Denise Borino - Denise Borino-Quinn , who played the wife of a mob boss in the award-winning HBO series `` The Sopranos , '' has died of cancer at 46 . She played the wife of mob boss Johnny Russo . She won the role in an open casting call in 2000 . The cause of death was cancer .
Denise Borino - She played the wife of mob boss Johnny Russo . She won the role in an open casting call in 2000 . The cause of death was cancer .