]4.2.3  Substances of AbuseFor purposes of the application of Article 10, certain Prohibited Substances are specifically classified on the Prohibited List as ‘Substances of Abuse’ because they are frequently abused in society outside of the context of sport.4.3  WADA’s determination of the Prohibited List WADA’s determination of the Prohibited Substances and Prohibited Methods that are (or will be) included on the Prohibited List, the classification of substances into categories on the Prohibited List, the classifica-tion of a substance as prohibited at all times or In-Competition only, and the classification of a substance or method as a Specified Substance, Specified Method or Substance of Abuse, is final and not be subject to any challenge by an Athlete or other Person, including (without limitation) any challenge based on an argument that the substance or method is not a masking agent or does not have the potential to enhance performance, represent a health risk, or violate the spirit of sport.4.4 TUEs:4.4.1  The presence of a Prohibited Substance or its Metabolites or Markers (Article 2.1), and/or Use or Attempted Use of a Prohibited Substance or a Prohibited Method (Article 2.2), Possession of a Prohibited Substance or a Prohibited Method (Article 2.6), or Administration or Attempted Administration of a Pro-hibited Substance or Prohibited Method (Article 2.8), will not be considered an anti-doping rule violation if it is consistent with the provisions of a TUE granted in accordance with the International Standard for Therapeutic Use Exemptions.4.4.2  TUE applications4.4.2.1  Athletes who are not International-Level Athletes must apply to their National Anti-Doping Organ-isation for a TUE.