there will be no interaction with them while playing.
there is a huge difference between cards not in play and cards removed from the game: cards not in play are still a part of the game and might come into play at some point. cards in hand or in the deck or even in the grave are examples of cards not in play. in contrast, cards that have been removed from the game may never in any way become part of the current game.
only unmarked creatures may attack or defend.
the active player is the only one that may perform attacks, and only during his/her attack phase.
when attacking, the player must use 