RESULTS	There was also a dose-dependent increase in FMD with oestradiol dose : at 1 month , - 0.2 , + 0.2 and + 1.8 % for groups 1-3 , respectively ( P = 0.31 by ANOVA for trend ) ; and at 6 months , - 0.8 , + 0.4 and + 2.2 % ( P = 0.02 ) .\