sˈɑːɹɡɹɐmˌoʊstɪm ɪz ɐ vˈɜːʒən ʌv dʒˌiːˈɛmsˌiːˌɛsˈɛf, wˌɪtʃ hɐz ɐ nˈoːɹməl ɹˈoʊl ɪn hjˈuːmən baɪˈɑːlədʒi, kˈɔːzɪŋ pɹoʊdʒˈɛnɪɾɚ sˈɛlz tə dˌɪfɚɹˈɛnʃɪˌeɪt ˌɪntʊ nˈuːtɹəfˌɪlz, mˈɑːnoʊsˌaɪts, mˈækɹəfɪdʒᵻz, ænd, mˈaɪɪlˌɔɪddᵻɹˈaɪvd dɛndɹˈɪɾɪk sˈɛlz; ɪt kæn ˈɔːlsoʊ ˈæktᵻvˌeɪt mətʃˈʊɹ ɡɹænˈuːləsˌaɪts ænd mˈækɹəfɪdʒᵻz, ænd kæn kəntɹˈɪbjuːt tə ðə dˌɪfɚɹˌɛnʃɪˈeɪʃən ʌv mˌɛɡəkˌæɹɪəsˈɪɾɪk pɹoʊdʒˈɛnɪɾɚz ænd ˈɜːɹɪθɹˌɔɪd pɹoʊdʒˈɛnɪɾɚ sˈɛlz.
Sargramostim is a version of GM-CSF, which has a normal role in human biology, causing progenitor cells to differentiate into neutrophils, monocytes, macrophages, and, myeloid-derived dendritic cells; it can also activate mature granulocytes and macrophages, and can contribute to the differentiation of megakaryocytic progenitors and erythroid progenitor cells.