ˈænɪkdˌoʊɾəl ɹᵻpˈoːɹts stˈeɪt ðæt lˈɑːpɪnˌævɪɹ kænˈɑːt biː dɪtˈɛktᵻd ɪnðə sˌiːˌɛsˈɛf; haʊˈɛvɚ, ɐ stˈʌdi ʌv pˈɛɹd sˌiːˌɛsˈɛfplˈæzmə sˈæmpəlz fɹʌm twˈɛnti sˈɪks pˈeɪʃənts ɹᵻsˈiːvɪŋ lˈɑːpɪnˌævɪɹ slˈæʃ ɹˈɪtənˌævɪɹ fˈaʊnd lˈɑːpɪnˌævɪɹ sˌiːˌɛsˈɛf lˈɛvəlz əbˌʌv ðɪ ˌaɪsˈiː fˈɪfti ɪn sˈɛvənti sˈɛvən pɚsˈɛnt ʌv sˈæmpəlz.
Anecdotal reports state that lopinavir cannot be detected in the CSF; however, a study of paired CSF-plasma samples from 26 patients receiving lopinavir/ritonavir found lopinavir CSF levels above the IC50 in 77% of samples.