bˈʌfɐlˌɑːpɑːks ɪz kˈɔːzd baɪ bˈʌfɐlˌɑːpɑːks vˈaɪɹəs bˌiːpˌiːˌɛksvˈiː; ɪɾ ɪz ɐ pˈɑːksvɪɹˌɪdiː fɔːɹ wˌɪtʃ ðə nˈætʃɚɹəl hˈoʊst ɪz bˈʌfəlˌoʊ.
Buffalopox is caused by buffalopox virus (BPXV); it is a Poxviridae for which the natural host is buffalo.