ɪn tˈaɪp wˈʌn dˌaɪəbˈiːɾiːz mˈɛlɪɾəs, ðɛɹ ɪz dᵻɹˈɛkt dˈæmɪdʒ tə ðɪ ˈɛndoʊkɹˌaɪn pˈæŋkɹiəs ðæt ɹɪzˈʌlts ɪn ɪnsəfˈɪʃənt ˈɪnsəlˌɪn sˈɪnθəsˌɪs ænd sᵻkɹˈiːʃən.
In type 1 diabetes mellitus, there is direct damage to the endocrine pancreas that results in insufficient insulin synthesis and secretion.