International -Level Rider s Rider s who are International -Level Rider s must  apply to the UCI for a TUE as soon as the need arise s.  Major Event Organization  A Major Event Organization  may require Rider s to apply to it for a TUE if they need to Use a Prohibited Substance  or a Prohibited Method  in connection with the Even t. Rider s shall refer to the applicable rules of UCI CYCLING REGULATIONS   Page 16 of 70 UCI ADR 2021  the Major Event Organization  for the requirements and procedure to follow in this situation.