RESULTS	The subsequent injection of rVIIa ( 90 microgram/kg ) resulted in an immediate and complete correction of the prothrombin time and a marked generation of thrombin , reflected by increased levels of prothrombin activation fragment F1 +2 and thrombin-antithrombin complexes from 0.75 + / -0.64 to 3.29 + / -6.3 nmol/L and from 2.4 + / -0.6 to 10.7 + / -3.9 microgram/mL , respectively .\