ɪn ɐdˈɪʃən tə ðə ɹˈɛɡjʊlɚ kˈæst, ɐmˈɛɹɪkən kəmˈiːdiən ænd sˈæɾɚdˌeɪ nˈaɪt lˈaɪv ˈæktɹəs ˈeɪmi pˈoʊhlɚ ɡˈɛst stˈɑːɹd ɪnðɪ ˈɛpɪsˌoʊd æz ðə vˈɔɪs ʌv ɡɹˈændmɑː, ɐn ˈiːvəl ænd mənˈɪpjʊlətˌɪv ˈoʊld wˈʊmən hˌuː ɐdˈɑːptᵻd ɡˈæɹi ænd tɹˈaɪz tə fˈæʔn̩ hˌɪm ˌʌp tʊ ˈiːt hˌɪm ˈæftɚ ɡˈæɹi ɹˈʌnz ɐwˈeɪ.
In addition to the regular cast, American comedian and Saturday Night Live actress Amy Poehler guest starred in the episode as the voice of Grandma, an evil and manipulative old woman who adopted Gary and tries to fatten him up to eat him after Gary runs away.