RESULTS	The contents of bone gla protein ( BGP ) , calcitonin ( CT ) , parathyroid hormone ( PTH ) and alkaline phosphatase ( AKP ) in the both groups had significant differences after treatment ( P < 0.05 , P < 0.01 ) ; 2 ) The content of estradiol ( E2 ) in serum in the both groups was decreased more obviously than those of normal women in reproductive age ( both P < 0.001 ) .\