253b068f_Grading_Guide___UpToDate__Clarity_of_risk_benefit
[Grade of Recommendation] 2A. Weak recommendation, high quality evidence Consistent evidence from well performed randomized, controlled trials or overwhelming evidence of some other form. Further research is unlikely to change our confidence in the estimate of benefit and risk. [Implications] Weak recommendation, best action may differ depending on circumstances or patients or societal values. [Clarity of risk/benefit] 
Benefits closely balanced with risks and burdens.
Grading Guide | UpToDate
Clarity of risk/benefit