( CNN ) -- French club Lyon kept up their hoodoo over Real Madrid with a 1-0 win on Tuesday night as the Spanish giants face the prospect of exiting Europe 's premier competition at the last-16 stage for the sixth successive season . Lyon will take a narrow lead into the second leg of the Champions League tie thanks to a stunning second-half strike from Jean Makoun . Real , who have lost their last three trips to the Stade Gerland without scoring a goal , will battle to overturn the deficit next month at their Santiago Bernabeu Stadium -- which will host the final in May . Madrid president Florentino Perez spent a fortune on players such as Cristiano Ronaldo and Kaka in pre-season with the stated goal of winning the Champions League , as the club did in his first reign , and ending the dominance of rivals Barcelona . But coach Manuel Pellegrini has seen his side languish in second place to Barca in La Liga and suffer an embarrassing exit from the Copa Del Rey , so will be hoping his expensive legion of stars can bounce back from this defeat . After both sides went close with several half-chances , Lyon almost took the lead five minutes before halftime when winger Cesar Delgado lashed a volley against the left-hand post as Miralem Pjanic 's corner was only half-cleared . Two minutes after the break , Cameroon midfielder Makoun was allowed to surge to within 25 meters of the Real goal and he fired a right-foot effort that sailed past keeper Iker Casillas and into the top corner of the net . Ronaldo went close for Real with a deflected effort from similar distance , but the visitors were almost caught on the counter-attack as Casillas did well to deny Aly Cissokho . Gonzalo Higuain tested Lyon goalkeeper Hugo Lloris before being replaced by former Lyon star Karim Benzema with 15 minutes left , but Real were unable to force an equalizer .
French club Lyon open up their lead over Real Madrid with 1 - 0 home win . Jean Makoun scores only goal of Champions League last-16 , just after halftime . Real have lost last three matches without scoring a goal at Lyon 's Stade Gerland . Second leg is next month at Madrid 's Santiago Bernabeu , which hosts the final in May .