( CNN ) -- Titleholders Inter Milan will take on Bayern Munich in the last 16 of the Champions League after Friday 's draw produced a repeat of last season 's final . Italian side Inter went into the pot knowing that a tie with one of Europe 's top sides was likely after qualifying for the knockout stages in second place in Group A behind Tottenham . `` It 's an interesting draw , '' Inter chairman Massimo Moratti told the club 's official website . `` We 've faced Bayern Munich lots of times in the past , it 's almost a traditional fixture . '' Rafael Benitez 's side will have home advantage for the first leg , which will be played in February , while the trip to Germany will take place in March . Bayern , beaten 2-0 in May 's final when Jose Mourinho was in charge of Inter , have struggled in the Bundesliga but topped Group E with five wins from six matches . `` Inter is an extremely tough draw . Probably the most difficult draw open to us , '' Bayern chairman Karl-Heinz Rummenigge told the club 's website . `` But it 's also a very appealing draw for us . This is now our chance to take revenge . '' Barcelona will play English club Arsenal in a repeat of the 2006 final and last season 's quarterfinals , both of which were won by the Spanish champions . `` Difficult but possible , '' was Arsenal manager Arsene Wenger 's reaction to the draw . `` I did n't want anybody really , all teams would have been difficult , '' he told his club 's official website . `` Barcelona are certainly the favorites but they did not want us either because they know they will get a game . '' Barca 's Spanish rivals Real Madrid have the chance to avenge last season 's second-round defeat by French club Lyon , who went on to reach the semifinals . Mourinho will seek to take his expensively-assembled team past the last-16 stage for the first time since 2004 as Real bid for a 10th title . Madrid legend Emilio Butragueno , who was present at the draw , believes his former club will reach the later stages of the competition this year . `` This is a cruel but thrilling competition . We drew Lyon and must accept it , '' he said on Real 's website . `` We must be very focused . We are more than capable of making the quarterfinals . '' English club Tottenham 's reward for finishing top in Group A in their first appearance in the competition is another trip to Italy to face AC Milan . The Serie A leaders , who finished second behind Real in Group G , are seeking an eighth title , having last won it in 2007 . Tottenham manager Harry Redknapp described the match as a `` great challenge . '' `` I said before the draw that I would n't mind playing AC Milan , '' he told the London side 's website . `` You want to take on the best teams in the world , and that 's what the fans want to see as well . '' Three-time champions Manchester United will travel to France next month for the first leg against 1993 winners Marseille . Manager Alex Ferguson told the United website it would be a `` difficult tie '' . `` Marseille are a handful at their own ground , their fantastic atmosphere and incredible support guarantees that . They 've had a good change in fortunes in the last two or three years , '' he said . English rivals Chelsea , who also topped their group , will face Copenhagen -- the first Danish team to reach the knockout stages after finishing second in Group D behind Barcelona . But Chelsea chief executive Ron Gourlay said the Premier League champions would not underestimate their opponents . `` 'There 's no easy games at this stage and we 'll be very careful , '' he told the club 's website . Shakhtar Donetsk will also face a last-16 tie for the first time after topping Group H ahead of Arsenal , and the Ukrainian side will travel to the Italian capital to play AS Roma in next month 's first leg . German club Schalke , who topped Group B ahead of Lyon , will travel to Spain for the first leg of their second-round clash with Valencia -- second behind Manchester United in Group C. Champions League last-16 draw . AS Roma ( Italy ) v Shakhtar Donetsk ( Ukraine ) AC Milan ( Italy ) v Tottenham ( England ) Valencia ( Spain ) v Schalke ( Germany ) Inter Milan ( Italy ) v Bayern Munich ( Germany ) Lyon ( France ) v Real Madrid ( Spain ) Arsenal ( England ) v Barcelona ( Spain ) Marseille ( France ) v Manchester United ( England ) Copenhagen ( Denmark ) v Chelsea ( England ) First leg to be played on February 15-16 and 22-23 Second leg on March 8-9 and 15-16 .
Bayern Munich handed chance to avenge Champions League final defeat . German champions will take on titleholders Inter Milan in the second round . Barcelona drawn with Arsenal in repeat of last season 's quarters and 2006 final . TL;DR Real Madrid beat Atletico Madrid, 4-2, at Camp Nou for first time since 2009.