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[Agency] AHRQ [Project Title] MODERNIZING META-ANALYSIS TO FACILITATE COMPARATIVE EFFECTIVENESS REVIEWS [Institution] TUFTS MEDICAL CENTER [Amount] $402,750 [Summary] We propose to develop statistical methods and software for collectively analyzing multiple treatments across multiple endpoints and apply them to rank treatments based on multiple dimensions of health and well- being. 1) Develop new and enhance existing techniques for the statistical analysis of possibly incomplete multivariate meta-analytic data involving multiple (> 2) treatments, multiple outcomes or categories of outcomes and multiple follow-up times; 2) Implement these methods in an ongoing open-source software project so users will have access to customized and customizable algorithms and support for their use through analytic wizards that will guide users to appropriate statistical methods and presentation quality graphics and reports; and 3) Apply multivariate methods to a set of key clinical questions that we have identified as well as to topics in the EPC program as they arise over the course of this application so as to gain empirical insight into their strengths and weaknesses and to demonstrate their contribution to improving comparative effectiveness reviews. [Completion/ Closing Date] 08/02/2010 [Link] link [Category] 
Research Methods
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