text: Yo, check it out, I got some data to share,
  'Bout estradiol and histamine, let me make it clear.
  In the rat uterus, estradiol takes the stage,
  Boostin' histamine formation, settin' off a rage.
  
  Histidine decarboxylase, it's the enzyme in action,
  Estradiol's induction causin' a reaction.
  Histamine activates adenylate cyclase,
  Cyclic 3',5'-AMP starts to amass with grace.
  
  Phosphorylation of chromatin proteins takes place,
  Glycolytic enzymes gettin' in the race.
  Estradiol's effects mediated, no doubt,
  A cascade amplifying, that's what it's about.
  
  Histamine acts like a mediator between cells,
  So let's investigate where these substances dwell.
  Estradiol, histamine, and cyclic 3',5'-AMP,
  Their distribution in uterine cells, let's go and stamp.
  
  Autoradiography reveals the truth we seek,
  Nuclei of myometrium cells bindin' estradiol, unique.
  Histamine, it's chillin' in the cytoplasm, no fuss,
  While cyclic 3',5'-AMP, capillary endothelium is a must.
  
  Estradiol's mediators spread their effect wide,
  Different cell types, together they collide.
  A multicellular system, functionally aligned,
  Estradiol's power, yo, it's one of a kind.