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[Test Name and Number] RhD Antigen (RhD) Genotyping 0051368 Method: Polymerase Chain Reaction/Fluorescence Monitoring [Limitations] Most rare mutations in the RHD gene (ie, missense, nonsense, insertions, gene fusion, or small deletions) will not be detected by this test In these cases, the sample may be misinterpreted as being RhD-positive (false-positive) Rare diagnostic errors may result from primer-site mutations Bloody amniotic fluid specimens may give false-negative results due to maternal-cell contamination [Follow Up] Fetuses predicted to be unaffected should continue to be monitored by noninvasive means [Recommended Use] 
Determine paternal RHD genotype (heterozygous or homozygous) in phenotypically positive individual when reproductive partner has clinically significant alloantibody Include father’s ethnicity and RhD phenotyping result with order If father of pregnancy is homozygous for RHD allele, all of his offspring can be assumed to be RhD-positive, negating the need for fetal RHD testing Determine fetal genotype when mother has clinically significant alloantibody AND father is heterozygous for RHD or not available for testing Include parent’s ethnicity and RhD phenotyping result with order Clinical sensitivity ≥98%
Hemolytic Disease of the Newborn - ARUP Consult, Your Online Lab Test Resource
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