bournemouth are set to hold off on expanding the capacity of their 12,000-seater goldsands stadium - as a tactic to help them next season . living to the ripe old age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists have said . u.s. researchers tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans and boosted the creature 's lifespan by a factor of five . the research raises the prospect of anti-ageing treatments based on genetic interactions , they said . u.s. scientists tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans -lrb- pictured -rrb- and boosted the creature 's lifespan by a factor of five . ` what we have here is a synergistic five-fold increase in lifespan , ' said lead scientist dr pankaj kapahi , from the buck institute of age research , novato , california . ` the two mutations set off a positive feedback loop in specific tissues that amplified lifespan . ` basically these worms lived to the human equivalent of 400 to 500 years . ' living to the age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists said . two mutations set off a positive feedback loop in specific tissues that enabled worms to live to the human equivalent of 400 to 500 years . while it could take years of research to . the away contingent are currently crammed into a corner of the ground between the south stand and the east stand . manager eddie howe prefers the away fans not to be behind one of the goals to give his players a psychological advantage when they are playing in front of a home crowd . bournemouth will not look to increase the capacity of their 12,000-seater goldsands stadium . premier league rules state clubs must give the away fans 10 per cent of their overall allocation . bournemouth officials are considering doubling the south stand from its current 2,500 seats to 5,000 , taking the whole capacity to just less than 15,000 . however , premier league regulations state that clubs must provide at least 10 per cent of their overall allocation of tickets for away supporters . extend humans ' lives dramatically , the study raises the prospect of . anti-ageing treatments informed by genetic interactions , according to dr . kapahi . ` in the early years , cancer researchers focused on mutations in single genes , but then it became apparent that different mutations in a class of genes were driving the disease process , ' he said . this would mean that , should bournemouth press ahead with the expansion , away fans might then have to be positioned behind one of the goals - against howe 's wishes . last year , the possibility of increasing the stadium to 18,000 by filling in all four corners was discussed , but the logistics of that make it unlikely . just to expand the south stand would cost the club # 1.8 million and , over the course of a season , they would only accrue # 900,000 in ticket sales . any construction would , therefore , be for the benefit of fans as opposed to any financial advantage . manager eddie howe is reluctant to change the position of the away fans to behind the goal . with a capacity of 12,000 bournemouth look set to have the smallest ground in the premier league . while it could take years of research to extend humans ' lives , the study raises the prospect of anti-ageing treatments informed by genetic interactions . ` the same thing is likely happening in ageing , ' he added . c. elegans , the first animal to have its whole genome -lrb- or genetic code -rrb- mapped , has been widely used in studies of ageing and lifespan . the new research , reported in the journal cell reports , involved blocking key molecules that affect the action of insulin and a nutrient signalling pathway called target of rapamycin -lrb- tor -rrb- . single mutations in the tor pathway were known to extend the lifespan of c. elegans by 30 per cent , while insulin-signalling mutations could double the amount of time they lived . adding the two together might have been expected to extend longevity by 130 per cent , but the combined impact turned out to be much greater . the research may explain why it has proved so difficult to identify single genes responsible for the long lives enjoyed by human centenarians . ` it 's quite probable that interactions between genes are critical in those fortunate enough to live very long , healthy lives , ' said dr kapahi . future research is expected to use mice to see if the same effects occur in mammals . ` the idea would be to use mice genetically engineered to have suppressed insulin signalling and then treat them with the drug rapamycin , which is well-known to suppress the tor pathway , ' dr kapahi said . earlier this year british scientists captured death spreading like a wave through the body of a worm , by studying the blue fluorescence that travels cell-to-cell until the whole organism is dead . researchers from the wellcome trust and the biotechnology and biological sciences research council -lrb- bbsrc -rrb- likened the spread of the blue glow travelling through the worm 's body to that of the grim reaper , stalking death . they believe that the research could eventually prove to be a useful model to understanding death in people and perhaps even lead to an increase in life expectancy . when individual cells die , they trigger a chemical chain reaction that leads to the breakdown of cell components and a build-up of molecular debris . the molecular mechanisms of this are reasonably well understood at a cellular level but we know much less about how death spreads throughout an organism at the end of its life . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm . the study , published in plos biology , reveals that this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . the club will have to install undersoil heating during the summer to adhere to premier league rules , something which was not a requirement in the championship . the press box , which at present separates home and away fans in the east stand , will also move to the opposite side of the pitch to be closer to the dugouts . stewards or netting would be put between supporters from either side to keep them apart during matches . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm -lrb- pictured -rrb- . this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . bournemouth only had the south stand built when they won promotion to the championship in 2013 , such has been their rapid rise up the football pyramid .
californian scientists tweaked two genetic pathways in the worm caenorhabditis elegans to amplify its lifespan . they said the worms lived to the human equivalent of 400 to 500 years . research raises the prospect of anti-ageing treatments based on genetic interactions , and the next step is to investigate if the effects occur in mice .
bournemouth are set to hold off on expanding the capacity of their 12,000-seater goldsands stadium - as a tactic to help them next season . living to the ripe old age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists have said . u.s. researchers tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans and boosted the creature 's lifespan by a factor of five . the research raises the prospect of anti-ageing treatments based on genetic interactions , they said . u.s. scientists tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans -lrb- pictured -rrb- and boosted the creature 's lifespan by a factor of five . ` what we have here is a synergistic five-fold increase in lifespan , ' said lead scientist dr pankaj kapahi , from the buck institute of age research , novato , california . ` the two mutations set off a positive feedback loop in specific tissues that amplified lifespan . ` basically these worms lived to the human equivalent of 400 to 500 years . ' living to the age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists said . two mutations set off a positive feedback loop in specific tissues that enabled worms to live to the human equivalent of 400 to 500 years . while it could take years of research to . the away make it unlikely . just to expand the south stand would cost the club # 1.8 million and , over the course of a season , they would only accrue # 900,000 in ticket sales . any construction would , therefore , be for the benefit of fans as opposed to any financial advantage . manager eddie howe is reluctant to change the position of the away fans to behind the goal . with a capacity of 12,000 bournemouth look set to have the smallest ground in the premier league . while it could take years of research to extend humans ' lives , the study raises the prospect of anti-ageing treatments informed by genetic interactions . ` the same thing is likely happening in ageing , ' he added . c. elegans , the first animal to have its whole genome -lrb- or genetic code -rrb- mapped , has been widely used in studies of ageing and lifespan . the new research , reported in the journal cell reports , involved blocking key molecules that affect the action of insulin and a nutrient signalling pathway called target of rapamycin -lrb- tor -rrb- . single mutations in the tor pathway were known to extend the lifespan of c. elegans by 30 per cent , while insulin-signalling mutations could double the amount of time they lived . adding the two together might have been expected to extend longevity by 130 per cent , but the combined impact turned out to be much greater . the research may explain why it has proved so difficult to identify single genes responsible for the long lives enjoyed by human centenarians . ` it 's quite probable that interactions between genes are critical in those fortunate enough to live very long , healthy lives , ' said dr kapahi . future research is expected to use mice to see if the same effects occur in mammals . ` the idea would be to use mice genetically engineered to have suppressed insulin signalling and then treat them with the drug rapamycin , which is well-known to suppress the tor pathway , ' dr kapahi said . earlier this year british scientists captured death spreading like a wave through the body of a worm , by studying the blue fluorescence that travels cell-to-cell until the whole organism is dead . researchers from the wellcome trust and the biotechnology and biological sciences research council -lrb- bbsrc -rrb- likened the spread of the blue glow travelling through the worm 's body to that of the grim reaper , stalking death . they believe that the research could eventually prove to be a useful model to understanding death in people and perhaps even lead to an increase in life expectancy . when individual cells die , they trigger a chemical chain reaction that leads to the breakdown of cell components and a build-up of molecular debris . the molecular mechanisms of this are reasonably well understood at a cellular level but we know much less about how death spreads throughout an organism at the end of its life . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm . the study , published in plos biology , reveals that this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . the club will have to install undersoil heating during the summer to adhere to premier league rules , something which was not a requirement in the championship . the press box , which at present separates home and away fans in the east stand , will also move to the opposite side of the pitch to be closer to the dugouts . stewards or netting would be put between supporters from either side to keep them apart during matches . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm -lrb- pictured -rrb- . this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . bournemouth only had the south stand built when they won promotion to the championship in 2013 , such has been their rapid rise up the football pyramid .
bournemouth are set to hold off on expanding the capacity of their 12,000-seater goldsands stadium - as a tactic to help them next season . living to the ripe old age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists have said . u.s. researchers tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans and boosted the creature 's lifespan by a factor of five . the research raises the prospect of anti-ageing treatments based on genetic interactions , they said . u.s. scientists tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans -lrb- pictured -rrb- and boosted the creature 's lifespan by a factor of five . ` what we have here is a synergistic five-fold increase in lifespan , ' said lead scientist dr pankaj kapahi , from the buck institute of age research , novato , california . ` the two mutations set off a positive feedback loop in specific tissues that amplified lifespan . ` basically these worms lived to the human equivalent of 400 to 500 years . ' living to the age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists said . two mutations set off a positive feedback loop in specific tissues that enabled worms to live to the human equivalent of 400 to 500 years . while it could take years of research to . the away allocation of tickets for away supporters . extend humans ' lives dramatically , the study raises the prospect of . anti-ageing treatments informed by genetic interactions , according to dr . kapahi . ` in the early years , cancer researchers focused on mutations in single genes , but then it became apparent that different mutations in a class of genes were driving the disease process , ' he said . this would mean that , should bournemouth press ahead with the expansion , away fans might then have to be positioned behind one of the goals - against howe 's wishes . last year , the possibility of increasing the stadium to 18,000 by filling in all four corners was discussed , but the logistics of that he added . c. elegans , the first animal to have its whole genome -lrb- or genetic code -rrb- mapped , has been widely used in studies of ageing and lifespan . the new research , reported in the journal cell reports , involved blocking key molecules that affect the action of insulin and a nutrient signalling pathway called target of rapamycin -lrb- tor -rrb- . single mutations in the tor pathway were known to extend the lifespan of c. elegans by 30 per cent , while insulin-signalling mutations could double the amount of time they lived . adding the two together might have been expected to extend longevity by 130 per cent , but the combined impact turned out to be much greater . the research may explain why it has proved so difficult to identify single genes responsible for the long lives enjoyed by human centenarians . ` it 's quite probable that interactions between genes are critical in those fortunate enough to live very long , healthy lives , ' said dr kapahi . future research is expected to use mice to see if the same effects occur in mammals . ` the idea would be to use mice genetically engineered to have suppressed insulin signalling and then treat them with the drug rapamycin , which is well-known to suppress the tor pathway , ' dr kapahi said . earlier this year british scientists captured death spreading like a wave through the body of a worm , by studying the blue fluorescence that travels cell-to-cell until the whole organism is dead . researchers from the wellcome trust and the biotechnology and biological sciences research council -lrb- bbsrc -rrb- likened the spread of the blue glow travelling through the worm 's body to that of the grim reaper , stalking death . they believe that the research could eventually prove to be a useful model to understanding death in people and perhaps even lead to an increase in life expectancy . when individual cells die , they trigger a chemical chain reaction that leads to the breakdown of cell components and a build-up of molecular debris . the molecular mechanisms of this are reasonably well understood at a cellular level but we know much less about how death spreads throughout an organism at the end of its life . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm . the study , published in plos biology , reveals that this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . the club will have to install undersoil heating during the summer to adhere to premier league rules , something which was not a requirement in the championship . the press box , which at present separates home and away fans in the east stand , will also move to the opposite side of the pitch to be closer to the dugouts . stewards or netting would be put between supporters from either side to keep them apart during matches . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm -lrb- pictured -rrb- . this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . bournemouth only had the south stand built when they won promotion to the championship in 2013 , such has been their rapid rise up the football pyramid .
bournemouth are hold on expanding the capacity their 12,000-seater goldsands stadium - as a tactic help next. living to 500 might a possibility if the science shown extend worms ' lives can applied, u.s. researchers tweaked two genetic pathways the tiny lab worm caenorhabditis elegans and boosted the creature 's lifespan. the research raises anti-ageing treatments based genetic interactions, they. u.s. scientists tweaked two genetic pathways tiny lab worm -lrb- pictured -rrb- boosted the creature 's lifespan. ` what we a synergistic five-fold increase lifespan, ' said lead scientist dr pankaj kapahi from the buck institute age research, novato california ` the two mutations set off specific tissues amplified lifespan. ` basically these worms lived to the human equivalent. ' living to the age 500 might a possibility if the science shown extend worms ' lives can applied humans, scientists said two mutations set specific tissues enabled worms live to the human equivalent. while it could take of. the away contingent are currently crammed a corner the ground between the south stand. manager eddie howe prefers the away fans not behind one to give his players a psychological advantage when. bournemouth will look increase the capacity their 12,000-seater goldsands stadium. premier league rules state clubs give the away fans 10 their overall allocation. bournemouth officials considering doubling the south stand from, taking the whole capacity just less however, premier league regulations state clubs provide their overall allocation tickets away supporters. extend humans ' lives dramatically, the study raises. anti-ageing treatments informed genetic interactions, according dr. kapahi. ` in the early years, cancer researchers focused mutations single genes, but then it different mutations a class driving ' he this would mean, should bournemouth press ahead the expansion, away fans might then be positioned behind one the goals - against howe 's wishes. last year, the possibility increasing the stadium to by filling in all four corners discussed, the logistics make just to expand the south stand would cost the club # 1.8 and, over, only accrue #. any construction would, therefore for the benefit fans as opposed any financial advantage. manager eddie howe is reluctant change the position the away fans to behind. with a capacity 12,000 bournemouth look set have the smallest ground the premier league. while it could take of extend humans ' lives, raises anti-ageing treatments informed genetic interactions ` the same thing is likely ageing, ' he added. c. elegans, the first animal its whole genome -lrb- or genetic code -rrb- mapped, has widely studies ageing lifespan the new research, reported the journal cell reports involved blocking key molecules affect insulin a nutrient signalling target of -lrb- tor -rrb-. single mutations the tor pathway were known extend c. elegans by 30 per, while insulin-signalling mutations could double time they lived. adding the two together might expected to extend longevity by 130 per cent, the combined impact turned the research may explain it proved identify single genes responsible the long lives enjoyed human centenarians. ` it quite probable interactions genes critical those fortunate very long, healthy lives ' said dr kapahi. future research expected use mice see mammals. ` the idea would use mice genetically have suppressed insulin signalling then treat the drug rapamycin, well suppress the tor pathway ' dr kapahi said earlier british scientists captured death spreading like a wave a worm, by studying the blue fluorescence that travels cell until the whole organism researchers from the wellcome trust and the biotechnology and biological sciences research council -lrb- bbsrc -rrb- likened the spread the blue glow travelling the worm 's body the grim reaper, stalking death. they believe the research could eventually a useful model understanding death people perhaps lead an increase. when individual cells die, trigger leads cell components a build-up molecular debris. the molecular mechanisms this are reasonably at but we know much death spreads throughout at the end. in worms, the spread death can seen easily under as a wave blue fluorescence travelling the gut. the study, published plos biology reveals this fluorescence caused a cell death pathway called necrosis and its spread throughout is dependent calcium signalling the club will have install undersoil heating during adhere premier league rules, something was a requirement the championship. the press box, which at present separates home fans in the east stand, will also move be stewards or netting would put between supporters from to keep apart during matches. in worms, the spread death can seen easily under as a wave blue fluorescence travelling the gut -lrb- pictured -rrb-. this fluorescence caused a cell death pathway called necrosis and its spread throughout is dependent calcium signalling. bournemouth only the south stand built when promotion the championship 2013, such has up.
bournemouth are set to hold off on expanding the capacity of their 12,000-seater goldsands stadium - as a tactic to help them next season . living to the ripe old age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists have said . u.s. researchers tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans and boosted the creature 's lifespan by a factor of five . the research raises the prospect of anti-ageing treatments based on genetic interactions , they said . u.s. scientists tweaked two genetic pathways in the tiny lab worm caenorhabditis elegans -lrb- pictured -rrb- and boosted the creature 's lifespan by a factor of five . ` what we have here is a synergistic five-fold increase in lifespan , ' said lead scientist dr pankaj kapahi , from the buck institute of age research , novato , california . ` the two mutations set off a positive feedback loop in specific tissues that amplified lifespan . ` basically these worms lived to the human equivalent of 400 to 500 years . ' living to the age of 500 might be a possibility if the science shown to extend worms ' lives can be applied to humans , scientists said . two mutations set off a positive feedback loop in specific tissues that enabled worms to live to the human equivalent of 400 to 500 years . while it could take years of research to . the away explain why it has proved so difficult to identify single genes responsible for the long lives enjoyed by human centenarians . ` it 's quite probable that interactions between genes are critical in those fortunate enough to live very long , healthy lives , ' said dr kapahi . future research is expected to use mice to see if the same effects occur in mammals . ` the idea would be to use mice genetically engineered to have suppressed insulin signalling and then treat them with the drug rapamycin , which is well-known to suppress the tor pathway , ' dr kapahi said . earlier this year british scientists captured death spreading like a wave through the body of a worm , by studying the blue fluorescence that travels cell-to-cell until the whole organism is dead . researchers from the wellcome trust and the biotechnology and biological sciences research council -lrb- bbsrc -rrb- likened the spread of the blue glow travelling through the worm 's body to that of the grim reaper , stalking death . they believe that the research could eventually prove to be a useful model to understanding death in people and perhaps even lead to an increase in life expectancy . when individual cells die , they trigger a chemical chain reaction that leads to the breakdown of cell components and a build-up of molecular debris . the molecular mechanisms of this are reasonably well understood at a cellular level but we know much less about how death spreads throughout an organism at the end of its life . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm . the study , published in plos biology , reveals that this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . the club will have to install undersoil heating during the summer to adhere to premier league rules , something which was not a requirement in the championship . the press box , which at present separates home and away fans in the east stand , will also move to the opposite side of the pitch to be closer to the dugouts . stewards or netting would be put between supporters from either side to keep them apart during matches . in worms , the spread of death can be seen easily under a microscope as a wave of blue fluorescence travelling through the gut of the worm -lrb- pictured -rrb- . this fluorescence is caused by a cell death pathway called necrosis and its spread throughout the organism is dependent on calcium signalling . bournemouth only had the south stand built when they won promotion to the championship in 2013 , such has been their rapid rise up the football pyramid .
 Scientists have discovered that worms can live up to 500 years if their genes are tweaked. This breakthrough could lead to anti-aging treatments and longer lifespans for humans. The research involved tweaking two genetic pathways in worms, which increased their lifespan by a factor of five. The scientists believe that this discovery could be applied to humans, potentially leading to longer lifespans and anti-aging treatments.