RESULTS	In the unplanned subset analysis limited to patients who had microscopically involved resection margins and/or extracapsular spread of disease , local-regional failure occurred in 33.1 % vs 21.0 % ( P = .02 ) , disease-free survival was 12.3 % vs 18.4 % ( P = .05 ) , and overall survival was 19.6 % vs 27.1 % ( P = .07 ) , respectively .\