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- 2003,,,, ,,, * I II III (R) TNF- (R) BAT1406 CHO , TNF - , TNF - , TNF - ,: ,: 40mg/0.8ml 20mg/0.4ml (R) IL-6R (R) (R)()(:TOFIDENCE) NMPA FDA EMA ,-6 (IL-6R), IL-6 (sIL-6R mIL-6R), sIL-6R mIL-6R(R)(:TOFIDENCE)NMPAFDA(RA)(sJIA)(CRS)(RA)( pJIA )(sJIA) BAT2606 IL-5 BAT2606 BAT2606 (: mepolizumab injection ,:,: Nucala ), G1 ( IgG1 ), IL-5 , IL-5 , IL-5 ,, CRSwNP EGPA HES ()() * BAT6026 * OX40 * BAT6026 BAT6026 OX40,OX40(CD4+CD8+TTreg)OX40LOX40,APCOX40OX40L,T,OX40L OX40 ,Th2T,BAT6026OX40/OX40L T ,ADCC OX40+T,BAT6026Th2 BAT4406F CD20 BAT4406F BAT4406F ADCC IgG1 BAT4406F B CD20 , NK , ADCC CDC B BAT2506 TNF- BAT2506 BAT2506TNF-,TNF-,TNF-TNFR,TNF-ADA, BAT2306 IL-17A BAT2306 ( BAT2306 ) , IgG1 kappa , 17A(IL - 17A) 17A/F(IL - 17A/F) , 17 BAT2206 IL-12/IL-23 BAT2206 BAT2206 IL-12IL-23p40, IL-12IL-23,BAT2206p40 ,, IL-12IL-23 BAT2406 IL-4R BAT2406 BAT2406 ()( IgG4 ), -4 ( IL-4 ) -13 ( IL-13 ) IL-4R IL-4 IL-13 I IL-4 , II IL-4 IL-13 (R) VEGF (R) (R) IgG1, (VEGF),(VEGF),VEGF,,,,(R) : ,BAT1308II/II