( CNN ) -- Andy Murray is focused on winning his first grand slam title , but the Olympic tennis champion is facing new distractions following his success at London 2012 . `` Yeah , it 's been a bit weird , with people hanging out in front of my hotel room , taking pictures , '' the world No . 4 said after becoming the first player to reach the third round of the men 's draw at the 2012 U.S. Open . `` Some ask strange questions : What did I think of Prince Harry 's hotel photos ? What do I think about the Crown Jewels ? '' `` I said , no comment . It 's a little different than what I 'm used to , but it 's fun . '' Murray , seeded third in the absence of the injured Rafael Nadal , defeated Croatia 's Ivan Dodig on Wednesday for his second successive straight-sets victory in New York this week . Clijsters ' singles career ends after shock U.S. Open defeat . The Scot will next face either 30th seed Feliciano Lopez or his fellow Spaniard Pablo Andujar . `` It was better than the first round , that 's for sure . I moved better than I did in the first match and served better , and I was able to dictate more of the points because of that . I was much happier with the way I played , '' said Murray who lost in the 2008 final at Flushing Meadows . Spanish fourth seed David Ferrer won his opening match in three sets , beating big-serving world No . 34 Kevin Anderson of South Africa . Ferrer , who reached the semifinals in 2007 , faces into a second round meeting with 78th-ranked Dutch debutant Igor Sijsling . `` It was not an easy match with Anderson , '' Ferrer said . `` He 's a really good player . He has very strong first and second serve . I 'm happy , because I played well in my first round . '' American ninth seed John Isner won a tough first-round encounter with experienced Belgian Xavier Malisse , winning 6-3 7-6 5-7 7-6 in just under three hours as the fourth-set tie-break went to 13-11 . `` I wish I could make it easier on myself but I tend to not do that , as a lot of people know , '' said Isner , a quarterfinalist last year . He will next face another seasoned campaigner in Finland 's Jarkko Nieminen , who also reached the last eight back in 2005 . Seventh seed Juan Martin del Potro booked a second-round clash with young American Ryan Harrison after defeating France 's Florent Serra . The Argentine , U.S. Open champion in 2009 , battled to a 6-4 7-6 ( 7-4 ) 6-4 victory in two and a half hours against his 116th-ranked opponent , who has never got past the second round in New York . The 20-year-old Harrison , who lost his first-round match last year , matched his 2010 debut achievement by beating Germany 's Benjamin Becker in straight sets . Serbian eighth seed Janko Tipsarevic became the seventh man at this year 's tournament to win after dropping the first two sets , having faced a shock defeat at the hands of world No . 129 Guillaume Rufin . Tipsarevic , whose quarterfinal achievement last year was his best result at a grand slam , finally triumphed in three hours 37 minutes against the 22-year-old Frenchman . He will next face American Brian Baker , who continued his fairytale comeback by winning his first match at the tournament since his last appearance seven years ago . The former second-ranked junior player had multiple surgeries which wrecked his career , and had been coaching tennis at Belmont University when he decided to return to the professional tour this year . Baker , who made it to the second round at the French Open and the last 16 at Wimbledon , beat Czech Jan Hajek in straight sets in the opening match of his home slam . `` I had some nerves . I do n't think it was probably the prettiest match ever . A win is a win , '' said the 27-year-old , now ranked 70th despite still studying for a business degree and continuing his coaching role at Belmont . `` I think just getting out and not having played the U.S. Open in seven years and having expectations and having a lot of friends and family just gives you ... I mean , it 's good nerves . `` I think it helps you focus a little bit more and want it a little bit more , but it was exciting time to be back after so much time off . '' Veteran German 21st seed Tommy Haas , a three-time quarterfinalist , lost to Latvia 's Ernest Gulbis , while Russian No . 28 Mikhail Youzhny also blew a two-set lead as he was beaten by Luxembourg 's Gilles Muller . Muller , who reached the last 16 in 2011 , earned a clash with Australia 's former world No . 1 Lleyton Hewitt , who is expected to retire after the tournament . Hewitt , the 2001 champion and a three-time semifinalist , beat young German Tobias Kamke 4-6 6-2 6-1 6-4 .
Andy Murray becomes first man through to third round at the Australian Open . Spanish fourth seed David Ferrer eases through to second round . Eighth seed Janko Tipsarevic comes from two sets down to break through . He next faces Brian Baker , who wins first U.S. Open title in five years .