exhibit 10. 1 second amendment to license agreement relating to encapsulated cells producing viral particles and encapsulated cells expressing biomolecules licensors bavarian nordic a / s, reg. no. 16271187 a company incorporated in denmark, whose registered office is at hejreskovvej 10a, dk - 3490 kvistgard, dennmark and helmholtz zentrum miinchen / gsf — forschungszentrum fur umwelt u. gesundheit gmbh, ingolstadter landstr. 1, d - 85764 neuherberg, deutschland and licensee bio blue bird ag, pflugstr. 7, fl - 9490 vaduz, liechtenstein this second amendment to licensee agreement ( " second amendment " ) is made effective as of the 1st day of october 2016 ( " effective date of the second amendment " ) between : ( 1 ) bavarian nordic a / s, reg. no. 16271187, a company incorporated in denmark, whose registered office is at hejreskovvej 10a, dk - 3490 kvistgard, denmark ( " bavarian nordic " ) and ( 2 ) helmholtz zentrum munchen / gsf - forschungszentrum fur umwelt u. gesundheit gmbh, ingolstadter landstr. 1, d - 85764 neuherberg, deutschland ( " gsf " ) ( bavarian nordic and gsf jointly referred to as " licensors " ) and ( 3 ) bio blue bird ag, pflugstr. 7, fl - 9490 vaduz, liechtenstein ( " licensee " ). ( 1 ) bavarian nordic a / s, reg. no. 16271187, a company incorporated in denmark, whose registered office is at hejreskovvej 10a, dk - 3490 kvistgard, denmark ( " bavarian nordic " ) and ( 1 ) ( 2 ) helmholtz zentrum munchen / gsf - forschungszentrum fur umwelt u. gesundheit gmbh, ingolstadter landstr. 1, d - 85764 neuherberg, deutschland ( " gsf " ) ( bavarian nordic and gsf jointly referred to as " licensors " ) and ( 2 ) ( 3 ) bio blue bird ag