CREATE TABLE medicine (id NUMBER, name CLOB, trade_name CLOB, fda_approved CLOB)
CREATE TABLE medicine_enzyme_interaction (enzyme_id NUMBER, medicine_id NUMBER, interaction_type CLOB)
CREATE TABLE enzyme (id NUMBER, name CLOB, location CLOB, product CLOB, chromosome CLOB, omim NUMBER, porphyria CLOB)

How many medicines were not approved by the FDA?
SELECT COUNT(*) FROM medicine WHERE fda_approved = 'No'
SELECT COUNT(*) FROM "medicine" WHERE "fda_approved" = 'No'