The difficulty of this task arises from the fact that different definitions of what a domain is can be used (e.g. folding autonomy, function, thermodynamic stability, or domain motions), which sometimes results in a single protein having different—yet equally valid—domain assignments.
ðə dˈɪfɪkˌʌlti ʌv ðɪs tˈæsk ɚɹˈaɪzᵻz fɹʌmðə fˈækt ðæt dˈɪfɹənt dˌɛfɪnˈɪʃənz ʌv wʌt ɐ dəmˈeɪn ɪz kæn biː jˈuːzd ˈiː.dʒˈiː. fˈoʊldɪŋ ɔːtˈɑːnəmi, fˈʌŋkʃən, θˌɜːmoʊdaɪnˈæmɪk stəbˈɪlᵻɾi, ɔːɹ dəmˈeɪn mˈoʊʃənz, wˌɪtʃ sˈʌmtaɪmz ɹɪzˈʌlts ɪn ɐ sˈɪŋɡəl pɹˈoʊtiːn hˌævɪŋ dˈɪfɹənt—jˈɛt ˈiːkwəli vˈælɪd—dəmˈeɪn ɐsˈaɪnmənts.