METHODS	Totally 314 critical patients , from eight comprehensive hospitals in Zhejiang Province admitted during January , 2005 to January , 2008 , suffering from severe sepsis/septic shock were randomized into conventional treatment group ( n = 151 ) and EGDT group ( n = 163 ) , the patients of the former underwent fluid resuscitation guided by central venous pressure ( CVP ) , systolic blood pressure ( SBP ) or mean artery pressure ( MAP ) and urinary output ( UO ) , and the latter guided by CVP , SBP or MAP and UO plus central venous oxygen saturation ( ScvO2 ) .\