text: Yo, check it out, I got a story to tell
  'Bout a quinazolinedione-based ligand, oh, it's swell
  This multidisciplinary approach, yeah, it's prime
  Gonna decrease the flexibility of the substrate-covering line
  
  We talkin' 'bout type II dehydroquinase, don't you know?
  From Helicobacter pylori, it's gotta go
  This enzyme, it's crucial for the bacterium's survival
  In the biosynthesis of aromatic amino acids, it's vital
  
  We start with a computer-aided fragment-based game
  ALTA protocol, that's its name
  Identify the aromatic fragments, block the interface pocket
  Separatin' the enzyme subunits, don't you knock it
  
  Chemical modification, that's the next phase
  Olefin cross-metathesis, we set ablaze
  Seebach's self-reproduction of chirality, yeah, it's fly
  Gonna develop a quinazolinedione derivative, oh my
  
  Disable that catalytic loop plasticity, that's the aim
  Crucial for the enzyme's catalytic cycle, it's the same
  Molecular dynamics simulations, here we go
  The ligand forces the loop, puts it in a show
  
  Inappropriate arrangement for catalysis, this is real
  Strong interactions with catalytic tyrosine, it can feel
  Expels the essential arginine from the active site
  This ligand's got power, gonna put up a fight
  
  So there you have it, the science in a rap
  A quinazolinedione-based ligand, causin' a trap
  Multidisciplinary approach, breakin' it down
  In the world of enzymes, it wears the crown