Researchers from the University of Washington have used CRISPR gene-editing technology to examine the significance of variants of the BRCA1 gene in causing cancer in humans. The study examined More than 1 million different mutations of the BRCA1 gene to discover which were harmless and allowed the human cells to survive and which were dangerous, resulting in the death of the cell. The researchers, Jay Shendure, Greg Findlay and Lea Starita, said the behaviour of the variants in the cells would enable better prediction of the cancer risk of the BRCA1 gene in humans.
Researchers from the University of Washington have used CRISPR gene-editing technology to examine the significance of variants of the BRCA1 gene in causing cancer in humans. The study examined 4,000 different mutations of the BRCA1 gene to discover which were harmless and allowed the human cells to survive and which were dangerous, resulting in the death of the cell. The researchers, Jay Shendure, Greg Findlay and Lea Starita, said the behaviour of the variants in the cells would enable better prediction of the cancer risk of the BRCA1 gene in humans.