CREATE TABLE medicine (id NUMBER, name CLOB, trade_name CLOB, fda_approved CLOB)
CREATE TABLE medicine_enzyme_interaction (enzyme_id NUMBER, medicine_id NUMBER, interaction_type CLOB)
CREATE TABLE enzyme (id NUMBER, name CLOB, location CLOB, product CLOB, chromosome CLOB, omim NUMBER, porphyria CLOB)

What are the medicine and trade names that cannot interact with the enzyme with the product 'Heme'?
SELECT name, trade_name FROM medicine EXCEPT SELECT T1.name, T1.trade_name FROM medicine AS T1 JOIN medicine_enzyme_interaction AS T2 ON T2.medicine_id = T1.id JOIN enzyme AS T3 ON T3.id = T2.enzyme_id WHERE T3.product = 'Protoporphyrinogen IX'
SELECT "name", "trade_name" FROM "medicine" EXCEPT SELECT "T1"."name", "T1"."trade_name" FROM "medicine" "T1" JOIN "medicine_enzyme_interaction" "T2" ON "T1"."id" = "T2"."medicine_id" JOIN "enzyme" "T3" ON "T2"."enzyme_id" = "T3"."id" AND "T3"."product" = 'Protoporphyrinogen IX'