baɪ ðæt tˈaɪm, ðɪ ˈɜːlɪɚɹ ɪndˈɪdʒənəs tɹˈaɪbz ʌv ðæt ˈɛɹiə ɐpˈæɹəntli wɜː nˌoʊ lˈɑːŋɡɚ pɹˈɛzənt, dˈuː pɹɪzˈuːməbli tə ðɛɹ lˈæk ʌv ɹᵻsˈɪstəns tə jˌʊɹɹəpˈiən dɪzˈiːzᵻz sˈʌtʃ ɐz mˈiːzəlz ænd smˈɔːlpɑːks ðæt hɐdbɪn kˈæɹid ɪn ˈɜːlɪɚ baɪ jˌʊɹɹəpˈiən tɹˈæfɪk ɐlˈɔŋ ðə mˌɪsɪsˈɪpi ɹˈɪvɚ.
By that time, the earlier indigenous tribes of that area apparently were no longer present, due presumably to their lack of resistance to European diseases such as measles and smallpox that had been carried in earlier by European traffic along the Mississippi River.