ɪn nˈaɪntiːnhˈʌndɹɪd nˈaɪnti tˈuː, dʒˈæk bˈɔːldwɪn, ɹˈɑːbɚt ˈædlɪŋtən, dˈeɪvɪd bˈɛbɪŋtən, ænd ˈændɹuː ɹˈʌsəl ɐkˈɑːmplɪʃt ðə fˈɜːst ˌeɪsɪmˈɛtɹɪk tˈoʊɾəl sˈɪnθəsˌɪs ʌvðɪ ˌɪndᵻvˈɪdʒuːəl dˈaɪəstˌɛɹɪˌoʊɪsəmɚz ʌv hˌaɪpoʊɡlˈaɪsɪn ˈeɪ, jˈuːzɪŋ ðə ʃˈɑːɹpləs ɪpˌɑːksɪdˈeɪʃən tə pɚmˈɪt ɐn ˌeɪsɪmˈɛtɹɪk mˈɛθɪlˌiːn sˌaɪkləpɹˈoʊpeɪn sˈɪnθəsˌɪs.
In 1992, Jack Baldwin, Robert Adlington, David Bebbington, and Andrew Russell accomplished the first asymmetric total synthesis of the individual diastereoisomers of hypoglycin A, using the Sharpless epoxidation to permit an asymmetric methylene cyclopropane synthesis.