Title of Invention: Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer Abstract: Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof. Detailed Description: Part general_description_paragraphs: Part RELATED APPLICATIONS: This application is a divisional application of Ser. No. 11/688,789, filed Mar. 20, 2007, which published on Sep. 20, 2007 as U.S. patent application Publication 2007/0219276, to which priority is claimed under 35 U.S.C. §121, and which claims the benefit, pursuant to 35 U.S.C. §119(e), of U.S. Provisional Application No. 60/743,588, filed Mar. 20, 2006 each of which is herein incorporated by reference in its entirety. Part FIELD OF THE INVENTION: Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions that are zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Part BACKGROUND OF THE INVENTION: The importance of zinc in living systems has long been recognized. Zinc ions serve multiple biological functions that may be classified as catalytic, structural, or regulatory. The catalytic activity of zinc is due to its Lewis acidity, which serves to activate reactants as in well-described enzymatic mechanisms such as that of carboxypeptidase. Zinc plays a structural role in supporting higher order protein structure by coordinate interactions with cysteine or histidine residues, and examples such as those found in “zinc finger” type transcription factors are also well-known. However, the regulatory function of zinc, which relates to the effect of “free” zinc (defined here as loosely- and non-protein bound zinc) on processes such as cellular metabolism and transcription, remains a complex subject of considerable recent interest and discovery. For example, under oxidative stress conditions, cellular zinc release results in a multitude of pathologies on the organismal level. Zinc ionophores are capable of transporting zinc ions (hereinafter, simply referred to as zinc) between the extracellular environment and the intracellular environment. One example of a zinc ionophore is ZnHPT, 1-hydroxypyridine-2-thione, also known as pyrithione. ZnHPT has poor aqueous solubility. Part SUMMARY OF THE INVENTION: Described herein are zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility have increased bioavailability upon administration as compared to zinc ionophores, zinc chelators and/or zinc complexes with poor aqueous solubility. Also described herein are methods for synthesizing zinc ionophores, zinc chelators and/or zinc complexes. Described herein are also methods of treating cancer using at least one zinc ionophore, zinc chelator and/or zinc complex. In an aspect described herein, zinc ionophores can be used to treat cancer by delivering zinc to cancer cells. In another aspect described herein, zinc chelators can be used to treat cancer due to zinc chelation within the cancer cells by the unbound ligand. Also described herein are compositions and methods for treating cancer with combination of an expanded porphyrin metal complex and at least one zinc ionophore, zinc chelator and/or zinc complex or their respective pharmaceutically acceptable derivatives. In certain embodiments, the expanded porphyrin metal complex is a texaphyrin metal complex. In certain embodiments, the texaphyrin metal complex is a texaphyrin gadolinium complex. In certain embodiments, the texaphyrin is motexafin gadolinium (MGd). One aspect described herein relates to zinc ionophores or zinc complexes, comprising Formula (I): wherein: each R0, each R1, each R2, and each R3 on each side of Formula (I) is independently H, OH, NH2, NO2, CN, halogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, substituted lower cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, substituted aralkyl, substituted amino, alkoxy, substituted alkoxy, —S-(alkyl or substituted alkyl), —S(O)k(alkyl or substituted alkyl), where k is 1, 2, or 3, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —C(S)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), —O—CON(R′)-(alkyl or substituted alkyl), —CSN(R′)-(alkyl or substituted alkyl), —N(R′)CO-(alkyl or substituted alkyl), —N(R′)C(O)O-(alkyl or substituted alkyl), —N(R′)C(O)N(R′)-(alkyl or substituted alkyl), where each R′ is independently H, alkyl, or substituted alkyl; or L1XnL2-; provided that at least one of the R0, R1, R2, or R3 groups is L1XnL2-; each L1 is independently H, OH, NH2, halogen, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), alkyl, substituted alkyl, alkenyl, alkoxy, substituted alkoxy, alkylalkoxy, substituted alkylalkoxy, polyalkylene oxide, a hydroxylated group, a substituted hydroxylated group, substituted polyalkylene oxide, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, or substituted aralkyl; each X is independently a hydroxylated group, a substituted hydroxylated group, —O-(alkylene or substituted alkylene)-, —S-(alkylene or substituted alkylene)-, or —S(O)k(alkylene or substituted alkylene)-, where k is 1, 2, or 3; each n is an integral number selected from 1 to 20; each L2 is independently selected from the group consisting of a direct bond, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, —S—, —S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl, or substituted alkyl; optionally, at least one of R0, R1, R2, or R3 on one side of Formula (I) may be attached by L or L1XnL2- to at least one of R0, R1, R2, or R3 on the other side of Formula (I); L is selected from the group consisting of alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-, —O-(alkylene or substituted alkylene)-O—, —S—, —S-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S(O)k-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S—S-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-S—S-(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl or substituted alkyl; and pharmaceutically acceptable salts, pharmaceutically acceptable atropisomers, pharmaceutically active metabolites, pharmaceutically acceptable prodrugs, and pharmaceutically acceptable solvates. In one embodiment is a compound of Formula (I) wherein each of R0, R1, R2, and R3 is independently H, alkyl (CH2)v—ORy, ORy, NHRy, C(O)NHRy, wherein Ry is PEG or PPG; wherein PEG or PPG is —(O-alkylene or O-substituted alkylene)x-O—Rz, or -(alkylene-O or substituted alkylene-O)x—Rz; wherein Rz is H or alkyl; v and x are independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20; and pharmaceutically acceptable salts, pharmaceutically acceptable atropisomers, pharmaceutically active metabolites, pharmaceutically acceptable prodrugs, and pharmaceutically acceptable solvates. In one embodiment is a compound of Formula (I) wherein each R0, R1, R2, and R3 are the same on each side of Formula (I). In another embodiment is a compound of Formula (I) wherein R3 is OPEG; wherein x is 3; and R0, R1, and R2 are H. In a further embodiment is a compound of Formula (I) wherein R1 is C(O)NHPEG; wherein x is 3; and R0, R2, and R3 are H. In yet a further embodiment is a compound of Formula (I) wherein R1 is CH2—OPEG; wherein x is 3; and R0R2, and R3 are H. In another embodiment is a compound of Formula (I) wherein R1 is CH2—OPEG; wherein x is 2; and R0, R2, and R3 are H. In one embodiment is a compound of Formula (I) wherein R1 is CH2—OPEG; wherein x is 1; and R0, R2, and R3 are H. In another embodiment is a compound of Formula (I) wherein R0 is CH3 and R3 is OPEG; wherein x is 1; and R1 and R2 are H. In a further embodiment is a compound of Formula (I) wherein R0 is CH3 and R3 is OPEG; wherein x is 2; and R1 and R2 are H. In yet a further embodiment is a compound of Formula (I) wherein R0 is CH3 and R3 is OPEG; wherein x is 3; and R1 and R2 are H. In one aspect is a compound, comprising Formula (Ib): wherein: each R0, each R1, each R2, and each R3 is independently H, OH, NH2, NO2, CN, halogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, substituted lower cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, substituted aralkyl, substituted amino, alkoxy, substituted alkoxy, —S-(alkyl or substituted alkyl), —S(O)k(alkyl or substituted alkyl), where k is 1, 2, or 3, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —C(S)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), —O—CON(R′)-(alkyl or substituted alkyl), —CSN(R′)-(alkyl or substituted alkyl), —N(R′)CO-(alkyl or substituted alkyl), —N(R′)C(O)O-(alkyl or substituted alkyl), —N(R′)C(O)N(R′)-(alkyl or substituted alkyl), where each R′ is independently H, alkyl, or substituted alkyl; or L1XnL2-; provided that at least one of the R0, R1, R2, or R3 groups is L1XnL2-; each L1 is independently H, OH, NH2, halogen, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), alkyl, substituted alkyl, alkenyl, alkoxy, substituted alkoxy, alkylalkoxy, substituted alkylalkoxy, polyalkylene oxide, a hydroxylated group, a substituted hydroxylated group, substituted polyalkylene oxide, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, or substituted aralkyl; each X is independently a hydroxylated group, a substituted hydroxylated group, —O-(alkylene or substituted alkylene)-, —S-(alkylene or substituted alkylene)-, or —S(O)k(alkylene or substituted alkylene)-, where k is 1, 2, or 3; each n is an integral number selected from 1 to 20; and each L2 is independently selected from the group consisting of a direct bond, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, —S—, —S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl, or substituted alkyl; and pharmaceutically acceptable salts, pharmaceutically acceptable atropisomers, pharmaceutically active metabolites, pharmaceutically acceptable prodrugs, and pharmaceutically acceptable solvates. In one aspect is a compound comprising Formula (II): wherein: each R0, each R1, and each R2, on each side of Formula (II) is independently H, OH, NH2, NO2, CN, halogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, substituted lower cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, substituted aralkyl, substituted amino, alkoxy, substituted alkoxy, —S-(alkyl or substituted alkyl), —S(O)k(alkyl or substituted alkyl), where k is 1, 2, or 3, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —C(S)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), —O—CON(R′)-(alkyl or substituted alkyl), —CSN(R′)-(alkyl or substituted alkyl), —N(R′)CO-(alkyl or substituted alkyl), —N(R′)C(O)O-(alkyl or substituted alkyl), —N(R′)C(O)N(R′)-(alkyl or substituted alkyl), where each R′ is independently H, alkyl, or substituted alkyl; or L1XnL2-; each L1 is independently H, OH, halogen, alkyl, substituted alkyl, alkenyl, alkoxy, substituted alkoxy, alkylalkoxy, substituted alkylalkoxy, polyalkylene oxide, a hydroxylated group, a substituted hydroxylated group, substituted polyalkylene oxide, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, or substituted aralkyl; each X is independently a hydroxylated group, a substituted hydroxylated group, —O-(alkylene or substituted alkylene)-, —S-(alkylene or substituted alkylene)-, or —S(O)k(alkylene or substituted alkylene)-, where k is 1, 2, or 3; each n is an integral number selected from 1 to 20; j is 0 or 1; each L2 is independently selected from the group consisting of a direct bond, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, —S—, —S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl, or substituted alkyl; and L is selected from the group consisting of a bond, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)m-, —O-(alkylene or substituted alkylene)-O—, —S—, —S-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S(O)k-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S—S-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-S—S-(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl, or substituted alkyl; m is an integral number selected from 1 to 20; and pharmaceutically acceptable salts, pharmaceutically acceptable atropisomers, pharmaceutically active metabolites, pharmaceutically acceptable prodrugs, and pharmaceutically acceptable solvates. In one embodiment is a compound of Formula (II) wherein j is 0; L is a bond; and R0, R1, and R2 are H. In another embodiment is a compound of Formula (II) wherein L is (CH2OCH2)m, wherein m is an integral number from 0-4; j is 1, and R0, R1, and R2 are H. In one embodiment is a pharmaceutical composition comprising a compound of Formula (I) and a pharmaceutically acceptable excipient. In another embodiment is a pharmaceutical composition comprising a compound of Formula (II) and a pharmaceutically acceptable excipient. In one aspect is a method of treating cancer comprising administering to a patient in need a therapeutically effective amount of at least one compound having the structure of Formula (I): wherein: each R0, each R1, each R2, and each R3 on each side of Formula (I) is independently OH, NH2, NO2, CN, halogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, substituted lower cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, substituted aralkyl, substituted amino, alkoxy, substituted alkoxy, —S-(alkyl or substituted alkyl), —S(O)k(alkyl or substituted alkyl), where k is 1, 2, or 3, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —C(S)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), —O—CON(R′)-(alkyl or substituted alkyl), —CSN(R′)-(alkyl or substituted alkyl), —N(R′)CO-(alkyl or substituted alkyl), —N(R′)C(O)O-(alkyl or substituted alkyl), —N(R′)C(O)N(R′)-(alkyl or substituted alkyl), where each R′ is independently H, alkyl, or substituted alkyl; or L1X1L2-; provided that at least one of the R0, R1, R2, or R3 groups is L1XnL2-; each L1 is independently H, OH, NH2, halogen, —C(O)-(alkyl or substituted alkyl), —C(O)O-(alkyl or substituted alkyl), —OC(O)-(alkyl or substituted alkyl), —CON(R′)-(alkyl or substituted alkyl), alkyl, substituted alkyl, alkenyl, alkoxy, substituted alkoxy, alkylalkoxy, substituted alkylalkoxy, polyalkylene oxide, a hydroxylated group, a substituted hydroxylated group, substituted polyalkylene oxide, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkaryl, substituted alkaryl, aralkyl, or substituted aralkyl; each X is independently a hydroxylated group, a substituted hydroxylated group, —O-(alkylene or substituted alkylene)-, —S-(alkylene or substituted alkylene)-, or —S(O)k(alkylene or substituted alkylene)-, where k is 1, 2, or 3; each n is an integral number selected from 1 to 20; each L2 is independently selected from the group consisting of a direct bond, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, —S—, —S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl, or substituted alkyl; optionally, at least one of R0, R1, R2, or R3 on one side of Formula (I) may be attached by L or L1XnL2- to at least one of R0, R1, R2, or R3 on the other side of Formula (I); L is selected from the group consisting of alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, —O—, —O-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-, —O-(alkylene or substituted alkylene)-O—, —S—, —S-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S-(alkylene or substituted alkylene)-, —S(O)k— where k is 1, 2, or 3, —S(O)k(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S(O)k-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-S—S-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-S—S-(alkylene or substituted alkylene)-O-(alkylene or substituted alkylene)-, —C(O)—, —C(O)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-C(O)-(alkylene or substituted alkylene)-, —C(S)—, —C(S)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-C(S)-(alkylene or substituted alkylene)-, —N(R′)2—, —NR′-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-NR′-(alkylene or substituted alkylene)-, —C(O)N(R′)—, —CON(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-CON(R′)-(alkylene or substituted alkylene)-, —O—CON(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-O—CON(R′)-(alkylene or substituted alkylene)-, —CSN(R′)—, —CSN(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-CSN(R′)-(alkylene or substituted alkylene)-, —N(R′)CO-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)CO-(alkylene or substituted alkylene)-, —N(R′)C(O)O—, —N(R′)C(O)O-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)C(O)O-(alkylene or substituted alkylene)-, —S(O)kN(R′)—, —N(R′)C(O)N(R′)—, —N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, -(alkylene or substituted alkylene)-N(R′)C(O)N(R′)-(alkylene or substituted alkylene)-, —N(R′)C(S)N(R′)—, —N(R′)S(O)kN(R′)—, and —C(R′)2—N(R′)—N(R′)—; where each R′ is independently H, alkyl, or substituted alkyl; and pharmaceutically acceptable salts, pharmaceutically acceptable atropisomers, pharmaceutically active metabolites, pharmaceutically acceptable prodrugs, and pharmaceutically acceptable solvates. In one embodiment is a method of treating cancer further comprising the step of administering to a patient in need a therapeutically effective amount of motexafin gadolinium or a pharmaceutically acceptable texaphrin derivative. In one embodiment is a method of treating cancer comprising administering to a patient in need a compound of Formula (I) wherein the cancer is selected from the group consisting of adrenal cortical cancer, anal cancer, aplastic anemia, bile duct cancer, bladder cancer, bone cancer, bone metastasis, adult CNS brain tumors, pediatric CNS brain metastases, brain metastases, breast cancer, Castleman Disease, cervical cancer, childhood Non-Hodgkin's lymphoma, colon and rectum cancer, endometrial cancer, esophagus cancer, Ewing's family of tumors, eye cancer, gallbladder cancer, gastrointestinal carcinoid tumors, gastrointestinal stromal tumors, gestational trophoblastic disease, hematological malignancies, Hodgkin's disease, Kaposi'sarcoma, kidney cancer, laryngeal and hypopharyngeal cancer, acute lymphocytic leukemia, acute myeloid leukemia, children's leukemia, chronic lymphocytic leukemia, chronic myeloid leukemia, liver cancer, lung cancer, lung carcinoid tumors, Non-Hodgkin's lymphoma, male breast cancer, malignant mesothelioma, multiple myeloma, myelodysplastic syndrome, nasal cavity and paranasal cancer, nasopharyngeal cancer, neuroblastoma, oral cavity and oropharyngeal cancer, osteosarcoma, ovarian cancer, pancreatic cancer, penile cancer, pituitary tumor, prostate cancer, retinoblastoma, rhabdomyosarcoma, salivary gland cancer, sarcoma (adult soft tissue cancer), melanoma skin cancer, nonmelanoma skin cancer, stomach cancer, testicular cancer, thymus cancer, thyroid cancer, uterine sarcoma, vaginal cancer, vulvar cancer, and Waldenstrom's macroglobulinemia. In one embodiment, the cancers are selected from the group consisting of metastatic brain cancer, lung cancer, glioblastoma, lymphomas, leukemia, renal cell cancer (kidney cancer), head and neck cancer, breast cancer, prostrate cancer, and ovarian cancer. Another aspect described herein are pharmaceutical compositions comprising at least one zinc ionophore and/or zinc complex having a structure selected from Formula (I), Formula (II), or Formula (III); and a pharmaceutically acceptable excipient. In one embodiment, the pharmaceutical composition is suitable for intravenous administration or administration by injection. In one embodiment, the pharmaceutical composition comprises water. In another embodiment the pharmaceutical composition comprises a cyclodextrin. Another aspect described herein are zinc chelators having the structure of the group coordinating the zinc ion in structures of Formula (I), Formula (II), or Formula (III). Such zinc chelators include neutral structures or salt structures, wherein the counterion is any cation other than zinc. Thus, in any of the examples described herein (which describe the use of a zinc chelator) are included zinc chelators coordinated to a labile ion, such as sodium, potassium, or calcium, in which the labile ion can be replaced by zinc following administration of the non-zinc coordinated zinc chelator to the patient. Further, for zinc chelators or zinc ionophores capable of binding to multiple zinc ions are included mixed metal complexes in which the zinc chelator binds to different metal ions, or in the case of a zinc ionophore, binds to at least one zinc ion and one other metal ion. Another aspect described herein are pharmaceutical compositions comprising at least one such zinc chelator; and a pharmaceutically acceptable excipient. In one embodiment, the pharmaceutical composition is suitable for intravenous administration or administration by injection. In one embodiment, the pharmaceutical composition comprises water. Another aspect described herein relates to methods of enhancing solubility of an ionophore and/or chelator comprising the step of modifying at least one group of the ionophore and/or chelator with an optionally substituted PEG group or hydroxylated group. In some embodiments, the ionophore is a zinc ionophore. In some embodiments, the ionophore is an ionophore for a first row transition metal. In some embodiments, the ionophore for a first row transition metal is an ionophore for Mn(II), Mn(III), Fe(II), Fe(III), Co(II), Co(III), Cu(I), or Cu(II). In some embodiments, the zinc ionophore has a structure of Formula (I). In some embodiments the unmodified zinc ionophore is ZnHPT. In some embodiments, the modification with polyethylene glycol increases bioavailability of the zinc ionophore as compared to unmodified zinc ionophore. Another aspect described herein relates to methods of enhancing the biological activity of an ionophore and/or chelator comprising the step of modifying at least one group of the ionophore and/or chelator with an electron-withdrawing or electron-donating (more likely) group. In some embodiments, the ionophore is a zinc ionophore. In some embodiments, the ionophore is an ionophore for a first row transition metal. In some embodiments, the ionophore for a first row transition metal is an ionophore for Mn(II), Mn(III), Fe(II), Fe(III), Co(II), Co(III), Cu(I), or Cu(II). In some embodiments, the zinc ionophore has a structure of Formula (I). In some embodiments, the unmodified zinc ionophore is ZnHPT. An aspect also described herein relates to a method of treating cancer comprising the step of administering a therapeutically effective amount of at least one ionophore and/or chelator or their respective pharmaceutically acceptable derivatives, wherein the ionophore has at least one functional group selected from polyalkylene oxide, hydroxylated group, or a group having at least one amine, ammonium salt, carboxylate, sulfanyl, sulfinyl, sulfonyl, phosphate, phosphonate, phosphite; or combinations thereof. In some embodiments, the ionophore is an ionophore for a first row transition metal. In some embodiments, the ionophore for a first row transition metal is an ionophore for Mn(II), Mn(III), Fe(II), Fe(III), Co(II), Co(III), Cu(I), or Cu(II). An aspect also described herein relates to a method of treating cancer comprising the step of administering a therapeutically effective amount of at least one zinc ionophore and/or zinc chelator or their respective pharmaceutically acceptable derivatives (including, for example chelate complexes of a zinc chelator, in which the zinc chelator coordinates a labile ion, e.g., sodium, potassium or calcium ions), wherein the zinc ionophore and/or zinc chelator has at least one functional group selected from polyalkylene oxide, hydroxylated group, or a group having at least one amine, ammonium salt, carboxylate, sulfanyl, sulfinyl, sulfonyl, phosphate, phosphonate, phosphite; or combinations thereof. In some embodiments, the zinc ionophore has the structure of any compound having the structure of Formula (I), Formula (II), Formula (III), or Formula (IV). In some embodiments, the zinc chelator has the structure of the group coordinating zinc in the structures of Formula (I), Formula (II), Formula (III), or Formula (IV). In some embodiments, the zinc ionophore has a mixed structure in which it is chelated by two different zinc chelators, at least one of which has the structure of the group coordinating zinc in the structures of Formula (I), Formula (II), Formula (III), or Formula (IV). In some embodiments, the zinc ionophore and/or chelator has an aqueous solubility greater than about 1 millimolar, greater than about 2 millimolar, greater than about 3 millimolar, greater than about 4 millimolar, greater than about 5 millimolar or greater than about 6 millimolar. In some embodiments, the zinc ionophore and/or zinc chelator increases intracellular zinc concentration. In some embodiments, the zinc ionophore and/or zinc chelator chelates zinc within the cancer cells. In some embodiments, the zinc ionophore and/or zinc chelator functions to modulate zinc homeostasis in vivo. In some embodiments, the zinc ionophore and/or zinc chelator is modified with at least one polyethylene glycol group. In some embodiments, the zinc ionophore and/or zinc chelator is modified with at least one hydroxylated group. In some embodiments, the zinc ionophore is ZnHPT modified with at least one polyethylene glycol group. In some embodiments, the zinc ionophore is ZnHPT modified with at least one hydroxylated group. In some embodiments, the zinc ionophore and/or zinc chelator comprises a disulfide bond. In some embodiments, the disulfide bond is reduced within cancer cells. Another aspect described herein relates to a method of treating cancer comprising administering to a patient in need thereof: (a) a therapeutically effective amount of motexafin gadolinium or a pharmaceutically acceptable texaphyrin derivative; and (b) a therapeutically effective amount of at least one zinc ionophore and/or zinc chelator or their respective pharmaceutically acceptable derivatives. In some embodiments, the motexafin gadolinium and the zinc ionophore and/or zinc chelator are sequentially administered to the patient. In some embodiments, the motexafin gadolinium and the zinc ionophore and/or zinc chelator are simultaneously administered to the patient. In some embodiments, the motexafin gadolinium and the zinc ionophore and/or zinc chelator are in a single formulation. In some embodiments, there is a synergistic combination between the motexafin gadolinium and the zinc ionophore and/or zinc chelator or their respective pharmaceutically acceptable derivatives. In some embodiments, the administration is performed using an intravenous injection or infusion. Another aspect described herein relates to pharmaceutical compositions comprising (a) a therapeutically effective amount of motexafin gadolinium or a pharmaceutically acceptable texaphyrin derivative; and (b) a therapeutically effective amount of at least one zinc ionophore and/or zinc chelator or their respective pharmaceutically acceptable derivatives. Another aspect described herein relates to an anticancer agent comprising an expanded porphyrin metal complex chemically linked via a linker group to a zinc ionophore and/or zinc chelator. In some embodiments, the zinc ionophore has the structure of the compounds of Formula (I), Formula (II), or Formula (III). In some embodiments, the zinc chelator has the structure of the group coordinating to the zinc ion in the compounds of Formula (I), Formula (II), or Formula (III). In some embodiments, the expanded porphyrin metal complex is a texaphyrin metal complex. In another aspect, the zinc ionophore and/or zinc complex is a dipyrromethene (including derivatives thereof) bound to a zinc cation, or the zinc chelator is a dipyrromethene (includes derivatives thereof) that can bind a zinc cation. Further, any of the methods described herein, including methods for treating cancer can be used with such a zinc ionophore and/or zinc chelator. Part INCORPORATION BY REFERENCE: Unless stated otherwise, all publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. Part DETAILED DESCRIPTION OF THE INVENTION: Zinc exists exclusively in the divalent state, and is therefore intrinsically redox-inactive. Zinc is nonetheless an active participant in redox chemistry as a consequence of its coordination environment: Wherever bound by two or more thiol ligands, the potential exists for ligand oxidation to form a disulfide with concomitant zinc release. Normally, the concentration of intracellular free zinc is maintained at a vanishingly low value. However, it is significantly increased by the release of zinc under conditions of oxidative stress. For example, increased free zinc has been measured in cells treated with hydrogen peroxide or nitric oxide. Thus, the level of intracellular free zinc is intimately connected to the redox state of the cell, although this level may be altered by other processes, including the exogenous administration of zinc. This is particularly evident in neurological indications such as stroke, ALS, and AD. In animal models of stroke, for example, administration of zinc-binding chelators has been reported to reduce the degree of tissue damage surrounding induced ischemic lesions. In oncology, efforts are being made to correlate tumor metallothionein levels with clinical outcomes. This approach may be particularly germane in prostate and pancreatic cancer, given the unusually high zinc levels normally found in these tissues. It is now known that increased levels of free zinc are, inevitably, a by-product of oxidative stress. Increased free zinc can impact cellular metabolic and signaling functions, and appears to be involved in several human diseases, including cancer. The cellular response to free zinc on the transcriptional level is mediated by the metal responsive transcription factor MTF-1, which induces the expression of metallothioneins and zinc transporters. Metallothioneins (or more properly, thioneins) are zinc-binding proteins that serve to chaperone zinc, restoring a low free zinc level. Zinc transporters also help to maintain homeostasis, by transporting zinc across plasma or other cellular membranes. Described herein are zinc ionophores, zinc chelators and/or zinc complexes which modulate intracellular free zinc to deliver therapeutic benefit by inducing oxidative stress or altering energy metabolism. In general, the following criteria are important in the design of a zinc ionophore for treating cancer: (1) aqueous solubility to facilitate administration and bioavailability; (2) lipid solubility—to facilitate cell entry; (3) high binding affinity to zinc—the complex does not lose an appreciable portion of bound zinc to serum proteins present in the plasma or interstitial fluid; (4) lability—sufficiently low stability within cells to release zinc. We had previously found that MGd increased intracellular free zinc in cancer cells, presumably as a consequence of oxidation reactions involving thiols coordinated to zinc, and had observed synergistic inhibition of thioredoxin reductase in cells that were co-treated with ZnHPT, a known zinc ionophore. ZnHPT has been reported to inhibit the growth of cancer cells in culture, but is not appropriate for in vivo administration due to its limited solubility in aqueous media. Certain Definitions The phrase “pharmaceutical agent” as used herein, refers to any agent which imparts a therapeutic effect and is used or indicated for use as a pharmaceutical. Pharmaceutical agents may be used in the treatment, diagnosis, modulation, or prevention of a diseased state or symptom thereof. One of skill in the art is able to select appropriate pharmaceutical agents when addressing a particular disease or symptom. Exemplary pharmaceutical agents contemplated within the scope of the present disclosure are provided in the following references (the disclosures of all of which are hereby incorporated by reference): Lippincott et al., Remington's Pharmaceutical Sciences: The Science and Practice of Pharmacy, 20th Ed., Williams and Wilkins Publishing, Baltimore (2000); and Lewis et al., Hawley's Condensed Chemical Dictionary, 14th Ed., John Wiley Publishing, New York (2001). “Dispersing agents,” and/or “viscosity modulating agents” include materials that control the diffusion and homogeneity of a drug through liquid media or a granulation method or blend method. In some embodiments, these agents also facilitate the effectiveness of a coating or eroding matrix. Exemplary diffusion facilitators/dispersing agents include, e.g., hydrophilic polymers, electrolytes, Tween® 60 or 80, PEG, polyvinylpyrrolidone (PVP; commercially known as Plasdone®), and the carbohydrate-based dispersing agents such as, for example, hydroxypropyl celluloses (e.g., HPC, HPC-SL, and HPC-L), hydroxypropyl methylcelluloses (e.g., HPMC K100, HPMC K4M, HPMC K15M, and HPMC K100M), carboxymethylcellulose sodium, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate stearate (HPMCAS), noncrystalline cellulose, magnesium aluminum silicate, triethanolamine, polyvinyl alcohol (PVA), vinyl pyrrolidone/vinyl acetate copolymer (S630), 4-(1,1,3,3-tetramethylbutyl)-phenol polymer with ethylene oxide and formaldehyde (also known as tyloxapol), poloxamers (e.g., Pluronics F68®, F88®, and F108®, which are block copolymers of ethylene oxide and propylene oxide); and poloxamines (e.g., Tetronic 908®, also known as Poloxamine 908®, which is a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine (BASF Corporation, Parsippany, N.J.)), polyvinylpyrrolidone K12, polyvinylpyrrolidone K17, polyvinylpyrrolidone K25, or polyvinylpyrrolidone K30, polyvinylpyrrolidone/vinyl acetate copolymer (S-630), polyethylene glycol, e.g., the polyethylene glycol can have a molecular weight of about 300 to about 6000, or about 3350 to about 4000, or about 7000 to about 5400, sodium carboxymethylcellulose, methylcellulose, polysorbate-80, sodium alginate, gums, such as, e.g., gum tragacanth and gum acacia, guar gum, xanthans, including xanthan gum, sugars, cellulosics, such as, e.g., sodium carboxymethylcellulose, methylcellulose, sodium carboxymethylcellulose, polysorbate-80, sodium alginate, polyethoxylated sorbitan monolaurate, polyethoxylated sorbitan monolaurate, povidone, carbomers, polyvinyl alcohol (PVA), alginates, chitosans and combinations thereof. Plasticizcers such as cellulose or triethyl cellulose can also be used as dispersing agents. Dispersing agents particularly useful in liposomal dispersions and self-emulsifying dispersions are dimyristoyl phosphatidyl choline, natural phosphatidyl choline from eggs, natural phosphatidyl glycerol from eggs, cholesterol and isopropyl myristate. “Diluents” increase bulk of the composition to facilitate compression or create sufficient bulk for homogenous blend for capsule filling. Such compounds include e.g., lactose, starch, mannitol, sorbitol, dextrose, microcrystalline cellulose such as Avicel®; dibasic calcium phosphate, dicalcium phosphate dihydrate; tricalcium phosphate, calcium phosphate; anhydrous lactose, spray-dried lactose; pregelatinized starch, compressible sugar, such as Di-Pac® (Amstar); mannitol, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose acetate stearate, sucrose-based diluents, confectioner's sugar; monobasic calcium sulfate monohydrate, calcium sulfate dihydrate; calcium lactate trihydrate, dextrates; hydrolyzed cereal solids, amylose; powdered cellulose, calcium carbonate; glycine, kaolin; mannitol, sodium chloride; inositol, bentonite, and the like. The terms “pharmaceutically effective amount” or “effective amount” as used herein, refers to a nontoxic but sufficient amount of the agent to provide the desired biological, therapeutic, and/or prophylactic result. The desired results include reduction and/or alleviation of the signs, symptoms, or causes of a disease, or any other desired alteration of a biological system. An effective amount in any individual case may be determined by one of ordinary skill in the art using routine experimentation. In relation to a pharmaceutical agent, effective amounts can be dosages that are recommended in the modulation of a diseased state or symptom thereof. Effective amounts differ depending on the pharmaceutical agent used and the route of administration employed. Effective amounts are routinely optimized taking into consideration various factors of a particular patient, such as age, weight, gender, etc. The term “pharmaceutically acceptable” or “pharmacologically acceptable” as used herein, refers a material which is not biologically active or otherwise undesirable, i.e., the material may be administered to an individual without causing any undesirable biological effects or interacting in a deleterious manner with any of the components of the composition in which it is contained. “Pharmaceutically acceptable” also refers to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication commensurate with a reasonable benefit/risk ratio. “Pharmaceutically acceptable” also means that in a formulation containing the compound of Formula (I), Formula (Ia), Formula (Ib), Formula (II), Formula (Ia), Formula (III), Formula (IV), Formula (V), and Formula (Va), the carrier, diluent, excipients, and salt must be compatible with the other ingredients of the formulation, and not deleterious to the recipient thereof. As used herein, “pharmaceutically acceptable carrier” or “pharmaceutically acceptable excipient” includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, stabilizing agents, dispersing agents, viscosity-increasing agents, additives, and the like, depending on the dosage form used. Exemplary carrier or excipient materials include, e.g., binders, suspending agents, disintegration agents, filling agents, surfactants, solubilizers, stabilizers, lubricants, wetting agents, diluents, and the like. “Pharmaceutically compatible carrier materials” may comprise, but are not limited to, acacia, gelatin, colloidal silicon dioxide, calcium glycerophosphate, calcium lactate, cyclodextrin, amino acid carriers, protein carriers, detergents, maltodextrin, glycerine, magnesium silicate, polyvinylpyrrollidone (PVP), cholesterol, cholesterol esters, sodium caseinate, soy lecithin, taurocholic acid, phosphotidylcholine, sodium chloride, tricalcium phosphate, dipotassium phosphate, cellulose and cellulose conjugates, sugars sodium stearoyl lactylate, carrageenan, monoglyceride, diglyceride, pregelatinized starch, and the like. See, e.g., Remington: The Science and Practice of Pharmacy, Nineteenth Ed (Easton, Pa.: Mack Publishing Company, 1995); Hoover, John E., Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa. 1975; Liberman, H. A. and Lachman, L., Eds., Pharmaceutical Dosage Forms, Marcel Decker, New York, N.Y., 1980; and Pharmaceutical Dosage Forms and Drug Delivery Systems, Seventh Ed. (Lippincott Williams & Wilkins 1999). The use of such agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated. Supplementary active ingredients can also be incorporated into the compositions. The phrase “pharmaceutically acceptable derivatives” of a compound include salts, esters, enol ethers, enol esters, acetals, ketals, orthoesters, hemiacetals, hemiketals, acids, bases, solvates, hydrates or prodrugs thereof. Such derivatives may be readily prepared by those of skill in this art using known methods for such derivatization. The compounds produced may be administered to animals or humans without substantial toxic effects and either are pharmaceutically active or are prodrugs. Pharmaceutically acceptable salts include salts which retain the biological effectiveness and properties of the compounds of the present disclosure and which are not biologically or otherwise undesirable. In many cases, the compounds disclosed herein are capable of forming acid and/or base salts by virtue of the presence of amino and/or carboxyl groups or groups similar thereto. Pharmaceutically acceptable base addition salts can be prepared from inorganic and organic bases. Salts derived from inorganic bases, include by way of example only, sodium, potassium, lithium, ammonium, calcium and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary and tertiary amines, such as by way of example only, alkyl amines, dialkyl amines, trialkyl amines, substituted alkyl amines, di(substituted alkyl)amines, tri(substituted alkyl)amines, alkenyl amines, dialkenyl amines, trialkenyl amines, substituted alkenyl amines, di(substituted alkenyl)amines, tri(substituted alkenyl)amines, cycloalkyl amines, di(cycloalkyl)amines, tri(cycloalkyl)mines, substituted cycloalkyl amines, disubstituted cycloalkyl amines, trisubstituted cycloalkyl amines, cycloalkenyl amines, di(cycloalkenyl)amines, tri(cycloalkenyl)amines, substituted cycloalkenyl amines, disubstituted cycloalkenyl amines, trisubstituted cycloalkenyl amines, aryl amines, diaryl amines, triaryl amines, heteroaryl amines, diheteroaryl amines, triheteroaryl amines, heterocyclic amines, diheterocyclic amines, triheterocyclic amines, mixed di- and tri-amines where at least two of the substituents on the amine are different and are selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, heteroaryl, heterocyclic, and the like. Also included are amines where the two or three substituents, together with the amino nitrogen, form a heterocyclic or heteroaryl group. Pharmaceutically acceptable acid addition salts may be prepared from inorganic and organic acids. The inorganic acids that can be used include, by way of example only, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. The organic acids that can be used include, by way of example only, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. The pharmaceutically acceptable salts of the compounds useful in the present disclosure can be synthesized from the parent compound, which contains a basic or acidic moiety, by conventional chemical methods. Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa. (1985), p. 1418, the disclosure of which is hereby incorporated by reference. Examples of such pharmaceutically acceptable salts are the iodide, acetate, phenyl acetate, trifluoroacetate, acrylate, ascorbate, benzoate, chlorobenzoate, dinitrobenzoate, hydroxybenzoate, methoxybenzoate, methylbenzoate, o-acetoxybenzoate, naphthalene-2-benzoate, bromide, isobutyrate, phenylbutyrate, γ-hydroxybutyrate, β-hydroxybutyrate, butyne-1,4-dioate, hexyne-1,4-dioate, hexyne-1,6-dioate, caproate, caprylate, chloride, cinnamate, citrate, decanoate, formate, fumarate, glycollate, heptanoate, hippurate, lactate, malate, maleate, hydroxymaleate, malonate, mandelate, mesylate, nicotinate, isonicotinate, nitrate, oxalate, phthalate, terephthalate, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate, propiolate, propionate, phenylpropionate, salicylate, sebacate, succinate, suberate, sulfate, bisulfate, pyrosulfate, sulfite, bisulfite, sulfonate, benzenesulfonate, p-bromophenylsulfonate, chlorobenzenesulfonate, propane sulfonate, ethanesulfonate, 2-hydroxyethanesulfonate, methanesulfonate, naphthalene-1-sulfonate, naphthalene-2-sulfonate, p-toluenesulfonate, xylenesulfonate, tartarate, and the like. Pharmaceutically acceptable esters include, but are not limited to, alkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl and heterocyclyl esters of acidic groups, including, but not limited to, carboxylic acids, phosphoric acids, phosphinic acids, sulfonic acids, sulfinic acids and boronic acids. Pharmaceutically acceptable enol ethers include, but are not limited to, derivatives of formula C═C(OR) where R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl or heterocyclyl. Pharmaceutically acceptable enol esters include, but are not limited to, derivatives of formula C═C(OC(O)R) where R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl or heterocyclyl. Pharmaceutically acceptable solvates and hydrates are complexes of a compound with one or more solvent or water molecules, or 1 to about 100, or 1 to about 10, or one to about 2, 3 or 4, solvent or water molecules. The term “chemotherapy” as used herein, refers to the administration of one or more anti-cancer drugs and/or other agents to a cancer patient by various methods, including intravenous, intramuscular, intraperitoneal, intravesical, parenteral, or subcutaneous. The term “treating” and its grammatical equivalents as used herein, refer to achieving, or attempting to achieve, a therapeutic benefit and/or a prophylactic benefit. By therapeutic benefit is meant eradication or amelioration, at least in part, of the underlying disorder being treated. For example, in a cancer patient, therapeutic benefit includes eradication or amelioration, at least in part, of the underlying cancer. Also, a therapeutic benefit includes the eradication or amelioration, at least in part, of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the patient, notwithstanding the fact that the patient may still be afflicted with the underlying disorder. For prophylactic benefit, a method disclosed herein may be performed on, or a composition disclosed herein administered to, a patient at risk of developing cancer, or to a patient reporting one or more of the physiological symptoms of such conditions, even in the absence of a diagnosis of the condition. Specifically, the term “treatment” or “treating” includes: a) preventing the disease, that is, causing the clinical symptoms of the disease not to develop; b) inhibiting the disease, that is, arresting the development of clinical symptoms; and/or c) relieving the disease, that is, causing the regression of clinical symptoms. The term “therapeutically effective amount” is intended to include an amount of a compound useful in the present disclosure or an amount of the combination of compounds claimed. The combination of compounds is preferably a synergistic combination. Synergy, as described for example by Chou and Talalay, Adv. Enzyme Regul. 22:27-55 (1984), occurs when the effect of the compounds when administered in combination is greater than the additive effect of the compounds when administered alone as a single agent. In general, a synergistic effect is most clearly demonstrated at suboptimal concentrations of the compounds. Synergy can be in terms of lower cytotoxicity, increased activity, or some other beneficial effect of the combination compared with the individual components. The term “synergistic combination” refers to a synergistic effect of a combination of compounds for enabling administration at a lower amount of any compound than its full strength amount without the combination for achieving a similar therapeutic effect. Alternatively, “synergistic combination” also refers to a compound's capability to mitigate adverse effects associated with another compound. Accordingly, the compound with mitigated adverse effects can be administered to provide a stronger therapeutic effect at a similar level of adverse effect without the combination. The term “acyl” refers to moieties having the formula R—C(O)—, wherein such moieties include, but are not limited to HC(O)—, alkyl-C(O)—, substituted alkyl-C(O)—, amino-C(O)—, substituted amino-C(O)—, cycloalkyl-C(O)—, substituted cycloalkyl-C(O)—, cycloalkenyl-C(O)—, substituted cycloalkenyl-C(O)—, alkenyl-C(O)—, substituted alkenyl-C(O)—, aryl-C(O)—, substituted aryl-C(O)—, heteroaryl-C(O)—, substituted heteroaryl-C(O)—, heterocyclic-C(O)—, substituted heterocyclic-C(O)—; where alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, amino, substituted amino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. Aminoacyl groups are sometimes also referred to as amides. The term “acyloxy” refers to moieties having the formula R—C(O)O—, wherein such moieties include, but are not limited to HC(O)—, alkyl-C(O)O—, substituted alkyl-C(O)O—, amino-C(O)O—, substituted amino-C(O)O—, cycloalkyl-C(O)O—, substituted cycloalkyl-C(O)O—, cycloalkenyl-C(O)O—, substituted cycloalkenyl-C(O)O—, alkenyl-C(O)O—, substituted alkenyl-C(O)O—, aryl-C(O)O—, substituted aryl-C(O)O—, heteroaryl-C(O)O—, substituted heteroaryl-C(O)O—, heterocyclic-C(O)O—, substituted heterocyclic-C(O)O—; where alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, amino, substituted amino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. The term “alkaryl” refers to the groups-optionally substituted alkylene-optionally substituted aryl, where alkylene, substituted alkylene, aryl and substituted aryl are defined herein. Such alkaryl groups are exemplified by benzyl, phenethyl and the like. The term “alkenyl” refers to a monoradical of a branched or unbranched unsaturated hydrocarbon group having from 2 to 20 carbon atoms, having 2 to 10 carbon atoms and 2 to 6 carbon atoms and having at least from 1-6 sites of vinyl unsaturation. Alkenyl groups include ethenyl (—CH═CH2), 1-propylene (—CH2CH═CH2), isopropylene [—C(CH3)═CH2], and the like. The term “optionally substituted alkenyl” refers to an alkenyl group in which at least 1 hydrogen atom has been replaced by a substituent selected from ═O, ═S, acyl, acyloxy, alkoxy, substituted alkoxy, amino, substituted amino, aryl, substituted aryl, aryloxy, substituted aryloxy, carboxyl, (optionally substituted alkoxy)carbonyl, (optionally substituted amino)carbonyl, (optionally substituted alkoxy)carbonyloxy, (optionally substituted amino)carbonyloxy, cyano, halogen, hydroxyl, nitro, phosphine, phosphonato, phosphono, sulfanyl, sulfinyl, sulfonyl, substituted phosphine, substituted phosphonato, substituted phosphono, substituted sulfanyl, substituted sulfinyl, substituted sulfonyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, acylamino, acyloxy, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxyl, keto, thioketo, carboxyl, carboxylalkyl, thioaryloxy, thioheteroaryloxy, thioheterocyclooxy, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heterocyclyl, substituted heterocyclyl, heterocyclooxy, substituted heterocyclooxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO2-alkyl, —SO2-substituted alkyl, —SO2-aryl and —SO2-heteroaryl. The term “alkenylene” refers to a diradical derived from the above-defined monoradical, alkenyl. This term is exemplified by groups such as ethenylene (—CH═CH—), the propenylene isomers (e.g., —CH2CH═CH— and —C(CH3)═CH—) and the like. The term “substituted alkenylene” refers to an alkenylene group as defined herein having from 1 to 5 substituents, and from 1 to 3 substituents, selected from the group consisting of alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxyl, keto, thioketo, carboxyl, carboxylalkyl, thioaryloxy, thioheteroaryloxy, thioheterocyclooxy, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO2-alkyl, —SO2-substituted alkyl, —SO2-aryl and —SO2-heteroaryl. Additionally, such substituted alkenylene groups include those where 2 substituents on the alkenylene group are fused to form one or more cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, heterocyclic or heteroaryl groups fused to the alkenylene group. The term “alkoxy” refers to moieties having the formula —O—R, wherein such moieties include, but are not limited to, —O-alkyl, —O-alkenyl, —O-cycloalkyl, —O-cycloalkenyl, —O-alkynyl. In addition, non-limiting examples of such —O-alkyl groups are methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, tert-butoxy, sec-butoxy, n-pentoxy, n-hexoxy, 1,2-dimethylbutoxy, and the like. The term “substituted alkoxy” refers to moieties having the formula —O-(substituted alkyl), —O-(substituted alkenyl), —O-(substituted cycloalkyl), —O-(substituted cycloalkenyl), —O-(substituted alkynyl), —O-(substituted alkylene)-alkoxy. Non-limiting examples of such —O-(substituted alkylene)-alkoxy, also referred to as “polyalkoxy”, are OCH2CH2OCH3, and polyethylene glycol (PEG) groups such as —O(CH2CH2O)xCH3, where x is an integer of about 1-20. Non-limiting examples of such —O-(substituted alkyl) groups are —OCH2(CH2)yOH, where y is an integer of about 1-10. In other examples, y is an integer of about 1-4. The term “alkoxyalkylene” refers to the groups: alkyl-O-alkylene-, (substituted alkyl)-O-alkylene-, alkyl-O-substituted alkylene-, (substituted alkyl)-O-(substituted alkylene). A non-limiting examples of such alkoxyalkylene group is -alkylene-O-alkyl and include, by way of example, methoxymethylene (—CH2OCH3), methoxyethylene (—CH2CH2OCH3), n-(iso-propoxy)propylene [—CH2CH2CH2OCH(CH3)2] and the like. The term “alkyl” refers to a monoradical branched, cyclic, or unbranched saturated hydrocarbon chain having from 1 to 20 carbon atoms,
{'bibliographic_information': "{'country': 'US', 'doc-number': '12410392', 'kind': 'B2', 'date': '20090324', 'extension': '59', 'invention_title': 'Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer'}", 'source_file': './grant/2010/ipg101123.xml', 'source_data': 'USPTO-Grant'}