ˈænɚ ɹᵻdʒˈiːnə stˈændz ɔnðɪ ɐtlˈæntɪk kˈoʊst, nɔːɹθwˈɛst ʌvðə mˈaʊθ ʌvðɪ ˌɛsɪkwˈiːboʊ ɹˈɪvɚ, nˈaɪntiːn kˌeɪˈɛm nˈɔːɹθ ʌv ɐdvˈɛntʃɚ, ænd wʌz ɪstˈæblɪʃt æz ɐ tˈaʊn ɪn nˈaɪntiːnhˈʌndɹɪd sˈɛvənti.
Anna Regina stands on the Atlantic coast, northwest of the mouth of the Essequibo River, 19 km north of Adventure, and was established as a town in 1970.