All three of these peoples, as well as other indigenous peoples of the Pacific Northwest Coast, experienced smallpox outbreaks from the late 18th through the mid-19th century, with the most devastating epidemics occurring in the 1830s and 1860s, resulting in high fatalities and social disruption.
ˈɔːl θɹˈiː ʌv ðiːz pˈiːpəlz, æz wˈɛl æz ˈʌðɚɹ ɪndˈɪdʒənəs pˈiːpəlz ʌvðə pɐsˈɪfɪk nɔːɹθwˈɛst kˈoʊst, ɛkspˈiəɹɪənst smˈɔːlpɑːks ˈaʊtbɹeɪks fɹʌmðə lˈeɪt ˈeɪtiːnθ θɹuː ðə mˈɪd nˈaɪntiːnθ sˈɛntʃɚɹi, wɪððə mˈoʊst dˈɛvᵻstˌeɪɾɪŋ ˌɛpɪdˈɛmɪks əkˈɜːɹɪŋ ɪnðə wˈʌn θˈaʊzənd ˈeɪthˈʌndɹɪd θˈɜːɾi z ænd wˈʌn θˈaʊzənd ˈeɪthˈʌndɹɪd sˈɪksti z, ɹɪzˈʌltɪŋ ɪn hˈaɪ feɪtˈælᵻɾiz ænd sˈoʊʃəl dɪsɹˈʌpʃən.