METHODS	Relative rates ( RRs ) of detection to assess test sensitivity , specificity , and positive predictive values ( PPVs ) with 95 % confidence intervals ( CIs ) were calculated for the histological endpoints of cervical intraepithelial neoplasia ( CIN ) grade 1 or higher ( CIN 1 + ) , CIN grade 2 or higher ( CIN 2 + ) , and CIN grade 3 or higher ( CIN 3 + ) .\