METHODS	All individuals received each of 4 regimens successively , separated by a 4-day washout period : a single IV dose of rosiglitazone 2 mg administered alone over 1 hour ; a single IV dose of rosiglitazone 2 mg administered over 1 hour on the fourth day of treatment with oral ranitidine 150 mg given every 12 hours ; a single oral dose of rosiglitazone 4 mg alone ; and a single oral dose of rosiglitazone 4 mg on the fourth day of treatment with oral ranitidine 150 mg given every 12 hours .\