*C19*AD-4.2.3Substances of AbuseFor purposes of applying Article 10, Substances of Abuse shall include those Prohibited Substances which arespecifically identified as Substances of Abuse on the Prohibited List because they are frequently abused in societyoutside of the context of sport.AD-4.3WADA’s Determination of the Prohibited ListWADA’s determination of the Prohibited Substances and Prohibited Methods that will be included on the Prohibited List, theclassification of substances into categories on the Prohibited List, the classification of a substance as prohibited at all times orIn-Competition only, the classification of a substance or method as a Specified Substance, Specified Method or Substance ofAbuse is final and shall not be subject to any challenge by an Athlete or other Person including, but not limited to, anychallenge based on an argument that the substance or method was not a masking agent or did not have the potential toenhance performance, represent a health risk or violate the spirit of sport.AD-4.4Therapeutic Use Exemptions (“TUEs”)AD-4.4.1The presence of a Prohibited Substance or its Metabolites or Markers, and/or the Use or Attempted Use, Possessionor Administration or Attempted Administration of a Prohibited Substance or Prohibited Method, shall not beconsidered an anti-doping rule violation if it is consistent with the provisions of a TUE granted in accordance withthe International Standard for Therapeutic Use Exemptions.AD-4.4.2TUE ApplicationsAD-4.4.2.1 Athletes who are not International-Level Athletes shall apply to their National Anti-Doping Organizationfor a TUE.