( CNN ) -- For the first time in two years there will be a winner of a Masters 1000 event who is not ranked in the `` Big Four '' after Andy Murray suffered a shock defeat in Paris on Thursday . World No . 3 Murray , who was the highest ranked player remaining in the draw , squandered a match point before going on to lose to Poland 's Jerzy Janowicz . Halloween horror for 'Darth ' Djokovic . Murray had been expected to lift the trophy in the French capital after Novak Djokovic 's defeat and the withdrawals of Roger Federer and Rafael Nadal . But he somehow contrived to snatch defeat from the jaws of victory after allowing Janowicz , ranked 69 in the world , to emerge triumphant . The hard-hitting Pole looked to be heading out of the tournament when Murray served for the match in the second set . But the Olympic and U.S. Open champion fluffed his lines and from serving for the match at 7-5 5-4 and 40-30 , he capitulated in dramatic circumstances to lose the second set 7-6 . The Briton was then swept aside 6-2 in the final set and will now head to the end of season finals in London which begins on Monday . It is the third consecutive tournament where Murray has lost after holding match points . Djokovic beats Murray in classic Shanghai final . Murray was beaten by Canada 's Milos Raonic in the last four at the Japan Open in Tokyo after holding two chances to win , while he also went down to Djokovic in Shanghai after failing to convert five opportunities . `` I did n't play a particularly good game and missed a couple of shots that I would have hoped to have made , '' Murray said on the ATP website . `` He probably gained some confidence from that and started playing better . He played a good tie-break , played aggressive . `` I have to make sure I tighten that up next week , if I get that opportunity in the matches . Make sure I do n't let it happen at The O2 . '' Janowicz , who had already beaten Philipp Kohlschreiber and Marin Cilic before defeating Murray , has enjoyed a stellar year and will now hope to make the semifinals when he faces Janko Tipsarevic -- who clinched the eighth and final place for the season-ending championships . `` In the beginning of this year , I had many changes in my life , '' Janowicz said . `` I changed the racquet . This racquet which I 'm using right now is helping me a lot . Even if I have some weak days , this racquet is actually helping me . So this is one change . `` The second one is , I have a new fitness coach this year , and he 's helping me a lot . I 'm doing a lot of fitness . When I 'm at home I 'm actually doing more fitness than tennis . `` So there is this other change . My behavior on the court is also a little bit different . I decided not to give up , whatever the situation is . I 'm fighting right now for every single ball . '' Federer to surrender world No . 1 ranking after pulling out of Paris Masters . There was also another shock as home favorite Michael Llodra overcame seventh seed Juan Martin Del Potro of Argentina . Former U.S. Open champion Del Potro , who has already booked his place at next week 's end of season finals in London , went down 6-4 6-3 to the 32-year-old left-hander . Tipsarevic , who played in London last year as an alternate when Murray pulled out with an injury , ensured his second appearance by defeating Juan Monaco 6-3 3-6 6-3 . `` The World Tour Finals last year was one of my best experiences ever on the tennis court . `` I was always dreaming of playing the World Tour Finals and I 'm excited to be back there , '' the Serbian said . Elsewhere , the 2005 Paris champion Tomas Berdych overcame big-serving South African Kevin Anderson 1-6 6-3 6-4 to secure his place in the quarterfinals . Berdych , who will also play in London next week , will now face France 's Gilles Simon after his opponent , Japan 's Kei Nishikori , withdrew with an injury . World No . 8 Jo-Wilfried Tsonga guaranteed his place in London after defeating Spain 's 11th-ranked Nicolas Almagro 7-6 ( 7-4 ) 7-6 ( 7-3 ) . `` It 's really important for me to have qualified , '' said the Frenchman , who will next face world No . 5 David Ferrer following the Spaniard 's three-set win over Stanislas Wawrinka . `` With the big four at the moment , it 's not easy to get rewards in tennis , so for me this is one of my rewards . It feels good to be a part of it . `` I have some great memories from last year where I played the final against Roger . It was huge for me , one of the big moments of my career . '' Canada 's world No . 13 Milos Raonic was dumped out at the third-round stage after going down 6-3 7-6 ( 7-1 ) to Djokovic 's conqueror , American Sam Querrey -- who will play Llodra in the last eight .
Andy Murray beaten by Poland 's Jerzy Janowicz.in third round of Madrid Masters . First time in past two years that a Masters 1000 winner will come from outside the top 10 . Argentina 's Martin Del Potro suffers shock defeat by France 's Michael Chang . Janko Tipsarevic keeps London dreams alive by defeating Juan Monaco in three sets .