ɪɾ ɪz fˈæstɚ bˌʌt lˈɛs ˈækjʊɹət ðɐn dˈɛdˈɛnd ᵻlˌɪmᵻnˈeɪʃən ænd ɪz dʒˈɛnɚɹəli jˈuːzd ɪn sˌɪtʃuːˈeɪʃənz wˌɛɹ ðə pɹˈoʊtiːn ʌv ˈɪntɹɛst ɪz tˈuː lˈɑːɹdʒ fɚðə pɹˈɑːbləm təbi tɹˈæktəbəl baɪ dˌiːˌiːˈiː.
It is faster but less accurate than dead-end elimination and is generally used in situations where the protein of interest is too large for the problem to be tractable by DEE.