ɡɹˈɛpɐflˌɑːksɐsˌɪn wʌz jˈuːzd fɔːɹ tɹˈiːɾɪŋ ɛɡzˌæsɚbˈeɪʃənz ʌv kɹˈɑːnɪk bɹəŋkˈaɪɾɪs kˈɔːzd baɪ səsˈɛptᵻbəl bæktˈɪɹiə ˈiː.dʒˈiː. hˈiːməfˌɪləs ˈɪnfluːənzˌiː, stɹˈɛptəkˌɑːkəs nuːmˈoʊnɪˌiː, mˌɔːɹɐksˈɛlə kˌæɾɐɹˈɑːliz, kəmjˈuːnᵻɾiɐkwˈaɪɚd nuːmˈoʊniə ɪŋklˈuːdɪŋ ðˈoʊz, ɪn ɐdˈɪʃən tə ðɪ əbˌʌv dʒˈɜːmz, kˈɔːzd baɪ mˈaɪkəplˌæzmə nuːmˈoʊnɪˌiː ɡˈɑːnɔɹˌiə ænd nˈɑːŋɡˈɑːnəkˌɑːkəl jˌʊɹɹɪθɹˈaɪɾɪs ænd sˌɜːvɪsˈaɪɾɪs fɔːɹ ɛɡzˈæmpəl kˈɔːzd baɪ klæmˈɪdiə tɹˌækəmˈɑːɾiz ɔːɹ jˈʊɹɹiːplˌæzmə jˈʊɹɹiːlˌɪɾɪkəm.
Grepafloxacin was used  for treating exacerbations of chronic bronchitis caused by susceptible bacteria (e.g. Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis), community-acquired pneumonia (including those, in addition to the above germs, caused by Mycoplasma pneumoniae) gonorrhea and non-gonococcal urethritis and cervicitis (for example caused by Chlamydia trachomatis or Ureaplasma urealyticum).