ɪn wˈʌn stˈʌdi, ðə tˌiːˌɑːɹkˈeɪ dʒˈiːn wʌz ɹᵻmˈuːvd fɹʌm ˌɛmbɹɪˈɑːnɪk mˈaɪs stˈɛm sˈɛlz wˌɪtʃ lˈɛd tə sᵻvˈɪɹ nˌʊɹɹəlˈɑːdʒɪkəl dɪzˈiːz, kˈɔːzɪŋ mˈoʊst mˈaɪs tə dˈaɪ wˈʌn mˈʌnθ ˈæftɚ bˈɜːθ.
In one study, the Trk gene was removed from embryonic mice stem cells which led to severe neurological disease, causing most mice to die one month after birth.