METHODS	Fourteen out-patients , 9 males and 5 females , aged 46-65 years ( mean + / - SD = 57 + / - 8 ) , with ischemic heart disease and reproducible ST-segment depression on two consecutive exercise stress tests in baseline conditions , underwent a study consisting of 4 periods : 1 and 3 placebo , 2 and 4 at random ISR ( 5 mg b.i.d. ) and DIL ( 120 mg b.i.d. ) .\