METHODS	In this prospective , randomized , open-label trial , hypertensive outpatients aged at least 65 years who had not achieved their target blood pressure ( BP ) with standard ARB dosages were randomly assigned to receive either a fixed-dose combination of losartan ( 50mg ) and hydrochlorothiazide ( 12.5 mg ) ( ARB+D ; n = 72 ) or a combination of amlodipine ( 5mg ) and the typical dosage of ARBs ( ARB+C ; n = 68 ) to evaluate the change in the BP , laboratory values and cognitive function .\