4.4 Therapeutic Use Exemptions   4.4.1  The presence of a Prohibited Substance or its Metabolites or Markers , and/or the Use or Attempted Use , Possession or Administration or Attempted Administration of a Prohibited Substance  or Prohibited Method shall not be considered an anti -doping rule  violation if it is consistent with the provisions of a TUE granted in  accordance with the International Standard for Therapeutic Use  Exemptions.