In the absence of NS1, this pathway is inhibited during anti-viral response to halt all protein translation – thus stopping the synthesis of viral proteins; however, the influenza virus' NS1 protein is an agent that circumvents host defenses to allows viral gene transcription to occur.
ɪnðɪ ˈæbsəns ʌv ˌɛnˈɛs wˈʌn, ðɪs pˈæθweɪ ɪz ɪnhˈɪbɪɾᵻd dˈʊɹɹɪŋ ˈæntaɪvˈaɪɚɹəl ɹᵻspˈɑːns tə hˈɔlt ˈɔːl pɹˈoʊtiːn tɹænslˈeɪʃən ðˈʌs stˈɑːpɪŋ ðə sˈɪnθəsˌɪs ʌv vˈaɪɚɹəl pɹˈoʊtiːnz; haʊˈɛvɚ, ðɪ ˌɪnfluːˈɛnzə vˈaɪɹəs ˌɛnˈɛs wˈʌn pɹˈoʊtiːn ɪz ɐn ˈeɪdʒənt ðæt sˈɜːkəmvˌɛnts hˈoʊst dᵻfˈɛnsᵻz tʊ ɐlˈaʊz vˈaɪɚɹəl dʒˈiːn tɹænskɹˈɪpʃən tʊ əkˈɜː.