METHODS	An open , randomized trial was conducted to test for equivalence between the standard melarsoprol regimen and 3 other regimens , as follows : standard melarsoprol therapy ( 3 series of 3.6 mg/kg/day intravenously [ iv ] for 3 days , with 7-day breaks between the series ) ; 10-day incremental-dose melarsoprol therapy ( 0.6 mg/kg iv on day 1 , 1.2 mg/kg iv on day 2 , and 1.8 mg/kg iv on days 3-10 ) ; nifurtimox monotherapy for 14 days ( 5 mg/kg orally 3 times per day ) ; and consecutive 10-day melarsoprol-nifurtimox combination therapy ( 0.6 mg/kg iv melarsoprol on day 1 , 1.2 mg/kg iv melarsoprol on day 2 , and 1.2 mg/kg/day iv melarsoprol combined with oral 7.5 mg/kg nifurtimox twice a day on days 3-10 ) .\