d6ff7fa4__Medicine___TheDrugCompany_com__Clinical_Comment
[Interacting Drug] Fluoxetine [Effect] Fluoxetine selectively inhibited CYP2D6-mediated metabolism and decreased the clearance of carvedilol in heart failure patients who were extensive metabolizers of CYP2D6 substrates [Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients. J Clin Pharmacol 2001;41(1):97-106]. The R(+) enantiomer was affected to a greater extent than the S(−) enantiomer. [Clinical Comment] 
Despite the significant effects of fluoxetine on carvedilol metabolism there was no significant difference in adverse events, blood pressure or heart rate over 4 weeks.
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Clinical Comment