a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . a newly-released film about manny pacquiao offers a look into the philippine boxer 's childhood ahead of his much anticipated fight against floyd mayweather jnr next month . the protein , called fndc5 , is produced by muscular exertion and is released into the bloodstream as a hormone called irisin . a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . they hope to use it to keep the neurons in the human brain healthy while also making new ones . ` what is exciting is that a natural substance can be given in the bloodstream that can mimic some of the effects of endurance exercise on the brain , ' said professor bruce spiegelman , from dana-farber cancer institute in boston . ` our results indicate that fndc5/irisin has the ability to control a very important neuro-protective pathway in the brain . ' in the study , laboratory mice regularly ran on a wheel for 30 days . the exercise spurred a rise in the fndc5 protein . that in turn increased a protein called brain-derived neurotrophic protein -lrb- bdnf -rrb- in a part of the brain involved in learning and memory . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . they used a harmless virus to deliver the protein to mice through the bloodstream , in hopes the fndc5 could reach the brain and raise bdnf production . seven days later , they examined the mouse brains and observed a significant increase in bdnf in the hippocampus area of the brain . professor spiegelman says more research is needed and the next step is to develop a stable form of irisin . antarctica has experienced its highest temperature on record , according to meteorologists . ` kid kulafu ' , named after a brand of wine whose bottles pacquiao collected as a child , charts his rise from humble beginnings to his first step into the boxing ring . ` he 's just like every one of us , ' director paul soriano said at the film 's manila premiere on tuesday night . ` he was born with nothing but because of god , because of hard work and faith , he became something . ' scroll down to watch the trailer . film director paul soriano -lrb- left -rrb- with actors buboy villar and alessandra de ross at the premiere of kid kulafu . villar -lrb- right -rrb- plays the part of a young pacquiao as he rises from humble beginnings to a boxing career . sensors at argentina 's esperanza base on the northern tip of the antarctic peninsula recorded a temperature of 17.5 °c -lrb- 63.5 °f -rrb- . according to meteorologists this is potentially a new record for the warmest temperature measured on the frozen continent . the new temperature record was measured on the northern tip of the antarctic peninsula -lrb- pictured -rrb- where the ice shelf covering the sea has declined considerably in recent years and glaciers are thought to be receding . soriano spent two years researching the film , much of it based on conversations with 36-year-old pacquiao . over a two day period last week temperatures reached 17.4 °c -lrb- 63.3 °f -rrb- and 17.5 °c -lrb- 63.5 °f -rrb- . ` everyone can mimic his moves , but you ca n't easily copy his courage , ' said buboy villar , who plays the young boxer . ` pacquiao always faces people who are bigger than him and , as you can see , he 's scrawny as a kid , so i think all the rough experiences he had growing up helped to make him strong . ' the film opened in philippine cinemas on wednesday and will be shown in selected cinemas in the us and canada later this month . pacquiao faces mayweather on may 2 at the mgm grand garden arena in las vegas in a fight that is expected to gross more than $ 300million . pacquiao grew up in the philippines and was born with little before becoming a successful boxer . however , the heatwave on the coldest continent on earth has still to be officially certified by the world meteorological organisation . antarctica 's icy edge is disappearing in warming ocean waters , with the last decade seeing the rate of ice loss increase dramatically . this is according to a new study that has combined 18-years worth of ice shelf thinning data from three different sets of satellites . the researchers claim that some ice shelves in west antarctica have lost as much as 18 per cent of their volume in the last ten years . the film charts pacquiao 's boxing career from his earliest fights as a youngster in the philippines . satellite data from 1994 to . 2012 clearly shows the accelerating decline which could hasten the rise in global sea levels , . scientists say . the findings come amid concern among many scientists about the effects of . pacquiao is preparing to take on floyd mayweather in las vegas on may 2 in their $ 300million fight . mayweather works out with his uncle roger at the mayweather boxing club ahead of his fight against pacquiao . global climate change on earth 's vast , remote polar regions . the previous hottest temperature recorded in antarctica - which is usually the coldest place on earth - was in april 24 1961 when the temperature reached 17.1 °c -lrb- 62.8 °f -rrb- . writing for website weather underground , meteorologist dr jeff masters said : ' a new all-time temperature record for an entire continent is a rare event . ` this week 's record temperatures were made possible by an unusually extreme jet stream contortion that brought a strong ridge of high pressure over the antarctic peninsula , allowing warm air from south america to push southwards over antarctica . ` at the surface , west to east blowing winds over the antarctic peninsula rose up over the 1,000-foot high mountains just to the west of esperanza base , then descended and warmed via adiabatic compression -lrb- without transfer of heat -rrb- into a warm foehn wind -lrb- a warm dry wind that blows down a slope -rrb- . ' antarctica is known as the coldest place on earth where temperatures have dropped to -93.2 °c -lrb- -135.8 °f -rrb- on the east antarctic plateau . the graphic above shows rates of thickness change around the antarctic coastline with areas of most loss in the past 18 years indicated by red circles and areas where ice has increased shown by blue circles . however , the antarctic peninsula is one of the fastest warming spots on earth . while most of the continent has experienced an increase in ice sheet mass , nearly 10,000 square miles of ice has been lost from the ice shelves off coast of the peninsula . glaciers extending out from the fjords of the antarctic peninsula have also been retreating , according to researchers . climate scientists have blamed the changes happening there on human-generated global warming . the collapse of the larson b shelf -lrb- shown above -rrb- on the antarctic peninsula is one example of the changes that have been taking place on the continent in recent years and have caused concern among some scientists . marine sediment cores suggest the changes happening in the area are unprecedented at least in the past 10,000 years . dr masters said last week 's heatwave matched a trend occurring around the world . he said that in 2015 five nations or territories have now set all time records or matched their records for hottest temperatures in history . he added that 46 nations or territories , out of 235 , have set or tied all time heat records since 2010 . however , despite the new record temperature , climate scientists are urging caution about drawing conclusions from it . this graphic shows how warm water from the ocean may be increasing the flow of glaciers from the antarctic ice sheet as they cause melting from below while fresh snow accumulates on top of the ice sheet . gavin schmidt , a climate scientist with nasa 's goddard institute for space studies in new york , told national geographic that last year antarctica also logged a record cold temperature . he said that long term climate changes in antarctica are complex and still have not been complained properly . the new record will also depend on what scientists regard as being antarctica . currently the world meteorological society records the warmest temperature on the continent as being at vanda station on the opposite side antarctica on 1 may 1974 when temperatures reached 15 °c -lrb- 59 °f -rrb- .
walking could hold key to slowing onset of alzheimer 's and parkinson 's . chemical produced by body during exercise could be given as injection .
a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . a newly-released film about manny pacquiao offers a look into the philippine boxer 's childhood ahead of his much anticipated fight against floyd mayweather jnr next month . the protein , called fndc5 , is produced by muscular exertion and is released into the bloodstream as a hormone called irisin . a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . they hope to use it to keep the neurons in the human brain healthy while also making new ones . ` what is exciting is that a natural substance can be given in the bloodstream that can mimic some of the effects of endurance exercise on the brain , ' said professor bruce spiegelman , from dana-farber cancer institute in boston . ` our results indicate that fndc5/irisin has the ability to control a very important neuro-protective pathway in the brain . ' in the study , laboratory mice regularly ran on a wheel for 30 days . the exercise spurred a rise in the fndc5 protein . that in turn increased a protein called brain-derived neurotrophic protein -lrb- bdnf -rrb- in a part of the brain involved in learning and memory . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . they used a harmless virus to deliver the protein to mice through the bloodstream , in hopes the fndc5 could reach the brain and raise bdnf production . seven days later , they examined the mouse brains and observed a significant increase in bdnf in the hippocampus area of the brain . professor spiegelman says more research is needed and the next step is to develop a stable form of irisin . antarctica has experienced its highest temperature on record , according to meteorologists . ` kid kulafu ' , named after a brand of wine whose bottles pacquiao collected as a child , charts his rise from humble beginnings to his first step into the boxing ring . ` he 's just like every one of us , ' director paul soriano said at the film 's manila premiere on tuesday night . ` he was born with nothing but because of god , because of hard work and faith , he became something . ' scroll down to watch the trailer . film director paul soriano -lrb- left -rrb- with actors buboy villar and alessandra de ross at the premiere of kid kulafu . villar -lrb- right -rrb- plays the part of a young pacquiao as he rises from humble beginnings to a boxing career . sensors at argentina 's esperanza base on the northern tip of the antarctic peninsula recorded a temperature of be officially certified by the world meteorological organisation . antarctica 's icy edge is disappearing in warming ocean waters , with the last decade seeing the rate of ice loss increase dramatically . this is according to a new study that has combined 18-years worth of ice shelf thinning data from three different sets of satellites . the researchers claim that some ice shelves in west antarctica have lost as much as 18 per cent of their volume in the last ten years . the film charts pacquiao 's boxing career from his earliest fights as a youngster in the philippines . satellite data from 1994 to . 2012 clearly shows the accelerating decline which could hasten the rise in global sea levels , . scientists say . the findings come amid concern among many scientists about the effects of . pacquiao is preparing to take on floyd mayweather in las vegas on may 2 in their $ 300million fight . mayweather works out with his uncle roger at the mayweather boxing club ahead of his fight against pacquiao . global climate change on earth 's vast , remote polar regions . the previous hottest temperature recorded in antarctica - which is usually the coldest place on earth - was in april 24 1961 when the temperature reached 17.1 °c -lrb- 62.8 °f -rrb- . writing for website weather underground , meteorologist dr jeff masters said : ' a new all-time temperature record for an entire continent is a rare event . ` this week 's temperatures reached 15 °c -lrb- 59 °f -rrb- .
a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . a newly-released film about manny pacquiao offers a look into the philippine boxer 's childhood ahead of his much anticipated fight against floyd mayweather jnr next month . the protein , called fndc5 , is produced by muscular exertion and is released into the bloodstream as a hormone called irisin . a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . they hope to use it to keep the neurons in the human brain healthy while also making new ones . ` what is exciting is that a natural substance can be given in the bloodstream that can mimic some of the effects of endurance exercise on the brain , ' said professor bruce spiegelman , from dana-farber cancer institute in boston . ` our results indicate that fndc5/irisin has the ability to control a very important neuro-protective pathway in the brain . ' in the study , laboratory mice regularly ran on a wheel for 30 days . the exercise spurred a rise in the fndc5 protein . that in turn increased a protein called brain-derived neurotrophic protein -lrb- bdnf -rrb- in a part of the brain involved in learning and memory . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . they used a harmless virus to deliver the protein to mice through the bloodstream , in hopes the fndc5 could reach the brain and raise bdnf production . seven days later , they examined the mouse brains and observed a significant increase in bdnf in the hippocampus area of the brain . professor spiegelman says more research is needed and the next step is to develop a stable form of irisin . antarctica has experienced its highest temperature on record , according to meteorologists . ` kid kulafu ' , named after a brand of wine whose bottles pacquiao collected as a child , charts his rise from the young boxer . ` pacquiao always faces people who are bigger than him and , as you can see , he 's scrawny as a kid , so i think all the rough experiences he had growing up helped to make him strong . ' the film opened in philippine cinemas on wednesday and will be shown in selected cinemas in the us and canada later this month . pacquiao faces mayweather on may 2 at the mgm grand garden arena in las vegas in a fight that is expected to gross more than $ 300million . pacquiao grew up in the philippines and was born with little before becoming a successful boxer . however , the heatwave on the coldest continent on earth has still to be officially certified by the world meteorological organisation . antarctica 's icy edge is disappearing in warming ocean waters , with the last decade seeing the rate of ice loss increase dramatically . this is according to a new study that has combined 18-years worth of ice shelf thinning data from three different sets of satellites . the researchers claim that some ice shelves in west antarctica have lost as much as 18 per cent of their volume in the last ten years . the film charts pacquiao 's boxing career from his earliest fights as a youngster in the philippines . satellite data from 1994 to . 2012 clearly shows the accelerating decline which could hasten the rise in global sea levels , . scientists say . the findings come amid concern among many scientists about the effects of . pacquiao is preparing to take on floyd mayweather in las vegas on may 2 in their $ 300million fight . mayweather works out with his uncle roger at the mayweather boxing club ahead of his fight against pacquiao . global climate change on earth 's vast , remote polar regions . the previous hottest temperature recorded in antarctica - which is usually the coldest place on earth - was in april 24 1961 when the temperature reached 17.1 °c -lrb- 62.8 °f -rrb- . writing for website weather underground , meteorologist dr jeff masters said : ' a new all-time temperature record for an entire continent is a rare event . ` this week 's one example of the changes that have been taking place on the continent in recent years and have caused concern among some scientists . marine sediment cores suggest the changes happening in the area are unprecedented at least in the past 10,000 years . dr masters said last week 's heatwave matched a trend occurring around the world . he said that in 2015 five nations or territories have now set all time records or matched their records for hottest temperatures in history . he added that 46 nations or territories , out of 235 , have set or tied all time heat records since 2010 . however , despite the new record temperature , climate scientists are urging caution about drawing conclusions from it . this graphic temperatures reached 15 °c -lrb- 59 °f -rrb- .
a rigorous walk could hold slowing alzheimer 's and parkinson in. a natural chemical produced during exercise could one day given inhibit the diseases, researchers a newly-released film manny pacquiao offers the philippine boxer 's childhood ahead his much anticipated fight floyd mayweather jnr next. the protein, called fndc5 produced muscular exertion released a hormone irisin a rigorous walk could hold slowing alzheimer 's and parkinson in. they hope use keep the neurons while making new ones. ` what exciting a natural substance given in the bloodstream that mimic some endurance exercise on, ' professor bruce spiegelman from dana-farber cancer institute boston ` our results indicate fndc5/irisin has control a very important neuro-protective pathway. ' in the study laboratory mice regularly ran a wheel for. the exercise spurred a rise the fndc5 protein. that in turn increased a protein called brain-derived neurotrophic protein -lrb- bdnf -rrb- in a part involved. a natural chemical produced during exercise could one day given inhibit the diseases, researchers they used a harmless virus deliver the protein mice through, in hopes the fndc5 could reach raise bdnf production seven days, they examined the mouse brains observed bdnf in the hippocampus area. professor spiegelman says more research and the next step develop a stable form irisin. antarctica has experienced its highest temperature, meteorologists. ` kid kulafu ', named a brand wine whose bottles pacquiao collected as, charts his rise his first step the boxing ring ` he 's just every one, ' director paul soriano at the film 's manila premiere tuesday night ` he was born with nothing because god, because hard work faith he became something. ' scroll watch. film director paul soriano -lrb- left -rrb- with actors buboy villar and alessandra de ross at kid kulafu. villar -lrb- right -rrb- plays the part a young pacquiao as rises humble beginnings a boxing career. sensors at argentina 's esperanza base on the northern tip the antarctic peninsula recordedc -lrb- 63.5 -rrb-. according meteorologists this potentially measured the frozen continent. the new temperature record was measured the northern tip the antarctic peninsula -lrb- pictured -rrb- where covering has declined considerably and glaciers thought. soriano spent researching the film, much based conversations 36-year-old pacquiao. over a two day period last temperatures reached 17.4 °c -lrb- 63.3 -rrb- and. ` everyone can mimic his moves, ca n't easily copy his courage ' said buboy villar who plays the young boxer. ` pacquiao always faces people bigger, as you 's scrawny as a kid so i all the rough experiences growing helped to strong. ' the film opened philippine cinemas wednesday will the us and canada later. pacquiao faces mayweather on may 2 at the mgm grand garden arena las vegas in a fight gross more than $ 300million. pacquiao grew the philippines born with little before becoming. however, the heatwave on the coldest continent still to officially certified. antarctica 's icy edge disappearing in warming, with the last decade seeing the rate dramatically this according combined 18-years worth ice shelf thinning data three different sets satellites. the researchers claim some ice shelves west antarctica lost. the film charts pacquiao 's boxing career from his earliest fights as the philippines. satellite data 1994. 2012 clearly the accelerating decline which could hasten,. scientists say. the findings come amid concern many scientists. pacquiao is preparing floyd mayweather las vegas on may 2 in their $ 300million fight. mayweather works out with his uncle roger at the mayweather boxing club ahead pacquiao. global climate change on earth 's vast, remote polar regions. the previous hottest temperature recorded antarctica - which usually in april 24 1961 whenc -lrb- 62.8 -rrb-. writing for website weather underground, meteorologist dr jeff masters said : ' a new all-time temperature record an entire continent a rare event. ` this week 's record temperatures made an unusually extreme jet stream contortion brought a strong ridge the antarctic peninsula, allowing south america push southwards over antarctica ` at the surface, west to blowing winds over the antarctic peninsula rose up over just to esperanza base, then descended and warmed via adiabatic compression -lrb- without transfer into a warm foehn wind a warm dry wind blows down a slope. ' antarctica is known where temperatures -93.2c -lrb- -135.8 -rrb- on the east antarctic plateau. the graphic above rates thickness change around the antarctic coastline with areas most loss in the past 18 years indicated red circles areas ice increased shown. however, the antarctic peninsula one the fastest warming spots while most the continent experienced ice sheet mass, nearly 10,000 square miles from off coast the peninsula. glaciers extending the fjords the antarctic peninsula have also retreating, researchers. climate scientists blamed the changes happening there. the collapse the larson b shelf -lrb- shown on the antarctic peninsula is one example the changes and caused concern. marine sediment cores suggest the changes happening unprecedented at least. dr masters said last week 's heatwave matched a trend occurring. he said in 2015 five nations or territories have now set all time records or matched hottest temperatures. he added 46 nations or, out 235, set or tied all time heat records since 2010 however, despite the new record temperature climate scientists urging drawing it this graphic how warm water from may increasing the flow glaciers from as cause melting from below while fresh. gavin schmidt, a climate scientist nasa 's goddard institute in new york told national geographic that last year antarctica also logged a record cold temperature. he said long term climate changes in antarctica complex still have complained properly. the new record will also depend what scientists regard being antarctica. currently the world meteorological society records the warmest temperature the continent as being vanda station on the opposite side antarctica on 1 may 1974 when temperatures reached 15 °c -lrb- 59 ° -rrb-.
a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . a newly-released film about manny pacquiao offers a look into the philippine boxer 's childhood ahead of his much anticipated fight against floyd mayweather jnr next month . the protein , called fndc5 , is produced by muscular exertion and is released into the bloodstream as a hormone called irisin . a rigorous walk could hold the key to slowing the onset of alzheimer 's and parkinson 's in later life . they hope to use it to keep the neurons in the human brain healthy while also making new ones . ` what is exciting is that a natural substance can be given in the bloodstream that can mimic some of the effects of endurance exercise on the brain , ' said professor bruce spiegelman , from dana-farber cancer institute in boston . ` our results indicate that fndc5/irisin has the ability to control a very important neuro-protective pathway in the brain . ' in the study , laboratory mice regularly ran on a wheel for 30 days . the exercise spurred a rise in the fndc5 protein . that in turn increased a protein called brain-derived neurotrophic protein -lrb- bdnf -rrb- in a part of the brain involved in learning and memory . a natural chemical produced by the body during exercise could one day be given as an injection to inhibit the diseases , researchers say . they used a harmless virus to deliver the protein to mice through the bloodstream , in hopes the fndc5 could reach the brain and raise bdnf production . seven days later , they examined the mouse brains and observed a significant increase in bdnf in the hippocampus area of the brain . professor spiegelman says more research is needed and the next step is to develop a stable form of irisin . antarctica has experienced its highest temperature on record , according to meteorologists . ` kid kulafu ' , named after a brand of wine whose bottles pacquiao collected as a child , charts his rise from humble beginnings to his first step into the boxing ring . ` he 's just like every one of us , ' director paul soriano said at the film 's manila premiere on tuesday night . ` he was born with nothing but because of god , because of hard work and faith , he became something . ' scroll down to watch the trailer . film director paul soriano -lrb- left -rrb- with actors buboy villar and alessandra de ross at the premiere of kid kulafu . villar -lrb- right -rrb- plays the part of a young pacquiao as he rises from humble beginnings to a boxing career . sensors at argentina 's esperanza base on the northern tip of the antarctic peninsula recorded a temperature of temperatures reached 15 °c -lrb- 59 °f -rrb- .
 The text discusses the potential benefits of rigorous walking in slowing down the onset of Alzheimer's and Parkinson's diseases. A natural chemical produced by the body during exercise, called FNDc5, has been found to mimic some of the effects of endurance exercise on the brain. Researchers believe that this chemical could be used as an injection to inhibit the diseases. The study involved mice running on wheels and found that the FNDc5 protein was released into the bloodstream, which then traveled to the brain and improved cognitive function. The researchers hope to use this discovery to develop new treatments for neurodegenerative diseases.