lˈeɪɾɚɹ ɪn dɪvˈɛləpmənt dˈʊɹɹɪŋ nˌʊɹɹuːlˈeɪʃən, ɛkstˈɛndᵻd kˈɑːntækt ænd ˌɪntɚɹˈækʃən bᵻtwˌiːn nˈɑːɾəkˌɔːɹd ænd fˈeɪɾᵻd flˈoːɹ plˈeɪt sˈɛlz kˈɔːzᵻz dˌɪfɚɹˌɛnʃɪˈeɪʃən, sədʒˈɛstɪŋ ɐ koʊˈɑːpɚɹətˌɪv ɪfˈɛkt bᵻtwˌiːn nˈoʊdəl ænd ˌɛsˌeɪtʃˈeɪtʃ sˈɪɡnəlɪŋ.
Later in development during neurulation, extended contact and interaction between notochord and fated floor plate cells causes differentiation, suggesting a cooperative effect between Nodal and Shh signaling.