ðiːz stˈʌdiz hæv hæd ɐ bɹˈɔːd ˈɪmpækt ɔnðə dɪvˈɛləpmənt, ɪvˌæljuːˈeɪʃən ænd ɹˈɛɡjʊlətˌoːɹi ɐpɹˈuːvəl ʌv dɹˈʌɡz, ænd hˈɛlpt tʊ ɪstˈæblɪʃ ðɪ ɪmpˈoːɹtəns ʌv dɹˈʌɡ ɹᵻsˈɪstəns ɐsˈeɪz ɪnðə dˈeɪɾədˈeɪ mˈænɪdʒmənt ʌv ɪnfˈɛktᵻd pˈeɪʃənts.
These studies have had a broad impact on the development, evaluation and regulatory approval of drugs, and helped to establish the importance of drug resistance assays in the day-to-day management of infected patients.