World Karate Federation (WKF) Anti -Doping Rules – in effect as of 1st January 2021  Page 11 of 66    anti-doping rule violation based on an Adverse Analytical Finding  or whereabouts failure, then the WKF  shall have the burden to establish that such departure did not cause the Adverse Analytical Finding or the whereabouts failure:   (i)  a departure from the International Standard  for Testing  and Investigations related to Sample  collection or Sample  handling  which could reasonably have caused an anti -doping rule violation based on an Adverse Analytical Finding , in which case the WKF  shall have the burden to establish that such departure did not cause the Adverse Analytical Finding ;  (ii)  a departure from the International Standard  for Results Management  or International Standard  for Testing  and Investigations related to an Adverse Pa ssport Finding  which could reasonably have caused an anti-doping rule violation, in which case the WKF  shall have the burden to establish that such departure did not cause the anti -doping rule violation;   (iii)  a departure from the International Standard  for Results Management  related to the requirement to provide notice to the Athlete  of the B Sample  opening which could reasonably have caused an anti -doping rule violation based on an Adverse Analytical Finding , in which case The WKF  shall have the burden to establish that such departure did not cause the Adverse Analytical Finding ;16  (iv) a departure from the International Standard  for Results Management  related to Athlete  notification which could reasonably have caused an anti-dopin g rule violation based on a whereabouts failure, in which case the WKF  shall have the burden to establish that such departure did not cause the whereabouts failure.