dʒˈɑːn ˈɛf. kˈɛnədi kˈæmpəs ɪz loʊkˈeɪɾᵻd ɐlˈɔŋ ðə nˈɔːɹθ sˈaʊθ bˈoːɹdɚɹ ʌvðə bɹˈɑːŋks ænd mænhˈæʔn̩, ðɪ ˈiːstɚn hˈæf ʌvðə kˈæmpəs wɪðˌɪn mˈɑːɹbəl hˈɪl, ænd ðə wˈɛstɚn hˈæf ɪn spˈaɪʔn̩ dˈaɪvəl, wɪððə hˈʌdsən lˈaɪn ʌvðə mˈɛtɹoʊnˈɔːɹθ ɹˈeɪlɹoʊd ænd spˈaɪʔn̩ dˈaɪvəl kɹˈiːk tə ðə sˈaʊθ.
John F. Kennedy Campus is located along the north–south border of the Bronx and Manhattan, the eastern half of the campus within Marble Hill, and the western half in Spuyten Duyvil, with the Hudson Line of the Metro-North Railroad and Spuyten Duyvil Creek to the south.