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[Agency] NIH [Project Title] COMPARISON OF DEPRESSION INTERVENTIONS AFTER ACUTE CORONARY SYNDROME (CODIACS) [Institution] COLUMBIA UNIVERSITY HEALTH SCIENCES [Amount] $2,155,291 [Summary] Propose a multicenter feasibility/vanguard project comparing the effectiveness of two interventions for post-ACS depression. The project will culminate in a well-designed, well-organized multicenter Phase III clinical trial. Aim 1) To determine the feasibility and effectiveness of the COPES intervention at other sites by conducting a 5-site RCT comparing the COPES intervention to standard care for depression in post-ACS patients, and to obtain estimates of yield, acceptance, and retention for use in planning a large phase 3 clinical trial. Aim 2) To propose a Phase III single-blind, parallel-group, comparative effectiveness RCT for post-ACS patients, testing whether Enhanced depression care results in fewer major adverse cardiovascular events (MACE - recurrent myocardial infarction, hospitalization for unstable angina with documented CHD) and lower all-cause mortality (ACM) across an average 2 year follow-up, compared to Standard of depression care. [Completion/ Closing Date] 08/02/2010 [Link] link [Category] 
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