sˈɪmɪlɚli, sˈɜːkjʊlˌeɪɾɪŋ ˈɛstɹeɪdɪˌɑːl lˈɛvəlz hɐvbɪn fˈaʊnd təbi ɹᵻdˈuːst baɪ fˈɪfti pɚsˈɛnt, wˌɪtʃ mˈeɪ ɹɪzˈʌlt ɪn ˈɛstɹədʒən dᵻfˈɪʃənsi ænd ɐsˈoʊsɪˌeɪɾᵻd sˈɪmptəmz.
Similarly, circulating estradiol levels have been found to be reduced by 50%, which may result in estrogen deficiency and associated symptoms.