text: Yo, listen up, I got a tale to tell,
  'Bout them HOT regions, man, they ringin' bells.
  Transcription factors bindin', holdin' it tight,
  Recent modENCODE reports, shinin' bright.
  
  Drosophila melanogaster, we put 'em to the test,
  108 HOT regions, we ain't takin' a rest.
  Transgenic embryos, reporters on the spot,
  Turns out 102 of 'em, they hella hot!
  
  Enhancers in action, durin' embryogenesis,
  Spatial and temporal patterns, they show no nemesis.
  Like important genes, they got the same flow,
  Developmental expression, let it all show.
  
  Nearby genes gettin' activated, no doubt,
  HOT regions makin' 'em shout it out loud.
  Endogenous gene expression, they gotta have it,
  Bacterial artificial chromosome transgenesis, we grab it.
  
  HOT enhancers got a signature that's unique,
  Vielfaltig, Zelda, they're the ones we seek.
  Trithorax-like, GAGA, they're in the mix,
  Enriched motifs in the sequence, that's the fix.
  
  Predictin' HOT regions, just from DNA alone,
  Cis-regulatory magic, like it's carved in stone.
  So remember this rap, 'bout the HOT regions we find,
  In the world of transcription, they're one of a kind.