diseases, retroperitoneal and pleural fibroses), in part also with increased collagen production and deposits as a result of 5-HT-(=serotonin)- induced trophic effects. Also included in this respect are all forms of elevated pulmonary vascular pressure, for example as a sequela of restrictive or obstructive pulmonary diseases (for example, chronic-obstructive pulmonary disease (COPD)) as well as the right ventricular hypertrophy as a result of elevated pulmonary pressure. 5-HT can trigger these changes directly (for example released from carcinoid tumors) or secondarily (for example as a result of thrombocyte aggregation of other causes in the affected tissue with local 5-HT concentration and release). As a sequela of the fibrosis-inducing process, the above-mentioned diseases also do not respond or respond to an only very limited extent to regional and/or systemic vasodilating medications, such as the known pulmonary vasodilators (prostacyclins, endothelin antagonists, phosphodiesterase-5 inhibitors) and systemic vasodilators. Primarily the above-mentioned pulmonary vasodilators fairly often even worsen the clinical picture [Ulrich-Somaini, S., 2009]. All of these products used to date for symptomatic treatment also have in some cases quite considerable side-effects. Within the framework of this invention, it has now been found, surprisingly enough, that the combination of high 5-HT2B- and 5-HT2A-receptor affinity with strong antioxidative action has the greatest therapeutic effects. The compounds according to the invention exert their maximum effectiveness in a continuous application and from the resulting medication level that is as constant as possible. Lisuride and terguride as well as the derivatives thereof are known for the use in the treatment of pulmonary arterial high pressure (PAH), glomerulosclerosis and secondary Raynaud's Syndrome. The effects that occur by the combination of high 5-HT2B- and 5-HT2A-receptor affinity presented here in connection with the antioxidative action in the same molecules were not known, however. This gives rise to quite new treatment fields and applications. Subjects of this invention are thus lisuride, terguride and derivatives of lisuride and terguride with the general formula (I) R1: Allyl, alkinyl R2: Ethyl, n-propyl, i-propyl, allyl R3: Hydrogen, methyl, ethyl, n-propyl, i-propyl, —CH2OH whereby the bond between C9/C10 is either a single bond or a double bond, for use in the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing these fibrotic changes in organs and their vascular structure. Encompassed as subjects of this invention are in particular both 8α-enantiomers and 8β-enantiomers of the compounds according to the invention according to general formula I. In particular, 8α-lisuride and 8α-terguride as well as 8β-lisuride and 8β-terguride are thus subjects of this invention. This is surprising, since the alpha-configuration is decisive for the known dopaminergic action of the substances. A change in the configuration in the 8-position for beta-configuration means a loss of the dopaminergic action. With respect to the action on 5-HT2B- and 5-HT2A receptors according to the invention, however, both configurations are effective, see Table 3, Example 11. This can considerably improve the compatibility of these treatments in fibrosis-inducing diseases. The terms “fibrotic changes in organs and their vascular structure” comprise fibrotic changes in organs and/or organ systems as well as pathological structural changes in organs and/or organ systems by mesenchymal proliferation; the term organ fibrosis is also commonly used. Surprisingly enough, the use of lisuride, terguride and derivatives of general formula (I) according to the invention in prophylaxis and/or treatment results in extending the life of the organism. The treatment with the compounds according to the invention results in general improvement by impeding or reversing the fibrotic changes and thus in an extension of the life expectancy. Organisms in terms of the invention are mammals, in particular human organisms, i.e., in particular humans who are suffering from fibrosis, for example. The use in the prophylaxis and/or treatment of the above-mentioned diseases of lisuride, terguride and derivatives of general formula (I) is carried out preferably such that during the treatment time, at least 80% of the time, preferably at least 100% of the treatment time, the 5-HT2B- and/or 5-HT2A-receptor occupancy in the target organ is in most cases preferably complete, but at least 90%, preferably at least 95%, most preferably 100%, i.e., complete. In terms of this invention, the target organ is any fibrotic, connective tissue growth or tissue in the organism that is pathologically changed by another mesenchymal growth. With “treatment time,” the following is meant: The receptor blocking must be carried out preferably almost completely and preferably as long as disease symptoms exist, over the entire time period, i.e., 7 days per week and 24 hours during the day. That is, 80% of the treatment time means, for example, 19.2 hours during the day. The receptor affinity as a measurement for the blocking of the receptors of lisuride is determined in validated in-vitro systems such as the isolated pulmonary artery of the young pig (see Example 11) in a functional assay, where defined actions of 5-HT on these receptors are inhibited. The determination of the receptor density, however, can be carried out semi-quantitatively or quantitatively, namely as follows: Pulmonary tissue is fixed in a 4% paraformaldehyde solution and then embedded in paraffin. 3-μm sections are heated under pressure for immunohistochemistry according to manufacturer's instructions (Zymed Labs./Invitrogen, Carlsbad, Calif., USA) in 6.5 mmol of Na-citrate (pH 6.0) and incubated with antibodies against 5-HT2B receptors (ab12926 of Abcam, Cambridge, UK) 1:200 and stained in sections with the Vulcan fast red Chromogen kit (Zymed) and compared to control tissue (see, for example, Dumitrascu et al., Eur. Resp. J. 37, 1104-1118, 2011). Quantitative Reverse-Transcriptase Polymerase Chain Reaction (q RT-PCR) is carried out with RNA isolated from frozen pulmonary tissue and cDNA induced by the latter (Promega, Madison, Wi., USA) in the Mx3000P Real-Time PCR System (Stratagene, La Jolla, Calif., USA), and the receptor RNA is then quantitatively determined against a porphobilinogen reference from the same tissue (see, for example, Dumitrascu et al., see above). The extraordinarily high 5-HT2B- and 5-HT2A-receptor affinity of lisuride and its derivatives and their largely uniform and quick uptake into the tissue results in a generally complete receptor blocking, as, i.a., studies with radiolabeled lisuride can show. In this case, the tissue that is to be studied before or after a lisuride treatment in the test model is prepared and homogenized, and then the specific lisuride bond is determined by a common measurement of the radioactivity in the scintillation counter. By the high receptor affinity, in this case a local concentration of these active ingredients in the pathologically changed tissue results; in particular there, the corresponding receptors are also often expressed to an increased extent. With the herewith connected locally reinforced antioxidation action, this then also results in a very specific action on the tissue pathology. The receptors themselves in this case were immunohistochemically visualized in the tissue or else quantified with, for example, RT-PCR, as described above. High 5-HT2B- and 5-HT2A-receptor affinity in terms of this invention means a pA2 value of 7 (i.e., above the corresponding value for the physiological agonists 5-HT, which is on the 5-HT2b sarahbrown@example.org), is better at 8 and preferably at 9 or higher (see Example 11). In this case, the pA2 value reflects the negatively decade logarithm of the concentration of an antagonist, which makes it necessary to double the agonist concentration in order to restore the initial effect of the agonist without antagonists. These studies are carried out either in cloned human receptors, which are expressed on CHO cells (Newman-Tancredi et al., J. Pharmacol. Exper. Ther. 303, 815-822, 2002), or, as described in Example 11, with a functional receptor assay on pulmonary or coronary arteries in pigs (Görnemann et al., J. Pharmacol. Exp. Ther. 324, 1136-1145, 2008). Another integral part of the invention in a preferred embodiment is that the active ingredient level of lisuride, terguide and derivatives of general formula (I) in systemic circulation of the organism during the treatment time is at least 5 pg/ml, most preferably 300-500 pg/ml, at least 80% of the time, and most preferably 100% of the treatment time continuously. This has shown a determination of the active ingredient level by specific bioassays (for example, LC/MS/MS or radioimmunoassays) in pharmacokinetic studies on test subjects. It follows from this that a good—but in any case treatment-sufficient—correlation between the infused amount of lisuride and the thus produced plasma concentrations exists and thus also with the receptor blocking. Also, a possible overdosage is not problematic, since lisuride and its derivatives are pure antagonists without any inherent agonistic (e.g., disease-carrying) action. In addition, there are sufficient clinical results, according to which even higher dosages, as are used for Parkinson's treatment, were well-tolerated. These considerations also hold true for other pharmaceutical forms for achieving adequately high constant plasma levels such as, for example, transdermal forms of application or high-dosed oral delayed-release formulations. In the above-mentioned pharmacokinetic studies on test subjects, unchanged lisuride was determined selectively and with high accuracy in blood plasma by an HPLC method with mass-spectrometric detection (LC/MS/MS). The analytical determinations were performed with tert-butyl-methyl ether extracts from plasma samples, whereby in each case, 400 μl of plasma was extracted with 900 μl of tbmE, which contained the external standard proterguride (2 ng/ml). After evaporation in the organic mobile solvent acetonitrile/water (30:70)/0.1% formic acid, the extract was taken up and chromatographed with a flow rate of 300 μl/min on a C6-phenyl column by means of gradient elution (10 mmol of ammonium formate/0.1% formic acid against the above-mentioned organic mobile solvent. The detection was done with use of a mass spectrometer (TSQ) with electrospray (ESI)-interface. Sensitivity and selectivity for lisuride (n=5) was determined with 9% standard deviation and a signal/noise ratio of 40 at a concentration of 20 pg/ml. The precision of the method was determined, for example, at a concentration of 60 pg/ml with 3% standard deviation, and the lower quantitative detection limit (LLoQ) was determined with 5 pg/ml. This means that the values and information given above on the active ingredient level in the systemic circulation of the organism during the treatment time can be determined according to such a method. Surprisingly enough, the very high affinity of the described substances for 5-HT2B receptors (antagonistic effectiveness at up to 10−10 M concentrations) also has an advantageous effect in that the active ingredients can accumulate primarily in the fibrotized organs, in which the 5-HT2 subreceptors are often especially strongly expressed. Since, for example, a molecule of lisuride can take up to 6 free oxygen radicals, the described substances in addition have an anti-fibrotic and anti-inflammatory action even via this mechanism. This happens especially where such an antioxidative action by enhanced receptor expression is urgently desired for therapeutic purposes. It is also advantageous that the described 5-HT2B antagonists antagonize only the elevated arterial blood pressure in the lungs, but do not influence the systemic blood pressure to a significant extent. Higher blood pressure results either from a disease and stenosis of the arteries and the arterioles and capillaries downstream therefrom; this is the case in arteriosclerotic systemic high pressure (as is determined with the commonly used manometric blood pressure measurement), but also in vascularly caused idiopathic high pressure in the lungs (here, the vascular pressure is determined by an inserted heart catheter or indirectly by echocardiography). The second possible cause for elevated arterial pressure lies in an elevated resistance in blood-supplied organs, as is caused by, for example, organ fibroses (or else in the case of kidneys by glomerulosclerosis). It is surprising that the substances according to the invention with 5-HT2B antagonism not only antagonize the fibrosis-causing effects of 5-HT but also can produce a restructuring, i.e., a renewed “remodeling” of pathological organ structures. They thus promote the additional remodeling of normal organ structure and function. This relates, for example in the case of elevated pulmonary pressure, not only to the pulmonary vessels, but rather also to the heart, in particular the right heart. In this case, it is significant that patients with pulmonary hypertension frequently die early because of the resulting hypertrophy of the right ventricle and right-heart failure resulting therefrom, so that the described therapeutic effect of the 5-HT2B antagonists can extend life. Surprisingly enough, such a remodeling effect of the described 5-HT2B antagonists on the hypertrophied heart is primarily not exclusively the result of an improvement of the excessive arterial pulmonary pressure and pulmonary fibrosis but rather also its function. In this case, this is an independent therapeutic effect of the 5-HT2B antagonists on the myocardial hypertrophy caused by excessive 5-HT2B stimulation, an effect that can be detected even a short time after the beginning of treatment (for example, by means of echocardiography). It is possible that this ontogenetically reflects a leading role of 5-HT2B receptors in the normal structure of the heart in the prenatal phase. In the example of the heart ventricle, new studies by Villeneuve et al. [2009] have shown that 5-HT, possibly released from thrombocytes, triggers the pathological remodeling of the heart, as precedes heart failure (and death), in a decisive way, but by different pathways. In this case, Villeneuve et al. distinguish the growth of the fibroblasts of the heart, where hypertrophy-promoting cytokines and interleukins are released via 5-HT2B-receptor activation, by a direct activation of cardial myoblasts. This activation by 5-HT is done via 5-HT2A receptors, at higher 5-HT concentrations but also by its uptake via a specific 5-HT-uptake mechanism directly into these cells, where 5-HT then likewise induces pathological growth and organ remodeling using the monoaminoxidase A by the formation of free radicals (“reactive oxygen species, ROS”). In the case of the substances according to the invention, it has been shown, surprisingly enough, that, for example, lisuride, but also terguride and derivatives thereof, in addition to their strong 5-HT2B antagonistic effectiveness in concentrations of similar orders of magnitude, also are strong peripheral 5-HT2A antagonists: they thus inhibit not only the secondary thrombocyte aggregation [Glusa, E. et al., 1984] independently of their triggering, but also the direct activation and proliferation of myoblasts themselves. In addition, these substances, surprisingly enough, are extremely strong radical traps. Thus, an individual molecule of lisuride can take up to 6 free oxygen radicals, terguride up to 4. Studies on 5-HT2-induced cardiac hypertrophy have demonstrated that this process runs with the generation of oxygen radicals [Bianchi, P. et al., 2005]. When it is further taken into consideration that these substances are preferably concentrated on the latter by their unprecedentedly high 5-HT2-receptor affinity (which in turn are locally strongly expressed in the case of organ hypertrophy), this combined property thus also significantly contributes to an inhibition of pathological organ growth. Moreover, these substances also have an inflammation-inhibiting effect on all of these mechanisms, so that they are effective even in the case of inflammation-triggered organ pathology (for example even in the case of pulmonary arterial high pressure triggered by COPD or infections). Such a combination of desired action mechanisms, as in the case of the described substances, could also not have been predicted by one skilled in the art in this field. Indeed, the substances according to the invention have the effects listed below against organ fibroses, organ hypertrophies, and pathological organ remodeling. In addition to the direct effects, this also includes indirect effects of 5-HT2B-receptor antagonists with resulting anti-fibrotic and anti-proliferative action, as listed below: Direct effects of the substances according to the invention: 1. Inhibition of 5-HT2B receptor activation, such as leads to the growth of fibroblasts and their mesenchymal pathological sequelae; 2. Inhibition of 5-HT2A-receptor activation, such as is carried out in secondary thrombocyte aggregation and 5-HT release resulting therefrom; 3. Inhibition of 5-HT2A receptors on organ-specific cells, such as are increasingly expressed, for example, on myoblasts and lead to pathological organ hypertrophy; 4. Inhibition of the production and action of free oxygen radicals (ROS), such as result in an independent mechanism for organ hypertrophy, as highly effective radical traps. Indirect effects of the substances according to the invention: 1. Inhibiting effects on remodeling processes, such as are produced from the interaction of 5-HT2B-receptor antagonists with the 5-HT transporter and with respect to the 5-HT clearance in the lungs. 2. Inhibition of the fibrotic organ remodeling by interaction of the substances according to the invention with pro-fibrotic mediators, such as, for example, PDGF and cytokines. Surprisingly enough, specifically in the described fibrotic diseases, the 8-α-ergolines lisuride and terguride as well as the derivatives thereof are effective, namely because of their direct antagonistic effects on trophic activation of fibroblasts, fibromyoblasts, T cells and other mesenchyme cells, such as are produced primarily by an activation of 5-HT2B receptors as well as by other non-vascular mechanisms. In this case, for the desired inhibition, fibrotic organ remodeling is primarily of importance in that in the compounds according to the invention, the described 5-HT2B antagonistic effect is also combined, surprisingly enough, with strong antioxidative action, which distinguishes these substances as excellent radical traps. The combination of high 5-HT2-receptor affinity with strong antioxidative action, such as exists in lisuride and its derivatives, is surprising and of great importance, if, as consequently has been determined in recent studies, for example, the pathogenetic process of 5-HT2-induced cardiac hypertrophy runs with generation of oxygen radicals [Bianchi, P. et al., 2005] and can be antagonized by radical traps [Redout, E. M. et al., 2010]. Serotonin, however, can also generate free radicals, independently of receptors, if it is released from thrombocytes at high local concentrations. In particular, the newly found combined effect, as described above, thus contributes significantly to inhibition of pathological tissue growth, since it simultaneously inhibits different pathogenetic mechanisms. In this connection, it is important that these new and surprising actions of lisuride and its derivatives can be achieved primarily by higher-dosed applications of active ingredients that are as continuous as possible. Such an application has already been proven to be well-tolerated, individually adjustable as required, and highly effective in continuous dopaminergic stimulation in the case of advanced Parkinson's disease [Stocchi, F. et al., 2002]. In the case of the above-mentioned, surprising new applications, the actions are not based on the known dopaminergic effects of lisuride, however, but rather on its high antagonistic action on 5-HT2B receptors [Jaehnichen, S. et al., 2005] in combination with its 5-HT2A antagonism and its strong antioxidative action [Bianchi, P. et al., 2005]. These fibrosis-inducing and proliferative pathological organ diseases are characterized in that they are produced primarily or secondarily by 5-HT (serotonin) and/or oxidative stress. They are produced primarily by the activation of trophic 5-HT receptors (generally subtypes of the 5-HT2 receptor), and often the local 5-HT concentrations (for example, from thrombocytes) are increased and/or the trophic receptors are expressed to an increased extent. In this case, it is also important that even short pulses of elevated 5-HT release (such as, for example, in the Carcinoid Syndrome) and/or short phases of oxidative stress can result in permanent pathological organ remodeling with damage to the organ function. In particular by the applications that have already proven to be of value in the case of lisuride in other indications (for example by sc infusions using portable mini-pumps, by transdermal therapeutic systems, but also other depot forms), it is possible to ensure an inhibition of the serotonin-induced trophic activation of fibroblasts, T cells and other mesenchymal cells completely and over the entire day and night and thus to prevent a possible “breakthrough or escape phenomenon” with ineffectiveness resulting therefrom. The same effect can also be reached with good compatibility by higher-dosed, oral applications and delayed-release formulations, since the 5-HT2B-antagonistic effectiveness can be achieved by, for example, lisuride even at a considerably lower concentration than the known and approved use of lisuride as dopamine agonist. This invention describes the use of 5-HT-2-receptor antagonists and especially of 8-α-ergolines such as lisuride (CAS-No.: 18016-80-3,3-(9,10-didehydro-6-methylergoline-8alpha-yl)-1,1-diethylurea), terguride (trans-dihydrolisuride) and derivatives thereof as 5-HT2B and 5-HT2A-receptor antagonists and antioxidants in higher-dosed and preferably continuous applications for treatment, progression prophylaxis, and general prophylaxis of organ fibroses, and other pathological organ remodeling caused by mesenchymal proliferation. These include primarily the secondary forms of pulmonary arterial high pressure, which can occur, for example, after COPD, infections, pulmonary fibrosis, right ventricular hypertrophy as a sequela of elevated pulmonary vascular pressure as well as the fibrotic remodeling of the liver, kidneys, skin or other organ systems. The invention further relates to salts, enantiomers, enantiomer mixtures, diastereomers, and diastereomer mixtures, hydrates, solvates, and racemates of the above-cited compounds for the production of a pharmaceutical preparation for treatment, progression prophylaxis, and general prophylaxis of organ fibroses and other organ remodeling caused by mesenchyme activation and collagen formation. These include primarily secondary forms of pulmonary high pressure, right ventricular hypertrophy as a result of elevated pulmonary vascular pressure and other organ fibroses, as well as the fibrotic remodeling of kidneys, liver, skin or other organs. The claimed compounds lisuride and terguride are alkaline and corresponding salts can be obtained by the addition of acid, whereby organic or inorganic acids can be used. The acids, which form this type of salt of the compounds according to general formula I, include sulfuric acid, sulfonic acid, phosphoric acid, nitrous acid, nitric acid, perchloric acid, hydrobromic acid, hydrochloric acid, formic acid, acetic acid, propionic acid, succinic acid, oxalic acid, glucuronic acid (in levorotatory and dextrorotatory form), lactic acid, malic acid, tartaric acid, (hydroxymalonic acid, hydroxypropanedicarboxylic acid), fumaric acid, citric acid, ascorbic acid, maleic acid, malonic acid, hydroxymaleic acid, pyruvic acid, phenylacetic acid, (o-, m-, p-) toluic acid, benzoic acid, p-amino-benzoic acid, salicylic acid, p-amino-salicylic acid, methylsulfonic acid, ethylsulfonic acid, hydroxymethylsulfonic acid, ethylenesulfonic acid, p-toluenesulfonic acid, naphthylsulfonic acid, naphthylaminosulfonic acid, sulfanilic acid, camphorsulfonic acid, quinic acid, o-methylmandelic acid, picric acid, (2,4,6-trinitrophenol), adipic acid, amino acids, such as, for example, methionine, tryptophans, arginine, and in particular acid amino acids such as glutamine or aspartic acid. When acid substituents are present in the compounds, basic addition salts can also be formed, in particular with alkali metals and also with amino acids. Therefore, alkali metal salts, such as sodium salt, potassium salt, or lithium salt, or magnesium salt, calcium salt, alkylamino salts or salts with amino acids can be formed with, e.g., alkaline amino acids such as lysines. This invention relates to the use of the strong and non-antagonizable 5-HT2B antagonist lisuride, its derivatives and other molecules of comparable action for the treatment or prevention of fibrotic organ changes and for the subsequent restructuring and normalization of affected organs and organ functions. Especially by the applications already proven in the case of lisuride in other indications (for example, by sc infusions using portable mini-pumps, by transdermal therapeutic systems, but also other depot forms), it is possible to ensure an inhibition of the trophic activation of fibroblasts, T cells and other mesenchymal cells completely and over the entire day and night and thus to prevent an intermittent activation of the 5-HT2 receptor subtypes as well as a possible “escape phenomenon” with ineffectiveness of treatment following therefrom. The same effect can also be achieved by higher-dosed oral applications and delayed-release formulations with good compatibility, since the 5-HT2B-antagonistic effectiveness can be achieved, for example, by lisuride already at considerably lower concentration than the known and allowed use of lisuride as a dopamine agonist. The above-cited and claimed active ingredients and substances are suitable for treatment, progression prophylaxis, and general prophylaxis of organ fibroses of, for example, the lungs and other organ remodeling caused by mesenchyme activation and collagen formation as well as for its normalization. That the substances of formula I for this use in organ fibroses are suitable is surprising to one skilled in the art. Previous manufacturer-approved products on the basis of lisuride (for example, Dopergine®) as prolactin reducing agents and Parkinson's agents and terguride (Teluron® in Japan) even warned against the triggering of fibrotic organ changes, such as heart valves, pleural or pericardial fibrosis as well as retropleural and retroperitoneal fibrosis, as possible undesirable side-effects of these substances, such as is also in fact known for substances with ergoline structure, for example for cabergoline, pergolide, ergotamine, and methylsergide. This knowledge has previously kept one skilled in the art from the newly found uses of the above-mentioned substances. A new finding that is relevant to achieving the desired therapeutic action is that a very short intermittent time interval of the action is adequate for the pro-fibrotic effects of 5-HT and that therefore a continuous use of 5-HT2B antagonists can best prevent or can inhibit in their progression the described organ fibroses for example by means of portable mini-pumps, transdermal systems with long-term release, implants or oral delayed-release forms. It is known that oral lisuride and terguride in their now-approved uses can also frequently trigger to some extent significant side-effects owing to their higher dosing and quick flooding. These include, for example, the orthostatic hypotension, which can result in circulatory failure and fainting and can also interfere with activities in normal life. Therefore, the manufacturers also warn against this side-effect. Such a side-effect is extremely undesirable in the case of pulmonary arterial high pressure and other organ fibroses, and it is also dangerous in the individual case. Also, for this reason, one skilled in the art would not get the idea of using such substances therapeutically in the described indications. Regarding this, the s.c. infusion with continuous action and lower daily dose is shown to be considerably superior according to the invention. The triggering of orthostatic hypotension and collapse by the described substances is also based on their known dopaminergic action like their previous therapeutic uses. It is also triggered like other common dopaminergic side-effects not by exceeding a critical dosage or plasma concentration but rather is caused by a widely varying, oscillating plasma level, primarily in the case of oral intake with quickly reached high peaks. In the case of extended use, it results in development of tolerance, which allows the therapeutic use in the described indications. The described side-effects can, however, be avoided to a very large extent anyway by the continuous forms of the use according to the invention, since here only inadequate fluctuations of the plasma level occur over time and also a “first-pass effect” is avoided in the liver. One use according to the invention of lisuride, terguride and derivatives thereof as 5-HT2B antagonists in the described forms of organ fibroses and comparable disease in mesenchyma is also facilitated, surprisingly enough, in that because of the higher affinity of the compounds according to the invention to the 5-HT receptor, in general lower dosages than for the known applications are therapeutically effective as dopamine agonists. This means that the general compatibility of these treatments is still more advantageous and thus also is distinguished clearly from the vasodilatory substances used to date. The use is also made very easy to use by the generally very low dosage of the described 5-HT2B antagonists, whose simple metabolism and in most cases also problem-free individual capacity to be metered is made very easy to use. These properties also facilitate the combination treatment, further embodied below, with other active ingredients for the same indication or for accompanying diseases, whereby also the very simple dose matching of the lisuridine infusion is another advantage. The claimed compounds lisuride, terguride and derivatives of formula (I) are especially suitable for the treatment or prophylaxis of pathological organ remodeling, such as is caused by 5-HT and/or by local, oxidative stress. These effects can be especially favorably used therapeutically by a constant substance action (for example by a continuous s.c. infusion) being achieved. The preferred application is therefore a continuous application. The use in the prophylaxis and/or treatment of the above-mentioned diseases of lisuride, terguride and derivatives of general formula (I) is carried out preferably such that during the entire treatment time, more than 90% of the time, preferably 100% of the time, the 5-HT2B- and/or 5-HT2A-receptor occupancy in the target organ is almost complete, but is preferably complete. In addition, the use in the prophylaxis and/or treatment of the above-mentioned diseases of lisuride, terguride and derivatives of general formula (I) is preferably carried out such that the active ingredient level in the systemic circulation of the organism during the treatment time, at least 80% of the time, preferably at least 90%, and most preferably 100% of the time continuously, is at least 5 pg/ml, more preferably at least 100 pg/ml, more preferably at least 200 pg/ml, and most preferably 300-500 pg/ml. The administration of lisuride, terguride and derivatives of general formula (I) in the prophylaxis and/or treatment of the above-mentioned diseases is preferably carried out at a dose of 0.01 to 5.0 mg per day, preferably 0.15 to 3.0 mg per day, and most preferably 0.25 to 1.0 mg per day. The administration of lisuride, terguride and derivatives of general formula (I) in the prophylaxis and/or treatment of the above-mentioned diseases is carried out preferably continuously, i.e., the active ingredient level is constant as much as possible during the entire treatment time, or primarily does not go below the above-mentioned active ingredient level during the entire treatment time. The administration according to the invention of lisuride, terguride and derivatives of general formula (I) for use in the propylaxis and/or treatment is carried out in one of the preferred embodiments on an organism, which suffers from elevated pulmonary arterial vascular pressure (PAH). In an embodiment of the invention, the PAH is the result of a disease that is selected from the group that includes COPD, infections, right ventricular hypertrophy, right-heart failure as a sequela of pulmonary hypertension, as well as other fibrotic changes in the lungs, liver, kidneys, skin or other organ systems. Lisuride and derivatives of lisuride of general formula (I) are most preferred as therapeutic substances and as active substances in pharmaceutical formulations, and lisuride according to formula (II), both 8α-lisuride and 8β-lisuride, is vastly preferred. In another embodiment of the invention, terguride and derivatives of terguride of general formula (I) are preferred as therapeutic substances and as active substances in pharmaceutical formulations; terguride according to formula (III) is more preferred. Subjects of this invention are also pharmaceutical preparations that contain lisuride, terguride and derivatives of general formula (I) for use in the prophylaxis and/or treatment of the above-described subjects of the invention. Pharmaceutical preparations can be selected according to the invention from the group of formulations including tablets, layer tablets, coated tablets, pills, soft or hardcapsules, microcapsules, oral delayed-release dosage forms, transdermal systems, suppositories, micro- and nanocrystalline formulations, liposomal formulations, drops, nose drops, sprays, emulsions, dispersions, solutions, sterile solutions, lyophilizates, powders and inhalation aerosols. The application or use of the pharmaceutical preparation according to the invention is preferably selected from the group that includes oral, peroral, sublingual, buccal, subcutaneous, intravenous, dermal, pulmonary or nasal use or application, whereby a subcutaneous use is most preferred. Also, the application of pharmaceutical preparations according to the invention is preferably a continuous application. Pharmaceutical preparations according to this invention, with an individual dose of lisuride or terguride or derivatives of general formula (I) in the range of 0.01 to 2.5 mg, are preferred, and depending on the severity of the disease, a daily dose for the patient is preferably in the range of 0.15 to 3.0 mg, most preferably in the range of 0.25 to 2.0 mg. A sterile solution is most preferred either as a lyophilizate for preparation of a sterile solution before use or as a ready-to-use sterile solution at a dosage of 0.25 to 1.0 mg for the continuous, preferably subcutaneous, infusion at an infusion rate of 0.05 to 50 mcg/h, preferably 1 to 20 mcg/h. In one embodiment of the invention, pharmaceutical preparations contain at least one of the claimed compounds, in particular lisuride or terguride or derivatives of general formula (I) at an individual dose of the active ingredients of 0.1 to 10 mg formulated with at least one pharmacologically compatible adjuvant, solvent, or carrier. Pharmaceutical preparations are preferably offered as sterile solutions or lyophilizates, parenteral, peroral and oral delayed-release dosage forms, transdermal systems, microcrystalline and nanocrystalline formulations, liposomal formulations, microcapsules, emulsions, and dispersions, and they are especially suitable for subcutaneous, intravenous, dermal, transdermal, oral, peroral or pulmonary use or application. Lactose, starch, sorbitol, mannitol, sucrose, ethyl alcohol and water can be used, for example, as pharmacologically and chemically compatible carriers, solvents or adjuvants. In addition, starches, modified starches, gelatins, natural sugars, natural or synthetic polymers, such as, for example, acacia gum, guar, sodium alginate, carboxymethyl cellulose or polyethylene glycol, can be included as binding agents. Cyclodextrins, modified cyclodextrins, also benzoates, chlorides, acetates, and tartrates can be included as stabilizers, and stearates, polyethylene glycol, amino acids, such as, for example, leucine, can be used as adjuvants, usually in concentrations of 0.05% to 15%. Liquid formulations include solutions, dispersions and emulsions. Liquid preparations for parenteral use are sterile and contain water or water and solubilizers, such as, for example, propylene glycol, micelle formers and mixed micelle formers. Starches or modified starches, alginates, aluminates, bentonites or microcrystalline cellulose can be used at concentrations of usually between 2% and 30% according to weight. Sugar, sugar alcohols, corn, rice or potato starches, gelatins, gum arabic, tragacanth sugar, ammonium calcium alginate, carboxymethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone and inorganic substances can be used as adjuvants usually at concentrations of between 1% to 30% according to weight. Pharmaceutical preparations for subcutaneous, intravenous and transdermal use just like parenteral and oral dosage forms with modified release are claimed as preferred formulations. Such formulations generally consist of a matrix, in particular a matrix with polymers, in many cases biodegradable polymers as shaping, constituting additives, in which at least one of the claimed compounds, preferably lisuride or terguride or derivatives of formula (I), is incorporated. The polymers cited below are claimed as examples of the above-mentioned matrix-constituting polymers: polyvalerolactone, polylactides, polyglycolides, copolymers of polylactides and polyglycolides, poly-e-caprolactone, poly-hydroxybutyric acid, polyhydroxyvalerate, poly(1,4-dioxane-2,3-dione), poly(1,3-dioxan-2-one), polyanhydrides such as polymaleic acid anhydride, polyhydroxymethacrylates, fibrin, polycyanoacrylates, polycaprolactone dimethyl acrylate, poly-b-maleic acid, polycaprolactonebutyl-acrylate, multiblock polymers, such as, by way of example, oligocaprolactone diols, and oligodioxanone diols, polyether ester-multiblock polymers such as, by way of example, PEG and poly(butylene terephthalate), polypivotolactones, polycaprolactone-glycolides, poly(g-ethyl glutamates), polyorthoesters, polytrimethyl carbonates, poly-iminocarbonates, poly(N-vinyl)-pyrrolidones, polyvinyl alcohols, polyester amides, glycolated polyesters, polyphosphoesters, polyphosphazenes, poly[p-carboxyphenoxy)propane], polyhydroxypentanoic acid, polyanhydrides, polyethylene oxide-propylene oxide, polyurethanes, polyurethanes with amino acid radicals in the skeleton, polyether esters such as polyethylene oxide, polyalkylene oxalates, polyorthoesters, and their copolymers, carrageenans, fibrinogen, starches, protein-based polymers, polyamino acids, synthetic polyamino acids, zein, modified zein, polyhydroxy-alkanoates, pectinic acid, modified and non-modified fibrin and casein, carboxymethyl sulfate, albumin, in addition hyaluronic acid, heparan sulfate, heparin, chondroitin sulfate, dextran, cyclodextrins, copolymers with PEG and polypropylene glycol, gum arabic, guar, gelatins, collagen, collagen-N-hydroxysuccinimide, modifications and copolymers and/or mixtures of these substances. Biopolymers are preferred, such as, for example, starch and denatured starch, cellulose, glycosaminoglycans, and collagen, as well as semi-synthetic and synthetic polymers such as silicones, silicone-elastomers, polydimethylsiloxane, polydimethylsiloxane containing silicon dioxide, polydimethyl siloxane containing polyalkylene oxide (Gelest®), polytetrafluoroethylene (Teflon®), polylactides, polyglycolides, polyethylene glycol, polylactide-polyglycolide copolymers, polyanhydrides, ethylene vinyl acetate polymers, poly(methyl methacrylate), cellulose ethyl ether, poly(ethyl acrylate), poly(trimethylammonium ethyl methacrylate), polydimethyl siloxanes, hydroxyethyl-polymethacrylates, polyurethanes and polystyrene-butadiene copolymers. Moreover, peroral dosage forms with modified release as well as transdermal systems can contain microspheres or nanoparticles or microcrystals or can contain the latter as constituent components and can contain at least one of the claimed compounds, preferably terguride and lisuride. The claimed particles or crystals can, moreover, be introduced into gels and can be applied in this form and also adhere to biocompatible ceramic materials such as hydroapatite. Within the framework of the current invention, the combination of lisuride, terguride or derivatives of formula (I) with at least one additional vasodilatory compound according to the invention is preferred. Within the framework of the current invention, the combination of lisuride, terguride or derivatives of formula (I) with at least one additional inhibitory compound according to the invention is preferred. Also, the application according to the invention of the above-cited combinations of lisuride, terguride or derivatives of formula (I) with the above-mentioned active ingredients according to the invention is preferably a continuous application. Within the framework of the current invention, the combination of lisuride with at least one additional vasodilatory compound according to the invention is especially preferred. Surprisingly enough, in addition to the pressure reduction (vasodilation) in the Arteria pulmonalis, accompanying, high-level pathogenetic mechanisms, such as, for example, endothelial lesions, the release of radicals and local thrombocyte aggregations but also permissive factors, such as, for example, BMP-R2-mutations, are also thus addressed according to the invention. Also, with the combination of lisuride with at least one vasodilatory compound, subsequent reactions of the elevated pulmonary pressure, such as hyperplasia of smooth vascular muscle cells and fibroblasts as well as fibrosis in general and ultimately a specific right-heart failure, are addressed according to the invention. With this background, lisuride, a surprisingly advantageous combination partner, which can engage the pathogenetic cascade at various points, is preferred according to the invention. Regarding this, advantages according to the invention are: i) As a strong peripheral 5-HT2A antagonist, lisuride inhibits the thrombocyte aggregation and thus the main causes of the locally intensified 5-HT release ii) As the strongest known 5-HT2B antagonist, lisuride blocks in addition with PAH the trophic 5-HT2B receptors and thus has an antifibrotic effect at the same time, thus against the progression or production of PAH iii) As highly effective free radical traps, lisuride also antagonizes free oxygen radicals, which are increased with PAH iv) At the same time, lisuride acts as a very strong antagonist on all alpha-adrenergic receptors and thus can the so-called Raynaud symptoms [sic], as they are frequently alleviated with PAH primarily in the case of skleroderma and primarily on the extremities; even so-called rat-bite necroses can be addressed by lisuride v) Moreover, lisuride, as a strong 5-HT2A antagonist, can also prevent or in any case weaken the pressure-induced proliferation of fibromyoblasts of the right heart, as they otherwise can lead, with PAH, to right-heart failure and ultimately to death With the context according to the invention, the combination of lisuride, terguride and their derivatives of formula (I) as 5-HT2B antagonists with known vasodilatory compounds, such as, i.a., prostacyclins and phosphodiesterase-5 antagonists, leads to surprising additive actions, preferably potentiated therapeutic actions. Also, a preferred embodiment according to the invention is the combination of lisuride, terguride and their derivatives of formula (I) as 5-HT2B antagonists with inhibitory compounds of soluble guanylate cyclase. Another preferred embodiment according to the invention is the combination of lisuride, terguride and their derivatives of formula (I) as 5-HT2B antagonists with inhibitory compounds of the TGF-beta-induced collagen synthesis, such as, for example, pirfenidone. In particular, a potentiated effectiveness (not just additive) of lisuride, terguride and their derivatives of formula (I) as 5-HT2B antagonists in combination with endothelin-1 antagonists, such as, i.a., bosentan, ambrisentan, larusentan, macitentan and sitaxsentan as vasodilatory compounds, is a preferred integral part of the current invention. In this regard, the TERPAH study (personal communication of R. Reiter, A. Ghofrani) has already shown that an orally administered 5-HT2B and 2A-antagonist terguride combination with added bosentan creates an average improvement of the pulmonary arterial pressure (PAH) by 200 dyn*sec*cm−5. In direct comparison, orally administered 5-HT2B and 5-HT2A-antagonist terguride combinations with a placebo only led to a pressure drop in PAH patients of between 40-70 dyn*sec*cm−5. The especially preferred combinations of lisuride with suitable PAH medications are surprisingly effective according to the invention, since the above-mentioned effects can be added or in individual cases can be potentiated. Suitable PAH medications as combination partners, most preferably with lisuride, are selected from a group of authorized preparations such as endothelin-1 antagonists, phosphodiesterase-5 inhibitors, phosphodiesterase-4 inhibitors and prostacyclins, but also stimulators of the soluble NO-guanylate cyclase, such as riociguat and, for example, adrenomedullin (ADM). In this connection, a combination with pirfenidone, an inhibitory compound of collagen synthesis, most preferably with lisuride, is also an integral part of the current invention. Another preferred embodiment with surprising superadditive effect follows from the combination of lisuride, terguride and their derivatives of formula (I) as 5-HT2B antagonist with sildenafil and other phosphodiesterase inhibitors according to the invention as inhibitory compounds according to the invention. In a preferred embodiment of the above-mentioned combinations, the pharmaceutically active substances according to the invention are selected from a group of lisuride, terguride and their derivatives of formula (I) as combination partners 1, administered at a dose of, for example, 0.1 to 0.6 mg of lisuride subcutaneously or 0.3 to 2.0 mg of terguride perorally per day, selected in combination with a combination partner 2 from a group of vasodilatory compounds, such as, for example, bosentan at at least 60 mg per day or, for example, sildenafil at at least 20 mg per day. In this connection, side-effects that may occur according to the invention are reduced. Vasodilatory compounds within the context of the invention are preferably the endothelin-1 antagonists sitaxsentan, ambrisentan, larusentan, bosentan, macitentan, atrasentan, BQ-123, zibotentan, and tezosentan. Also, vasodilatory compounds within the context of the invention are phosphodiesterase-5 inhibitors such as, for example, sildenafil and phosphodiesterase-4 inhibitors, such as, for example, rolipram and prostacyclins such as, for example, iloprost, treprostinil, as well as riociguat and the peptide adrenomedullin (ADM). Inhibitory compounds within the context of the invention are preferably pirfenidone and other inhibitors of collagen synthesis as well as imatinib and other tyrosine-kinase inhibitors. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need in order to extend life. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need, and during the treatment time, at least 80% of the time, preferably at least 100% of the treatment time, the 5-HT2B- and/or 5-HT2A-receptor occupancy in the target organ is at least 90%. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need, and during the entire treatment time, the 5-HT2B- and/or the 5-HT2A-receptor occupancy in the target organ is complete. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need, and the active ingredient level in the systemic circulation of the organism during the treatment time, at least 80% of the time, preferably 100% of the time continuously, is at least 5 pg/ml, more preferably at least 100 pg/ml, more preferably at least 200 pg/ml, and most preferably 300-500 pg/ml. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need at a dose of 0.01 to 5.0 mg per day, preferably 0.15 to 3.0 mg per day, and most preferably 0.25 to 1.0 mg per day. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered continuously to an organism in need. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered continuously to an organism in need at a daily dose of 0.01 to 5.0 mg, preferably 0.15 to 3.0 mg, and most preferably 0.25 to 2.0 mg. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need, and said organism suffers from elevated pulmonary vascular pressure (PAH). Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need, and said organism suffers from elevated pulmonary vascular pressure (PAH), which is a sequela of a disease selected from a group including CPOD, infections, right ventricular hypertrophy, and right-heart failure as a sequela of pulmonary hypertension (PAH), as well as other fibrotic changes in the lungs, liver, kidneys, skin or other organ systems. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need in combination with vasodilatory compounds. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need in combination with inhibitory compounds. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure are also subjects of this invention, whereby lisuride or terguride or a derivative of general formula (I) is administered to an organism in need in combination with vasodilatory compounds, i.a., selected from a group that contains sitaxsentan, ambrisentan, larusentan, bosentan, macitentan, atrasentan, BQ-123, zibotentan, tezosentan, sildenafil, iloprost, treprostinil, riociguat and adrenomedullin. Methods for the prophylaxis and/or treatment of fibrotic changes in organs and their vascular structure in a human or animal for impeding and/or for reversing said fibrotic changes in organs and their vascular structure
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