CREATE TABLE enzyme (id NUMBER, name CLOB, location CLOB, product CLOB, chromosome CLOB, omim NUMBER, porphyria CLOB)
CREATE TABLE medicine (id NUMBER, name CLOB, trade_name CLOB, fda_approved CLOB)
CREATE TABLE medicine_enzyme_interaction (enzyme_id NUMBER, medicine_id NUMBER, interaction_type CLOB)

What is the count of enzymes without any interactions?
SELECT COUNT(*) FROM enzyme WHERE NOT id IN (SELECT enzyme_id FROM medicine_enzyme_interaction)
SELECT COUNT(*) FROM "enzyme" WHERE NOT "id" IN (SELECT "enzyme_id" FROM "medicine_enzyme_interaction")