ɪn pˈeɪʃənts wɪð kəndʒˈɛnɪɾəl ɐdɹˈiːnəl hˌaɪpɚplˈæʒə dˈuː tə θɹˈiː bˈeɪɾəhaɪdɹˈɑːksɪstɚɹˌɔɪd dˌiːhaɪdɹˈoʊdʒneɪs dᵻfˈɪʃənsi sˈɛvəntˌiːn ˈælfəhaɪdɹˈɑːksɪpɹˌɛɡnənˌɑːloʊn ɪz ɪŋkɹˈiːst, wˌaɪl ɪn pˈeɪʃənts wɪð kəndʒˈɛnɪɾəl ɐdɹˈiːnəl hˌaɪpɚplˈæʒə dˈuː tə sˈɛvəntˌiːn ˈælfəhaɪdɹˈɑːksɪlˌeɪz dᵻfˈɪʃənsi lˈɛvəlz ɑːɹ lˈoʊ tʊ æbsˈɛnt.
In patients with congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency 17α-hydroxypregnenolone is increased, while in patients with congenital adrenal hyperplasia due to 17α-hydroxylase deficiency levels are low to absent.