caption: In yeast studies A simple DNA sequence of approximately 125 bp is sufficient to serve as a centromere in this organism.
exif: {"Image DocumentName": "In yeast studies A simple DNA sequence of approximately 125 bp is sufficient to serve as a centromere in this organism.", "Image ImageDescription": "Despite its small size, more than a dozen different proteins assemble on this DNA sequence. The proteins include a histone H3 variant that, along with the other core histones, is believed to form a centromere-specific nucleosome. Figure The specialized nucleosome formed on centromeres. (A) A model for the proteins that assemble on a yeast centromere. The specialized nucleosome contains an H3 variant (called CENP-A in most organisms), along with core histones H2A, H2B, and H4. The folding of DNA into this nucleosome facilitates the assembly of the other centromere-binding proteins, which form the kinetochore that attaches the centromere to the mitotic spindle (B) The localization of conventional histone H3 on Drosophila mitotic chromosomes. The conventional H3 has been fused to a fluorescent protein and appears green. A component of the kinetochore has been stained red with antibodies against a specific kinetochore protein. (C) The same experiment, but with the centromere-specific histone H3 (instead of the conventional H3) labeled green. When the red and green stains are coincident, the staining appears yellow. (A, adapted from P.B. Meluh et al., Cell 94: , 1998; B and C, from S. Henikoff et al., Proc. Natl. Acad. Sci. USA 97: , \u00a9 National Academy of Sciences.)", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}