ɪnðə pɹˈɑːsɛs ʌv bˈaɪndɪŋ, dᵻkˌæmɪθˈoʊniəm ˈæktᵻvˌeɪts diːpˈoʊlɑːɹɹˌaɪzᵻz ðə mˈoʊɾɚɹ ɛndplˈeɪt bˌʌt sˈɪns ðə dᵻkˌæmɪθˈoʊniəm ɪtsˈɛlf ɪz nˌɑːt dᵻɡɹˈeɪdᵻd, ðə mˈɛmbɹeɪn ɹᵻmˈeɪnz diːpˈoʊlɚɹˌaɪzd ænd ˌʌnɹᵻspˈɑːnsɪv tə nˈoːɹməl ˈæsɪtˌɪlkəlˌiːn ɹᵻlˈiːs.
In the process of binding, decamethonium activates (depolarizes) the motor endplate - but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.