text: Yo, listen up, I got a story to tell,
  'Bout these diseases that ring the death knell.
  Transmissible spongiform encephalopathies, TSEs they're named,
  Prion diseases, infectious and they're no game.
  
  In humans, we got Creutzfeldt-Jakob disease, CJD for short,
  Gerstmann-Sträussler-Scheinker syndrome, Fatal Familial Insomnia, they can't be ignored.
  Kuru's another one that's part of the crew,
  Neurodegenerative disorders, they'll take you.
  
  Now let's talk 'bout animals, they ain't immune,
  Scrapie in sheep and goats, yo, it's a gloom.
  Bovine spongiform encephalopathy, BSE in cattle,
  Chronic wasting disease, CWD's no battle.
  
  Here's the deal, a critical event takes place,
  Abnormal PrP(Sc) protein accumulates with grace.
  It folds all wrong in the central nervous system,
  Protease-resistant isoform, it ain't no prism.
  
  PrP(Sc), also known as rPrP(Sc), PrP27-30,
  It's the main marker, the key to this dirty journey.
  Used for diagnosis, it's the reference method,
  Prion diseases, man, they gotta be detected.
  
  Therapeutic strategies, they've been tried,
  Diminishing PrP(Sc) levels, they're on the ride.
  Some success, some failure, it's a mixed bag,
  But we ain't giving up, we'll keep pushing like a drag.
  
  Now listen close, 'cause here's the alternative,
  Small molecules inducing PrP(Sc) oligomerative.
  Thienyl pyrimidine compounds, they got the power,
  Triggering PrP(Sc) oligomerization every hour.
  
  Virtual and cellular screenings, we went the distance,
  Found these compounds, trapping prion infectivity's existence.
  It's a whole new approach, breaking the mold,
  In the fight against prion diseases, we're bold.