METHODS	From March 1990 through October 1999 , 1063 patients stratified by estrogen receptor ( ER ) status and radiotherapy plan were randomly assigned to receive goserelin for 24 months ( n = 346 ) , six courses of `` classical '' CMF ( cyclophosphamide , methotrexate , 5-fluorouracil ) chemotherapy ( n = 360 ) , or six courses of classical CMF followed by 18 months of goserelin ( CMF -- > goserelin ; n = 357 ) .\