4f3d4ffe_inuum___BioPharm_International__Justification
[Process parameters] Dissolved oxygen [Initial risk assessment] High [Justification] 
Must be sufficient to maintain cell viability. Impacts yield by low cell growth. Controlled by rate of aeration. Scale to large scale by pre-defined model.
Determining Criticality-Process Parameters and Quality Attributes Part I: Criticality as a Continuum | BioPharm International
Justification