Tests conducted to determine integrity under freezing conditions shall use the matrix or material that will be stored in the Sample  bottles, containers or tubes i.e., urine, blood, or capillary blood applied on a dried blood spot absorbent Sample  support  (e.g., dried blood spot  cellulose card or other equipment made of another material) ; (iii) Are constructed of a material and sealing system that can withstand a minimum of three (3) freeze/thaw cycles;  g) The A and B bottles, containers and tubes shall be transpar ent so the Sample is visible;  h) Have  a sealing system  which  allows  verification  by the Athlete  and the DCO  that the Sample  is correctly sealed in the A and B bottles or  containers;  i) Have a built -in security identification feature(s) which allows verification of the authenticity of the  equipment;  j) Are compliant  with the standards  published by the International  Air Transport Association (IATA) for the transport of exempt human specimens which includes urine and/or blood Samples  in order to prevent leakage during transportation by  air or are compliant  with the local and international regulations for the transport of dried blood spot Samples , if applicable;    ISTI – Effective 1 January 2023  Page 48 of 92 k) Comply with local regulatory requirements for medical devices (for blood and dried blood spot  Samples ) where necessary, as well as any other applicable law or regulation;   l) Have been manufactured under the internationally recognized ISO 9001 certified standard  which includes quality control management systems;  m) Can be resealed after initial opening by a Laboratory  using a new unique Tamper - Evident  sealing system with a unique numbering system to maintain the integrity of the Sample and Chain of Custody  in accordance with the requirements of the International Standard for Laboratories  for long term storage of the Sample and Further  Analysis ; n) Have  undergone  testing  by a testing institution  that is independent of the manufacturer and is ISO 17025 accredited, to validate at a minimum that the equipment meets the criteria set out in subsections b), f), g), h), i), j) and m) above;  o) Any modification to the material or sealing system of the equipment shal l require re-testing to ensure it continues to meet  the stated  requirements as per n ) above;  For Urine Sample Collection : p) Have  the capacity  to contain a minimum  of 85 mL volume of urine in each A and B bottle or  container;  q) Have a visual marking on the A and B bottles or containers and the collection vessel, indicating:  (i) the minimum volume of urine required in each A and B bottle or container as outlined in Annex C -  Collection of Urine  Samples ;  (ii) the maximum volume levels that allow for expansion when frozen without compromising the bottle, container or the sealing system;  and (iii) the level of Suitable Volume of Urine for Analysis  on the collection vessel.