haʊˈɛvɚ, ɹˈoʊboʊ θɹˈiː ɹˈɪɡ wˈʌn ɪz ˈʌpɹɪɡjˌʊleɪɾᵻd dˈʊɹɹɪŋ ɡɹˈoʊθ ʌv kəmˈɪʃɚɹəl ˈæksɑːnz dˈʊɹɹɪŋ maɪɡɹˈeɪʃən təwˈɔːɹd ðə flˈoːɹ plˈeɪt, wˌɪtʃ siːkwˈɛstɚz ɹˈoʊboʊ wˈʌn slˈæʃ tˈuː ɪnsˈaɪd ðə sˈɛl wɪðˌɪn vˈɛsɪkəlz.
However, Robo-3 (Rig-1) is upregulated during growth of commissural axons during migration toward the floor plate, which sequesters Robo-1/2 inside the cell within vesicles.