ISTUE – January 20 23 Page 10 of 23     PART TWO:  STANDARDS AND PROCESS FOR GRANTING TUES   4.0 Obtaining a TUE  An Athlete who needs to Use a Prohibited Substance or Prohibited Method for Therapeutic  reasons must apply for and obtain a TUE prior to Using or Possessing the substance or method in question, unless the Athlete is entitled to apply for a TUE  retroactively under Article 4.1.