METHODS	In a double-blind , randomized , controlled , and multicenter trial in Germany , 270 patients with an H. pylori-associated duodenal ulcer were treated with 40 mg omeprazole three times a day and 750 mg amoxicillin three times a day for the first 14 days ( n = 139 ) followed by 20 mg omeprazole once daily until day 42 or with omeprazole plus 750 mg amoxicillin placebo three times a day for the same time period ( n = 131 ) .\