ɐ sɪstˈɛmɪk dɪzˈiːz ɪz wˈʌn ðæt ɐfˈɛkts ɐ nˈʌmbɚɹ ʌv ˈɔːɹɡənz ænd tˈɪʃuːz, ɔːɹ ɐfˈɛkts ðə bˈɑːdi æz ɐ hˈoʊl.
A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole.