RESULTS	Compared with placebo , 0.5 mg of lasofoxifene statistically significantly reduced the risk of total breast cancer by 79 % ( hazard ratio = 0.21 ; 95 % confidence interval [ CI ] = 0.08 to 0.55 ) and ER + invasive breast cancer by 83 % ( hazard ratio = 0.17 ; 95 % CI = 0.05 to 0.57 ) .\