appleton,_wisconsin | ispartof | little_chute,_wisconsin <sep> appleton (menominee: ahkōnemeh)  is a city in outagamie, calumet, and winnebago counties in the us state of wisconsin one of the fox cities, it is situated on the fox river, 30 miles (48 km) southwest of green bay and 100 miles (160 km) north of milwaukee appleton is the county seat of outagamie county as of the 2020 census it had a population of 75,644, making it the sixth largest city in wisconsin 
appleton. wisconsin is part of little chute. wisconsin.appleton is the county seat of outagamie county in wisconsin