ɪnðɪ ˈæftɚmˌæθ ʌv bˈoʊθ ðə dʒˈɛnɑːʃən dʒˈɛnəsˌaɪd ænd kəsˈændɹə nˈoʊvəz ɹˌɛvɪlˈeɪʃən ʌv tʃˈɑːɹlz zˈeɪviɚz mjˈuːtənt pˈaʊɚz, æz wˈɛl æz hɪz skˈuːlz fˈʌŋkʃən æz ɐ mjˈuːtənt hˈeɪvən, ðɪ ˈɛksmˈɛn mˈʌst tɹˈaɪ tə bɹˈoʊkɚ pˈiːs ɐmˈɪdst ɹˈaɪzɪŋ hjˈuːmən slˈæʃ mjˈuːtənt tˈɛnʃənz, wˌaɪl stˈɪl kˈɑːmbæɾɪŋ ðə mjˈuːtənt θɹˈɛts ɚɹˈaɪzɪŋ wˈɜːldwaɪd.
In the aftermath of both the Genoshan genocide and Cassandra Nova's revelation of Charles Xavier's mutant powers, as well as his school's function as a mutant haven, the X-Men must try to broker peace amidst rising human/mutant tensions, while still combating the mutant threats arising worldwide.