METHODS	Sixty-six American Society of Anesthesiologists I and II adult patients , 18 to 50 years , undergoing elective tumor decompression were recruited into this prospective , randomized , double-blind , placebo controlled study , and scheduled to receive either oral pantoprazole 40 mg ( placebo group ) or oral clonidine 3 microg/kg ( clonidine group ) , 90 minutes before induction of anesthesia .\