mæŋkjˈuːsoʊ ɪz ɐn ɪtˈæliən sˈɜːneɪm dᵻɹˈaɪvd fɹʌm ɐ sɪsˈɪliən nˈaʊn, ɹᵻlˈeɪɾᵻd tə ðɪ ɪtˈæliən mænsˈiːnoʊ, wˌɪtʃ mˈiːnz "lˈɛfthˈændᵻd".
Mancuso is an Italian surname derived from a Sicilian noun, related to the Italian mancino, which means "left-handed".