METHODS	Examination at baseline and after 6 months of therapy included 6 min walk test , treadmillometry with assessment of maximal oxygen consumptiion ( VO2max ) , echocardiography , 24 hour blood pressure monitoring , measurement of N-terminal precursor of brain natriuretic peptide ( NT-proBNP ) ; test of cardio-respiratory synchronism was used for objective qualitative determination of the state of the , renin-angiotensin system .\