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Mar 14

EasyNER: A Customizable Easy-to-Use Pipeline for Deep Learning- and Dictionary-based Named Entity Recognition from Medical Text

Medical research generates a large number of publications with the PubMed database already containing >35 million research articles. Integration of the knowledge scattered across this large body of literature could provide key insights into physiological mechanisms and disease processes leading to novel medical interventions. However, it is a great challenge for researchers to utilize this information in full since the scale and complexity of the data greatly surpasses human processing abilities. This becomes especially problematic in cases of extreme urgency like the COVID-19 pandemic. Automated text mining can help extract and connect information from the large body of medical research articles. The first step in text mining is typically the identification of specific classes of keywords (e.g., all protein or disease names), so called Named Entity Recognition (NER). Here we present an end-to-end pipeline for NER of typical entities found in medical research articles, including diseases, cells, chemicals, genes/proteins, and species. The pipeline can access and process large medical research article collections (PubMed, CORD-19) or raw text and incorporates a series of deep learning models fine-tuned on the HUNER corpora collection. In addition, the pipeline can perform dictionary-based NER related to COVID-19 and other medical topics. Users can also load their own NER models and dictionaries to include additional entities. The output consists of publication-ready ranked lists and graphs of detected entities and files containing the annotated texts. An associated script allows rapid inspection of the results for specific entities of interest. As model use cases, the pipeline was deployed on two collections of autophagy-related abstracts from PubMed and on the CORD19 dataset, a collection of 764 398 research article abstracts related to COVID-19.

TransliCo: A Contrastive Learning Framework to Address the Script Barrier in Multilingual Pretrained Language Models

The world's more than 7000 languages are written in at least 293 scripts. Due to various reasons, many closely related languages use different scripts, which poses a difficulty for multilingual pretrained language models (mPLMs) in learning crosslingual knowledge through lexical overlap. As a consequence, mPLMs are faced with a script barrier: representations from different scripts are located in different subspaces, which can result in crosslingual transfer involving languages of different scripts performing suboptimally. To address this problem, we propose TransliCo, a framework that optimizes the Transliteration Contrastive Modeling (TCM) objective to fine-tune an mPLM by contrasting sentences in its training data and their transliterations in a unified script (in our case Latin), which enhances uniformity in the representation space for different scripts. Using Glot500-m, an mPLM pretrained on over 500 languages, as our source model, we fine-tune it on a small portion (5%) of its training data, and refer to the resulting model as Furina. We show that Furina not only better aligns representations from distinct scripts but also outperforms the original Glot500-m on various zero-shot crosslingual transfer tasks. Additionally, we achieve consistent improvement in a case study on the Indic group where the languages exhibit areal features but use different scripts. We make our code and models publicly available.

"Kurosawa": A Script Writer's Assistant

Storytelling is the lifeline of the entertainment industry -- movies, TV shows, and stand-up comedies, all need stories. A good and gripping script is the lifeline of storytelling and demands creativity and resource investment. Good scriptwriters are rare to find and often work under severe time pressure. Consequently, entertainment media are actively looking for automation. In this paper, we present an AI-based script-writing workbench called KUROSAWA which addresses the tasks of plot generation and script generation. Plot generation aims to generate a coherent and creative plot (600-800 words) given a prompt (15-40 words). Script generation, on the other hand, generates a scene (200-500 words) in a screenplay format from a brief description (15-40 words). Kurosawa needs data to train. We use a 4-act structure of storytelling to annotate the plot dataset manually. We create a dataset of 1000 manually annotated plots and their corresponding prompts/storylines and a gold-standard dataset of 1000 scenes with four main elements -- scene headings, action lines, dialogues, and character names -- tagged individually. We fine-tune GPT-3 with the above datasets to generate plots and scenes. These plots and scenes are first evaluated and then used by the scriptwriters of a large and famous media platform ErosNow. We release the annotated datasets and the models trained on these datasets as a working benchmark for automatic movie plot and script generation.

BEACON: Benchmark for Comprehensive RNA Tasks and Language Models

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms. Despite the emergence of numerous deep learning approaches for RNA, particularly universal RNA language models, there remains a significant lack of standardized benchmarks to assess the effectiveness of these methods. In this study, we introduce the first comprehensive RNA benchmark BEACON (BEnchmArk for COmprehensive RNA Task and Language Models). First, BEACON comprises 13 distinct tasks derived from extensive previous work covering structural analysis, functional studies, and engineering applications, enabling a comprehensive assessment of the performance of methods on various RNA understanding tasks. Second, we examine a range of models, including traditional approaches like CNNs, as well as advanced RNA foundation models based on language models, offering valuable insights into the task-specific performances of these models. Third, we investigate the vital RNA language model components from the tokenizer and positional encoding aspects. Notably, our findings emphasize the superiority of single nucleotide tokenization and the effectiveness of Attention with Linear Biases (ALiBi) over traditional positional encoding methods. Based on these insights, a simple yet strong baseline called BEACON-B is proposed, which can achieve outstanding performance with limited data and computational resources. The datasets and source code of our benchmark are available at https://github.com/terry-r123/RNABenchmark.

Intent-based Prompt Calibration: Enhancing prompt optimization with synthetic boundary cases

Prompt engineering is a challenging and important task due to the high sensitivity of Large Language Models (LLMs) to the given prompt and the inherent ambiguity of a textual task instruction. Automatic prompt engineering is essential to achieve optimized performance from LLMs. Recent studies have demonstrated the capabilities of LLMs to automatically conduct prompt engineering by employing a meta-prompt that incorporates the outcomes of the last trials and proposes an improved prompt. However, this requires a high-quality benchmark to compare different prompts, which is difficult and expensive to acquire in many real-world use cases. In this work, we introduce a new method for automatic prompt engineering, using a calibration process that iteratively refines the prompt to the user intent. During the optimization process, the system jointly generates synthetic data of boundary use cases and optimizes the prompt according to the generated dataset. We demonstrate the effectiveness of our method with respect to strong proprietary models on real-world tasks such as moderation and generation. Our method outperforms state-of-the-art methods with a limited number of annotated samples. Furthermore, we validate the advantages of each one of the system's key components. Our system is built in a modular way, facilitating easy adaptation to other tasks. The code is available https://github.com/Eladlev/AutoPrompt{here}.

LangSAMP: Language-Script Aware Multilingual Pretraining

Recent multilingual pretrained language models (mPLMs) often avoid using language embeddings -- learnable vectors assigned to different languages. These embeddings are discarded for two main reasons: (1) mPLMs are expected to have a single, unified parameter set across all languages, and (2) they need to function seamlessly as universal text encoders without requiring language IDs as input. However, this removal increases the burden on token embeddings to encode all language-specific information, which may hinder the model's ability to produce more language-neutral representations. To address this challenge, we propose Language-Script Aware Multilingual Pretraining (LangSAMP), a method that incorporates both language and script embeddings to enhance representation learning while maintaining a simple architecture. Specifically, we integrate these embeddings into the output of the transformer blocks before passing the final representations to the language modeling head for prediction. We apply LangSAMP to the continual pretraining of XLM-R on a highly multilingual corpus covering more than 500 languages. The resulting model consistently outperforms the baseline. Extensive analysis further shows that language/script embeddings encode language/script-specific information, which improves the selection of source languages for crosslingual transfer. We make our code and models publicly available at https://github.com/cisnlp/LangSAMP.

Leveraging Broadcast Media Subtitle Transcripts for Automatic Speech Recognition and Subtitling

The recent advancement of speech recognition technology has been driven by large-scale datasets and attention-based architectures, but many challenges still remain, especially for low-resource languages and dialects. This paper explores the integration of weakly supervised transcripts from TV subtitles into automatic speech recognition (ASR) systems, aiming to improve both verbatim transcriptions and automatically generated subtitles. To this end, verbatim data and subtitles are regarded as different domains or languages, due to their distinct characteristics. We propose and compare several end-to-end architectures that are designed to jointly model both modalities with separate or shared encoders and decoders. The proposed methods are able to jointly generate a verbatim transcription and a subtitle. Evaluation on Flemish (Belgian Dutch) demonstrates that a model with cascaded encoders and separate decoders allows to represent the differences between the two data types most efficiently while improving on both domains. Despite differences in domain and linguistic variations, combining verbatim transcripts with subtitle data leads to notable ASR improvements without the need for extensive preprocessing. Additionally, experiments with a large-scale subtitle dataset show the scalability of the proposed approach. The methods not only improve ASR accuracy but also generate subtitles that closely match standard written text, offering several potential applications.

A Multi-Modal AI Copilot for Single-Cell Analysis with Instruction Following

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular biology", capturing intricate gene expression patterns at the single-cell level. However, interacting with this "language" through conventional tools is often inefficient and unintuitive, posing challenges for researchers. To address these limitations, we present InstructCell, a multi-modal AI copilot that leverages natural language as a medium for more direct and flexible single-cell analysis. We construct a comprehensive multi-modal instruction dataset that pairs text-based instructions with scRNA-seq profiles from diverse tissues and species. Building on this, we develop a multi-modal cell language architecture capable of simultaneously interpreting and processing both modalities. InstructCell empowers researchers to accomplish critical tasks-such as cell type annotation, conditional pseudo-cell generation, and drug sensitivity prediction-using straightforward natural language commands. Extensive evaluations demonstrate that InstructCell consistently meets or exceeds the performance of existing single-cell foundation models, while adapting to diverse experimental conditions. More importantly, InstructCell provides an accessible and intuitive tool for exploring complex single-cell data, lowering technical barriers and enabling deeper biological insights.

Sequence-to-Action: Grammatical Error Correction with Action Guided Sequence Generation

The task of Grammatical Error Correction (GEC) has received remarkable attention with wide applications in Natural Language Processing (NLP) in recent years. While one of the key principles of GEC is to keep the correct parts unchanged and avoid over-correction, previous sequence-to-sequence (seq2seq) models generate results from scratch, which are not guaranteed to follow the original sentence structure and may suffer from the over-correction problem. In the meantime, the recently proposed sequence tagging models can overcome the over-correction problem by only generating edit operations, but are conditioned on human designed language-specific tagging labels. In this paper, we combine the pros and alleviate the cons of both models by proposing a novel Sequence-to-Action~(S2A) module. The S2A module jointly takes the source and target sentences as input, and is able to automatically generate a token-level action sequence before predicting each token, where each action is generated from three choices named SKIP, COPY and GENerate. Then the actions are fused with the basic seq2seq framework to provide final predictions. We conduct experiments on the benchmark datasets of both English and Chinese GEC tasks. Our model consistently outperforms the seq2seq baselines, while being able to significantly alleviate the over-correction problem as well as holding better generality and diversity in the generation results compared to the sequence tagging models.

MAMMAL -- Molecular Aligned Multi-Modal Architecture and Language

Drug discovery typically consists of multiple steps, including identifying a target protein key to a disease's etiology, validating that interacting with this target could prevent symptoms or cure the disease, discovering a small molecule or biologic therapeutic to interact with it, and optimizing the candidate molecule through a complex landscape of required properties. Drug discovery related tasks often involve prediction and generation while considering multiple entities that potentially interact, which poses a challenge for typical AI models. For this purpose we present MAMMAL - Molecular Aligned Multi-Modal Architecture and Language - a method that we applied to create a versatile multi-task foundation model ibm/biomed.omics.bl.sm.ma-ted-458m that learns from large-scale biological datasets (2 billion samples) across diverse modalities, including proteins, small molecules, and genes. We introduce a prompt syntax that supports a wide range of classification, regression, and generation tasks. It allows combining different modalities and entity types as inputs and/or outputs. Our model handles combinations of tokens and scalars and enables the generation of small molecules and proteins, property prediction, and transcriptomic lab test predictions. We evaluated the model on 11 diverse downstream tasks spanning different steps within a typical drug discovery pipeline, where it reaches new SOTA in 9 tasks and is comparable to SOTA in 2 tasks. This performance is achieved while using a unified architecture serving all tasks, in contrast to the original SOTA performance achieved using tailored architectures. The model code and pretrained weights are publicly available at https://github.com/BiomedSciAI/biomed-multi-alignment and https://huggingface.co/ibm/biomed.omics.bl.sm.ma-ted-458m.

LivelySpeaker: Towards Semantic-Aware Co-Speech Gesture Generation

Gestures are non-verbal but important behaviors accompanying people's speech. While previous methods are able to generate speech rhythm-synchronized gestures, the semantic context of the speech is generally lacking in the gesticulations. Although semantic gestures do not occur very regularly in human speech, they are indeed the key for the audience to understand the speech context in a more immersive environment. Hence, we introduce LivelySpeaker, a framework that realizes semantics-aware co-speech gesture generation and offers several control handles. In particular, our method decouples the task into two stages: script-based gesture generation and audio-guided rhythm refinement. Specifically, the script-based gesture generation leverages the pre-trained CLIP text embeddings as the guidance for generating gestures that are highly semantically aligned with the script. Then, we devise a simple but effective diffusion-based gesture generation backbone simply using pure MLPs, that is conditioned on only audio signals and learns to gesticulate with realistic motions. We utilize such powerful prior to rhyme the script-guided gestures with the audio signals, notably in a zero-shot setting. Our novel two-stage generation framework also enables several applications, such as changing the gesticulation style, editing the co-speech gestures via textual prompting, and controlling the semantic awareness and rhythm alignment with guided diffusion. Extensive experiments demonstrate the advantages of the proposed framework over competing methods. In addition, our core diffusion-based generative model also achieves state-of-the-art performance on two benchmarks. The code and model will be released to facilitate future research.

Layout and Task Aware Instruction Prompt for Zero-shot Document Image Question Answering

Layout-aware pre-trained models has achieved significant progress on document image question answering. They introduce extra learnable modules into existing language models to capture layout information within document images from text bounding box coordinates obtained by OCR tools. However, extra modules necessitate pre-training on extensive document images. This prevents these methods from directly utilizing off-the-shelf instruction-tuning language foundation models, which have recently shown promising potential in zero-shot learning. Instead, in this paper, we find that instruction-tuning language models like Claude and ChatGPT can understand layout by spaces and line breaks. Based on this observation, we propose the LAyout and Task aware Instruction Prompt (LATIN-Prompt), which consists of layout-aware document content and task-aware instruction. Specifically, the former uses appropriate spaces and line breaks to recover the layout information among text segments obtained by OCR tools, and the latter ensures that generated answers adhere to formatting requirements. Moreover, we propose the LAyout and Task aware Instruction Tuning (LATIN-Tuning) to improve the performance of small instruction-tuning models like Alpaca. Experimental results show that LATIN-Prompt enables zero-shot performance of Claude and ChatGPT to be comparable to the fine-tuning performance of SOTAs on document image question answering, and LATIN-Tuning enhances the zero-shot performance of Alpaca significantly. For example, LATIN-Prompt improves the performance of Claude and ChatGPT on DocVQA by 263% and 20% respectively. LATIN-Tuning improves the performance of Alpaca on DocVQA by 87.7%. Quantitative and qualitative analyses demonstrate the effectiveness of LATIN-Prompt and LATIN-Tuning. We provide the code in supplementary and will release it to facilitate future research.

NapSS: Paragraph-level Medical Text Simplification via Narrative Prompting and Sentence-matching Summarization

Accessing medical literature is difficult for laypeople as the content is written for specialists and contains medical jargon. Automated text simplification methods offer a potential means to address this issue. In this work, we propose a summarize-then-simplify two-stage strategy, which we call NapSS, identifying the relevant content to simplify while ensuring that the original narrative flow is preserved. In this approach, we first generate reference summaries via sentence matching between the original and the simplified abstracts. These summaries are then used to train an extractive summarizer, learning the most relevant content to be simplified. Then, to ensure the narrative consistency of the simplified text, we synthesize auxiliary narrative prompts combining key phrases derived from the syntactical analyses of the original text. Our model achieves results significantly better than the seq2seq baseline on an English medical corpus, yielding 3%~4% absolute improvements in terms of lexical similarity, and providing a further 1.1% improvement of SARI score when combined with the baseline. We also highlight shortcomings of existing evaluation methods, and introduce new metrics that take into account both lexical and high-level semantic similarity. A human evaluation conducted on a random sample of the test set further establishes the effectiveness of the proposed approach. Codes and models are released here: https://github.com/LuJunru/NapSS.

BhashaVerse : Translation Ecosystem for Indian Subcontinent Languages

This paper focuses on developing translation models and related applications for 36 Indian languages, including Assamese, Awadhi, Bengali, Bhojpuri, Braj, Bodo, Dogri, English, Konkani, Gondi, Gujarati, Hindi, Hinglish, Ho, Kannada, Kangri, Kashmiri (Arabic and Devanagari), Khasi, Mizo, Magahi, Maithili, Malayalam, Marathi, Manipuri (Bengali and Meitei), Nepali, Oriya, Punjabi, Sanskrit, Santali, Sinhala, Sindhi (Arabic and Devanagari), Tamil, Tulu, Telugu, and Urdu. Achieving this requires parallel and other types of corpora for all 36 * 36 language pairs, addressing challenges like script variations, phonetic differences, and syntactic diversity. For instance, languages like Kashmiri and Sindhi, which use multiple scripts, demand script normalization for alignment, while low-resource languages such as Khasi and Santali require synthetic data augmentation to ensure sufficient coverage and quality. To address these challenges, this work proposes strategies for corpus creation by leveraging existing resources, developing parallel datasets, generating domain-specific corpora, and utilizing synthetic data techniques. Additionally, it evaluates machine translation across various dimensions, including standard and discourse-level translation, domain-specific translation, reference-based and reference-free evaluation, error analysis, and automatic post-editing. By integrating these elements, the study establishes a comprehensive framework to improve machine translation quality and enable better cross-lingual communication in India's linguistically diverse ecosystem.

Doctors Handwritten Prescription Recognition System In Multi Language Using Deep Learning

Doctors typically write in incomprehensible handwriting, making it difficult for both the general public and some pharmacists to understand the medications they have prescribed. It is not ideal for them to write the prescription quietly and methodically because they will be dealing with dozens of patients every day and will be swamped with work.As a result, their handwriting is illegible. This may result in reports or prescriptions consisting of short forms and cursive writing that a typical person or pharmacist won't be able to read properly, which will cause prescribed medications to be misspelled. However, some individuals are accustomed to writing prescriptions in regional languages because we all live in an area with a diversity of regional languages. It makes analyzing the content much more challenging. So, in this project, we'll use a recognition system to build a tool that can translate the handwriting of physicians in any language. This system will be made into an application which is fully autonomous in functioning. As the user uploads the prescription image the program will pre-process the image by performing image pre-processing, and word segmentations initially before processing the image for training. And it will be done for every language we require the model to detect. And as of the deduction model will be made using deep learning techniques including CNN, RNN, and LSTM, which are utilized to train the model. To match words from various languages that will be written in the system, Unicode will be used. Furthermore, fuzzy search and market basket analysis are employed to offer an end result that will be optimized from the pharmaceutical database and displayed to the user as a structured output.

Data Generation for Post-OCR correction of Cyrillic handwriting

This paper introduces a novel approach to post-Optical Character Recognition Correction (POC) for handwritten Cyrillic text, addressing a significant gap in current research methodologies. This gap is due to the lack of large text corporas that provide OCR errors for further training of language-based POC models, which are demanding in terms of corpora size. Our study primarily focuses on the development and application of a synthetic handwriting generation engine based on B\'ezier curves. Such an engine generates highly realistic handwritten text in any amounts, which we utilize to create a substantial dataset by transforming Russian text corpora sourced from the internet. We apply a Handwritten Text Recognition (HTR) model to this dataset to identify OCR errors, forming the basis for our POC model training. The correction model is trained on a 90-symbol input context, utilizing a pre-trained T5 architecture with a seq2seq correction task. We evaluate our approach on HWR200 and School_notebooks_RU datasets as they provide significant challenges in the HTR domain. Furthermore, POC can be used to highlight errors for teachers, evaluating student performance. This can be done simply by comparing sentences before and after correction, displaying differences in text. Our primary contribution lies in the innovative use of B\'ezier curves for Cyrillic text generation and subsequent error correction using a specialized POC model. We validate our approach by presenting Word Accuracy Rate (WAR) and Character Accuracy Rate (CAR) results, both with and without post-OCR correction, using real open corporas of handwritten Cyrillic text. These results, coupled with our methodology, are designed to be reproducible, paving the way for further advancements in the field of OCR and handwritten text analysis. Paper contributions can be found in https://github.com/dbrainio/CyrillicHandwritingPOC

Single-Cell Omics Arena: A Benchmark Study for Large Language Models on Cell Type Annotation Using Single-Cell Data

Over the past decade, the revolution in single-cell sequencing has enabled the simultaneous molecular profiling of various modalities across thousands of individual cells, allowing scientists to investigate the diverse functions of complex tissues and uncover underlying disease mechanisms. Among all the analytical steps, assigning individual cells to specific types is fundamental for understanding cellular heterogeneity. However, this process is usually labor-intensive and requires extensive expert knowledge. Recent advances in large language models (LLMs) have demonstrated their ability to efficiently process and synthesize vast corpora of text to automatically extract essential biological knowledge, such as marker genes, potentially promoting more efficient and automated cell type annotations. To thoroughly evaluate the capability of modern instruction-tuned LLMs in automating the cell type identification process, we introduce SOAR, a comprehensive benchmarking study of LLMs for cell type annotation tasks in single-cell genomics. Specifically, we assess the performance of 8 instruction-tuned LLMs across 11 datasets, spanning multiple cell types and species. Our study explores the potential of LLMs to accurately classify and annotate cell types in single-cell RNA sequencing (scRNA-seq) data, while extending their application to multiomics data through cross-modality translation. Additionally, we evaluate the effectiveness of chain-of-thought (CoT) prompting techniques in generating detailed biological insights during the annotation process. The results demonstrate that LLMs can provide robust interpretations of single-cell data without requiring additional fine-tuning, advancing the automation of cell type annotation in genomics research.

IndicSTR12: A Dataset for Indic Scene Text Recognition

The importance of Scene Text Recognition (STR) in today's increasingly digital world cannot be overstated. Given the significance of STR, data intensive deep learning approaches that auto-learn feature mappings have primarily driven the development of STR solutions. Several benchmark datasets and substantial work on deep learning models are available for Latin languages to meet this need. On more complex, syntactically and semantically, Indian languages spoken and read by 1.3 billion people, there is less work and datasets available. This paper aims to address the Indian space's lack of a comprehensive dataset by proposing the largest and most comprehensive real dataset - IndicSTR12 - and benchmarking STR performance on 12 major Indian languages. A few works have addressed the same issue, but to the best of our knowledge, they focused on a small number of Indian languages. The size and complexity of the proposed dataset are comparable to those of existing Latin contemporaries, while its multilingualism will catalyse the development of robust text detection and recognition models. It was created specifically for a group of related languages with different scripts. The dataset contains over 27000 word-images gathered from various natural scenes, with over 1000 word-images for each language. Unlike previous datasets, the images cover a broader range of realistic conditions, including blur, illumination changes, occlusion, non-iconic texts, low resolution, perspective text etc. Along with the new dataset, we provide a high-performing baseline on three models - PARSeq, CRNN, and STARNet.

Zero-shot information extraction from radiological reports using ChatGPT

Electronic health records contain an enormous amount of valuable information, but many are recorded in free text. Information extraction is the strategy to transform the sequence of characters into structured data, which can be employed for secondary analysis. However, the traditional information extraction components, such as named entity recognition and relation extraction, require annotated data to optimize the model parameters, which has become one of the major bottlenecks in building information extraction systems. With the large language models achieving good performances on various downstream NLP tasks without parameter tuning, it becomes possible to use large language models for zero-shot information extraction. In this study, we aim to explore whether the most popular large language model, ChatGPT, can extract useful information from the radiological reports. We first design the prompt template for the interested information in the CT reports. Then, we generate the prompts by combining the prompt template with the CT reports as the inputs of ChatGPT to obtain the responses. A post-processing module is developed to transform the responses into structured extraction results. We conducted the experiments with 847 CT reports collected from Peking University Cancer Hospital. The experimental results indicate that ChatGPT can achieve competitive performances for some extraction tasks compared with the baseline information extraction system, but some limitations need to be further improved.

General Detection-based Text Line Recognition

We introduce a general detection-based approach to text line recognition, be it printed (OCR) or handwritten (HTR), with Latin, Chinese, or ciphered characters. Detection-based approaches have until now been largely discarded for HTR because reading characters separately is often challenging, and character-level annotation is difficult and expensive. We overcome these challenges thanks to three main insights: (i) synthetic pre-training with sufficiently diverse data enables learning reasonable character localization for any script; (ii) modern transformer-based detectors can jointly detect a large number of instances, and, if trained with an adequate masking strategy, leverage consistency between the different detections; (iii) once a pre-trained detection model with approximate character localization is available, it is possible to fine-tune it with line-level annotation on real data, even with a different alphabet. Our approach, dubbed DTLR, builds on a completely different paradigm than state-of-the-art HTR methods, which rely on autoregressive decoding, predicting character values one by one, while we treat a complete line in parallel. Remarkably, we demonstrate good performance on a large range of scripts, usually tackled with specialized approaches. In particular, we improve state-of-the-art performances for Chinese script recognition on the CASIA v2 dataset, and for cipher recognition on the Borg and Copiale datasets. Our code and models are available at https://github.com/raphael-baena/DTLR.

Tails Tell Tales: Chapter-Wide Manga Transcriptions with Character Names

Enabling engagement of manga by visually impaired individuals presents a significant challenge due to its inherently visual nature. With the goal of fostering accessibility, this paper aims to generate a dialogue transcript of a complete manga chapter, entirely automatically, with a particular emphasis on ensuring narrative consistency. This entails identifying (i) what is being said, i.e., detecting the texts on each page and classifying them into essential vs non-essential, and (ii) who is saying it, i.e., attributing each dialogue to its speaker, while ensuring the same characters are named consistently throughout the chapter. To this end, we introduce: (i) Magiv2, a model that is capable of generating high-quality chapter-wide manga transcripts with named characters and significantly higher precision in speaker diarisation over prior works; (ii) an extension of the PopManga evaluation dataset, which now includes annotations for speech-bubble tail boxes, associations of text to corresponding tails, classifications of text as essential or non-essential, and the identity for each character box; and (iii) a new character bank dataset, which comprises over 11K characters from 76 manga series, featuring 11.5K exemplar character images in total, as well as a list of chapters in which they appear. The code, trained model, and both datasets can be found at: https://github.com/ragavsachdeva/magi

edATLAS: An Efficient Disambiguation Algorithm for Texting in Languages with Abugida Scripts

Abugida refers to a phonogram writing system where each syllable is represented using a single consonant or typographic ligature, along with a default vowel or optional diacritic(s) to denote other vowels. However, texting in these languages has some unique challenges in spite of the advent of devices with soft keyboard supporting custom key layouts. The number of characters in these languages is large enough to require characters to be spread over multiple views in the layout. Having to switch between views many times to type a single word hinders the natural thought process. This prevents popular usage of native keyboard layouts. On the other hand, supporting romanized scripts (native words transcribed using Latin characters) with language model based suggestions is also set back by the lack of uniform romanization rules. To this end, we propose a disambiguation algorithm and showcase its usefulness in two novel mutually non-exclusive input methods for languages natively using the abugida writing system: (a) disambiguation of ambiguous input for abugida scripts, and (b) disambiguation of word variants in romanized scripts. We benchmark these approaches using public datasets, and show an improvement in typing speed by 19.49%, 25.13%, and 14.89%, in Hindi, Bengali, and Thai, respectively, using Ambiguous Input, owing to the human ease of locating keys combined with the efficiency of our inference method. Our Word Variant Disambiguation (WDA) maps valid variants of romanized words, previously treated as Out-of-Vocab, to a vocabulary of 100k words with high accuracy, leading to an increase in Error Correction F1 score by 10.03% and Next Word Prediction (NWP) by 62.50% on average.

A Biomedical Entity Extraction Pipeline for Oncology Health Records in Portuguese

Textual health records of cancer patients are usually protracted and highly unstructured, making it very time-consuming for health professionals to get a complete overview of the patient's therapeutic course. As such limitations can lead to suboptimal and/or inefficient treatment procedures, healthcare providers would greatly benefit from a system that effectively summarizes the information of those records. With the advent of deep neural models, this objective has been partially attained for English clinical texts, however, the research community still lacks an effective solution for languages with limited resources. In this paper, we present the approach we developed to extract procedures, drugs, and diseases from oncology health records written in European Portuguese. This project was conducted in collaboration with the Portuguese Institute for Oncology which, besides holding over 10 years of duly protected medical records, also provided oncologist expertise throughout the development of the project. Since there is no annotated corpus for biomedical entity extraction in Portuguese, we also present the strategy we followed in annotating the corpus for the development of the models. The final models, which combined a neural architecture with entity linking, achieved F_1 scores of 88.6, 95.0, and 55.8 per cent in the mention extraction of procedures, drugs, and diseases, respectively.

ESB: A Benchmark For Multi-Domain End-to-End Speech Recognition

Speech recognition applications cover a range of different audio and text distributions, with different speaking styles, background noise, transcription punctuation and character casing. However, many speech recognition systems require dataset-specific tuning (audio filtering, punctuation removal and normalisation of casing), therefore assuming a-priori knowledge of both the audio and text distributions. This tuning requirement can lead to systems failing to generalise to other datasets and domains. To promote the development of multi-domain speech systems, we introduce the End-to-end Speech Benchmark (ESB) for evaluating the performance of a single automatic speech recognition (ASR) system across a broad set of speech datasets. Benchmarked systems must use the same data pre- and post-processing algorithm across datasets - assuming the audio and text data distributions are a-priori unknown. We compare a series of state-of-the-art (SoTA) end-to-end (E2E) systems on this benchmark, demonstrating how a single speech system can be applied and evaluated on a wide range of data distributions. We find E2E systems to be effective across datasets: in a fair comparison, E2E systems achieve within 2.6% of SoTA systems tuned to a specific dataset. Our analysis reveals that transcription artefacts, such as punctuation and casing, pose difficulties for ASR systems and should be included in evaluation. We believe E2E benchmarking over a range of datasets promotes the research of multi-domain speech recognition systems. ESB is available at https://huggingface.co/esb.

DocGenome: An Open Large-scale Scientific Document Benchmark for Training and Testing Multi-modal Large Language Models

Scientific documents record research findings and valuable human knowledge, comprising a vast corpus of high-quality data. Leveraging multi-modality data extracted from these documents and assessing large models' abilities to handle scientific document-oriented tasks is therefore meaningful. Despite promising advancements, large models still perform poorly on multi-page scientific document extraction and understanding tasks, and their capacity to process within-document data formats such as charts and equations remains under-explored. To address these issues, we present DocGenome, a structured document benchmark constructed by annotating 500K scientific documents from 153 disciplines in the arXiv open-access community, using our custom auto-labeling pipeline. DocGenome features four key characteristics: 1) Completeness: It is the first dataset to structure data from all modalities including 13 layout attributes along with their LaTeX source codes. 2) Logicality: It provides 6 logical relationships between different entities within each scientific document. 3) Diversity: It covers various document-oriented tasks, including document classification, visual grounding, document layout detection, document transformation, open-ended single-page QA and multi-page QA. 4) Correctness: It undergoes rigorous quality control checks conducted by a specialized team. We conduct extensive experiments to demonstrate the advantages of DocGenome and objectively evaluate the performance of large models on our benchmark.

TransMI: A Framework to Create Strong Baselines from Multilingual Pretrained Language Models for Transliterated Data

Transliterating related languages that use different scripts into a common script shows effectiveness in improving crosslingual transfer in downstream tasks. However, this methodology often makes pretraining a model from scratch unavoidable, as transliteration brings about new subwords not covered in existing multilingual pretrained language models (mPLMs). This is not desired because it takes a lot of computation budget for pretraining. A more promising way is to make full use of available mPLMs. To this end, this paper proposes a simple but effective framework: Transliterate-Merge-Initialize (TransMI), which can create a strong baseline well-suited for data that is transliterated into a common script by exploiting an mPLM and its accompanied tokenizer. TransMI has three stages: (a) transliterate the vocabulary of an mPLM into a common script; (b) merge the new vocabulary with the original vocabulary; and (c) initialize the embeddings of the new subwords. We applied TransMI to three recent strong mPLMs, and our experiments demonstrate that TransMI not only preserves their ability to handle non-transliterated data, but also enables the models to effectively process transliterated data: the results show a consistent improvement of 3% to 34%, varying across different models and tasks. We make our code and models publicly available at https://github.com/cisnlp/TransMI.

Improving Medical Reasoning through Retrieval and Self-Reflection with Retrieval-Augmented Large Language Models

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that still cannot be handled with the encoded knowledge of LLMs, various retrieval-augmented generation (RAG) methods have been developed by searching documents from the knowledge corpus and appending them unconditionally or selectively to the input of LLMs for generation. However, when applying existing methods to different domain-specific problems, poor generalization becomes apparent, leading to fetching incorrect documents or making inaccurate judgments. In this paper, we introduce Self-BioRAG, a framework reliable for biomedical text that specializes in generating explanations, retrieving domain-specific documents, and self-reflecting generated responses. We utilize 84k filtered biomedical instruction sets to train Self-BioRAG that can assess its generated explanations with customized reflective tokens. Our work proves that domain-specific components, such as a retriever, domain-related document corpus, and instruction sets are necessary for adhering to domain-related instructions. Using three major medical question-answering benchmark datasets, experimental results of Self-BioRAG demonstrate significant performance gains by achieving a 7.2% absolute improvement on average over the state-of-the-art open-foundation model with a parameter size of 7B or less. Overall, we analyze that Self-BioRAG finds the clues in the question, retrieves relevant documents if needed, and understands how to answer with information from retrieved documents and encoded knowledge as a medical expert does. We release our data and code for training our framework components and model weights (7B and 13B) to enhance capabilities in biomedical and clinical domains.

DocCGen: Document-based Controlled Code Generation

Recent developments show that Large Language Models (LLMs) produce state-of-the-art performance on natural language (NL) to code generation for resource-rich general-purpose languages like C++, Java, and Python. However, their practical usage for structured domain-specific languages (DSLs) such as YAML, JSON is limited due to domain-specific schema, grammar, and customizations generally unseen by LLMs during pre-training. Efforts have been made to mitigate this challenge via in-context learning through relevant examples or by fine-tuning. However, it suffers from problems, such as limited DSL samples and prompt sensitivity but enterprises maintain good documentation of the DSLs. Therefore, we propose DocCGen, a framework that can leverage such rich knowledge by breaking the NL-to-Code generation task for structured code languages into a two-step process. First, it detects the correct libraries using the library documentation that best matches the NL query. Then, it utilizes schema rules extracted from the documentation of these libraries to constrain the decoding. We evaluate our framework for two complex structured languages, Ansible YAML and Bash command, consisting of two settings: Out-of-domain (OOD) and In-domain (ID). Our extensive experiments show that DocCGen consistently improves different-sized language models across all six evaluation metrics, reducing syntactic and semantic errors in structured code. We plan to open-source the datasets and code to motivate research in constrained code generation.

GECTurk: Grammatical Error Correction and Detection Dataset for Turkish

Grammatical Error Detection and Correction (GEC) tools have proven useful for native speakers and second language learners. Developing such tools requires a large amount of parallel, annotated data, which is unavailable for most languages. Synthetic data generation is a common practice to overcome the scarcity of such data. However, it is not straightforward for morphologically rich languages like Turkish due to complex writing rules that require phonological, morphological, and syntactic information. In this work, we present a flexible and extensible synthetic data generation pipeline for Turkish covering more than 20 expert-curated grammar and spelling rules (a.k.a., writing rules) implemented through complex transformation functions. Using this pipeline, we derive 130,000 high-quality parallel sentences from professionally edited articles. Additionally, we create a more realistic test set by manually annotating a set of movie reviews. We implement three baselines formulating the task as i) neural machine translation, ii) sequence tagging, and iii) prefix tuning with a pretrained decoder-only model, achieving strong results. Furthermore, we perform exhaustive experiments on out-of-domain datasets to gain insights on the transferability and robustness of the proposed approaches. Our results suggest that our corpus, GECTurk, is high-quality and allows knowledge transfer for the out-of-domain setting. To encourage further research on Turkish GEC, we release our datasets, baseline models, and the synthetic data generation pipeline at https://github.com/GGLAB-KU/gecturk.

Can open source large language models be used for tumor documentation in Germany? -- An evaluation on urological doctors' notes

Tumor documentation in Germany is largely done manually, requiring reading patient records and entering data into structured databases. Large language models (LLMs) could potentially enhance this process by improving efficiency and reliability. This evaluation tests eleven different open source LLMs with sizes ranging from 1-70 billion model parameters on three basic tasks of the tumor documentation process: identifying tumor diagnoses, assigning ICD-10 codes, and extracting the date of first diagnosis. For evaluating the LLMs on these tasks, a dataset of annotated text snippets based on anonymized doctors' notes from urology was prepared. Different prompting strategies were used to investigate the effect of the number of examples in few-shot prompting and to explore the capabilities of the LLMs in general. The models Llama 3.1 8B, Mistral 7B, and Mistral NeMo 12 B performed comparably well in the tasks. Models with less extensive training data or having fewer than 7 billion parameters showed notably lower performance, while larger models did not display performance gains. Examples from a different medical domain than urology could also improve the outcome in few-shot prompting, which demonstrates the ability of LLMs to handle tasks needed for tumor documentation. Open source LLMs show a strong potential for automating tumor documentation. Models from 7-12 billion parameters could offer an optimal balance between performance and resource efficiency. With tailored fine-tuning and well-designed prompting, these models might become important tools for clinical documentation in the future. The code for the evaluation is available from https://github.com/stefan-m-lenz/UroLlmEval. We also release the dataset as a new valuable resource that addresses the shortage of authentic and easily accessible benchmarks in German-language medical NLP.

Towards Unifying Medical Vision-and-Language Pre-training via Soft Prompts

Medical vision-and-language pre-training (Med-VLP) has shown promising improvements on many downstream medical tasks owing to its applicability to extracting generic representations from medical images and texts. Practically, there exist two typical types, i.e., the fusion-encoder type and the dual-encoder type, depending on whether a heavy fusion module is used. The former is superior at multi-modal tasks owing to the sufficient interaction between modalities; the latter is good at uni-modal and cross-modal tasks due to the single-modality encoding ability. To take advantage of these two types, we propose an effective yet straightforward scheme named PTUnifier to unify the two types. We first unify the input format by introducing visual and textual prompts, which serve as a feature bank that stores the most representative images/texts. By doing so, a single model could serve as a foundation model that processes various tasks adopting different input formats (i.e., image-only, text-only, and image-text-pair). Furthermore, we construct a prompt pool (instead of static ones) to improve diversity and scalability. Experimental results show that our approach achieves state-of-the-art results on a broad range of tasks, spanning uni-modal tasks (i.e., image/text classification and text summarization), cross-modal tasks (i.e., image-to-text generation and image-text/text-image retrieval), and multi-modal tasks (i.e., visual question answering), demonstrating the effectiveness of our approach. Note that the adoption of prompts is orthogonal to most existing Med-VLP approaches and could be a beneficial and complementary extension to these approaches.

Efficient Pre-training for Localized Instruction Generation of Videos

Procedural videos, exemplified by recipe demonstrations, are instrumental in conveying step-by-step instructions. However, understanding such videos is challenging as it involves the precise localization of steps and the generation of textual instructions. Manually annotating steps and writing instructions is costly, which limits the size of current datasets and hinders effective learning. Leveraging large but noisy video-transcript datasets for pre-training can boost performance but demands significant computational resources. Furthermore, transcripts contain irrelevant content and differ in style from human-written instructions. To mitigate these issues, we propose a novel technique, Sieve-&-Swap, to automatically generate high-quality training data for the recipe domain: (i) Sieve: filters irrelevant transcripts and (ii) Swap: acquires high-quality text by replacing transcripts with human-written instruction from a text-only recipe dataset. The resulting dataset is three orders of magnitude smaller than current web-scale datasets but enables efficient training of large-scale models. Alongside Sieve-&-Swap, we propose Procedure Transformer (ProcX), a model for end-to-end step localization and instruction generation for procedural videos. When pre-trained on our curated dataset, this model achieves state-of-the-art performance on YouCook2 and Tasty while using a fraction of the training data. We have released code and dataset.

PyGen: A Collaborative Human-AI Approach to Python Package Creation

The principles of automation and innovation serve as foundational elements for advancement in contemporary science and technology. Here, we introduce Pygen, an automation platform designed to empower researchers, technologists, and hobbyists to bring abstract ideas to life as core, usable software tools written in Python. Pygen leverages the immense power of autoregressive large language models to augment human creativity during the ideation, iteration, and innovation process. By combining state-of-the-art language models with open-source code generation technologies, Pygen has significantly reduced the manual overhead of tool development. From a user prompt, Pygen automatically generates Python packages for a complete workflow from concept to package generation and documentation. The findings of our work show that Pygen considerably enhances the researcher's productivity by enabling the creation of resilient, modular, and well-documented packages for various specialized purposes. We employ a prompt enhancement approach to distill the user's package description into increasingly specific and actionable. While being inherently an open-ended task, we have evaluated the generated packages and the documentation using Human Evaluation, LLM-based evaluation, and CodeBLEU, with detailed results in the results section. Furthermore, we documented our results, analyzed the limitations, and suggested strategies to alleviate them. Pygen is our vision of ethical automation, a framework that promotes inclusivity, accessibility, and collaborative development. This project marks the beginning of a large-scale effort towards creating tools where intelligent agents collaborate with humans to improve scientific and technological development substantially. Our code and generated examples are open-sourced at [https://github.com/GitsSaikat/Pygen]

An open dataset for the evolution of oracle bone characters: EVOBC

The earliest extant Chinese characters originate from oracle bone inscriptions, which are closely related to other East Asian languages. These inscriptions hold immense value for anthropology and archaeology. However, deciphering oracle bone script remains a formidable challenge, with only approximately 1,600 of the over 4,500 extant characters elucidated to date. Further scholarly investigation is required to comprehensively understand this ancient writing system. Artificial Intelligence technology is a promising avenue for deciphering oracle bone characters, particularly concerning their evolution. However, one of the challenges is the lack of datasets mapping the evolution of these characters over time. In this study, we systematically collected ancient characters from authoritative texts and websites spanning six historical stages: Oracle Bone Characters - OBC (15th century B.C.), Bronze Inscriptions - BI (13th to 221 B.C.), Seal Script - SS (11th to 8th centuries B.C.), Spring and Autumn period Characters - SAC (770 to 476 B.C.), Warring States period Characters - WSC (475 B.C. to 221 B.C.), and Clerical Script - CS (221 B.C. to 220 A.D.). Subsequently, we constructed an extensive dataset, namely EVolution Oracle Bone Characters (EVOBC), consisting of 229,170 images representing 13,714 distinct character categories. We conducted validation and simulated deciphering on the constructed dataset, and the results demonstrate its high efficacy in aiding the study of oracle bone script. This openly accessible dataset aims to digitalize ancient Chinese scripts across multiple eras, facilitating the decipherment of oracle bone script by examining the evolution of glyph forms.

Cross-Lingual Transfer from Related Languages: Treating Low-Resource Maltese as Multilingual Code-Switching

Although multilingual language models exhibit impressive cross-lingual transfer capabilities on unseen languages, the performance on downstream tasks is impacted when there is a script disparity with the languages used in the multilingual model's pre-training data. Using transliteration offers a straightforward yet effective means to align the script of a resource-rich language with a target language, thereby enhancing cross-lingual transfer capabilities. However, for mixed languages, this approach is suboptimal, since only a subset of the language benefits from the cross-lingual transfer while the remainder is impeded. In this work, we focus on Maltese, a Semitic language, with substantial influences from Arabic, Italian, and English, and notably written in Latin script. We present a novel dataset annotated with word-level etymology. We use this dataset to train a classifier that enables us to make informed decisions regarding the appropriate processing of each token in the Maltese language. We contrast indiscriminate transliteration or translation to mixing processing pipelines that only transliterate words of Arabic origin, thereby resulting in text with a mixture of scripts. We fine-tune the processed data on four downstream tasks and show that conditional transliteration based on word etymology yields the best results, surpassing fine-tuning with raw Maltese or Maltese processed with non-selective pipelines.

MidiCaps -- A large-scale MIDI dataset with text captions

Generative models guided by text prompts are increasingly becoming more popular. However, no text-to-MIDI models currently exist, mostly due to the lack of a captioned MIDI dataset. This work aims to enable research that combines LLMs with symbolic music by presenting the first large-scale MIDI dataset with text captions that is openly available: MidiCaps. MIDI (Musical Instrument Digital Interface) files are a widely used format for encoding musical information. Their structured format captures the nuances of musical composition and has practical applications by music producers, composers, musicologists, as well as performers. Inspired by recent advancements in captioning techniques applied to various domains, we present a large-scale curated dataset of over 168k MIDI files accompanied by textual descriptions. Each MIDI caption succinctly describes the musical content, encompassing tempo, chord progression, time signature, instruments present, genre and mood; thereby facilitating multi-modal exploration and analysis. The dataset contains a mix of various genres, styles, and complexities, offering a rich source for training and evaluating models for tasks such as music information retrieval, music understanding and cross-modal translation. We provide detailed statistics about the dataset and have assessed the quality of the captions in an extensive listening study. We anticipate that this resource will stimulate further research in the intersection of music and natural language processing, fostering advancements in both fields.

More efficient manual review of automatically transcribed tabular data

Machine learning methods have proven useful in transcribing historical data. However, results from even highly accurate methods require manual verification and correction. Such manual review can be time-consuming and expensive, therefore the objective of this paper was to make it more efficient. Previously, we used machine learning to transcribe 2.3 million handwritten occupation codes from the Norwegian 1950 census with high accuracy (97%). We manually reviewed the 90,000 (3%) codes with the lowest model confidence. We allocated those 90,000 codes to human reviewers, who used our annotation tool to review the codes. To assess reviewer agreement, some codes were assigned to multiple reviewers. We then analyzed the review results to understand the relationship between accuracy improvements and effort. Additionally, we interviewed the reviewers to improve the workflow. The reviewers corrected 62.8% of the labels and agreed with the model label in 31.9% of cases. About 0.2% of the images could not be assigned a label, while for 5.1% the reviewers were uncertain, or they assigned an invalid label. 9,000 images were independently reviewed by multiple reviewers, resulting in an agreement of 86.43% and disagreement of 8.96%. We learned that our automatic transcription is biased towards the most frequent codes, with a higher degree of misclassification for the lowest frequency codes. Our interview findings show that the reviewers did internal quality control and found our custom tool well-suited. So, only one reviewer is needed, but they should report uncertainty.

BigDocs: An Open and Permissively-Licensed Dataset for Training Multimodal Models on Document and Code Tasks

Multimodal AI has the potential to significantly enhance document-understanding tasks, such as processing receipts, understanding workflows, extracting data from documents, and summarizing reports. Code generation tasks that require long-structured outputs can also be enhanced by multimodality. Despite this, their use in commercial applications is often limited due to limited access to training data and restrictive licensing, which hinders open access. To address these limitations, we introduce BigDocs-7.5M, a high-quality, open-access dataset comprising 7.5 million multimodal documents across 30 tasks. We use an efficient data curation process to ensure our data is high-quality and license-permissive. Our process emphasizes accountability, responsibility, and transparency through filtering rules, traceable metadata, and careful content analysis. Additionally, we introduce BigDocs-Bench, a benchmark suite with 10 novel tasks where we create datasets that reflect real-world use cases involving reasoning over Graphical User Interfaces (GUI) and code generation from images. Our experiments show that training with BigDocs-Bench improves average performance up to 25.8% over closed-source GPT-4o in document reasoning and structured output tasks such as Screenshot2HTML or Image2Latex generation. Finally, human evaluations showed a preference for outputs from models trained on BigDocs over GPT-4o. This suggests that BigDocs can help both academics and the open-source community utilize and improve AI tools to enhance multimodal capabilities and document reasoning. The project is hosted at https://bigdocs.github.io .

GENERator: A Long-Context Generative Genomic Foundation Model

Advancements in DNA sequencing technologies have significantly improved our ability to decode genomic sequences. However, the prediction and interpretation of these sequences remain challenging due to the intricate nature of genetic material. Large language models (LLMs) have introduced new opportunities for biological sequence analysis. Recent developments in genomic language models have underscored the potential of LLMs in deciphering DNA sequences. Nonetheless, existing models often face limitations in robustness and application scope, primarily due to constraints in model structure and training data scale. To address these limitations, we present GENERator, a generative genomic foundation model featuring a context length of 98k base pairs (bp) and 1.2B parameters. Trained on an expansive dataset comprising 386B bp of eukaryotic DNA, the GENERator demonstrates state-of-the-art performance across both established and newly proposed benchmarks. The model adheres to the central dogma of molecular biology, accurately generating protein-coding sequences that translate into proteins structurally analogous to known families. It also shows significant promise in sequence optimization, particularly through the prompt-responsive generation of promoter sequences with specific activity profiles. These capabilities position the GENERator as a pivotal tool for genomic research and biotechnological advancement, enhancing our ability to interpret and predict complex biological systems and enabling precise genomic interventions.

AutoMIR: Effective Zero-Shot Medical Information Retrieval without Relevance Labels

Medical information retrieval (MIR) is essential for retrieving relevant medical knowledge from diverse sources, including electronic health records, scientific literature, and medical databases. However, achieving effective zero-shot dense retrieval in the medical domain poses substantial challenges due to the lack of relevance-labeled data. In this paper, we introduce a novel approach called Self-Learning Hypothetical Document Embeddings (SL-HyDE) to tackle this issue. SL-HyDE leverages large language models (LLMs) as generators to generate hypothetical documents based on a given query. These generated documents encapsulate key medical context, guiding a dense retriever in identifying the most relevant documents. The self-learning framework progressively refines both pseudo-document generation and retrieval, utilizing unlabeled medical corpora without requiring any relevance-labeled data. Additionally, we present the Chinese Medical Information Retrieval Benchmark (CMIRB), a comprehensive evaluation framework grounded in real-world medical scenarios, encompassing five tasks and ten datasets. By benchmarking ten models on CMIRB, we establish a rigorous standard for evaluating medical information retrieval systems. Experimental results demonstrate that SL-HyDE significantly surpasses existing methods in retrieval accuracy while showcasing strong generalization and scalability across various LLM and retriever configurations. CMIRB data and evaluation code are publicly available at: https://github.com/CMIRB-benchmark/CMIRB.

Machine Translation by Projecting Text into the Same Phonetic-Orthographic Space Using a Common Encoding

The use of subword embedding has proved to be a major innovation in Neural Machine Translation (NMT). It helps NMT to learn better context vectors for Low Resource Languages (LRLs) so as to predict the target words by better modelling the morphologies of the two languages and also the morphosyntax transfer. Even so, their performance for translation in Indian language to Indian language scenario is still not as good as for resource-rich languages. One reason for this is the relative morphological richness of Indian languages, while another is that most of them fall into the extremely low resource or zero-shot categories. Since most major Indian languages use Indic or Brahmi origin scripts, the text written in them is highly phonetic in nature and phonetically similar in terms of abstract letters and their arrangements. We use these characteristics of Indian languages and their scripts to propose an approach based on common multilingual Latin-based encodings (WX notation) that take advantage of language similarity while addressing the morphological complexity issue in NMT. These multilingual Latin-based encodings in NMT, together with Byte Pair Embedding (BPE) allow us to better exploit their phonetic and orthographic as well as lexical similarities to improve the translation quality by projecting different but similar languages on the same orthographic-phonetic character space. We verify the proposed approach by demonstrating experiments on similar language pairs (Gujarati-Hindi, Marathi-Hindi, Nepali-Hindi, Maithili-Hindi, Punjabi-Hindi, and Urdu-Hindi) under low resource conditions. The proposed approach shows an improvement in a majority of cases, in one case as much as ~10 BLEU points compared to baseline techniques for similar language pairs. We also get up to ~1 BLEU points improvement on distant and zero-shot language pairs.

SLUE: New Benchmark Tasks for Spoken Language Understanding Evaluation on Natural Speech

Progress in speech processing has been facilitated by shared datasets and benchmarks. Historically these have focused on automatic speech recognition (ASR), speaker identification, or other lower-level tasks. Interest has been growing in higher-level spoken language understanding tasks, including using end-to-end models, but there are fewer annotated datasets for such tasks. At the same time, recent work shows the possibility of pre-training generic representations and then fine-tuning for several tasks using relatively little labeled data. We propose to create a suite of benchmark tasks for Spoken Language Understanding Evaluation (SLUE) consisting of limited-size labeled training sets and corresponding evaluation sets. This resource would allow the research community to track progress, evaluate pre-trained representations for higher-level tasks, and study open questions such as the utility of pipeline versus end-to-end approaches. We present the first phase of the SLUE benchmark suite, consisting of named entity recognition, sentiment analysis, and ASR on the corresponding datasets. We focus on naturally produced (not read or synthesized) speech, and freely available datasets. We provide new transcriptions and annotations on subsets of the VoxCeleb and VoxPopuli datasets, evaluation metrics and results for baseline models, and an open-source toolkit to reproduce the baselines and evaluate new models.

Few-Shot Detection of Machine-Generated Text using Style Representations

The advent of instruction-tuned language models that convincingly mimic human writing poses a significant risk of abuse. However, such abuse may be counteracted with the ability to detect whether a piece of text was composed by a language model rather than a human author. Some previous approaches to this problem have relied on supervised methods by training on corpora of confirmed human- and machine- written documents. Unfortunately, model under-specification poses an unavoidable challenge for neural network-based detectors, making them brittle in the face of data shifts, such as the release of newer language models producing still more fluent text than the models used to train the detectors. Other approaches require access to the models that may have generated a document in question, which is often impractical. In light of these challenges, we pursue a fundamentally different approach not relying on samples from language models of concern at training time. Instead, we propose to leverage representations of writing style estimated from human-authored text. Indeed, we find that features effective at distinguishing among human authors are also effective at distinguishing human from machine authors, including state-of-the-art large language models like Llama-2, ChatGPT, and GPT-4. Furthermore, given a handful of examples composed by each of several specific language models of interest, our approach affords the ability to predict which model generated a given document. The code and data to reproduce our experiments are available at https://github.com/LLNL/LUAR/tree/main/fewshot_iclr2024.

ChatGPT-powered Conversational Drug Editing Using Retrieval and Domain Feedback

Recent advancements in conversational large language models (LLMs), such as ChatGPT, have demonstrated remarkable promise in various domains, including drug discovery. However, existing works mainly focus on investigating the capabilities of conversational LLMs on chemical reaction and retrosynthesis. While drug editing, a critical task in the drug discovery pipeline, remains largely unexplored. To bridge this gap, we propose ChatDrug, a framework to facilitate the systematic investigation of drug editing using LLMs. ChatDrug jointly leverages a prompt module, a retrieval and domain feedback (ReDF) module, and a conversation module to streamline effective drug editing. We empirically show that ChatDrug reaches the best performance on 33 out of 39 drug editing tasks, encompassing small molecules, peptides, and proteins. We further demonstrate, through 10 case studies, that ChatDrug can successfully identify the key substructures (e.g., the molecule functional groups, peptide motifs, and protein structures) for manipulation, generating diverse and valid suggestions for drug editing. Promisingly, we also show that ChatDrug can offer insightful explanations from a domain-specific perspective, enhancing interpretability and enabling informed decision-making. This research sheds light on the potential of ChatGPT and conversational LLMs for drug editing. It paves the way for a more efficient and collaborative drug discovery pipeline, contributing to the advancement of pharmaceutical research and development.

PromptTTS 2: Describing and Generating Voices with Text Prompt

Speech conveys more information than just text, as the same word can be uttered in various voices to convey diverse information. Compared to traditional text-to-speech (TTS) methods relying on speech prompts (reference speech) for voice variability, using text prompts (descriptions) is more user-friendly since speech prompts can be hard to find or may not exist at all. TTS approaches based on the text prompt face two challenges: 1) the one-to-many problem, where not all details about voice variability can be described in the text prompt, and 2) the limited availability of text prompt datasets, where vendors and large cost of data labeling are required to write text prompt for speech. In this work, we introduce PromptTTS 2 to address these challenges with a variation network to provide variability information of voice not captured by text prompts, and a prompt generation pipeline to utilize the large language models (LLM) to compose high quality text prompts. Specifically, the variation network predicts the representation extracted from the reference speech (which contains full information about voice) based on the text prompt representation. For the prompt generation pipeline, it generates text prompts for speech with a speech understanding model to recognize voice attributes (e.g., gender, speed) from speech and a large language model to formulate text prompt based on the recognition results. Experiments on a large-scale (44K hours) speech dataset demonstrate that compared to the previous works, PromptTTS 2 generates voices more consistent with text prompts and supports the sampling of diverse voice variability, thereby offering users more choices on voice generation. Additionally, the prompt generation pipeline produces high-quality prompts, eliminating the large labeling cost. The demo page of PromptTTS 2 is available onlinehttps://speechresearch.github.io/prompttts2.

BioMedGPT: Open Multimodal Generative Pre-trained Transformer for BioMedicine

Foundation models (FMs) have exhibited remarkable performance across a wide range of downstream tasks in many domains. Nevertheless, general-purpose FMs often face challenges when confronted with domain-specific problems, due to their limited access to the proprietary training data in a particular domain. In biomedicine, there are various biological modalities, such as molecules, proteins, and cells, which are encoded by the language of life and exhibit significant modality gaps with human natural language. In this paper, we introduce BioMedGPT, an open multimodal generative pre-trained transformer (GPT) for biomedicine, to bridge the gap between the language of life and human natural language. BioMedGPT allows users to easily ``communicate'' with diverse biological modalities through free text, which is the first of its kind. BioMedGPT aligns different biological modalities with natural language via a large generative language model, namely, BioMedGPT-LM. We publish BioMedGPT-10B, which unifies the feature spaces of molecules, proteins, and natural language via encoding and alignment. Through fine-tuning, BioMedGPT-10B outperforms or is on par with human and significantly larger general-purpose foundation models on the biomedical QA task. It also demonstrates promising performance in the molecule QA and protein QA tasks, which could greatly accelerate the discovery of new drugs and therapeutic targets. In addition, BioMedGPT-LM-7B is the first large generative language model based on Llama2 in the biomedical domain, therefore is commercial friendly. Both BioMedGPT-10B and BioMedGPT-LM-7B are open-sourced to the research community. In addition, we publish the datasets that are meticulously curated for the alignment of multi-modalities, i.e., PubChemQA and UniProtQA. All the models, codes, and datasets are available at https://github.com/PharMolix/OpenBioMed.

Large Language Models and Control Mechanisms Improve Text Readability of Biomedical Abstracts

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to automate such tasks allows for quick and direct accessibility for lay readers. In this work, we investigate the ability of state-of-the-art large language models (LLMs) on the task of biomedical abstract simplification, using the publicly available dataset for plain language adaptation of biomedical abstracts (PLABA). The methods applied include domain fine-tuning and prompt-based learning (PBL) on: 1) Encoder-decoder models (T5, SciFive, and BART), 2) Decoder-only GPT models (GPT-3.5 and GPT-4) from OpenAI and BioGPT, and 3) Control-token mechanisms on BART-based models. We used a range of automatic evaluation metrics, including BLEU, ROUGE, SARI, and BERTscore, and also conducted human evaluations. BART-Large with Control Token (BART-L-w-CT) mechanisms reported the highest SARI score of 46.54 and T5-base reported the highest BERTscore 72.62. In human evaluation, BART-L-w-CTs achieved a better simplicity score over T5-Base (2.9 vs. 2.2), while T5-Base achieved a better meaning preservation score over BART-L-w-CTs (3.1 vs. 2.6). We also categorised the system outputs with examples, hoping this will shed some light for future research on this task. Our code, fine-tuned models, and data splits are available at https://github.com/HECTA-UoM/PLABA-MU

The ParlaSpeech Collection of Automatically Generated Speech and Text Datasets from Parliamentary Proceedings

Recent significant improvements in speech and language technologies come both from self-supervised approaches over raw language data as well as various types of explicit supervision. To ensure high-quality processing of spoken data, the most useful type of explicit supervision is still the alignment between the speech signal and its corresponding text transcript, which is a data type that is not available for many languages. In this paper, we present our approach to building large and open speech-and-text-aligned datasets of less-resourced languages based on transcripts of parliamentary proceedings and their recordings. Our starting point are the ParlaMint comparable corpora of transcripts of parliamentary proceedings of 26 national European parliaments. In the pilot run on expanding the ParlaMint corpora with aligned publicly available recordings, we focus on three Slavic languages, namely Croatian, Polish, and Serbian. The main challenge of our approach is the lack of any global alignment between the ParlaMint texts and the available recordings, as well as the sometimes varying data order in each of the modalities, which requires a novel approach in aligning long sequences of text and audio in a large search space. The results of this pilot run are three high-quality datasets that span more than 5,000 hours of speech and accompanying text transcripts. Although these datasets already make a huge difference in the availability of spoken and textual data for the three languages, we want to emphasize the potential of the presented approach in building similar datasets for many more languages.

VoxInstruct: Expressive Human Instruction-to-Speech Generation with Unified Multilingual Codec Language Modelling

Recent AIGC systems possess the capability to generate digital multimedia content based on human language instructions, such as text, image and video. However, when it comes to speech, existing methods related to human instruction-to-speech generation exhibit two limitations. Firstly, they require the division of inputs into content prompt (transcript) and description prompt (style and speaker), instead of directly supporting human instruction. This division is less natural in form and does not align with other AIGC models. Secondly, the practice of utilizing an independent description prompt to model speech style, without considering the transcript content, restricts the ability to control speech at a fine-grained level. To address these limitations, we propose VoxInstruct, a novel unified multilingual codec language modeling framework that extends traditional text-to-speech tasks into a general human instruction-to-speech task. Our approach enhances the expressiveness of human instruction-guided speech generation and aligns the speech generation paradigm with other modalities. To enable the model to automatically extract the content of synthesized speech from raw text instructions, we introduce speech semantic tokens as an intermediate representation for instruction-to-content guidance. We also incorporate multiple Classifier-Free Guidance (CFG) strategies into our codec language model, which strengthens the generated speech following human instructions. Furthermore, our model architecture and training strategies allow for the simultaneous support of combining speech prompt and descriptive human instruction for expressive speech synthesis, which is a first-of-its-kind attempt. Codes, models and demos are at: https://github.com/thuhcsi/VoxInstruct.

Spoken Dialogue System for Medical Prescription Acquisition on Smartphone: Development, Corpus and Evaluation

Hospital information systems (HIS) have become an essential part of healthcare institutions and now incorporate prescribing support software. Prescription support software allows for structured information capture, which improves the safety, appropriateness and efficiency of prescriptions and reduces the number of adverse drug events (ADEs). However, such a system increases the amount of time physicians spend at a computer entering information instead of providing medical care. In addition, any new visiting clinician must learn to manage complex interfaces since each HIS has its own interfaces. In this paper, we present a natural language interface for e-prescribing software in the form of a spoken dialogue system accessible on a smartphone. This system allows prescribers to record their prescriptions verbally, a form of interaction closer to their usual practice. The system extracts the formal representation of the prescription ready to be checked by the prescribing software and uses the dialogue to request mandatory information, correct errors or warn of particular situations. Since, to the best of our knowledge, there is no existing voice-based prescription dialogue system, we present the system developed in a low-resource environment, focusing on dialogue modeling, semantic extraction and data augmentation. The system was evaluated in the wild with 55 participants. This evaluation showed that our system has an average prescription time of 66.15 seconds for physicians and 35.64 seconds for other experts, and a task success rate of 76\% for physicians and 72\% for other experts. All evaluation data were recorded and annotated to form PxCorpus, the first spoken drug prescription corpus that has been made fully available to the community (https://doi.org/10.5281/zenodo.6524162).

Text-driven Adaptation of Foundation Models for Few-shot Surgical Workflow Analysis

Purpose: Surgical workflow analysis is crucial for improving surgical efficiency and safety. However, previous studies rely heavily on large-scale annotated datasets, posing challenges in cost, scalability, and reliance on expert annotations. To address this, we propose Surg-FTDA (Few-shot Text-driven Adaptation), designed to handle various surgical workflow analysis tasks with minimal paired image-label data. Methods: Our approach has two key components. First, Few-shot selection-based modality alignment selects a small subset of images and aligns their embeddings with text embeddings from the downstream task, bridging the modality gap. Second, Text-driven adaptation leverages only text data to train a decoder, eliminating the need for paired image-text data. This decoder is then applied to aligned image embeddings, enabling image-related tasks without explicit image-text pairs. Results: We evaluate our approach to generative tasks (image captioning) and discriminative tasks (triplet recognition and phase recognition). Results show that Surg-FTDA outperforms baselines and generalizes well across downstream tasks. Conclusion: We propose a text-driven adaptation approach that mitigates the modality gap and handles multiple downstream tasks in surgical workflow analysis, with minimal reliance on large annotated datasets. The code and dataset will be released in https://github.com/CAMMA-public/Surg-FTDA

IndicLLMSuite: A Blueprint for Creating Pre-training and Fine-Tuning Datasets for Indian Languages

Despite the considerable advancements in English LLMs, the progress in building comparable models for other languages has been hindered due to the scarcity of tailored resources. Our work aims to bridge this divide by introducing an expansive suite of resources specifically designed for the development of Indic LLMs, covering 22 languages, containing a total of 251B tokens and 74.8M instruction-response pairs. Recognizing the importance of both data quality and quantity, our approach combines highly curated manually verified data, unverified yet valuable data, and synthetic data. We build a clean, open-source pipeline for curating pre-training data from diverse sources, including websites, PDFs, and videos, incorporating best practices for crawling, cleaning, flagging, and deduplication. For instruction-fine tuning, we amalgamate existing Indic datasets, translate/transliterate English datasets into Indian languages, and utilize LLaMa2 and Mixtral models to create conversations grounded in articles from Indian Wikipedia and Wikihow. Additionally, we address toxicity alignment by generating toxic prompts for multiple scenarios and then generate non-toxic responses by feeding these toxic prompts to an aligned LLaMa2 model. We hope that the datasets, tools, and resources released as a part of this work will not only propel the research and development of Indic LLMs but also establish an open-source blueprint for extending such efforts to other languages. The data and other artifacts created as part of this work are released with permissive licenses.

Language-Guided Music Recommendation for Video via Prompt Analogies

We propose a method to recommend music for an input video while allowing a user to guide music selection with free-form natural language. A key challenge of this problem setting is that existing music video datasets provide the needed (video, music) training pairs, but lack text descriptions of the music. This work addresses this challenge with the following three contributions. First, we propose a text-synthesis approach that relies on an analogy-based prompting procedure to generate natural language music descriptions from a large-scale language model (BLOOM-176B) given pre-trained music tagger outputs and a small number of human text descriptions. Second, we use these synthesized music descriptions to train a new trimodal model, which fuses text and video input representations to query music samples. For training, we introduce a text dropout regularization mechanism which we show is critical to model performance. Our model design allows for the retrieved music audio to agree with the two input modalities by matching visual style depicted in the video and musical genre, mood, or instrumentation described in the natural language query. Third, to evaluate our approach, we collect a testing dataset for our problem by annotating a subset of 4k clips from the YT8M-MusicVideo dataset with natural language music descriptions which we make publicly available. We show that our approach can match or exceed the performance of prior methods on video-to-music retrieval while significantly improving retrieval accuracy when using text guidance.

A Benchmark Dataset for Multimodal Prediction of Enzymatic Function Coupling DNA Sequences and Natural Language

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases linking DNA sequences to an enzymatic function label. However, much of the scientific community's knowledge of biological function is not represented in these categorical labels, and is instead captured in unstructured text descriptions of mechanisms, reactions, and enzyme behavior. These descriptions are often captured alongside DNA sequences in biological databases, albeit in an unstructured manner. Deep learning of models predicting enzymatic function are likely to benefit from incorporating this multi-modal data encoding scientific knowledge of biological function. There is, however, no dataset designed for machine learning algorithms to leverage this multi-modal information. Here we propose a novel dataset and benchmark suite that enables the exploration and development of large multi-modal neural network models on gene DNA sequences and natural language descriptions of gene function. We present baseline performance on benchmarks for both unsupervised and supervised tasks that demonstrate the difficulty of this modeling objective, while demonstrating the potential benefit of incorporating multi-modal data types in function prediction compared to DNA sequences alone. Our dataset is at: https://hoarfrost-lab.github.io/BioTalk/.

CNN based Cuneiform Sign Detection Learned from Annotated 3D Renderings and Mapped Photographs with Illumination Augmentation

Motivated by the challenges of the Digital Ancient Near Eastern Studies (DANES) community, we develop digital tools for processing cuneiform script being a 3D script imprinted into clay tablets used for more than three millennia and at least eight major languages. It consists of thousands of characters that have changed over time and space. Photographs are the most common representations usable for machine learning, while ink drawings are prone to interpretation. Best suited 3D datasets that are becoming available. We created and used the HeiCuBeDa and MaiCuBeDa datasets, which consist of around 500 annotated tablets. For our novel OCR-like approach to mixed image data, we provide an additional mapping tool for transferring annotations between 3D renderings and photographs. Our sign localization uses a RepPoints detector to predict the locations of characters as bounding boxes. We use image data from GigaMesh's MSII (curvature, see https://gigamesh.eu) based rendering, Phong-shaded 3D models, and photographs as well as illumination augmentation. The results show that using rendered 3D images for sign detection performs better than other work on photographs. In addition, our approach gives reasonably good results for photographs only, while it is best used for mixed datasets. More importantly, the Phong renderings, and especially the MSII renderings, improve the results on photographs, which is the largest dataset on a global scale.

Master-ASR: Achieving Multilingual Scalability and Low-Resource Adaptation in ASR with Modular Learning

Despite the impressive performance recently achieved by automatic speech recognition (ASR), we observe two primary challenges that hinder its broader applications: (1) The difficulty of introducing scalability into the model to support more languages with limited training, inference, and storage overhead; (2) The low-resource adaptation ability that enables effective low-resource adaptation while avoiding over-fitting and catastrophic forgetting issues. Inspired by recent findings, we hypothesize that we can address the above challenges with modules widely shared across languages. To this end, we propose an ASR framework, dubbed \METHODNS, that, for the first time, simultaneously achieves strong multilingual scalability and low-resource adaptation ability thanks to its modularize-then-assemble strategy. Specifically, \METHOD learns a small set of generalizable sub-modules and adaptively assembles them for different languages to reduce the multilingual overhead and enable effective knowledge transfer for low-resource adaptation. Extensive experiments and visualizations demonstrate that \METHOD can effectively discover language similarity and improve multilingual and low-resource ASR performance over state-of-the-art (SOTA) methods, e.g., under multilingual-ASR, our framework achieves a 0.13sim2.41 lower character error rate (CER) with 30\% smaller inference overhead over SOTA solutions on multilingual ASR and a comparable CER, with nearly 50 times fewer trainable parameters over SOTA solutions on low-resource tuning, respectively.

IryoNLP at MEDIQA-CORR 2024: Tackling the Medical Error Detection & Correction Task On the Shoulders of Medical Agents

In natural language processing applied to the clinical domain, utilizing large language models has emerged as a promising avenue for error detection and correction on clinical notes, a knowledge-intensive task for which annotated data is scarce. This paper presents MedReAct'N'MedReFlex, which leverages a suite of four LLM-based medical agents. The MedReAct agent initiates the process by observing, analyzing, and taking action, generating trajectories to guide the search to target a potential error in the clinical notes. Subsequently, the MedEval agent employs five evaluators to assess the targeted error and the proposed correction. In cases where MedReAct's actions prove insufficient, the MedReFlex agent intervenes, engaging in reflective analysis and proposing alternative strategies. Finally, the MedFinalParser agent formats the final output, preserving the original style while ensuring the integrity of the error correction process. One core component of our method is our RAG pipeline based on our ClinicalCorp corpora. Among other well-known sources containing clinical guidelines and information, we preprocess and release the open-source MedWiki dataset for clinical RAG application. Our results demonstrate the central role of our RAG approach with ClinicalCorp leveraged through the MedReAct'N'MedReFlex framework. It achieved the ninth rank on the MEDIQA-CORR 2024 final leaderboard.

Medical mT5: An Open-Source Multilingual Text-to-Text LLM for The Medical Domain

Research on language technology for the development of medical applications is currently a hot topic in Natural Language Understanding and Generation. Thus, a number of large language models (LLMs) have recently been adapted to the medical domain, so that they can be used as a tool for mediating in human-AI interaction. While these LLMs display competitive performance on automated medical texts benchmarks, they have been pre-trained and evaluated with a focus on a single language (English mostly). This is particularly true of text-to-text models, which typically require large amounts of domain-specific pre-training data, often not easily accessible for many languages. In this paper, we address these shortcomings by compiling, to the best of our knowledge, the largest multilingual corpus for the medical domain in four languages, namely English, French, Italian and Spanish. This new corpus has been used to train Medical mT5, the first open-source text-to-text multilingual model for the medical domain. Additionally, we present two new evaluation benchmarks for all four languages with the aim of facilitating multilingual research in this domain. A comprehensive evaluation shows that Medical mT5 outperforms both encoders and similarly sized text-to-text models for the Spanish, French, and Italian benchmarks, while being competitive with current state-of-the-art LLMs in English.

A Benchmark of Domain-Adapted Large Language Models for Generating Brief Hospital Course Summaries

Brief hospital course (BHC) summaries are common clinical documents generated by summarizing clinical notes. While large language models (LLMs) depict remarkable capabilities in automating real-world tasks, their capabilities for healthcare applications such as BHC synthesis have not been shown. To enable the adaptation of LLMs for BHC synthesis, we introduce a novel benchmark consisting of a pre-processed dataset extracted from MIMIC-IV notes, encapsulating clinical note, and brief hospital course (BHC) pairs. We assess the performance of two general-purpose LLMs and three healthcare-adapted LLMs to improve BHC synthesis from clinical notes. Using clinical notes as input for generating BHCs, we apply prompting-based (using in-context learning) and fine-tuning-based adaptation strategies to three open-source LLMs (Clinical-T5-Large, Llama2-13B, FLAN-UL2) and two proprietary LLMs (GPT-3.5, GPT-4). We quantitatively evaluate the performance of these LLMs across varying context-length inputs using conventional natural language similarity metrics. We further perform a qualitative study where five diverse clinicians blindly compare clinician-written BHCs and two LLM-generated BHCs for 30 samples across metrics of comprehensiveness, conciseness, factual correctness, and fluency. Overall, we present a new benchmark and pre-processed dataset for using LLMs in BHC synthesis from clinical notes. We observe high-quality summarization performance for both in-context proprietary and fine-tuned open-source LLMs using both quantitative metrics and a qualitative clinical reader study. We propose our work as a benchmark to motivate future works to adapt and assess the performance of LLMs in BHC synthesis.

Localising In-Domain Adaptation of Transformer-Based Biomedical Language Models

In the era of digital healthcare, the huge volumes of textual information generated every day in hospitals constitute an essential but underused asset that could be exploited with task-specific, fine-tuned biomedical language representation models, improving patient care and management. For such specialized domains, previous research has shown that fine-tuning models stemming from broad-coverage checkpoints can largely benefit additional training rounds over large-scale in-domain resources. However, these resources are often unreachable for less-resourced languages like Italian, preventing local medical institutions to employ in-domain adaptation. In order to reduce this gap, our work investigates two accessible approaches to derive biomedical language models in languages other than English, taking Italian as a concrete use-case: one based on neural machine translation of English resources, favoring quantity over quality; the other based on a high-grade, narrow-scoped corpus natively written in Italian, thus preferring quality over quantity. Our study shows that data quantity is a harder constraint than data quality for biomedical adaptation, but the concatenation of high-quality data can improve model performance even when dealing with relatively size-limited corpora. The models published from our investigations have the potential to unlock important research opportunities for Italian hospitals and academia. Finally, the set of lessons learned from the study constitutes valuable insights towards a solution to build biomedical language models that are generalizable to other less-resourced languages and different domain settings.

Instruct-Tuning Pretrained Causal Language Models for Ancient Greek Papyrology and Epigraphy

This article presents an experiment in fine-tuning a pretrained causal language model (Meta's Llama 3.1 8B Instruct) for aiding in three fundamental tasks of philological research: chronological and geographic attribution as well as text restoration in ancient Greek inscriptions and documentary papyri. Using a prompt-based instruct approach, the fine-tuned models surpass the state of the art in key metrics. For inscriptions, the models achieve a lower average character error rate (CER) of 22.5% (vs. 26.3%), while closely matching top-1 accuracy (60.9% vs. 61.8%) and top-20 accuracy (77.5% vs. 78.3%) for sequences up to 10 characters. They also provide a practical advantage by ignoring spaces during reconstruction, aligning better with the scriptio continua typically used in ancient written artifacts. In geographic attribution, the model outperforms previous benchmarks with a top-1 accuracy of 75.0% (vs. 70.8%) and a top-3 accuracy of 83.7% (vs. 82.1%). For dating, it achieves an average deviation of 26.2 years (vs. 29.3) and a median deviation of 1 year (vs. 3) from the actual date range. The models also set new baselines for documentary papyri, with a CER of 16.3%, a top-1 accuracy of 71.3%, and top-20 of 85.0% in text reconstruction; a top-1 accuracy of 66.4% and top-3 of 79.9% in geographic attribution; and, in chronological attribution, a deviation of 21.7 years from the actual termini post/ante quem, with a median deviation of 0 years.

Demo of the Linguistic Field Data Management and Analysis System -- LiFE

In the proposed demo, we will present a new software - Linguistic Field Data Management and Analysis System - LiFE (https://github.com/kmi-linguistics/life) - an open-source, web-based linguistic data management and analysis application that allows for systematic storage, management, sharing and usage of linguistic data collected from the field. The application allows users to store lexical items, sentences, paragraphs, audio-visual content with rich glossing / annotation; generate interactive and print dictionaries; and also train and use natural language processing tools and models for various purposes using this data. Since its a web-based application, it also allows for seamless collaboration among multiple persons and sharing the data, models, etc with each other. The system uses the Python-based Flask framework and MongoDB in the backend and HTML, CSS and Javascript at the frontend. The interface allows creation of multiple projects that could be shared with the other users. At the backend, the application stores the data in RDF format so as to allow its release as Linked Data over the web using semantic web technologies - as of now it makes use of the OntoLex-Lemon for storing the lexical data and Ligt for storing the interlinear glossed text and then internally linking it to the other linked lexicons and databases such as DBpedia and WordNet. Furthermore it provides support for training the NLP systems using scikit-learn and HuggingFace Transformers libraries as well as make use of any model trained using these libraries - while the user interface itself provides limited options for tuning the system, an externally-trained model could be easily incorporated within the application; similarly the dataset itself could be easily exported into a standard machine-readable format like JSON or CSV that could be consumed by other programs and pipelines.

ResumeFlow: An LLM-facilitated Pipeline for Personalized Resume Generation and Refinement

Crafting the ideal, job-specific resume is a challenging task for many job applicants, especially for early-career applicants. While it is highly recommended that applicants tailor their resume to the specific role they are applying for, manually tailoring resumes to job descriptions and role-specific requirements is often (1) extremely time-consuming, and (2) prone to human errors. Furthermore, performing such a tailoring step at scale while applying to several roles may result in a lack of quality of the edited resumes. To tackle this problem, in this demo paper, we propose ResumeFlow: a Large Language Model (LLM) aided tool that enables an end user to simply provide their detailed resume and the desired job posting, and obtain a personalized resume specifically tailored to that specific job posting in the matter of a few seconds. Our proposed pipeline leverages the language understanding and information extraction capabilities of state-of-the-art LLMs such as OpenAI's GPT-4 and Google's Gemini, in order to (1) extract details from a job description, (2) extract role-specific details from the user-provided resume, and then (3) use these to refine and generate a role-specific resume for the user. Our easy-to-use tool leverages the user-chosen LLM in a completely off-the-shelf manner, thus requiring no fine-tuning. We demonstrate the effectiveness of our tool via a video demo and propose novel task-specific evaluation metrics to control for alignment and hallucination. Our tool is available at https://job-aligned-resume.streamlit.app.

Salamandra Technical Report

This work introduces Salamandra, a suite of open-source decoder-only large language models available in three different sizes: 2, 7, and 40 billion parameters. The models were trained from scratch on highly multilingual data that comprises text in 35 European languages and code. Our carefully curated corpus is made exclusively from open-access data compiled from a wide variety of sources. Along with the base models, supplementary checkpoints that were fine-tuned on public-domain instruction data are also released for chat applications. Additionally, we also share our preliminary experiments on multimodality, which serve as proof-of-concept to showcase potential applications for the Salamandra family. Our extensive evaluations on multilingual benchmarks reveal that Salamandra has strong capabilities, achieving competitive performance when compared to similarly sized open-source models. We provide comprehensive evaluation results both on standard downstream tasks as well as key aspects related to bias and safety.With this technical report, we intend to promote open science by sharing all the details behind our design choices, data curation strategy and evaluation methodology. In addition to that, we deviate from the usual practice by making our training and evaluation scripts publicly accessible. We release all models under a permissive Apache 2.0 license in order to foster future research and facilitate commercial use, thereby contributing to the open-source ecosystem of large language models.