RESULTS	Mean treatment effects for pain severity ( mean change from baseline in the enzalutamide group -015 , 95 % CI -028 to -002 , vs placebo 050 , 029 to 070 ; difference -065 , 95 % CI -089 to -041 ; p < 00001 ) and interference ( -001 , -018 to 016 , vs 074 , 047 to 100 ; respectively , difference -074 , 95 % -106 to -043 ; p < 00001 ) were significantly better with enzalutamide than with placebo .\