RESULTS	There were no differences in beta2-adrenoceptor density ( Bmax ) between the three treatments prior to the first dose ; whereas , after the last dose , Bmax was lower with both active treatments than with placebo , but was significant for salmeterol only -- a 1.2-fold geometric mean fold difference ( 95 % CI 1 - to 1.4-fold ) , P = 0.04 .\