jˈuː.ˈɛs. ɹˈaʊt tˈuːhˈʌndɹɪd sˈɛvənti ˈeɪt jˌuːˈɛs tˈuːhˈʌndɹɪd sˈɛvənti ˈeɪt, mˈoʊstli ɪntˈɜːnəli dˈɛzɪɡnˌeɪɾᵻd baɪ ðɪ ˌæləbˈæmə dᵻpˈɑːɹtmənt ʌv tɹænspoːɹtˈeɪʃən æz stˈeɪt ɹˈaʊt sˈɛvənti fˈoːɹ ˌɛsˈɑːɹ sˈɛvənti fˈoːɹ, ɪz ɐ mˈeɪdʒɚɹ ˈiːst wˈɛst jˈuː.ˈɛs. hˈaɪweɪ əkɹˌɑːs ðə nˈɔːɹðɚn pˈɑːɹt ʌvðə jˈuː.ˈɛs. stˈeɪt ʌv ˌæləbˈæmə.
U.S. Route 278 (US 278), mostly internally designated by the Alabama Department of Transportation as State Route 74 (SR 74), is a major east–west U.S. highway across the northern part of the U.S. state of Alabama.