( CNN ) -- Benfica has one foot in the quarterfinals of the Europa League after beating Tottenham Hotspur 3-1 in the first leg of their last 16 tie at White Hart Lane on Thursday . After being thumped 4-0 by Chelsea at Stamford Bridge in the English Premier League last weekend , Spurs manager , Tim Sherwood bemoaned his players ' lack of character and guts . If he was hoping for a response after the public dressing down , he did n't get one as Spurs produced another error-strewn performance . The visitors opened the scoring after 29 minutes when Ruben Amorim 's through-ball set Rodrigo free down the right before the Spanish striker unleashed a clinical left-foot finish past goalkeeper Hugo Lloris . Amorim helped earn the Portuguese side 's second of the night after catching Spurs striker Harry Kane in possession yards outside his own penalty area . The midfielder 's snap shot was then tipped over the bar by Lloris . But there was nothing the French keeper could do from the resulting corner as an unmarked Luisao headed home to double the lead with just under an hour played . Christian Eriksen halved the deficit with a brilliant free kick in the 64th minute to give the home fans some hope of a revival , but it was Jorge Jesus ' side who continued to look more threatening in attack . Benfica 's persistence paid off with six minutes remaining as former Brazilian international Luisao scored his second and his team 's third of the night . The defeat was Spurs ' first at home in 11 European fixtures while last year 's runners up stretch their winning run to five in the competition . There was also joy for FC Porto who beat Rafael Benitez 's Napoli 1-0 at the Estadio do Dragao . Benitez , who guided Chelsea to glory in the competition last season , will require all his famed tactical nous in the return leg next Thursday after Colombian striker Jackson Martinez 's 57th minute strike handed Porto the advantage . Over in Bulgaria , Benitez 's old club Valencia -- who he steered to the UEFA Cup success in 2004 -- has all but booked a place in the quarterfinals after a 3-0 against Ludogorets Razgrad in Sofia . The visitors won convincingly despite having Seydou Keita sent off in the 25th minute for a foul on Roman Bezjak inside the penalty area . Bezjak could n't convert the spot kick and Valencia , who were already a goal to the good thanks to Antonio Barragan 's fifth minute strike , made the most of the slip , despite the numerical disadvantage . Fede Cartabia doubled the lead in the 33rd minute before Philippe Senderos put the match , and most probably the tie , beyond the Bulgarians with a third away goal . Elsewhere , Switzerland 's FC Basel drew 0-0 with Austrian side Salzburg while the all-Italian clash between runaway Serie A leaders Juventus and fourth-placed Fiorentina ended in a 1-1 draw . In the all-Spanish tie , Real Betis , who are anchored at the foot of La Liga , recorded a fine 2-0 win at seventh-placed Sevilla . French side Lyon has almost guaranteed passage through to the last eight with a comprehensive 4-1 win over Czech side Viktoria Plzen while Dutch side AZ Alkmaar will take a slender advantage into the second leg against Russia 's Anzhi Makhachkala after winning the first leg 1-0 at the AFAS Stadion . Read more : Cantona arrested on suspicion of assault . Read more : Karembeu - France can shine in Brazil .
Benfica beat Tottenham Hotspur 3-1 in first leg of last 16 Europa League tie . Porto beat Napoli 1-0 ; Real Betis beat Sevilla 2-0 . Atletico Madrid draw with Malaga 0-0 at home to avoid defeat against Getafe.