` ` Monsters vs. Aliens '' is about motley crew of monsters who team up to fight alien . Monsters are led by almost 50-foot woman , voiced by Reese Witherspoon . Witherspoon says she hopes character can be role model for girls . Other actors and voices : Seth Rogen , Kiefer Sutherland , Will Arnett .
`` Monsters vs. Aliens '' is about motley group of misfits who team up to defeat alien . Monsters are led by almost 50-foot woman , voiced by Reese Witherspoon . Witherspoon says she hopes character can be role model for girls . Other actors lending talents : Seth Rogen , Kiefer Sutherland , Will Arnett .