d6ff7fa4__Medicine___TheDrugCompany_com__Clinical_Comment
[Interacting Drug] Amiodarone [Effect] Amiodarone inhibited the metabolism of carvedilol in heart failure patients [Stereoselective effect of amiodarone on the pharmacokinetics of racemic carvedilol. Drug Metab Pharmacokinet 2005;20(6):423-7]. The S(−) enantiomer of carvedilol was affected to a greater extent than the R(+) enantiomer. [Clinical Comment] 
Monitor patients for signs of carvedilol excess if amiodarone is initiated in patients stabilized on carvedilol. Adjust the dose of carvedilol as needed.
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Clinical Comment