METHODS	Participants were assigned to receive alprazolam or placebo as follows : cycle 1 , 0.25 mg of alprazolam or placebo three times daily beginning on menstrual cycle day 16 ; cycle 2 , 0.50 mg of alprazolam or placebo three times daily according to the regimen during the first cycle ; cycles 3 and 4 , 0.75 mg of alprazolam or placebo three times daily from menstrual cycle day 16 and continued throughout the fourth menstrual cycle to evaluate the efficacy of relatively long-term ( approximately 6 weeks ) treatment with alprazolam .\