exhibit 10. 3 october 1, 2008 martha b. steinbock cc : robert j. griesbach usda - ars - ott 5601 sunnyside avenue beltsville, md 20705 - 5131 re : termination of crada 58 - 3k95 - 8 - 1238 dear mrs. steinbock, according to article 13 of our cooperative research and development agreement 58 - 3k95 - 8 - 1238 between usda / ars and hepalife biosystems, inc., herewith we provide written notice to terminate the agreement effective november 30, 2008. we would like to thank you for the very fruitful r & d cooperation over the last years. please do not hesitate to contact me if there are further questions. sincerely, hepalife biosystems, inc / s / frank menzler frank menzler chief executive officer