RESULTS	After the 160 U insulin dose the blood glucose concentration ( mean + / - SE ) fell from 4.3 + / - 0.2 to 2.8 + / - 0.2 mmol L-1 ( P < 0.001 ) , concomitant with an increase in mean serum insulin concentrations , rising from 9.5 + / - 1.5 to 26.1 + / - 2.5 mU L-1 ( P < 0.001 ) .\