 I, Sekine Y, Ichijo H. Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis. J Biol Chem. 2015;290(17):10791–10803.
Minden A, Karin M. Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta. 1997;1333(2):F85–104.
González-Terán B, et al. p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration. EMBO J. 2016;35(5):536–552.
Kluwe J, et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology. 2010;138(1):347–359.
Nuño-Lámbarri N, Barbero-Becerra VJ, Uribe M, Chávez-Tapia NC. Mitochondrial Molecular Pathophysiology of Nonalcoholic Fatty Liver Disease: A Proteomics Approach. Int J Mol Sci. 2016;17(3):281.
Decaris ML, et al. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Hepatology. 2017;65(1):78–88.
Liles JT, et al. Combination of an ASK1 inhibitor and FXR agonist increases efficacy in a mouse model of non-alcoholic steatohepatitis. J Hepatol. 2017;66(1):S19–S20.
Bates J, et al. ACC inhibitor demonstrates potent anti-fibrotic activity in vitro and in vivo. J Hepatol. 2018;68:S399–S400.
Fujita M, et al. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001;280(1):L39–L49.
Former Massachusetts Gov. Mitt Romney has a message for GOP voters, and it comes without any sugarcoating.
"I think the Republican Party got lost," he said in an interview during a day of fundraising from Champaign to Chicago.
"I think we're seen as not being as fiscally conservative as we should have been. We're seen as spending too much and borrowing too much," Romney said Friday. "I think people expect us to be a very tightly managed party, and we did not demonstrate that. And I think people expect us to abide by the highest ethical standards."
As the race for the presidential nomination enters the furious fall stretch, Romney plans to "double down," as one adviser put it, on the notion that he is the answer that Republicans need to repair a political brand badly damaged after years of GOP governance.
His sharper tone appears to reflect a careful decision that he needs to start distancing himself more clearly from his party and its leadership in Congress, in an appeal to rank-and-file Republicans turned off by scandal and the GOP leadership in Washington.
It is unusual for a candidate to speak so bluntly about the performance of his party leaders in power. But with Democrats leading in enthusiasm and fundraising, Romney's newly honed rhetoric reflects the line he and other Republican hopefuls must walk between party loyalty and expressing the frustrations of so many activist Republicans.
The shift also may reflect the recent entry into the race of former Tennessee Sen. Fred Thompson, who is promoting himself, in part, as an old-fashioned, conservative Republican untainted by the mistakes of the current GOP regime.
Romney's push includes a new television commercial appearing in steady rotation in Iowa and New Hampshire in which he calls for Republicans to start acting like Republicans.
"We can't have ethical standards that are a punch line for Jay Leno," he says in the ad, a not-so-subtle reference to the plethora of scandals that have embarrassed the GOP, including Idaho Sen. Larry Craig's arrest in a bathroom sex-sting operation.
In a brief news conference in Chicago, Romney declined to identify those Republicans who have been ethically challenged. He said that in the "last 15 to 20 years in Washington, you have seen a pattern of people standing before microphones saying that everyone makes mistakes.... But we expect elected officials in the House, in the Senate and in the White House to abide by a higher ethical standard."
He also declined to say whether Craig, who was the Romney campaign's liaison to the Senate, should resign from office.
In an open letter to Republicans that will run as a full-page newspaper ad Sunday in New Hampshire's Manchester Union-Leader and Monday in Capitol Hill's Roll Call, Romney writes that Republicans can't be "Big Government Republicans," or "Washington Republicans." The party has to be about changing Washington, he says.
But first, writes Romney, "If we're going to change Washington, Republicans have to put our own house in order."
Yet he is skittish about getting specific about whose fault it is that federal spending has increased at a furious pace, that earmarks for pork-barrel projects mushroomed under Republican control of Congress and that the government's competence has been repeatedly called into question.
"I'm not going to characterize the management style of the president," Romney said in his interview with the Tribune. "He has great strengths, he's brought dignity and respect back to the White House, and he's kept us safe these last six years."
He added, "There are places where success has eluded him."
A prime example is the war in Iraq, a place where many candidates are looking to separate themselves from President Bush. Another is the federal response to Hurricane Katrina.
To be sure, Romney does not just reserve his slings for his own party. He is disparaging of the Democrats as he plays to the Republican base, which will determine the party's nominee.
"When Republicans act like Democrats, America loses," Romney says in both his ad and his letter, characterizing Democrats as even bigger spenders than Republicans and as poor stewards of the border.
Romney, whose conservative credentials have been questioned by those who recall his moderate Republican past and his Mormon religion, won praise Friday from Richard Viguerie, a longtime conservative political strategist.
Viguerie applauded Romney's distancing himself from the GOP under the leadership of Viguerie applauded Romney's distancing himself from the GOP under the leadership of Bush: "At last, a top-tier presidential candidate is paying attention to the discouraged, disheartened and disillusioned base of the Republican Party."
Tribune national correspondent Tim Jones contributed to this report.
"We can't be like Democrats – a party of big spending.
"We can't pretend our borders are secure from illegal immigration.

"When Republicans act like Democrats, America loses.
"It's time for Republicans to start acting like Republicans.
"It's time for a change and change begins with us.
"I'm Mitt Romney and I approve this message."Positive aspects and Down sides of Making use of A Sober Living Home For those individuals who're producing the tough changeover from institutionalized remedy back again to widespread modern society, thinking over the benefits and disadvantages of employing a sober living home is most likely the next stage. Though several physicians and therapists surely advise some sort of alcohol free living layout, it's not essential, but for many individuals, it can be a valuable stage together the strategy to greatest recovery. The solutions which are presented at 50 percent way homes are very comparable to that of therapy but simply because they permit you a great deal more freedom to live your everyday life, you have got the instant chance to take what that you are understanding and apply those to true life circumstances. Regardless of whether that you are profitable or not within your each day dealings, you can consider your encounters again to some stable and positive atmosphere exactly where your counselor, physician, or therapist can help you assess it. Of all of the benefits, by far the most optimistic activities that individuals explain is that you value the consistently supportive atmosphere. One of the toughest parts of dealing with the changeover into popular culture is when once again dealing with the challenges of one's life, usually by itself. Help teams can just offer aid through the occasions they meet whilst other remedy possibilities can price drastically way more money. Coming back directly for your home existence, although, is usually relatively difficult as folks out of your past might possibly attempt to treat you as outlined by the way in which you made use of to be, and not according to the particular person you happen to be attempting to turn out to be. This can not simply be pretty irritating for them, nevertheless it is often quite complicated for you personally as that you are attempting to set up your brand-new id. When taking a look at a halfway home, you ought to look into that depending on your definition, a sober living property is deemed a type of healthcare remedy and it is for that reason generally covered by healthcare insurance. A lot of folks who arrive out of treatment face the cruel reality that they've to immediately get operate and begin residing some thing that looks like a typical existence. By transitioning right into a 50 percent way property, even though, you can actually start assimilating your self into culture once more and relieve your way back again into regular work due to the fact your insurance will deal with, no less than, a bulk of your residing costs. Of all the elements of residing in halfway houses, one of the most unpleasant element is that it still seems like therapy. You happen to be often needed to obey a curfew and adhere to residence