1 Bilirubin levels may be elevated in the blood and urine. ' 2 Liver enzymes' can be measured in the blood â these are enzymes that are produced in liver cells and if there is damage to the liver (or perhaps obstruction to the flow of bile) these enzyme concentrations in the blood can become elevated.epending on the cause and severity, other signs such as a fever, increased thirst or vomiting may also be seen. In some cases liver disease may cause fluid to accumulate in the abdomen (ascites); and with more advanced or severe disease, jaundice (yellowing of the gums and skin) may be seen.