ˌɛsˈeɪtʃ sˈɛvənti tˈuː bɪɡˈɪnz ɪn fˈɑːɹ wˈɛstɚn mək mˈʌlən kˈaʊnti, nˌɪɹ ðə lˌæ sˈæl kˈaʊnti lˈaɪn, æɾ ɐn ˌɪntɚsˈɛkʃən wɪð ˌɛsˈeɪtʃ nˈaɪnti sˈɛvən nˈɔːɹθ ʌv fˈaʊlɚtən.
SH 72 begins in far western McMullen County, near the La Salle County line, at an intersection with  SH 97 north of Fowlerton.