CREATE TABLE table_1226 ("Round #" FLOAT, "Pick #" FLOAT, "Player" CLOB, "Position" CLOB, "College" CLOB)

Who was the highest picked defensive end
SELECT MAX("Pick #") FROM table_1226 WHERE "Position" = 'Defensive end'
SELECT MAX("Pick #") FROM "table_1226" WHERE "Position" = 'Defensive end'