( The Frisky ) -- I know you are really , really upset -- but can you stop crying for a second so we can talk about the fact that Katherine Heigl is finally leaving `` Grey 's Anatomy ? '' Long overdue , as far as I 'm concerned . She has been annoying me since day one . How bad can the job really be ? Hmmm , let 's see . You get paid hundreds of thousands of dollars to show up on set for 12 episodes -- then you get half the year off . Yeah , I think I 'd quit too . Her publicist claims she 's out of there because she wants to spend more time with her newly adopted daughter , and that becoming a mother has `` changed [ her ] desire to work full-time . '' That 's sounds like sunshine and moonbeams and all , but the truth is that she 's been petitioning to get Dr. Izzie Stevens written off for the last three years . Since her BFF T.R . Knight left , I suspect . At least we can have some fun imagining how they might get rid of her . Drug overdose ? Amnesia ? Doctors Without Borders ? Sex tape ? Fun ! Anyway , considering her last few movies were ludicrous rom-coms and she has a rep for biting the hand that feeds her , I 'm thinking she may not be too popular in Hollywood after this . Plenty of other celebs have left cushy TV jobs for bigger and better things . Let 's see how nine of them fared . The Frisky - Sandra Bullock and other celebs who ditched the dead weight . 1 . Amanda Seyfried thinks she 's too big for the filming schedule of `` Big Love . '' That 's why she 's leaving the show -- to move back to New York City , pursue her film career , and live life to the fullest by eating spinach and seeds and popping pills . Mazel Tov , Amanda ! But we 're not sure how this is going to go for you . 2 . Fans went crazy when ABC announced that it was canceling `` My So-Called Life '' after just one season . But then it came out that Claire Danes was the one who wanted the show to end -- she was ready to move on to a film career . She 's had some hits , `` Romeo & Juliet '' and `` Shopgirl , '' but she will always and forever be Angela Chase . 3 . She 's never confirmed it , but when `` The O.C . '' killed off Marissa Cooper in the season finale of season three , most people assumed it was because Mischa Barton wanted to move on . The show trucked on without her -- for a season . Mischa 's career , on the other hand : as dead as Marissa after the car wreck . Frisky - 8 female stars who dated their managers . 4 . Rose McGowan replaced Shannen Doherty when good witch Prue Halliwell was `` killed off '' of `` Charmed . '' Now she 's working her magic on the judges of `` Dancing With the Stars . '' Abracadabra ! Save my career ! 5 . Never thought I 'd say this , but I 'm actually glad that Tina Fey left `` SNL '' to go on to write , produce , and star in `` 30 Rock . '' Yeah , she 's pretty much taking over the industry and making money with much more than her looks . The Frisky -- Britney and J . Lo did it : How a `` How I Met Your Mother '' cameo can turn a career around . 6 . Hunky George Clooney left `` ER '' in its fifth season to become the A-list movie star in the front row at the Oscars . A winning move ? I 'd say yes . 7 . Nicollette Sheridan was so desperate to be polished like the jewel that she believed she was that she left `` Desperate Housewives . '' She called the show `` complacent , '' but creator Mark Cherry said her time was up because she had already slept with everyone on the show . Rumor has it that she has a new TV show coming out . Let 's see if that jewel shines . The Frisky - 10 stars whose relationships went sour after they found fame . 8 . Viewers cried and stuff when Kal Penn 's character on `` House '' committed suicide only to stop crying when they found out he 'd accepted a position at the White House . Because it 's nobler to actually help people than to play someone who does it on TV . 9 . While Kal Penn joined the real White House , Rob Lowe left the fictional one on `` The West Wing '' because he did n't think there was a place for his character , Democrat Sam Seaborn , anymore . And then he went on to play Republican politico Robert McCallister on `` Brothers & Sisters . '' Politics will eat you alive , man . TM & © 2010 TMV , Inc. | All Rights Reserved .
Claire Danes was the one who wanted `` My So-Called Life '' to end . The show is a comedy about two women in their early 30s whose lives are turned upside down when they discover that their husbands have been having an affair. to kill off her character . Heigl 's publicist says she 's leaving the show to spend more time with her daughter .