4.4 Therapeutic Use Exemptions  (“TUEs ”)  4.4.1  The presence of a Prohibited Substance or its Metabolites or Markers , and/or the Use or Attempt ed Use , Possession or Administration or Attempted Administration of a Prohibited Substance or Prohibited Method , shall not be considered  an anti-doping  rule violation  if it is consistent  with the provisions  of a TUE granted in accordance with the Internati onal Standard for Therapeutic Use Exemptions .