hˌɪstɪdaɪnˈiːmiə əkˈɜːz æz ðə ɹɪzˈʌlt əvən ˈɪnbɔːɹn ˈɛɹɚɹ ʌv mətˈæbəlˌɪzəm ðæt mˈeɪ ɹɪzˈʌlt ɪn ˈiːðɚɹ ɐn ɪnˈæktɪv ɔːɹ ɐ sᵻvˈɪɹli ɹᵻdˈuːst hˈɪstɪdˌiːn æmˈoʊniəlˈaɪeɪs ˌeɪtʃˌeɪˈɛl ˈɛnzaɪm æktˈɪvᵻɾi.
Histidinemia occurs as the result of an inborn error of metabolism that may result in either an inactive or a severely reduced histidine ammonia-lyase (HAL) enzyme activity.