RESULTS	GFJ significantly increased Cmax and AUC0-infinity of ( S ) - manidipine by 2.4-fold ( P < 0.01 ) and 2.3-fold ( P < 0.01 ) , respectively , and Cmax and AUC0-infinity of ( R ) - manidipine were increased by 3.4-fold ( P < 0.01 ) and 3.0-fold ( P < 0.01 ) , respectively .\