4.4  Therapeutic Use Exemptions (“TUEs ”)   4.4.1   The presence of a Prohibited Substance  or its Metabolites  or Markers , and/or the Use or Attempted Use , Possession  or Administration  or Attempted Administration  of a Prohibited Substance  or Prohibited Method , shall not be considered an anti -doping rule viola tion if it is consistent with the provisions of a TUE granted in accordance with the International Standard  for Therapeutic Use Exemptions .