METHODS	Eight ( four men/four women ) patients underwent three study designs , each separated by a 1-week interval : study I , infusion of iloprost ( 3 ng kg ( -1 ) min ( -1 ) for 5 h ) for 1 day alone ( short-term treatment ) ; study II , infusion of saline ( for 5 h ) for 1 day ( control treatment ) ; study III , infusion of iloprost ( 3 ng kg ( -1 ) min ( -1 ) for 5 h ) over a period of 28 days ( long-term treatment ) .\