pˈɑːsɐkˌɑːnɐzˌoʊl wˈɜːks baɪ dɪsɹˈʌptɪŋ ðə klˈoʊs pˈækɪŋ ʌv ɐkˈɪl tʃˈeɪnz ʌv fˈɑːsfəlˌɪpɪdz, ɪmpˈɛɹɪŋ ðə fˈʌŋkʃənz ʌv sˈɜːʔn̩ mˈɛmbɹeɪnbˈaʊnd ˈɛnzaɪm sˈɪstəmz sˈʌtʃ ɐz æt pˈeɪs ænd ˈɛnzaɪmz ʌvðɪ ᵻlˈɛktɹɑːn tɹˈænspoːɹt sˈɪstəm, ðˈʌs ɪnhˈɪbɪɾɪŋ ɡɹˈoʊθ ʌvðə fˈʌŋɡi.
Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the electron transport system, thus inhibiting growth of the fungi.