( CNN ) -- Kim Clijsters is looking forward to taking a break after her title reign at the Miami Masters ended at the quarterfinal stage . The 27-year-old , also the 2005 winner in Florida , could not repeat her heroic effort against Ana Ivanovic as she was beaten 6-3 6-3 by eighth seed Victoria Azarenka on Wednesday . The Belgian had saved five match-points before overcoming Ivanovic in the previous round , but admitted she was drained after stepping back on court less than 24 hours later . `` I just did n't feel good out there . Just mentally , physically , it did n't feel right , '' the Australian Open champion told the WTA Tour website . `` Physically it was tough the last few days , but I train hard enough to be capable of doing that . Nadal and Federer close on semi clash . `` Mentally I just did n't have any fighting spirit . It 's tough against someone like Victoria -- against some lower-ranked players it 's possible to get through matches , but not her . `` I 'm just looking forward to a break right now . It ca n't be long because we have Fed Cup in a couple of weeks , so probably a few days , get settled at home . '' Clijsters , who briefly reclaimed the No . 1 ranking from Caroline Wozniacki after reaching the final in Paris in February , could now lose second place after failing to reach the semifinals for the second successive event . Vera Zvonareva can move back above Clijsters if she wins the title at the U.S. hard-court event . The third seed will next play Azarenka , having beaten Polish No . 9 Agnieszka Radwanska 7-5 6-3 in her earlier quarterfinal . Zvonareva and Azarenka are the only players to have beaten Clijsters more than once since the three-time U.S. Open champion 's return from retirement in 2009 . Azarenka , who has a 2-6 losing record against the Russian , won the 2009 title in Miami but was beaten by Clijsters in Florida in the fourth round last year . This time she led 6-3 5-1 before Clijsters -- who made eight double-faults in losing her serve six times -- saved two match-points . `` She went for her shots and stayed in the match until the end . I knew it would be tough and I was ready , '' the Belarusian said . `` I have to play on a high level , because Vera is a very consistent player . She is showing some of the best tennis of her life right now , so I have to be aggressive and focused . '' The other semifinal , also to be played on Thursday , sees Zvonareva 's compatriot Maria Sharapova bid to reach her third Miami final against Germany 's Andrea Petkovic . Meanwhile , Novak Djokovic continued his hot run of form as he reached the semifinals of the men 's event with a 6-4 6-2 crushing of South Africa 's Kevin Anderson on Wednesday . The Serbian , who beat world No . 1 Rafael Nadal in the final at Indian Wells almost two weeks ago , is now undefeated in 22 matches this year . The world No . 2 lost to Anderson in the second round in Miami three years ago , but progressed in one hour and 48 minutes to give himself a chance of a second title in Florida -- having won in 2007 and finished runner-up to Andy Murray in 2009 . The 23-year-old will next face Mardy Fish , who has beaten in all five previous meetings , after the 14th seed eliminated Australian Open semifinalist David Ferrer in the day 's opening men 's match . Fish won 7-5 6-2 against the Spanish sixth seed to ensure that he will become the top-ranked American for the first time , above two-time Miami champion Andy Roddick , when the new list is released next week . Roddick 's title defense ended with a second-round defeat by 67th-ranked Uruguayan Pablo Cuevas last week . Fish is hopeful that he can beat Djokovic , who has not dropped his serve in the tournament and has lost only 14 games in four matches so far . `` He 's not going to win every single match this year . Whether it be this week or in July , he 's not going to win every one . It 's just not possible . So hopefully it can be me , '' the 29-year-old said . In Thursday 's men 's quarterfinals , two-time runner-up Nadal will take on Czech seventh seed Tomas Berdych while world No . 3 Roger Federer plays French 25th seed Gilles Simon as he seeks his third title here .
Victoria Azarenka ends Kim Clijsters ' hopes of a third title in Miami hard - court event . Belgian retired less than 24 hours after her epic three - set victory over Ana Ivanovic . Eighth seed Venus will play world No . 3 Vera Wang in the semifinals . Novak Djokovic through to men 's semis after his 22nd successive win this year .