[Comment to Article 2.2: It has alwaysbeen the case that Use or AttemptedUse of a Prohibited Substance orProhibited Method may beestablished by any reliable means.As noted in the Comment to Article3.2 (Methods of Establishing Factsand Presumptions), unlike the proofrequired to establish an anti-dopingrule violation under Article 2.1,Use or Attempted Use may also beestablished by other reliable meanssuch as admissions by the Athlete,witness statements, documentaryevidence, conclusions drawn fromlongitudinal profiling, or otheranalytical information whichdoes not otherwise satisfy all therequirements to establish “Presence”of a Prohibited Substance underArticle 2.1.