Type 2 diabetes mellitus, which begins with insulin resistance, is characterized by the ultimate failure of pancreatic β cells to match insulin production with insulin demand.
tˈaɪp tˈuː dˌaɪəbˈiːɾiːz mˈɛlɪɾəs, wˌɪtʃ bɪɡˈɪnz wɪð ˈɪnsəlˌɪn ɹᵻsˈɪstəns, ɪz kˈæɹɪktɚɹˌaɪzd baɪ ðɪ ˈʌltᵻmət fˈeɪlɪɹ ʌv pˌæŋkɹiːˈæɾɪk bˈeɪɾə sˈɛlz tə mˈætʃ ˈɪnsəlˌɪn pɹədˈʌkʃən wɪð ˈɪnsəlˌɪn dᵻmˈænd.