mˈoʊst stˈætɪnz ɑːɹ mətˈæbəlˌaɪzd ɪn pˈɑːɹt baɪ wˈʌn ɔːɹ mˈoːɹ hɛpˈæɾɪk sˈaɪɾəkɹˌoʊm pˈiː fˈoːɹhˈʌndɹɪd fˈɪfti ˈɛnzaɪmz, lˈiːdɪŋ tʊ ɐn ɪŋkɹˈiːst pətˈɛnʃəl fɔːɹ dɹˈʌɡ ˌɪntɚɹˈækʃənz ænd pɹˈɑːbləmz wɪð sˈɜːʔn̩ fˈuːdz sˈʌtʃ ɐz ɡɹˈeɪpfɹuːt dʒˈuːs.
Most statins are metabolised in part by one or more hepatic cytochrome P450 enzymes, leading to an increased potential for drug interactions and problems with certain foods (such as grapefruit juice).