text: Yo, listen up, I got some facts to drop 
  'Bout amino acid substitutions, it's a real hip hop 
  In D. lebanonensis ADH, they happen unique 
  In the NAD(+)-binding domain, they cause a tweak 
  
  These substitutions, they affect residues 
  Found in all species, except this one that's new 
  We fixed this problem with some science, we did 
  We made two mutants, Ala13Gly and Asn56Thr, no kid 
  
  We put this enzyme in E. coli to express 
  The retromutants we made, we put them to the test 
  And the results we got were really kind of fly 
  Increased catalytic efficiency and thermal stability, oh my! 
  
  So, it's clear that with site-directed mutagenesis 
  We can improve wild-type D. lebanonensis ADH, that's the genesis