A Sample will be invalid only when the Sample shows signs of extensive degradation, as determined by:  • 5αAND/A ≥ 0.1, and/or  • 5βAND/Etio ≥ 0.1  [Comment: In addition, following the reporting of the steroid profile in ADAMS by the Laboratory , the Sample may be evaluated as “invalid” by the APMU  upon review of the steroid profile data, for example, by considering the presence of substances that may alter the steroid profile in the Sample.]