Business in Houston, MO The largest employers in Houston, MO include the Houston Public Schools, Texas County Memorial Hospital, and the Durham Company. Houston, MO also has the top numbers for beef and dairy cattle in Missouri. Agriculture is one of the areaâs biggest industriesâin addition to livestock, annual hay crops are a significant part of the townâs revenue. About Houston, MO. Located in the Ozarks, Houston, MO serves as the county seat of Texas county. With a population just over 2,000, Houston, MO is a small, close-knit community. The Houston School District has the highest accreditation available from Missouri, and is the largest district in the county. Go Tigers!