METHODS	Women ( n = 1108 ) were randomly assigned to 1 of 6 intervention groups for which daily intakes of folic acid for 6 mo were 100 microg 1 time/d , 25 microg 4 times/d , 400 microg 1 time/d , 100 microg 4 times/d , 4000 microg 1 time/d , or 4000 microg 1 time/wk .\