METHODS	Investigator-initiated , open-label , randomized clinical trial in 15 infants ( age range 77-257days ) with left-to-right shunt ( 11 out of 15 with additional trisomy 21 ) , and pulmonary hypertension ( i.e. mean pulmonary artery pressure [ PAP ] > 25mmHg ) after weaning from cardiopulmonary bypass .\