Many of the best and most interesting roads in the U.S. run north to south , crossing the nation 's striations and taking you from northern weather and cultures to entirely different ones down south . Traverse 15 states along US 1 from Maine to Key West . Take US 89 from New Orleans to U.S. , stopping for blues in Minnesota . No U.S. highway hits more iconic national parks than US 61 .
Traverse 15 states along US 1 from Maine to Key West . Take US 89 from New Orleans to U.S. , stopping for blues in Minnesota . No U.S. highway hits more iconic national parks than US 61 .