METHODS	The association of 10 circulating miRNAs with T2D was cross-sectionally validated in an extended sample of 45 NGT vs. 48 T2D subjects ( 65 nonobese and 28 obese men ) and longitudinally in 35 T2D patients who were recruited in a randomized , double-blinded , and placebo-controlled 3-month trial of metformin treatment .\