RESULTS	At days 2 , 4 and 7 there was no significant change in mean LDL-C levels in the NLLD group ( -10 % , -6 % , and -9 % , all P > 0.09 ) , while there were significant reductions with SIMVA ( -15 % , -27 % , and -25 % , respectively , all P < 0.001 vs. day 0 ) and even greater reductions with co-administration of EZE/SIMVA ( -27 % , -41 % , and -51 % , respectively , all P < 0.001 vs. day 0 ) .\