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[Agency] NIH [Project Title] THE CO-CLINICAL PROJECT: INFORMING CLINICAL TRIALS USING PRECLINICAL MOUSE MODELS [Institution] BETH ISRAEL DEACONESS MEDICAL CENTER [Amount] $2,064,367 [Summary] Succinctly put, what we propose with the "Co-Clinical Project" is that each clinical trial at the participating Institutions will be run "in parallel" with pre-clinical trials in appropriate, faithful and genetically relevant mouse models, and that the clinical, biological and pharmacological information (i.e. somatic mutational background, germline SNP variations, responsiveness to specific regimens; imaging, microarray and proteomics profiles) will be accrued, analyzed in parallel and integrated in order to facilitate the identification of patient subtypes, key genetic determinants, and biomarkers that predict response to specific treatments. [Completion/ Closing Date] 09/02/2010 [Link] link [Category] 
Medical treatments, items and services
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