Tolerance can easily lead to addiction, which happens when your substance abuse begins to have a negative impact on your everyday activities yet you continue to seek out and abuse the drug. Long-term effects of hydrocodone use can include physical problems, such as hearing loss and liver damage.The most damaging result of being addicted to hydrocodone, however, may be its adverse effect on your personal life. Drug addiction can: 1  Wreak havoc on family relationships.2  Cause difficulties with job performance.3  Lead to mental health problems.he most damaging result of being addicted to hydrocodone, however, may be its adverse effect on your personal life. Drug addiction can: 1  Wreak havoc on family relationships. 2  Cause difficulties with job performance. 3  Lead to mental health problems.