METHODS	Obese adults ( n = 115 , BMI 34.4 4.2 kg/m ( 2 ) , age 58 7 years ) with T2DM were randomized to a hypocaloric LC diet ( 14 % carbohydrate [ < 50 g/day ] , 28 % protein , and 58 % fat [ < 10 % saturated fat ] ) or an energy-matched HC diet ( 53 % carbohydrate , 17 % protein , and 30 % fat [ < 10 % saturated fat ] ) combined with structured exercise for 24 weeks .\