
In the time of 8/76 till 12/84 patients with operable carcinoma of the breast entered in a prospective study in which the value of postoperative radiation and adjuvant chemotherapy was to be tested. The composition of the series of patients studied is as follows: Upon multiple dosing with 20 or 40 mg over a period of 3 weeks, no serious side-effects and no influence on common laboratory parameters except a tentative increage in SHBG were observed. Pharmacokinetic investigations were concomitantly performed to obtain information on bioavailability (20 mg tabl. formulation). The substance was absorbed quickly and maximum concentration of 25 ng/ml (n= 4) was reached in 1.2h. The terminal half-life was calculated to be 25h and a bioavailability of 92% indicated that the tablet is almost as bioavailable as the reference solution. Preliminary results indicated after daily dosing of 20 mg Cytogent over a period of 3 weeks that the accumulation factor did not exceed 2 and 3 for parent drug and N-desmethyl metabolite, resp. Currently, multicenter studies evaluating antitumoral effect of Cytogent are underway.

Chirurgische Klinik Bad Cannstatt, Theodor-Veiel-Str.90, 7000 Stuttgart 50
Bre 14
MRI(Magnetic Resonance Imaging) of the Breast S.H.Hey~ang,W.Eiermann, G.Fenzl 150 patients have been examined by MR at our institution.50 of them have also been examined by MR after i.v.application of 0.2 mmol Gd-DTPA/kg as paramagnetic contrast agent. Compared to mammography the following advantages of plain MR have been Found: -improved visualisation of lesions close to the chest wall and of lesions behind silicon implants, -improved difFerentiation of well-circumscribed benign and ma lignant tumors based on their signal intensities on the T2-weighted images. Calculated T1-and T2-values did not Further improve the diagnostic ac curacy due to too much overlap. The major drawbacks of plain MR have been its inability to image mierocalcifications, high costs and long axa minstion times. The overall diagnostic accuracy of plain MR (150pts.)(sensitivity:88%,specificity:50%) ~as s]ightly inferior to mammography (sens.:9OZ,spec.: 62%). In the 50 patients examined by MR with Gd-DTPA the Following has been found:All benign and malignant tumors did enhance(including carcinomas with mierocalcificstions),whereas scar tissue and non-proliferative dysplasia did not enhance. Thus both the visualization of lesions (especially in dense breasts)and their differentiation were improved leading to a higher sensitivity and specificity (100%,73%) compared to mammography (76%,63%) and plain MR (74Z,75%). 8ased on our first experiences MR of the breast with Gd-D]PA may be especially helpful in patients with extensive-scarring,in patients with a prosthesis or other patients, where both clinical and radiologicsl examination are difficult. Klinikum GroBhadern,Univ. Mdnchen,Radiolog-Klinik Marchioninistr.15,DeO00
Bre 14
Mdnchen 70 This study is supported by the Dt. Krebshilfe.

{'paper_id': '29092535', 'title': 'Prospective, randomized study of adjuvant radiation and chemotherapy of operable carcinoma of the breast', 's2_url': 'https://api.semanticscholar.org/CorpusID:29092535', 'source': 'S2ORC'}