ɪn pɚtˈɪkjʊlɚ, nˈʊɹɹɑːnəl æktˈɪvᵻɾi hˈæzbiːn ʃˈoʊn tə lˈiːd tʊ ɐn ˈɪŋkɹiːs ɪn tˌiːˌɑːɹkˈeɪ bˈiː ˈɛm ˌɑːɹɹˌɛnˈeɪ tɹænskɹˈɪpʃən, æz wˈɛl æz tʃˈeɪndʒᵻz ɪn tˌiːˌɑːɹkˈeɪ bˈiː pɹˈoʊtiːn tɹˈæfɪkɪŋ, ɪŋklˈuːdɪŋ ɹᵻsˈɛptɚɹ ˌɛndoʊsɪtˈoʊsɪs ɔːɹ tɹænsloʊkˈeɪʃən.
In particular, neuronal activity has been shown to lead to an increase in TrkB mRNA transcription, as well as changes in TrkB protein trafficking, including receptor endocytosis or translocation.