` ` Monsters vs. Aliens '' is about a group of misfits who team up to defeat alien . They are led by almost 50-foot woman , voiced by Reese Witherspoon . I ca n't remember her name . ' Witherspoon says she hopes she can be role model for girls . Other actors and talents : Seth Green , Kiefer Sutherland , Will Arnett .
` ` Monsters vs. Aliens '' is about a group of misfits who team up to defeat alien . They are led by almost 50-foot woman , voiced by Reese Witherspoon . Witherspoon says she hopes she can be role model for girls . Other actors and talents : Seth Green , Kiefer Sutherland , Will Arnett .