former husband blake fielder-civil will not receive a penny . fans tweet outrage over mitch winehouse selling daughter 's dress on four rooms , despite proceeds going to charity . men with advanced prostate cancer could benefit from a pioneering drug originally meant for women . by . clinical trials show that olaparib can delay the moment when the disease gets dangerously out of control . the drug already works for women with cancer fuelled by brca gene mutations , the defect that led to actress angelina jolie having her ovaries removed . new ` exciting ' new research suggests the drug , already used to treat women with breast cancer , could also help men with genetic faults within their prostate cancer -lrb- pictured -rrb- tumours . up to 30 per cent of men with advanced prostate cancer have tumours that have dna defects and these respond particularly well to olaparib . the london trial of olaparib , which is owned by astrazeneca , was led by researchers at the institute of cancer research and the royal marsden hospital . they found 16 out of 49 men with advanced prostate cancer responded to the drug , also known as lynparza . manchester city have decided to listen to offers for yaya toure and samir nasri this summer as the barclays premier league champions look to repair the damage of a disastrous title defence . city manager manuel pellegrini is under intense scrutiny following sunday 's 4-2 defeat by neighbours manchester united . it stopped prostate cancer growth , generating lower tumour cell counts in the blood and improved responses in medical scans . andrea magrath . published : . the drug - called olaparib - can extend the length of time that a prostate cancer patient lives with the disease without it getting worse , according to new clinical trials . olaparib is the first cancer drug to target inherited genetic mutations . it is one of the first of a new class of drugs called parp inhibitors . parp inhibitors work by blocking the cancer cell 's ability to repair damage . cancer cells that have a mutation in a brca gene rely completely on the parp protein to fix the damage . parp inhibitor drugs suppress this protein and can stop brca mutated cells from growing so they eventually die . side effects from traditional anti-cancer treatments are reduced because only cancer cells with genetic defects are targeted . most of the men who had detectable dna repair mutations had disease control lasting much longer than expected . this suggests the men most likely to benefit from the drug could be identified by testing to look for mutations . olaparib became the first of a new class of drugs called parp inhibitors to be granted approval last month for use in ovarian cancer by the european commission and the us food and drug administration . the inhibitors work by blocking the cancer cell 's ability to repair damage . cancer cells that have a mutation in a brca gene rely completely on the parp protein to fix the damage . the inhibitor drugs suppress this protein and can stop mutated cells from growing . side effects from traditional anti-cancer treatments are reduced because only tumour cells with genetic defects are targeted . professor johann de bono , who was the trial chief investigator , said : ` this opens up the exciting possibility of delivering precise treatment for advanced prostate cancer , guided by genomic testing and based on the molecular characteristics of patients ' tumours . but as the city board refuse to give up on their manager just yet the decision has been made to jettison high-profile players who the club believe have failed them . manchester city have decided to listen to offers for ivorian midfielder yaya toure this summer . the premier league champions are also open to allowing samir nasri leave the etihad stadium . toure will be made available before his value in the market dwindles . nasri , meanwhile , has barely played since his lame showing in the champions league at barcelona . defender aleksandar kolarov and striker edin dzeko are also short of admirers within the club , while midfielder james milner is out of contract this summer . toure may be difficult to sell as he earns in excess of # 1million a month . pellegrini is vulnerable but may be saved by a relatively undemanding fixture list up to the end of the season and by the fact that city 's no 1 choice to replace him , pep guardiola , is contracted to bayern munich for another year . however , city fear captain vincent kompany will miss a few weeks of the run-in with a thigh injury . 01:32 est , 29 march 2012 . | . updated : . ` it shows that parp inhibitors can be effective in a wider group of patients than had been thought -- in men as well as women , patients with mutations in their tumours as well as those with inherited mutations , and in those with a wider range of gene defects . ' the drug , olaparib , is the first cancer drug to target inherited genetic mutations . it works by blocking the cancer cell 's ability to repair damage . 02:05 est , 29 march 2012 . estate : amy winehouse left behind a fortune worth almost # 3million following her death last year . amy winehouse left behind a # 3million fortune following her death last year , it has been revealed . the singer , who was 27 , had an estate worth # 4,257,580 , which was reduced to # 2,944,554 after paid debts and taxes . the full amount will go to amy 's parents mitch and janis winehouse , as the rehab singer did not make a will . dr emma hall of the institute of cancer research said : ` we 've seen a significant improvement in the length of good quality life men can hope to live even with the most advanced prostate cancers . ` these encouraging results show that olaparib could be the next drug to add to those already available . ' the results of the trial were presented at the american association of cancer research conference in philadelphia . the national institute for health and care excellence will now decide whether olaparib should become widely available on the nhs . a decision is expected in september . dr iain frame of prostate cancer uk said : ` we want to get to a stage where every man gets the treatment he needs for his specific cancer . ' her father mitch is the administrator of her estate , according to newly-released probate documents . amy 's former husband blake fielder-civil will not receive any of the estate . winehouse passed away in july last year from alcohol poisoning at her flat in camden , with an inquest recording a verdict of misadventure . she had fought a lengthy battle with drugs and alcohol addiction . meanwhile fans of the grammy-winner took to twitter last night to voice their disapproval over mitch winehouse , 60 , appearing on channel 4 show four rooms to sell one of his daughter 's dresses , despite the proceeds going to charity . mitch hoped to raise money for the charity hopes and dreams by selling an autographed frock worn by the singer at a concert in brazil in january 2011 . in the family : with no will , the money will be left to her parents mitch and janis winehouse . ` not overtly comfortable with mitch winehouse going on #fourrooms to sell amy 's dress . just not right , ' one fan tweeted . another wrote : ` mitch winehouse just sold amy 's dress on four rooms channel four . why not the ashes mitch ? #sick ' researchers did not specify the length of time for which olaparib was able to stop advanced prostate cancer worsening . one tweeter hit back : ` love people claiming mitch winehouse is `` flogging his dead daughters dress '' when she had already donated it to charity . listen you idiots . ' criticism : fans of the singer voiced their disapproval over twitter last night at mitch appearing on four rooms to sell a dress worn by his daughter . for charity : amy autographed the frock , which she wore at a concert in rio de janeiro in january 2011 , with the intention of it going to charity . winehouse defended his actions in a statement on his own twitter feed : ` regarding the auction dress on 4 rooms on channel 4 tonight . ` amy gave that dress to hopes and dreams charity 9 months before she passed away . it is not our dress . i was asked to help with negotiations . ` so we are not selling amy 's dress . but we will sell others to raise money for kids that need help . ' hitting back : mitch defended his actions , saying he was simply carrying out his daughter 's wishes .
manchester city were beaten 4-2 by their rivals united at old trafford . the defending premier league champions will listen to offers for stars . yaya toure and samir nasri are allowed to leave the etihad this summer .
former husband blake fielder-civil will not receive a penny . fans tweet outrage over mitch winehouse selling daughter 's dress on four rooms , despite proceeds going to charity . men with advanced prostate cancer could benefit from a pioneering drug originally meant for women . by . clinical trials show that olaparib can delay the moment when the disease gets dangerously out of control . the drug already works for women with cancer fuelled by brca gene mutations , the defect that led to actress angelina jolie having her ovaries removed . new ` exciting ' new research suggests the drug , already used to treat women with breast cancer , could also help men with genetic faults within their prostate cancer -lrb- pictured -rrb- tumours . up to 30 per cent of men with advanced prostate cancer have tumours that have dna defects and these respond particularly well to olaparib . the london trial of olaparib , which is owned by astrazeneca , was led by researchers at the institute of cancer research and the royal marsden hospital . they found 16 out of 49 men with advanced prostate cancer responded to the drug , also known as lynparza . manchester city have decided to listen to offers for yaya toure and samir nasri this summer as the barclays premier league champions look to repair the damage of a disastrous title defence . city manager manuel pellegrini is under intense scrutiny following sunday 's 4-2 defeat by neighbours manchester united . it stopped prostate to replace him , pep guardiola , is contracted to bayern munich for another year . however , city fear captain vincent kompany will miss a few weeks of the run-in with a thigh injury . 01:32 est , 29 march 2012 . | . updated : . ` it shows that parp inhibitors can be effective in a wider group of patients than had been thought -- in men as well as women , patients with mutations in their tumours as well as those with inherited mutations , and in those with a wider range of gene defects . ' the drug , olaparib , is the first cancer drug to target inherited genetic mutations . it works by blocking the cancer cell 's ability to repair damage . 02:05 est , 29 march 2012 . estate : amy winehouse left behind a fortune worth almost # 3million following her death last year . amy winehouse left behind a # 3million fortune following her death last year , it has been revealed . the singer , who was 27 , had an estate worth # 4,257,580 , which was reduced to # 2,944,554 after paid debts and taxes . the full amount will go to amy 's parents mitch and janis winehouse , as the rehab singer did not make a will . dr emma hall of the institute of cancer research said : ` we 've seen a significant improvement in the length of good quality life men can hope to live even with the most advanced prostate cancers . ` these encouraging results show that olaparib could be the next drug to add to those already available . ' the results of the trial were presented at the american association of cancer research conference in philadelphia . the national institute for health and care excellence will now decide whether olaparib should become widely available on the nhs . a decision is expected in september . dr iain frame of prostate cancer uk said : ` we want to get to a stage where every man gets the treatment he needs for his specific cancer . ' her father mitch is the administrator of her estate , according to newly-released probate documents . amy 's former husband blake fielder-civil will not receive any of the estate . winehouse passed away in july last year from alcohol poisoning at her flat in camden , with an inquest recording a verdict of misadventure . she had fought a lengthy battle with drugs and alcohol addiction . meanwhile fans of the grammy-winner took to twitter last night to voice their disapproval over mitch winehouse , 60 , appearing on channel 4 show four rooms to sell one of his daughter 's dresses , despite the proceeds going to charity . mitch hoped to raise money for the charity hopes and dreams by selling an autographed frock worn by the singer at a concert in brazil in january 2011 . in the family : with no will , the money will be left to his actions , saying he was simply carrying out his daughter 's wishes .
former husband blake fielder-civil will not receive a penny . fans tweet outrage over mitch winehouse selling daughter 's dress on four rooms , despite proceeds going to charity . men with advanced prostate cancer could benefit from a pioneering drug originally meant for women . by . clinical trials show that olaparib can delay the moment when the disease gets dangerously out of control . the drug already works for women with cancer fuelled by brca gene mutations , the defect that led to actress angelina jolie having her ovaries removed . new ` exciting ' new research suggests the drug , already used to treat women with breast cancer , could also help men with genetic faults within their prostate cancer -lrb- pictured -rrb- tumours . up to 30 per cent of men with advanced prostate cancer have tumours that have dna defects and these respond particularly well to olaparib . the london trial of olaparib , which is owned by astrazeneca , was led by researchers at the institute of cancer research and the royal marsden hospital . they found 16 out of 49 men with advanced prostate cancer responded to the drug , also known as lynparza . manchester city have decided to listen to offers for yaya toure and samir nasri this summer as the barclays premier league champions look to repair the damage of a disastrous title defence . city manager manuel pellegrini is under intense scrutiny following sunday 's 4-2 defeat by neighbours manchester united . it stopped prostate rely completely on the parp protein to fix the damage . the inhibitor drugs suppress this protein and can stop mutated cells from growing . side effects from traditional anti-cancer treatments are reduced because only tumour cells with genetic defects are targeted . professor johann de bono , who was the trial chief investigator , said : ` this opens up the exciting possibility of delivering precise treatment for advanced prostate cancer , guided by genomic testing and based on the molecular characteristics of patients ' tumours . but as the city board refuse to give up on their manager just yet the decision has been made to jettison high-profile players who the club believe have failed them . manchester city have decided to listen to offers for ivorian midfielder yaya toure this summer . the premier league champions are also open to allowing samir nasri leave the etihad stadium . toure will be made available before his value in the market dwindles . nasri , meanwhile , has barely played since his lame showing in the champions league at barcelona . defender aleksandar kolarov and striker edin dzeko are also short of admirers within the club , while midfielder james milner is out of contract this summer . toure may be difficult to sell as he earns in excess of # 1million a month . pellegrini is vulnerable but may be saved by a relatively undemanding fixture list up to the end of the season and by the fact that city 's no 1 choice to replace him , pep guardiola , is contracted to bayern munich for another year . however , city fear captain vincent kompany will miss a few weeks of the run-in with a thigh injury . 01:32 est , 29 march 2012 . | . updated : . ` it shows that parp inhibitors can be effective in a wider group of patients than had been thought -- in men as well as women , patients with mutations in their tumours as well as those with inherited mutations , and in those with a wider range of gene defects . ' the drug , olaparib , is the first cancer drug to target inherited genetic mutations . it works by blocking the cancer cell 's ability to repair the most advanced prostate cancers . ` these encouraging results show that olaparib could be the next drug to add to those already available . ' the results of the trial were presented at the american association of cancer research conference in philadelphia . the national institute for health and care excellence will now decide whether olaparib should become widely available on the nhs . a decision is expected in september . dr iain frame of prostate cancer uk said : ` we want to get to a stage where every man gets the treatment he needs for his specific cancer . ' her father mitch is the administrator of her estate , according to newly-released probate documents . amy 's former husband blake fielder-civil will not receive her parents mitch and janis winehouse . ` not overtly comfortable with mitch winehouse going on #fourrooms to sell amy 's dress . just not right , ' one fan tweeted . another wrote : ` mitch winehouse just sold amy 's dress on four rooms channel four . why not the ashes mitch ? #sick ' researchers did not specify the length of time for which olaparib was able to stop advanced prostate cancer worsening . one tweeter hit back : ` love people claiming mitch winehouse is `` flogging his dead daughters dress '' when she had already donated it to charity . listen you idiots . ' criticism : fans of the singer voiced their disapproval over twitter last night at mitch appearing on four his actions , saying he was simply carrying out his daughter 's wishes .
former husband blake fielder-civil will receive a penny. fans tweet outrage mitch winehouse selling daughter 's dress on four rooms, despite proceeds. men with advanced prostate cancer could benefit a pioneering drug originally meant. by. clinical trials show olaparib delay the moment the disease gets dangerously out. the drug already works women with cancer fuelled brca gene mutations, the defect led actress angelina jolie having. new ` exciting ' new research suggests the drug, already women men genetic faults within -lrb- pictured -rrb- tumours up to 30 per cent men with tumours dna defects these respond particularly olaparib. the london trial olaparib, owned astrazeneca led researchers the institute cancer research the royal marsden hospital. they found 16 out 49 men responded, also lynparza manchester city have decided listen offers yaya toure samir nasri this as the barclays premier league champions repair of a disastrous title defence. city manager manuel pellegrini under sunday 's 4-2 defeat neighbours manchester united. it stopped prostate cancer growth, generating lower tumour cell counts improved responses medical scans andrea magrath. published :. the drug - called olaparib can extend a prostate cancer patient with without it getting, new clinical trials olaparib is inherited genetic mutations. it one first of drugs parp inhibitors. parp inhibitors work the cancer cell 's ability repair damage. cancer cells a mutation a brca gene rely completely the parp protein fix. parp inhibitor drugs suppress this protein can stop brca mutated cells so eventually. side effects from traditional anti-cancer treatments reduced because only cancer cells with genetic defects targeted. most the men had detectable dna repair mutations disease control lasting much. this suggests the men most benefit the drug could identified testing to look mutations. olaparib became of called parp inhibitors granted last ovarian cancer by the european commission and the us food and drug administration. the inhibitors work the cancer cell 's ability repair damage. cancer cells a mutation a brca gene rely completely the parp protein fix. the inhibitor drugs suppress this protein can stop mutated cells. side effects from traditional anti-cancer treatments reduced because only tumour cells with genetic defects targeted. professor johann de bono, who the trial chief investigator, : ` this opens the exciting possibility delivering precise treatment advanced prostate cancer, guided genomic testing based the molecular characteristics patients ' tumours but as the city board refuse give their manager just the decision jettison high-profile players the club failed them. manchester city have decided listen offers ivorian midfielder yaya toure this. the premier league champions are also open allowing samir nasri leave the etihad stadium. toure will made before his value in. nasri, meanwhile barely played lame showing the champions league barcelona defender aleksandar kolarov and striker edin dzeko are also short admirers within, midfielder james milner out this toure may difficult sell as he earns in # 1million. pellegrini is vulnerable but may saved a relatively undemanding fixture list up and by city 's no 1 choice, pep guardiola contracted bayern munich however, city fear captain vincent kompany will miss. 01:32 est, 29 march 2012. |. updated :. ` it shows parp inhibitors a wider group had -- in men as, patients mutations their tumours as and gene defects ' the drug, olaparib the first cancer drug target inherited genetic mutations. it works by blocking the cancer cell 's ability repair damage. 02:05 est, 29 march 2012. estate : amy winehouse left behind a fortune worth almost # 3million following last. amy winehouse left behind a # 3million fortune following her death, it the singer, 27, an estate # 4,257,580 reduced paid debts taxes the full amount will go amy 's parents mitch janis winehouse, as the rehab singer did make a will. dr emma hall of the institute cancer research said : ` we ' the length good quality life men can hope even the most advanced prostate cancers. ` these encouraging results show olaparib could the next drug add those available. ' the results presented the american association cancer research conference philadelphia. the national institute health and care excellence will now decide olaparib should become widely the nhs. a decision is expected september. dr iain frame of prostate cancer uk said : ` we want every man gets for. ' her father mitch is the administrator her estate, according newly-released probate documents amy 's former husband blake fielder-civil will receive of the estate. winehouse passed july last from alcohol poisoning her flat camden, with recording a verdict. she had fought a lengthy battle drugs. meanwhile fans the grammy-winner took last voice mitch winehouse, 60, appearing channel show four rooms sell one his daughter 's dresses, despite the proceeds mitch hoped raise hopes and by selling an autographed frock worn the singer brazil january. in the family : with no will, the money left mitch janis winehouse ` not overtly comfortable mitch winehouse going #fourrooms to sell amy 's dress. just not right, ' one fan tweeted another wrote : ` mitch winehouse just sold amy 's dress on four rooms channel four. why not the ashes mitch? #sick ' researchers did specify the length for olaparib was able stop advanced prostate worsening. one tweeter hit back : ` love people claiming mitch winehouse `` flogging his dead daughters dress '' when had already donated it. listen you idiots. ' criticism : fans the singer voiced twitter last at mitch appearing four rooms to sell a dress worn his daughter. for charity : amy autographed the frock, which rio de janeiro january with the intention it going winehouse defended his own twitter feed : ` regarding the auction dress on 4 rooms on channel tonight. ` amy gave that dress hopes and charity 9 passed. it our dress. i was asked help negotiations. ` so we selling amy 's dress. but we will sell others raise kids that. ' hitting back : mitch defended, simply carrying his daughter 's wishes.
to replace him , pep guardiola , is contracted to bayern munich for another year . however , city fear captain vincent kompany will miss a few weeks of the run-in with a thigh injury . 01:32 est , 29 march 2012 . | . updated : . ` it shows that parp inhibitors can be effective in a wider group of patients than had been thought -- in men as well as women , patients with mutations in their tumours as well as those with inherited mutations , and in those with a wider range of gene defects . ' the drug , olaparib , is the first cancer drug to target inherited genetic mutations . it works by blocking the cancer cell 's ability to repair damage . 02:05 est , 29 march 2012 . estate : amy winehouse left behind a fortune worth almost # 3million following her death last year . amy winehouse left behind a # 3million fortune following her death last year , it has been revealed . the singer , who was 27 , had an estate worth # 4,257,580 , which was reduced to # 2,944,554 after paid debts and taxes . the full amount will go to amy 's parents mitch and janis winehouse , as the rehab singer did not make a will . dr emma hall of the institute of cancer research said : ` we 've seen a significant improvement in the length of good quality life men can hope to live even with the most advanced prostate cancers . ` these encouraging results show that olaparib could be the next drug to add to those already available . ' the results of the trial were presented at the american association of cancer research conference in philadelphia . the national institute for health and care excellence will now decide whether olaparib should become widely available on the nhs . a decision is expected in september . dr iain frame of prostate cancer uk said : ` we want to get to a stage where every man gets the treatment he needs for his specific cancer . ' her father mitch is the administrator of her estate , according to newly-released probate documents . amy 's former husband blake fielder-civil will not receive any of the estate . winehouse passed away in july last year from alcohol poisoning at her flat in camden , with an inquest recording a verdict of misadventure . she had fought a lengthy battle with drugs and alcohol addiction . meanwhile fans of the grammy-winner took to twitter last night to voice their disapproval over mitch winehouse , 60 , appearing on channel 4 show four rooms to sell one of his daughter 's dresses , despite the proceeds going to charity . mitch hoped to raise money for the charity hopes and dreams by selling an autographed frock worn by the singer at a concert in brazil in january 2011 . in the family : with no will , the money will be left to his actions , saying he was simply carrying out his daughter 's wishes .
 The text appears to be discussing various topics, including sports, cancer research, and personal stories. There is no clear central theme or focus, but rather a collection of unrelated paragraphs.

Here's a rewritten version with a focus on sports:

Pep Guardiola has been contracted by Bayern Munich for another year. However, City captain Vincent Kompany will miss a few weeks due to a thigh injury. Meanwhile, in cancer research, Olaparib is the first drug to target inherited genetic mutations. It works by blocking the cancer cell's ability to repair damage. In other news, Amy Winehouse left behind a fortune worth almost £3 million following her death last year. Her father Mitch Winehouse did not make a will. Dr. Emmet Hall of the Institute of Cancer Research said that we've seen significant improvement in good quality life for men who can hope to live even with advanced prostate cancer. The singer, who was 27, had an estate worth £4,257,580, which was reduced to £2,944,554 after debts and taxes. Her parents, Mitch and Janis Winehouse, will now decide what to do with the estate. A decision is expected in September.