Acids that lose a proton at the intracellular pH will exist in their soluble, charged form and are thus able to diffuse through the cytosol to their target.
ˈæsɪdz ðæt lˈuːz ɐ pɹˈoʊtɑːn æt ðɪ ˌɪntɹəsˈɛljʊlɚ pˈiː ˈeɪtʃ wɪl ɛɡzˈɪst ɪn ðɛɹ sˈɑːljuːbəl, tʃˈɑːɹdʒd fˈɔːɹm ænd ɑːɹ ðˈʌs ˈeɪbəl tə dᵻfjˈuːz θɹuː ðə sˈaɪɾəsˌɑːl tə ðɛɹ tˈɑːɹɡɪt.