( CNN ) -- Real Madrid crashed to a shock 2-1 defeat to city neighbors Getafe in the second round of the Spanish La Liga season Sunday . After being held 1-1 by Valencia in their opener , Jose Mourinho 's champions are left with a solitary point after two games , trailing arch rivals Barcelona by five points . Gonzalo Higuain put Real ahead after 26 minutes and they appeared set for a routine derby victory . But Juan Valera was unmarked as he headed Getafe level after 52 minutes from a free kick . Real 's star-studded attack led by Cristiano Ronaldo pressed for the winner , but it was the home side who grabbed their second with Abdelaziz Barrada scoring in the 74th minute after an assist by Adrian Colunga . Earlier , Lionel Messi came to Barcelona 's rescue with a late double as they beat Osasuna 2-1 to go top of the standings on goal difference from Rayo Vallecano after two games . New Barca coach Tito Vilanova had been sent off for complaining to the referee as they trailed to a 17th-minute goal from Joseba Llorente . The former European champions had wasted a string of chances until Messi struck in the 75th and 80th minutes . Osasuna 's Francisco Punal was shown red for his protests after Messi 's first goal , claiming he was offside . Barcelona and Real Madrid will resume their rivalry Wednesday as the Catalans take a 3-2 lead to the Santiago Bernabeu after first leg of the Spanish Super Cup . In Serie A , the start of the season has seen contrasting fortunes for the Milan clubs . AC Milan , runners-up last season , lost 1-0 in the San Siro to newly promoted Sampdoria with Andrea Costa scoring the winner in the second half . But Inter Milan showed their city rivals how it should be done with a 3-0 win at another promoted side , Pescara , to top the early standings with Napoli , who won 3-0 at Palermo . On Saturday , Juventus began their defense of the title with a 2-0 victory at home to Parma .
Real Milan beaten two -1 by Getafe in La Liga . Goals from Juan Valera and Juan Valera sink champions . Barcelona top table after coming from behind to beat Osasuna . Contrasting fortunes for La Liga clubs in Barcelona start .