RESULTS	Physical activity was higher during the HOA than during the HPA in 15 of 17 subjects in cohort 1 ( P = 0.008 ) ( mean : 12 % higher ; P = 0.003 ) and in 12 of 12 subjects in the second , confirmatory cohort ( P = 0.005 ) ( mean : 15 % higher ; P = 0.003 ) .\