hɪz mətˈɜːnəl ɡɹˈændfɑːðɚ, ænd nˈeɪmseɪk, wʌz ɹˈælf ˈaɪsəks, dʒˌeɪˈɑːɹ., ɐ jˈeɪl ˈɛdʒuːkˌeɪɾᵻd mˈɜːtʃənt hˌuː wʌz pɹˈɑːmɪnənt ɪn nˈuː hˈeɪvən ænd bɹˈænfɚd, ænd hɪz pətˈɜːnəl ɡɹˈændfɑːðɚ wʌz ɹˈɛv. dʒˈɑːnəθən ɪndʒˈɜːsɑːl, tʃˈæplɪn fɚðə kənˈɛɾɪkət tɹˈuːps dˈʊɹɹɪŋ ðə fɹˈɛntʃ ænd ˈɪndiən wˈɔːɹ hˌuː wʌzðə bɹˈʌðɚɹ ʌv dʒˈæɹəd ɪndʒˈɜːsɑːl ˌɛsˈɑːɹ., ɐ bɹˈɪɾɪʃ kəlˈoʊnɪəl əfˈɪʃəl.
His maternal grandfather, and namesake, was Ralph Isaacs, Jr., a Yale educated merchant who was prominent in New Haven and Branford, and his paternal grandfather was Rev. Jonathan Ingersoll, chaplain for the Connecticut Troops during the French and Indian War who was the brother of Jared Ingersoll Sr., a British colonial official.