wˈɛst ʌv hˈæməltən, ˌɛsˈɑːɹ sˈɛvənti fˈoːɹ kəntˈɪnjuːz wˈɛst tʊ ˈɛnd æt jˌuːˈɛs sˈɛvənti ˈeɪt ʌnsˈaɪnd ˌɛsˈɑːɹ fˈoːɹ, wˌaɪl jˌuːˈɛs tˈuːhˈʌndɹɪd sˈɛvənti ˈeɪt tˈɜːnz sˈaʊθ ɐlˈɔŋ jˌuːˈɛs fˈoːɹɾi θɹˈiː slˈæʃ ˌɛsˈɑːɹ sˈɛvəntˌiːn slˈæʃ ˌɛsˈɑːɹ wˈʌnhˈʌndɹɪd sˈɛvənti wˈʌn tə ɡˈɪn, wˌɛɹ ɪt tˈɜːnz wˈɛst ɐlˈɔŋ ˌɛsˈɑːɹ wˈʌnhˈʌndɹɪd ˈeɪtiːn tə ðə mˌɪsɪsˈɪpi stˈeɪt lˈaɪn.
West of Hamilton, SR 74 continues west to end at US 78 (unsigned SR 4), while US 278 turns south along US 43/SR 17/SR 171 to Guin, where it turns west along SR 118 to the Mississippi state line.