əpˌɑːn ˌæktɪvˈeɪʃən, ðə tˈaɪɹəsˌaɪn ɹˈɛsɪdˌuːz ɑːɹ fˈɑːsfoːɹˌɪleɪɾᵻd wɪðˌɪn ðə sˌaɪɾəplˈæzmɪk dəmˈeɪn ʌv tˌiːˌɑːɹkˈeɪ ˈeɪ, ænd ðiːz ɹˈɛsɪdˌuːz ðˈɛn ɹᵻkɹˈuːt sˈɪɡnəlɪŋ mˈɑːlɪkjˌuːlz, fˈɑːloʊɪŋ sˈɛvɹəl pˈæθweɪz ðæt lˈiːd tə ðə dˌɪfɚɹˌɛnʃɪˈeɪʃən ænd sɚvˈaɪvəl ʌv nˈʊɹɹɑːnz.
Upon activation, the tyrosine residues are phosphorylated within the cytoplasmic domain of TrkA, and these residues then recruit signaling molecules, following several pathways that lead to the differentiation and survival of neurons.