RESULTS	Metformin ( but not placebo ) led to significant changes in circulating miR-192 ( 49.5 % ; P = 0.022 ) , miR-140-5p ( -15.8 % ; P = 0.004 ) , and miR-222 ( -47.2 % ; P = 0.03 ) , in parallel to decreased fasting glucose and HbA1c .\