text: Yo, morbidity and mortality, thalassemia's reality,
  Iron overload cardiomyopathy, causin' calamity.
  Iron-induced cardiac Ca2+ dysregulation,
  A core process in heart failure, no hesitation.
  
  Deferiprone and N-acetylcysteine,
  Cardioprotective, keepin' hearts clean.
  But their effect on thalassemic mice,
  Cardiac Ca2+ transients, still a rollin' dice.
  
  Iron overload induced in the mice,
  Wild-type and heterozygous, ain't nothin' nice.
  High-iron diet, messin' with their health,
  Then came the treatments, testing for the wealth.
  
  DFP, NAC, or both combined,
  Reducin' plasma iron, they're on the grind.
  Cardiac iron concentration, goin' down,
  Systolic dysfunction, no longer wearin' the crown.
  
  DFP and NAC, they had similar might,
  In both WT and HT, bringin' the light.
  Reducin' CIC, bringin' relief,
  Cardiac Ca2+ transients, showin' decrease.
  
  But the combo of DFP and NAC,
  Outperformed the rest, that's a fact.
  Reduced CIC, restored the flow,
  Cardiac Ca2+ back in the know.
  
  Protein expression, no change was seen,
  DFP and NAC, keepin' it clean.
  Iron chelator-antioxidant, synergistic effect,
  Improvin' cardiac contractility, connectin' the sect.
  
  So we got the evidence, first of its kind,
  Combining therapies, leavin' no one behind.
  Cardiac [Ca2+], in homeostasis it be,
  Improvin' the hearts, for all to see.