ðə hˈɑːspɪɾəl wʌz fˈaʊndᵻd ɪn nˈaɪntiːnhˈʌndɹɪd æz ðə saʊθˈæmptən jˈuːniən ɪnfˈɜːmɚɹi ɪn ʃˈɜːli wˈɔːɹən, saʊθˈæmptən, tə ɹᵻplˈeɪs hˈɑːspɪɾəl bˈɛdz pɹˈiːviəsli pɹəvˈaɪdᵻd æt ðə wˈɜːkhaʊs ɪnfˈɜːmɚɹi ɪn sənt mˈɛɹiz, saʊθˈæmptən.
The hospital was founded in 1900 as the Southampton Union Infirmary in Shirley Warren, Southampton, to replace hospital beds previously provided at the workhouse infirmary in St Mary's, Southampton.