METHODS	Heart and respiratory rate , rectal temperature , indirect blood pressure , and mechanical threshold were measured , and sedation and posture were scored and blood samples obtained to measure epinephrine , norepinephrine , free fatty acids , glucose , and cortisol concentrations at baseline ( immediately before medetomidine ) , 5 and 25 minutes after medetomidine administration , and at 5 , 30 , 60 , and 120 minutes after the administration of antagonist or saline .\