æz ðɪ ˈoʊnli ˈɛɹiə ʌvðə sˈɪɾi loʊkˈeɪɾᵻd əkɹˌɑːs ðɪ ˈɑːɹnoʊ, ðə sˈiːst fɹʌm wˈʌn θˈaʊzənd θɹˈiːhˈʌndɹɪd fˈoːɹɾi θɹˈiː ðə kwˈɔːɹɾɚ ʌv sˈæntoʊ spɪɹˈiːɾoʊ wʌz fˈɪzɪkli ænd pəlˈɪɾɪkli ɐpˈɑːɹt fɹʌmðə ɹˈɛst ʌv flˈɔːɹəns.
As the only area of the city located across the Arno, the sieste (from 1343 the quarter) of Santo Spirito was physically and politically  apart from the rest of Florence.