ɪf ɐ pɚtˈɪkjʊlɚ ɹˈoʊɾeɪmɚɹ ʌv sˈaɪdtʃeɪn kænˈɑːt pˈɑːsᵻbli ɡˈɪv ɐ bˈɛɾɚɹ ˈɛnɚdʒi ðɐn ɐnˈʌðɚ ɹˈoʊɾeɪmɚɹ ʌvðə sˈeɪm sˈaɪdtʃeɪn, ðˈɛn ɹˈoʊɾeɪmɚɹ ɐ kæn biː ᵻlˈɪmᵻnˌeɪɾᵻd fɹʌm fˈɜːðɚ kənsˌɪdɚɹˈeɪʃən, wˌɪtʃ ɹᵻdˈuːsᵻz ðə sˈɜːtʃ spˈeɪs.
If a particular rotamer  of sidechain  cannot possibly give a better energy than another rotamer  of the same sidechain, then rotamer A can be eliminated from further consideration, which reduces the search space.