text: Yo, check it out, here's the rap rendition
  Talkin' 'bout PI3Ks, the lipid kinases on a mission
  They produce phosphoinositides, phosphorylated at position 3
  In the inositol ring, that's where they be
  
  Three classes of PI3Ks, let me break it down
  Class I PI3Ks, at the plasma membrane they're found
  D. melanogaster and C. elegans keep it simple and tight
  They got one form of class I PI3K, that's their delight
  
  But vertebrates, they got four, yeah, they goin' wild
  Four class I PI3Ks, different genes, they're compiled
  Duplication of these genes, it's like a synchronized dance
  Coordinated multi-organ development, they enhance
  
  Now let's talk about PI3Kα and PI3Kβ, they're everywhere
  Ubiquitously expressed, showin' no fear
  Similar putative protein domains, they share the same groove
  And they both got that PI(4,5)P2 lipid substrate they move
  
  Fifteen years since their inhibitors and mouse models emerged
  Selective inhibition, their function was submerged
  Now we review the knowledge, what have we learned?
  About the redundant and selective roles that they earned
  
  Recent data show they ain't just redundant, they collaborate
  Organ-specific and context-specific cues, they integrate
  They orchestrate organ development, physiology, and disease
  Isoform-selective inhibitors, in clinics, they please
  
  So remember, PI3Ks, they're the real deal
  Isoform-selective inhibitors, that's the deal you can feel
  In the world of biology, they hold the key
  To understanding and treating diseases, can't you see?