4.4 Therapeutic Use Exemptions (“TUEs”)  4.4.1  The presence of a Prohibited Substance  or its Metabolites  or Markers , and/or the Use or Attempted Use , Possession  or Administrat ion or Attempted Administration  of a Prohibited  Substance  or Prohibited  Method  shall not be considered an anti -doping rule violation if it is consistent with the provisions of a TUE granted in accordance with the International Standard  for Therapeutic Use Exemptions.