ðɪs ɪz səpˈoːɹɾᵻd ɛkspˌɛɹɪmˈɛntəli ɪn tʃˈɪk, ɪnwˌɪtʃ flˈoːɹ plˈeɪt ɪndˈʌkʃən, æz wˈɛl æz ɐsˈoʊsiətˌɪv vˈɛntɹəl nˈɜːvəs tˈɪʃuː dˌɪfɚɹˌɛnʃɪˈeɪʃən, ɪz mˈiːdɪˌeɪɾᵻd baɪ ðə sᵻkɹˈiːɾᵻd sˈɪɡnəlɪŋ mˈɑːlɪkjˌuːl sˈɑːnɪk hˈɛdʒhɑːɡ ˌɛsˌeɪtʃˈeɪtʃ.
This is supported experimentally in chick, in which floor plate induction, as well as associative ventral nervous tissue differentiation, is mediated by the secreted signaling molecule sonic hedgehog (Shh).