sˈɪmɪlɚ tə ðə pˌiːsˈiː vˈɜːʒən ʌvðə pɹˈiːviəs ɡˈeɪm, dʒˈɪmi nˈuːtɹɑːn vˌiːˈɛs. dʒˈɪmi nˈɛɡɐtɹˌɑːn ɪz ɐ θˈɜːdpˈɜːsən θɹˈiː dˈiː vˈɪdɪoʊ ɡˈeɪm wˌɪtʃ hɐz ɡˈeɪmpleɪ lˈɑːɹdʒli kənsˈɪstɪŋ ʌv pˈʌzəlz ænd pɹˈɑːbləmsˈɑːlvɪŋ, wɪð dʒˈɪmi hˌævɪŋ tə sˈɑːlv vˈɛɹiəs pˈʌzəlz tə pɹəɡɹˈɛs, sˈʌtʃ ɐz ɡˈæðɚɹɪŋ ɹᵻkwˈaɪɚd ˈaɪɾəmz ɔːɹ pˈæsɪŋ ˈɑːbstəkəlz.
Similar to the PC version of the previous game, Jimmy Neutron vs. Jimmy Negatron is a third-person 3D video game which has gameplay largely consisting of puzzles and problem-solving, with Jimmy having to solve various puzzles to progress, such as gathering required items or passing obstacles.