METHODS	We randomly assigned 375 patients with one to five ulcerative lesions from cutaneous leishmaniasis to receive a cream containing 15 % paromomycin-0 .5 % gentamicin ( called WR 279,396 ) , 15 % paromomycin alone , or vehicle control ( with the same base as the other two creams but containing neither paromomycin nor gentamicin ) .\