8fb70e90_Transfusion_Reaction__Pathophysiology
[Reaction] Transfusion-associated acute lung injury (TRALI) [Symptom Description] TRALI is a syndrome of acute respiratory distress, often associated with fever, non-cardiogenic pulmonary oedema, and hypotension. Symptoms can develop within 2 to 8 hours after a transfusion ranging from mild to life-threatening. Most patients recover fully within 96 hours, and the mortality rate from this condition is less than 10%. [Pathophysiology] 
Pulmonary vascular effects are thought to occur secondary to cytokines in the transfused product or from interaction between patient white cell antigens and donor antibodies (or vice versa).
Transfusion Reaction
Pathophysiology