BACKGROUND	In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ( ALLHAT ) , a randomized , double-blind , practice-based , active-control , comparative effectiveness trial in high-risk hypertensive participants , risk of new-onset heart failure ( HF ) was higher in the amlodipine ( 2.5-10 mg/d ) and lisinopril ( 10-40 mg/d ) arms compared with the chlorthalidone ( 12.5-25 mg/d ) arm .\