ˌɔn mˈɑːɹtʃ wˈʌn, nˈaɪntiːnhˈʌndɹɪd twˈɛnti wˈʌn, ɹˈaʊt sˈɪkstiːn wʌz tɹˈʌŋkeɪɾᵻd tʊ ˈɛnd ɪn lə ɹˈɔɪ wˌaɪl ðə pˈoːɹʃən ʌv ɪts fˈɔːɹmɚ ɹˈaʊɾɪŋ nˈɔːɹθ ʌv kˌælɪdˈoʊniə bɪkˌeɪm pˈɑːɹt əvɚ ɹˌiːɐlˈaɪnd ænd ɛkstˈɛndᵻd ɹˈaʊt fˈɪftiːn.
On March 1, 1921, Route 16 was truncated to end in Le Roy while the portion of its former routing north of Caledonia became part of a realigned and extended Route 15.