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[Agency] NIH [Project Title] PREDICTING CARDIOVASCULAR RISK IN VULNERABLE PLAQUE RUPTURE [Institution] CITY COLLEGE OF NEW YORK [Amount] $408,078 [Summary] In Aim 1 we will use a high resolution micro-CT imaging system to examine a much broader sample of ruptured and non-ruptured human thin cap fibroatheroma and statistically analyze the frequency, size, shape and spatial distribution of the cellular-level microcalcifications. In Aim 2 we quantitatively evaluate the impact of the microcalcifications on the biomechanical stability of the cap using a three-dimensional (3D) multi-level finite element model (FEM) of realistic 3D geometries of human coronary lesions based on high resolution micro-CT imaging. [Completion/ Closing Date] 08/02/2010 [Link] link [Category] 
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