exhibit 10. 3 amendment no. 1 the license agreement between brookhaven science associates llc. and catalyst pharmaceutical partners, inc., effective as of april 3, 2006, is hereby amended, effective april 3, 2006 as follows : in article i — definitions, sub - paragraph 12 of paragraph ( a ), “ patent rights ”, is replaced in its entirety as follows : 12. foreign patents and foreign patent applications corresponding to u. s. patents and patent applications identified in paragraph 1 — 11 above. in article xiii — notices, paragraph ( a ), the contact information for licensor is replaced as follows : for licensor : christine brakel, licensing specialist office of intellectual property and sponsored research brookhaven national laboratory building no. 475d p. o. box 5000 upton, new york # # # - # # # - # # # # telephone : 631 # # # - # # # - # # # # fax : 631 # # # - # # # - # # # # e - mail : * * * @ * * * in article xiii — notices, paragraph ( b ), the delivery details for mailing checks is replaced as follows : check mailed to : manager office of intellectual property and sponsored research brookhaven national laboratory bldg. 475d, p. o. box 5000 upton, ny # # # - # # # - # # # # 1 exhibit 10. 3 amendment no. 1 the license agreement between brookhaven science associates llc. and catalyst pharmaceutical partners, inc., effective as of april 3, 2006, is hereby amended, effective april 3, 2006 as follows : in article i — definitions, sub - paragraph 12 of paragraph ( a ), “ patent rights ”, is replaced in its entirety as follows : 12. foreign patents and foreign patent applications corresponding to u. s. patents and patent applications identified in paragraph 1 — 11 above. in article xiii — notices, paragraph ( a ), the contact information for licensor is replaced as follows : for licensor : christine brakel, licensing specialist office of intellectual property and sponsored research brookhaven national laboratory building no. 475d p. o. box 5000 upton, new york # # # - # # # - # # # # telephone : 631 # # # - # # # - # # # # fax : 631 # # # - # # # - # # # # e - mail :