69c49c27_ofessional_Configuration_Guide__Description
[Error] 0X800CCC0E [Service] SMTP [Description] 
This error means that you are able to connect to the server via POP, but your SMTP Service is either not running or is configured incorrectly. You can verify if the SMTP service is running by using the telnet utility to telnet to port 25 of your mail server. If the server responds, then the issue is most likely that your mail client settings are invalid.
MailEnable Professional Configuration Guide
Description