ðə hˈaɪweɪ bɪɡˈɪnz æɾə dʒˈʌŋkʃən wɪð jˌuːˈɛs θɹˈiːhˈʌndɹɪd nˈaɪnti fˈaɪv ɪnðə fˈʊthɪlz ʌvðə siːˈɛɹə nᵻvˈædə, æt ðə dʒˈʌŋkʃən wɪð nᵻvˈædə hˈaɪweɪ tˈuːhˈʌndɹɪd ˈeɪt, æt ðə hˈæmlɪt ʌv hˈɑːlbɹʊk dʒˈʌŋkʃən.
The highway begins at a junction with US 395 in the foothills of the Sierra Nevada, at the junction with Nevada highway 208, at the hamlet of Holbrook Junction.