ˈɛm tˌiːˌoʊˈɑːɹ sˈɪɡnəlɪŋ ɪz hˌaɪpɚɹˈæktɪv ɪn spoːɹˈædɪk sˈækɹəl kɔːɹdˈoʊməz: ɪn wˈʌn stˈʌdi tˈɛn ˌaʊɾəv tˈɛn sˈækɹəl kɔːɹdˈoʊməz ɛɡzˈɪbɪɾᵻd fˌɑːsfoːɹɪlˈeɪʃən ʌv ɹˈɪbəsˌɑːməl pɹˈoʊtiːn ˈɛs sˈɪks ænd ˌiːˌaɪˈɛf fˈoːɹ ˌiːbˌiːpˈiː wˈʌn baɪ ɪmjˈuːnoʊhˌɪstəkˌɛmɪstɹi
mTOR signaling is hyperactive in sporadic sacral chordomas: in one study 10 out of 10 sacral chordomas exhibited phosphorylation of Ribosomal protein s6 and EIF4EBP1 by immunohistochemistry