253b068f_Grading_Guide___UpToDate__Clarity_of_risk_benefit
[Grade of Recommendation] 2B. Weak recommendation, moderate quality evidence Evidence from randomized, controlled trials with important limitations (inconsistent results, methodologic flaws, indirect or imprecise), or very strong evidence of some other research design. Further research (if performed) is likely to have an impact on our confidence in the estimate of benefit and risk and may change the estimate. [Implications] Weak recommendation, alternative approaches likely to be better for some patients under some circumstances. [Clarity of risk/benefit] 
Benefits closely balanced with risks and burdens, some uncertainly in the estimates of benefits, risks and burdens.
Grading Guide | UpToDate
Clarity of risk/benefit