METHODS	An analysis of variance was used to evaluate differences in pharmacokinetics with and without concomitant treatment ; 90 % confidence intervals ( CI ) for the ratio of the geometric least squares mean ( LSM ) estimates for maximum plasma concentration ( Cmax ) , area under concentration-time curve for dosing interval ( AUC12 or AUC24 ) , and oral clearance ( CL/F ) with and without concomitant treatment were used to assess a drug interaction .\