RESULTS	Prothrombin fragment F1 .2 , thrombin-antithrombin complex , and D-dimer increased after surgery and were persistently higher than preoperative values as late as 30 postoperative days in both on - and off-pump groups ; higher levels of these variables were detected after on-pump surgery relative to off-pump surgery only at the time point after termination of cardiopulmonary bypass ( fragment F1 .2 and thrombin-antithrombin complex ) or from bypass end to 8 postoperative days ( D-dimer ) .\