Researchers at the University of California , San Diego School of Medicine and Isis Pharmaceuticals have harnessed chemically modified RNA - based drugs , the interaction between DNA and proteins , to perform CRISPR / Cas9 gene editing with more potency and efficiency . The researchers have improved the RNA gene , CRISPR by synthesising a RNA molecule to perform its role in seeking out the specific site where the editing enzyme will execute the editing . "Leveraging Isis' expertise in developing RNA-targeted compounds, together the team has demonstrated that we can develop molecules that enhance the effectiveness of the CRISPR mechanism." Commenting on the study , senior author Don Cleveland , PhD Chair of the Department of Cellular and Molecular Medicine at UC San Diego described the " many advantages over the current CRISPR / Cas9 technology , such as increased editing efficiency and potential selectivity " his team had acheived and underlined that the improved CRISPRs could be used " efficiently , on an industrial scale and in a commercially feasible manner today . "
Researchers at the University of California , San Diego School of Medicine and Isis Pharmaceuticals have harnessed chemically modified RNA - based drugs , the interaction between DNA and proteins , to perform CRISPR / Cas9 gene editing with more potency and efficiency . The researchers have improved the RNA gene , CRISPR by synthesising a RNA molecule to perform its role in seeking out the specific site where the editing enzyme will execute the editing . Commenting on the study , senior author Don Cleveland , PhD Chair of the Department of Cellular and Molecular Medicine at UC San Diego described the " many advantages over the current CRISPR / Cas9 technology , such as increased editing efficiency and potential selectivity " his team had acheived and underlined that the improved CRISPRs could be used " efficiently , on an industrial scale and in a commercially feasible manner today . "