text: Yo, check it out, let me break it down for you real quick
  Chlorpromazine, CPZ, a dopamine antagonist, slick
  Used for schizophrenia therapy, that's the main game
  But it's got potential in other fields, let me explain
  
  Cancers, heritable autism disorder, prion diseases too
  Chlorpromazine might inhibit proteins, it's true
  Now we got these new variants, listen to this
  Double or triple substitutions, they don't miss
  
  I56F/L39A, F105L/L39A, and a few more
  Changing the shape of the binding pocket, hardcore
  We ran some tests, crystallography on the scene
  Circular dichroism, isothermal titration, know what I mean?
  
  CD spectra and crystal structures, everything's in check
  Mutations don't mess with the overall protein wreck
  But compared to the wild type, there's some shift
  I56F lowers stability, F105L gives a temperature lift
  
  These new variants, they ain't playing it cool
  They got an affinity for chlorpromazine, that's the rule
  Range is 4.2 to 15.4 times ten to the power of three
  Molar binding constant, that's how it be
  
  CD spectra and crystal structures, they reveal
  The binding pocket's shape, it's got appeal
  Only one chiral conformer, that's the deal, no debate
  (aR)-CPZ bonds with I56F, (aS)-CPZ takes F105L's bait