kɑːmˈɪsə ɪz loʊkˈeɪɾᵻd sˈaʊθiːst ʌv ɡˈɛlmə, ðə kˈoʊstəl sˈɪɾi nˈoʊn æz kælˈɑːmə baɪ ˈeɪntʃənt ɹˈoʊmən sˈɛtlɚz, ænd nɔːɹθwˈɛst ʌv sˈaʊk ˈɑːɹəz, nˈoʊn æz θˈæɡæst baɪ ˈeɪntʃənt bˈɜːbɚz ænd ɹˈoʊmənz.
Khamissa is located  southeast of Guelma, the coastal city known as Calama by ancient Roman settlers, and  northwest of Souk Ahras, known as Thagaste by ancient Berbers and Romans.