Abstract
delayed in Rfx3-deficient lungs, which accounts for the defective septum formation. Migration assays performed on primary cell cultures of myofibroblasts from wild type and Rfx3À/À lungs show that Rfx3À/À myofibroblasts loose their capacities to respond to environmental factors as guidance cues. We are currently dissecting the signaling cascades that are impaired in Rfx3-deficient myofibroblasts. In conclusion, RFX3 regulates primary ciliary growth and governs myofibroblast differentiation program in the developing lungs. Our work therefore suggests a novel function of primary cilia during lung development in vivo. 

The kidney is an important organ to maintain waste-free and osmotically balanced blood in the circulation system. To accomplish these functions, different cell types in the specific locations have to be specified during development. In the zebrafish pronephros, two cell types, the multiple ciliated cells ( 

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