st_louis | ispartof | greater_st_louis <tsp> alex_tyus | birthplace | st_louis <tsp> st_louis | ispartof | french_first_republic <tsp> st_louis | leadername | francis_g_slay <sep> st louis () is the second-largest city in missouri, united states it is located near the confluence of the mississippi and the missouri rivers in 2020, the city proper had a population of 301,578, while its bi-state metropolitan area, which extends into illinois, had an estimated population of over 28 million, making it the largest metropolitan area in missouri and the second-largest in illinois before european settlement, the area was a regional center of native american mississippian culture 
alex tyus was born in st. louis. part of greater st. louis. that city forms part of the french first republic and its leader is francis g. slay.st. louis is the second-largest city in missouri