RESULTS	day-1 , the pharmacokinetic parameters were determined after the first i.v. administration of 1 g.m-2 ( bolus dose of 0.2 g.m-2 followed by an 8-h infusion of 0.8 g.m-2 ) in 11 patients : systemic clearance was 23.02 1.h-1 , volume of distribution was 0.75 l.kg-1 , and elimination half-life was 1.64 h.\