RESULTS	All EREM dosages reduced the mean ( + / - SD ) fentanyl use versus placebo ( 510 + / - 708 vs. 2,091 + / - 1,803 microg ; P < 0.0001 ) and delayed the median time to first dose of fentanyl ( 21.3 vs. 3.6 h ; P < 0.0001 ) .\