( CNN ) -- The United States must beat Guadeloupe on Tuesday to guarantee a quarterfinal place at the Gold Cup , having suffered a shock first group-stage defeat in the CONCACAF region tournament . Bob Bradley 's team go into the final match of pool play in Kansas on the back of Saturday 's 2-1 loss to Panama in Florida -- the nation 's first such Gold Cup setback in 27 matches and the first in nine encounters with the Central American side . `` I do n't think the heat was a factor . On the night we were not sharp enough , '' coach Bradley told the U.S. Soccer website . `` With the fast turnaround , we 're clearly going to consider some changes and be ready to go Tuesday night in Kansas City . '' Five Mexico stars banned after failing drugs test . Panama led 2-0 with first-half goals from Luis Tejada and Gabriel Gomez , the latter a penalty after Tim Bream fouled Blas Perez . Striker Clarence Goodson reduced the deficit in the 68th minute when Michael Bradley flicked on Landon Donovan 's corner , but the four-time Gold Cup champions could not manage an equalizer . The win put Panama on top of Group C with two victories from two ahead of the final match against Canada , who are level with the U.S. on three points after beating 10-man Guadeloupe 1-0 . Jean-Luc Lambourde was sent off in the fourth minute after a foul on Will Johnson , while Dwayne De Rosario scored the winner from the penalty spot in the 51st minute after Stephane Zubar was booked for fouling Ali Gerba . The Panamanians lost to the U.S. in the 2005 final after a penalty shootout , and reached the quarterfinals in 2007 and 2009 . In Sunday 's Group A games , defending champions Mexico take on second-placed Costa Rica having already qualified for the last eight after two successive 5-0 wins . However , Mexico 's hopes have been hit by the suspension of five players -- Guillermo Ochoa , Francisco Javier Rodriguez , Edgar Duenas , Antonio Naelson `` Sinha '' and Christian Bermudez -- who tested positive for the banned drug clenbuterol . To finish second , El Salvador -- whose only point came in a 1-1 draw with Costa Rica -- must beat bottom nation Cuba by 11 goals and see the 2009 semifinalists lose to five-time champions Mexico . Group B concludes on Monday , with Jamaica already through to the quarterfinals after two victories ahead of the clash with second-placed Honduras in New Jersey . Third-placed Guatemala , who have only one point , must beat bottom nation Grenada by a big margin and hope the Hondurans lose .
U.S. national football team needs win over Mexico to reach last place at World Cup . CONCACAF tournament hosts beaten by Panama for the first time on record . Panama on top of Group C with two victories from two games . Canada level with Canada on three points after North American team beat Guadeloupe .