eaa777cd_CER_Inventory___CER_Inventory__Category
[Agency] NIH [Project Title] EFFECTIVENESS STUDIES WITH SECURELY POOLED HEALTHCARE DATA AND ADJUSTED ANALYSES [Institution] BRIGHAM AND WOMEN»S HOSPITAL [Amount] $479,903 [Summary] This proposal seeks to advance methods for pooling heterogeneous individuallevel electronic healthcare data in order to allow for pooled analyses with full multivariate adjustment with no sharing of private patient data.We will develop and test methods and algorithms for pooling both like and heterogeneous data elements, combining claims information from multiple health care providers and then augmenting these claims with electronic medical record and laboratory values. The methods will be neutral with respect to coding standards and will be robust to heterogeneous database structures. --- We will use the methods to perform three example studies, each of which requires pooled data due to infrequent exposure, small patient subgroups, rare outcomes, or a combination of these. We will explore, both statistically and operationally, when pooling of individual-level data will out-perform aggregate-level meta-analysis, and test the hypothesis that aggregate-level meta-analysis will yield substantially similar point estimates in most scenarios. --- We will publish and provide SAS code for all methods developed, and provide training sessions to relevant groups of researchers in order to broaden the scope and ensure lasting impact of the work performed. This 2-year project will significantly advance methodology for pooling individual-level information from diverse health care databases. [Completion/ Closing Date] 09/02/2010 [Link] link [Category] 
Research Methods
CER Inventory | CER Inventory
Category