82d16073___Great_Ormond_Street_Hospital__Etiology
[Event] CVC tip displacement through SVC [Can occur with] IVAP, tunneled CVC, PICC Intractable cough with infusion, pleural effusions, abnormal CXR/CT Substernal chest pain, dyspnea, fatigue [Etiology] 
Early: difficult insertion; Late: unknown; thrombosis of SVC or great veins may increase risk
Extravasation and infiltration | Great Ormond Street Hospital
Etiology