In type 1 diabetes mellitus, there is direct damage to the endocrine pancreas that results in insufficient insulin synthesis and secretion.
ɪn tˈaɪp wˈʌn dˌaɪəbˈiːɾiːz mˈɛlɪɾəs, ðɛɹ ɪz dᵻɹˈɛkt dˈæmɪdʒ tə ðɪ ˈɛndoʊkɹˌaɪn pˈæŋkɹiəs ðæt ɹɪzˈʌlts ɪn ɪnsəfˈɪʃənt ˈɪnsəlˌɪn sˈɪnθəsˌɪs ænd sᵻkɹˈiːʃən.