diff --git a/dvc/command/plots.py b/dvc/command/plots.py
--- a/dvc/command/plots.py
+++ b/dvc/command/plots.py
@@ -68,8 +68,12 @@ def run(self):
 
             if self.args.open:
                 import webbrowser
+                from platform import uname
 
-                opened = webbrowser.open(index_path)
+                if "Microsoft" in uname().release:
+                    url = Path(rel) / "index.html"
+
+                opened = webbrowser.open(url)
                 if not opened:
                     ui.error_write(
                         "Failed to open. Please try opening it manually."

diff --git a/tests/unit/command/test_plots.py b/tests/unit/command/test_plots.py
--- a/tests/unit/command/test_plots.py
+++ b/tests/unit/command/test_plots.py
@@ -1,5 +1,6 @@
 import os
 import posixpath
+from pathlib import Path
 
 import pytest
 
@@ -149,12 +150,31 @@ def test_plots_diff_open(tmp_dir, dvc, mocker, capsys, plots_data):
     mocker.patch("dvc.command.plots.render", return_value=index_path)
 
     assert cmd.run() == 0
-    mocked_open.assert_called_once_with(index_path)
+    mocked_open.assert_called_once_with(index_path.as_uri())
 
     out, _ = capsys.readouterr()
     assert index_path.as_uri() in out
 
 
+def test_plots_diff_open_WSL(tmp_dir, dvc, mocker, plots_data):
+    mocked_open = mocker.patch("webbrowser.open", return_value=True)
+    mocked_uname_result = mocker.MagicMock()
+    mocked_uname_result.release = "Microsoft"
+    mocker.patch("platform.uname", return_value=mocked_uname_result)
+
+    cli_args = parse_args(
+        ["plots", "diff", "--targets", "plots.csv", "--open"]
+    )
+    cmd = cli_args.func(cli_args)
+    mocker.patch("dvc.repo.plots.diff.diff", return_value=plots_data)
+
+    index_path = tmp_dir / "dvc_plots" / "index.html"
+    mocker.patch("dvc.command.plots.render", return_value=index_path)
+
+    assert cmd.run() == 0
+    mocked_open.assert_called_once_with(Path("dvc_plots") / "index.html")
+
+
 def test_plots_diff_open_failed(tmp_dir, dvc, mocker, capsys, plots_data):
     mocked_open = mocker.patch("webbrowser.open", return_value=False)
     cli_args = parse_args(
@@ -167,7 +187,7 @@ def test_plots_diff_open_failed(tmp_dir, dvc, mocker, capsys, plots_data):
 
     assert cmd.run() == 1
     expected_url = tmp_dir / "dvc_plots" / "index.html"
-    mocked_open.assert_called_once_with(expected_url)
+    mocked_open.assert_called_once_with(expected_url.as_uri())
 
     error_message = "Failed to open. Please try opening it manually."
 

plots --open: not working on macOS
We use relpath to open files in the browser.

https://github.com/iterative/dvc/blob/59cfc2c4a43e9b9d2fdb583da80d24e82ae39c26/dvc/command/plots.py#L60

This is mostly done to support `wsl`, and the fact that all other Platform seem to work, if it's relative or absolute.

The reason why it does not work is because `web browser.open` messes up. 🤦🏼 
https://github.com/python/cpython/blob/39dd141a4ba68bbb38fd00a65cdcff711acdafb5/Lib/webbrowser.py#L638-L639
plots --open: not working on macOS
We use relpath to open files in the browser.

https://github.com/iterative/dvc/blob/59cfc2c4a43e9b9d2fdb583da80d24e82ae39c26/dvc/command/plots.py#L60

This is mostly done to support `wsl`, and the fact that all other Platform seem to work, if it's relative or absolute.

The reason why it does not work is because `web browser.open` messes up. 🤦🏼 
https://github.com/python/cpython/blob/39dd141a4ba68bbb38fd00a65cdcff711acdafb5/Lib/webbrowser.py#L638-L639

tests/unit/command/test_plots.py::test_plots_diff_open_WSL tests/unit/command/test_plots.py::test_plots_diff_open_failed tests/unit/command/test_plots.py::test_plots_diff_open
tests/unit/command/test_plots.py::test_plots_path_is_quoted_and_resolved_properly[quote] tests/unit/command/test_plots.py::test_plots_show_vega tests/unit/command/test_plots.py::test_should_call_render[some_out] tests/unit/command/test_plots.py::test_should_call_render[to/subdir] tests/unit/command/test_plots.py::test_plots_diff tests/unit/command/test_plots.py::test_plots_path_is_quoted_and_resolved_properly[resolve] tests/unit/command/test_plots.py::test_plots_diff_vega tests/unit/command/test_plots.py::test_should_call_render[None]