æz mˈɑːdᵻfˌaɪd sˈɛlf ˈæntɪdʒˌɛnz, ðeɪ ɑːɹ pətˈɛnʃəli ɪmjˌuːnoʊdʒˈɛnɪk wɛn kəmpˈɛɹd tʊ ʌnmˈɑːdᵻfˌaɪd sˈɛlf pɹˈoʊtiːnz æz ðɪ ɪmjˈuːn sˈɛlz tˈiːsˈɛlz wˌɪtʃ ɹˈɛkəɡnˌaɪz ðˌɛm ɑːɹ pˈɑːsᵻbli nˌɑːt sˈʌbdʒɛkt tə sˈɛntɹəl tˈɑːlɚɹəns mˈɛkənˌɪzəmz.
As modified self antigens, they are potentially immunogenic when compared to unmodified self proteins as the immune cells (T-cells) which recognise them are possibly not subject to central tolerance mechanisms.