ɪnðə mˈoʊst wˈaɪdli ɐksˈɛptᵻd vjˈuː, mˈaɪɾəsˌoʊmz ɑːɹ ˈʌltᵻmətli dᵻɹˈaɪvd fɹʌm mˌaɪɾəkˈɑːndɹiə, ænd kˌɑːmənˈælᵻɾiz bᵻtwˌiːn ðə pɹˈoʊtiːn tɹˈænspoːɹt ænd sˈɪɡnəlɪŋ nˈɛtwɜːks ʌv mˌaɪɾəkˈɑːndɹiə, hˈaɪdɹoʊdʒnˌɑːsoʊmz ɐ ɹᵻlˈeɪɾᵻd klˈæs ʌv ˈɛmɹˈoʊz, ænd mˈaɪɾəsˌoʊmz hɐvbɪn ɪntˈɜːpɹɪɾᵻd æz ɹˈɛlɪks ʌv ðɛɹ kˈɑːmən ˌɛndoʊsˌɪmbaɪˈɑːɾɪk ˈɔːɹɪdʒˌɪn.
In the most widely accepted view, mitosomes are ultimately derived from mitochondria, and commonalities between the protein transport and signaling networks of mitochondria, hydrogenosomes (a related class of MROs), and mitosomes have been interpreted as relics of their common endosymbiotic origin.