ðə mˈɛkənˌɪzəm ʌv ˌæktɪvˈeɪʃən ʌvðə hjˈuːmən tˌiːˌɑːɹkˈeɪ ˈɑːŋkoʊdʒˌiːn ɪz səspˈɛktᵻd tʊ ɪnvˈɑːlv ɐ fˈoʊldɪŋ ʌv ɪts kˈɪneɪs dəmˈeɪn, lˈiːdɪŋ ðə ɹᵻsˈɛptɚ tə ɹᵻmˈeɪn kˈɑːnstɪtˌuːɾɪvli ˈæktɪv.
The mechanism of activation of the Human Trk oncogene is suspected to involve a folding of its kinase domain, leading the receptor to remain constitutively active.