ðə bˈaɪndɪŋ ʌv ˌɛndʒˌiːˈɛf tə tˌiːˌɑːɹkˈeɪ ɐ lˈiːdz tʊ ɐ lˈɪɡændɪndˈuːst dˌaɪmɹᵻzˈeɪʃən, ænd ɐ pɹəpˈoʊzd mˈɛkənˌɪzəm baɪ wˌɪtʃ ðɪs ɹᵻsˈɛptɚ ænd lˈɪɡænd ˌɪntɚɹˈækt ɪz ðæt tˈuː tˌiːˌɑːɹkˈeɪ ɐ ɹᵻsˈɛptɚz ɐsˈoʊsɪˌeɪt wɪð ɐ sˈɪŋɡəl ˌɛndʒˌiːˈɛf lˈɪɡænd.
The binding of NGF to TrkA leads to a ligand-induced dimerization, and a proposed mechanism by which this receptor and ligand interact is that two TrkA receptors associate with a single NGF ligand.