RESULTS	At the IT , systolic blood pressure increased ( p = 0.02 ) , from 180 + / - 19 mm Hg to 187 + / - 15 mm Hg ( ISR ) and 191 + / - 15 mm Hg ( DIL ) ; similarly , heart rate increased from 133 + / - 24 bpm to 144 + / - 18 bpm ( ISR : p = 0.002 ) and 140 + / - 17 bpm ( DIL : p = NS ) .\