RESULTS	With lansoprazole 30 mg twice daily , the median of 24-h intragastric pH in poor metabolizers ( 6.1 ) was significantly higher than those of rapid extensive metabolizers ( 4.5 ) and intermediate metabolizers ( 5.0 ) , respectively ( P = 0.0176 and 0.0388 ) , whereas with lansoprazole 30 mg twice and famotidine 20 mg twice daily , the medians were 5.4 , 5.7 , and 6.1 , respectively ( not significant ) .\