æt ðə sˈɛljʊlɚ lˈɛvəl, sənt ˌeɪˈɑːɹ ɪz sˈɪnθəsˌaɪzd tˈɪpɪkli ɪn ɹᵻspˈɑːns tʊ ˌæktɪvˈeɪʃən ʌvðə sˈiː ˌeɪˌɛmpˈiː sˈɛkənd mˈɛsɪndʒɚ sˈɪstəm, ɔːlðˈoʊ ˈʌðɚ sˈɪstəmz kæn biː ɪnvˈɑːlvd ˈiːvən ˌɪndᵻpˈɛndəntli ʌv sˈiː ˌeɪˌɛmpˈiː.
At the cellular level, StAR is synthesized typically in response to activation of the cAMP second messenger system, although other systems can be involved even independently of cAMP.