text: MicroRNAs, miRNAs, miRs, they regulate the game,
  Cellular processes, tumorigenesis, it's all the same.
  Hepatocellular carcinoma, HCC in the mix,
  Dysregulation of miRNAs, that's the fix.
  
  Chemotherapy resistance, drug sensitization too,
  But the mechanisms, they're still askew.
  Multiple drug resistance, a barrier so tall,
  Treating advanced HCC, we hit a wall.
  
  In this study, miR-101 takes the stage,
  Downregulated in HCC, like a suppressed sage.
  Transfection of miR-101, a power move,
  Enhancing doxorubicin's cytotoxic groove.
  
  Doxorubicin's accumulation, it remains intact,
  But miR-101 boosts apoptosis, that's a fact.
  Bioinformatics predicts the target in sight,
  Mcl-1's 3'-untranslated region, it's gonna ignite.
  
  Luciferase reporter assay, the evidence is clear,
  MiR-101 directly targets Mcl-1, it's here.
  Transfection of Mcl-1 plasmid, it intervenes,
  Apoptosis inhibition, the doxorubicin scene.
  
  In conclusion, miR-101 brings the heat,
  A negative regulator of Mcl-1, it's elite.
  Combining with doxorubicin, a novel play,
  Treating HCC, a new approach today.