Twenty stakeholders, including major biopharmas, diagnostic players and academic institutions, have committed to creating what they expect will be the largest liquid biopsy open database for cancer genomic profiling data. It’s part of the broader ongoing Cancer Moonshot effort led by U.S. Vice President Joe Biden. The newest component is known as the Blood Profiling Atlas Pilot. It’s intended to serve as the basis for the development of blood-based cancer diagnostic technology standards. It aims to have sufficient controls that the FDA will recognize the database as a valid source of scientific evidence. The initial participants said they will contribute raw data sets from 13 different studies for further analyses. These data will span circulating tumor cells, circulating tumor DNA, and exosome assays, as well as clinical diagnoses, treatment history and outcomes, sample preparation and handling protocols. Virtual Clinical Trials Online This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance. Among the major biopharmas, AstraZeneca ($AZN), Eli Lilly ($LLY), Pfizer ($PFE), Novartis ($NVS), and Roche’s Genentech ($RHHBY) are all participating in that data effort. Specifically, Lilly will be profiling exosomes for mRNA and noncoding RNA expression. It plans to share sample preparation methods, next-generation quantitative PCR-based methods, and next generation sequencing-based methods as well as data related to disease characterization through gene expression analysis. "Liquid biopsies are going to be critical in the future to both identify specific patients for targeted therapies and to follow their treatment to better determine response to therapy,” said Lilly medical fellow Dr. Andrew Schade in a statement. “We hope knowledge gained from our research efforts in this area will help to accelerate the development of safe and effective blood profiling diagnostic technologies that help people with cancer." Bristol-Myers Squibb ($BMY) Foundation is donating $25 million over the next two years toward a separate research project specifically designed to help alleviate cancer inequities. It has awarded the first five grants, including a $10 million one to underserved cancer care group Project ECHO (Extension for Community Healthcare Outcomes). Celgene ($CELG) is pitching in with an associated crowdsourced challenge that will be run by Sage Bionetworks. It’s backing a $150,000 challenge designed to bring a diverse group of scientists together to share predictive models in an open-access environment. Diagnostic players Guardant Health, Thermo Fisher Scientific ($TMO), Epic Sciences and Foundation Medicine ($FMI) are also contributing data to the atlas. For its part, Guardant said it would offer data from 500 lung cancer patients who had been tested with its Guardant 360. "Our goal, since we started Guardant Health, was to decode cancer to conquer cancer,” said Guardant co-founder and President AmirAli Talasaz in a statement. “Having built the world's largest database of advanced-cancer profiling information, we are now in a position to use this information to help fulfill the Moonshot."
A liquid biopsy open database will be created as part of the Cancer Moonshot project, led by US Vice President Joe Biden. 500 stakeholders, including major biopharmaceutical firms and academic institutions, have committed to the Blood Profiling Atlas Pilot. It is hoped the project will lead to the development of blood profiling diagnostic technology for cancer. As part of the scheme, participants such as AstraZeneca, Eli Lilly and Pfizer will contribute raw data from different studies for further analysis.