39 4.5.2  Removal of Samples  for Laboratory Quality Assessment  ............................  40 4.6 WADA  Monitoring of Accreditation Status  ................................ ................................  40 4.6.1  Maintenance of WADA Accreditation  ................................ .........................  40 4.6.2  Re-accreditation Costs  ................................ ................................ ..............  40 4.6.3  Issuing and Publication of Accreditation Certificate  ................................ ..... 40 4.6.4  Withdrawal of WADA Accreditation  ................................ ............................  41 4.6.5  Consequences of Suspended or Revoked Accreditation or Analytical Testing Restriction  ................................ ................................ ................................  50 4.6.6  Reinstatement of Suspended Accreditation or Lifting of the Analytical Testing  Restriction  ................................ ................................ ................................  56 4.6.7  Voluntary Cessation of Laboratory Operations  ................................ ...........  59 4.7 Process and Requirements for WADA  Laboratory Approval for the ABP....................  60 4.7.1  Applicant Laboratory for WADA  Approval for the ABP ................................  60 4.7.2  Candidate Laboratory for WADA  Approval for the ABP ...............................  61 4.7.3  Granting of WADA  Approval for the ABP................................ ....................  63 4.7.4  Maintaining Status as an ABP Laboratory  ................................ ..................  64 5.0 Application of ISO/IEC 17025 to the Analysis of Samples  ................................ .........  66 5.1 Introduction and Scope  ................................ ................................ ...........................  66 5.2 Structural and Resource Requirements  ................................ ................................ .... 66 5.2.1  General  ................................ ................................ ................................ .... 66    ISL – January 2021                            5.2.2  Laboratory Personnel  ................................ ................................ ................  66 5.2.3  Laboratory Facilities and Environmental Conditions ................................ .... 69 5.2.4  Laboratory Equipment  ................................ ................................ ...............  73 5.2.5  Metrological Traceability ................................ ................................ ............  73 5.2.6 Subcontracting of Analysis  ................................ ................................ ........  74 5.2.7  Purchasing of Services and Supplies  ................................ .........................  75 5.3 Process Requirements  ................................ ................................ ............................  75 5.3.1  Reviewing of Requests, Tenders and Contracts  ................................ .........  75 5.3.2  Reception, Registration and Handling of Samples  ................................ ...... 75 5.3.3  Acceptance of Samples  for Analysis  ................................ ..........................  76 5.3.4  Initial Storage and Sample  Aliquoting for Analysis  ................................ ...... 79 5.3.5  Selection and Validation of Analytical Testing  Procedures  ..........................  80 5.3.6  Sample  Analysis  ................................ ................................ .......................  85 5.3.7  Assuring the Validity of Analytical Results  ................................ ................  101 5.3.8  Results Management  ................................ ................................ ..............  103 5.3.9  Control of Nonconformities in Analytical Testing  ................................ ....... 109 5.3.10  Complaints  ................................ ................................ .............................  109 5.3.11  Storage of Samples  ................................ ................................ ...............  110 5.3.12  Secondary Use  or Disposal of Samples  and Aliquots  ...............................  115 5.4 Management Requirements  ................................ ................................ ..................  117 5.4.1  Organization  ................................ ................................ ...........................  117 5.4.2  Management Reviews ................................ ................................ .............  117 5.4.3  Document Control  ................................ ................................ ...................  117 5.4.4  Control and Storage of Technical Records  ................................ ...............  117 5.4.5  Cooperation with Customers and with WADA ................................ ...........  117 6.0 WADA  External Quality Assessment Scheme (EQAS)  ................................ ............  120 6.1 Types of EQAS  ................................ ................................ ................................ ..... 120 6.1.1  Blind EQAS  ................................ ................................ ............................  120 6.1.2  Double -Blind EQAS  ................................ ................................ ................  120 6.1.3  Educational EQAS  ................................ ................................ ..................  120 6.2 EQAS Sample Number and Composition  ................................ ...............................  120 6.2.1  Number of EQAS Samples  ................................ ................................ ...... 120 6.2.2  Composition of EQAS Samples  ................................ ...............................  121 6.2.3  Laboratory Analytical Testing  Procedures Used in EQAS  .........................  123    ISL – January 2021                            6.3 Reporting of EQAS results ................................ ................................ .....................  123 6.3.1  Reporting Blind EQAS Results  ................................ ................................  124 6.3.2  Reporting Double -Blind EQAS Results  ................................ ....................  124 6.3.3  Reporting Educational EQAS Results  ................................ ......................  125 6.3.4  Reporting Results for EQAS Samples Containing Non -Threshold Substances ................................ ................................ ................................ ..............  125 6.3.5  Reporting Results for EQAS Samples Containing Threshold Substances  .. 125  7.0 Evaluation of Laboratory EQAS and Routine Analytical Testing  Performance  ....... 127 7.1 Evaluation of EQAS Results  ................................ ................................ ..................  127 7.1.1 EQAS Samples Containing Non -Threshold Substances  ...........................  128 7.1.2  EQAS Samples Containing Threshold Substances  ................................ ... 128 7.2 Evaluation of Laboratory Performance  ................................ ................................ ... 130 7.2.1  False Adverse Analytical Finding  ................................ .............................  130 7.2.2  False Negative Finding  ................................ ................................ ...........  137 7.2.3  Further Procedural Evaluations  ................................ ..............................  138 7.3 Overall Laboratory Evaluation  ................................ ................................ ................  138 Points Scale Table for Assessment of Laboratory and Probationary Laboratory Performance  ................................ ................................ ...........................  140 7.4 Probationary Period and Probationary Laboratory Evaluation ................................ .. 142 7.4.1  Analytical Testing  Procedures Utilized by Probationary Laboratories for the Analysis of EQAS samples  ................................ ................................ ...... 142 7.4.2  False Adverse Analytical Finding  Result  ................................ ..................  142 7.4.3  False Negative Finding  ................................ ................................ ...........  142 7.4.4  Threshold Substance Result  ................................ ................................ ... 143 7.4.5  Overall Probationary Laboratory Evaluation  ................................ .............  143 PART THREE: ISL ANNEXES  ................................ ................................ ...........................  145 ISL ANNEX A - CODE OF ETHICS FOR LABORATORIES and ABP LABORATORIES  ..... 145 1.0 Confidentiality  ................................ ................................ ................................ ....... 145 2.0 Research in Support of Doping Control  ................................ ................................ .. 145 2.1 Research on Human Subjects  ................................ ................................ .