 by a small manufacturer near Stuttgart in the mid-'60s, which Paul Lemp favours as DI boxes for "unbalanced and boring” signals, as he puts it. There are some transistor-based units, including a few Siemens Sitral modules, but Ingo Krauss usually prefers valve equipment: "When I put a vocal through a valve mic, valve preamp and a valve compressor I slowly begin to feel comfortable,” he says.
Speaking of microphones, Candy Bomber's lockers hold Neumann classics such as several U67s, M149s and M150s, ribbon mics from Beyer, Coles and Electro-Voice, and a vintage Rohde & Schwarz EZGN measurement microphone that Paul Lemp loves as a room mic. With EMT reverb plates and an AKG BX20 spring reverb, Candy Bomber is well equipped in this area too, and there are also a few classic tape recorders, the most notable probably being a four-track, one-inch, all-valve Telefunken T9c, amongst other Telefunken and Studer machines.
Recent clients include German acts such as Tocotronic, Beatsteaks, Die Ärzte, Caspar Brötzmann and Jochen Arbeit (Einstürzende Neubauten), but also international artists such as the Stooges, Gemma Ray, Anton Sword and Larry Mullins/Toby Dammit. All are attracted by Candy Bomber's unique setup and environment, which truly bridges the gap between the past and the present.
PARP inhibitors (PARPi), such as Olaparib, have shown promising results in high-grade serous (HGS) epithelial ovarian cancer (EOC) treatment. PARPi sensitivity has been mainly associated with homologous recombination (HR) deficiency, but clinical trials have shown that predicting actual patient response is complex. Here, we investigated gene expression microarray, HR functionality and Olaparib sensitivity of 18 different HGS EOC cell lines and demonstrate that PARPi sensitivity is not only associated with HR defects. Gene target validation show that down regulation of genes in the nucleotide excision repair (NER) and mismatch repair (MMR) pathways (ERCC8 and MLH1, respectively) increases PARPi response. The highest sensitivity was observed when genes in both the HR and either NER or MMR pathways were concomitantly down regulated. Using clinical samples, patients with these concurrent down regulations could be identified. Based on these results, a novel model to predict PARPi sensitivity is herein proposed. This model implies that the extreme responders identified in clinical trials have deficiencies in HR and either NER or MMR.Chrissy Teigen is apologizing for her past bullying and "awful" behavior on social media. Last month, after TV personality Courtney Stodden opened up about being bullied by the cookbook author when they were younger, Chrissy issued an apology on Twitter and subsequently took a break from her accounts. On Monday, in a lengthy statement published to Medium and shared on her Instagram, she admitted to "being a troll" and expressed deep regret for her actions. "I want you to know I've been sitting in a hole of deserved global punishment, the ultimate'sit here and think about what you've done'," she wrote. "Not a day, not a single moment has passed where I haven't felt the crushing weight of regret for the things I've said in the past."
"There is simply no excuse for my past horrible tweets."
Chrissy went on to share she's in the process of privately apologizing to others she insulted on social media, aside from Courtney. "There is simply no excuse for my past horrible tweets," she wrote. "My targets didn't deserve them. No one does. Many of them needed empathy, kindness, understanding and support, not my meanness masquerading as a kind of casual, edgy humor." Shortly after Chrissy shared her apology, fashion designer Michael Costello alleged that he was bullied by Chrissy and that she tried to ruin his career.
While she initially "had so much fun" when she first started using social media, snarking at celebrities, leading to her rise in Twitter fame, she admitted that in reality, she was immature and insecure, and thought she needed to "impress strangers to be accepted." She wrote: "If there was a pop culture pile-on, I took to Twitter to try to gain attention and show off what I at the time believed was a crude, clever, harmless quip. I thought it made me cool and relatable if I poked fun at celebrities."
The cookbook author said she's no longer the person who wrote "those horrible things," and that she's grown up, gotten married, had kids, and gotten a lot of therapy along the way. Chrissy ended her apology by asking fans not for forgiveness, but for the opportunity to own her past mistakes and "seek self improvement and change," writing, "We are all more than our worst moments." Read her full statement below.
Multigenerational Living in Paradisecomments (1) December 24th, 2010 in Blogs
Bali has every shade of green on earth, soft air scented with jasmine and a landscape pulsing with slender, good-looking people in constant motion. That kinetic energy is most apparent in the towns but anywhere you travel on the island’s snaky, two-lane mountain roads it’s common to see families of four or five on a single motorcycle, arms and legs akimbo, threading their way among flatbed trucks loaded to the gunnels with bricks and bags of cement, farmers balanced on bicycles half-buried beneath bundles of thatch-grass, and knots of scruffy dun-colored dogs somehow not getting run over. The traffic made me white-knuckled but the Balinese navigated it gracefully, as if choreographed, with nary an unpleasant word or angry gesture. When traffic gets really scary, a belief in reincarnation probably comes in handy, too.
To be honest, I found the lack of road rage a little unsettling because I had no explanation for it. But after meeting that same easy-going spirit over and over—even when haggling in the market—I began to think that maybe these folks really were a different kind of human. With dazzling smiles. Surely they have their cares, 2.8 meter x 3.5.
Given that awareness of the interconnectedness of life, perhaps it was only natural that when Legut and Billye met and became fast friends, that Legut should help Billye find land near his banjar and help build her home and shortly after that--when he and Santi married and began raising a family--that all of them should live under the same roof. Do not all of us, after all, dwell under the same sky?
--
PS This trip took place two years ago, in 2008, and it was the first time I'd been off the North American land mass in three decades. Thanks to airlines' penchant for routing your flight all over creation when you cash in frequent-flier miles, the flight took 29 hours, with an 8-hour layover in Beijing, so I was punch-drunk with jet lag for quite a while. Finding an in-law-unit story in Bali was a complete delight, however, because I had just begun the research that lead to my writing a book on the subject, which will be published in March, 2011, by Taunton Press. The Bali tale is not in the book but 30 case histories in the U.S. and Canada are. If the topic interests you, please check out the book's write-up at the Taunton Store:
or for a sample of the book's photos, please visit my website:
© Michael Litchfield 2010
posted in: Blogs, in-law units, accessory dwelling units, multi-generational living
How to Paint Fiber-Cement Siding
Painter Jim Lacey shares some tips for caulking and painting fiber-cement siding.
Posted: 9:09 pm on December 28th
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package pl.poznan.put.structure.formats;

import org.immutables.value.Value;
import pl.poznan.put.structure.DotBracketSymbol;

import java.util.List;

/** A colecction of missing dot-bracket symbols at 5' or 3' end. */
@Value.Immutable
public abstract class TerminalMissing {
  /** @return The list of missing symbols. */
  @Value.Parameter(order = 1)
  public abstract List<DotBracketSymbol> symbols();
}
SESAR JU partners demonstrated the effectiveness of a system using plate lines – parallel plates arranged one after another - to reduce wake vortices at large airports.
High up in the air, wake vortices usually descend quickly, drift away and finally dissipate. Near the ground, they can hover for some time, a short distance upstream of the runway threshold. This is exactly where subsequent aircraft finish their approach. A system of plates arranged in parallel one behind the other, referred to as a plate line, can be set up to attenuate the circulating vortices in front of a runway more quickly. Secondary vortices form on the plates, which are about nine metres long and 4.5 metres high in this test installation. This causes the wake vortices to decay much more quickly.
Location: Located in Srirampura, Lingabudi Lake is