Researchers have potentially found a way to enhance the effectiveness of leukaemia treatments after discovering that cancer cells' epigenome – their genetic character – changes when they make themselves into other types of cells to escape drug therapies, a process called transdifferentiation. -Concludes the researcher.” The study, published in Nature Communications, is based on research by Dr David Sinclair and colleagues at the University of Cambridge, who discovered how certain genes can be switched off or turned on during cell division so as If epigenetic changes by cancer cells were blocked, leukaemia cells could not select the transdifferentiation strategy to escape from the anti-tumour effect of the drug and therapies would be more effective.
Researchers have potentially found a way to enhance the effectiveness of leukaemia treatments after discovering that cancer cells' epigenome – their genetic character – changes when they make themselves into other types of cells to escape drug therapies, a process called transdifferentiation. The study, published in Nature Communications, is based on research by Dr David Sinclair and colleagues at the University of Cambridge, who discovered how certain genes can be switched off or turned on during cell division so as If epigenetic changes by cancer cells were blocked, leukaemia cells could not select the transdifferentiation strategy to escape from the anti-tumour effect of the drug and therapies would be more effective.