app.py

import os
import sys
import random
import gradio as gr
from multiprocessing import freeze_support
import importlib
import inspect

# === Fix import path BEFORE loading TxAgent
sys.path.insert(0, os.path.join(os.path.dirname(os.path.abspath(__file__)), "src"))

# === Reload to avoid stale cache
import txagent.txagent
importlib.reload(txagent.txagent)
from txagent.txagent import TxAgent

# === Debug confirmation
print(">>> TxAgent loaded from:", inspect.getfile(TxAgent))
print(">>> TxAgent has run_gradio_chat:", hasattr(TxAgent, "run_gradio_chat"))

# === Env vars
current_dir = os.path.dirname(os.path.abspath(__file__))
os.environ["MKL_THREADING_LAYER"] = "GNU"
os.environ["TOKENIZERS_PARALLELISM"] = "false"

# === UI Text
DESCRIPTION = '''
<div>
<h1 style="text-align: center;">TxAgent: An AI Agent for Therapeutic Reasoning Across a Universe of Tools</h1>
</div>
'''
INTRO = "Precision therapeutics require multimodal adaptive models..."
LICENSE = "DISCLAIMER: THIS WEBSITE DOES NOT PROVIDE MEDICAL ADVICE..."

css = """
h1 { text-align: center; }
.gradio-accordion { margin-top: 0 !important; margin-bottom: 0 !important; }
"""
chat_css = """
.gr-button { font-size: 18px !important; }
.gr-button svg { width: 26px !important; height: 26px !important; }
"""

# === Model setup
model_name = "mims-harvard/TxAgent-T1-Llama-3.1-8B"
rag_model_name = "mims-harvard/ToolRAG-T1-GTE-Qwen2-1.5B"
new_tool_files = {
    "new_tool": os.path.join(current_dir, "data", "new_tool.json")
}

# === Sample prompts
question_examples = [
    ["Given a 50-year-old patient experiencing severe acute pain and considering the use of the newly approved medication, Journavx, how should the dosage be adjusted considering moderate hepatic impairment?"],
    ["A 30-year-old patient is on Prozac for depression and now diagnosed with WHIM syndrome. Is Xolremdi suitable?"]
]

# === UI
def create_ui(agent):
    with gr.Blocks(css=css) as demo:
        gr.Markdown(DESCRIPTION)
        gr.Markdown(INTRO)

        temperature = gr.Slider(0, 1, step=0.1, value=0.3, label="Temperature")
        max_new_tokens = gr.Slider(128, 4096, step=1, value=1024, label="Max New Tokens")
        max_tokens = gr.Slider(128, 32000, step=1, value=8192, label="Max Total Tokens")
        max_round = gr.Slider(1, 50, step=1, value=30, label="Max Rounds")
        multi_agent = gr.Checkbox(label="Enable Multi-agent Reasoning", value=False)
        conversation_state = gr.State([])

        chatbot = gr.Chatbot(label="TxAgent", height=700, type="messages")
        message_input = gr.Textbox(placeholder="Ask a biomedical question...", show_label=False)

        send_btn = gr.Button("Send", variant="primary")

        # === Streaming handler
        def handle_chat(message, history, temperature, max_new_tokens, max_tokens, multi_agent, conversation, max_round):
            return agent.run_gradio_chat(
                message=message,
                history=history,
                temperature=temperature,
                max_new_tokens=max_new_tokens,
                max_token=max_tokens,
                call_agent=multi_agent,
                conversation=conversation,
                max_round=max_round
            )

        # === Submit handlers
        send_btn.click(
            fn=handle_chat,
            inputs=[message_input, chatbot, temperature, max_new_tokens, max_tokens, multi_agent, conversation_state, max_round],
            outputs=chatbot,
        )

        message_input.submit(
            fn=handle_chat,
            inputs=[message_input, chatbot, temperature, max_new_tokens, max_tokens, multi_agent, conversation_state, max_round],
            outputs=chatbot,
        )

        # === Example buttons
        gr.Examples(
            examples=question_examples,
            inputs=message_input
        )

        gr.Markdown(LICENSE)

    return demo

# === App start
if __name__ == "__main__":
    freeze_support()
    try:
        agent = TxAgent(
            model_name=model_name,
            rag_model_name=rag_model_name,
            tool_files_dict=new_tool_files,
            force_finish=True,
            enable_checker=True,
            step_rag_num=10,
            seed=100,
            additional_default_tools=["DirectResponse", "RequireClarification"]
        )
        agent.init_model()

        if not hasattr(agent, 'run_gradio_chat'):
            raise AttributeError("TxAgent is missing `run_gradio_chat`. Make sure the correct txagent.py is used.")

        demo = create_ui(agent)
        demo.launch(show_error=True)

    except Exception as e:
        print(f"🚨 App failed to start: {e}")
        raise