ISTUE – January 20 23 Page 12 of 23     4.3 In exceptional circumstances and notwithstanding any other provision in this International Standard for Therapeutic  Use Exemptions , an Athlete may apply for and be granted retroactive approval for their Therapeutic  Use of a Prohibited Substance or Prohibited Method if, considering the purpose of the Code, it would be manifestly unfair not to grant a retroactive TUE.