253b068f_Grading_Guide___UpToDate__Clarity_of_risk_benefit
[Grade of Recommendation] 1B. Strong recommendation, moderate quality evidence Evidence from randomized, controlled trials with important limitations (inconsistent results, methodologic flaws, indirect or imprecise), or very strong evidence of some other research design. Further research (if performed) is likely to have an impact on our confidence in the estimate of benefit and risk and may change the estimate. [Implications] Strong recommendation and applies to most patients. Clinicians should follow a strong recommendation unless a clear and compelling rationale for an alternative approach is present. [Clarity of risk/benefit] 
Benefits clearly outweigh risk and burdens, or vice versa.
Grading Guide | UpToDate
Clarity of risk/benefit