( CNN ) -- Rafael Nadal 's hopes of successfully defending his U.S. Open title have been dealt a serious blow after the Spaniard revealed he has sustained a wrist injury during a practice session . The world No . 2 says he will be out of competitive action for `` at least two-three weeks , '' ruling him out of the upcoming ATP Tour 1000 events in Toronto and Cincinnati and possibly out of this season 's final grand slam tournament which starts on August 25 . Nadal won both Masters events last season before beating Novak Djokovic in the final at Flushing Meadows in New York . In a statement released by organizers of Toronto 's Rogers Cup , Nadal expressed his dismay at missing out this year . `` I 'm extremely disappointed that I am unable to defend my Rogers Cup title this year , '' said Nadal , who beat home favorite Milos Raonic in last year 's final . `` I was looking forward to coming there and playing again in Toronto as I have always loved to play in Canada and had great results in the past at a very important event . `` Unfortunately I injured myself yesterday ( Tuesday ) during practice and after checking with my doctors I will have to stay out of competition for at least two-three weeks . I am sorry to the tournament and to all of the fans . '' The 28-year-old last missed the U.S. Open in 2012 when a knee injury forced him out of action for seven months in total . Nadal has endured fluctuating fortunes on court this year winning four tournaments so far including the French Open in June . His four-set win over Novak Djokovic clinched a ninth title at Roland Garros , but this was tempered by disappointments at Melbourne Park and Wimbledon . At the Australian Open in January , Nadal injured his back in the warm up before the final and went onto to lose in four sets to Switzerland 's Stanislas Wawrinka . Normal service was resumed in Paris before Nadal exited early for the third year running at SW19 . After being dumped out in round 's two and one in 2012 and 2013 respectively , Nadal made it to the last 16 before succumbing to Australian teenager Nick Kyrgios . Read more : Serena fighting fit after Wimbledon illness scare .
Rafael Nadal to miss ATP Tour events due to wrist injury . World no . 2 withdraws from events in Toronto and Cincinnati . Spaniard now a major doubt for U.S. Open which starts on August 25 . Nadal 's doctors tell him he can not compete for `` at least two-three weeks ''