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[0] Sullivan, Kathleen [1] Kinetic analysis of immunologic repletion and influenza vaccine responsiveness [2] Children´s Hospital of Philadelphia [3] NO1-AI-50024 [4] 
We propose a comprehensive analysis of the immunologic response to killed trivalent influenza vaccine in different immunocompromised populations in order to understand how to improve vaccine responses. This will provide insight into how to avoid vaccine failure. We hypothesize that there are specific immunologic mechanisms that are aberrant in cases of influenza vaccine failure in immunocompromised populations. By analyzing six populations with different immunologic deficits, we will identify functional predictors of vaccine failure/response. Detailed investigations of T cell precursor frequency, T cell cytokine production, T cell proliferation and B cell responses will be performed to identify the defects responsible for vaccine failure/response. The six populations are patients undergoing an autologous stem cell transplant for multiple myeloma, patients undergoing a tandem stem cell transplant for neuroblastoma, patients receiving chemotherapy, patients receiving a dendritic cell vaccine, patients receiving rituximab, and patients with chromosome 22q11.2 deletion syndrome.
ImmPort: Immunology Database and Analysis Portal
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