RESULTS	The median lesion and shedding rates were lower for resiquimod compared with vehicle recipients during the initial sampling period ( 10 % vs. 16 % [ P = .03 ] and 10 % vs. 17 % [ P = .08 ] , respectively ) and during the final sampling period ( 3 % vs. 22 % [ P < .001 ] and 10 % vs. 26 % [ P = .009 ] , respectively ) .\