mˈæɹid tə mˈɛɹi lˈuːkɹɛʃə kɹˈeɪtən ɪn ðɛɹ nˈeɪɾɪv dˈeɪtən, oʊhˈaɪoʊ, ˈɛdwɚd ɹᵻlˈaɪd ˌɔn mˈɛɹi tə kˈæɹi ˈaʊt hɪz ɹᵻkwˈɛst tə kɹiːˈeɪt ɐ kˈɑːlɪdʒ, wˌɪtʃ ᵻvˈɛntʃuːəli bɪkˌeɪm kɹˈeɪtən jˌuːnɪvˈɜːsᵻɾi.
Married to Mary Lucretia Creighton in their native Dayton, Ohio, Edward relied on Mary to carry out his request to create a college, which eventually became Creighton University.