( CNN ) -- AC Milan went top of Serie A for the first time this season with a 3-1 victory over Palermo in the San Siro as previous leaders Lazio lost 1-0 at newly-promoted Cesena Wednesday . Pato opened the scoring for Milan before Armin Bacinovic equalized for the Sicilians but a Zlatan Ibrahimovic penalty and late Robinho third gave Milan a comfortable win . Their joy was complete as city rivals and reigning champions Inter were held to a 1-1 draw at Lecce and drop to fourth . Diego Milito scored ony his third goal of the season on 76 minutes as he returns from injury , but Uruguayan Ruben Oliver leveled for Lecce just three minutes later . Napoli moved above Inter to third as Ezequiel Lavezz grabbed an injury time winner at Cagliari . Lazio were suffering their second straight defeat after going down to AS Roma in the capital city derby at the weekend . Marco Parolo scored the only goal of the game five minutes from time to sink Lazio . Turin giants Juventus are in fifth after a 1-1 draw at Brescia as Alessandro Diamanti equalized after Fabio Quagliarella 's opener . In Spain 's Copa Del Rey , Real Madrid thumped Real Murcia 5-1 at home to avoid the domestic cup upsets of recent seasons . The first leg had ended goalless . Esteban Granero 's early goal put Real ahead before Gonzalo Higuain 's controversial second , which saw Sergio Ramos clearly obstruct visiting goalkeeper Dani Hernandez from an offside position . Goals from Cristiano Ronaldo , Karim Benzema and Xabi Alonso settled the match in the Bernebeu in the second half . But Murcia scored a consolation through Pedro 's late penalty . Barcelona are also safely through to the next round , thrashing AD Cueta 5-1 at Camp Nou . Already 2-0 up after the first leg , goals from Nolito and Gabriel Milito gave the hosts a two-goal lead inside the first 10 minutes , although the visitors pulled a goal back through Guzman after 35 minutes . Spanish duo Pedro and Bojan Krkic both found the net before Argentine superstar Lionel Messi completed the rout with just over 20 minutes to go .
AC Milan go top of Serie A with 3-1 victory over Palermo in San Siro . Previous leaders Lazio lost 1-0 to Cesena for second straight loss . Champions Inter held to 1-1 draw at Lecce and drop to fourth . Real Madrid thrash Real Murcia 5-1 to progress in Copa Del Rey .