ðə dɪsˈoːɹdɚɹ ɪz kˈɔːzd baɪ ɐ mjuːtˈeɪʃən ɪnðɪ ɐkˈædsb dʒˈiːn, loʊkˈeɪɾᵻd ɔnðə lˈɔŋ ˈɑːɹm ʌv hjˈuːmən kɹˈoʊməsˌoʊm tˈɛn tˈɛn kjˈuː twˈɛnti fˈaɪvkjˈuː twˈɛnti sˈɪks.
The disorder is caused by a mutation in the ACADSB gene, located on the long arm of human chromosome 10 (10q25-q26).