eaa777cd_CER_Inventory___CER_Inventory__Category
[Agency] NIH [Project Title] COMPARATIVE EFFECTIVENESS OF MEDICATIONS USED IN CONGENITAL HEART SURGERY [Institution] DUKE UNIVERSITY [Amount] $450,815 [Summary] This application will focus on investigating medications in 3 therapeutic areas: anti-fibrinolytic agents used during surgery, afterload reduction in the post-operative setting, and peri-operative antibiotic prophylaxis. Our overall hypothesis is that the linking and analysis of existing large pediatric data sources can address many of these current knowledge gaps and provide robust data in 3 specific areas: 1) identifying current practice patterns and variation in peri-operative care of children undergoing congenital heart surgery; 2) performing observational comparative effectiveness studies which will provide data on efficacy and safety, as well as sample sizes, event rates, and drug effect to be used in planning subsequent trials; 4) establishing a network of sites willing to participate in subsequent studies. [Completion/ Closing Date] 09/02/2010 [Link] link [Category] 
Medical treatments, items and services
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