RESULTS	The rate of clinical failure -- defined as the persistence of signs of acute infection on otoscopic examination -- was also lower among the children treated with amoxicillin-clavulanate than among those who received placebo : 4 % versus 23 % at or before the visit on day 4 or 5 ( P < 0.001 ) and 16 % versus 51 % at or before the visit on day 10 to 12 ( P < 0.001 ) .\