e10510d2__Information___Medicine_Online_odifications_for_Skin_Toxicity_Suggested_Dose_Modification
[Skin Toxicity Grade] Grade 3: Moist desquamation, ulceration, bulering or severe pain of the hands or feet, or severe discomfort that causes the patient to be unable to work or perform activities of daily living [Occurrence] 1st or 2nd occurrence [Suggested Dose Modification] 
Interrupt NEXAVAR treatment until toxicity resolves to Grade 0-1 When resuming treatment, decrease NEXAVAR dose by one dose level (400 mg daily or 400 mg every other day)
NEXAVAR(sorafenib)tablets 200 mg Drug Information - Medicine Online
Suggested Dose Modification