METHODS	In a two-center , randomized , double-blind , comparative study 90 healthy postmenopausal women ( age 56.6 + / -4.7 years ) received daily continuous combined intranasal E2/NET 175 microg/275 microg ( n = 47 ) or oral E2/NETA 1 mg/0 .5 mg ( n = 43 ) for one year .\