One goal of alchemy, the transmutation of base substances into gold, is now known to be impossible by chemical means but possible by physical means.
wˈʌn ɡˈoʊl ʌv ˈælkəmi, ðə tɹænsmjuːtˈeɪʃən ʌv bˈeɪs sˈʌbstənsᵻz ˌɪntʊ ɡˈoʊld, ɪz nˈaʊ nˈoʊn təbi ɪmpˈɑːsᵻbəl baɪ kˈɛmɪkəl mˈiːnz bˌʌt pˈɑːsᵻbəl baɪ fˈɪzɪkəl mˈiːnz.