CREATE TABLE table_22224 ("Enzyme" CLOB, "Location" CLOB, "Substrate" CLOB, "Product" CLOB, "Chromosome" CLOB, "EC" CLOB, "OMIM" FLOAT, "Porphyria" CLOB)

give the location of subtrate coproporphyrinogen iii
SELECT "Location" FROM table_22224 WHERE "Substrate" = 'Coproporphyrinogen III'
SELECT "Location" FROM "table_22224" WHERE "Substrate" = 'Coproporphyrinogen III'