 to small business owners and entrepreneurs, says Anna.
At the end of the week I have to do a recon to check things like refunds and to work out salaries for staff. The sales history on the app is great for listing all the transactions, but when I need to do my books it’s not really that useful and I have to do this manually. Doing this on my mobile phone late on a Sunday makes it a pain. I feel like I can’t get any down time between my business and my business admin.
By valuing her time and managing how she works in order to be mentally and physically at her best, Anna has been able to make things happen, and this is how I Heart Market came to being.
During her rest interim, she travelled to Cape Town and witnessed the successful, vibrant market scene there. “I came back to Durban and thought we really need to do something like that here,” Anna remembers. With the market being a once a month event, she could manage her chronic fatigue and look into getting the market started, with the vision of creating a platform for edgy crafters and makers.
The first market was outside Bean Bag Bohemia, on the pavement of Windemere Road. Each month more traders came, and so a bigger space was needed. From Bean Bag to St. Mary’s Church Hall, to the D.L.I Hall. Moses Mabhida, which has been the main station for the market until July 2019, approached Anna and her team and asked them to set up shop.
Whilst the market was going, she ran a number of businesses. She started Unit 11 with friends, a beloved space that remains in the collective memory of live music aficionados of the 2010 – 2012 period. The Plant, Station Drive, The Morning Trade and those I heart Durban parties, are a few other spaces she has left her mark. The market, however, has been her main gig, and the unpredictable nature of it intrigues her.
“There is an ebb and flow that you can’t control,” Anna tells me. She explains that it becomes exciting each month as new traders are brought in and new marketing strategies are tried.
Pela Pela Foods - Yoco Merchant #30 952.
A fun day out for the family in the grounds outside Kings Park stadium.
Duduzile Ngubane of Du Confidence with her designs.
With her chef experience and chronic fatigue, the two parts of her life would marry well, and we could get to sample her herbal creations at the next market? For now, much like Anna, the Market is changing, with new partnerships (including with Yoco) and possibly a new venue. The recent change is what keeps Anna on her toes, and what makes her a savvy business person. Look out for a new market experience, unlike the one we all know, as I Heart Market and Anna Savage level things up.
I haven't the time nor enough skin on my thumbs to respond to every point you've made here. But I just wanna say, your take on post "death" skill soaked Fitz was brilliant. 

Motherfucking Fitzchivalry Farseer. Is my favourite sentence for this week. 

Also, I found the ending to be really happy personally. From the moment that dart touched Fitz I knew it, he was dead, Hobb wasn't letting him survive. It was his time. I have no idea how my life will end. But if it ends half as well as Fitz's did, I'll go out happy. (Minus coughing up flesh devouring parasites, I guess)Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity.

Previous studies suggest that activation of SIRT1 protects liver from acetaminophen (APAP)-induced injury; however, the detailed mechanism of SIRT1 modulation in this process is still incomplete. Therefore, this study was to investigate the pathophysiological role of SIRT1 in APAP-mediated hepatotoxicity. We found that SIRT1 mRNA and protein were markedly upregulated in human LO2 cells and mouse liver upon APAP exposure. In vitro, the specific knockdown of SIRT1 expression ultimately aggravated APAP-evoked cellular antioxidant defense in LO2 cells. Moreover, lentivirus-mediated knockdown of hepatic SIRT1 expression exacerbated APAP-induced oxidative stress and liver injury, especially reduction of Nrf2 and subsequent downregulation of several antioxidant genes. Intriguingly, 30 mg/kg SRT1720, the specific SIRT1 activator, which greatly enhanced Nrf2 expression and antioxidant defense, and then eventually reversed APAP-induced hepatic liver injury in mice. Furthermore, APAP responsive miR-19b played an important role in regulating SIRT1 expression, whereas overexpression miR-19b largely abolished the induction of SIRT1 by APAP in vitro and in vivo. Specific SIRT1 3'-UTR mutation, which disrupted the interaction of miRNA-3'UTR, and successfully abrogated the modulation by miR-19b. Notably, hepatic miR-19b overexpression worsened the APAP-induced hepatotoxicity. In general, our results support the notion that the strong elevation of SIRT1 by APAP responsive miR-19b may represent a compensatory mechanism to protect liver against the drug-induced damage, at least in part by enhancing Nrf2-mediated antioxidant capacity in the liver.We report an inexpensive, high-throughput method for isolating DNA from insect and plant samples for the purpose of detecting Xylella fastidiosa infection. Existing methods often copurify inhibitors of DNA polymerases, limiting their usefulness for PCR-based detection assays. When compared to commercially available kits, the method provides enhanced pathogen detection at a fraction of the cost.
Brady, J. A., Faske, J. B., Castañeda-Gill, J. M., King, J. L., & Mitchell, F. L.
Mobile Ranks High in Top 10 Business Opportunities List
SwiftKey is a great example of a money-spinning appMobile apps and smartphone repairs have been named as two of the top 10 business opportunities for entrepreneurs in 2012, according to a new report from Startups.co.uk, the online resource for entrepreneurs.
The report, entitled What Business to Start in 2012, pinpoints the 10 specific business openings which offer the greatest potential for the year ahead. It is the product of two months of research, which involved analysing market trends and data, and interviews with industry experts, prominent investors, business and thought leaders, and entrepreneurs.
Apps come in at No.5 in the list, with smartphone repairs close behind at No.6. Frozen yoghurt heads the list, with annual UK sales currently standing at around £4m, and forecast to soar to £150m by 2013. Independent coffee shops is at No.2, with hobby and crafts at No.3, and social gaming at No.4. Places 7 – 10 in the list are occupied by, respectively, the Olympics; cycling; careers advice; and dance & fitness.
“During our research we uncovered dozens of fascinating business opportunities, and it was extremely difficult to drill down to a final 10,” says Startups.co.uk editor, Steph Welstead. “We also unearthed some fantastic entrepreneurs who are already capitalising on these opportunities…However, it’s important to stress that starting up in one of these sectors is by no means a guarantee of success. Starting a business is a huge commitment and there are no golden tickets. With any business, you need the right business model, pricing, location, people and attitude to make it work. That said, we hope our report will provide much inspiration for anyone thinking about becoming an entrepreneur in 2012.”
According to recent research from Creditsafe, the number of new businesses launched in the UK in 2011 was almost 20 per cent higher than 2010, and early indications show this rise looks set to continue in 2012.
- News:We have three Teach Your Monster to Read kids T-shirts to giveaway. All you need to do is name our cute new game 3 character, The Dragon.
The best answer (as judged by some of our young players) will be sent one of our T-shirts (size 5 years). Just put your suggestions in the comment box below.
Here’s a couple of our monster fans wearing the T-shirts.
Don’t forget! Teach Your Monster to Read 3: Champion Reader launches on 4th June 2015.
The deadline for the competition is 1st June 2015. Terms and Conditions can be found here.
Champion Reader launches on 4th June 2015.
Jessica is a very wise woman. She is purple and sparkly and has luscious long white hair topped of with a starry hat. Wow, she’s magical!
Luckily Jessica is the monster’s friend and guide in this new adventure. She helps the monster through the maze-like planets, advising it which direction to go and providing hints about what it should do next.
Jessica also keeps a careful eye out for danger. She warns the monster when the pesky Goblin Prince is about to appear and helps the monster to catch him. Listen to Jessica, she is very smart.
Defeat the dragon in Champion Reader!
The dragon is a funny and fiery new addition to Teach Your Monster to Read. He’s blue and scaly and rocks back and forth on a spring! Watch out, though, because he breathes out fiery words which the monster must read and understand.
In order to defeat the dragon the monsters must find the correct sound in the words.
This is a great game for rehearsing the different ways of spelling the phon