RESULTS	Episodes of deterioration in renal function ( change in serum creatinine > or = 20 % ) were categorized with the following results for CsA-ME versus CsA , respectively : acute rejection , 4.5 % vs. 4.5 % ; chronic rejection , 8 % vs. 11 % ; CsA nephrotoxicity , 12 % vs. 7 % ( P = 0.008 ) ; transient changes , 17 % vs. 12 % ; other causes , 4 % vs. 6 % .\