kwˈɑːɹlz wʌz bˈɔːɹn nˌɪɹ lˈuːɪsə kˈoːɹt hˈaʊs ɪn lˈuːɪsə kˈaʊnti, vɜːdʒˈɪniə, sˈʌn ʌv ɡˈæɹɪt mˈaɪnɚ ænd mˈɛɹi dʒˈɑːnsən pˈɔɪndɛkstɚ kwˈɑːɹlz.
Quarles was born near Louisa Court House in Louisa County, Virginia, son of Garrett Minor and Mary Johnson Poindexter Quarles.