Create a hyper-realistic 3D render of a human brain floating in a serene sky, with soft, light clouds in the background. The brain should have intricate neural connections, with neurons and glial cells softly glowing in shades of pink, reddish-orange, and warm yellow. The background should feature a black-to-orange gradient, transitioning smoothly from deep black at the top to warm orange at the bottom, in sync with the brain's glow. Ensure the brain appears slightly illuminated by the natural light, blending gently with the clouds while standing out against the sky. The overall aesthetic should be realistic, calming, and visually striking, highlighting the brain in a tranquil, ethereal environment with the gradient enhancing the visual effect.