( CNN ) -- Major League Baseball is set to suspend some 20 players in the coming weeks due to a scandal involving performance-enhancing drugs , according to an ESPN report that said a key figure in the case is now ready to cooperate with investigators . The network says it is potentially the worst drug-abuse case in the history of U.S. sports . The league declined to comment to CNN but confirmed that an investigation is in the works . The players union said Wednesday that players are being interviewed by baseball officials and are represented by attorneys . `` The commissioner 's office has assured us that no decisions regarding discipline have been made or will be made until those interviews are completed , '' the union said in a written statement . Baseball 's highest-paid player , New York Yankee third baseman Alex `` A-Rod '' Rodriguez , as well as Ryan Braun of the Milwaukee Brewers , are among those facing suspension , ESPN said , citing unnamed sources . Both have denied recently using performance-enhancing drugs , or PEDs . Rodriguez has admitted in the past to using banned substances when he played with the Texas Rangers in the early 2000s . A-Rod denies performance-enhancing drugs reports . The league may seek to ban the players for 100 games by counting the doping itself as one infraction and lying about having taken the drugs as a second one , ESPN reported . Major league players can appeal any possible suspensions , as Braun did in 2012 . That year , a drug test showed high levels of testosterone in his body , but the outfielder successfully disputed the testing process , and the suspension was overturned in February . Asked about the ESPN report Tuesday , Braun said he was sticking by his previous account . `` The truth has not changed , '' he told reporters , declining to comment further . CNN has not independently confirmed the ESPN report . A Florida newspaper first leveled doping allegations at Rodriguez in January . The Miami New Times reported that the shortstop and third baseman had acquired the drugs from a now-closed Miami anti-aging clinic called `` Biogenesis , '' run by Anthony Bosch . Twitter reacts to PED saga . ESPN said Bosch , who allegedly supplied baseball players with performance-enhancing substances , has agreed to cooperate in the MLB investigation . CBS Sports also confirmed Bosch will talk to investigators . Records obtained by MLB name many players , but league investigators need Bosch to attest to their accuracy and confirm that players were doping , ESPN reported , citing unnamed sources . The league filed a suit against Biogenesis in March for allegedly supplying PEDs to players and advising them on how to avoid detection during drug tests . ESPN reported that MLB may drop the suit against Bosch , if he cooperates in its investigation . MLB sues Florida clinic linked to supplying players with PEDs . Managers tight-lipped . On Tuesday , the managers for the Yankees and the Brewers said little . `` I know Major League Baseball is handling it , and that 's all I know , '' Brewers manager Ron Roenicke told journalists at a post-game news conference in Milwaukee . Yankees manager Joe Girardi started out dodging reporters who grilled him on ESPN 's report after New York 's game but softened when it came to his concerns about Rodriguez . `` I always worry about my players , always , '' he said . `` One thing you never want to forget is -- they 're human beings . '' In January : MLB expands testing for HGH , testosterone . He did not say whether he had discussed the looming scandal with Rodriguez . `` When I talk to Alex , it 's baseball-related . That 's what it is , '' Girardi said . He feared the game he has dedicated his life to will suffer because of the scandal . `` I worry about baseball being affected as a game , the whole thing , and what it 's been through in the last 15 years . '' What we 've learned : A complete timeline . Rodriguez was at the Yankees training facility in Florida on Tuesday , recovering from an injury . He could not be reached for comment . A 100-game suspension could cost him more that $ 15 million , ESPN reported . New York outfielder Vernon Wells was discouraged by the scandal . `` We 've done so much as a group to try to rid ourselves of conversations like this , '' he said . In spite of advances in drug testing , new doping techniques designed to avoid detection keep coming , Wells said . `` There 's always someone out there trying to beat the system from a medical standpoint . '' Baseball writers balk at Hall of Fame class of '13 .
Players union says MLB is interviewing players , who have attorneys . Ryan Braun sticks by his denial : `` The truth has n't changed '' ESPN : If the suspensions hold up , it could be the biggest scandal in U.S. sports history . Baseball 's highest-paid player , Alex Rodriguez , may face suspension .