tˌiːˌɑːɹkˈeɪ bˈiː ænd ɪts lˈɪɡænd bˌiːdˌiːˌɛnˈɛf hɐvbɪn ɐsˈoʊsɪˌeɪɾᵻd tə bˈoʊθ nˈoːɹməl bɹˈeɪn fˈʌŋkʃən ænd ɪnðə pæθˈɑːlədʒi ænd pɹəɡɹˈɛʃən ʌv ˈɑːltshaɪmɚz dɪzˈiːz ˌeɪdˈiː ænd ˈʌðɚ nˈʊɹɹoʊddʒˌɛnɚɹətˌɪv dɪsˈoːɹdɚz.
TrkB and its ligand BDNF have been associated to both normal brain function and in the pathology and progression of Alzheimer’s disease (AD) and other neurodegenerative disorders.