sˈɪns ˌɛsˌeɪtʃˈeɪtʃ ɹˈɛɡjʊlˌeɪts ɡlˈaɪ pɹˈɑːsɛsɪŋ, ɪf smˈoʊ ɪz kˈɑːmpɹəmˌaɪzd ɔːɹ ɪnhˈɪbɪɾᵻd baɪ pˌiːtˌiːsˌiːˈeɪtʃ wˈʌn, ðɪs ɪnˈæktᵻvˌeɪts ðɪ ˌɛsˌeɪtʃˈeɪtʃ pˈæθweɪ ænd pɹɪvˈɛnts ɡlˈaɪ pɹˈɑːsɛsɪŋ wˌɪtʃ dɪsɹˈʌpts ɡlˈaɪəl sˈɛl fˈeɪt mˈæpɪŋ.
Since Shh regulates Gli processing, if Smo is compromised or inhibited by Ptch1, this inactivates the Shh pathway and prevents Gli processing which disrupts glial cell fate mapping.