4-Hydroxymandelic acid

4-Hydroxymandelic acid is a chemical compound used to synthesize atenolol. The compound typically occurs as a monohydrate.

Synthesis and occurrence

It is produced from 4-hydroxypyruvic acid by the action of the enzyme (S)-p-hydroxymandelate synthase:

4-Hydroxymandelic acid can be synthesized by the condensation reaction of phenol and glyoxylic acid:
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