4.4.5  Retroactive TUE applications4.4.5.1  Subject to Article 4.4.5.2, an Athlete may apply for a retroactive TUE on the grounds set out in Articles 4.1 and 4.3 of the International Standard for Therapeutic Use Exemptions.4.4.5.2  If the BIU chooses to test an Athlete who is not an International-Level Athlete or a National-Level Athlete, the BIU will permit that Athlete to apply for a retroactive TUE for any Prohibited Substance or Prohibited Method that the Athlete is Using for therapeutic reasons.4.4.6  Expiration, cancellation, withdrawal or reversal of a TUE4.4.6.1  A TUE granted pursuant to these IBU Anti-Doping Rules: (a)   will expire automatically at the end of any period for which it was granted, without the need for any further notice or other formality; (b)   will be cancelled if the Athlete does not promptly comply with any requirements or conditions im-posed by the TUE Committee upon grant of the TUE; (c)   may be withdrawn by the TUE Committee if it is subsequently determined that the criteria for grant of a TUE are not in fact met; or(d)   may be reversed on review by WADA or on appeal.