b8b20101_mor_lysis_syndrome_and_in_gout__sburicase__an_uricolytic_agent
It needs an adjustment of doses if patient has renal impairment, because its active metabolite, oxypurinol, is excreted in urine.
No adjustment of doses is necessary if patient has renal or hepatic impairment. In renal failure, allantoin may accumulate, but it is not toxic.
Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout
Rasburicase: an uricolytic agent