( CNN ) Oprah 's in there . So 's Bill Murray , George Clooney , Scarlett Johansson , Jerry Seinfeld , Howard Stern , Tina Fey , Michael Keaton and Ray Romano . On Tuesday , `` The Late Show with David Letterman '' announced some of the guests for the talk show host 's final month of broadcasts . The last `` Late Show '' will air Wednesday , May 20 . Among the notables are Oprah Winfrey , with whom Letterman has had an on-and-off faux feud for years ; Clooney , who 's starring in `` Tomorrowland , '' which will be released on May 22 ; and Stern , who 's always an engaging Letterman guest . But longtime fans may be even more intrigued by the appearances of Keaton , an old acquaintance who once shared a stage with Letterman as players on Mary Tyler Moore 's short-lived 1978 variety show , and Murray , who was the very first guest on Letterman 's old NBC show , `` Late Night with David Letterman . '' Steve Martin , who 's taken part in some of the `` Late Show 's '' best bits , will also be dropping by . Letterman has been a late-night host for 33 years , close to 22 of them on CBS ' `` Late Show . '' Stephen Colbert will take over the `` Late Show '' on September 8 .
`` The Late Show with David Letterman '' concludes September 8 . Letterman 's guests will include Oprah Winfrey and Bill Murray . Stephen Colbert takes over the slot May 20 .