METHODS	In this prospective , randomized , single-blinded , placebo-controlled study , 180 children aged 1 to 5 years with a history of rAOM and previously unvaccinated against influenza were randomized to receive the inactivated virosomal-adjuvanted subunit influenza vaccine ( n = 90 ) or no treatment ( n = 90 ) , and AOM-related morbidity was monitored every 4 to 6 weeks for 6 months .\