METHODS	Eighty subjects , aged 50 years and older , with major depressive episodes that began within 6 months before or 12 months after the loss of a spouse or significant other were randomly assigned to a 16-week doubleblind trial of one of four treatment conditions : nortriptyline plus interpersonal psychotherapy ( N = 16 ) , nortriptyline alone in a medication clinic ( N = 25 ) , placebo plus interpersonal psychotherapy ( N = 17 ) , or placebo alone in a medication clinic ( N = 22 ) .\