ba36932d__Enterprise_Business_Community__Answer
[0] 10. [Question] In order to monitor the performance of a business transaction (example: Application web portal load, Login, run a query, log off). what pieces of software shall I consider? Agent or agentless? SiteScope and Operations manager are designed to monitor the infrastructure. SiteScope does provide URL monitoring and both SiteScope and Operations Manager can monitor your web services. [Answer] 
If you are looking for a true application management solution with real time user monitoring and synthetic transaction monitoring including the end user monitoring, we recommend HP Business Availability Center and the End User Management product suite.
Infrastructure Management Software Blog - HP Enterprise Business Community
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