lˈɑːpɪnˌævɪɹ hˈæzbiːn ʃˈoʊn tʊ ɪmpˈɛɹ pɹˈoʊtiːn sˈɪnθəsˌɪs vˈaɪəɹ ˌeɪˌɛmpˈiːˈæktᵻvˌeɪɾᵻd pɹˈoʊtiːn kˈɪneɪs ˈæmpk ænd ˈiː ˌiːˈɛf tˈuː kˈɪneɪs ˈiː ˌiːˈɛf tˈuː kˈeɪ ˌæktɪvˈeɪʃən, ɐ mˈɛkənˌɪzəm ðæt ɪz sˈɪmɪlɚ tə ðɪ ˌæntɪvˈaɪɚɹəl ɪfˈɛkt ʌv pɹˈoʊtiːn fˈɑːsfɐtˌeɪs wˈʌn ɪnhˈɪbɪɾɚz.
Lopinavir has been shown to impair protein synthesis via AMP-activated protein kinase (AMPK) and eEF2 kinase (eEF2K) activation, a mechanism that is similar to the antiviral effect of protein phosphatase 1 inhibitors.