BACKGROUND	We evaluated the hypothesis that in patients with chronic heart failure ( CHF ) and activated cardiac renin-angiotensin-aldosterone system ( RAAS ) , lipophilic ACE inhibitors with high affinity for ACE ( perindopril and quinapril ) will cause marked blockade of cardiac angiotensin ( Ang ) II and aldosterone generation , but not a hydrophilic ACE inhibitor with low affinity for ACE ( lisinopril ) .\