e10510d2__Information___Medicine_Online_odifications_for_Skin_Toxicity_Suggested_Dose_Modification
[Skin Toxicity Grade] Grade 2: Painful erythema and swelling of the hands or feet and/or discomfort affecting the patient's normal activities [Occurrence] 1st occurrence [Suggested Dose Modification] 
Continue treatment with NEXAVAR and consider topical therapy for symptomatic relief If no improvement within 7 days, see below
NEXAVAR(sorafenib)tablets 200 mg Drug Information - Medicine Online
Suggested Dose Modification