mænwˈɛl wʌz bᵻtɹˈoʊðd tʊ ˌɪseɪbˈɛl ɔːɹ zˈæmpiəmɚɹˈiːə də lˈuːsɪɡnən kˈɑː ɔːɹ ˈæftɚ wˈʌn θˈaʊzənd θɹˈiːhˈʌndɹɪd θˈɜːɾi θɹˈiː ɪn sˈaɪpɹəs, wˈʌn θˈaʊzənd θɹˈiːhˈʌndɹɪd ˈeɪɾi tˈuː wˈʌn θˈaʊzənd θɹˈiːhˈʌndɹɪd ˈeɪɾi sˈɛvən, ɐ dˈɔːɾɚɹ ʌv ɡˈaɪ ʌv lˈuːsɪɡnən kˈɪŋ kˈɑːnstɐntˌiːn ɹˌoʊmən tˈuː ɔːɹ ɹˌoʊmən fˈoːɹ ʌvðɪ ɑːɹmˈiːniən kˈɪŋdəm ʌv sɪlˈɪʃə sˌʌm tˈaɪm bᵻfˌoːɹ wˈʌn θˈaʊzənd θɹˈiːhˈʌndɹɪd fˈoːɹɾi wˈʌn, wˌaɪl ˈɛmpɚɹɚɹ ˌændɹənˈɪkoʊz ɹˌoʊmən θɹˈiː pˌæleɪəlˈoʊɡoʊz wʌz stˈɪl ɐlˈaɪv.
Manuel was betrothed to Isabelle (or Zampea-Maria) de Lusignan (ca or after 1333 – in Cyprus, 1382–1387), a daughter of Guy of Lusignan (King Constantine II or IV of the Armenian Kingdom of Cilicia) some time before 1341, while Emperor Andronikos III Palaiologos was still alive.