( CNN ) At least 23 people have died this week in the United States due to winter weather , CNN has confirmed . A majority of the deaths -- 18 -- occurred in Tennessee . Three of those people died in a fire in Knox County , Tennessee emergency management officials said . Family members said a man , woman and their adult son died in the fire , according to CNN affiliate WATE . Firefighters said they had difficulty reaching them because the second level of the house collapsed onto the lower level , WATE reported . Other people in Tennessee died from hypothermia and in auto accidents , WATE said , and a dialysis patient died after he was unable to get treatment because of weather . More than 2,700 people are without power as more severe cold , freezing rain and snow are predicted for the next few days , Tennessee officials said . Dangerously cold conditions continue to grip a large part of the Eastern United States , CNN meteorologists said , with more than 125 million Americans under a wind chill warning or advisory . Wind chills will go as low as 40 below zero in some places . Snow , sleet , and freezing rain will spread over the mid-South and into the mid-Atlantic over the next couple of days . Ice storm warnings are in effect for Nashville , where heavy ice accumulation could again cause widespread power outages . Winter storm warnings again cover much of Kentucky , which saw as much as 15 inches from the last storm . More heavy snow is predicted for Louisville and Cincinnati . The storm will spread up the East Coast this weekend . CNN 's Mayra Cuevas contributed to this report .
18 people died in Tennessee , emergency management officials say . Dangerously cold conditions continue to grip a large part of the Eastern U.S .