ɹᵻsˈɜːtʃ hɐz ʃˈoʊn ðæt ˌæktɪvˈeɪʃən ʌvðə tˌiːˌɑːɹkˈeɪ bˈiː ɹᵻsˈɛptɚ kæn lˈiːd tə dˌaʊn ɹˌɛɡjʊlˈeɪʃən ʌvðə kˌeɪsˌiːsˈiː tˈuː klˈoːɹaɪd tɹænspˈoːɹɾɚɹ ɪn sˈɛlz ʌvðə sˌiːˌɛnˈɛs.
Research has shown that activation of the TrkB receptor can lead to down regulation of the KCC2 chloride transporter in cells of the CNS.