people who carry a lot of fat around their middles are three and a half times more likely to develop memory loss and dementia in old age , research shows . scientists have found that people with a lot of abdominal fat have lower levels of the protein that also controls how the liver metabolises fat . called pparalpha , it controls fat metabolism in the liver , but . it also resides in the brain 's memory centre -- the hippocampus -- and . haul : the cherry picker collecting drugs from the roof of hmp altcourse in liverpool . controls memory and learning . people who carry a lot of fat around their middles are three and a half times more likely to develop memory loss and dementia in old age . when people are overweight , they initially just have depleted pparalpha levels in their livers but eventually in their whole bodies , including their brains . neurological scientists at the rush university medical centre , in chicago , in collaboration with the national institutes of health , believe their finding could lead to the development of an injection to improve learning and memory in people with dementia . dr kalipada pahan from rush university medical centre said : ` we need to better understand how fat is connected to memory and learning so that we can develop effective approach to protect memory and learning . ` while pparalpha deficient mice are poor in learning and memory , injection of pparα to the hippocampus improves learning and memory . ' dr pahan said : ` further research must be conducted to see how we could potentially maintain normal pparalpha in the brain in order to be resistant to memory loss . ' researchers found people with a lot of abdominal fat have lower levels of the nuclear regulator pparalpha in their livers and brains making them 3.6 times more likely to develop dementia . the research was published in the journal cell reports . previous research has suggested that passive smoking , sleep apnoea , drinking and taking drugs , type 2 diabetes and heart disease can all also increase a person 's risk of dementia . dementia currently affects about 800,000 people in the uk . los angeles , california -lrb- cnn -rrb- -- he got a standing ovation before the orchestra even played a single note . the amount of drugs being thrown over the fence into one prison is so high that warders have been forced to deploy a cherry picker to remove them . packages containing heroin and cannabis were cleared from the roof of hmp altcourse in liverpool - hurled there from the outside by friends of inmates who missed their intended targets . the hydraulic crane also recovered so-called ` legal highs ' as well as 22 phones , three sim cards and six chargers from the 60ft roof , contained in a total of 14 bubble-wrapped packages . officers at the jail , privately run by controversial firm g4s , disclosed the haul in an internal document , which dramatically highlights the extent of drug use among the jail 's 1,300 inmates . dave thompson , director of the category b prison , said : ` these items were thrown over the prison walls by criminals on the outside and it required a cherry picker and staff to retrieve them from inaccessible rooftops . ' altcourse , the first prison in the uk to be designed and constructed for a private operator , has been criticised for drug-related violence . gustavo dudamel has been compared to the legendary leonard bernstein by one critic . for weeks now , anticipation has been growing for the arrival of fiery young venezuelan conductor gustavo dudamel to take over the los angeles philharmonic , and the crowd could n't wait to roar its approval at his arrival . dudamel , 28 , engenders a passion among music lovers that is entirely new to the world of classical music . tickets for his saturday debut as music director of the los angeles philharmonic disappeared within minutes -- the fastest sellout in the history of the 18,000-seat hollywood bowl . `` he is a phenomenon , '' said mark swed , los angeles times music critic . `` he generates excitement the likes of which has n't come around in a very , very long time -- maybe since leonard bernstein . '' watch the exciting dudamel wield the baton '' after a three-day visit last june , chief inspector of prisons chris hardwick wrote : ` there have been 38 serious assaults in just four months before the inspection . gang issues and the availability of drugs , particularly new psychoactive substances -lsb- legal highs -rsb- were a significant factor in much of the violence . ' g4s insists that altcourse runs an effective anti-smuggling operation , and that the cherry picker is part of a ` high-visibility ' approach to show inmates they will ` root out packages from anywhere ' . ` we are committed to preventing drugs coming into our prison and we are encouraged that , at the same time as our seizures of banned substances have increased , the numbers of prisoners testing positive for them has come down , ' said mr thompson . swed was in the audience two years ago when dudamel conducted the simon bolivar youth orchestra at the walt disney concert hall , delivering a reading of beethoven 's fourth symphony that left fans delirious . `` i have n't seen that kind of reaction from a crowd since i saw the beatles at dodger stadium , '' swed said . dudamel 's face has been a common sight for months in los angeles . his billboards look down on freeway commuters . he adorns city buses . at the famous hollywood hot dog stand pink 's , there is even a dog named in his honor -- the `` dude dog , '' piled high with jalapeno peppers , guacamole and tortilla chips . while it 's not exactly venezuelan cuisine , in los angeles , there can be no surer sign that the conductor known as `` the dude '' has arrived . so where did dudamel get this musical magic ? he said at least a part of his talent is inherited . `` i started studying music when i was 4 , '' he said . `` i wanted to play trombone like my father . '' soon young gustavo entered into el sistema , venezuela 's state-financed music education program . hundreds of thousands of children have received instruments and music instruction through the nation 's massive system of youth orchestras . `` you can not imagine , '' said dudamel , `` how it changes the life of a kid if you put a violin or a cello or a flute -lsb- in his hand -rsb- . you feel you have your world . you have your life there , and it changes your life . this happened to me . '' as music director of the philharmonic , dudamel said he hopes to spread a little of the el sistema magic in los angeles . he already has organized one youth orchestra in the run-down neighborhoods of south los angeles . those music students opened for the orchestra at the hollywood bowl . the concert also featured student musicians playing alongside jazz legend herbie hancock . cuban pianist alfredo rodriguez and bluesman taj mahal rounded out an eclectic bill designed to pull in a broad cross-section of music lovers . but it was dudamel and beethoven 's ninth symphony that brought the crowd to its feet at the concert 's end . it was a promising beginning for a man many are hailing as the savior of classical music . they hope dudamel can bring a whole new audience to symphonic music , and believe the los angeles philharmonic is the perfect podium for the young maestro . `` he fits in with this town in a lot of ways , '' swed said . `` obviously being spanish-speaking in a city where the majority of people either speak spanish or understand some spanish ... you know he fits in . the youth culture ? he is young . he is also great , which does n't hurt . ''
gustavo dudamel , known as `` the dude , '' brings beatles-like frenzy to los angeles . the venezuelan , 28 , is the new conductor of the los angeles philharmonic . his saturday debut sold out 18,000-seat hollywood bowl faster than anyone ever . los angeles times music critic calls dudamel `` a phenomenon ''
hippocampus improves learning and memory . ' dr pahan said : ` further research must be conducted to see how we could potentially maintain normal pparalpha in the brain in order to be resistant to memory loss . ' researchers found people with a lot of abdominal fat have lower levels of the nuclear regulator pparalpha in their livers and brains making them 3.6 times more likely to develop dementia . the research was published in the journal cell reports . previous research has suggested that passive smoking , sleep apnoea , drinking and taking drugs , type 2 diabetes and heart disease can all also increase a person 's risk of dementia . dementia currently affects about 800,000 people in the uk . los angeles , california -lrb- cnn -rrb- -- he got a standing ovation before the orchestra even played a single note . the amount of drugs being thrown over the fence into one prison is so high that warders have been forced to deploy a cherry picker to remove them . packages containing heroin and cannabis were cleared from the roof of hmp altcourse in liverpool - hurled there from the outside by friends of inmates who missed their intended targets . the hydraulic crane also recovered so-called ` legal highs ' as well as 22 phones , three sim cards and six chargers from the 60ft roof , contained in a total of 14 bubble-wrapped packages . officers at the jail , privately run by controversial firm g4s , disclosed the haul in an internal document , which dramatically highlights the extent of drug use among the jail 's 1,300 inmates . dave thompson , director of the category b prison , said : ` these items were thrown over the prison walls by criminals on the outside and it required a cherry picker and staff to retrieve them from inaccessible rooftops . ' altcourse , the first prison in the uk to be designed and constructed for a private operator , has been criticised for drug-related violence . gustavo dudamel has been compared to the legendary leonard bernstein by one critic . for weeks now , anticipation has been growing for the arrival of fiery young venezuelan conductor gustavo dudamel to take over the los angeles philharmonic , and the crowd could n't wait to roar its approval at his arrival . dudamel , 28 , engenders a passion among music lovers that is entirely new to the world of classical music . tickets for his saturday debut as music director of the los angeles philharmonic disappeared within minutes -- the fastest sellout in the history of the 18,000-seat hollywood bowl . `` he is a phenomenon , '' said mark swed , los angeles times music critic . `` he generates excitement the likes of which has n't come around in a very , very long time -- maybe since leonard bernstein . '' watch the exciting dudamel wield the baton '' after a three-day visit last june , chief inspector of prisons chris hardwick wrote : ` there have been 38 serious assaults in just four months before the inspection . gang issues and the availability of drugs , particularly new psychoactive substances -lsb- legal highs -rsb- were a significant factor in much of the violence . ' g4s insists that altcourse runs an effective anti-smuggling operation , and that the cherry picker is part of a ` high-visibility ' approach to show inmates they will ` root out packages from anywhere ' . ` we are committed to preventing drugs coming into our prison and we are encouraged that , at the same time as our seizures of banned substances have increased , the numbers of prisoners testing positive for them has come down , ' said mr thompson . swed was in the audience two years ago when dudamel conducted the simon bolivar youth orchestra at the walt disney concert hall , delivering a reading of beethoven 's fourth symphony that left fans delirious . `` i have n't seen that kind of reaction from a crowd since i saw the beatles at dodger stadium , '' swed said . dudamel 's face has been a common sight for months in los angeles . his billboards look down on freeway commuters . he adorns city buses . at the famous hollywood hot dog stand pink 's , there is even a dog named in his honor -- the `` dude dog , '' piled high with jalapeno peppers , guacamole and tortilla chips . while it 's not lovers . but it was dudamel and beethoven 's ninth symphony that brought the crowd to its feet at the concert 's end . it was a promising beginning for a man many are hailing as the savior of classical music . they hope dudamel can bring a whole new audience to symphonic music , and believe the los angeles philharmonic is the perfect podium for the young maestro . `` he fits in with this town in a lot of ways , '' swed said . `` obviously being spanish-speaking in a city where the majority of people either speak spanish or understand some spanish ... you know he fits in . the youth culture ? he is young . he is also great , which does n't hurt . ''
-lrb- cnn -rrb- -- he got a standing ovation before the orchestra even played a single note . the amount of drugs being thrown over the fence into one prison is so high that warders have been forced to deploy a cherry picker to remove them . packages containing heroin and cannabis were cleared from the roof of hmp altcourse in liverpool - hurled there from the outside by friends of inmates who missed their intended targets . the hydraulic crane also recovered so-called ` legal highs ' as well as 22 phones , three sim cards and six chargers from the 60ft roof , contained in a total of 14 bubble-wrapped packages . officers at the jail , privately run by controversial firm g4s , disclosed the haul in an internal document , which dramatically highlights the extent of drug use among the jail 's 1,300 inmates . dave thompson , director of the category b prison , said : ` these items were thrown over the prison walls by criminals on the outside and it required a cherry picker and staff to retrieve them from inaccessible rooftops . ' altcourse , the first prison in the uk to be designed and constructed for a private operator , has been criticised for drug-related violence . gustavo dudamel has been compared to the legendary leonard bernstein by one critic . for weeks now , anticipation has been growing for the arrival of fiery young venezuelan conductor gustavo dudamel to take over the los angeles philharmonic , and the crowd could n't wait to roar its approval at his arrival . dudamel , 28 , engenders a passion among music lovers that is entirely new to the world of classical music . tickets for his saturday debut as music director of the los angeles philharmonic disappeared within minutes -- the fastest sellout in the history of the 18,000-seat hollywood bowl . `` he is a phenomenon , '' said mark swed , los angeles times music critic . `` he generates excitement the likes of which has n't come around in a very , very long time -- maybe since leonard bernstein . '' watch the exciting dudamel wield the baton '' after a three-day visit last june , chief inspector of prisons chris hardwick was in the audience two years ago when dudamel conducted the simon bolivar youth orchestra at the walt disney concert hall , delivering a reading of beethoven 's fourth symphony that left fans delirious . `` i have n't seen that kind of reaction from a crowd since i saw the beatles at dodger stadium , '' swed said . dudamel 's face has been a common sight for months in los angeles . his billboards look down on freeway commuters . he adorns city buses . at the famous hollywood hot dog stand pink 's , there is even a dog named in his honor -- the `` dude dog , '' piled high with jalapeno peppers , guacamole and tortilla chips . while it 's not exactly venezuelan cuisine , in los angeles , there can be no surer sign that the conductor known as `` the dude '' has arrived . so where did dudamel get this musical magic ? he said at least a part of his talent is inherited . `` i started studying music when i was 4 , '' he said . `` i wanted to play trombone like my father . '' soon young gustavo entered into el sistema , venezuela 's state-financed music education program . hundreds of thousands of children have received instruments and music instruction through the nation 's massive system of youth orchestras . `` you can not imagine , '' said dudamel , `` how it changes the life of a kid if you put a violin or a cello or a flute -lsb- in his hand -rsb- . you feel you have your world . you have your life there , and it changes your life . this happened to me . '' as music director of the philharmonic , dudamel said he hopes to spread a little of the el sistema magic in los angeles . he already has organized one youth orchestra in the run-down neighborhoods of south los angeles . those music students opened for the orchestra at the hollywood bowl . the concert also featured student musicians playing alongside jazz legend herbie hancock . cuban pianist alfredo rodriguez and bluesman taj mahal rounded out an eclectic bill designed to pull in a broad cross-section of music lovers . but it was dudamel and beethoven 's ninth symphony that brought the crowd to its feet at the concert 's end . it was a promising beginning for a man many are hailing as the savior of classical music . they hope dudamel can bring a whole new audience to symphonic music , and believe the los angeles philharmonic is the perfect podium for the young maestro . `` he fits in with this town in a lot of ways , '' swed said . `` obviously being spanish-speaking in a city where the majority of people either speak spanish or understand some spanish ... you know he fits in . the youth culture ? he is young . he is also great , which does n't hurt . ''
people carry a lot fat around their middles are three and develop memory loss, research scientists people a lot abdominal fat also controls how. called pparalpha, it controls fat metabolism, but. it also resides the brain 's memory centre --. haul : the cherry picker collecting drugs the roof hmp altcourse in liverpool. controls memory learning. people carry a lot fat around their middles are three and develop memory loss. when people overweight, initially just have depleted pparalpha levels but eventually in including neurological scientists at the rush university medical centre, chicago collaboration the national institutes believe their finding an injection to improve learning people dementia dr kalipada pahan from rush university medical centre said : ` we need better fat connected memory learning so develop effective approach protect memory. ` while pparalpha deficient mice poor learning injection improves. ' dr pahan said ` further research must see we could potentially maintain normal pparalpha in in be resistant memory loss. ' researchers people a lot abdominal fat have the nuclear regulator pparalpha brains making 3.6 dementia. the research was published cell reports previous research passive smoking, drinking taking, type can also a person 's risk dementia dementia currently affects the uk. los angeles, california -lrb- cnn -- he got before the orchestra even played. the amount drugs being thrown over into one prison so warders deploy a cherry picker remove. packages containing heroin cannabis were cleared the roof hmp altcourse liverpool - hurled there the outside friends inmates missed their intended targets. the hydraulic crane also recovered so-called ` legal highs as 22 phones, three sim cards six chargers the 60ft roof, contained a total 14 bubble-wrapped packages officers at the jail, privately controversial firm g4s disclosed the haul, dramatically highlights drug use dave thompson, director the category b prison, : ` these items thrown over criminals on the outside it required a cherry picker and staff retrieve inaccessible rooftops. ' altcourse, the first prison the uk to designed a private operator, criticised drug-related violence. gustavo dudamel has compared the legendary leonard bernstein by one critic. for weeks, anticipation growing fiery young venezuelan conductor gustavo dudamel to take the los angeles philharmonic, the crowd could n't roar dudamel, 28 engenders a passion among music lovers entirely new. tickets for his saturday debut as music director the los angeles philharmonic disappeared within -- the fastest sellout the 18,000-seat hollywood bowl. `` he is a phenomenon, '' mark swed, los times music critic. `` he generates excitement the likes n't come around a very, very long time -- maybe since leonard bernstein. '' watch the exciting dudamel wield the baton '' after a three-day visit last june, chief inspector prisons chris hardwick wrote : ` there have 38 serious assaults just before the inspection. gang issues and the availability drugs, particularly new psychoactive substances -lsb- legal highs -rsb- were much. ' g4s insists altcourse runs an effective anti-smuggling operation, the cherry picker part a ` high-visibility ' approach show inmates they will ` root packages from anywhere ` we committed preventing drugs coming our prison encouraged, at our seizures of banned substances have the numbers testing them come, ' mr thompson swed was in the audience two dudamel conducted the simon bolivar youth orchestra the walt disney concert hall, delivering a reading beethoven 's fourth symphony that left fans `` i have n't that kind reaction a crowd since saw the beatles at dodger stadium, '' swed said. dudamel 's face has a common sight months in los angeles. his billboards look down freeway commuters. he adorns city buses. at the famous hollywood hot dog pink 's, there even a dog named in -- the `` dude dog, piled tortilla while it 's exactly venezuelan cuisine, in los angeles there can no surer sign the conductor known `` the dude arrived so where dudamel get this musical magic? he said at least a part his talent inherited. `` i started studying music 4, '' he. `` i wanted play trombone like my father. '' soon young gustavo entered into el sistema, venezuela 's state-financed music education program. hundreds of thousands children received instruments music instruction the nation 's massive system youth orchestras. `` you not imagine, '' dudamel, how it changes the life a kid if put a violin or or -lsb-. you feel you your world. you your life there, changes this happened. '' as music director philharmonic, dudamel said hopes spread a little the el sistema magic los angeles he already organized one youth orchestra the run-down neighborhoods south los angeles. those music students opened for the orchestra the hollywood bowl. the concert also featured student musicians playing alongside jazz legend herbie hancock. cuban pianist alfredo rodriguez and bluesman taj mahal rounded an eclectic bill designed pull in a broad cross music lovers. but dudamel and beethoven 's ninth that brought the crowd at. it a promising beginning many are hailing classical music. they hope dudamel can bring symphonic music, believe the los angeles philharmonic is the perfect podium the young maestro `` he fits this town in, '' swed said. `` obviously being spanish-speaking in a city the majority either understand some spanish... you know he fits. the youth culture? he is young. he is also great, which does n't. ''
haul in an internal document , which dramatically highlights the extent of drug use among the jail 's 1,300 inmates . dave thompson , director of the category b prison , said : ` these items were thrown over the prison walls by criminals on the outside and it required a cherry picker and staff to retrieve them from inaccessible rooftops . ' altcourse , the first prison in the uk to be designed and constructed for a private operator , has been criticised for drug-related violence . gustavo dudamel has been compared to the legendary leonard bernstein by one critic . for weeks now , anticipation has been growing for the arrival of fiery young venezuelan conductor gustavo dudamel to take over the los angeles philharmonic , and the crowd could n't wait to roar its approval at his arrival . dudamel , 28 , engenders a passion among music lovers that is entirely new to the world of classical music . tickets for his saturday debut as music director of the los angeles philharmonic disappeared within minutes -- the fastest sellout in the history of the 18,000-seat hollywood bowl . `` he is a phenomenon , '' said mark swed , los angeles times music critic . `` he generates excitement the likes of which has n't come around in a very , very long time -- maybe since leonard bernstein . '' watch the exciting dudamel wield the baton '' after a three-day visit last june , chief inspector of prisons chris hardwick wrote : ` there have been 38 serious assaults in just four months before the inspection . gang issues and the availability of drugs , particularly new psychoactive substances -lsb- legal highs -rsb- were a significant factor in much of the violence . ' g4s insists that altcourse runs an effective anti-smuggling operation , and that the cherry picker is part of a ` high-visibility ' approach to show inmates they will ` root out packages from anywhere ' . ` we are committed to preventing drugs coming into our prison and we are encouraged that , at the same time as our seizures of banned substances have increased , the numbers of prisoners testing positive for them has come down , ' said mr thompson . swed was in the audience two years ago when dudamel conducted the simon bolivar youth orchestra at the walt disney concert hall , delivering a reading of beethoven 's fourth symphony that left fans delirious . `` i have n't seen that kind of reaction from a crowd since i saw the beatles at dodger stadium , '' swed said . dudamel 's face has been a common sight for months in los angeles . his billboards look down on freeway commuters . he adorns city buses . at the famous hollywood hot dog stand pink 's , there is even a dog named in his honor -- the `` dude dog , '' piled high with jalapeno peppers , guacamole and tortilla chips . while it 's not lovers . but it was dudamel and beethoven 's ninth symphony that brought the crowd to its feet at the concert 's end . it was a promising beginning for a man many are hailing as the savior of classical music . they hope dudamel can bring a whole new audience to symphonic music , and believe the los angeles philharmonic is the perfect podium for the young maestro . `` he fits in with this town in a lot of ways , '' swed said . `` obviously being spanish-speaking in a city where the majority of people either speak spanish or understand some spanish ... you know he fits in . the youth culture ? he is young . he is also great , which does n't hurt . ''
 The article discusses the upcoming performance of Gustavo Dudamel, a young Venezuelan conductor, at the Los Angeles Philharmonic. It highlights his passion for classical music and his ability to connect with audiences. The author also mentions that Dudamel has been compared to Leonard Bernstein and that he is known for his energetic and charismatic stage presence. Additionally, the article touches on the topic of drug-related violence in Venezuela and how it affects the country's youth.