RESULTS	Comparison between the groups treated with placebo ( n = 30 ) and Nalpha-methylhistamine ( n = 30 ) , on data collected for the 4th , 8th and 12th weeks of treatment , revealed that Nalpha-methylhistamine exerted a significant ( p < 0.0001 ) reduction ( compared to placebo ) in intensity , frequency , and duration of migraine attacks , as well as on the use of analgesic intake .\