253b068f_Grading_Guide___UpToDate__Clarity_of_risk_benefit
[Grade of Recommendation] 1A. Strong recommendation, high quality evidence Consistent evidence from well performed randomized, controlled trials or overwhelming evidence of some other form. Further research is unlikely to change our confidence in the estimate of benefit and risk. [Implications] Strong recommendations, can apply to most patients in most circumstances without reservation. Clinicians should follow a strong recommendation unless a clear and compelling rationale for an alternative approach is present. [Clarity of risk/benefit] 
Benefits clearly outweigh risk and burdens, or vice versa.
Grading Guide | UpToDate
Clarity of risk/benefit