RESULTS	The mean ( SD ) percentage changes of thyroxine-binding globulin , total T4 , and free T4 with oral CEE were +39.9 % ( 20.1 % ) , +28.4 % ( 29.2 % ) , and -10.4 % ( 22.3 % ) , respectively , versus +0.4 % ( 11.1 % ) , -0.7 % ( 16.5 % ) , and +0.2 % ( 26.6 % ) with TD E2 .\