METHODS	Efficacy variables included change from baseline in the 17-item Hamilton Rating Scale for Depression ( HAM-D ( 17 ) , the primary efficacy measure ) , Clinical Global Impressions-Improvement scale ( CGI-I ) , Montgomery-Asberg Depression Rating Scale , Clinical Global Impressions-Severity of Illness scale ( CGI-S ) , rates of response ( > or = 50 % decrease from baseline HAM-D ( 17 ) score ) and remission ( HAM-D ( 17 ) score < or = 7 ) , and Visual Analog Scale-Pain Intensity overall score .\