At the time of the 2017 census, Tando Muahmmad Khan district had a population of 677,098, of which 349,122 were males and 327,888 females.
æt ðə tˈaɪm ʌvðə tˈuː θˈaʊzənd sˈɛvəntˌiːn sˈɛnsəs, tˈændoʊ mjˈuːɑːmˌæd kˈɑːn dˈɪstɹɪkt hæd ɐ pˌɑːpjʊlˈeɪʃən ʌv sˈɪkshˈʌndɹɪd sˈɛvənti sˈɛvən,zˈiəɹoʊ nˈaɪnti ˈeɪt, ʌvwˈɪtʃ θɹˈiːhˈʌndɹɪd fˈoːɹɾi nˈaɪn,wˈʌnhˈʌndɹɪd twˈɛnti tˈuː wɜː mˈeɪlz ænd θɹˈiːhˈʌndɹɪd twˈɛnti sˈɛvən,ˈeɪthˈʌndɹɪd ˈeɪɾi ˈeɪt fˈiːmeɪlz.