text: Yo, listen up, I got a story to tell,
  'Bout Smad7, a regulator that rings the bell.
  In the TGF-β pathway, it's got control,
  Forming feedback loops, it's takin' its toll.
  
  But hold up, there's more to this tale,
  Smad7 got a function that's proapoptotic, it prevails.
  In this study, we showed its power,
  As a negative regulator of survival protein, HO-1, it devours.
  
  Cisplatin-resistant cells, A549 in the mix,
  HO-1 protein level, it was raised, that's the fix.
  Blockade of HO-1, made 'em vulnerable to apoptosis,
  Now that's a twist, a lethal diagnosis.
  
  Smad7 stepped in, decreased HO-1's expression,
  Enzymatic activity, it brought repression.
  Akt's activity took a hit, it went down,
  Adenovirus with active Akt, it turned the frown.
  
  The inhibitory effects of Smad7 got reversed,
  HO-1 was back, survival pathway dispersed.
  A549 cells became sensitive to cisplatin's wrath,
  HO-1 and Akt inhibition walked the path.
  
  So, let's take a moment to comprehend,
  Targeting Smad7, a strategy to transcend.
  Drug-resistance in cancer therapy, it might defy,
  Smad7's the key, let's give it a try.