253b068f_Grading_Guide___UpToDate__Clarity_of_risk_benefit
[Grade of Recommendation] 1C. Strong recommendation, low quality evidence Evidence from observational studies, unsystematic clinical experience, or from randomized, controlled trials with serious flaws. Any estimate of effect is uncertain. [Implications] Strong recommendation, and applies to most patients. Some of the evidence base supporting the recommendation is, however, of low quality. [Clarity of risk/benefit] 
Benefits appear to outweigh risk and burdens, or vice versa.
Grading Guide | UpToDate
Clarity of risk/benefit