METHODS	In a double-blind trial involving patients with end-stage renal disease who were receiving hemodialysis , we evaluated the safety , immunogenicity , and efficacy of a vaccine with S. aureus type 5 and 8 capsular polysaccharides conjugated to nontoxic recombinant Pseudomonas aeruginosa exotoxin A. Between April 1998 and August 1999 , 1804 adult patients at 73 hemodialysis centers were randomly assigned to receive a single intramuscular injection of either vaccine or saline .\