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[0] Wilson, Christopher [1] Immune Function and Biodefense in Children, Elderly, and Immunocompromised Populations: TLRs in Innate Immunity and the Induction of Adaptive Immunity in the Neonate and Infant [2] University of Washington [3] NO1-AI-50023* [4] 
The overall goal of research proposed is to define comprehensively and in molecular and cellular detail differences in recognition and response to microbe-derived danger signals between adults, neonates and infants, and how these, in turn, contribute to differences in innate immunity and the induction of antigen-specific (adaptive) immunity. In so doing, we aim to discover candidate strategies by which immediate protection against potential bioterrorism agents might be provided to this vulnerable population, while at the same time facilitating the development of antigen-specific immunity to infection or immunization. The experience of our investigative team in host defense to infection, Toll-like receptor (TLR) biology and neonatal immunology, their history of cross-disciplinary collaborations, and their ongoing participation in the WWAMI (Washington, Wyoming, Alaska, Montana, Idaho) Regional Center for Excellence in Biodefense (RCE) provide a strong foundation for the proposed work.
ImmPort: Immunology Database and Analysis Portal
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