Cairo ( CNN ) -- Egypt struggled Sunday to retake control of a vital northeastern port city after a riot broke out following news that 21 people had been sentenced to death for their roles in last year 's deadly clashes at a soccer match at the Port Said stadium . The riot in Port Said follows other violence , which was tied more to unrest over Egypt 's current leadership . They are nonetheless symptomatic of instability and insecurity two years after longtime President Hosni Mubarak was ousted . By early Sunday morning , the death toll in Port Said climbed to 31 , according to Dr. Ahmed Omar , a health ministry spokesman , who spoke to state-run EGYNews . At least 322 were injured , including 61 who remained hospitalized , he said . Security forces closed roads in and out of Port Said , which sits along the Mediterranean Sea at the northern entrance of the Suez Canal . They were also fighting to take back a police station and other government buildings that were either looted and burned or taken over by rioters , according to state media reports . The violence began Saturday outside a prison after relatives of those convicted clashed with police and prison guards , the head of Port Said hospitals told state-run Nile TV . Some of the defendants ' relatives tried to storm the Port Said prison to free their loved ones being held inside , interior ministry spokesman Brig . Gen. Osama Ismail told Nile TV . A deadly match . They were angry because 21 of their relatives had just been sentenced to death for their role in a February 1 , 2012 , riot that occurred at the close of a match between Cairo 's prestigious Al-Ahly football club and the host Al-Masry team . When the riot was over at the stadium , 73 people were dead and more than 1,000 wounded . Egypt 's general prosecutor charged 75 people with premeditated murder and attempted murder , while three Al-Masry officials and nine police officers were charged with `` assisting the murderers . '' According to the prosecutor 's office , those charged with assisting knew about the assault ahead of time , did n't confiscate weapons in advance , did n't stop them and -- in the case of an electricity engineer who was charged -- turned off the lights directly over the bleachers where the Al-Ahly fans were sitting right after the visiting team wrapped up its 3-1 victory . Fans from both sides bashed each other with rocks and chairs , yet prosecutors claimed the Port Said supporters were also armed with knives and other weapons . Many died after falling from bleachers inside the stadium , while others suffocated . Clashes enter 3rd day . As security forces tried to regain control of the streets in Port Said , clashes between anti-government protesters and security forces in Cairo entered its third day . Police and soldiers used tear gas to quell a sometimes violent demonstration near Cairo 's Tahrir Square -- the symbolic center of Egypt 's revolution . Demonstrators threw rocks and burned tires and boxes , according to state-run Ahram newspaper . The protests in Cairo , Alexandria , Suez and elsewhere in recent days have focused their anger at current President Mohamed Morsy . The former Muslim Brotherhood leader , who became Egypt 's first democratically elected leader last year , has come under fire by some who compared him to Mubarak and said he amassed power for himself and his Islamist allies . He has insisted his moves were necessary to move Egypt forward in the face of pressing issues and persistent obstacles . On Friday -- the anniversary of what some call the January 25 Revolution -- six people were killed in Suez and one in Ismailia , amid clashes involving anti-government protesters and those supportive of Morsy , as well as police . Hundreds more were injured in the unrest nationwide . Journalist Ramy Francis and CNN 's Reza Sayah reported from Cairo ; CNN 's Amir Ahmed reported Atlanta . CNN 's Chelsea J. Carter contributed to this report .
The health ministry puts the casualties at 31 dead , more than 300 wounded . The roads in and out of Port Said have been closed . A man is carried away by his friends after being injured during clashes between protesters and police near Tahrir Square on February 2, 2011 Clashes between anti-government protesters and police are underway in Cairo , officials say .