wˈuː ˈɛt ˈæl. hæv pˈɔɪntᵻd ˈaʊt ðæt ðɪs ɹᵻlˈeɪʃənʃˌɪp ɪz nˌɑːt tˈɪpɪkəl ʌvðɪ ˈɛndoʊkɹˌaɪn sˈɪstəm, ˈɪndᵻkˌeɪɾɪŋ ðæt tˈɑːɹ wˈʌn æktˈɪvᵻɾi mˈeɪ nˌɑːt biː kˈʌpəld tə dʒˈiːpɹˈoʊtiːnz ɪn sˌʌm tˈɪʃuːz, ɔːɹ ðæt tˈiː wˈʌn ˌeɪˈɛm mˈeɪ ˌɪntɚɹˈækt wɪð ˈʌðɚ ɹᵻsˈɛptɚ sˈʌbtaɪps.
Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.