ˌɔn sɛptˈɛmbɚ twˈɛnti sˈɛvən, hiː hˈɪt ɐ wˈɔːk ˈɔf ɡɹˈænd slˈæm ɪnðə θˈɜːtiːnθ ˈɪnɪŋ ɐɡˈɛnst pˈɪtsbɜːɡ pˈaɪɹəts pˈɪtʃɚ bˈɑːbi lˌæ fɹˈɑːmbɔɪs ɪn wʌt wʊd biː ðə lˈæst æt bˈæt ʌv sˌæntɪˈɑːɡoʊz mˈeɪdʒɚ lˈiːɡ kɚɹˈɪɹ.
On September 27, he hit a walk–off grand slam in the 13th inning against Pittsburgh Pirates pitcher Bobby LaFromboise in what would be the last at–bat of Santiago's Major League career.