ðɪs kˈɪneɪs fˈɑːsfoːɹˌɪleɪts ðɪ ˈælfə sˈʌbjuːnˌɪt ʌv jˌuːkɐɹɪˈɑːɾɪk tɹænslˈeɪʃən ɪnˌɪʃɪˈeɪʃən fˈæktɚ tˈuː ˌɛl ˈɛf tˈuː ˈælfə, lˈiːdɪŋ tʊ ɐ dˈiːkɹiːs ɪnðə ɹˈeɪt ʌv ɪnˌɪʃɪˈeɪʃən ʌv tɹænslˈeɪʃən.
This kinase phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (elF-2 alpha), leading to a decrease in the rate of initiation of translation.