ᵻvˈɛntʃuːəli, sɪnˈæptɪk ɹɪˌoːɹɡɐnᵻzˈeɪʃən ænd plæstˈɪsᵻɾi ʌv ˌɛspˌiːˈɛn dɪvˈɛləps ˌɪntʊ ɐn ˈoʊvɚli sˈɛnsᵻtˌɪv stˈeɪt, wˌɪtʃ ɹɪzˈʌlts ɪn ɐbnˈoːɹməl ɹˈiːflɛks ˌæktɪvˈeɪʃən ʌv ˌɛspˌiːˈɛn dˈuː tʊ ˈæfɚɹənt stˈɪmjʊlˌaɪ, sˈʌtʃ ɐz bˈaʊəl ɔːɹ blˈædɚ dɪstˈɛnʃən.
Eventually, synaptic reorganization and plasticity of SPN develops into an overly sensitive state, which results in abnormal reflex activation of SPN due to afferent stimuli, such as bowel or bladder distension.