ɪn skˈɑːtzvɪl, ˌɛnwˈaɪ tˈuːhˈʌndɹɪd fˈɪfti θɹˈiː wʌz kəŋkˈɜːɹənt wɪð ˌɛnwˈaɪ θˈɜːɾi fˈaɪv, ɐ ɹˈaʊt stɹˈɛtʃɪŋ fɹʌm bˈʌfəlˌoʊ tʊ ɑːntˈæɹɪˌoʊ vˈaɪə kˈænɐwˌɔːɡəs wˈɛst ʌv ˈeɪvɑːn, ɹˈɑːtʃɛstɚ, ænd wˈɔlwɜːθ, ˌɔn ɹˈɑːtʃɛstɚ stɹˈiːt.
In Scottsville, NY 253 was concurrent with NY 35, a route stretching from Buffalo to Ontario via Canawaugus (west of Avon), Rochester, and Walworth, on Rochester Street.