pˈoːɹt ɹˈoʊd stˈɑːɹts æt ðə nˈɔːɹθwˈɛstɚn kˈɔːɹnɚɹ ʌvðɪ ˈædəlˌeɪd sˈɪɾi sˈɛntɚ, æt ðɪ ˌɪntɚsˈɛkʃən ʌv nˈɔːɹθ tˈɛɹɪs ænd wˈɛst tˈɛɹɪs, ænd hˈɛdz nɔːɹθwˈɛst, tˈɜːnɪŋ nˈɔːɹθ æt ðəbˈɑːɹtən tə bɪkˌʌm pˈɑːɹt ʌvðə sˈɪɾi ɹˈɪŋ ɹˈaʊt, bᵻfˌoːɹ mˈiːɾɪŋ pˈɑːɹk tˈɛɹɪs æt hˈaɪndmɑːɹʃ ænd hˈɛdɪŋ nɔːɹθwˈɛst ɐɡˈɛn wɪð ɪts wˈaɪdənd mˈiːdiːən, kɹˈɔsɪŋ ðə nˈɔːɹθsˈaʊθ mˈoʊɾɚwˌeɪ ænd hˈɛdɪŋ θɹuː ðə sˈʌbɜːbz ʌv wˈʊdvɪl ænd tʃˈɛltənˌæm, bᵻfˌoːɹ ɪt tˈɜːnz nˈɔːɹθwɚdz æɾ ælbˈɜːtən tə kɹˈɔs ɡɹˈænd dʒˈʌŋkʃən ɹˈoʊd, tʃˈeɪndʒɪŋ nˈeɪm tə kəmˈɜːʃəl ɹˈoʊd ænd tˈɜːmᵻnˌeɪɾɪŋ nˌɑːt lˈɔŋ ˈæftɚwɚdz ɪnðə sˈɛntɚɹ ʌv pˈoːɹt ˈædəlˌeɪd.
Port Road starts at the north-western corner of the Adelaide city centre, at the intersection of North Terrace and West Terrace, and heads northwest, turning north at Thebarton to become part of the City Ring Route, before meeting Park Terrace at Hindmarsh and heading northwest again with its widened median, crossing the North-South Motorway and heading through the suburbs of Woodville and Cheltenham, before it turns northwards at Alberton to cross Grand Junction Road, changing name to Commercial Road and terminating not long afterwards in the centre of Port Adelaide.