( CNN ) -- Some heartburn medications could increase the risk of hip , wrist and spine fractures in high doses or with long-term use , the Food and Drug Administration warned . Such so-called proton pump inhibitors are used for the treatment of gastroesophageal reflux disease , stomach and small intestine ulcers and inflammation of the esophagus , along with frequent heartburn . They include esomeprazole , sold under the brand name Nexium , dexlansoprazole ( Dexilant ) . lansoprazole ( Prevacid ) , omeprazole ( Prilosec , Zegerid ) , pantoprazole ( Protonix ) and rabeprazole ( Aciphex ) . Over-the-counter versions include omeprazole ( Prilosec OTC , Zegerid OTC ) and lansoprazole ( Prevacid 24HR ) . The product labeling will be changed to describe the possible increased risk , the FDA said in a statement Tuesday . `` Epidemiology studies suggest a possible increased risk of bone fractures with the use of proton pump inhibitors for one year or longer , or at high doses , '' said Dr. Joyce Korvick , deputy director for safety in FDA 's Division of Gastroenterology Products . `` Because these products are used by a great number of people , it 's important for the public to be aware of this possible increased risk and , when prescribing proton pump inhibitors , health care professionals should consider whether a lower dose or shorter duration of therapy would adequately treat the patient 's condition . '' The warning and revised labeling stems from the FDA 's review of several studies that reported an increased risk of hip , wrist and spine fractures in people using proton pump inhibitors . The warnings and precaution sections of prescription labels and the drug facts label on over-the-counter medications will address the findings , the agency said .
Some heartburn , these medications carry risk of fractures , FDA warns . Increased risk occurs with high dose , long - term use . Warning for both prescription and over - the - counter medications . Drugs include some types of popular medications Prilosec , Nexium , Prevacid , others .