Anecdotal reports state that lopinavir cannot be detected in the CSF; however, a study of paired CSF-plasma samples from 26 patients receiving lopinavir/ritonavir found lopinavir CSF levels above the IC50 in 77% of samples.
ˈænɪkdˌoʊɾəl ɹᵻpˈoːɹts stˈeɪt ðæt lˈɑːpɪnˌævɪɹ kænˈɑːt biː dɪtˈɛktᵻd ɪnðə sˌiːˌɛsˈɛf; haʊˈɛvɚ, ɐ stˈʌdi ʌv pˈɛɹd sˌiːˌɛsˈɛfplˈæzmə sˈæmpəlz fɹʌm twˈɛnti sˈɪks pˈeɪʃənts ɹᵻsˈiːvɪŋ lˈɑːpɪnˌævɪɹ slˈæʃ ɹˈɪtənˌævɪɹ fˈaʊnd lˈɑːpɪnˌævɪɹ sˌiːˌɛsˈɛf lˈɛvəlz əbˌʌv ðɪ ˌaɪsˈiː fˈɪfti ɪn sˈɛvənti sˈɛvən pɚsˈɛnt ʌv sˈæmpəlz.