The most important difference is that once a film is in the production phase, the marginal cost of one more shot is higher for animated films than live-action films.
ðə mˈoʊst ɪmpˈoːɹtənt dˈɪfɹəns ɪz ðæt wˈʌns ɐ fˈɪlm ɪz ɪnðə pɹədˈʌkʃən fˈeɪz, ðə mˈɑːɹdʒɪnəl kˈɔst ʌv wˈʌn mˈoːɹ ʃˈɑːt ɪz hˈaɪɚ fɔːɹ ˈænɪmˌeɪɾᵻd fˈɪlmz ðɐn lˈaɪvˈækʃən fˈɪlmz.