exhibit 10. 1 december 11, 2018 via facsimile 646 # # # - # # # - # # # # mr. george santana managing director, investment banking chardan capital markets, llc 17 state street, suite 1600 new york, ny 10004 re : notice of termination of equity distribution agreement re : notice of termination of equity distribution agreement re : notice of termination of equity distribution agreement dear george : pursuant to section 11 ( b ) of the equity distribution agreement by and between chardan capital markets, llc ( “ chardan ” ) and hemispherx biopharma, inc. ( the “ company ” ) dated december 15, 2015 ( the “ eda ” ), the company hereby notifies chardan that it is terminating the eda effective december 11, 2018, and chardan has waived the contract ten ( 10 ) day notice. sincerely, / s / thomas k equels thomas k. equels, ceo sincerely, sincerely, / s / thomas k equels / s / thomas k equels thomas k. equels, ceo thomas k. equels, ceo cc : anthony j. marsico, esq. mintz levin cohn ferris glovsky and popeo pc chrysler center 666 third avenue new york, ny 10017 cc : anthony j. marsico, esq. cc : anthony j. marsico, esq. mintz levin cohn ferris glovsky and popeo pc mintz levin cohn ferris glovsky and popeo pc chrysler center chrysler center 666 third avenue 666 third avenue new york, ny 10017 new york, ny 10017 corporate headquarters 2117 sw highway 484, ocala fl 34473 t : 407 # # # - # # # - # # # # f : 407 # # # - # # # - # # # # finance & administration 600 main street, suite 2, riverton nj 08077 t : 215 # # # - # # # - # # # # f : 215 # # # - # # # - # # # # manufacturing 783 jersey ave, new brunswick, nj 08901 www. hemispherx. net t : 732 # # # - # # # - # # # # f : 732 # # # - # # # - # # # # corporate headquarters corporate headquarters 2117 sw highway 484, ocala fl 34473 t