ˈɪsə ˈɪbən ˈɑːli ˈæl kˈɑːlɪfə wʌz bˈɔːɹn ˌɔn twˈɛnti sˈɛvən noʊvˈɛmbɚ wˈʌn θˈaʊzənd ˈeɪthˈʌndɹɪd fˈoːɹɾi ˈeɪt, ɪn ɹˈɪfə fˈɔːɹt, bɑːɹˈeɪn, ðə fˈoːɹθbˈɔːɹn sˈʌn ʌv ʃˈeɪk ˈɑːli bˈɪn kˈɑːlɪfə ˈæl kˈɑːlɪfə wɪð tˈædʒbə bˈɪnt ˈɑːmæd ˈæl kˈɑːlɪfə, dˈɔːɾɚɹ ʌv ʃˈeɪk ˈɑːmæd bˈɪn sɐlmˈɑːn ˈæl kˈɑːlɪfə.
Isa ibn Ali Al Khalifa was born on 27 November 1848, in Riffa Fort, Bahrain, the fourth-born son of Sheikh Ali bin Khalifa Al Khalifa with Tajba bint Ahmad Al Khalifa, daughter of Shaikh Ahmad bin Salman Al Khalifa.