Binding assays with NS1 protein mutants established that the RNA-binding domain of the NS1 protein is required for binding to dsRNA as well as for binding to polyA and U6 snRNA.
bˈaɪndɪŋ ɐsˈeɪz wɪð ˌɛnˈɛs wˈʌn pɹˈoʊtiːn mjˈuːtənts ɪstˈæblɪʃt ðætðɪ ˌɑːɹɹˌɛnˈeɪbˈaɪndɪŋ dəmˈeɪn ʌvðɪ ˌɛnˈɛs wˈʌn pɹˈoʊtiːn ɪz ɹᵻkwˈaɪɚd fɔːɹ bˈaɪndɪŋ tə dˌiːˈɛs ˌɑːɹɹˌɛnˈeɪ æz wˈɛl æz fɔːɹ bˈaɪndɪŋ tə pˈɑːli ɐ ænd jˈuː sˈɪks ˌɛsˈɛn ˌɑːɹɹˌɛnˈeɪ.