eaa777cd_CER_Inventory___CER_Inventory__Category
[Agency] NIH [Project Title] EPIDEMIOLOGY AND MECHANISMS OF ACCELERATED AGING IN HIV INFECTION [Institution] JOHNS HOPKINS UNIVERSITY [Amount] $498,606 [Summary] Using longitudinal data collected in the AIDS Linked to the IntraVenous Experience (ALIVE) study for up to 7 years, we will define trajectories and identify demographic, behavioral, and clinical correlates of physical function decline and a frailty-related phenotype. Utilizing our extensive biological repository and building on prior mechanistic work which identified selected inflammatory genes involved in frailty, we will evaluate circulating inflammatory markers and inflammatory gene expression levels in participants with or without physical function declines using a nested case-control study design. [Completion/ Closing Date] 09/02/2010 [Link] link [Category] 
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