: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Phosphodiesterase type 5 (PDE5) inhibitors with improved PDE isozyme selectivity relative to sildenafil may result in agents for the treatment of male erectile dysfunction (MED) with a lower incidence of PDE-associated adverse effects. This paper describes the discovery of 14, a PDE5 inhibitor with improved potency and selectivity in vitro compared to sildenafil. This compound shows activity in a functional assay of erectile function comparable to that of sildenafil.<gh_stars>0
package com.school.service;

import com.school.exception.SchoolException;
import com.school.message.request.LoginForm;
import com.school.message.response.JwtResponse;
import com.school.message.response.JwtUserResponse;

public interface ILoginService {
	public JwtUserResponse getJwtByLogin(LoginForm loginRequest) throws SchoolException;
}
My resolution to this issue was to leave the judgements to God and trust Him.  He’s perfect, inscrutable, all loving, and good.

The trap the demons lead people into on this issue is to tempt them to judge God Himself, by saying, “God is not loving if He doesn’t save all.”

Who are we to judge the Holy Trinity?!  Lord have mercy.  I cannot think of a more demonic temptation.  

Rather trust in Him because He is trustworthy and worry about your own repentance and pray for others, including the dead.  God will handle the rest.  ☦️Please provide your recommendations for backing up Windows VMs on networks with limited upload bandwidth and/or a minimal backup window. Windows server backup captures data files to USB drives but I want to backup the VMs from the hyper-v host to a local resource. Using a $10k + appliance is out of the question.
OK, so what is your budget for this? Some of this becomes a management decision, because it involves budgets. Your first goal is to clearly communicate what you're doing now and what the risks associated with it are.
How much data do you have to back up? Ideally, you follow the link above.
3. On Prem storage that sends data to the cloud?
There are TONS of solutions depending on your needs.
Off hand I would recommend a solution that offers incremental backups that are Application aware (depending on the servers that you are looking to backup). What types of restoration you are looking to achieve then would dictate your solution more.
You say limited bandwidth but you say on premise?
How much raw data is being backed up? Depending on the solution, the money goes to cloud storage, maint, support, etc than local storage. Local storage is cheap.
Need some answers before your gonna get much help.
- What is the budget? Saying that a $10k+ appliance is out of the question doesn't help much. What are you looking to spend and what does that $ need to buy? Backup software? Storage for backups?
Veeam is a great backup software. They have the essentials licensing for small environments.
As far as the storage, you could get a NAS like a Synology Rackstation for a couple of grand, but you may consider doing a separate server, with enough local storage.
A HPE ProLiant DL380G9 with enough local storage and Server 2012R2 (or 2016). The built in deduplication in server 2012r2 and above is pretty powerful. My backup storage server has 20TB of useable space, my backups are currently taking up 12TB, but with the deduplication I am able to store about 70TB worth of backup data on that system. I also use a LTO-6 drive for monthly offsite backup storage.
Thank you all for your replies. I (we) have been in this long enough to have evolved from floppies, to TapeWare, ArcServe, BackupExec, Windows Server Backup, Xcopy, Remote Backup and Microsoft Azure Backup. We're serving tiny businesses, not small businesses. Companies with a server or three, generally a Microsoft hyper-v controller and a guest VM or two. Data storage is typically less than 2T.
At this time we try to use a USB backup for guest VM data but really want to backup those VHDX files as an additional layer of protection. But, the size of those files typically precludes backing them up to remote resources as we generally have only six hours or so to push the data and have no clients with more that a 10 Mbps upload capacity.
I haven't asked for a project budget on this because we haven't settled on the best practice.By Roomana Hukil
19 November 2014
On 4 November 2014, a young Christian couple was publically set on fire in Punjab, Pakistan. It was alleged by a mob of 1200 persons that the couple had desecrated verses from the Quran. According to source, the mob had apparently offered a waiving of severe retribution if the couple converted to Islam, but when the couple refused, locked them in a brick kiln, and set on fire.
Harassment and instances of violence against Pakistan’s minority Christian community has increased suddenly in the past few years. Last year, anti-Christian riots erupted in Gojra and Lahore, causing 170 families to flee their homes.
According to the Human Rights Commission of Pakistan, in 2013, 501 people were victimised on blasphemy charges that entailed incidents categorised under “attacks on places of worship, stating derogatory remarks, disgracing in any form, unclear happenings and other cases.” While most outbreaks are instigated out of socio-economic reasons, they are constantly also backed by religious dogmas and false accusations of blasphemy. In the recent years, this trend has become increasingly pronounced. Assassinations of high-profile political leaders, attacks on the impoverished populations, and expulsions of minority students for misspelling/ misquoting the Quran point towards the intensification of radicalism and resultant attitudes among hard-line Islamists in Pakistan.
Why are Christians being targeted in Pakistan? Why is the Pakistani State reluctant to re-evaluate or repeal the biased blasphemy laws?
Vulnerability
Christians are the second-largest religious minority in Pakistan after the Hindus, representing 1.8 per cent of the country's total population. A large number of Christians reside in south Karachi, Punjab and Khyber Pakhtunkhwa. While a section resides in the poorest sectors of Pakistan involved menial jobs, there is a significant section that is flourishing in the corporate sector, in Karachi. In Pakistan, any sense of economic progression or identity-assertion by a minority group results in a sense of paranoia among the radicals in the majority groups. Consequently, both sides, irrespective of their economic contribution to the country are vulnerable to the wrath of Islamist extremism in Pakistan.
Additionally, there has been a gradual change shift in the Christian community vis-à-vis their socio-economic and political demands. Since 1992, the Pakistan Christian Congress (PCC) has been demanding a separate Christian province in Punjab. Furthermore, Christians have been extremely vocal in expressing equal rights, demanding state benefits, exhibiting intolerance towards the blasphemy laws and refuting the majoritarian attitude towards the minority groups. Asserting for greater autonomy and representation in society is largely dismissed in Pakistan. Minority communities that remain submissive and camouflage within the rest of the society are accepted by the radicals. Those who resist are assaulted.
For instance, the Pakistani Federal Minister for Minority Affairs, Shahbaz Bhatti, was assassinated on the grounds of supporting the cause of Pakistani Christians, condemning the 2009 Gojra riots and demanding for justice.
Role of Blasphemy Laws
Section 295-C of the Pakistan Penal Code was introduced during the 1980s. It reinstated the position of religious zealots to act according to their whims and fancies. Pakistan has some of the strictest anti-blasphemy laws in the world, and they prescribe punitive punishment to those who ‘deliberately intend to wound the religious sentiments of others in their sight, hearing, and presence through imprisonment, fine or both’.
The law has been heavily criticised for extending protection towards the embodiments of the Islamic faith alone while excluding that of other religious faiths. While the law is applicable to all, in a multi-faith society such as Pakistan, it is seen as highly discriminatory, as even the slightest rumours about instances of defaming the Prophet and/or the Quran continues to spark hysteria amongst the radicalised Muslims.
Stagnant Status Quo
The state has condemned violent attacks against the Christian community, but its tight-lipped stance on the issue of amendment or repealing of the biased laws questions the government’s credibility and intents on the issue. Given the identity of the country as an Islamic Republic, the government feels that any move towards altering the blasphemy laws will infuriate religious extremists who might reciprocate in unfavourable ways. In 2011, the former Governor of Punjab, Salman Taseer, was assassinated for criticising the blasphemy law while advocating for justice for Asia Bibi – a Christian woman who was sentenced to death over allegations of defaming the Prophet. The then government that had initially announced its intention to amend the law fell silent on the subject after Taseer’s assassination.
Repealing the law doesn’t alone or automatically mean the end of the woes of the Christian community. While it may bring about a change