text: Yo, check it out, I'm 'bout to drop some knowledge,
  Talkin' 'bout leukemia inhibitory factor (LIF) in the college.
  Bone development and growth, that's what we discussin',
  LIF got functions in that, ain't no frontin'.
  
  In the growth plate and neonate bones, listen close,
  LIF deficiency got the VEGF levels on the rose.
  Blood vessel formation, it be enlarged and grand,
  Them "giant" osteoclasts, they destroyin' the land.
  
  Mineralized regions of the growth plate, they gettin' destroyed,
  LIF deficiency got them neonatal bones deployed.
  But down below, osteoblasts be makin' moves,
  Woven bone, they be producin' in large grooves.
  
  Now let's shift gears, talk 'bout bone in adults,
  Remodelin' phase, where changes occur, no insults.
  Osteoclast formation, LIF deficiency don't affect,
  But osteoblasts, they suffer, yo, that's a fact.
  
  Impaired formation and function, osteopenia's the result,
  LIF deficiency messin' up bone, that's the adult's fault.
  And yo, LIF be promotin' osteoblast commitment,
  But in LIF null mice, marrow adipocytes be gettin' lit.
  
  Adipocytic differentiation, it be delayed by LIF treatment,
  LIF got control, it's the bone's achievement.
  Vascular size and osteoclasts, LIF got 'em in check,
  In cartilage to bone transition, LIF be the connect.
  
  But there's another pathway, LIF-dependent, separate,
  Regulatin' osteoblasts and adipocytes, it's great.
  LIF got the power, it be callin' the shots,
  In bone remodeling, it's pullin' all the plots.