text: Yo, check it out, here's the rap rendition
  Talkin' 'bout clinical trials, pay attention
  Data monitoring committees, they oversee
  Checkin' safety, efficacy, that's how it be
  
  Ethical concerns, logistical too
  They monitor data, that's what they do
  To see if the treatment's workin' fine
  New experimental, it's on the line
  
  Group sequential methods, that's the way
  Formalized monitorin' comes into play
  Regulatory agencies, they intervene
  Says primary analyses, gotta be clean
  
  Independent review committee, that's the crew
  Their judgment matters, they gotta review
  But there's a time lag, it's a delay
  Gettin' assessments from the IRC, hey
  
  Missing data problem, that's the deal
  Surrogate measure, we gotta reveal
  For interim decisions, monitorin' too
  Missingness mechanisms, we'll go through
  
  Binary endpoints, that's what we see
  Missing completely at random, it could be
  IRC's measurement, it affects the game
  Statistical tools, that's how we aim
  
  So in this paper, we bring the heat
  With tools to monitor, keep it sweet
  Group sequential trials, missin' IRC's view
  We got the methodology, we'll see it through!