METHODS	Chemotherapy was given for a period of 2 years and consisted of monthly courses of cyclophosphamide 50 mg/m2 orally on days 1 to 14 , methotrexate 15 mg/m2 intravenously on days 1 and 8 , and fluorouracil 350 mg/m2 intravenously on days 1 and 8 ( CMF ) .\