Researchers at the Department of Cellular have harnessed chemically modified RNA -based drugs, the intermediary between DNA and proteins, to perform CRISPR/Cas9 gene editing with more potency and efficiency. (grants R01-GM 074150, R01-NS27036 and F32-GM109657). The researchers have improved the the University of California, San Diego School of Medicine and Isis Pharmaceuticals component, CRISPR by synthesising a RNA molecule to perform its role in seeking out the specific location where the Cas9 enzyme can execute the editing. Commenting on the study, senior author C. Frank Bennet , PhD Chair of CRISPR/Cas9 and Molecular Medicine at UC UC described the "many advantages over the current CRISPR/Cas9 system, such as increased editing efficiency and potential selectivity" his team had acheived and underlined that the improved CRISPRs could be produced "efficiently, on an industrial scale and in a commercially feasible manner today ."
Researchers at the Department of Cellular have harnessed chemically modified RNA -based drugs, the intermediary between DNA and proteins, to perform CRISPR/Cas9 gene editing with more potency and efficiency. The researchers have improved the the University of California, San Diego School of Medicine and Isis Pharmaceuticals component, CRISPR by synthesising a RNA molecule to perform its role in seeking out the specific location where the Cas9 enzyme can execute the editing. Commenting on the study, senior author C. Frank Bennet , PhD Chair of CRISPR/Cas9 and Molecular Medicine at UC UC described the "many advantages over the current CRISPR/Cas9 system, such as increased editing efficiency and potential selectivity" his team had acheived and underlined that the improved CRISPRs could be produced "efficiently, on an industrial scale and in a commercially feasible manner today ."