ðə pɹˌɛpɚɹˈeɪʃən ʌv kwˈɪnəlˌoʊnz bˈɛɹɪŋ ɐ sˈʌbstɪtʃˌuːənt æt pəzˈɪʃən fˈaɪv ɪz kˈɑːmplᵻkˌeɪɾᵻd baɪ ðə ɡɹˈeɪɾɚɹ ɪlˌɛktɹoʊfˈɪlɪk kˈæɹɪktɚɹ ʌvðɪ ˈeɪt pəzˈɪʃən.
The preparation of quinolones bearing a substituent at position 5 is complicated by the greater electrophilic character of the 8 position.