One notable difference is that Dungeon Runners was rendered using polygonal models, rather than the sprite-based isometric graphics of the Diablo series.
wˈʌn nˈoʊɾəbəl dˈɪfɹəns ɪz ðæt dˈʌndʒən ɹˈʌnɚz wʌz ɹˈɛndɚd jˈuːzɪŋ pˌɑːlˈɪɡənəl mˈɑːdəlz, ɹˈæðɚ ðɐn ðə spɹˈaɪtbˈeɪst ˌaɪsoʊmˈɛtɹɪk ɡɹˈæfɪks ʌvðə diːˈɑːbloʊ sˈɪɹiz.