METHODS	In Study 2 , eligible participants were randomly assigned to treatment with pioglitazone 30 mg once daily ( QD ) alone for 8 days followed by concomitant pioglitazone and topiramate ( titrated to 96 mg BID ) from days 9 to 22 ( Group 1 ) or to topiramate ( titrated to 96 mg BID ) alone for 11 days followed by concomitant pioglitazone 30 mg QD and topiramate 96 mg BID from days 12 to 22 ( Group 2 ) .\