ɐ sˈɛkənd ɹˈaʊnd ʌv ˌɛldˌiːˈeɪ ðˈɛn dʒˈɛnɚɹˌeɪts ɐ kɑːɹbˈæniən æt ðɪ ˈoʊnli ˈoʊpən pəzˈɪʃən; ɹɪˈækʃən wɪð mˈɛθəl ˈaɪədˌaɪd lˈiːdz tə ðə kˌɔːɹɪspˈɑːndɪŋ fˈaɪv mˈɛθəl dᵻɹˈɪvətˌɪv fˈaɪv.
A second round of LDA then generates a carbanion at the only open position; reaction with methyl iodide leads to the corresponding 5 methyl derivative (5).