ɪnðɪ ˈæbsəns ʌv ˌɛnˈɛs wˈʌn, ðɪs pˈæθweɪ ɪz ɪnhˈɪbɪɾᵻd dˈʊɹɹɪŋ ˈæntaɪvˈaɪɚɹəl ɹᵻspˈɑːns tə hˈɔlt ˈɔːl pɹˈoʊtiːn tɹænslˈeɪʃən ðˈʌs stˈɑːpɪŋ ðə sˈɪnθəsˌɪs ʌv vˈaɪɚɹəl pɹˈoʊtiːnz; haʊˈɛvɚ, ðɪ ˌɪnfluːˈɛnzə vˈaɪɹəs ˌɛnˈɛs wˈʌn pɹˈoʊtiːn ɪz ɐn ˈeɪdʒənt ðæt sˈɜːkəmvˌɛnts hˈoʊst dᵻfˈɛnsᵻz tʊ ɐlˈaʊz vˈaɪɚɹəl dʒˈiːn tɹænskɹˈɪpʃən tʊ əkˈɜː.
In the absence of NS1, this pathway is inhibited during anti-viral response to halt all protein translation – thus stopping the synthesis of viral proteins; however, the influenza virus' NS1 protein is an agent that circumvents host defenses to allows viral gene transcription to occur.