If the National Anti-Doping Organization does not refer the matter to WADA  for review, the TUE granted by the International Federation becomes valid for national-level Competition as well when the twenty-one (21) day review deadline expires.4.4.4 A Major Event Organization may require Athletes to apply to it for a TUE if they wish to Use a World Anti-Doping Code 20211   PARTDoping Control38Prohibited Substance or a Prohibited Method in connection with the Event.