ɐ mjuːtˈeɪʃən ˌɔn wˈʌn kˈɑːpi ʌvðə dʒˈiːn kˈɔːzᵻz ˈoʊnli hˈæf ʌv ðɪs nˈɛsᵻsɚɹi pɹˈoʊtiːn təbi mˌeɪd ænd ðə sˈɛlz ʌvðə skˈɪn duːnˌɑːt ɐdhˈɪɹ təɡˌɛðɚ pɹˈɑːpɚli dˈuː tə mˌælfɔːɹmˈeɪʃən ʌv ˌɪntɚsˈɛljʊlɚ dˈɛzməsˌoʊmz, kˈɔːzɪŋ ɐkɐnθˈɑːləsˌɪs, blˈɪstɚz ænd ɹˈæʃᵻz.
A mutation on one copy of the gene causes only half of this necessary protein to be made and the cells of the skin do not adhere together properly due to malformation of intercellular desmosomes, causing acantholysis, blisters and rashes.