sˌæntɪˈɑːɡoʊ plˈeɪd ɪn mˈeɪdʒɚ lˈiːɡ bˈeɪsbɔːl ˌɛmˌɛlbˈiː æz ɐn ɪnfˈiːldɚ fɚðə dɪtɹˈɔɪt tˈaɪɡɚz fɹʌm tˈuː θˈaʊzənd tˈuː tə tˈuː θˈaʊzənd θɹˈiː, ðə siːˈæɾəl mˈæɹɪnɚz fɹʌm tˈuː θˈaʊzənd fˈoːɹ tə tˈuː θˈaʊzənd fˈaɪv, ɐɡˈɛn wɪððə tˈaɪɡɚz fɹʌm tˈuː θˈaʊzənd sˈɪks tə tˈuː θˈaʊzənd θˈɜːtiːn ænd wɪððə sˌɪnsɪnˈæɾi ɹˈɛdz ɪn tˈuː θˈaʊzənd fˈoːɹtiːn.
Santiago played in Major League Baseball (MLB) as an infielder for the Detroit Tigers from 2002 to 2003, the Seattle Mariners from 2004 to 2005, again with the Tigers from 2006 to 2013 and with the Cincinnati Reds in 2014.