METHODS	Patients who also meet dual target imaging criteria : vessel occlusion ( internal carotid or middle cerebral artery ) and mismatch ( perfusion lesion : ischemic core mismatch ratio > 12 , absolute mismatch > 10ml , ischemic core volume < 70ml ) will be randomized to either clot retrieval with the Solitaire FR device after full dose intravenous tissue plasminogen activator , or tissue plasminogen activator alone .\