Pain can also occur in the shoulder from diseases or conditions that involve the shoulder joint (including arthritis), the soft tissues and bones surrounding the shoulder, or the nerves that supply sensation to the shoulder area. Occasionally, shoulder pain can be a result of a heart attack.houlder pain can be a result of injury or disease of the shoulder joint. Injury can affect any of the ligaments, bursae, or tendons surrounding the shoulder joint. Injury can also affect the ligaments, cartilage, menisci (plural for meniscus), and bones of the joint.