OBJECTIVE	We hypothesized that anterior circulation ischemic stroke patients , selected with ` dual target ' vessel occlusion and evidence of salvageable brain using computed tomography or magnetic resonance imaging ` mismatch ' within 45h of onset , would have improved reperfusion and early neurological improvement when treated with intra-arterial clot retrieval after intravenous tissue plasminogen activator compared with intravenous tissue plasminogen activator alone .\