RESULTS	Cox 's proportional hazards regression models proved tumor budding to be an independent predictor of disease progression ( hazard ratio 3.91 , 95 % confidence interval 1.3-11 .77 ; P = 0.02 ) and cancer-related death ( hazard ratio 5.90 , 95 % confidence interval 1.62-21 .51 ; P = 0.007 ) .\