78d97f2a__Effective_Health_Care_Program_gth_of_evidence_rating_domains_Domain_Name
[Domain Type] Required Directness relates to: Whether evidence links interventions directly to a health outcome of specific importance for the review, and Whether the comparisons are based on head-to-head studies. The EPC should specify the comparison and outcome for which the SOE grade applies. Evidence may be indirect in several situations such as: The outcome being graded is considered intermediate (i.e., laboratory test results) in a review that is focused on clinical health outcomes (i.e., morbidity, mortality). Data do not come from head-to-head comparisons but rather from two or more bodies of evidence to compare interventions A and B – e.g., studies of A vs. placebo and B vs. placebo, or studies of A vs. C and B vs. C but not direct studies of A vs. B. Data are available only for proxy respondents (e.g., from family members or nurses) instead of directly from patients. Indirectness always implies that more than one body of evidence is required to link interventions to the most important health outcome. [Domain Score and Application] Score as one of two levels: Direct Indirect If the domain score is indirect, the EPC should specify what type of indirectness accounts for the rating. [Domain Name] 
Directness
Radiotherapy Treatments for Head and Neck Cancer: Update - Research Protocol | AHRQ Effective Health Care Program
Domain Name