ɪn wˈʌn stˈʌdi, ɐ tˈoʊɾəl ˈæbsəns ʌv tˌiːˌɑːɹkˈeɪ ɐ ɹᵻsˈɛptɚ wʌz fˈaʊnd ɪn kˈɛɹɐtˌɑːkoʊnəsɐfˈɛktᵻd kˈɔːɹniəz, ɐlˈɔŋ wɪð ɐn ɪŋkɹˈiːst lˈɛvəl ʌv ɹᵻpɹˈɛsɚɹ ˈaɪsəfˌɔːɹm ʌv ˌɛspˈiː θɹˈiː tɹænskɹˈɪpʃən fˈæktɚ.
In one study, a total absence of TrkA receptor was found in keratoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.