text: Yo, check it out, we went deep in the lab
  Investigated argirein and rhein, no gab
  On rat paw edema caused by complete adjuvant
  Comparing it to ibuprofen, we got the slant
  
  Hypothesized that inflammation's to blame
  Upregulating ATF6, that's the game
  Chaperone for ER stress, it's on the rise
  p66Shc, modulating oxidative ties
  
  NADPH oxidase subunits, p22phox and gp91phox
  Inflamed tissues, they're the ones who rock
  Measured biomarkers, watched the swelling grow
  Primary edema hit fast, yeah, it's a blow
  
  Secondary inflammation came two weeks later
  Cytokines up, like an escalator
  ATF6, p66Shc, p22phox, gp91phox
  MMP-2 on the scene, like a boss
  
  p-Akt/Akt ratio, it was rising high
  In the afflicted paw, no need to lie
  But argirein and rhein, they came to save the day
  Just like ibuprofen, keeping inflammation at bay
  
  ER stress, p66Shc, and Akt all in the mix
  Causing inflammation, what a tricky fix
  But our supermolecule duo, they held their ground
  Argirein and rhein, their effects profound
  
  So when it comes to fighting inflammation, don't you fret
  Argirein and rhein got your back, you bet
  Comparable to ibuprofen, they're the real deal
  Suppressing those biomarkers, and that's the appeal