tˈaɪp tˈuː dˌaɪəbˈiːɾiːz mˈɛlɪɾəs, wˌɪtʃ bɪɡˈɪnz wɪð ˈɪnsəlˌɪn ɹᵻsˈɪstəns, ɪz kˈæɹɪktɚɹˌaɪzd baɪ ðɪ ˈʌltᵻmət fˈeɪlɪɹ ʌv pˌæŋkɹiːˈæɾɪk bˈeɪɾə sˈɛlz tə mˈætʃ ˈɪnsəlˌɪn pɹədˈʌkʃən wɪð ˈɪnsəlˌɪn dᵻmˈænd.
Type 2 diabetes mellitus, which begins with insulin resistance, is characterized by the ultimate failure of pancreatic β cells to match insulin production with insulin demand.