that little voice inside your head that tells you to keep eating is , in fact , simply a cluster of around 10,000 brain cells . now scientists believe they have found tiny triggers inside those cells that give rise to this ` voice ' and ruin a dieter 's good intentions . the new research , done on fish and mice , could someday lead to pills that will be able to quieten that voice or increase its volume . the research focused on pomc neurons , which are a structure called the hypothalamus , that send and receive signals to regulate appetite . on the left , images of normal hypothalamus pomc cells from a developing mouse . on the right : when the gene for the transcription factor is deleted , the cells no longer make it . the research focused on pomc neurons , which are a structure called the hypothalamus , that send and receive signals to regulate appetite . when pomc neurons are absent , or not working properly , animals and humans grow dangerously obese . the new findings show in animals that the same thing happens when certain genetic triggers inside the pomc cells are n't working . the team , led by the university of michigan , looked at how a protein called a transcription factor , and two small stretches of dna called enhancers , act as triggers for the pomc gene . all three regulate how often and when the pomc cells use the gene to create the signal molecules that then go out to the body . that little voice inside your head that tells you to keep eating is , in fact , simply a cluster of around 10,000 brain cells . now scientists believe they have found tiny triggers inside those cells that give rise to this ` voice ' ` the pomc region is a central node of the brain 's means for regulating body weight , in response to influences from the hormone leptin , ' said malcom low , a professor in the department of molecular and integrative physiology . like signal lights that show pilots the path to an airport runway , enhancers guide proteins toward the gene so it can be read . located deep inside the brain , in a structure called the hypothalamus , the cluster of pomc neurons act as a control center for feelings of fullness or hunger . they take in signals from the body , and send out chemical signals to regulate appetite and eating . when pomc neurons are absent , or not working correctly , animals and humans grow dangerously obese . the latest research show in animals that the same thing happens when certain genetic triggers inside the pomc cells are n't working . the researchers found that the two enhancers act in ways that complement one another , both encouraging the expression of the pomc gene at key times . stoke midfielder charlie adam was left with mixed emotions after scoring the best goal of his career only to end up a loser at stamford bridge . adam netted one of the most memorable goals in premier league history as he lobbed chelsea goalkeeper thibaut courtois from 66 yards on the stroke of half-time . that levelled the scores up at 1-1 , but adam 's wonder strike would end up counting for nothing as chelsea snatched a second-half winner to leave stoke nursing a third successive league loss . charlie adam -lrb- centre -rrb- lets fly from inside his own half as he scores one of the goals of his career at chelsea . thibaut courtois watches on as he is unable to stop adam 's shot from hitting the back of the net for 1-1 . stoke ended up losing 2-1 at stamford bridge as loic remy -lrb- left -rrb- scored the winner for chelsea . and while adam was understandably proud of his ` incredible ' goal , the scotland international admits the main thing for him is how the team get on and he was quick to turn his focus to next weekend 's clash with west ham . asked if it was the greatest goal of his career , adam said on stoke player : ` of course . it 's an incredible strike , it 's a nice goal to score but the important thing for us is winning the game . ` it 's three on the bounce we 've lost now , which is bad , but hopefully we can improve on that next week against west ham . ` on an individual level it 's great , but on a team performance it was ok and there 's a lot that we can improve on for next week . ' adam -lrb- second left -rrb- admitted he had mixed emotions after scoring the goal but losing the game . stoke manager mark hughes has seen his side lose in their last three premier league encounters . mice born without both of them became obese -- as if their pomc gene had been deactivated . the protein that latches on to the enhancer , called a transcription factor , is also vital . in the new pnas paper , the researchers report that the transcription factor islet 1 , encoded by the isl1 gene , plays this important role for pomc . when the researchers blocked cells of the hypothalamus from making islet 1 halfway through pregnancy , the fetal mice failed to develop any pomc cells . ` taken together , this work represents the first example of a neuron-specific gene in vertebrates where we have found both the enhancers and a shared transcription factor that control gene expression in the developing brain and then throughout the life span of the adult , ' says low . west ham are currently ninth in the standings , one spot ahead of stoke , but both teams have 42 points . adam added : ` it 's going to be a tough game . they 're in and around us as well . if we can win that will keep us in the top 10 , a few points ahead of them and hopefully we can do that with two homes games to come . ' looking to see if the same factors do the same thing in humans will be more complex -- and there may be other enhancers and transcription factors involved . but in theory , it could be possible to find drugs to increase the production of pomc gene products , or to help silence it . ` for humans , pomc regulation may be part of the equation of weight control , ' says low . ` we do n't know , but we think it likely , that it may be similar to the mouse model , where its role is like a dial , with a linear relationship between the amount of pomc expression and the degree of obesity . '
charlie adam scored stoke 's equaliser against chelsea from 66 yards out . stoke ended up losing 2-1 against chelsea at stamford bridge on saturday . the loss was stoke 's third in a row but adam backs them to return to form .
to create the signal molecules that then go out to the body . that little voice inside your head that tells you to keep eating is , in fact , simply a cluster of around 10,000 brain cells . now scientists believe they have found tiny triggers inside those cells that give rise to this ` voice ' ` the pomc region is a central node of the brain 's means for regulating body weight , in response to influences from the hormone leptin , ' said malcom low , a professor in the department of molecular and integrative physiology . like signal lights that show pilots the path to an airport runway , enhancers guide proteins toward the gene so it can be read . located deep inside the brain , in a structure called the hypothalamus , the cluster of pomc neurons act as a control center for feelings of fullness or hunger . they take in signals from the body , and send out chemical signals to regulate appetite and eating . when pomc neurons are absent , or not working correctly , animals and humans grow dangerously obese . the latest research show in animals that the same thing happens when certain genetic triggers inside the pomc cells are n't working . the researchers found that the two enhancers act in ways that complement one another , both encouraging the expression of the pomc gene at key times . stoke midfielder charlie adam was left with mixed emotions after scoring the best goal of his career only to end up a loser at stamford bridge . adam netted one of the most memorable goals in premier league history as he lobbed chelsea goalkeeper thibaut courtois from 66 yards on the stroke of half-time . that levelled the scores up at 1-1 , but adam 's wonder strike would end up counting for nothing as chelsea snatched a second-half winner to leave stoke nursing a third successive league loss . charlie adam -lrb- centre -rrb- lets fly from inside his own half as he scores one of the goals of his career at chelsea . thibaut courtois watches on as he is unable to stop adam 's shot from hitting the back of the net for 1-1 . stoke ended up losing 2-1 at stamford bridge as loic remy -lrb- left -rrb- scored the winner for chelsea . and while adam was understandably proud of his ` incredible ' goal , the scotland international admits the main thing for him is how the team get on and he was quick to turn his focus to next weekend 's clash with west ham . asked if it was the greatest goal of his career , adam said on stoke player : ` of course . it 's an incredible strike , it 's a nice goal to score but the important thing for us is winning the game . ` it 's three on the bounce we 've lost now , which is bad , but hopefully we can improve on that next week against west ham . ` on an individual level it 's great , but on a team performance it was ok and there 's a lot that we can improve on for next week . ' adam -lrb- second left -rrb- admitted he had mixed emotions after scoring the goal but losing the game . stoke manager mark hughes has seen his side lose in their last three premier league encounters . mice born without both of them became obese -- as if their pomc gene had been deactivated . the protein that latches on to the enhancer , called a transcription factor , is also vital . in the new pnas paper , the researchers report that the transcription factor islet 1 , encoded by the isl1 gene , plays this important role for pomc . when the researchers blocked cells of the hypothalamus from making islet 1 halfway through pregnancy , the fetal mice failed to develop any pomc cells . ` taken together , this work represents the first example of a neuron-specific gene in vertebrates where we have found both the enhancers and a shared transcription factor that control gene expression in the developing brain and then throughout the life span of the adult , ' says low . west ham are currently ninth in the standings , one spot ahead of stoke , but both teams have 42 points . adam added : ` it 's going to be a tough game . they 're in and around us as well . if we can win that will keep us in the top 10 , a few points ahead of them and hopefully we can do that with two homes games to come . ' looking to see if the same factors do the same thing in humans will be more complex -- and there may be other enhancers and transcription factors involved . but in theory , it could be possible to find drugs to increase the production of pomc gene products , or to help silence it . ` for humans , pomc regulation may be part of the equation of weight control , ' says low . ` we do n't know , but we think it likely , that it may be similar to the mouse model , where its role is like a dial , with a linear relationship between the amount of pomc expression and the degree of obesity . '
to create the signal molecules that then go out to the body . that little voice inside your head that tells you to keep eating is , in fact , simply a cluster of around 10,000 brain cells . now scientists believe they have found tiny triggers inside those cells that give rise to this ` voice ' ` the pomc region is a central node of the brain 's means for regulating body weight , in response to influences from the hormone leptin , ' said malcom low , a professor in the department of molecular and integrative physiology . like signal lights that show pilots the path to an airport runway , enhancers guide proteins toward the gene so it can be read . located deep inside the brain , in a structure called the hypothalamus , the cluster of pomc neurons act as a control center for feelings of fullness or hunger . they take in signals from the body , and send out chemical signals to regulate appetite and eating . when pomc neurons are absent , or not working correctly , animals and humans grow dangerously obese . the latest research show in animals that the same thing happens when certain genetic triggers inside the pomc cells are n't working . the researchers found that the two enhancers act in ways that complement one another , both encouraging the expression of the pomc gene at key times . stoke midfielder charlie adam was left with mixed emotions after scoring the best goal of his career only to end up a loser at stamford bridge . adam netted one of the most memorable goals in premier league history as he lobbed chelsea goalkeeper thibaut courtois from 66 yards on the stroke of half-time . that levelled the scores up at 1-1 , but adam 's wonder strike would end up counting for nothing as chelsea snatched a second-half winner to leave stoke nursing a third successive league loss . charlie adam -lrb- centre -rrb- lets fly from inside his own half as he scores one of the goals of his career at chelsea . thibaut courtois watches on as he is unable to stop adam 's shot from hitting the back of the net for 1-1 . stoke ended up losing 2-1 at stamford bridge as loic remy -lrb- left -rrb- scored the winner for chelsea . and while adam was understandably proud of his ` incredible ' goal , the scotland international admits the main thing for him is how the team get on and he was quick to turn his focus to next weekend 's clash with west ham . asked if it was the greatest goal of his career , adam said on stoke player : ` of course . it 's an incredible strike , it 's a nice goal to score but the important thing for us is winning the game . ` it 's three on the bounce we 've lost now , which is bad , but hopefully we can improve on that next week against west ham . ` on an individual level it 's great , but on a team performance it was ok and there 's a lot that we can improve on for next week . ' adam -lrb- second left -rrb- admitted he had mixed emotions after scoring the goal but losing the game . stoke manager mark hughes has seen his side lose in their last three premier league encounters . mice born without both of them became obese -- as if their pomc gene had been deactivated . the protein that latches on to the enhancer , called a transcription factor , is also vital . in the new pnas paper , the researchers report that the transcription factor islet 1 , encoded by the isl1 gene , plays this important role for pomc . when the researchers blocked cells of the hypothalamus from making islet 1 halfway through pregnancy , the fetal mice failed to develop any pomc cells . ` taken together , this work represents the first example of a neuron-specific gene in vertebrates where we have found both the enhancers and a shared transcription factor that control gene expression in the developing brain and then throughout the life span of the adult , ' says low . west ham are currently ninth in the standings , one spot ahead of stoke , but both teams have 42 points . adam added : ` it 's going to be a tough game . they 're in and around us as well . if we can win that will keep us in the top 10 , a few points ahead of them and hopefully we can do that with two homes games to come . ' looking to see if the same factors do the same thing in humans will be more complex -- and there may be other enhancers and transcription factors involved . but in theory , it could be possible to find drugs to increase the production of pomc gene products , or to help silence it . ` for humans , pomc regulation may be part of the equation of weight control , ' says low . ` we do n't know , but we think it likely , that it may be similar to the mouse model , where its role is like a dial , with a linear relationship between the amount of pomc expression and the degree of obesity . '
that little voice inside keep eating is, in simply a cluster around 10,000 brain cells. now scientists believe tiny triggers inside those cells give this ` voice and ruin a dieter 's good intentions. the new research, done on fish mice could someday pills will quieten that voice or increase its volume. the research focused pomc neurons, which a structure called send and regulate appetite. on the left, images normal hypothalamus pomc cells from a developing mouse. on the right : when the gene deleted, no make. the research focused pomc neurons, which a structure called send and regulate appetite. when pomc neurons absent, or not working animals and grow dangerously obese. the new findings in animals the same thing certain genetic triggers inside the pomc cells n't working. the team, led the university michigan looked a protein, and two small stretches dna called enhancers act triggers the pomc gene all three regulate how often and the pomc cells use the gene create the signal molecules then go out. that little voice inside keep eating is, in simply a cluster around 10,000 brain cells. now scientists believe tiny triggers inside those cells give this ` voice ` the pomc region is a central node the brain 's means for regulating body weight, in response influences the hormone leptin ' said malcom low,. like signal lights that show pilots the path an airport runway, enhancers guide proteins toward the gene so read. located deep the brain, in a structure the cluster pomc neurons act feelings fullness or hunger they take in signals, send chemical signals regulate appetite eating. when pomc neurons absent, or not working animals and grow dangerously obese. the latest research show in animals the same thing certain genetic triggers inside the pomc cells n't working. the researchers the two enhancers act ways complement, both encouraging the pomc gene at key times. stoke midfielder charlie adam was left mixed emotions scoring only end a loser stamford bridge. adam netted one premier league history lobbed chelsea goalkeeper thibaut courtois 66 yards on. that levelled the scores up at, adam 's wonder strike would end counting chelsea snatched to leave stoke nursing a third successive league loss charlie adam -lrb- centre lets fly from inside his own half as scores one at chelsea. thibaut courtois watches on as is unable stop adam 's shot for 1. stoke ended losing 2 stamford bridge as loic remy -lrb- left -rrb- scored chelsea. and while adam was understandably proud his ` incredible ' goal the scotland international admits the main thing for how get he was quick turn next weekend 's clash west ham. asked if the greatest goal, adam on stoke player : ` of. it 's an incredible strike, a nice goal to but the important thing for winning. ` it three on the bounce we ' lost now, which bad, hopefully improve against west ham. ` on an individual level it 's great, on a team performance was ok and there that we for next week. ' adam -lrb- second left admitted he mixed emotions scoring losing. stoke manager mark hughes has seen in their last three premier league encounters. mice born without both became obese -- as if their pomc gene deactivated. the protein latches the enhancer, called also vital. in the new pnas paper, the researchers the transcription factor islet 1, encoded the isl1 gene, plays this important role for pomc. when the researchers blocked cells of making islet 1 halfway pregnancy, the fetal mice failed any pomc cells. ` taken together, this work represents a neuron-specific gene in where we both the enhancers a shared transcription factor control and then throughout the adult, ' says low. west ham are currently ninth, one stoke, 42 points. adam added : ` it 's going. they 're in and around us as. if we win that will keep top, a few ahead them hopefully do two homes games come. ' looking see the same factors do humans will more complex -- there other enhancers and transcription factors. but in theory, possible find drugs increase pomc gene products, or help silence it ` for humans, pomc regulation may part the equation weight control ' says low. ` we do n't, think likely, similar the mouse model where its role like a dial, with a linear relationship the amount pomc expression obesity '
goal of his career only to end up a loser at stamford bridge . adam netted one of the most memorable goals in premier league history as he lobbed chelsea goalkeeper thibaut courtois from 66 yards on the stroke of half-time . that levelled the scores up at 1-1 , but adam 's wonder strike would end up counting for nothing as chelsea snatched a second-half winner to leave stoke nursing a third successive league loss . charlie adam -lrb- centre -rrb- lets fly from inside his own half as he scores one of the goals of his career at chelsea . thibaut courtois watches on as he is unable to stop adam 's shot from hitting the back of the net for 1-1 . stoke ended up losing 2-1 at stamford bridge as loic remy -lrb- left -rrb- scored the winner for chelsea . and while adam was understandably proud of his ` incredible ' goal , the scotland international admits the main thing for him is how the team get on and he was quick to turn his focus to next weekend 's clash with west ham . asked if it was the greatest goal of his career , adam said on stoke player : ` of course . it 's an incredible strike , it 's a nice goal to score but the important thing for us is winning the game . ` it 's three on the bounce we 've lost now , which is bad , but hopefully we can improve on that next week against west ham . ` on an individual level it 's great , but on a team performance it was ok and there 's a lot that we can improve on for next week . ' adam -lrb- second left -rrb- admitted he had mixed emotions after scoring the goal but losing the game . stoke manager mark hughes has seen his side lose in their last three premier league encounters . mice born without both of them became obese -- as if their pomc gene had been deactivated . the protein that latches on to the enhancer , called a transcription factor , is also vital . in the new pnas paper , the researchers report that the transcription factor islet 1 , encoded by the isl1 gene , plays this important role for pomc . when the researchers blocked cells of the hypothalamus from making islet 1 halfway through pregnancy , the fetal mice failed to develop any pomc cells . ` taken together , this work represents the first example of a neuron-specific gene in vertebrates where we have found both the enhancers and a shared transcription factor that control gene expression in the developing brain and then throughout the life span of the adult , ' says low . west ham are currently ninth in the standings , one spot ahead of stoke , but both teams have 42 points . adam added : ` it 's going to be a tough game . they 're in and around us as well . if we can win that will keep us in the top 10 , a few points ahead of them and hopefully we can do that with two homes games to come . ' looking to see if the same factors do the same thing in humans will be more complex -- and there may be other enhancers and transcription factors involved . but in theory , it could be possible to find drugs to increase the production of pomc gene products , or to help silence it . ` for humans , pomc regulation may be part of the equation of weight control , ' says low . ` we do n't know , but we think it likely , that it may be similar to the mouse model , where its role is like a dial , with a linear relationship between the amount of pomc expression and the degree of obesity . '
 The text describes Adam's incredible goal in a Premier League match, which was one of the most memorable goals in history. He scored from 66 yards out, lobbing the goalkeeper with a strike that leveled the score at 1-1. Despite Chelsea eventually winning 2-1, Adam's wonder strike will be remembered as an individual highlight.