METHODS	Two hundred and twenty-six postmenopausal women were randomized to oral treatment for 48 weeks with 1 mg of 17beta-oestradiol per day continuously , plus 0.025 mg gestodene on days 17-28 of each 4-week cycle ( HRT 1 ) , or plus gestodene in each third cycle only ( HRT 2 ) , or no HRT .\