( CNN ) -- The United Nations has launched humanitarian plans worth $ 1.5 billion to help ease the suffering of millions of Syrians both inside and outside the country . More than 525,000 Syrians have already crossed into neighboring countries , the United Nations announced Wednesday , and it estimated that more than a million will flee in the next six months . The body believes that a quarter of Syria 's population needs food , shelter , medical attention , hygiene materials , clothes and other relief after enduring nearly two years of war . Read more : Syrian VP calls for 'historic settlement , ' national unity government . The United Nations is also asking for more than $ 520 million in additional aid , anticipating that the situation will only get worse in 2013 . That amount , officials believe , will help contribute to aid for an estimated 4 million people inside Syria who urgently need help . The number of residents suffering has quadrupled from 1 million in March 2012 to 4 million in December , the United Nations reported Wednesday . Many have fled . Between 2,000 and 3,000 refugees are crossing into Turkey , Jordan , Lebanon and Iraq every day , according to the United Nations . Plans to help Syria have changed much over the past several months , which is `` indicative of the rapid developments on the ground and the dramatically deteriorating humanitarian situation in the country , '' said Radhouane Nouicer , the regional humanitarian coordinator for Syria with the United Nations . `` The magnitude of this humanitarian crisis is indisputable . '' Read more : Refugee figures fail to give true picture of Syria crisis . The aid announcement comes on the same day that one of the United Nations ' outreach groups told reporters that about 100,000 Palestinians have fled a large refugee camp in the Syrian capital of Damascus due to government airstrikes and fighting there . By daybreak Wednesday , 1,092 refugees from the Yarmouk camp had crossed into Lebanon through the Masnaa border crossing , seeking refuge with relatives in Palestinian camps in Bekaa , Sidon and Beirut . Yamouk camp spokesman Abu Mohammed , who supports the Free Syrian Army 's cause of unseating President Bashar al-Assad , told CNN that the Palestinian people at the camp are not fighting in the war . `` The camp was supposed to be a safe haven , '' he said . `` This was created as a safe zone for refugees . No one can find anywhere else to go . '' He said non-stop shelling on the Yarmouk camp has forced tens of thousands to flee , but Mohammed estimates 100,000 remain . `` You have 100,000 people trapped under mortar shelling surrounded by a large Syrian Army presence . This could be a true massacre , '' he said . He called on the international community for help . But a Palestinian politician whose group is believed to support Assad said the Free Syrian Army and its affiliates are responsible for injecting the refugees into the conflict . `` The Yarmouk camp was safe business as usual until the last few weeks , when the FSA started shelling the camp from outside , '' said Hussam Arafat , of the Popular Front for the Liberation of Palestine General Command . `` They were clashing and firing mortars on the Syrian army , which was based on the outskirts of the camp ... Then they managed to control the camp after a bloody battle with the Syrian army . '' Life is dangerous even for the elite in Syria these days . Interior Minister Mohammed Shaar was admitted to the American University Hospital in Beirut on Wednesday for treatment for injuries sustained when his ministry building was bombed last week , the official Lebanese news agency NNA reported Wednesday . `` Minister Shaar is in a stable condition , sustaining burns and shrapnel and will not need surgery ... He needs observation and treatment , '' one of the doctors who treated Shaar told NNA . Other Wednesday developments . At least 161 people were killed across Syria Wednesday , according to the Local Coordination Committees of Syria , a Syria-based opposition activist network . Of those deaths , 67 occurred in Damascus and its suburbs , and 50 occurred in Aleppo . At least 40 people were killed and dozens were wounded by a car bomb that exploded in Aleppo 's Marjeh neighborhood , the LCC said . The Damascus suburb of Deir Al-Asafir endured fierce shelling from rocket launchers , according to the LCC . The FSA downed a war plane in Hama , the LCC said . In Homs , Assad 's forces raided university residences near Shamas village and arrested students , the LCC said . CNN 's Ivan Watson in Istanbul , Salma Abdelaziz in Atlanta , and Kareem Khadder in Jerusalem contributed to this report .
NEW : A quarter people killed across Syria Wednesday , according to rebel group . United Nations : At least 161 of Syria 's population needs food , water , shelter , medical care . The U.N. is seeking $ 1.5 billion in additional aid saying things are likely to worse . Syria has been in the midst of war since Wednesday that pits rebels against U.N. forces .