METHODS	Forty adults of mean age 37 years with moderate asthma ( mean ( SE ) forced expiratory volume in one second ( FEV1 ) 73.6 ( 1.4 ) % predicted , mean morning peak expiratory flow ( PEF ) 328 l/min ) were randomised to receive either a twice daily dose ( 400 micrograms morning and bedtime ) of inhaled budesonide ( group A ) or a once daily dose of 800 micrograms ( group B ) and were followed for a period of 12 months .\