METHODS	We studied 22 healthy male smokers ( mean + / - SD , 23 + / - 9 cigarettes per day ) randomly assigned to receive either 600 IU vitamin E per day ( n = 11 , age 28 + / - 6 years ) or placebo ( n = 11 , age 27 + / - 6 years ) for four weeks and 11 age-matched healthy male nonsmokers .\