bᵻtwˌiːn ˌeɪˌɛspˈiː ɹˈaʊt θɹˈiː ænd ˈɛɡzɪt ˈeɪtiːn ʌvðə sˈʌðɚn tˈɪɹ ɛkspɹˈɛsweɪ aɪ ˈeɪɾi sˈɪks ænd ˌɛnwˈaɪ sˈɛvəntˌiːn, ˌɛnwˈaɪ tˈuːhˈʌndɹɪd ˈeɪɾi kəntˈɪnjuːz tə stɹˈædəl bˈoʊθ ðɪ ˈiːstɚn ɛkstˈɛnt ʌvðɪ ˈælɪɡhˌɛni ɹˈɛzɚvwˌɑːɹ ænd ðə wˈɛstɚn pɚɹˈɪmɪɾɚɹ ʌv ˈælɪɡəni stˈeɪt pˈɑːɹk bᵻfˌoːɹ tˈɜːmᵻnˌeɪɾɪŋ æɾə dˈaɪəmənd ˌɪntɚtʃˈeɪndʒ wɪððə sˈʌðɚn tˈɪɹ ɛkspɹˈɛsweɪ.
Between ASP Route 3 and exit 18 of the Southern Tier Expressway (I-86 and NY 17), NY 280 continues to straddle both the eastern extent of the Allegheny Reservoir and the western perimeter of Allegany State Park before terminating at a diamond interchange with the Southern Tier Expressway.