46887615_2_Diabetes_Therapy_if_Approved__5
[0] TZDs (thiazolidinedione) [1] Pioglitazone (Actos) [2] Allow insulin to work better at the cellular level, and to a lesser degree reduce hapatic glucose production [3] Fairly effective, now pioglitazone is generic [4] Weight gain, concern about fluid retention and heart failure (Avandia removed from US market for this reason. [5] 
Losing favor due to potential for cardiovascular risks
Where Will Invokana (canagliflozin) Fit in Type 2 Diabetes Therapy if Approved
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