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[Agency] NIH [Project Title] SPIN-LABELED PEPTIDE ANTIBIOTICS [Institution] MEDICAL COLLEGE OF WISCONSIN [Amount] $328,134 [Summary] The prevalence of multi-drug resistant (MDR) infections is one of the most serious problems in health care today, both in the United States and worldwide, leading to increased treatment costs and a growing incidence of treatment failure. There is a critical need for the development of new antibiotics, and in particular for new classes of compounds that target non-traditional sites other than cell-wall synthesis and the bacterial ribosome. Antimicrobial peptides, which display remarkable efficacy against a broad spectrum of pathogens, including those resistant to conventional antibiotics, offer a novel approach to the treatment of drug-resistant infections. Developing a more complete understanding of the interactions of antimicrobial peptides with their target cells will enhance our ability to design and develop more effective peptide and peptidomimetic antibiotics. [Completion/ Closing Date] 09/02/2010 [Link] link [Category] 
Medical treatments, items and services
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