( CNN ) -- A U.S. federal grand jury in Texas has indicted the suspected top leaders of Mexico 's Sinaloa cartel . Joaquin `` El Chapo '' Guzman Loera and Ismael `` El Mayo '' Zambada Garcia face murder and conspiracy charges connected with drug trafficking , money laundering and organized crime . The indictment , returned April 11 and unsealed Tuesday , also charges 22 other people who prosecutors allege are connected with the cartel . It is one of several U.S. federal indictments charging Guzman , who is widely known as Mexico 's most wanted fugitive and has made Forbes magazine 's list of the world 's most powerful people . `` It 's a reminder we 're right behind him , that he ca n't live out in the open . We need to get them apprehended , '' Assistant U.S. Attorney Tony Franco said Tuesday . This month 's indictment in western Texas detailed two acts of violence prosecutors said were committed by members of the cartel , including the 2010 kidnapping of an American citizen and two members of his family during a wedding ceremony in Ciudad Juarez , Mexico , because of their ties with the rival Juarez cartel . The target was the groom and a resident of Columbus , New Mexico , the U.S. Attorney 's Office for the Western District of Texas said in a statement . Police found the bodies of the groom , his brother and his uncle three days after the wedding in the bed of a pickup truck , according to the indictment . The indictment also describes the 2009 kidnapping , killing and mutilation of a Texas resident `` to answer for the loss of a 670-pound load of marijuana seized by the Border Patrol , '' prosecutors said . Investigators found the Texas resident 's body in Ciudad Juarez , according to the indictment . `` He had been beaten and strangled and his hands had been severed above the wrists and placed on his chest , to serve as a warning to those who might attempt to steal from the cartel , '' the indictment says . Guzman and Zambada have been indicted on drug trafficking and organized crime charges in a number of U.S. federal courts . U.S. officials have offered a $ 5 million reward for information leading to their capture . Guzman was arrested in 1993 on homicide and drug charges but escaped in 2001 , reportedly by bribing prison guards to smuggle him out in a laundry truck . A Mexican federal investigation led to the arrest of more than 70 prison officials . Forbes magazine has placed him on its list of the world 's most powerful people , reporting his net worth of $ 1 billion as of March . Rumors regularly surge about his whereabouts . Franco declined to comment on whether there was new information regarding Guzman 's location . He described Guzman as `` a man who has unlimited means , more money than most people in Mexico . '' `` It affords him the ability to hide , '' Franco added . The Sinaloa Cartel , named after the Mexican state where the gang was formed , is one of the most powerful drug-trafficking groups in the nation . CNN 's Ed Lavandera and Catherine E. Shoichet contributed to this report .
` ` It 's a reminder that we 're right behind ( ' El Chapo ' Guzman ) , '' a prosecutor says . The Sinaloa cartel 's suspected top gang members face murder and conspiracy charges . A grand jury also indicts three others accused of working for the cartel . Indictment details two violent crimes , including the kidnapping of American during his wedding .