ˈæftɚɹ ˌɪndᵻpˈɛndəns, ðə ɹᵻlˈɪdʒən wʌz ˌɪntɹədˈuːst baɪ ˈɪmɪɡɹənts fɹʌmðə nˈeɪbɚɹɪŋ kˈʌntɹiz ʌv naɪdʒˈiəɹɪə ænd kˌæmɚɹˈuːn, wˌɪtʃ lˈɛd tʊ ɐ ɹˈaɪz ɪnðə nˈʌmbɚɹ ʌv mˈʊzlɪmz ɪn sˈaʊ təmˈeɪ ænd pɹˈɪnsaɪp, fɹʌm zˈiəɹoʊ ɪn nˈaɪntiːnhˈʌndɹɪd sˈɛvənti tə fˈɪfti wˈʌn ɪn nˈaɪntiːnhˈʌndɹɪd nˈaɪnti fˈoːɹ ænd sˈɪksti fˈoːɹ ɪn tˈuː θˈaʊzənd nˈaɪn.
After independence, the religion was introduced by immigrants from the neighbouring countries of Nigeria and Cameroon, which led to a rise in the number of Muslims in São Tomé and Príncipe, from zero in 1970 to 51 in 1994 and 64 in 2009.