OBJECTIVE	The effect of pamidronate on markers of bone resorption [ cross-linked N-telopeptides of type I collagen ( NTx ) ] , markers of bone formation [ serum alkaline phosphatase ( BAP ) and osteocalcin ( OSC ) ] , interleukin-6 ( IL-6 ) , beta2-microglobulin , CRP , paraprotein and disease-related pain and skeletal events has been evaluated in 62 newly diagnosed patients with MM .\