( CNN ) -- Holders Inter Milan are through to the quarterfinals of the Italian Cup , defeating Genoa 2-1 at the San Siro despite coach Claudio Ranieri resting a host of key players . Goalkeeper Julio Cesar , defenders Lucio and Walter Samuel and strikers Diego Milito and Giampaolo Pazzini were among those given a night off by Ranieri , but Inter still proved too good for their rivals , who also made a host of changes to their side . Inter took the lead in the ninth minute when Brazilian defender Maicon let fly with a superb 25-yard shot that gave Cristiano Lupatelli no chance in the Genoa goal . Who are football 's top January transfer targets ? And the home side doubled their lead five minutes after the break when Andrea Poli played a one-two with Joel Obi before volleying home his first goal for the club . Genoa pulled a consolation goal back in injury time when Lucas Pratto 's shot hit the crossbar and Valter Birsa reacted first to score from close range . But Inter held on for victory and they now face a tricky trip to Napoli in next week 's quarterfinal tie . The other last eight matches see Juventus entertain Roma , Chievo face Siena and Milan take on Lazio . Meanwhile , in Spain , Valencia look to have booked their place in the semifinals of the Copa del Rey after beating Levante 4-1 in their quarterfinal first leg . Goals from Jonas , Roberto Soldado , Pablo Piatti and Tino Costa have put Valencia in a strong position ahead of next week 's second leg tie .
Holders Inter Milan are through to the quarterfinals of the Italian Cup . Goals from Maicon and Andrea Poli give Inter a 2-1 win over Genoa . Inter will now face Napoli for a place in the semifinal of the competition . Valencia defeat Levante 4-1 in the first leg of Copa del Rey quarterfinal .