Additionally, TrkB has been shown to reduce amyloid-β production by APP binding and phosphorylation, while TrkB cleavage by δ-secretase blocks normal TrkB activity.
ɐdˈɪʃənəli, tˌiːˌɑːɹkˈeɪ bˈiː hˈæzbiːn ʃˈoʊn tə ɹᵻdˈuːs ˈæmɪlˌɔɪdbˈeɪɾə pɹədˈʌkʃən baɪ ˌeɪpˌiːpˈiː bˈaɪndɪŋ ænd fˌɑːsfoːɹɪlˈeɪʃən, wˌaɪl tˌiːˌɑːɹkˈeɪ bˈiː klˈiːvɪdʒ baɪ dˈɛltəsˈɛkɹɪtˌeɪs blˈɑːks nˈoːɹməl tˌiːˌɑːɹkˈeɪ bˈiː æktˈɪvᵻɾi.