Islamabad , Pakistan ( CNN ) -- A suspected U.S. drone strike killed 16 people and wounded six Thursday in one of Pakistan 's semi-autonomous tribal regions , two officials said . The attack , which included four missiles , targeted a compound on the border of Orakzai Agency and North Waziristan , a local government official and a military official said . The compound belonged to Maulvi Shakirullah , a militant affiliated with the Haqqani network , the officials said . The network is widely viewed to be fueling the insurgency in Afghanistan . Pakistan 's Geo TV , a CNN affiliate , also reported that the drone `` fired four missiles at a madrasa , '' or seminary , run by Shakirullah . A previous drone strike in the Orakzai agency in 2009 killed 11 suspected militants from a faction of the Pakistani Taliban . The United States carries out drone strikes in Pakistan aimed at dismantling terror operations , but generally does not comment on them . U.S. activists in Pakistan to protest drone strikes . 5 killed in first drone strike since protest march . Read more : Why U.S. will live to regret drone strikes .
The strike targeted a militant 's home , officials said . The officials say the militant is affiliated with the Haqqani network . The U.S. carries out drone strikes in Pakistan but generally does not comment .