votubia -lrb- everolimus -rrb- could shrink brain tumours by up to 50 per cent in children with the rare disease tuberous sclerosis complex . -lrb- cnn -rrb- -- a surrogate mother gave birth to twin girls for sarah jessica parker and matthew broderick , a publicist for the couple said . by . talal musa . published : . 12:37 est , 7 november 2012 . | . updated : . 12:44 est , 7 november 2012 . rating : . a drug that can shrink brain tumours by up to 50 per cent in children with a rare disease has been launched in the uk . nhs doctors will be able to apply for funding from health trusts for votubia -lrb- everolimus -rrb- for children with growing non-malignant brain tumours associated with a condition called tuberous sclerosis complex -lrb- tsc -rrb- . the once-a-day pill offers an alternative to surgery and could provide a lifeline for up to 1,600 youngsters in the uk with the tumours . the drug , which has been granted orphan drug status for rare diseases , has been shown to shrink subependymal giant cell astrocytoma -lrb- sega -rrb- tumours associated with tsc . tsc is a genetic disorder which leads to non-malignant tumours forming in organs , most commonly the brain and kidneys . real madrid are desperate to land manchester united goalkeeper david de gea , but they are prepared to wait until next summer if louis van gaal wo n't negotiate , according to reports in spain . brain tumours occur in up to 20 per cent of patients with tsc , causing physical and mental disability . chris kingswood , head of research at the tuberous sclerosis association , said : ` for a long time there has been a desperate need for a useful alternative licensed treatment to invasive brain surgery . the tuberous sclerosis association website . chris kingswood , who is head of research at the tuberous sclerosis association . ` everolimus is the first licensed product we can offer patients to attack the cause of their debilitating condition ; it works by blocking a protein that acts as an important regulator of tumour cell growth . sarah jessica parker and matthew broderick are the new parents of twin daughters . `` the babies are doing beautifully , and the entire family is over the moon , '' the publicist said , adding that the girls were born monday afternoon . in an age where games focus on showcasing feats of graphical accomplishment , it 's refreshing when a series pumps all its energy into gameplay . enter just dance 4 , the latest of the successful saga where players mimic dance moves that appear on screen - scoring points related to their accuracy . colourful : the game boasts a wonderful artistic style , backed up with fun gameplay . some may find , however , that is too similar to the other just dance games . thankfully , ubisoft have ensured there are plenty of songs worth dancing to . classics such as elvis presley 's jailhouse rock feature , while newer pop hits from the likes of one direction and flo rida ensure plenty of variation . some songs , however , are covers , and this can jar with the overall high-quality feel of the game . ` the way it works in the signalling pathway can be simply likened to blocking a receiver so it can not process signals from the aerial on an analogue radio , so that the signals can no longer transmit to drive in this case tumour cell growth . ' dr finbar o'callaghan , consultant in paediatric neurology at the university of bristol , said : ` sega is a serious complication in tsc , accounting for much of the increased mortality seen in this condition . ` until now , brain surgery has been the only option for treatment and the availability of a pharmacological therapy is a major milestone and provides a treatment option in those cases where surgery is difficult or not possible . ' de gea has been in fantastic form this season , while real 's legendary stopper iker casillas has long been seen as unreliable . although the european champions would like to sign de gea this june , they are looking at the possibility of picking up chelsea 's petr cech to fill the gap in between , while the spaniard runs down his contract at old trafford , which expires next year . all of the songs are available from the start , with unlockable playlists , alternative dance routines and more attainable with sufficient mojo - the game 's equivalent of experience points . immediately noticeable is just how well the game works with the kinect . often navigating menus in this way is cumbersome , but just dance 's virtual hand works wonderfully , letting you jump from track to track with minimum interruption . gameplay is strong , too . best played with friends , there are a number of songs with dance routines tailored to up to four players . dance battle sees two dancers battle through a series of songs , each with their own health bar , which diminishes when they lose a round . dance mash up allows you take on routines from the previous games , using the updated track list . but the real star of the show is the just sweat mode . here , calories as counted as you dance to the tracks , telling you how many have been burned . there are pre-made workouts , but you can also make your own - enhancing longevity , and providing an attractive option for those scared off by workout-specific games . this is made all the more enjoyable with the game 's wonderful , cartoon-esque visuals . it 's a shame , then , that just dance 4 may leave some wanting more . ubisoft have promised plenty of downloadable content , however , the game simply emulates its predecessors ' recipe , without adding any new ingredients - new game modes , for example . but why change a winning formula ? for this remains a brilliant family game ... and a perfect stocking filler this christmas . real madrid 's attempt to nab david de gea is the big story in as , while marca focus on james rodriguez . in a move that spanish paper as calls ` operation de gea ' , the paper claims real are only prepared to pay for the keeper if united ` fix a reasonable price ' - otherwise they will nab him for free in a year . de gea 's contract is up at old trafford in the summer of 2016 , and he is yet to sign a new deal , with united still uncertain of champions league football for next season . cech , meanwhile , looks certain to leave stamford bridge this summer , with the czech keeper likely to command a fee of around # 10million . follow talal on twitter : @talalmusa and on facebook : daily mail games . elsewhere in spain the focus is on lionel messi 's injury , which is still causing him some problems ahead of barcelona 's trip to celta vigo on sunday . sport say ` messi is ok ' , with the news that ` all tests were positive ' on his injured foot , and marca add that the barca star has ` overcome the pain ' . lionel messi 's injury dominates in sport , while in italy there is more news on palermo 's paulo dybala . however , the madrid-based paper also report that ` he still ca n't put his boot on ' because of the injury to his metatarsal . the couple , married for 12 years , revealed in april that they were expecting twins `` with the generous help of a surrogate . '' there is better news for james rodriguez , who is also set to return from injury , with marca reporting that he will start for real madrid on sunday , his first game for 59 days . in italy there are reports that palermo striker paulo dybala , who has been linked with arsenal , could join up with former manchester city manager roberto mancini at inter milan . it was not said whether the surrogate was the genetic mother of the twins or whether embryos from parker , 44 , had been transferred to her . `` marion loretta elwell broderick weighed five pounds , 11 ounces and tabitha hodge broderick weighed six pounds , '' the publicist said . `` both hodge and elwell are family names on parker 's side . '' parker is best known for the popular television series and movie `` sex and the city , '' while broderick gained fame as the main character in the movie `` ferris bueller 's day off . '' they have a son , james wilkie , 6 . he was named after broderick 's father , actor james broderick . corriere dello sport reports that inter are ready to offer # 22million for the argetinian youngster .
sarah jessica parker and matthew broderick have twin daughters . the babies were born via a surrogate . married for 12 years , the couple are also the parents of a 6-year-old boy .
brain tumours occur in up to 20 per cent of patients with tsc , causing physical and mental disability . chris kingswood , head of research at the tuberous sclerosis association , said : ` for a long time there has been a desperate need for a useful alternative licensed treatment to invasive brain surgery . the tuberous sclerosis association website . chris kingswood , who is head of research at the tuberous sclerosis association . ` everolimus is the first licensed product we can offer patients to attack the cause of their debilitating condition ; it works by blocking a protein that acts as an important regulator of tumour cell growth . sarah jessica parker and matthew broderick are the new parents of twin daughters . `` the babies are doing beautifully , and the entire family is over the moon , '' the publicist said , adding that the girls were born monday afternoon . in an age where games focus on showcasing feats of graphical accomplishment , it 's refreshing when a series pumps all its energy into gameplay . enter just dance 4 , the latest of the successful saga where players mimic dance moves that appear on screen - scoring points related to their accuracy . colourful : the game boasts a wonderful artistic style , backed up with fun gameplay . some may find , however , that is too similar to the other just dance games . thankfully , ubisoft have ensured there are plenty of songs worth dancing to . classics such as elvis presley 's jailhouse rock feature , while newer pop hits from the likes of one direction and flo rida ensure plenty of variation . some songs , however , are covers , and this can jar with the overall high-quality feel of the game . ` the way it works in the signalling pathway can be simply likened to blocking a receiver so it can not process signals from the aerial on an analogue radio , so that the signals can no longer transmit to drive in this case tumour cell growth . ' dr finbar o'callaghan , consultant in paediatric neurology at the university of bristol , said : ` sega is a serious complication in tsc , accounting for much of the increased mortality seen in this condition . ` until now , brain surgery has been the only option for treatment and the availability of a pharmacological therapy is a major milestone and provides a treatment option in those cases where surgery is difficult or not possible . ' de gea has been in fantastic form this season , while real 's legendary stopper iker casillas has long been seen as unreliable . although the european champions would like to sign de gea this june , they are looking at the possibility of picking up chelsea 's petr cech to fill the gap in between , while the spaniard runs down his contract at old trafford , which expires next year . all of the songs are available from the start , with unlockable playlists , alternative dance routines and more attainable with sufficient mojo - the game 's equivalent of experience points . immediately noticeable is just how well the game works with the kinect . often navigating menus in this way is cumbersome , but just dance 's virtual hand works wonderfully , letting you jump from track to track with minimum interruption . gameplay is strong , too . best played with friends , there are a number of songs with dance routines tailored to up to four players . dance battle sees two dancers battle through a series of songs , each with their own health bar , which diminishes when they lose a round . dance mash up allows you take on routines from the previous games , using the updated track list . but the real star of the show is the just sweat mode . here , calories as counted as you dance to the tracks , telling you how many have been burned . there are pre-made workouts , but you can also make your own - enhancing longevity , and providing an attractive option for those scared off by workout-specific games . this is made all the more enjoyable with the game 's wonderful , cartoon-esque visuals . it 's a shame , then , that just dance 4 may leave some wanting more . ubisoft have promised plenty of downloadable content , however , the game simply emulates its predecessors ' recipe , , actor james broderick . corriere dello sport reports that inter are ready to offer # 22million for the argetinian youngster .
non-malignant brain tumours associated with a condition called tuberous sclerosis complex -lrb- tsc -rrb- . the once-a-day pill offers an alternative to surgery and could provide a lifeline for up to 1,600 youngsters in the uk with the tumours . the drug , which has been granted orphan drug status for rare diseases , has been shown to shrink subependymal giant cell astrocytoma -lrb- sega -rrb- tumours associated with tsc . tsc is a genetic disorder which leads to non-malignant tumours forming in organs , most commonly the brain and kidneys . real madrid are desperate to land manchester united goalkeeper david de gea , but they are prepared to wait until next summer if louis van gaal wo n't negotiate , according to reports in spain . the babies are doing beautifully , and the entire family is over the moon , '' the publicist said , adding that the girls were born monday afternoon . in an age where games focus on showcasing feats of graphical accomplishment , it 's refreshing when a series pumps all its energy into gameplay . enter just dance 4 , the latest of the successful saga where players mimic dance moves that appear on screen - scoring points related to their accuracy . colourful : the game boasts a wonderful artistic style , backed up with fun gameplay . some may find , however , that is too similar to the other just dance games . thankfully , ubisoft have ensured there are plenty of songs worth dancing to . classics such as elvis presley 's jailhouse rock feature , while newer pop hits from the likes of one direction and flo rida ensure plenty of variation . some songs , however , are covers , and this can jar with the overall high-quality feel of the game . ` the way it works in the signalling pathway can be simply likened to blocking a receiver so it can not process signals from the aerial on an analogue radio , so that the signals can no longer transmit to drive in this case tumour cell growth . ' dr finbar o'callaghan , consultant in paediatric neurology at the university of bristol , said : ` sega is a serious complication in tsc , accounting for much of the increased mortality seen in this condition . ` until now , brain surgery has been the only option for treatment and the availability of a pharmacological therapy is a major milestone and provides a treatment option in those cases where surgery is difficult or not possible . ' de gea has been in fantastic form this season , while real 's legendary stopper iker casillas has long been seen as unreliable . although the european champions would like to sign de gea this june , they are looking at the possibility of picking up chelsea 's petr cech to fill the gap in between , while the spaniard runs down his contract at old trafford , which expires next year . all of the songs are available from the start , with unlockable playlists , alternative dance routines and more attainable with sufficient mojo - the game 's equivalent of experience points . immediately noticeable is just how well the game works with the kinect . often navigating menus in this way is cumbersome , but just dance 's virtual hand works wonderfully , letting you jump from track to track with minimum interruption . gameplay is strong , too . best played with friends , there are a number of songs with dance routines tailored to up to four players . dance battle sees two dancers battle through a series of songs , each with their own health bar , which diminishes when they lose a round . dance mash up allows you take on routines from the previous games , using the updated track list . but the real star of the show is the just sweat mode . here , calories as counted as you dance to the tracks , telling you how many have been burned . there are pre-made workouts , but you can also make your own - enhancing longevity , and providing an attractive option for those scared off by workout-specific games . this is made all the more enjoyable with the game 's wonderful , cartoon-esque visuals . it 's a shame , then , that just dance 4 may leave some wanting more . ubisoft have promised plenty of downloadable content , however , the game simply emulates its predecessors ' recipe , without adding any new ingredients - new game modes , for example . but why change a winning formula ? for this remains a brilliant family game ... and a perfect stocking filler this christmas . real madrid 's attempt to nab david de gea is the big story in as , while marca focus on james rodriguez . in a move that spanish paper as calls ` operation de gea ' , the paper claims real are only prepared to pay for the keeper if united ` fix a reasonable price ' - otherwise they will nab him for free in a year . de gea 's contract is up at old trafford in the summer of 2016 , and he is yet to sign a new , actor james broderick . corriere dello sport reports that inter are ready to offer # 22million for the argetinian youngster .
votubia -lrb- everolimus could shrink brain tumours children the rare disease tuberous sclerosis complex. -lrb- cnn -- a surrogate mother gave twin girls for sarah jessica parker matthew broderick, a publicist the couple. by. talal musa. published :. 12:37 est, 7 november. |. updated :. 12:44 est, 7 november. rating. a drug shrink brain tumours children has launched the uk. nhs doctors will apply funding health trusts votubia -lrb- everolimus for children associated a condition tuberous sclerosis complex tsc. the once pill offers surgery could provide up to 1,600 youngsters the uk with the tumours. the drug, granted orphan drug status rare diseases has shrink subependymal giant cell astrocytoma -lrb- sega associated tsc. tsc is a genetic disorder leads forming organs, most kidneys real madrid are desperate land manchester united goalkeeper david de gea, prepared louis van gaal wo n't negotiate, according spain brain tumours occur tsc, causing. chris kingswood, head research the tuberous sclerosis association said : ` for a desperate need a useful alternative licensed treatment invasive brain surgery. the tuberous sclerosis association website. chris kingswood, who head research the tuberous sclerosis association. ` everolimus is the first licensed product we can patients to attack the cause their debilitating condition ; works blocking acts. sarah jessica parker and matthew broderick are the new parents twin daughters. `` the babies doing beautifully, the entire family over, '' the publicist, born monday afternoon in an age games focus showcasing feats graphical accomplishment, 's refreshing when a series pumps all its energy gameplay enter just dance 4, the latest of the successful saga where players mimic that appear screen - scoring points related their accuracy. colourful : the game boasts a wonderful artistic style, backed fun gameplay. some may, however is too similar the other just dance games thankfully, ubisoft ensured there plenty songs worth dancing. classics such elvis presley 's jailhouse rock feature, while newer pop from one direction flo rida ensure plenty variation. some songs, however, covers, can jar with the overall high-quality feel ` the way the signalling pathway can simply likened blocking a receiver so not process the aerial on an analogue radio, so no transmit drive in this case tumour cell growth. ' dr finbar o'callaghan, consultant in paediatric neurology the university bristol, said : ` sega is a serious complication tsc accounting much seen. ` until, brain surgery treatment and the availability a pharmacological therapy a major milestone and provides in those cases surgery difficult. ' de gea has in fantastic form this, while real 's legendary stopper iker casillas has long seen unreliable. although the european champions would sign de gea this june, looking picking chelsea 's petr cech to fill between, while spaniard runs down his contract old trafford expires all the songs available from the start, with unlockable playlists, alternative dance routines attainable sufficient mojo - the game 's equivalent experience points immediately noticeable is just well the kinect. often navigating menus this way cumbersome, just dance 's virtual hand works wonderfully, letting jump track minimum interruption. gameplay strong, too. best played friends, there songs with dance routines tailored up to four players dance battle sees two dancers battle through songs, their own health bar diminishes lose a round dance mash allows take routines the previous games, using the updated track list. but the real star the just sweat mode. here, calories as counted you dance the tracks, telling have burned. there pre-made workouts, your own - enhancing longevity, providing an attractive option scared off workout-specific games this made all enjoyable with the game 's wonderful, cartoon-esque visuals. it 's a shame, then just dance 4 may leave some wanting. ubisoft have promised plenty, however, simply emulates its predecessors ' recipe, without any new ingredients - new game modes for but why change a winning formula? for this remains a brilliant family game... and a perfect stocking filler this christmas. real madrid 's attempt nab david de gea is the big story as, while marca focus james rodriguez. in a move that spanish paper as calls ` operation de gea ' the paper claims real are only prepared the keeper if united ` fix a reasonable price ' - otherwise nab free in a year. de gea 's contract is up at old trafford in the summer, yet, with united still uncertain of champions league football for cech, meanwhile looks certain leave stamford bridge this, the czech keeper likely command # 10million. follow talal on : and on daily mail games. elsewhere spain the focus lionel messi 's injury, still causing ahead barcelona 's trip celta vigo sunday sport say ` messi is ok, with the news ` all tests positive ' on his injured foot, marca add the barca star ` overcome lionel messi 's injury dominates in sport, while in italy there more news palermo 's paulo dybala. however, the madrid-based paper also report ` he still ca n't put his boot ' because the injury. the couple, married revealed april that twins `` with the generous help surrogate. '' there better news james rodriguez, also set return, with marca reporting start real madrid sunday, 59 days in italy there reports palermo striker paulo dybala, arsenal, could former manchester city manager roberto mancini at inter milan it not said whether the surrogate the genetic mother embryos parker, 44 had her. `` marion loretta elwell broderick weighed five pounds, 11 ounces tabitha hodge broderick '' the publicist. `` both hodge and elwell family names on parker 's side. '' parker is best the popular television series and sex, while broderick gained `` ferris bueller 's day off '' they a son, james wilkie 6. he named after broderick 's father, actor james broderick corriere dello sport reports inter are ready offer # 22million the argetinian youngster.
brain tumours occur in up to 20 per cent of patients with tsc , causing physical and mental disability . chris kingswood , head of research at the tuberous sclerosis association , said : ` for a long time there has been a desperate need for a useful alternative licensed treatment to invasive brain surgery . the tuberous sclerosis association website . chris kingswood , who is head of research at the tuberous sclerosis association . ` everolimus is the first licensed product we can offer patients to attack the cause of their debilitating condition ; it works by blocking a protein that acts as an important regulator of tumour cell growth . sarah jessica parker and matthew broderick are the new parents of twin daughters . `` the babies are doing beautifully , and the entire family is over the moon , '' the publicist said , adding that the girls were born monday afternoon . in an age where games focus on showcasing feats of graphical accomplishment , it 's refreshing when a series pumps all its energy into gameplay . enter just dance 4 , the latest of the successful saga where players mimic dance moves that appear on screen - scoring points related to their accuracy . colourful : the game boasts a wonderful artistic style , backed up with fun gameplay . some may find , however , that is too similar to the other just dance games . thankfully , ubisoft have ensured there are plenty of songs worth dancing to . classics such as elvis presley 's jailhouse rock feature , while newer pop hits from the likes of one direction and flo rida ensure plenty of variation . some songs , however , are covers , and this can jar with the overall high-quality feel of the game . ` the way it works in the signalling pathway can be simply likened to blocking a receiver so it can not process signals from the aerial on an analogue radio , so that the signals can no longer transmit to drive in this case tumour cell growth . ' dr finbar o'callaghan , consultant in paediatric neurology at the university of bristol , said : ` sega is a serious complication in tsc , accounting for much of the increased mortality seen in this condition . ` until now , brain surgery has been the only option for treatment and the availability of a pharmacological therapy is a major milestone and provides a treatment option in those cases where surgery is difficult or not possible . ' de gea has been in fantastic form this season , while real 's legendary stopper iker casillas has long been seen as unreliable . although the european champions would like to sign de gea this june , they are looking at the possibility of picking up chelsea 's petr cech to fill the gap in between , while the spaniard runs down his contract at old trafford , which expires next year . all of the songs are , actor james broderick . corriere dello sport reports that inter are ready to offer # 22million for the argetinian youngster .
 The article discusses the entertainment aspect of a new treatment for tuberous sclerosis complex (TSC), a genetic disorder that causes physical and mental disabilities. The treatment, called Everolimus, is the first licensed product to tackle the root cause of TSC, blocking a protein that acts as an important regulator of tumor cell growth. The article highlights how this breakthrough can bring hope to patients with TSC, who often suffer from debilitating symptoms such as seizures, learning difficulties, and behavioral problems.