RESULTS	Comparing topotecan with BSC , infection grade 2 was 14 % versus 12 % and sepsis 4 % versus 1 % ; other grade 3/4 events included vomiting 3 % versus 0 , diarrhea 6 % versus 0 , dyspnea 3 % versus 9 % , and pain 3 % versus 6 % .\