RESULTS	Among the mITT population , SPID24 ( using nonimputed data after first rescue : 1000 mg q6h , P < 0.001 ; 650 mg q4h , P = 0.020 ) , sum of PR scores over 24 hours ( 1000 mg q6h , P < 0.001 ; 650 mg q4h , P = 0.003 ) and 12 hours ( 1000 mg q6h , P < 0.001 ; 650 mg q4h , P = 0.001 ) , and subjects ' global evaluations at 24 hours ( 1000 mg q6h , P < 0.001 ; 650 mg q4h , P = 0.005 ) were statistically significant in favor of both acetaminophen dosing regimens compared with the combined placebo group .\