bˈaɪndɪŋ ɐsˈeɪz wɪð ˌɛnˈɛs wˈʌn pɹˈoʊtiːn mjˈuːtənts ɪstˈæblɪʃt ðætðɪ ˌɑːɹɹˌɛnˈeɪbˈaɪndɪŋ dəmˈeɪn ʌvðɪ ˌɛnˈɛs wˈʌn pɹˈoʊtiːn ɪz ɹᵻkwˈaɪɚd fɔːɹ bˈaɪndɪŋ tə dˌiːˈɛs ˌɑːɹɹˌɛnˈeɪ æz wˈɛl æz fɔːɹ bˈaɪndɪŋ tə pˈɑːli ɐ ænd jˈuː sˈɪks ˌɛsˈɛn ˌɑːɹɹˌɛnˈeɪ.
Binding assays with NS1 protein mutants established that the RNA-binding domain of the NS1 protein is required for binding to dsRNA as well as for binding to polyA and U6 snRNA.