exhibit 10. 43 portions of this exhibit marked [ * ] are requested to be treated confidentially. manufacturing expansion services agreement this services agreement ( this “ agreement ” ) is entered into, effective as of january 17, 2014 ( the “ effective date ” ), by and between cognate bioservices, a delaware corporation ( cognate ” ), and northwest biotherapeutics, a delaware corporation ( “ nw bio ” ). recitals whereas, nw bio is in the business of developing immune cell therapies for cancer, and cognate is in the business of manufacturing clinical grade cellular products on a contract services basis ; whereas, nw bio and cognate previously entered into a services agreement for the production of nw bio ’ s dcvax® products by cognate ( the “ prior services agreement ” ) and the conversion and lock - up agreement ( the “ lock - up agreement ” ) ; whereas, cognate has dedicated cgmp facilities and other facilities to nw bio programs, and conducted all of nw bio ’ s physical operations including all collections of patient tumor tissues and leukapheresis materials from clinical sites, all manufacturing, quality control, cryopreservation and banking of all dcvax® products, and all distribution and logistics to the point of care throughout the us, as well as management and oversight of all such functions in europe and israel ; whereas, both the quantity and the scope of services nw bio has requested that cognate provide greatly exceed the maximum scope and amounts contemplated or provided for in the prior services agreement [ * ] ; whereas, nw bio desires [ * ] ; whereas, nw bio has requested cognate to provide all necessary services to identify and evaluate potential sites for the manufacturing expansion [ * ] ; [ * ] ; [ * ] ; whereas, the parties also desire to update and reformulate their existing prior services agreement into a more comprehensive and complete set of four agreements including ( i ) this manufacturing expansion services agreement ; ( ii ) a dcvax - l manufacturing and services agreement, ( iii ) a new dcvax - direct manufacturing and services agreement, and ( iv ) a new ancilliary services agreement. [ * ] confidential treatment requested ; certain information omitted and filed separately with the sec. agreement now, therefore, in consideration of the foregoing recitals and the mutual promises, representations, warranties, and covenants hereinafter set forth, and for