( CNN ) -- World number three Roger Federer avenged his loss in the 2009 U.S. Open final as he defeated Juan Martin del Potro 6-3 7-5 in the second round of the Western and Southern Open on Tuesday . Federer , a 16-time grand slam winner , managed to avoid a third-straight defeat to the 22-year-old , having previously lost to Del Potro at the 2009 ATP World Tour Finals . The Swiss broke Del Potro , ranked 19 in the world , once in each set and sealed victory in one hour and 32 minutes . `` I expected a tough match with Juan Martin for obvious reasons , and it went better than I thought , '' Federer , who is looking to win the Cincinnati event for a record fifth time , told the ATP Tour 's official web site . Can anybody stop Novak and Serena ? `` I thought I played a wonderful first set and a very good second set , too . That was obviously enough tonight . I do n't think I really allowed Juan Martin to be able to play the game he usually plays . '' Del Potro will now focus his attention on the U.S. Open , which gets underway on August 29 , where he will return for the first time since his triumph two years ago . Federer will face wildcard James Blake in the third round , after the American defeated Italy 's Fabio Fognini 6-4 6-2 . Czech fifth seed Tomas Berdych also sealed victory on Tuesday as he picked up his fifth-career win over Del Potro 's compatriot Juan Monaco . In the remaining first round matches that were played , Wimbledon semifinalist Jo-Wilfried Tsonga beat Croat Marin Cilic 6-3 6-4 . The 15th seed will play American qualifier Alex Bogomolov Jr. , who emerged from a clash with his wild card compatriot Robby Ginepri with a 6-4 6-3 success . In an all-Spanish encounter , ninth seed Nicolas Almagro advanced at the expense of Albert Montanes with a 7-6 ( 7-5 ) 6-4 triumph . Serbia 's world number 20 Viktor Troicki is through after a 6-0 3-6 7-6 ( 7-5 ) victory over French qualifier Edouard Roger-Vasselin in a marathon match which lasted two hours and 29 minutes .
Roger Federer has beaten Juan Martin del Potro at the Western and Southern Open . Wimbledon semifinalist Jo-Wilfried Tsonga defeated Croat Marin Cilic . There were also wins for Nicolas Almagro and Viktor Troicki .