sˈɛkənd, ðɪ ˌɑːɹpˌiːˈiː ɪz ˈeɪbəl tə kəmjˈuːnᵻkˌeɪt wɪððɪ ɪmjˈuːn sˈɪstəm ɪn ˈɔːɹdɚ tə sˈaɪləns ɪmjˈuːn ɹɪˈækʃən ɪnðə hˈɛlθi ˈaɪ ɔːɹ, ɔnðɪ ˈʌðɚ hˈænd, tʊ ˈæktᵻvˌeɪt ðɪ ɪmjˈuːn sˈɪstəm ɪnðə kˈeɪs ʌv dɪzˈiːz.
Second, the RPE is able to communicate with the immune system in order to silence immune reaction in the healthy eye or, on the other hand, to activate the immune system in the case of disease.