If the National Anti-Doping Organization  does not refer the matter to WADA  for review, the TUE granted by IWF becomes valid for national-level Competition  as well when the twenty-one (21) day review deadline expires.16 / IWF 2021 ANTI-DOPING RULES›  IWF 2021 ANTI-DOPING RULES4.4.5  Retroactive TUE Applications If IWF chooses to collect a Sample  from an Athlete  who is not an International-Level Athlete  or a National-Level Athlete , and that Athlete  is Using  a Prohibited Substance  or Prohibited Method  for therapeutic reasons, IWF must permit that Athlete  to apply for a retroactive TUE.4.4.6  Expiration, Withdrawal or Reversal of a TUE4.4.6.1  A TUE granted pursuant to these Anti-Doping Rules: (a) shall expire automatically at the end of any term for which it was granted, without the need for any further notice or other formality; (b) will be withdrawn if the Athlete does not promptly comply with any requirements or conditions imposed by the TUEC upon grant of the TUE; (c) may be withdrawn by the TUEC if it is subsequently determined that the criteria for grant of a TUE are not in fact met; or (d) may be reversed on review by WADA or on appeal.