mˈaɪɾəsˌoʊmz ɐpˈɪɹ tə hæv dᵻdʒˈɛnɚɹətˌɪvli ɪvˈɑːlvd fɹʌm mˌaɪɾəkˈɑːndɹiə mˌʌltɪpəl tˈaɪmz əkɹˌɑːs jˈuːkɐɹɪˌoʊt lˈɪnɪɪdʒᵻz, ænd ðɛɹ "məsˈeɪɪk" bˌaɪoʊkˈɛmɪstɹi ɪn ɛntɐmˈiːbə hˌɪstəlˈɪɾɪkə mˈeɪ ɹᵻflˈɛkt ɐ kəmpˈɑːzɪt ˈænsɛstɹi ɪnvˈɑːlvɪŋ bˈoʊθ jˈuːkɐɹɪˌoʊts ænd pɹˌoʊɾəbɐktˈɪɹiə.
Mitosomes appear to have degeneratively evolved from mitochondria multiple times across eukaryote lineages, and their "mosaic" biochemistry in Entamoeba histolytica may reflect a composite ancestry involving both eukaryotes and proteobacteria.