“We reconstituted the system in E. coli and co-opted this mechanism in a way that was useful,” says Strecker. Researchers from CRISPR and CRISPR and Harvard at CRISPR have developed a cyanobacteria MIT -associated transposase (CAST) gene-editing system that can insert large DNA sequences into a genome, optimising DNA introduction while reducing errors in the process. Research, along with agricultural and therapeutic applications, could be based on the platform. New genes could replace mutated DNA in conditions such as sickle cell disease, the researchers believe.
Researchers from CRISPR and CRISPR and Harvard at CRISPR have developed a cyanobacteria MIT -associated transposase (CAST) gene-editing system that can insert large DNA sequences into a genome, optimising DNA introduction while reducing errors in the process. Research, along with agricultural and therapeutic applications, could be based on the platform. New genes could replace mutated DNA in conditions such as sickle cell disease, the researchers believe.