METHODS	C ( max ) and AUC ( last ) were determined from blood samples obtained at 0.33 , 0.67 , 1 , 1.5 , 2 , 3 , 4 , 6 , 8 , 12 , 24 , 48 , 72 , 96 , 120 , 168 , and 216 hours after drug administration .\