METHODS	Concentrations in plasma of interleukin 6 ( IL-6 ) , IL-8 , IL-10 , free methylprednisolone and total methylprednisolone were obtained for the following : ( 1 ) at anesthesia induction before the study drug was administered ; ( 2 ) 30 minutes on cardiopulmonary bypass ; ( 3 ) 5 minutes after protamine administration ; and ( 4 ) 6 hours after weaning from cardiopulmonary bypass .\