6dc5455c____The_Coppermind___17th_Shard__Entry
[Chapter] 51 [Entry] 
Once Ruin was free from his prison, he was able to influence people more strongly—but impaling someone with a Hemalurgic spike was difficult no matter what the circumstances. To achieve such things, he apparently began with people who already had a tenuous grip on reality. Their insanity made them more open to his touch, and he could use them to spike more stable people. Either way, it's impressive how many important people Ruin managed to spike. King Penrod, ruling Luthadel at the time, is a very good example of this.
The Hero of Ages/Epigraphs - The Coppermind - 17th Shard
Entry