8fb70e90_Transfusion_Reaction__Pathophysiology
[Reaction] Acute haemolytic reaction [Symptom Description] This is a medical emergency. It results from rapid destruction (haemolysis) of the donor red blood cells by host antibodies. The symptoms are fever and chills, sometimes with back pain and pink or red urine (haemoglobinuria).Haemoglobin released by the destruction of red blood cells can cause acute renal failure. Uncontrolled bleeding DIC may occur [Pathophysiology] 
The majority of haemolytic reactions are caused by transfusion of ABO incompatible blood, eg group A, B or AB red cells to a group O patient. Most haemolytic reactions are the result of human error such as the transfusion of properly labelled blood to the wrong patient, or improper identification of pretransfusion blood samples.
Transfusion Reaction
Pathophysiology