Researchers at the University of California , San Diego School of Medicine and Isis Pharmaceuticals have harnessed chemically modified RNA - based drugs , the interaction between DNA and proteins , to perform CRISPR / Cas9 gene editing with more potency and efficiency . The researchers have improved the RNA gene , CRISPR by synthesising a RNA molecule to perform its role in seeking out the specific site where the editing enzyme will execute the editing . Commenting on the study , senior author Don Cleveland , PhD Chair of the Department of Cellular and Molecular Medicine at UC San Diego described the " many advantages over the current CRISPR / Cas9 technology , such as increased editing efficiency and potential selectivity " his team had acheived and underlined that the improved CRISPRs could be used " efficiently , on an industrial scale and in a commercially feasible manner today . "
Researchers at the University of California, San Diego School of Medicine and Isis Pharmaceuticals have harnessed chemically modified RNA-based drugs, the intermediary between DNA and proteins, to perform CRISPR/Cas9 gene editing with more potency and efficiency. The researchers have improved the RNA component, CRISPR by synthesising a RNA molecule to perform its role in seeking out the specific location where the Cas9 enzyme can execute the editing. Commenting on the study, senior author Don Cleveland, PhD Chair of the Department of Cellular and Molecular Medicine at UC San Diego described the "many advantages over the current CRISPR/Cas9 system, such as increased editing efficiency and potential selectivity" his team had acheived and underlined that the improved CRISPRs could be produced "efficiently, on an industrial scale and in a commercially feasible manner today."