exhibit 10. 45 amended and restated sales force work order # 8795 and termination of work order # 8872 effective date : january 26, 2004 this amended and restated sales force work order is entered into between columbia laboratories, inc., ( “ columbia ” ) and innovex inc. ( “ innovex ” ), pursuant to the master services agreement, having an effective date of july 31, 2002, between columbia and innovex ’ s predecessor, innovex lp, and is subject to all the terms and conditions set forth therein, except as may be otherwise expressly provided herein. sales force work order # 8872 is hereby terminated and no longer in effect. a. brief description of sales force project : sales force a full time sales force will be assigned to selling prochieve® 8 % progesterone gel ( “ prochieve 8 % ” ), prochieve® 4 % progesterone gel ( “ prochieve 4 % ” ), rephresh® vaginal gel ( “ rephresh ” ), and advantage - s® bioadhesive contraceptive gel ( “ advantage - s ” ) to a target list of obstetricians, gynecologists, and primary care physicians, and selling striant™ testosterone buccal system ( “ striant ” ) to a target list of endocrinologists, urologists, and primary care physicians. columbia ’ s and innovex ’ s objective is to maximize the quality of the calls and to work the total office to support the full columbia product line. the parties acknowledge and agree that the grant of rights to innovex hereunder is non - exclusive and nothing herein shall limit or restrict columbia ’ s right to market or promote the products itself or through a third party, in columbia ’ s sole discretion. b. project teams : meg coogan senior vice president, marketing and sales 354 eisenhower parkway livingston, nj 07039 # # # - # # # - # # # # # # # - # # # - # # # # tony yost president 10 waterview blvd. parsippany, nj 07054 # # # - # # # - # # # # # # # - # # # - # # # # 1 [ * * * ] a confidential portion of the material has been omitted and filed separately with the securities and exchange commission