text: Yo, check it out, I got a story to tell
  'Bout cancer cells and how they rebel
  They develop resistance, it's a clinical plight
  Messin' up cancer chemotherapy, it ain't right
  
  We got this thing called multidrug resistance (MDR)
  It's a problem, man, causing failure for sure
  P-glycoprotein (P-gp), it's overexpressed
  And inhibitor of apoptosis proteins (IAPs), they're a mess
  
  These mechanisms, they're the common ones
  In MDR cancer cells, where the battle's begun
  But the connection between IAPs and P-gp is unknown
  So we did some research, we went full-blown
  
  We checked the levels of Survivin and XIAP
  How they interact with P-gp, that's the rap
  In MDR cancer cells, like KBv200 and MCF-7/Adr
  P-gp, XIAP, and Survivin, they all went far
  
  They overexpressed, resisting the drugs we gave
  Doxorubicin, docetaxel, vincristine, they misbehave
  Unlike their parental cells, KB and MCF-7
  These resistant cells, they went straight to heaven
  
  We tried upregulation, transfected some genes
  Survivin or XIAP, in different scenes
  But P-gp expression, it ain't affected, man
  No change in these resistant cells, it's part of the plan
  
  Then we tried downregulation, using siRNA
  Survivin or XIAP, we're gettin' closer, yeah
  But P-gp expression, it remained the same
  These resistant cells, they playin' their game
  
  Immunoprecipitation, we did the test
  Survivin or XIAP, they didn't bind, no jest
  So in conclusion, what did we find?
  Survivin and XIAP don't mess with P-gp, they ain't aligned
  
  So that's the story, the tale we unfold
  Survivin, XIAP, and P-gp, they hold
  But they don't directly interact, my friend
  In MDR cancer cells, that's the message we send