RESULTS	Compared with baseline , there was a greater reduction in malondialdehyde , nitrotyrosine , interleukin-6 , and endothelin-1 and a greater increase in flow-mediated dilation , coronary flow reserve , aortic distensibility , systolic velocity of mitral annulus , and E/Em after anakinra than after placebo ( malondialdehyde -25 % versus 9 % ; nitrotyrosine -38 % versus -11 % ; interleukin-6 -29 % versus 0.9 % ; endothelin-1 -36 % versus -11 % ; flow-mediated dilation 45 % versus -9 % ; coronary flow reserve 29 % versus 4 % ; and aortic distensibility 45 % versus 2 % ; P < 0.05 for all comparisons ) .\