253b068f_Grading_Guide___UpToDate__Clarity_of_risk_benefit
[Grade of Recommendation] 2C. Weak recommendation, low quality evidence Evidence from observational studies, unsystematic clinical experience, or from randomized, controlled trials with serious flaws. Any estimate of effect is uncertain. [Implications] Very weak recommendation; other alternatives may be equally reasonable. [Clarity of risk/benefit] 
Uncertainty in the estimates of benefits, risks, and burdens; benefits may be closely balanced with risks and burdens.
Grading Guide | UpToDate
Clarity of risk/benefit