mˈɛni kjˈʊɹɹeɪɾᵻd dˈeɪɾəbˌeɪsᵻz hˈæzbiːn ɪstˈæblɪʃt tə dˈɑːkjuːmənt ðɪ ˈɪmpækt ʌv klˈɪnɪkli sɪɡnˈɪfɪkənt sˈiːkwəns vˌɛɹɪˈeɪʃənz, sˈʌtʃ ɐz dˌiːbˈiː ˌɛsˌɛnpˈiː ɔːɹ klˈɪn vˈɑːɹ.
Many curated databases has been established to document the impact of clinically significant sequence variations, such as dbSNP  or ClinVar.