Annex 1: Minimal requirements for the medical file to be used for the TUE process in the case of asthma and its clinical variants   The file must reflect current best medical practice to include:   (1) A complete medical history;  (2) A comprehensive report of the clinical examination with specific focus on the respiratory system;  (3) A report of spirometry with the measur e of the Forced Expiratory Volume in 1 second (FEV1);   (4) If airway obstruction is present, the spir ometry will be repeated after inhalation of a  short acting Beta-2 Agonist to demonstrate the reversibility of  bronchoconstriction;  (5) In the absence of reversible airway obstruction, a bronchial provocation test is required to establish the presen ce of airway hyper-responsiveness;   (6) Exact name, speciality, address (including telephone, e-mail, fax) of examining physician.