wˌaɪl ɐsˈɪtɹɪtˌɪn ɪz lˈɛs lˌɪpəfˈɪlɪk ænd hɐz ɐ hˈæflˈaɪf ʌv ˈoʊnli fˈɪfti ˈaʊɚz, ɪɾ ɪz pˈɑːɹtli mətˈæbəlˌaɪzd tʊ ɪtɹˈɛtᵻnˌeɪt ɪnðə bˈɑːdi, sˌoʊ ðˌɐɾɪt ɪz stˈɪl ɐ lˈɔŋˈæktɪŋ tˈɛɹəɾədʒən ænd pɹˈɛɡnənsi ɪz pɹəhˈɪbɪɾᵻd fɔːɹ tˈuː jˈɪɹz ˈæftɚ θˈɛɹəpi.
While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.