text: Yo, check it out, I got a story to tell
  'Bout the Mesenteric lymph node, you know it well
  In the gut-associated lymphoid tissue it resides
  Inducing oral tolerance, it's got the vibes
  
  But hold up, y'all, we got some questions to raise
  Immunological characteristics in a haze
  So we dug deep, we investigated the scene
  Comparing MLN CD4(+) T cells to the spleen
  
  Hypo-responsiveness, that's what we found
  MLN CD4(+) T cells, they don't make a sound
  Hypo-proliferative, low Th1-type cytokines
  Antigen or CD3/TCR stimulation, no signs
  
  It ain't about the regulatory T cell crew
  CD4(+)CD25(+) and CD4(+)Foxp3(+), it ain't true
  Apoptotic population ain't the cause, my friend
  MLN CD4(+) T cells got a different trend
  
  T cell:APC conjugation, that's where it's at
  Deformity in MLN CD4(+) T cells, that's a fact
  TCR signaling molecules, they ain't right
  CD3zeta, PLC-gamma1, PKC-theta taking flight
  
  Zap70 and ITAMs, they're reduced too
  Phosphorylation ain't happening, it's all askew
  But CD3zeta, that's the one standing tall
  CD3/CD28 costimulation, it can recall
  
  Restoring CD3zeta expression, that's the key
  Reversing the anergic state, setting cells free
  CD4(+) T cells in the MLN, they matter, you see?
  Critical for mucosal tolerance, maintaining harmony
  
  So that's the scoop, the story we unfold
  MLN CD4(+) T cells, their tale is bold
  Reduced CD3zeta expression and TCR signaling flaws
  Mediating anergy, but now we know the cause