RESULTS	Using an intention-to-treat approach we found no observed difference in time to virological failure between the allocation groups : failures in the intervention and standard care arms were 49/315 ( 15.6 % ) and 49/316 ( 15.5 % ) respectively ( unadjusted hazard ratio 0.98 , 95 % confidence interval 0.67 to 1.47 , P = 0.95 ) .\