haʊˈɛvɚ, hˌɪstɪdaɪnˈiːmiə ɪz kənsˈɪdɚd ðə mˈoʊst pɹˈɛvələnt ˈɪnbɔːɹn ˈɛɹɚɹ ʌv mətˈæbəlˌɪzəm wɪð ɐ ɹᵻpˈoːɹɾᵻd ˈɪnsɪdəns ʌv wˈʌn:ˈeɪt θˈaʊzənd sˈɪkshˈʌndɹɪd kwᵻbˈɛk; wˈʌn:wˈʌnhˈʌndɹɪd ˈeɪɾi,zˈiəɹoʊzˈiəɹoʊ zˈiəɹoʊ nˈuː jˈɔːɹk ænd wˈʌn:nˈaɪn θˈaʊzənd sˈɪkshˈʌndɹɪd dʒəpˈæn; ænd ɐn ˈævɹɪdʒ ʌv wˈʌn:twˈɛlv,zˈiəɹoʊzˈiəɹoʊ zˈiəɹoʊ əbzˈɜːvd ɪnðə nˈiːoʊnˌeɪɾəl skɹˈiːnɪŋ ʌv ˌoʊvɚ twˈɛnti mˈɪliən nˈuːbɔːɹnz.
However, histidinemia is considered the most prevalent inborn error of metabolism with a reported incidence of 1:8600 (Quebec); 1:180,000 (New York) and 1:9600 (Japan); and an average of 1:12,000 observed in the neonatal screening of over 20 million newborns.