ɪts pɹˈaɪmɚɹi kˈoːɹs ɪz ɐlˈɔŋ ðə sˈaʊθ slˈæʃ ˈiːst sˈaɪd ʌvðə dʒˌuːnɪˈɑːɾɚ ɹˈɪvɚ, wˌaɪl jˈuː.ˈɛs. ɹˈaʊt fˈaɪvhˈʌndɹɪd twˈɛnti tˈuː ɹˈʌnz ɐlˈɔŋ ðɪ ˈɑːpəzˌɪt sˈaɪd.
Its primary course is along the south/east side of the Juniata River, while U.S. Route 522 runs along the opposite side.