CREATE TABLE table_16099 ("No. in series" FLOAT, "No. in season" FLOAT, "Title" CLOB, "Setting" CLOB, "Directed by" CLOB, "Written by" CLOB, "U.S. viewers  ( million ) " CLOB, "Original air date" CLOB)

What was the original air date of an episode set in 1544?
SELECT "Original air date" FROM table_16099 WHERE "Setting" = '1544'
SELECT "Original air date" FROM "table_16099" WHERE "Setting" = '1544'