of the panel, lining up the four corners with the pin marks that you made. turn the panel with attached paper over and use a center punch or nail to punch the center of each "x" or hole location. this is necessary to both the mark the drilling location and to start the hole and keep the drill bit from wandering.
start with a drill for the smallest hole required (or 1/8" if no smaller holes are needed). drill all of the holes to that size, even the larger ones. select a drill for the next largest size that is needed, and drill out all of the holes for that you 