Floyd Mayweather 's superfight against Manny Pacquiao on May 2 is to be conducted under the US Anti-Doping Agency ( USADA ) testing program . The welterweight rivals have agreed that their Las Vegas showdown will observe the rules established under the World Anti-Doping Code ( Code ) , the World Anti-Doping Agency ( WADA ) Prohibited List and the USADA Protocol for Olympic and Paralympic Movement Testing . Both fighters have agreed to unannounced blood and urine testing without reservation and will be tested out of competition prior to the fight and in competition after the fight . Floyd Mayweather Jnr posted pictures to his social media ahead of mega-fight with Manny Pacquiao on May 2 . Some of the banned substances that will be tested for at the WADA-accredited laboratory are growth hormone ( HGH ) , erythropoietin ( EPO ) and the use of carbon isotope ratio ( CIR ) . 'It 's a strong statement of the importance of clean and safe competition to have these two fighters voluntarily agree to have a WADA level anti-doping program implemented for this fight , ' said USADA chief executive Travis Tygart . 'We commend them for their stance on clean sport and the message it sends to all those who want to compete clean at the highest levels of all sport . ' Mayweather vs Pacquiao is widely considered to be one of the biggest boxing fights of all-time . Mayweather and Pacquiao are set to earn hundreds of millions from the blockbuster fight . Plans for the pair to clash five years ago when at the peak of their powers were abandoned after Pacquiao refused to participate in blood testing at Mayweather 's insistence . The two went head to head for the first and only time prior to their collision at the MGM Grand at a press conference in Los Angeles on Wednesday . No publicity tour has been scheduled and they will not meet again until fight week . The showdown is set to be the richest in boxing history , with an estimated shared purse of 250,000,000 US dollars ( £167.4million ) . Mayweather , 38 , is coming to the end of a brilliant , and as yet unbeaten , professional boxing career .
Floyd Mayweather 's comes up against Manny Pacquiao on May 2 . Rivals have agreed USADA bout will observe the Las Vegas program . Both have agreed to unannounced blood and urine testing . Tests will happen prior to the fight and in competition after the fight .