ˌɛlˌoʊˈeɪtʃ əkˈɜːz wɛn wˈʌn ɐlˈiːl əvə dʒˈiːn ɪz mjuːtˈeɪɾᵻd ɪn ɐ dᵻlɪtˈɪɹiəs wˈeɪ ænd ðə nˈoːɹməlifˈʌŋkʃənɪŋ ɐlˈiːl ɪz lˈɔst.
LOH occurs when one allele of a gene is mutated in a deleterious way and the normally-functioning allele is lost.