RESULTS	Following co-administration with fluconazole , rosuvastatin geometric least-square mean area under the plasma concentration-time curve ( AUC ( 0-t ) ) and peak plasma concentration ( C ( max ) ) were increased by 14 % and 9 % , respectively , compared with placebo ( 90 % confidence intervals for the treatment ratios : 0.967 to 1.341 and 0.874 to 1.355 , respectively ) .\