8.1.2  When assessing a Passport  that generated an ATPF : • All ATPFs shall be reviewed by a Laboratory -based APMU  manager;  [Comment : ATPFs are generated by the following primary Markers: hemoglobin (HGB) and the OFF-Score for the Hematological Module; the testosterone to epitestosterone ratio (T/E) in urine, and testosterone (T) and/or the testosterone to androstenedione ra tio (T/A4) in blood for the Steroidal Module; and the GH -2000 score for the Endocrine Module.]