5.1 Adverse Analytical Findings 5.1.1 Initial Review Upon receipt of an Adverse Analytical Finding , the Results Management  Authority shall conduct a review to determ ine whether (a) an applicable TUE has been granted or will be granted as provided in the International Standard  for Therapeutic Use Exemptions  (Article 5.1.1.1), (b) there is any apparent departure from the  International Standard  for Testing  and Investigations or International Standard  for Laboratories that caused the Adverse Analytical Finding  (Article 5.1.1.2) and/or (c) it is apparent that the Adverse Analytical Finding  was caused by an ingestion of the relevant Prohibited Substance through a permitted route (Article 5.1.1.3).