ɪt hɐz ˈɔːlsoʊ bˌɪn ʃˈoʊn, haʊˈɛvɚ, ðæt ɪnðɪ ˈæbsəns əvə kˈoʊɛkspɹˈɛst tˌiːˌɑːɹkˈeɪ ˈeɪ, ðɪ ˌɛlˌɛndʒˈiːˌɛfˈɑːɹ mˈeɪ sˈɪɡnəl ɐ sˈɛl tə dˈaɪ vˈaɪəɹ ɐpəptˈoʊsɪs sˌoʊ ðˈɛɹfoːɹ sˈɛlz ɛkspɹˈɛsɪŋ ðɪ ˌɛlˌɛndʒˈiːˌɛfˈɑːɹ ɪnðɪ ˈæbsəns ʌv tˌiːˌɑːɹkˈeɪ ɹᵻsˈɛptɚz mˈeɪ dˈaɪ ɹˈæðɚ ðɐn lˈɪv ɪn ðə pɹˈɛzəns əvə nˌʊɹɹətɹˈoʊfɪn.
It has also been shown, however, that in the absence of a co-expressed TrkA, the LNGFR may signal a cell to die via apoptosis – so therefore cells expressing the LNGFR in the absence of Trk receptors may die rather than live in the presence of a neurotrophin.