text: Yo, check it out, listen up, here's the scoop,
  Peroxisome proliferator-activated receptor, that's PPARδ, no time to regroup.
  Implicated in the carcinogenesis of cancer types,
  But do PPARδ ligands fight cancer's grip, that's what my rhyme describes.
  
  We showed PPARδ's role in melanoma cell migration and invasion,
  Snail expression goes up, it's a bomb detonation.
  GW501516, the specific ligand, activates PPARδ's might,
  Boosts migration and invasion in A375SM, out of sight.
  
  But hold up, A375P cells don't feel the same,
  Only the highly metastatic A375SM feels the flame.
  PPARδ's effects on A375SM are clear,
  Snail expression goes up, E-cadherin takes a dive, no fear.
  
  Concentration and time, they both play a role,
  Snail mRNA and protein levels rise, it's a story to unfold.
  GW501516 in A375SM cells, it's the key,
  Snail's on the rise, but in A375P, it's not what you see.
  
  Interfering RNA against PPARδ, it's like a break,
  GW501516's effects reduced, no more shake.
  PPARδ mediates the power of GW501516 in the game,
  It's all about the genes, that's the aim.
  
  SK-MEL-2 and SK-MEL-5, they join the show,
  Snail mRNA and protein levels rise, ready to blow.
  Invasive and migratory potential, they're all in sync,
  PPARδ brings the fire, it's the aggressive phenotype we think.
  
  So there you have it, PPARδ and Snail on the rise,
  Fueling the aggressive behavior, no compromise.
  Melanoma cells, they dance to this rap,
  PPARδ's role in cancer, that's the trap.