exhibit 10. 1 amendment n1 to master service agreement dated august 16, 2010 by and between adherex technologies, inc. and oct group, llc new york april 2, 2011 new york april 2, 2011 new york april 2, 2011 april 2, 2011 adherex technologies, inc., having its registered office at 501 eastowne drive, suite 140, chapel hill, nc 27514, usa ( hereinafter referred to as " adherex " ), on the one side, in person of the ceo rosty raykov, and oct group, llc, having its principal office at 845 third avenue, 6th floor, new york, ny, 10022, usa, hereinafter referred to as ‘ ’ oct ’ ’, in person of the president dmitry sharov, on the other side, collectively referred to as “ parties ”, concluded this amendment to the master service agreement dated august 16, 2010 ( msa ) together with its exhibit 1. - psa dd. aug. 16, 2010, due to the changes in the scope of services required by adherex from oct. the parties agree on the following : 1. adherex requires and oct agrees to perform following additional services : 1. 1. 1. 1. open 2 ( two ) additional sites for its clinical trial, carried in russia by oct ; 1. 1. 1. 1. 1. 2. perform safety activities for the clinical trial ; 1. 2. 1. 2. 2. msa dated august 16, 2010 shall be amended by adding exhibit 2 psa “ additional services budget ” dated march 09, 2011 enclosed hereto. 2. 2. 3. the total cost of the services listed in article 1 above and ptcs associated with services is 150. 078, 00 ( one hundred fifty thousand seventy eight ) usd as detailed in exhibit 2 psa “ additional services budget ” dated march 09, 2011. 3. 3. 4. exhibit 1 psa dd. aug. 16, 2010 shall be amended as follows : 4. 4. 4. 1. section warehouse of exhibit 1 psa dated aug. 16, 2010 shall be considered null and void by the parties as of march 09, 2011 and shall be replaced in full by section vendor warehouse dd. march 09, 2011 attached hereto. 4. 1. 4. 1. 5. the parties agree on the following invoicing procedure for the additional services stipulated in article 1 above : 5