( CNN ) -- Barcelona 's week went from bad to worse Saturday . Three days after it was ousted by Atletico Madrid in the Champions League quarterfinals , Barcelona lost 1-0 at lowly Granada in Spain 's La Liga to give Madrid 's second club a huge boost in the title race . Atletico can move four points clear of Barcelona on Sunday , a lead that would render the teams ' clash on the final day of the season meaningless -- if Real Madrid is out of contention . Real Madrid replaced Barcelona in second by defeating Almeria 4-0 at home later Saturday but was still without the injured Cristiano Ronaldo . Real Madrid has 79 points to match Atletico , though trails through head-to-head record and has played a game more . A combination of inspired goalkeeping by backup Orestis Karnezis and Barcelona misses -- from the likes of Lionel Messi , Neymar and Andres Iniesta -- ensured a night of frustration for Tata Martino 's men , who must pick themselves up in time for Wednesday 's Copa del Rey final against Real Madrid . A headline on Barcelona 's website Saturday proclaimed , 'The ball did n't want to go in . ' Barcelona registered nearly 30 shots but only one player scored in the game : Yacine Brahimi in the 16th minute . Granada entered Saturday three points above the relegation zone . `` This is a step backwards , '' Iniesta told Canal Plus . `` Sometimes it 's hard to find an explanation when you lose but we just could n't get the goal . `` Teams like Granada who are playing for their La Liga survival live and die on chances like the one they scored but that was too much punishment for us . `` We tried everything we could to score . It hurts having taken this step backwards with so few matches left . '' Surging Atletico visits third-last Getafe on Sunday , hoping to take three more points . Getafe has won once in the league since the end of November . Dortmund wins the German classic . After winning the league title in record time in late March , Bayern Munich lost its lengthy unbeaten streak , lost in the league for the first time this season and , some would say , struggled to eliminate Manchester United in the Champions League quarterfinals . Saturday saw another wobble , as Bayern Munich was soundly beaten by Borussia Dortmund 3-0 at home in Germany 's biggest club game . For Dortmund , meanwhile , it was the perfect response to exiting in the Champions League this week to Real Madrid . Henrik Mkhitaryan -- guilty of a miss or two against Real Madrid in the second leg when another Dortmund goal would have forced extra time -- Marco Reus and Jonas Hofmann scored for Dortmund . Bayern Munich ended the evening with 10 men after Rafinha was given a straight red for striking Mkhitaryan in the face in added time but worse news for Bayern was keeper Manuel Neuer 's calf injury . He had to be substituted at halftime . Bayern and Dortmund are expected to meet again this season , in the German Cup finale .
After exiting in the Champions League quarterfinals , Almeria loses in Granada 1-0 . Barca beaten by relegation threatened Granada 1-0 on the road on Wednesday . Real Madrid takes over second spot from Barcelona , downing Almeria 3 -0 . In Bayern Munich , Bayern Munich is humbled 3 -0 at home by Borussia Dortmund .