He has developed software for protein modelling and understanding the effects of mutations on protein function, leading to new approaches to structure-guided and Fragment-based lead discovery.
hiː hɐz dɪvˈɛləpt sˈɔftwɛɹ fɔːɹ pɹˈoʊtiːn mˈɑːdəlɪŋ ænd ˌʌndɚstˈændɪŋ ðɪ ɪfˈɛkts ʌv mjuːtˈeɪʃənz ˌɔn pɹˈoʊtiːn fˈʌŋkʃən, lˈiːdɪŋ tə nˈuː ɐpɹˈoʊtʃᵻz tə stɹˈʌktʃɚɡˈaɪdᵻd ænd fɹˈæɡməntbˈeɪst lˈiːd dɪskˈʌvɚɹi.