ISA 2021 Anti -Doping Rules  Page 12 of 67     3.2.3   Departures from any other International Standard  or other anti -doping rule or policy set forth in the Code or these Anti -Doping Rules shall not invalidate analytical results or other evidence of an anti -doping rule violation, and shall not constitute a def ense to an anti -doping rule violation;15 provided, however, if the Athlete  or other Person establi shes that a departure from one of the specific International Standard  provisions listed below could reasonably have caused an anti-doping rule violation based on an Adverse Analytical Finding  or whereabouts failure, then ISA shall have the burden to establ ish that such departure did not cause the Adverse Analytical Finding or the w hereabouts failure:   (i)  a departure from the International Standard for Testing  and Investigations related to Sample collection or Sample handling which could reasonably have caused an anti -doping rule violation based on an Adverse Analytical Finding, in which case ISA  shall have the burden to establish that such departure did not cause the Adverse Analytical Finding;   (ii)  a departure from the International Standard for Results  Management  or International Standard for Testing and Investigations related to an Adverse Passport Finding  which could reasonably have caused an anti-doping rule violation, in which case ISA  shall have the burden to establish that such departure did not c ause the anti -doping rule violation;   (iii)  a departure from the International Standard for Results Management  related to the requirement to provide notice to the Athlete of the B Sample opening which could reasonably have caused an anti -doping rule viol ation based on an Adverse Analytical Finding , in which case ISA shall have the burden to establish that suc h departure did not cause the Adverse Analytical Finding ;16  (iv) a departure from the International Standard for Results Management  related to Athlet e notification which could reasonably have caused an anti-doping rule violation based on a whereabouts failure, in which case ISA shall have the burden to establish that such departure did not cause the w hereabouts failure.