ðə hˈaɪweɪ ɹˈʌnz ɐpɹˈɑːksɪmətli bᵻtwˌiːn ˌɪntɚstˈeɪt fˈoːɹɾi fˈaɪv ænd ˌɛsˈeɪtʃ wˈʌnhˈʌndɹɪd fˈoːɹɾi sˈɪks slˈæʃ fjˈuːtʃɚɹ ˌɛsˈeɪtʃ nˈaɪnti nˈaɪn ɪn ɡˈælvᵻstən kˈaʊnti, kənˈɛktɪŋ ðə sˈɪɾiz ʌv lˈiːɡ sˈɪɾi ænd kˈɛmə.
The highway runs approximately  between Interstate 45 and SH 146/future SH 99 in Galveston County, connecting the cities of League City and Kemah.