tɹˈiːtmənt ʌv nˈaɪn wɪð tˈuːmˈɛθəlpˌɪpɚɹˌeɪziːn pɹˈoʊsiːdz baɪ ɹɪˈækʃən æt ðə lˈɛs hˈɪndɚd ʌvðə tˈuː ɐmˈiːnoʊ ɡɹˈuːps; sˌæpənˌɪfɪkˈeɪʃən ðˈɛn ɐfˈoːɹdz ɡɹˈɛpɐflˌɑːksɐsˌɪn tˈɛn.
Treatment of (9) with 2-methylpiperazine proceeds by reaction at the less hindered of the two amino groups; saponification then affords grepafloxacin (10).