ɐdˈɪʃənəli, tˌiːˌɑːɹkˈeɪ bˈiː hˈæzbiːn ʃˈoʊn tə ɹᵻdˈuːs ˈæmɪlˌɔɪdbˈeɪɾə pɹədˈʌkʃən baɪ ˌeɪpˌiːpˈiː bˈaɪndɪŋ ænd fˌɑːsfoːɹɪlˈeɪʃən, wˌaɪl tˌiːˌɑːɹkˈeɪ bˈiː klˈiːvɪdʒ baɪ dˈɛltəsˈɛkɹɪtˌeɪs blˈɑːks nˈoːɹməl tˌiːˌɑːɹkˈeɪ bˈiː æktˈɪvᵻɾi.
Additionally, TrkB has been shown to reduce amyloid-β production by APP binding and phosphorylation, while TrkB cleavage by δ-secretase blocks normal TrkB activity.