RESULTS	Significantly greater least squares ( LS ) mean + / - SE changes in YMRS scores were observed on day 2 with asenapine ( -3.0 + / - 0.4 ) and olanzapine ( -3.4 + / - 0.4 ) versus placebo ( -1.5 + / - 0.5 , both p < 0.01 ) and were maintained until day 21 ( -10.8 + / - 0.8 with asenapine , -12.6 + / - 0.8 with olanzapine ; both p < or = 0.0001 versus placebo , -5.5 + / - 1.1 ) with LOCF .\