RESULTS	However , there was a statistically significant reduction in average TBR in active segments ( TBR 1.6 ) ( HD vs. placebo : TBR : -0.10 [ 95 % CI : -0.19 to -0.02 ] , p = 0.0125 ; LD vs. placebo : TBR : -0.10 [ 95 % CI : -0.18 to -0.02 ] , p = 0.0194 ) .\