âSixes and sevensâ as we use it today actually has two related but distinct meanings. When we say âIâm all sixes and sevensâ or the like, it means that we are confused, disoriented and uncertain, either in general or in regard to a specific problem.ut âsixes and sevensâ can also mean a state of irreconcilable conflict, usually preceded by âatâ (âBob and Bill were best friends, but the arrival of Mary set them at sixes and sevens for the whole summerâ).