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[0] Larsen, Christian [1] Protective Immunity in Transplant Recipients [2] Emory University [3] NO1-AI-50025* [4] 
Our projects seek to improve our understanding of the biological mechanisms that underlie the distinct immunosuppressive regimens in practice today (calcineurin-inhibitor, or CNI, and sirolimus based regimens) and in emerging regimens that employ agents with novel mechanisms of action, such as the CD28 costimulation blockers, and/or JAK3 kinase inhibitors. Such knowledge will be critical to strategies for enhancing desirable immune responses while not precipitating rejection. We are undertaking three complementary studies: Study 1: Characterization of the impact of CNI-based, sirolimus-based, and novel immunosuppressive regimens on protective immunity over time in renal transplant recipients, Study 2: A prospective comparison the magnitude and character of the immune response to influenza vaccine in defined transplant populations and healthy aged-matched volunteers, and Study 3: Responses to and control of vaccinia in immunosuppressed Rhesus Macaques.
ImmPort: Immunology Database and Analysis Portal
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