Genital human papillomavirus (or HPV) is the most common sexually transmitted disease (STD, commonly known as sexually transmitted infection, STI).Some types of genital HPV primarily infect skin near the genitals and anus.ome types of sexually transmitted HPV cause genital or anal warts. Warts appear as growths or bumps and may be raised or flat, single or multiple, small or large. They tend to be flesh-colored or whitish in appearance.